Cav3 (caveolin 3) - Rat Genome Database

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Gene: Cav3 (caveolin 3) Ictidomys tridecemlineatus
Analyze
Symbol: Cav3
Name: caveolin 3
RGD ID: 12731227
Description: ENCODES a protein that exhibits enzyme binding (ortholog); molecular adaptor activity (ortholog); nitric-oxide synthase binding (ortholog); INVOLVED IN actin filament organization (ortholog); calcium ion transport (ortholog); cardiac muscle cell development (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); Cardiomegaly (ortholog); cardiomyopathy (ortholog); FOUND IN caveola (ortholog); cell surface (ortholog); intercalated disc (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: caveolin-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494214,631,527 - 14,644,827 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366024,264,889 - 4,278,161 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366024,264,896 - 4,278,160 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IEA,ISO)
calcium ion transport  (IEA,ISO)
cardiac muscle cell development  (IEA,ISO)
cardiac muscle hypertrophy  (IEA,ISO)
caveola assembly  (IEA,ISO)
cell differentiation  (IEA,ISO)
cellular response to organonitrogen compound  (ISO)
cholesterol homeostasis  (IEA,ISO)
cytoplasmic microtubule organization  (IEA,ISO)
detection of muscle stretch  (IEA)
endocytosis  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
glucose homeostasis  (IEA,ISO)
heart trabecula formation  (IEA,ISO)
MAPK cascade  (IEA,ISO)
membrane raft organization  (IEA,ISO)
myoblast fusion  (IEA,ISO)
myotube differentiation  (IEA,ISO)
negative regulation of calcium ion transport  (IEA,ISO)
negative regulation of cardiac muscle hypertrophy  (IEA,ISO)
negative regulation of cell growth involved in cardiac muscle cell development  (ISO)
negative regulation of cell size  (IEA)
negative regulation of MAPK cascade  (IEA,ISO)
negative regulation of membrane depolarization during cardiac muscle cell action potential  (IEA)
negative regulation of potassium ion transmembrane transport  (ISO)
negative regulation of sarcomere organization  (IEA)
nucleus localization  (IEA,ISO)
plasma membrane organization  (IEA,ISO)
plasma membrane repair  (IEA,ISO)
positive regulation of caveolin-mediated endocytosis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of microtubule polymerization  (ISO)
positive regulation of myotube differentiation  (IEA,ISO)
protein localization  (IEA,ISO)
protein localization to plasma membrane  (IEA,ISO)
regulation of branching involved in mammary gland duct morphogenesis  (IEA,ISO)
regulation of calcium ion import  (IEA)
regulation of calcium ion transport  (IEA,ISO)
regulation of cardiac muscle cell action potential involved in regulation of contraction  (IEA)
regulation of cardiac muscle contraction  (IEA)
regulation of cytosolic calcium ion concentration  (IEA)
regulation of heart rate  (IEA)
regulation of membrane depolarization during cardiac muscle cell action potential  (IEA)
regulation of membrane potential  (IEA,ISO)
regulation of p38MAPK cascade  (IEA,ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
regulation of signal transduction by receptor internalization  (IEA,ISO)
regulation of skeletal muscle contraction  (IEA)
regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
regulation of ventricular cardiac muscle cell membrane depolarization  (IEA)
regulation of ventricular cardiac muscle cell membrane repolarization  (IEA)
response to hypoxia  (ISO)
response to ischemia  (ISO)
triglyceride metabolic process  (IEA,ISO)
ventricular cardiac muscle cell action potential  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cav3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494214,631,527 - 14,644,827 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366024,264,889 - 4,278,161 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366024,264,896 - 4,278,160 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAV3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3838,733,802 - 8,746,758 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl38,733,802 - 8,841,808 (+)EnsemblGRCh38hg38GRCh38
GRCh3738,775,488 - 8,788,444 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3638,750,496 - 8,763,451 (+)NCBINCBI36Build 36hg18NCBI36
Build 3438,750,495 - 8,763,450NCBI
Celera38,710,271 - 8,723,238 (+)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef38,709,553 - 8,722,499 (+)NCBIHuRef
CHM1_138,725,885 - 8,738,871 (+)NCBICHM1_1
T2T-CHM13v2.038,724,971 - 8,737,928 (+)NCBIT2T-CHM13v2.0
Cav3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396112,436,466 - 112,449,833 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6112,436,466 - 112,449,833 (+)EnsemblGRCm39 Ensembl
GRCm386112,459,505 - 112,472,872 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6112,459,505 - 112,472,872 (+)EnsemblGRCm38mm10GRCm38
MGSCv376112,409,499 - 112,422,866 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366112,425,278 - 112,438,649 (+)NCBIMGSCv36mm8
Celera6114,297,536 - 114,310,896 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.26NCBI
Cav3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84147,137,993 - 147,153,967 (+)NCBIGRCr8
mRatBN7.24145,582,168 - 145,598,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4145,582,060 - 145,598,137 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4150,974,343 - 150,990,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04146,755,146 - 146,771,143 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04145,376,415 - 145,392,431 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04144,382,945 - 144,398,919 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4144,382,945 - 144,398,917 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04207,683,202 - 207,699,176 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44148,294,428 - 148,310,380 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14148,539,268 - 148,555,221 (+)NCBI
Celera4134,152,488 - 134,168,462 (+)NCBICelera
Cytogenetic Map4q41NCBI
Cav3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955561325,944 - 335,914 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955561326,008 - 335,911 (+)NCBIChiLan1.0ChiLan1.0
CAV3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v228,744,068 - 8,760,421 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan138,748,826 - 8,765,179 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v038,684,829 - 8,697,731 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.138,928,069 - 8,940,942 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl38,928,069 - 8,940,942 (+)Ensemblpanpan1.1panPan2
CAV3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1209,384,901 - 9,398,055 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl209,384,901 - 9,401,196 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha209,418,382 - 9,431,544 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0209,414,987 - 9,428,087 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl209,414,987 - 9,428,087 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1209,136,869 - 9,150,024 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0209,481,732 - 9,494,836 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0209,455,880 - 9,468,982 (-)NCBIUU_Cfam_GSD_1.0
CAV3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1365,117,795 - 65,131,273 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11365,117,868 - 65,130,886 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21372,400,156 - 72,412,174 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CAV3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12244,726,597 - 44,740,456 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2244,727,624 - 44,740,459 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041121,826,639 - 121,839,504 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cav3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247313,347,984 - 3,364,581 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247313,348,172 - 3,363,772 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005333843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSSTOT00000013325   ⟹   ENSSTOP00000011943
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366024,264,889 - 4,278,161 (-)Ensembl
RefSeq Acc Id: XM_005333843   ⟹   XP_005333900
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494214,631,527 - 14,644,827 (+)NCBI
SpeTri2.0NW_0049366024,264,896 - 4,278,160 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005333900 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000011943.3
GenBank Protein KAG3295023 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005333900   ⟸   XM_005333843
- UniProtKB: I3MKS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000011943   ⟸   ENSSTOT00000013325


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000013328 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000013325.3 UniProtKB/TrEMBL
InterPro Caveolin UniProtKB/TrEMBL
  Caveolin_CS UniProtKB/TrEMBL
NCBI Gene Cav3 ENTREZGENE
PANTHER PTHR10844 UniProtKB/TrEMBL
  PTHR10844:SF16 UniProtKB/TrEMBL
Pfam Caveolin UniProtKB/TrEMBL
PROSITE CAVEOLIN UniProtKB/TrEMBL
UniProt I3MKS8 ENTREZGENE, UniProtKB/TrEMBL