Glom19 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Glom19 (Glomerulus QTL 19) Rattus norvegicus

Symbol: Glom19
Name: Glomerulus QTL 19
RGD ID: 2312567
Previously known as: glomeruli with microaneurysms day 3; MA day 3
Trait: kidney glomerulus morphology trait   (VT:0005325)    
Measurement Type: index of glomerular damage   (CMO:0001135)    
LOD Score: 1.9
P Value: 0.006
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2445,456,990 - 146,803,430RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0449,906,054 - 145,611,886RGD_MAPPER_PIPELINERnor6.0
Rnor_5.04116,181,405 - 208,908,285RGDRnor5.0
RGSC_v3.4443,686,352 - 149,560,340RGDRGSC3.4
Cross Type: backcross
Strains Crossed: LEW/Maas LEW/Mol 




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glom19Ratfocal segmental glomerulosclerosis  IAGP 2312422 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glom19Ratcortical renal glomerulopathies  IDA 2312422 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glom19Ratindex of glomerular damage  IDA 2312422 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glom19Ratantibody  IDA 2312422 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glom19Ratex vivo light microscopy with digital image analysis  IDA 2312422 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glom19RatLEW/Maas  IEA 2312422 RGD 
Glom19RatLEW/Mol  IEA 2312422 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Glom19Ratkidney glomerulus morphology trait  IDA 2312422 RGD 


#
Reference Title
Reference Citation
1. Genetic predisposition for glomerulonephritis-induced glomerulosclerosis in rats is linked to chromosome 1. Ijpelaar DH, etal., Physiol Genomics. 2008 Oct 8;35(2):173-81. Epub 2008 Aug 5.


1 to 20 of 1282 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
7512277LOC102550644uncharacterized LOC10255064444546330045616095Rat
620348Cav2caveolin 244561676645624144Rat
2280Cav1caveolin 144564062445673708Rat
9112364LOC103692063uncharacterized LOC10369206344568273545711751Rat
7671121LOC102550745uncharacterized LOC10255074544571182445736550Rat
3082MetMET proto-oncogene, receptor tyrosine kinase44579045645898139Rat
1549770Capza2capping actin protein of muscle Z-line subunit alpha 244597814246014032Rat
1303148St7suppression of tumorigenicity 744604165546289745Rat
41017039LOC12010244460S ribosomal protein L23a-like44614691746153007Rat
621346Wnt2Wnt family member 244632840846374673Rat
621579Asz1ankyrin repeat, SAM and basic leucine zipper domain containing 144640048546456085Rat
2332CftrCF transmembrane conductance regulator44656126946728759Rat
41373703LOC120102563U6 spliceosomal RNA44675272146752827Rat
628691Cttnbp2cortactin binding protein 244680097546964681Rat
41325296LOC120102241uncharacterized LOC12010224144690628746931844Rat
1566227U2surp-ps1U2 snRNP-associated SURP domain containing, pseudogene 144700588447008963Rat
1308442Lsm8LSM8 homolog, U6 small nuclear RNA associated44730625947312125Rat
1564660Ankrd7ankyrin repeat domain 744731227047336754Rat
1597712Pdia6l1protein disulfide isomerase family A, member 6 like 144760658247607800Rat
11453204LOC108350673uncharacterized LOC10835067344874646548832870Rat

1 to 20 of 1282 rows
1 to 20 of 1613 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10144D4Mgh1623946293326962933508Ratregion
10145D4Arb1039446293321762933611Ratregion
10156D4Mit181934131730729131730924Ratregion
10157D4Wox171574131730755131730914Ratregion
10158D4Arb162514131730738131730991Ratregion
10513D4Arb63064118050728118051034Ratregion
10525D4Mit311244108086268108086390Ratregion
10560D4Mit121794103194805103194984Ratregion
10561D4Wox201444103194798103194942Ratregion
10562D4Arb212804103194656103194936Ratregion
10782D4Mit81044102684777102684881Ratregion
11009D4Wox2113547888281778882954Ratregion
11010D4Hri112647888281778882945Ratregion
11011D4Mgh420747887850478878711Ratregion
11012D4Wox2214847888598978886137Ratregion
11013D4Arb729047888586778886157Ratregion
11014D4Mit729947888589078886189Ratregion
11015D4Mit2412847888281578882945Ratregion
11171D4Hri215547036205170362206Ratregion
11172D4Wox2418547036204170362226Ratregion
1 to 20 of 1613 rows

Flank 1: (D4Rat153)
Rat AssemblyChrPosition (strand)Source
RGSC_v3.1442,637,314 - 42,637,464RGD
RH 2.0 Map4341.4RGD
SHRSP x BN Map427.2RGD
Peak: (D4Rat41)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2496,130,123 - 96,130,297 (+)MAPPER
Rnor_6.0497,758,884 - 97,759,057NCBI
Rnor_5.04162,544,759 - 162,544,932UniSTS
RGSC_v3.4496,623,259 - 96,623,433RGD
RGSC_v3.4496,623,260 - 96,623,433UniSTS
RGSC_v3.1496,867,740 - 96,867,914RGD
Celera490,826,995 - 90,827,168UniSTS
SHRSP x BN Map448.75RGD
SHRSP x BN Map448.75UniSTS
Cytogenetic Map4q31UniSTS
Flank 2: (D4Rat60)
Rat AssemblyChrPosition (strand)Source
mRatBN7.24146,803,311 - 146,803,430 (+)MAPPER
Rnor_6.04145,611,768 - 145,611,886NCBI
Rnor_5.04208,908,167 - 208,908,285UniSTS
RGSC_v3.44149,560,221 - 149,560,340RGD
RGSC_v3.44149,560,222 - 149,560,340UniSTS
RGSC_v3.14149,805,063 - 149,805,181RGD
Celera4135,357,633 - 135,357,751UniSTS
RH 3.4 Map4942.7UniSTS
RH 3.4 Map4942.7RGD
SHRSP x BN Map471.41UniSTS
SHRSP x BN Map471.41RGD
FHH x ACI Map487.92RGD
Cytogenetic Map4q42UniSTS


1 to 10 of 145 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat

1 to 10 of 145 rows


Note Type Note Reference
qtl_cross_type backcross  
qtl_general software used: phenotypic distribution by Kolmogorov-Smirnov test; QTL mapping by MapMaker 2312422
qtl_general measurement method: animals were injected with (2mg/kg body wt) anti-Thy1.1 ER4 antibody; on day 3 percentage of glomeruli with microaneurysms was determined in 20 glomerular cross-sections per rat 2312422
qtl_general inducing agent: anti-Thy-1 glomerulonephritis (antiThy1.1 ER4G) 2312422
qtl_general number of animals used: 145 females 2312422