Adora1 (adenosine A1 receptor) - Rat Genome Database

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Gene: Adora1 (adenosine A1 receptor) Rattus norvegicus
Analyze
Symbol: Adora1
Name: adenosine A1 receptor
RGD ID: 2048
Description: Exhibits several functions, including G protein-coupled adenosine receptor activity; G-protein beta/gamma-subunit complex binding activity; and heterotrimeric G-protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of protein modification process; and regulation of secretion. Localizes to several cellular components, including axon; basolateral plasma membrane; and integral component of synaptic membrane. Used to study cerebral infarction; hypertension; lung disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA1 (adenosine A1 receptor); INTERACTS WITH (+)-pilocarpine; (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; 1,4-dithiothreitol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: adenosine receptor A1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Adora1em3Mcwi   Adora1em4Mcwi  
Genetic Models: SS-Adora1em4Mcwi SS-Adora1em3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21345,658,872 - 45,695,821 (-)NCBI
Rnor_6.0 Ensembl1351,042,248 - 51,076,852 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01351,042,111 - 51,076,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01356,097,883 - 56,132,155 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,160,292 - 47,192,804 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11347,173,084 - 47,207,198 (-)NCBI
Celera1345,990,556 - 46,022,753 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
adenosine  (EXP,ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
caffeine  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
citalopram  (ISO)
clofibrate  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
corticosterone  (ISO)
cytidine  (EXP)
dibutyl phthalate  (EXP,ISO)
diethyl pyrocarbonate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dithionitrobenzoic acid  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
DPCPX  (EXP,ISO)
edaravone  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
fluoxetine  (ISO)
folic acid  (ISO)
furan  (EXP)
gamma-aminobutyric acid  (EXP)
gefitinib  (ISO)
glycerol  (EXP)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
L-1,4-dithiothreitol  (EXP)
L-cysteine  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
maneb  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP,ISO)
methylmercury chloride  (ISO)
mianserin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
morphine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
orphenadrine  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
picene  (ISO)
pioglitazone  (ISO)
prazosin  (EXP)
resveratrol  (EXP)
sarin  (ISO)
SB 431542  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
theophylline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
uridine  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
XL147  (ISO)
zinc dichloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPKK activity  (IDA)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IMP)
cognition  (IMP)
detection of temperature stimulus involved in sensory perception of pain  (IMP)
excitatory postsynaptic potential  (IMP,ISO)
fatty acid homeostasis  (IDA)
G protein-coupled adenosine receptor signaling pathway  (IEA)
G protein-coupled receptor signaling pathway  (IDA)
lipid catabolic process  (IMP)
negative regulation of acute inflammatory response  (IDA)
negative regulation of apoptotic process  (IDA)
negative regulation of blood pressure  (IMP)
negative regulation of cell population proliferation  (IDA)
negative regulation of circadian sleep/wake cycle, non-REM sleep  (IMP)
negative regulation of circadian sleep/wake cycle, sleep  (IDA)
negative regulation of glutamate secretion  (IDA)
negative regulation of heart contraction  (IMP)
negative regulation of hormone secretion  (IMP)
negative regulation of inflammatory response  (ISO)
negative regulation of leukocyte migration  (ISO)
negative regulation of lipid catabolic process  (IDA)
negative regulation of long-term synaptic depression  (ISO)
negative regulation of long-term synaptic potentiation  (IMP)
negative regulation of mucus secretion  (ISO)
negative regulation of neurotrophin production  (IMP)
negative regulation of renal sodium excretion  (IMP)
negative regulation of synaptic transmission, GABAergic  (IDA,IMP)
negative regulation of synaptic transmission, glutamatergic  (IDA)
negative regulation of systemic arterial blood pressure  (IDA)
positive regulation of blood pressure  (IDA)
positive regulation of epidermal growth factor-activated receptor activity  (IMP)
positive regulation of lipid catabolic process  (IDA)
positive regulation of neuron death  (IDA)
positive regulation of nucleoside transport  (IDA)
positive regulation of peptide secretion  (IMP)
positive regulation of potassium ion transport  (IDA)
positive regulation of protein dephosphorylation  (IDA)
positive regulation of systemic arterial blood pressure  (IMP)
protein targeting to membrane  (IMP)
regulation of cardiac muscle cell contraction  (IDA)
regulation of cardiac muscle contraction  (IMP)
regulation of glomerular filtration  (ISO)
regulation of presynaptic cytosolic calcium ion concentration  (IEA)
regulation of respiratory gaseous exchange by nervous system process  (IMP)
regulation of sensory perception of pain  (ISO)
relaxation of vascular associated smooth muscle  (IMP)
response to auditory stimulus  (ISO)
response to hypoxia  (IMP)
temperature homeostasis  (IMP)
triglyceride homeostasis  (IDA)
vasoconstriction  (ISO)
vasodilation  (IDA)

