Adora1 (adenosine A1 receptor) - Rat Genome Database

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Gene: Adora1 (adenosine A1 receptor) Rattus norvegicus
Symbol: Adora1
Name: adenosine A1 receptor
RGD ID: 2048
Description: Enables several functions, including G protein-coupled adenosine receptor activity; G-protein beta/gamma-subunit complex binding activity; and heterotrimeric G-protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of lipid catabolic process; and regulation of secretion. Located in several cellular components, including axon; basolateral plasma membrane; and presynaptic active zone. Is active in calyx of Held; postsynaptic membrane; and presynaptic membrane. Used to study cerebral infarction; hypertension; lung disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA1 (adenosine A1 receptor); INTERACTS WITH (+)-pilocarpine; (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; 1,4-dithiothreitol.
Type: protein-coding
Previously known as: adenosine receptor A1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Adora1em3Mcwi   Adora1em4Mcwi  
Genetic Models: SS-Adora1em4Mcwi SS-Adora1em3Mcwi
Candidate Gene For: Bp328
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81348,210,922 - 48,247,826 (-)NCBIGRCr8
mRatBN7.21345,658,872 - 45,695,821 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,658,872 - 45,695,801 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1348,270,569 - 48,302,744 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,558,626 - 49,590,806 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,823,488 - 46,855,595 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,042,111 - 51,076,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,042,248 - 51,076,852 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01356,097,883 - 56,132,155 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,160,292 - 47,192,804 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11347,173,084 - 47,207,198 (-)NCBI
Celera1345,990,556 - 46,022,753 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(1->4)-beta-D-glucan  (ISO)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
adenosine  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
citalopram  (ISO)
clofibrate  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
corticosterone  (ISO)
cytidine  (EXP)
diallyl disulfide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl pyrocarbonate  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
dithionitrobenzoic acid  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edaravone  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
fluoxetine  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-aminobutyric acid  (EXP)
gefitinib  (ISO)
glycerol  (EXP)
hydrogen peroxide  (EXP,ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
ketoconazole  (EXP)
L-1,4-dithiothreitol  (EXP)
L-cysteine  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP,ISO)
methylmercury chloride  (ISO)
mianserin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
morphine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
orphenadrine  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
picene  (ISO)
pioglitazone  (ISO)
prazosin  (EXP)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
theophylline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
uridine  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
XL147  (ISO)
zinc dichloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IMP)
cognition  (IMP)
detection of temperature stimulus involved in sensory perception of pain  (IMP)
excitatory postsynaptic potential  (IMP,ISO)
fatty acid homeostasis  (IDA)
G protein-coupled adenosine receptor signaling pathway  (IEA)
G protein-coupled receptor signaling pathway  (IBA,IDA)
leukocyte migration  (ISO)
lipid catabolic process  (IMP)
long-term synaptic depression  (ISO)
mucus secretion  (ISO)
negative regulation of acute inflammatory response  (IDA)
negative regulation of apoptotic process  (IDA)
negative regulation of blood pressure  (IMP)
negative regulation of cell population proliferation  (IDA)
negative regulation of circadian sleep/wake cycle, non-REM sleep  (IMP)
negative regulation of circadian sleep/wake cycle, sleep  (IDA)
negative regulation of glutamate secretion  (IDA)
negative regulation of hormone secretion  (IMP)
negative regulation of inflammatory response  (ISO)
negative regulation of leukocyte migration  (ISO)
