Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Ctsb (cathepsin B) Rattus norvegicus
Analyze
Symbol: Ctsb
Name: cathepsin B
Description: Exhibits several functions, including cysteine-type endopeptidase activity; kininogen binding activity; and protein self-association. Involved in several processes, including cellular response to mechanical stimulus; response to ethanol; and response to interleukin-4. Localizes to several cellular components, including the apical plasma membrane; external side of plasma membrane; and sarcolemma. Colocalizes with the caveola and perinuclear region of cytoplasm. Used to study hepatocellular carcinoma and malignant glioma. Biomarker of several diseases, including cerebrovascular disease (multiple); fascioliasis; fatty liver disease; polycystic kidney disease; and renal tubular acidosis. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B); PARTICIPATES IN chaperone mediated autophagy pathway; antigen processing and presentation pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cathepsin B1; RSG-2
Orthologs:
Homo sapiens (human) : CTSB (cathepsin B)  HGNC  Alliance
Mus musculus (house mouse) : Ctsb (cathepsin B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ctsb (cathepsin B)
Pan paniscus (bonobo/pygmy chimpanzee) : CTSB (cathepsin B)
Canis lupus familiaris (dog) : CTSB (cathepsin B)
Sus scrofa (pig) : CTSB (cathepsin B)
Chlorocebus sabaeus (African green monkey) : CTSB (cathepsin B)
Heterocephalus glaber (naked mole-rat) : Ctsb (cathepsin B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01546,316,741 - 46,337,613 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,316,741 - 46,337,612 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01550,081,535 - 50,102,407 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,402,829 - 42,423,701 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11542,418,600 - 42,439,400 (+)NCBI
Celera1537,073,910 - 37,094,782 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Ctsb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621509
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.