References

References - curated
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Additional References at PubMed
PMID:1658635   PMID:11952152   PMID:12106679   PMID:12381818   PMID:12697266   PMID:12789654   PMID:12821393   PMID:12974671   PMID:15057516   PMID:15241185   PMID:15255939   PMID:15283758  
PMID:15308482   PMID:15681707   PMID:15719142   PMID:16055264   PMID:16683708   PMID:16696848   PMID:16707501   PMID:17254024   PMID:17372967   PMID:17428973   PMID:17497078   PMID:17512911  
PMID:17516542   PMID:17548208   PMID:17622285   PMID:17664389   PMID:17965278   PMID:17982009   PMID:18007182   PMID:18052983   PMID:18054436   PMID:18163981   PMID:18313046   PMID:18322364  
PMID:18360306   PMID:18397365   PMID:18480183   PMID:18584206   PMID:18849358   PMID:18940592   PMID:18947392   PMID:19110076   PMID:19139607   PMID:19146833   PMID:19212009   PMID:19344634  
PMID:19427366   PMID:19477241   PMID:19619617   PMID:19781535   PMID:19782066   PMID:19822132   PMID:19908252   PMID:19995597   PMID:20054814   PMID:20109537   PMID:20237259   PMID:20500549  
PMID:20730620   PMID:21061016   PMID:21186374   PMID:21335481   PMID:21764782   PMID:21878793   PMID:21983553   PMID:21993001   PMID:22064330   PMID:22126400   PMID:22150479   PMID:22233927  
PMID:22323824   PMID:22389722   PMID:22449383   PMID:23106524   PMID:23221044   PMID:23598433   PMID:23613526   PMID:23783558   PMID:23810661   PMID:24014158   PMID:24259587   PMID:24309216  
PMID:24352876   PMID:24513151   PMID:24845382   PMID:25232008   PMID:25251152   PMID:25401477   PMID:25661317   PMID:25667928   PMID:25907806   PMID:26010290   PMID:26658041   PMID:26709861  
PMID:26728617   PMID:27005940   PMID:27060487   PMID:27134041   PMID:27301321   PMID:27301342   PMID:27792010   PMID:28446460   PMID:28882563   PMID:29149028   PMID:29380238   PMID:29514102  
PMID:31346513   PMID:31909494  


