Ctsb (cathepsin B) - Rat Genome Database

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Gene: Ctsb (cathepsin B) Rattus norvegicus
Symbol: Ctsb
Name: cathepsin B
RGD ID: 621509
Description: Enables several functions, including cysteine-type endopeptidase activity; kininogen binding activity; and protein self-association. Involved in several processes, including cellular response to mechanical stimulus; response to dexamethasone; and response to interleukin-4. Located in several cellular components, including apical plasma membrane; external side of plasma membrane; and sarcolemma. Colocalizes with caveola and perinuclear region of cytoplasm. Used to study hepatocellular carcinoma and high grade glioma. Biomarker of several diseases, including acute necrotizing pancreatitis; cerebrovascular disease (multiple); fascioliasis; fatty liver disease; and renal tubular acidosis. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B); PARTICIPATES IN chaperone mediated autophagy pathway; antigen processing and presentation pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cathepsin B1; RSG-2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21537,389,636 - 37,410,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,389,629 - 37,410,500 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1539,242,069 - 39,263,185 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01540,392,878 - 40,413,994 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01538,850,264 - 38,871,139 (+)NCBIRnor_WKY
Rnor_6.01546,316,741 - 46,337,613 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,316,741 - 46,337,612 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01550,081,535 - 50,102,407 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,402,829 - 42,423,701 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11542,418,600 - 42,439,400 (+)NCBI
Celera1537,073,910 - 37,094,782 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminobutyric acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (ISO)
4-aminopyridine  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aloxistatin  (ISO)
alpha,alpha-trehalose  (ISO)
alprazolam  (ISO)
aluminium sulfate (anhydrous)  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphibole asbestos  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
azetidine  (ISO)
azithromycin  (EXP)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
Beta-Solamarine  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
Brusatol  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium dichloride  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon disulfide  (ISO)
carbon nanotube  (ISO)
ceruletide  (EXP)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
cholesterol  (ISO)
choline  (EXP)
chondroitin sulfate  (ISO)
ciprofibrate  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
dactolisib  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
graphite  (ISO)
hydrogen peroxide  (EXP)
hydroxychloroquine  (ISO)
hypochlorous acid  (ISO)
imiquimod  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
kainic acid  (EXP)
L-methionine  (EXP,ISO)
leupeptin  (ISO)
Liensinine  (ISO)
lipopolysaccharide  (ISO)
lutein  (ISO)
LY294002  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metam  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methoxychlor  (EXP)
morphine  (EXP)
morusin  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
naringin  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
okadaic acid  (ISO)
omeprazole  (ISO)
ozone  (EXP)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
patulin  (ISO)
pepstatin A  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenacetin  (EXP)
phenobarbital  (ISO)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
Pyridostigmine bromide  (EXP)
pyrimethamine  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
quizartinib  (ISO)
raloxifene  (EXP)
retinyl acetate  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (EXP)
succimer  (ISO)
sulindac  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
Tiron  (ISO)
titanium dioxide  (ISO)
tobramycin  (EXP)
trans-caffeic acid  (EXP)
trichloroethene  (ISO)
triclosan  (ISO)
trifluridine  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Y-27632  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Immediate upregulation of proteins belonging to different branches of the apoptotic cascade in the retina after optic nerve transection and optic nerve crush. Agudo M, etal., Invest Ophthalmol Vis Sci. 2009 Jan;50(1):424-31. Epub 2008 Sep 4.
2. Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2008 Sep;39(9):2603-10. Epub 2008 Jul 17.
3. Significance of a common epitope of plant and animal endomembranes. Bolwell GP J Cell Sci 1986 Jun;82:187-201.
4. Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice. Cattaruzza F, etal., Gastroenterology. 2011 Nov;141(5):1864-74.e1-3. Epub 2011 Jul 28.
5. Multiple apoptogenic proteins are involved in the nuclear translocation of Apoptosis Inducing Factor during transient focal cerebral ischemia in rat. Chaitanya GV and Babu PP, Brain Res. 2008 Dec 30;1246:178-90. Epub 2008 Oct 9.
6. Spinal cathepsin S and fractalkine contribute to chronic pain in collagen induced arthritis. Clark AK, etal., Arthritis Rheum. 2011 Dec 27. doi: 10.1002/art.34351.
