Dguok (deoxyguanosine kinase) - Rat Genome Database

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Gene: Dguok (deoxyguanosine kinase) Rattus norvegicus
Analyze
Symbol: Dguok
Name: deoxyguanosine kinase
RGD ID: 1304799
Description: Predicted to enable deoxyguanosine kinase activity. Involved in mitochondrial ATP synthesis coupled electron transport and negative regulation of neuron projection development. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Used to study mitochondrial DNA depletion syndrome 3. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 3; and mitochondrial metabolism disease. Orthologous to human DGUOK (deoxyguanosine kinase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deoxyguanosine kinase, mitochondrial; LOC297389; MGC188845
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Dguokem4Mcwi   Dguokem3Mcwi   Dguokem1Mcwi   Dguokem2Mcwi  
Genetic Models: SS-Dguokem4Mcwi SS-Dguokem3Mcwi SS-Dguokem2Mcwi SS-Dguokem1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,544,784 - 117,572,414 (-)NCBIGRCr8
mRatBN7.24115,987,101 - 116,014,733 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,979,094 - 116,014,733 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,465,198 - 121,493,156 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04117,240,371 - 117,268,329 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,854,010 - 115,881,956 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04115,180,433 - 115,208,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4115,180,433 - 115,208,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04179,770,727 - 179,798,683 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,697,251 - 117,725,383 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,942,451 - 117,969,809 (-)NCBI
Celera4104,980,935 - 105,008,470 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (ISO)
mitochondrion  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for mtDNA Depletion Syndrome. Jing R, etal., Cell Rep. 2018 Nov 6;25(6):1469-1484.e5. doi: 10.1016/j.celrep.2018.10.036.
4. Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen. Loh SH, etal., Cell Death Differ. 2008 Feb;15(2):283-98. Epub 2007 Nov 16.
5. The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA. Mandel H, etal., Nat Genet. 2001 Nov;29(3):337-41.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Severe mtDNA depletion and dependency on catabolic lipid metabolism in DGUOK knockout mice. Zhou X, etal., Hum Mol Genet. 2019 Sep 1;28(17):2874-2884. doi: 10.1093/hmg/ddz103.
Additional References at PubMed
PMID:1664183   PMID:7918681   PMID:8706825   PMID:10455141   PMID:11427893   PMID:12477932   PMID:14651853   PMID:18614015   PMID:21630459   PMID:26773591   PMID:33368311  


Genomics

Comparative Map Data
Dguok
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,544,784 - 117,572,414 (-)NCBIGRCr8
mRatBN7.24115,987,101 - 116,014,733 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,979,094 - 116,014,733 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,465,198 - 121,493,156 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04117,240,371 - 117,268,329 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,854,010 - 115,881,956 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04115,180,433 - 115,208,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4115,180,433 - 115,208,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04179,770,727 - 179,798,683 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,697,251 - 117,725,383 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,942,451 - 117,969,809 (-)NCBI
Celera4104,980,935 - 105,008,470 (-)NCBICelera
Cytogenetic Map4q34NCBI
DGUOK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38273,926,880 - 73,958,946 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl273,926,826 - 73,958,961 (+)EnsemblGRCh38hg38GRCh38
GRCh37274,154,007 - 74,186,073 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,007,461 - 74,039,596 (+)NCBINCBI36Build 36hg18NCBI36
Build 34274,065,607 - 74,097,743NCBI
Celera273,985,216 - 74,017,351 (+)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef273,889,617 - 73,921,742 (+)NCBIHuRef
CHM1_1274,083,278 - 74,115,396 (+)NCBICHM1_1
T2T-CHM13v2.0273,935,347 - 73,967,403 (+)NCBIT2T-CHM13v2.0
Dguok
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,457,199 - 83,483,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,457,199 - 83,483,951 (-)EnsemblGRCm39 Ensembl
GRCm38683,480,214 - 83,506,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,480,217 - 83,506,969 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,430,208 - 83,456,963 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,445,875 - 83,472,552 (-)NCBIMGSCv36mm8
Celera685,461,324 - 85,488,129 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Dguok
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,738,859 - 11,773,902 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,739,904 - 11,773,884 (-)NCBIChiLan1.0ChiLan1.0
DGUOK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21252,424,898 - 52,456,909 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A52,427,652 - 52,459,666 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,000,969 - 74,032,993 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A75,510,768 - 75,542,563 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A75,510,768 - 75,542,563 (+)Ensemblpanpan1.1panPan2
DGUOK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11749,107,085 - 49,139,366 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1749,104,546 - 49,168,782 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,747,777 - 48,780,029 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,966,601 - 49,998,895 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,966,603 - 49,999,099 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,982,805 - 49,015,059 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01749,049,971 - 49,082,509 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,608,020 - 49,640,318 (-)NCBIUU_Cfam_GSD_1.0
Dguok
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629210,474,072 - 10,511,248 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556226,627 - 264,905 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936556226,643 - 263,517 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DGUOK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl369,054,761 - 69,091,341 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1369,054,749 - 69,091,366 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2372,209,549 - 72,245,858 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DGUOK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11433,320,957 - 33,356,088 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1433,320,969 - 33,356,093 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604578,811,375 - 78,845,097 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dguok
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474929,516,229 - 29,561,220 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474929,494,866 - 29,560,887 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dguok
182 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:18
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000066678
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat

Markers in Region
RH134697  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24115,987,780 - 115,988,799 (+)MAPPERmRatBN7.2
Rnor_6.04115,181,109 - 115,182,127NCBIRnor6.0
Rnor_5.04179,771,403 - 179,772,421UniSTSRnor5.0
RGSC_v3.44117,697,927 - 117,698,945UniSTSRGSC3.4
Celera4104,981,611 - 104,982,629UniSTS
Cytogenetic Map4q34UniSTS
RH141839  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24116,009,885 - 116,010,093 (+)MAPPERmRatBN7.2
Rnor_6.04115,203,214 - 115,203,421NCBIRnor6.0
Rnor_5.04179,793,836 - 179,794,043UniSTSRnor5.0
RGSC_v3.44117,720,536 - 117,720,743UniSTSRGSC3.4
Celera4105,003,623 - 105,003,830UniSTS
RH 3.4 Map4667.7UniSTS
Cytogenetic Map4q34UniSTS


Genetic Models
This gene Dguok is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 34 11 8
Low 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC168743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000066678   ⟹   ENSRNOP00000062535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,987,105 - 116,014,733 (-)Ensembl
Rnor_6.0 Ensembl4115,180,433 - 115,208,061 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084388   ⟹   ENSRNOP00000072937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,987,637 - 116,014,730 (-)Ensembl
Rnor_6.0 Ensembl4115,180,971 - 115,208,026 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113435   ⟹   ENSRNOP00000082324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,979,094 - 116,014,733 (-)Ensembl
RefSeq Acc Id: NM_001106602   ⟹   NP_001100072
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,544,786 - 117,572,414 (-)NCBI
mRatBN7.24115,987,105 - 116,014,733 (-)NCBI
Rnor_6.04115,180,433 - 115,208,061 (-)NCBI
Rnor_5.04179,770,727 - 179,798,683 (-)NCBI
RGSC_v3.44117,697,251 - 117,725,383 (-)RGD
Celera4104,980,935 - 105,008,470 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236735   ⟹   XP_006236797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,545,313 - 117,572,359 (-)NCBI
mRatBN7.24115,987,632 - 116,014,709 (-)NCBI
Rnor_6.04115,180,960 - 115,208,028 (-)NCBI
Rnor_5.04179,770,727 - 179,798,683 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006236736   ⟹   XP_006236798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,545,932 - 117,572,359 (-)NCBI
mRatBN7.24115,988,249 - 116,014,709 (-)NCBI
Rnor_6.04115,181,626 - 115,208,028 (-)NCBI
Rnor_5.04179,770,727 - 179,798,683 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006236737   ⟹   XP_006236799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,545,313 - 117,572,359 (-)NCBI
mRatBN7.24115,987,632 - 116,014,709 (-)NCBI
Rnor_6.04115,180,960 - 115,208,055 (-)NCBI
Rnor_5.04179,770,727 - 179,798,683 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763056   ⟹   XP_008761278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,545,313 - 117,572,359 (-)NCBI
mRatBN7.24115,987,632 - 116,014,709 (-)NCBI
Rnor_6.04115,180,960 - 115,208,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763057   ⟹   XP_008761279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,545,313 - 117,572,359 (-)NCBI
mRatBN7.24115,987,632 - 116,014,709 (-)NCBI
Rnor_6.04115,180,960 - 115,208,055 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107337   ⟹   XP_038963265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,544,784 - 117,572,359 (-)NCBI
mRatBN7.24115,987,101 - 116,014,709 (-)NCBI
RefSeq Acc Id: XM_039107338   ⟹   XP_038963266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,554,119 - 117,572,359 (-)NCBI
mRatBN7.24115,996,339 - 116,014,709 (-)NCBI
RefSeq Acc Id: XM_039107340   ⟹   XP_038963268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,545,313 - 117,572,351 (-)NCBI
mRatBN7.24115,987,632 - 116,014,718 (-)NCBI
RefSeq Acc Id: XM_039107341   ⟹   XP_038963269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,554,119 - 117,572,359 (-)NCBI
mRatBN7.24115,996,339 - 116,014,709 (-)NCBI
RefSeq Acc Id: XM_063285800   ⟹   XP_063141870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,545,313 - 117,572,359 (-)NCBI
RefSeq Acc Id: XM_063285801   ⟹   XP_063141871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,545,313 - 117,555,783 (-)NCBI
