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QTL Registration

General

QTL: Pia28 (Pristane induced arthritis QTL 28) Rattus norvegicus

Symbol:

Pia28

Name:

Pristane induced arthritis QTL 28

RGD ID:

2302051

Previously known as:

Rf2

Trait:

blood autoantibody amount (VT:0003725)

Measurement Type:

serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)

LOD Score:

5.3

P Value:

0.001

Variance:

Not Available

Inheritance Type:

additive

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	73,630,210 - 118,630,210	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	4	75,258,970 - 120,258,970	RGD_MAPPER_PIPELINE	Rnor_6.0
Rnor_5.0	4	140,044,845 - 185,044,845	RGD_MAPPER_PIPELINE	Rnor_5.0
RGSC_v3.4	4	74,123,346 - 119,123,346	RGD_MAPPER_PIPELINE	RGSC_v3.4

Cross Type:

intercross

Strains Crossed:

DA/ZtmRhd E3/ZtmRhd

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

rheumatoid arthritis (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

increased susceptibility to induced arthritis (IDA)

joint swelling (IDA)

Experimental Data Annotations Click to see Annotation Detail View

Clinical Measurement

serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (IDA)

Experimental Condition

pristane (IDA)

Measurement Method

enzyme linked immunosorbent assay (IDA)

Vertebrate Trait

blood autoantibody amount (IDA)

Rat Strain

DA/ZtmRhd (IEA)

E3/ZtmRhd (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	The genetic control of rheumatoid factor production in a rat model of rheumatoid arthritis.	Wernhoff P, etal., Arthritis Rheum. 2003 Dec;48(12):3584-96.

Region

Markers in Region

The following Markers overlap with this region.

RGD ID

Symbol

Expected Size

Chr

Start

Stop

Species

Match

Position Markers

Peak: (D4Rat41)

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	96,130,123 - 96,130,297 (+)	MAPPER
Rnor_6.0	4	97,758,884 - 97,759,057	NCBI
Rnor_5.0	4	162,544,759 - 162,544,932	UniSTS
RGSC_v3.4	4	96,623,259 - 96,623,433	RGD
RGSC_v3.4	4	96,623,260 - 96,623,433	UniSTS
Celera	4	90,826,995 - 90,827,168	UniSTS
RGSC_v3.1	4	96,867,740 - 96,867,914	RGD
SHRSP x BN Map	4	48.75	RGD
SHRSP x BN Map	4	48.75	UniSTS
Cytogenetic Map	4	q31	UniSTS

Additional Information

RGD Curation Notes

Note Type	Note	Reference
qtl_cross_type	intercross
qtl_general	inducing agent and dosage: pristane 150 microliter software used: Map Manager QTX software and R/qtl in R-Plus package	2302026
qtl_general	significant association observed between IgG-RF and total IgG levels	2302026
qtl_general	gender: males	2302026
qtl_general	measurement method: serum samples were collected on days 6, 14, 35, 49, 100, and desired levels were quantified by ELISA	2302026

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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QTL: Pia28 (Pristane induced arthritis QTL 28) Rattus norvegicus

Mammalian Phenotype