7. ATP-activated, high-molecular-mass proteinase-I from rat skeletal muscle is a cysteine proteinase-alpha 1-macroglobulin complex. Dahlmann B, etal., Biochim Biophys Acta. 1989 May 31;991(2):253-62.
8. Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells. Di Piazza M, etal., J Virol. 2007 Apr;81(8):4186-98. Epub 2007 Feb 7.
9. Interleukin-4 downregulates the cyclic tensile stress-induced matrix metalloproteinases-13 and cathepsin B expression by rat normal chondrocytes. Doi H, etal., Acta Med Okayama. 2008 Apr;62(2):119-26.
10. Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats. Donohue TM, etal., Alcohol Clin Exp Res. 2007 Nov;31(11):1944-52. Epub 2007 Sep 11.
11. The protective effect of dexanabinol (HU-211) on nitric oxide and cysteine protease-mediated neuronal death in focal cerebral ischemia. Durmaz R, etal., Neurochem Res. 2008 Sep;33(9):1683-91. Epub 2008 Apr 11.
12. Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat. Ellis RC, etal., Exp Neurol 2005 May;193(1):19-28.
13. Reduced expression and proteolytic susceptibility of lubricin/superficial zone protein may explain early elevation in the coefficient of friction in the joints of rats with antigen-induced arthritis. Elsaid KA, etal., Arthritis Rheum. 2007 Jan;56(1):108-16.
14. Increased muscle proteolysis after local trauma mainly reflects macrophage-associated lysosomal proteolysis. Farges MC, etal., Am J Physiol Endocrinol Metab 2002 Feb;282(2):E326-35.
15. Prognostic significance of cathepsins B and L in primary human breast cancer. Foekens JA, etal., J Clin Oncol. 1998 Mar;16(3):1013-21.
16. Immune-compromised state in the rat pancreas after chronic alcohol exposure: the role of peroxisome proliferator-activated receptor gamma. Fortunato F, etal., J Pathol. 2007 Dec;213(4):441-52.
17. Label-free quantitative analysis of one-dimensional PAGE LC/MS/MS proteome: application on angiotensin II-stimulated smooth muscle cells secretome. Gao BB, etal., Mol Cell Proteomics. 2008 Dec;7(12):2399-409. Epub 2008 Aug 2.
18. Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections. Gartland A, etal., Am J Pathol. 2009 Dec;175(6):2668-75. Epub 2009 Nov 5.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. Cathepsin B, a cysteine protease implicated in metastatic progression, is also expressed during regression of the rat prostate and mammary glands. Guenette RS, etal., Eur J Biochem 1994 Dec 1;226(2):311-21.
22. Enterokinase induces severe necrosis and rapid mortality in cerulein pancreatitis: characterization of a novel noninvasive rat model of necro-hemorrhagic pancreatitis. Hartwig W, etal., Surgery. 2007 Sep;142(3):327-36.
23. Expression of cathepsin P mRNA, protein and activity in the rat choriocarcinoma cell line, Rcho-1, during giant cell transformation. Hassanein M, etal., Placenta. 2007 Aug-Sep;28(8-9):912-9. Epub 2007 Jan 10.
24. Regulation and function of aquaporin-1 in glioma cells. Hayashi Y, etal., Neoplasia. 2007 Sep;9(9):777-87.
25. Hypertension-mediated albuminuria is associated with reduced lysosomal activity in the kidney and the heart. Hilliard LM, etal., Am J Nephrol. 2009;29(5):454-64. Epub 2008 Nov 21.
26. Endostatin expression in neurons during the early stage of cerebral ischemia is associated with neuronal apoptotic cell death in adult hypertensive rat model of stroke. Hou Q, etal., Brain Res. 2009 Nov 24.
27. Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse. Hsing LC, etal., J Autoimmun. 2009 Aug 5.
28. A novel amplicon at 8p22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma. Hughes SJ, etal., Proc Natl Acad Sci U S A 1998 Oct 13;95(21):12410-5.
29. Mechanisms of polyamine catabolism-induced acute pancreatitis. Hyvonen MT, etal., Biochem Soc Trans. 2007 Apr;35(Pt 2):326-30.
30. Cysteine proteinases in bronchoalveolar epithelial cells and lavage fluid of rat lung. Ishii Y, etal., J Histochem Cytochem. 1991 Apr;39(4):461-8.
31. Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH. Jane DT, etal., Biol Chem. 2006 Feb;387(2):223-34.
32. Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. Johnson EM, etal., J Virol. 2009 Oct;83(19):9630-40. Epub 2009 Jul 29.
33. Differential expression of cysteine and aspartic proteases during progression of atherosclerosis in apolipoprotein E-deficient mice. Jormsjo S, etal., Am J Pathol. 2002 Sep;161(3):939-45.
34. Changes in the activity of lysosomal enzymes in rat kidneys in the course of acute pancreatitis. Lakowska H, etal., Med Sci Monit. 2001 Nov-Dec;7(6):1193-7.
35. Cystatin B deficiency sensitizes neurons to oxidative stress in progressive myoclonus epilepsy, EPM1. Lehtinen MK, etal., J Neurosci. 2009 May 6;29(18):5910-5.
36. Cathepsin gene expression profile in rat acute pneumococcal otitis media. Li-Korotky HS, etal., Laryngoscope 2004 Jun;114(6):1032-6.
37. Trafficking of lysosomal cathepsin B-green fluorescent protein to the surface of thyroid epithelial cells involves the endosomal/lysosomal compartment. Linke M, etal., J Cell Sci 2002 Dec 15;115(Pt 24):4877-89.
38. Induced expression of cathepsins and cystatin C in a murine model of demyelination. Ma J, etal., Neurochem Res. 2007 Feb;32(2):311-20. Epub 2006 Nov 4.
39. Leupeptin inhibits ventilator-induced diaphragm dysfunction in rats. Maes K, etal., Am J Respir Crit Care Med. 2007 Jun 1;175(11):1134-8. Epub 2007 Mar 22.
40. TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes. Mahurkar S, etal., BMC Med Genet. 2008 Aug 16;9:80.
41. Autophagy in human type 2 diabetes pancreatic beta cells. Masini M, etal., Diabetologia. 2009 Jun;52(6):1083-6. Epub 2009 Apr 15.
42. Differential expression of multiple cathepsin mRNAs in the rat testis during maturation and following lonidamine induced tissue restructuring. Mathur PP, etal., Biochem Mol Biol Int. 1997 Jun;42(2):217-33.
43. Cysteine-proteinase-inhibiting function of T kininogen and of its proteolytic fragments. Moreau T, etal., Eur J Biochem. 1988 Apr 5;173(1):185-90.
44. Cathepsin B and H activities and cystatin C concentrations in cerebrospinal fluid from patients with leptomeningeal metastasis. Nagai A, etal., Clin Chim Acta. 2003 Mar;329(1-2):53-60.
45. Cystatin C and cathepsin B in CSF from patients with inflammatory neurologic diseases. Nagai A, etal., Neurology. 2000 Dec 26;55(12):1828-32.
46. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
47. Biochemical properties and intracellular processing of lysosomal cathepsins B and H. Nishimura Y, etal., Biol Pharm Bull. 1995 Jun;18(6):829-36.
48. New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors. Ohashi A, etal., Biochem Biophys Res Commun. 2003 Jun 20;306(1):98-103.
49. Cathepsin L plays an important role in the lysosomal degradation of L-lactate dehydrogenase. Ohshita T and Hiroi Y, Biosci Biotechnol Biochem. 2006 Sep;70(9):2254-61. Epub 2006 Sep 7.
50. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
51. Pretreatment with a combination of quercetin and alpha-tocopherol ameliorates adenosine triphosphatases and lysosomal enzymes in myocardial infarcted rats. Punithavathi VR and Prince PS, Life Sci. 2009 Dec 1.
52. Role of chaperone-mediated autophagy in degrading Huntington's disease-associated huntingtin protein. Qi L and Zhang XD, Acta Biochim Biophys Sin (Shanghai). 2014 Feb;46(2):83-91. doi: 10.1093/abbs/gmt133. Epub 2013 Dec 8.
53. Alterations in certain lysosomal glycohydrolases and cathepsins in rats on dexamethasone administration. Rajashree S and Puvanakrishnan R, Mol Cell Biochem. 1996 Jan 26;154(2):165-70.
54. GOA pipeline RGD automated data pipeline
55. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
56. Possible involvement of cathepsin B released by microglia in methylmercury-induced cerebellar pathological changes in the adult rat. Sakamoto M, etal., Neurosci Lett. 2008 Sep 19;442(3):292-6. Epub 2008 Jul 11.