Genomics

Candidate Gene Status
Adora1 is a candidate Gene for QTL Bp328
Comparative Map Data
Adora1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21345,658,872 - 45,695,821 (-)NCBI
Rnor_6.0 Ensembl1351,042,248 - 51,076,852 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01351,042,111 - 51,076,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01356,097,883 - 56,132,155 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,160,292 - 47,192,804 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11347,173,084 - 47,207,198 (-)NCBI
Celera1345,990,556 - 46,022,753 (-)NCBICelera
Cytogenetic Map13q13NCBI
ADORA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1203,090,654 - 203,167,405 (+)EnsemblGRCh38hg38GRCh38
GRCh381203,127,705 - 203,167,405 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371203,096,854 - 203,136,533 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,363,459 - 201,403,156 (+)NCBINCBI36hg18NCBI36
Build 341199,791,438 - 199,868,189NCBI
Celera1176,226,082 - 176,265,774 (+)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1174,262,408 - 174,301,662 (+)NCBIHuRef
CHM1_11204,519,171 - 204,558,852 (+)NCBICHM1_1
Adora1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,126,953 - 134,163,195 (-)NCBIGRCm39mm39
GRCm39 Ensembl1134,126,961 - 134,163,169 (-)Ensembl
GRCm381134,199,215 - 134,235,457 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,199,223 - 134,235,431 (-)EnsemblGRCm38mm10GRCm38
MGSCv371136,095,799 - 136,132,008 (-)NCBIGRCm37mm9NCBIm37
MGSCv361136,015,633 - 136,051,842 (-)NCBImm8
Celera1136,811,737 - 136,847,932 (-)NCBICelera
Cytogenetic Map1E4NCBI
Adora1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540639,149,689 - 39,187,688 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540639,148,811 - 39,183,577 (+)NCBIChiLan1.0ChiLan1.0
ADORA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11183,023,466 - 183,063,760 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1183,023,466 - 183,063,760 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01178,728,751 - 178,769,066 (+)NCBIMhudiblu_PPA_v0panPan3
ADORA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1744,819 - 74,217 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl744,820 - 73,051 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha7100,548 - 128,787 (-)NCBI
ROS_Cfam_1.0755,302 - 84,711 (-)NCBI
UMICH_Zoey_3.1743,539 - 71,770 (-)NCBI
UNSW_CanFamBas_1.07153,116 - 181,315 (-)NCBI
UU_Cfam_GSD_1.07175,551 - 203,789 (-)NCBI
Adora1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934472,195,448 - 72,227,851 (-)NCBI
SpeTri2.0NW_0049365671,430,128 - 1,508,626 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADORA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9113,835,920 - 113,875,719 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19113,835,279 - 113,875,899 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29125,293,656 - 125,331,581 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADORA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12526,180,898 - 26,221,424 (-)NCBI
ChlSab1.1 Ensembl2526,182,446 - 26,220,776 (-)Ensembl
Adora1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248077,674,164 - 7,705,736 (-)NCBI

Position Markers
D13Hmgc03  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,689,077 - 45,689,314 (+)MAPPER
Rnor_6.01351,070,083 - 51,070,319NCBIRnor6.0
Rnor_5.01356,125,418 - 56,125,654UniSTSRnor5.0
RGSC_v3.41347,187,081 - 47,187,317UniSTSRGSC3.4
Celera1346,017,042 - 46,017,266UniSTS
Cytogenetic Map13q13UniSTS
BB176431  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,661,914 - 45,662,013 (+)MAPPER
Rnor_6.01351,042,925 - 51,043,023NCBIRnor6.0
Rnor_5.01356,098,605 - 56,098,703UniSTSRnor5.0
RGSC_v3.41347,159,719 - 47,159,817UniSTSRGSC3.4
Celera1345,989,983 - 45,990,081UniSTS
Cytogenetic Map13q13UniSTS
UniSTS:141040  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,662,660 - 45,662,839 (+)MAPPER
Rnor_6.01351,043,671 - 51,043,849NCBIRnor6.0
Rnor_5.01356,099,351 - 56,099,529UniSTSRnor5.0
RGSC_v3.41347,160,465 - 47,160,643UniSTSRGSC3.4
Celera1345,990,729 - 45,990,907UniSTS
Cytogenetic Map13q13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131409633059096330Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131409633059096330Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131444158251577031Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131981081464810814Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)132005247765052477Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132148248158537177Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132800833873008338Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132858445273584452Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132907693474076934Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132907693474076934Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133614753364868393Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133734634882346348Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133937292784372927Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133950130093652524Rat
4889861Pur29Proteinuria QTL 2913.80.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)134231074486833540Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)134231074487310744Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134357571788575717Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134567662990676629Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134877665553264877Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134905850767207219Rat
12879436Bp395Blood pressure QTL 395arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134999470851081193Rat
12879472Bp399Blood pressure QTL 399arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135060922853264877Rat