negative regulation of lipid catabolic process  (IDA)
negative regulation of long-term synaptic depression  (ISO)
negative regulation of long-term synaptic potentiation  (IMP)
negative regulation of mucus secretion  (ISO)
negative regulation of neurotrophin production  (IMP)
negative regulation of synaptic transmission, GABAergic  (IDA,IMP)
negative regulation of synaptic transmission, glutamatergic  (IDA)
negative regulation of systemic arterial blood pressure  (IDA)
positive regulation of blood pressure  (IDA)
positive regulation of epidermal growth factor-activated receptor activity  (IMP)
positive regulation of lipid catabolic process  (IDA)
positive regulation of MAPK cascade  (IDA)
positive regulation of nucleoside transport  (IDA)
positive regulation of peptide secretion  (IMP)
positive regulation of potassium ion transport  (IDA)
positive regulation of protein dephosphorylation  (IDA)
positive regulation of systemic arterial blood pressure  (IMP)
protein targeting to membrane  (IMP)
regulation of cardiac muscle cell contraction  (IDA)
regulation of cardiac muscle contraction  (IMP)
regulation of glomerular filtration  (ISO)
regulation of presynaptic cytosolic calcium ion concentration  (EXP,IDA)
regulation of respiratory gaseous exchange by nervous system process  (IMP)
regulation of sensory perception of pain  (ISO)
response to auditory stimulus  (ISO)
response to hypoxia  (IMP)
response to inorganic substance  (ISO)
response to purine-containing compound  (ISO)
temperature homeostasis  (IMP)
triglyceride homeostasis  (IDA)
vasoconstriction  (ISO)
vasodilation  (IDA)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Ischaemic and pharmacological preconditionings protect liver via adenosine and redox status following hepatic ischaemia/reperfusion in rats. Ajamieh HH, etal., Clin Sci (Lond). 2008 Jul;115(2):69-77.
2. Moderate cerebral venous congestion induces rapid cerebral protection via adenosine A1 receptor activation. Akaiwa K, etal., Brain Res. 2006 Nov 29;1122(1):47-55. Epub 2006 Oct 24.
3. Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices. Almeida T, etal., Neuroscience. 2003;122(1):111-21.
4. Revista española de cardiología Alvarado-Tapias E, etal., Rev Esp Cardiol. 2010 Apr;63(4):478-82.
5. Effects of the adenosine A1 receptor inhibitor FK 838 on proximal tubular fluid output in rats. Bak M and Thomsen K, Nephrol Dial Transplant. 2004 May;19(5):1077-82. Epub 2004 Feb 19.
6. Protective effect of adenosine in diabetic neuropathic pain is mediated through adenosine A1-receptors. Balasubramanyan S and Sharma SS, Indian J Physiol Pharmacol. 2008 Jul-Sep;52(3):233-42.
7. Differences in the expression of the adenosine A1 receptor in adipose tissue of obese black and white women. Barakat H, etal., J Clin Endocrinol Metab. 2006 May;91(5):1882-6. Epub 2006 Feb 28.
8. Respiratory and body temperature modulation by adenosine A1 receptors in the anteroventral preoptic region during normoxia and hypoxia. Barros RC, etal., Respir Physiol Neurobiol. 2006 Sep 28;153(2):115-25. Epub 2005 Dec 13.
9. Tumor necrosis factor-alpha impairs the recovery of synaptic transmission from hypoxia in rat hippocampal slices. Batti L and O'Connor JJ, J Neuroimmunol. 2010 Jan 25;218(1-2):21-7. Epub 2009 Nov 25.
10. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
11. Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects. Brown RA, etal., Eur Respir J. 2008 Feb;31(2):311-9. Epub 2007 Oct 24.
12. Activation of adenosine A1 receptors by drugs to lower plasma glucose in streptozotocin-induced diabetic rats. Cheng JT, etal., Auton Neurosci. 2000 Oct 2;83(3):127-33.
13. Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. Ciruela F, etal., J Neurosci. 2006 Feb 15;26(7):2080-7.
14. Overexpression of the A1 adenosine receptor in adipose tissue protects mice from obesity-related insulin resistance. Dong Q, etal., Diabetes Obes Metab. 2001 Oct;3(5):360-6.
15. Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats. Duarte JM, etal., Neurochem Int. 2006 Jan;48(2):144-50. Epub 2005 Oct 26.
16. ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors. Duflot S, etal., Mol Cell Biol. 2004 Apr;24(7):2710-9.
17. Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse. Fenton RA, etal., Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H718-25. Epub 2009 Jun 12.
18. Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes. Garg V, etal., Cardiovasc Res. 2009 Apr 1;82(1):51-8. doi: 10.1093/cvr/cvp039. Epub 2009 Jan 30.
