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Aldose reductase-deficient mice develop nephrogenic diabetes insipidus.

Authors: Ho, HT  Chung, SK  Law, JW  Ko, BC  Tam, SC  Brooks, HL  Knepper, MA  Chung, SS 
Citation: Ho HT, etal., Mol Cell Biol. 2000 Aug;20(16):5840-6.
Pubmed: (View Article at PubMed) PMID:10913167

Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy. However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found that they had no apparent developmental or reproductive abnormality except that they drank and urinated significantly more than their wild-type littermates. These ALR2-deficient mice exhibited a partially defective urine-concentrating ability, having a phenotype resembling that of nephrogenic diabetes insipidus.

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RGD Object Information
RGD ID: 8548674
Created: 2014-03-18
Species: All species
Last Modified: 2014-03-18
Status: ACTIVE



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