Genetic Models
This gene Adora1 is modified in the following models/strains
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir150rno-miR-150-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:223
Count of miRNA genes:139
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000004602
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 1 9 50 13
Low 3 31 42 27 10 27 8 11 14 33 25 11 8
Below cutoff 10 10 10 10 2 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004602   ⟹   ENSRNOP00000004602
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1351,042,248 - 51,076,165 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078993   ⟹   ENSRNOP00000073958
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1351,043,334 - 51,076,852 (-)Ensembl
RefSeq Acc Id: NM_017155   ⟹   NP_058851
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21345,662,488 - 45,694,801 (-)NCBI
Rnor_6.01351,043,498 - 51,075,806 (-)NCBI
Rnor_5.01356,097,883 - 56,132,155 (-)NCBI
RGSC_v3.41347,160,292 - 47,192,804 (-)RGD
Celera1345,990,556 - 46,022,753 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249859   ⟹   XP_006249921
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21345,658,872 - 45,695,821 (-)NCBI
Rnor_6.01351,042,111 - 51,076,906 (-)NCBI
Rnor_5.01356,097,883 - 56,132,155 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249861   ⟹   XP_006249923
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21345,658,872 - 45,695,821 (-)NCBI
Rnor_6.01351,042,111 - 51,076,913 (-)NCBI
Rnor_5.01356,097,883 - 56,132,155 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090617   ⟹   XP_038946545
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21345,658,872 - 45,695,595 (-)NCBI
RefSeq Acc Id: XM_039090618   ⟹   XP_038946546
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21345,658,872 - 45,695,821 (-)NCBI
RefSeq Acc Id: XM_039090619   ⟹   XP_038946547
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21345,658,872 - 45,695,596 (-)NCBI
RefSeq Acc Id: XM_039090620   ⟹   XP_038946548
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21345,658,872 - 45,695,821 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058851   ⟸   NM_017155
- UniProtKB: P25099 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006249923   ⟸   XM_006249861
- Peptide Label: isoform X1
- UniProtKB: P25099 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006249921   ⟸   XM_006249859
- Peptide Label: isoform X1
- UniProtKB: P25099 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004602   ⟸   ENSRNOT00000004602
RefSeq Acc Id: ENSRNOP00000073958   ⟸   ENSRNOT00000078993
RefSeq Acc Id: XP_038946548   ⟸   XM_039090620
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038946546   ⟸   XM_039090618
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946547   ⟸   XM_039090619
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946545   ⟸   XM_039090617
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698833
Promoter ID:EPDNEW_R9352
Type:multiple initiation site
Name:Adora1_1
Description:adenosine A1 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01351,076,239 - 51,076,299EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2048 AgrOrtholog
Ensembl Genes ENSRNOG00000003442 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000004602 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000073958 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004602 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000078993 UniProtKB/Swiss-Prot
InterPro Adeno_A1_rcpt UniProtKB/Swiss-Prot
  Adenosn_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:29290 UniProtKB/Swiss-Prot
NCBI Gene 29290 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB ADORA1 RGD
PhenoGen Adora1 PhenoGen
PRINTS ADENOSINEA1R UniProtKB/Swiss-Prot
  ADENOSINER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
TIGR TC203917
UniProt AA1R_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Adora1  adenosine A1 receptor    adenosine A1 receptor   Name updated 625702 APPROVED
2002-06-10 Adora1  adenosine A1 receptor       Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) increases urine flow and sodium excretion 628573
gene_expression expressed in the cerebellum 631744
gene_expression expressed in many regions of the brain including cortex, cerebellum, hippocampus, and thalamus 69743
gene_expression distributed along nephron and in outer medullary desceding vasa recta; localized to specific nephron segments, including glomeruli, thick ascending limb and papillary collecting duct 628573
gene_expression expressed in renal cortex and medulla 628573
gene_expression protein and mRNA expressed at high levels in the preglomerular microvessels (PGMVs) of kidney 628573
gene_function inhibits adenylyl cyclase activity 69743
gene_function antidiuretic and antinatriuretic adenosine receptor 628573
gene_process involved in the regulation of arterial pressure and heart rate 631806
gene_process plays a role in adaptation in the kidney to promote sodium excretion 628562
gene_process administration of agonists cause vasoconstriction of the preglomerular microvessels (PGMVs) and potentiation of angiotensin II-induced changes in renal vascular resistance, reduction of the glomerular filtration rate and inhibition renin release 628573
gene_process may mediate antinatriuretic effects of adenosine 628573
gene_product member of the G-protein coupled receptor family 631744
gene_protein encodes a protein sequence of 326 amino acids 631744
gene_protein 38 kDa 628351
gene_protein 39 kDa 628573
gene_regulation a high salt diet (4% NaCl for 3 weeks) decreases mRNA expression 628573
gene_transcript mRNA transcripts of 5.6 and 3.1 kb are detected 69743