19. The role of the basal forebrain adenosine receptors in sleep homeostasis. Gass N, etal., Neuroreport. 2009 Jul 15;20(11):1013-8.
20. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
21. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
22. Study of an adenosine A1 receptor agonist on trigeminally evoked dural blood vessel dilation in the anaesthetized rat. Honey AC, etal., Cephalalgia. 2002 May;22(4):260-4.
23. Adenosine A1 receptor agonists reduce hyperalgesia after spinal cord injury in rats. Horiuchi H, etal., Spinal Cord. 2010 Sep;48(9):685-90. Epub 2010 Jan 12.
24. Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneously hypertensive rat complicated with hyperglycemia. Ishikawa J, etal., Diabetes Res Clin Pract. 1998 Jan;39(1):3-9.
25. Expression of adenosine receptors in the preglomerular microcirculation. Jackson EK, etal., Am J Physiol Renal Physiol 2002 Jul;283(1):F41-51.
26. Adenosine A1 receptor-mediated presynaptic inhibition of GABAergic transmission in immature rat hippocampal CA1 neurons. Jeong HJ, etal., J Neurophysiol. 2003 Mar;89(3):1214-22.
27. Administration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high cervical spinal cord injured rats. Kajana S and Goshgarian HG, Exp Neurol. 2008 Apr;210(2):671-80. Epub 2008 Jan 5.
28. Activation of p38 mitogen-activated protein kinase is required for in vivo brain-derived neurotrophic factor production in the rat hippocampus. Katoh-Semba R, etal., Neuroscience. 2009 Sep 29;163(1):352-61. Epub 2009 Jun 10.
29. Contribution of NO, ATP-sensitive K+ channels and prostaglandins to adenosine receptor agonists-induced relaxation of the rat tail artery. Kedzior K, etal., Pharmacol Rep. 2009 Mar-Apr;61(2):330-4.
30. Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. Kim SH, etal., Respir Med. 2009 Mar;103(3):356-63. Epub 2008 Nov 18.
31. Adenosine A(1) receptor-mediated presynaptic inhibition at the calyx of Held of immature rats. Kimura M, etal., J Physiol. 2003 Dec 1;553(Pt 2):415-26. doi: 10.1113/jphysiol.2003.048371. Epub 2003 Sep 8.
32. Adenosine A1 receptor down-regulation in mothers and fetal brain after caffeine and theophylline treatments to pregnant rats. Leon D, etal., J Neurochem 2002 Aug;82(3):625-34.
33. Tonic activity of the rat adipocyte A1-adenosine receptor. Liang HX, etal., Br J Pharmacol. 2002 Mar;135(6):1457-66.
34. Antiadrenergic effects of adenosine A(1) receptor-mediated protein phosphatase 2a activation in the heart. Liu Q and Hofmann PA, Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1314-21.
35. Cloning and expression of an A1 adenosine receptor from rat brain. Mahan LC, etal., Mol Pharmacol 1991 Jul;40(1):1-7.
36. Sleep fragmentation impairs ventilatory long-term facilitation via adenosine A1 receptors. McGuire M, etal., J Physiol. 2008 Nov 1;586(Pt 21):5215-29. Epub 2008 Sep 11.
37. Effects on sleep of microdialysis of adenosine A1 and A2a receptor analogs into the lateral preoptic area of rats. Methippara MM, etal., Am J Physiol Regul Integr Comp Physiol. 2005 Dec;289(6):R1715-23. Epub 2005 Aug 18.
38. Early dyspnoea relief in acute heart failure: prevalence, association with mortality, and effect of rolofylline in the PROTECT Study. Metra M, etal., Eur Heart J. 2011 Mar 8.
39. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
40. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
41. Adenosine receptor A1 regulates polymorphonuclear cell trafficking and microvascular permeability in lipopolysaccharide-induced lung injury. Ngamsri KC, etal., J Immunol. 2010 Oct 1;185(7):4374-84. Epub 2010 Aug 20.
