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Gene: Cav3 (caveolin 3) Rattus norvegicus
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Symbol: Cav3
Name: caveolin 3
Description: Exhibits several functions, including ion channel binding activity; nitric-oxide synthase binding activity; and potassium channel inhibitor activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; positive regulation of cellular component organization; and ventricular cardiac muscle cell action potential. Localizes to several cellular components, including T-tubule; cell surface; and neuromuscular junction. Colocalizes with several cellular components, including Z disc; intercalated disc; and sarcolemma. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); isolated elevated serum creatine phosphokinase levels; and muscle tissue disease (multiple). Orthologous to human CAV3 (caveolin 3); PARTICIPATES IN platelet-derived growth factor signaling pathway; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: caveolin-3; MGC105449
Orthologs:
Homo sapiens (human) : CAV3 (caveolin 3)  HGNC  Alliance
Mus musculus (house mouse) : Cav3 (caveolin 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cav3 (caveolin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CAV3 (caveolin 3)
Canis lupus familiaris (dog) : CAV3 (caveolin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cav3 (caveolin 3)
Sus scrofa (pig) : CAV3 (caveolin 3)
Chlorocebus sabaeus (African green monkey) : CAV3 (caveolin 3)
Heterocephalus glaber (naked mole-rat) : Cav3 (caveolin 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04144,382,945 - 144,398,919 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4144,382,945 - 144,398,917 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04207,683,202 - 207,699,176 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44148,294,428 - 148,310,380 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14148,539,268 - 148,555,221 (+)NCBI
Celera4134,152,488 - 134,168,462 (+)NCBICelera
Cytogenetic Map4q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cav3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2281
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.