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Gene: Dguok (deoxyguanosine kinase) Rattus norvegicus
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Symbol: Dguok
Name: deoxyguanosine kinase
RGD ID: 1304799
Description: Predicted to have deoxyguanosine kinase activity. Involved in ATP biosynthetic process; mitochondrial ATP synthesis coupled electron transport; and negative regulation of neuron projection development. Predicted to localize to cytosol and mitochondrion. Used to study mitochondrial DNA depletion syndrome 3. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 3; and mitochondrial metabolism disease. Orthologous to human DGUOK (deoxyguanosine kinase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: deoxyguanosine kinase, mitochondrial; LOC297389; MGC188845
Orthologs:
Homo sapiens (human) : DGUOK (deoxyguanosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Dguok (deoxyguanosine kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dguok (deoxyguanosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : DGUOK (deoxyguanosine kinase)
Canis lupus familiaris (dog) : DGUOK (deoxyguanosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dguok (deoxyguanosine kinase)
Sus scrofa (pig) : DGUOK (deoxyguanosine kinase)
Chlorocebus sabaeus (African green monkey) : DGUOK (deoxyguanosine kinase)
Heterocephalus glaber (naked mole-rat) : Dguok (deoxyguanosine kinase)
more info ...
Allele / Splice: Dguokem4Mcwi   Dguokem3Mcwi   Dguokem1Mcwi   Dguokem2Mcwi  
Genetic Models: SS-Dguokem2Mcwi SS-Dguokem1Mcwi SS-Dguokem3Mcwi SS-Dguokem4Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04115,180,433 - 115,208,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4115,180,433 - 115,208,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04179,770,727 - 179,798,683 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,697,251 - 117,725,383 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14117,942,451 - 117,969,809 (-)NCBI
Celera4104,980,935 - 105,008,470 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Dguok
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1304799
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.