42. Mechanisms of interaction between adenosine receptor subtypes on hippocampal serotonin release Okada M, etal., Nihon Shinkei Seishin Yakurigaku Zasshi 2002 Apr;22(2):61-9.
43. Truncation of the A1 adenosine receptor reveals distinct roles of the membrane-proximal carboxyl terminus in receptor folding and G protein coupling. Pankevych H, etal., J Biol Chem. 2003 Aug 8;278(32):30283-93. Epub 2003 May 22.
44. Adenosine A1 receptor expression during the transition from compensated pressure overload hypertrophy to heart failure. Perlini S, etal., J Hypertens. 2007 Feb;25(2):449-54.
45. Differential expression of adenosine A1 and A2A receptors after upper cervical (C2) spinal cord hemisection in adult rats. Petrov T, etal., J Spinal Cord Med. 2007;30(4):331-7.
46. Expression cloning of rat cerebellar adenosine A1 receptor by coupling to Kir channels. Pfaff T and Karschin A, Neuroreport 1997 Jul 28;8(11):2455-60.
47. Subcellular distributions of adenosine A1 and A2A receptors in the rat dorsomedial nucleus of the solitary tract at the level of the area postrema. Pickel VM, etal., Synapse. 2006 Dec 1;60(7):496-509.
48. Neuroinflammation after neonatal hypoxia-ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult. Pimentel VC, etal., Mol Cell Biochem. 2015 May;403(1-2):169-77. doi: 10.1007/s11010-015-2347-9. Epub 2015 Feb 27.
49. Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorder. Pires VA, etal., Behav Pharmacol. 2009 Mar;20(2):134-45.
50. Involvement of A1 adenosine receptors in altered vascular responses and inflammation in an allergic mouse model of asthma. Ponnoth DS, etal., Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H81-7. Epub 2010 Apr 16.
51. Short-term metabolic and haemodynamic effects of GR79236 in normal and fructose-fed rats. Qu X, etal., Eur J Pharmacol. 1997 Nov 12;338(3):269-76.
52. Subcellular localization of adenosine A(1) receptors in nerve terminals and synapses of the rat hippocampus. Rebola N, etal., Brain Res. 2003 Oct 10;987(1):49-58.
53. Adenosine-regulated cell proliferation in pituitary folliculostellate and endocrine cells: differential roles for the A(1) and A(2B) adenosine receptors. Rees DA, etal., Endocrinology 2002 Jun;143(6):2427-36.
54. A1 adenosine receptor overexpression attenuates ischemia-reperfusion-induced apoptosis and caspase 3 activity. Regan SE, etal., Am J Physiol Heart Circ Physiol. 2003 Mar;284(3):H859-66.
55. GOA pipeline RGD automated data pipeline
56. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
57. The heat shock cognate protein hsc73 assembles with A(1) adenosine receptors to form functional modules in the cell membrane. Sarrio S, etal., Mol Cell Biol. 2000 Jul;20(14):5164-74.
58. Characterization of adenosine-A1 receptor-mediated antilipolysis in rats by tissue microdialysis, 1H-spectroscopy, and glucose clamp studies. Schoelch C, etal., Diabetes. 2004 Jul;53(7):1920-6.
59. The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats. Schrier DJ, etal., J Immunol. 1990 Sep 15;145(6):1874-9.
60. Mechanisms mediating regional sympathoactivatory responses to stimulation of NTS A(1) adenosine receptors. Scislo TJ and O'Leary DS, Am J Physiol Heart Circ Physiol 2002 Oct;283(4):H1588-99.
61. A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury. Sun CX, etal., J Clin Invest. 2005 Jan;115(1):35-43.
62. Mediation of tubuloglomerular feedback by adenosine: evidence from mice lacking adenosine 1 receptors. Sun D, etal., Proc Natl Acad Sci U S A 2001 Aug 14;98(17):9983-8.
63. Effects of adenosine A1 receptor antagonism on lipogenesis and lipolysis in isolated rat adipocytes. Szkudelski T, etal., Physiol Res. 2009;58(6):863-71. Epub 2008 Dec 17.
64. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
65. A1 adenosine receptor activation induces ventriculomegaly and white matter loss. Turner CP, etal., Neuroreport. 2002 Jul 2;13(9):1199-204.
66. A new adenosine subtype-1 receptor antagonist, FK-838, attenuates salt-induced hypertension in Dahl salt-sensitive rats. Uehara Y, etal., Am J Hypertens. 1995 Dec;8(12 Pt 1):1189-99.
67. Adenosine A(1) receptors determine glomerular hyperfiltration and the salt paradox in early streptozotocin diabetes mellitus. Vallon V, etal., Nephron Physiol. 2009;111(3):p30-8. Epub 2009 Mar 10.
68. The role of adenosine in the early respiratory and cardiovascular changes evoked by chronic hypoxia in the rat. Walsh MP and Marshall JM, J Physiol. 2006 Aug 15;575(Pt 1):277-89. Epub 2006 May 11.
69. The role of adenosine-related genes variants in susceptibility to essential hypertension. Wright K, etal., J Hypertens. 2004 Aug;22(8):1519-22.
70. Adenosine A(1) receptor-mediated transactivation of the EGF receptor produces a neuroprotective effect on cortical neurons in vitro. Xie KQ, etal., Acta Pharmacol Sin. 2009 Jul;30(7):889-98.
71. Adenosine A(1) receptors selectively target protein kinase C isoforms to the caveolin-rich plasma membrane in cardiac myocytes. Yang Z, etal., Biochim Biophys Acta. 2009 Dec;1793(12):1868-75. Epub 2009 Oct 30.
72. Role of adenosine A1 receptor in the regulation of gastrin release. Yip L, etal., J Pharmacol Exp Ther. 2004 Aug;310(2):477-87. Epub 2004 Mar 24.
73. Agonist-promoted heteromeric oligomerization between adenosine A(1) and P2Y(1) receptors in living cells. Yoshioka K, etal., FEBS Lett. 2002 Jul 17;523(1-3):147-51.
74. Hetero-oligomerization of adenosine A1 receptors with P2Y1 receptors in rat brains. Yoshioka K, etal., FEBS Lett. 2002 Nov 6;531(2):299-303.
75. Heteromeric association creates a P2Y-like adenosine receptor. Yoshioka K, etal., Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7617-22. Epub 2001 Jun 5.
76. Adenosine-stimulated atrial natriuretic peptide release through A1 receptor subtype. Yuan K, etal., Hypertension. 2005 Dec;46(6):1381-7. Epub 2005 Nov 14.
77. Role of renal medullary adenosine in the control of blood flow and sodium excretion. Zou AP, etal., Am J Physiol 1999 Mar;276(3 Pt 2):R790-8.
78. Effect of chronic salt loading on adenosine metabolism and receptor expression in renal cortex and medulla in rats. Zou AP, etal., Hypertension 1999 Jan;33(1 Pt 2):511-6.
Additional References at PubMed
PMID:1658635   PMID:11952152   PMID:12106679   PMID:12381818   PMID:12697266   PMID:12789654   PMID:12821393   PMID:12974671   PMID:15057516   PMID:15241185   PMID:15255939   PMID:15283758  
PMID:15308482   PMID:15681707   PMID:15719142   PMID:16055264   PMID:16683708   PMID:16696848   PMID:16707501   PMID:17254024   PMID:17372967   PMID:17428973   PMID:17497078   PMID:17512911  
PMID:17516542   PMID:17548208   PMID:17622285   PMID:17664389   PMID:17965278   PMID:17982009   PMID:18007182   PMID:18052983   PMID:18054436   PMID:18163981   PMID:18313046   PMID:18322364  
PMID:18360306   PMID:18397365   PMID:18480183   PMID:18584206   PMID:18849358   PMID:18940592   PMID:18947392   PMID:19110076   PMID:19139607   PMID:19146833   PMID:19212009   PMID:19344634  
PMID:19427366   PMID:19477241   PMID:19619617   PMID:19781535   PMID:19782066   PMID:19822132   PMID:19908252   PMID:19995597   PMID:20054814   PMID:20109537   PMID:20237259   PMID:20500549  
PMID:20730620   PMID:21061016   PMID:21186374   PMID:21335481   PMID:21764782   PMID:21878793   PMID:21983553   PMID:21993001   PMID:22064330   PMID:22126400   PMID:22150479   PMID:22233927  
PMID:22323824   PMID:22389722   PMID:22449383   PMID:23106524   PMID:23221044   PMID:23598433   PMID:23613526   PMID:23783558   PMID:23810661   PMID:24014158   PMID:24259587   PMID:24309216  
PMID:24352876   PMID:24513151   PMID:24845382   PMID:25232008   PMID:25251152   PMID:25401477   PMID:25661317   PMID:25667928   PMID:25907806   PMID:26010290   PMID:26658041   PMID:26709861  
PMID:26728617   PMID:27005940   PMID:27060487   PMID:27134041   PMID:27301321   PMID:27301342   PMID:27792010   PMID:28446460   PMID:28882563   PMID:29149028   PMID:29380238   PMID:29514102  
PMID:31346513   PMID:31868057   PMID:31909494   PMID:33174009   PMID:33391483   PMID:34830353   PMID:35653908   PMID:37330931   PMID:37714421  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81348,210,922 - 48,247,826 (-)NCBIGRCr8
mRatBN7.21345,658,872 - 45,695,821 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,658,872 - 45,695,801 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1348,270,569 - 48,302,744 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,558,626 - 49,590,806 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,823,488 - 46,855,595 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,042,111 - 51,076,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,042,248 - 51,076,852 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01356,097,883 - 56,132,155 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,160,292 - 47,192,804 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11347,173,084 - 47,207,198 (-)NCBI
Celera1345,990,556 - 46,022,753 (-)NCBICelera
Cytogenetic Map13q13NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381203,127,726 - 203,167,405 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1203,090,654 - 203,167,405 (+)EnsemblGRCh38hg38GRCh38
GRCh371203,096,854 - 203,136,533 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,363,459 - 201,403,156 (+)NCBINCBI36Build 36hg18NCBI36
Build 341199,791,438 - 199,868,189NCBI
Celera1176,226,082 - 176,265,774 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1174,262,408 - 174,301,662 (+)NCBIHuRef
CHM1_11204,519,171 - 204,558,852 (+)NCBICHM1_1
T2T-CHM13v2.01202,390,478 - 202,430,156 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391134,126,953 - 134,163,195 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,126,963 - 134,163,169 (-)EnsemblGRCm39 Ensembl
GRCm381134,199,215 - 134,235,457 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,199,223 - 134,235,431 (-)EnsemblGRCm38mm10GRCm38
MGSCv371136,095,799 - 136,132,008 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361136,015,633 - 136,051,842 (-)NCBIMGSCv36mm8
Celera1136,811,737 - 136,847,932 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.15NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540639,149,689 - 39,187,688 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540639,148,811 - 39,183,577 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2146,210,718 - 46,250,302 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1146,178,264 - 46,216,877 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01178,728,751 - 178,769,066 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11183,023,466 - 183,063,760 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1183,023,466 - 183,063,760 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1744,819 - 74,217 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl744,820 - 73,051 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha7100,548 - 128,787 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0755,302 - 84,711 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl755,305 - 83,603 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1743,539 - 71,770 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.07153,116 - 181,315 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.07175,551 - 203,789 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440934472,195,448 - 72,227,851 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365671,429,817 - 1,462,532 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365671,430,128 - 1,508,626 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl9113,835,921 - 113,872,365 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19113,835,279 - 113,875,899 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29125,293,656 - 125,331,581 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12526,180,898 - 26,221,424 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2526,182,446 - 26,220,776 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605526,957,323 - 26,997,269 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248077,674,927 - 7,705,051 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248077,674,164 - 7,705,736 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Adora1
165 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir150rno-miR-150-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:223
Count of miRNA genes:139
Interacting mature miRNAs:167
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134343790447841255Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
12879436Bp395Blood pressure QTL 395arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134463918245700190Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879472Bp399Blood pressure QTL 399arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134522835847841255Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,689,077 - 45,689,314 (+)MAPPERmRatBN7.2
Rnor_6.01351,070,083 - 51,070,319NCBIRnor6.0
Rnor_5.01356,125,418 - 56,125,654UniSTSRnor5.0
RGSC_v3.41347,187,081 - 47,187,317UniSTSRGSC3.4
Celera1346,017,042 - 46,017,266UniSTS
Cytogenetic Map13q13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,661,914 - 45,662,013 (+)MAPPERmRatBN7.2
Rnor_6.01351,042,925 - 51,043,023NCBIRnor6.0
Rnor_5.01356,098,605 - 56,098,703UniSTSRnor5.0
RGSC_v3.41347,159,719 - 47,159,817UniSTSRGSC3.4
Celera1345,989,983 - 45,990,081UniSTS
Cytogenetic Map13q13UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,662,660 - 45,662,839 (+)MAPPERmRatBN7.2
Rnor_6.01351,043,671 - 51,043,849NCBIRnor6.0
Rnor_5.01356,099,351 - 56,099,529UniSTSRnor5.0
RGSC_v3.41347,160,465 - 47,160,643UniSTSRGSC3.4
Celera1345,990,729 - 45,990,907UniSTS
Cytogenetic Map13q13UniSTS

Genetic Models
This gene Adora1 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 12 1 9 50 13
Low 3 31 42 27 10 27 8 11 14 33 25 11 8
Below cutoff 10 10 10 10 2 3


RefSeq Acc Id: ENSRNOT00000004602   ⟹   ENSRNOP00000004602
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1345,658,872 - 45,695,801 (-)Ensembl
Rnor_6.0 Ensembl1351,042,248 - 51,076,165 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078993   ⟹   ENSRNOP00000073958
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1351,043,334 - 51,076,852 (-)Ensembl
RefSeq Acc Id: NM_017155   ⟹   NP_058851
Rat AssemblyChrPosition (strand)Source
GRCr81348,214,523 - 48,246,831 (-)NCBI
mRatBN7.21345,662,488 - 45,694,801 (-)NCBI
Rnor_6.01351,043,498 - 51,075,806 (-)NCBI
Rnor_5.01356,097,883 - 56,132,155 (-)NCBI
RGSC_v3.41347,160,292 - 47,192,804 (-)RGD
Celera1345,990,556 - 46,022,753 (-)RGD
RefSeq Acc Id: XM_006249859   ⟹   XP_006249921
Rat AssemblyChrPosition (strand)Source
GRCr81348,210,922 - 48,247,804 (-)NCBI
mRatBN7.21345,658,872 - 45,695,821 (-)NCBI
Rnor_6.01351,042,111 - 51,076,906 (-)NCBI
Rnor_5.01356,097,883 - 56,132,155 (-)NCBI
RefSeq Acc Id: XM_039090617   ⟹   XP_038946545
Rat AssemblyChrPosition (strand)Source
GRCr81348,210,922 - 48,247,293 (-)NCBI
mRatBN7.21345,658,872 - 45,695,595 (-)NCBI
RefSeq Acc Id: XM_039090618   ⟹   XP_038946546
Rat AssemblyChrPosition (strand)Source
GRCr81348,210,922 - 48,247,804 (-)NCBI
mRatBN7.21345,658,872 - 45,695,821 (-)NCBI
RefSeq Acc Id: XM_039090619   ⟹   XP_038946547
Rat AssemblyChrPosition (strand)Source
GRCr81348,210,922 - 48,247,293 (-)NCBI
mRatBN7.21345,658,872 - 45,695,596 (-)NCBI
RefSeq Acc Id: XM_039090620   ⟹   XP_038946548
Rat AssemblyChrPosition (strand)Source
GRCr81348,210,922 - 48,247,826 (-)NCBI
mRatBN7.21345,658,872 - 45,695,821 (-)NCBI
RefSeq Acc Id: XM_063272203   ⟹   XP_063128273
Rat AssemblyChrPosition (strand)Source
GRCr81348,210,922 - 48,247,294 (-)NCBI
RefSeq Acc Id: NP_058851   ⟸   NM_017155
- UniProtKB: P25099 (UniProtKB/Swiss-Prot),   A6ICB1 (UniProtKB/TrEMBL),   O08766 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249921   ⟸   XM_006249859
- Peptide Label: isoform X1
- UniProtKB: P25099 (UniProtKB/Swiss-Prot),   A6ICB1 (UniProtKB/TrEMBL),   O08766 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004602   ⟸   ENSRNOT00000004602
RefSeq Acc Id: ENSRNOP00000073958   ⟸   ENSRNOT00000078993
RefSeq Acc Id: XP_038946548   ⟸   XM_039090620
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038946546   ⟸   XM_039090618
- Peptide Label: isoform X1
- UniProtKB: P25099 (UniProtKB/Swiss-Prot),   A6ICB1 (UniProtKB/TrEMBL),   O08766 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946547   ⟸   XM_039090619
- Peptide Label: isoform X1
- UniProtKB: P25099 (UniProtKB/Swiss-Prot),   A6ICB1 (UniProtKB/TrEMBL),   O08766 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946545   ⟸   XM_039090617
- Peptide Label: isoform X1
- UniProtKB: P25099 (UniProtKB/Swiss-Prot),   A6ICB1 (UniProtKB/TrEMBL),   O08766 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128273   ⟸   XM_063272203
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25099-F1-model_v2 AlphaFold P25099 1-326 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698833
Promoter ID:EPDNEW_R9352
Type:multiple initiation site
Description:adenosine A1 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01351,076,239 - 51,076,299EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2048 AgrOrtholog
BioCyc Gene G2FUF-18247 BioCyc
Ensembl Genes ENSRNOG00000003442 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055022024 UniProtKB/Swiss-Prot
  ENSRNOG00060017875 UniProtKB/Swiss-Prot
  ENSRNOG00065019876 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004602.3 UniProtKB/Swiss-Prot
  ENSRNOT00055037822 UniProtKB/Swiss-Prot
  ENSRNOT00060030631 UniProtKB/Swiss-Prot
  ENSRNOT00065033490 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Adeno_A1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenosn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29290 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adora1 PhenoGen
  ADENOSINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003442 RatGTEx
  ENSRNOG00055022024 RatGTEx
  ENSRNOG00060017875 RatGTEx
  ENSRNOG00065019876 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC203917
  AA1R_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Adora1  adenosine A1 receptor    adenosine A1 receptor   Name updated 625702 APPROVED
2002-06-10 Adora1  adenosine A1 receptor       Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) increases urine flow and sodium excretion 628573
gene_expression expressed in the cerebellum 631744
gene_expression expressed in many regions of the brain including cortex, cerebellum, hippocampus, and thalamus 69743
gene_expression distributed along nephron and in outer medullary desceding vasa recta; localized to specific nephron segments, including glomeruli, thick ascending limb and papillary collecting duct 628573
gene_expression expressed in renal cortex and medulla 628573
gene_expression protein and mRNA expressed at high levels in the preglomerular microvessels (PGMVs) of kidney 628573
gene_function inhibits adenylyl cyclase activity 69743
gene_function antidiuretic and antinatriuretic adenosine receptor 628573
gene_process involved in the regulation of arterial pressure and heart rate 631806
gene_process plays a role in adaptation in the kidney to promote sodium excretion 628562
gene_process administration of agonists cause vasoconstriction of the preglomerular microvessels (PGMVs) and potentiation of angiotensin II-induced changes in renal vascular resistance, reduction of the glomerular filtration rate and inhibition renin release 628573
gene_process may mediate antinatriuretic effects of adenosine 628573
gene_product member of the G-protein coupled receptor family 631744
gene_protein encodes a protein sequence of 326 amino acids 631744
gene_protein 38 kDa 628351
gene_protein 39 kDa 628573
gene_regulation a high salt diet (4% NaCl for 3 weeks) decreases mRNA expression 628573
gene_transcript mRNA transcripts of 5.6 and 3.1 kb are detected 69743