RefSeq Acc Id: XM_063285802   ⟹   XP_063141872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,545,313 - 117,572,351 (-)NCBI
RefSeq Acc Id: XM_063285803   ⟹   XP_063141873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,545,313 - 117,555,771 (-)NCBI
RefSeq Acc Id: XM_063285804   ⟹   XP_063141874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,545,313 - 117,572,351 (-)NCBI
RefSeq Acc Id: NP_001100072   ⟸   NM_001106602
- UniProtKB: D3ZDE4 (UniProtKB/TrEMBL),   A6IAM4 (UniProtKB/TrEMBL),   A6IAM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236799   ⟸   XM_006236737
- Peptide Label: isoform X6
- UniProtKB: A6IAM5 (UniProtKB/TrEMBL),   A6IAM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236797   ⟸   XM_006236735
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K478 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236798   ⟸   XM_006236736
- Peptide Label: isoform X5
- UniProtKB: A6IAM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761278   ⟸   XM_008763056
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008761279   ⟸   XM_008763057
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZV32 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072937   ⟸   ENSRNOT00000084388
RefSeq Acc Id: ENSRNOP00000062535   ⟸   ENSRNOT00000066678
RefSeq Acc Id: XP_038963265   ⟸   XM_039107337
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038963268   ⟸   XM_039107340
- Peptide Label: isoform X14
- UniProtKB: B5DEP0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963269   ⟸   XM_039107341
- Peptide Label: isoform X12
- UniProtKB: A6IAM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963266   ⟸   XM_039107338
- Peptide Label: isoform X8
RefSeq Acc Id: ENSRNOP00000082324   ⟸   ENSRNOT00000113435
RefSeq Acc Id: XP_063141870   ⟸   XM_063285800
- Peptide Label: isoform X7
- UniProtKB: A6IAM6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141872   ⟸   XM_063285802
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063141874   ⟸   XM_063285804
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063141871   ⟸   XM_063285801
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063141873   ⟸   XM_063285803
- Peptide Label: isoform X11
Protein Domains
Deoxynucleoside kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDE4-F1-model_v2 AlphaFold D3ZDE4 1-278 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693187
Promoter ID:EPDNEW_R3704
Type:multiple initiation site
Name:Dguok_1
Description:deoxyguanosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04115,208,019 - 115,208,079EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304799 AgrOrtholog
BioCyc Gene G2FUF-44006 BioCyc
BioCyc Pathway PWY-7224 [purine deoxyribonucleosides salvage] BioCyc
BioCyc Pathway Image PWY-7224 BioCyc
Ensembl Genes ENSRNOG00000011617 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066678 ENTREZGENE
  ENSRNOT00000066678.3 UniProtKB/TrEMBL
  ENSRNOT00000084388.2 UniProtKB/TrEMBL
  ENSRNOT00000113435.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro Deoxynucleoside_kinase UniProtKB/TrEMBL
  DNK_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:297389 UniProtKB/TrEMBL
NCBI Gene 297389 ENTREZGENE
PANTHER DEOXYGUANOSINE KINASE, MITOCHONDRIAL UniProtKB/TrEMBL
  DEOXYNUCLEOSIDE KINASE UniProtKB/TrEMBL
Pfam dNK UniProtKB/TrEMBL
PhenoGen Dguok PhenoGen
PIRSF DNK UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011617 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2K478 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZV32 ENTREZGENE, UniProtKB/TrEMBL
  A6IAM4 ENTREZGENE, UniProtKB/TrEMBL
  A6IAM5 ENTREZGENE, UniProtKB/TrEMBL
  A6IAM6 ENTREZGENE, UniProtKB/TrEMBL
  A6IAM7_RAT UniProtKB/TrEMBL
  A6IAM9 ENTREZGENE, UniProtKB/TrEMBL
  B5DEP0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZDE4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Dguok  deoxyguanosine kinase   Dguok_predicted  deoxyguanosine kinase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dguok_predicted  deoxyguanosine kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED