RGD Reference Report - Is sorbitol dehydrogenase gene expression affected by streptozotocin-diabetes in the rat? - Rat Genome Database

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Is sorbitol dehydrogenase gene expression affected by streptozotocin-diabetes in the rat?

Authors: Kicic, E  Palmer, TN 
Citation: Kicic E and Palmer TN, Biochim Biophys Acta. 1994 May 25;1226(2):213-8.
RGD ID: 8548781
Pubmed: PMID:8204669   (View Abstract at PubMed)

The polyol pathway, which comprises the enzymes aldose reductase and sorbitol dehydrogenase, is recognised to play a major role in the pathogenesis of diabetic complications. Although there has been extensive research on aldose reductase, the role of sorbitol dehydrogenase has been overlooked. This study examined the response of sorbitol dehydrogenase gene expression to streptozotocin-diabetes (STZ-diabetes) in the rat and whether these changes were reversed by insulin. STZ-diabetes increased testicular sorbitol dehydrogenase gene expression in a manner that was not reversible by insulin but had no effect on gene expression in kidney and brain. A secondary question was the relationship between sorbitol dehydrogenase and aldose reductase gene expression in STZ-diabetes. STZ-diabetes increased renal aldose reductase gene expression in a manner that was not reversible by insulin but had no effect on gene expression in the brain, testes and muscle. Thus, STZ-diabetes causes changes in sorbitol dehydrogenase gene expression which do not parallel those in aldose reductase, implying that expression of the two genes is not regulated via a common mechanism. Furthermore, changes in sorbitol dehydrogenase and aldose reductase gene expression cannot be fully explained on the basis of the osmoregulatory hypothesis, suggesting that regulation is mediated via mechanisms that are multifactorial and tissue-specific.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISOAkr1b1 (Rattus norvegicus)8548781; 8548781mRNA:increased expression:kidney (rat)RGD 
Experimental Diabetes Mellitus  IEP 8548781mRNA:increased expression:kidney (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Akr1b1  (aldo-keto reductase family 1 member B1)

Genes (Mus musculus)
Akr1b1  (aldo-keto reductase family 1 member B)

Genes (Homo sapiens)
AKR1B1  (aldo-keto reductase family 1 member B)


Additional Information