57. Identification of cDNA clones encoding a precursor of rat liver cathepsin B. San Segundo B, etal., Proc Natl Acad Sci U S A 1985 Apr;82(8):2320-4.
58. Alterations of cathepsins B, H and L in proximal tubules from polycystic kidneys of the Han:SPRD rat. Schaefer L, etal., Kidney Int. 1996 Aug;50(2):424-31.
59. Effect of vitamin E and human placenta cysteine peptidase inhibitor on expression of cathepsins B and L in implanted hepatoma Morris 5123 tumor model in Wistar rats. Sebzda T, etal., World J Gastroenterol. 2005 Jan 28;11(4):587-92.
60. Renal tubular cell protein breakdown in uninephrectomized and ammonium chloride-loaded rats. Shechter P, etal., J Am Soc Nephrol. 1994 Nov;5(5):1201-7.
61. Oxidative Modifications of Rat Liver Cell Components During Fasciola hepatica Infection. Siemieniuk E, etal., Toxicol Mech Methods. 2008 Jul;18(6):519-524. Epub 2008 Jun 23.
62. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
63. Decreased glomerular proteinase activity in the streptozotocin diabetic rat. Song RH, etal., Am J Nephrol. 1999;19(3):441-6.
64. Expression of cathepsins B, H, and L and their inhibitors as markers of transitional cell carcinoma of the bladder. Staack A, etal., Urology. 2004 Jun;63(6):1089-94.
65. Identification and possible regulation of muscle cell lysosomal protease activity by exogenous protease inhibitors. Stauber WT, etal., Acta Biol Med Ger. 1981;40(10-11):1317-22.
66. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
67. Alzheimer's disease amyloid beta-clipping enzyme (APP secretase): identification, purification, and characterization of the enzyme. Tagawa K, etal., Biochem Biophys Res Commun 1991 May 31;177(1):377-87.
68. High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells. Vidotti DB, etal., Am J Physiol Renal Physiol. 2004 Jun;286(6):F1039-45. Epub 2004 Jan 13.
69. An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid. Wang Y, etal., Autophagy. 2008 Feb 16;4(2):214-26. Epub 2007 Dec 3.
70. Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Wen YD, etal., Autophagy. 2008 Aug 16;4(6):762-9. Epub 2008 Jun 6.
71. Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways. Wu X, etal., Hepatology. 2008 Jun;47(6):1905-15.
Additional References at PubMed
PMID:1639824   PMID:1837142   PMID:2350688   PMID:6203523   PMID:6574504   PMID:7890620   PMID:7890671   PMID:8612130   PMID:8740363   PMID:8811434   PMID:9034150   PMID:9310336  
PMID:12782676   PMID:14586591   PMID:14651853   PMID:14720218   PMID:15255544   PMID:15614436   PMID:15831716   PMID:17285857   PMID:18060871   PMID:18338260   PMID:18363826   PMID:18782536  
PMID:19199708   PMID:21217776   PMID:21374014   PMID:21415591   PMID:21492153   PMID:22270907   PMID:22952693   PMID:23211306   PMID:23337787   PMID:23376485   PMID:23533145   PMID:23748042  
PMID:23986436   PMID:24006456   PMID:24616078   PMID:25713304   PMID:28618037   PMID:28835281   PMID:29375046   PMID:30353345   PMID:31302164   PMID:31973644   PMID:33173960  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21537,389,636 - 37,410,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,389,629 - 37,410,500 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1539,242,069 - 39,263,185 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01540,392,878 - 40,413,994 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01538,850,264 - 38,871,139 (+)NCBIRnor_WKY
Rnor_6.01546,316,741 - 46,337,613 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,316,741 - 46,337,612 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01550,081,535 - 50,102,407 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,402,829 - 42,423,701 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11542,418,600 - 42,439,400 (+)NCBI
Celera1537,073,910 - 37,094,782 (+)NCBICelera
Cytogenetic Map15p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38811,842,524 - 11,868,087 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl811,842,524 - 11,869,533 (-)EnsemblGRCh38hg38GRCh38
GRCh37811,700,033 - 11,725,596 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36811,737,442 - 11,763,055 (-)NCBINCBI36Build 36hg18NCBI36
Build 34811,739,235 - 11,763,044NCBI
Celera810,829,316 - 10,854,967 (-)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef810,630,970 - 10,656,616 (-)NCBIHuRef
CHM1_1811,765,442 - 11,791,090 (-)NCBICHM1_1
T2T-CHM13v2.087,872,212 - 7,897,789 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391463,359,911 - 63,383,372 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1463,359,911 - 63,383,372 (+)EnsemblGRCm39 Ensembl
GRCm381463,122,462 - 63,145,923 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1463,122,462 - 63,145,923 (+)EnsemblGRCm38mm10GRCm38
