Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: AKR1B1 (aldo-keto reductase family 1 member B) Homo sapiens
Analyze
Symbol: AKR1B1
Name: aldo-keto reductase family 1 member B
Description: Exhibits alditol:NADP+ 1-oxidoreductase activity; glyceraldehyde oxidoreductase activity; and retinal dehydrogenase activity. Involved in several processes, including cellular hyperosmotic salinity response; glycoside metabolic process; and retinoid metabolic process. Localizes to cytosol and nucleoplasm. Implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Biomarker of hepatocellular carcinoma and stomach cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADR; aldehyde reductase 1; aldehyde reductase 1 (low km aldose reductase) (5.8 kb psti fragment, probably the functional gene); aldo-keto reductase family 1 member B1; aldo-keto reductase family 1, member B1 (aldose reductase); aldose reductase; ALDR1; ALR2; AR; Lii5-2 CTCL tumor antigen; low Km aldose reductase; MGC1804
Orthologs:
Mus musculus (house mouse) : Akr1b3 (aldo-keto reductase family 1, member B3 (aldose reductase))  MGI  Alliance
Rattus norvegicus (Norway rat) : Akr1b1 (aldo-keto reductase family 1 member B)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : AKR1B1 (aldo-keto reductase family 1 member B)
Canis lupus familiaris (dog) : AKR1B1 (aldo-keto reductase family 1 member B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akr1b1 (aldo-keto reductase family 1 member B)
Sus scrofa (pig) : AKR1B1 (aldo-keto reductase family 1 member B)
Chlorocebus sabaeus (African green monkey) : AKR1B1 (aldo-keto reductase family 1 member B)
more info ...
Related Pseudogenes: AKR1B1P1   AKR1B1P2   AKR1B1P3   AKR1B1P4   AKR1B1P5   AKR1B1P6   AKR1B1P7   AKR1B1P8  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl7134,442,356 - 134,459,284 (-)EnsemblGRCh38hg38GRCh38
GRCh387134,442,350 - 134,459,239 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377134,127,107 - 134,143,888 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367133,777,647 - 133,794,428 (-)NCBINCBI36hg18NCBI36
Build 347133,584,361 - 133,601,143NCBI
Celera7128,864,507 - 128,881,287 (-)NCBI
Cytogenetic Map7q33NCBI
HuRef7128,428,754 - 128,445,534 (-)NCBIHuRef
CHM1_17134,061,391 - 134,078,169 (-)NCBICHM1_1
CRA_TCAGchr7v27133,471,421 - 133,488,201 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on AKR1B1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732178
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.