MGSCv371463,741,302 - 63,764,758 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361462,076,575 - 62,100,031 (+)NCBIMGSCv36mm8
Celera1460,885,230 - 60,908,693 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.24NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540353,085,574 - 53,093,809 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540353,086,236 - 53,100,217 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
Mhudiblu_PPA_v087,333,498 - 7,359,264 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12526,048,237 - 26,056,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2526,048,253 - 26,055,801 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2526,693,298 - 26,713,566 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02526,191,391 - 26,211,634 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2526,190,645 - 26,292,033 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12526,136,951 - 26,157,236 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02526,041,126 - 26,061,383 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02526,192,122 - 26,212,434 (+)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1415,011,711 - 15,033,877 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11415,014,139 - 15,035,081 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21416,202,844 - 16,223,498 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.187,246,076 - 7,269,655 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl87,246,013 - 7,268,854 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605235,165,795 - 35,191,160 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475825,366,840 - 25,373,954 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475825,366,120 - 25,384,554 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ctsb
95 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:85
Interacting mature miRNAs:100
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,410,214 - 37,410,417 (+)MAPPERmRatBN7.2
Rnor_6.01546,337,320 - 46,337,522NCBIRnor6.0
Rnor_5.01550,102,114 - 50,102,316UniSTSRnor5.0
RGSC_v3.41542,423,408 - 42,423,610UniSTSRGSC3.4
Celera1537,094,489 - 37,094,691UniSTS
Cytogenetic Map15p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,410,327 - 37,410,507 (+)MAPPERmRatBN7.2
Rnor_6.01546,337,433 - 46,337,612NCBIRnor6.0
Rnor_5.01550,102,227 - 50,102,406UniSTSRnor5.0
RGSC_v3.41542,423,521 - 42,423,700UniSTSRGSC3.4
Celera1537,094,602 - 37,094,781UniSTS
Cytogenetic Map15p12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 5 1 1
Medium 3 43 57 41 19 41 8 11 74 30 40 10 8
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014177   ⟹   ENSRNOP00000014178
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1537,389,629 - 37,410,500 (+)Ensembl
Rnor_6.0 Ensembl1546,316,741 - 46,337,612 (+)Ensembl
RefSeq Acc Id: NM_022597   ⟹   NP_072119
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21537,389,636 - 37,410,508 (+)NCBI
Rnor_6.01546,316,741 - 46,337,613 (+)NCBI
Rnor_5.01550,081,535 - 50,102,407 (+)NCBI
RGSC_v3.41542,402,829 - 42,423,701 (+)RGD
Celera1537,073,910 - 37,094,782 (+)RGD
Protein Sequences
Protein RefSeqs NP_072119 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40993 (Get FASTA)   NCBI Sequence Viewer  
  AAH72490 (Get FASTA)   NCBI Sequence Viewer  
  CAA57792 (Get FASTA)   NCBI Sequence Viewer  
  EDL85314 (Get FASTA)   NCBI Sequence Viewer  
  P00787 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_072119   ⟸   NM_022597
- Peptide Label: preproprotein
- UniProtKB: Q6IN22 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014178   ⟸   ENSRNOT00000014177
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00787-F1-model_v2 AlphaFold P00787 1-339 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699775
Promoter ID:EPDNEW_R10297
Type:initiation region
Description:cathepsin B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01546,316,798 - 46,316,858EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621509 AgrOrtholog
BioCyc Gene G2FUF-13438 BioCyc
Ensembl Genes ENSRNOG00000010331 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014178 ENTREZGENE
  ENSRNOP00000014178.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014177 ENTREZGENE
  ENSRNOT00000014177.6 UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Propeptide_C1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64529 UniProtKB/TrEMBL
Pfam Peptidase_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Propeptide_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ctsb PhenoGen
SMART Pept_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Ctsb  cathepsin B      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ctsb  cathepsin B      Symbol and Name status set to provisional 70820 PROVISIONAL