RGD Reference Report - Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneously hypertensive rat complicated with hyperglycemia. - Rat Genome Database

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Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneously hypertensive rat complicated with hyperglycemia.

Authors: Ishikawa, J  Mitani, H  Bandoh, T  Kimura, M  Totsuka, T  Hayashi, S 
Citation: Ishikawa J, etal., Diabetes Res Clin Pract. 1998 Jan;39(1):3-9.
RGD ID: 1625365
Pubmed: PMID:9597368   (View Abstract at PubMed)

Metabolic and cardiovascular effects of 6-cyclohexyl-2'-O-methyl-adenosine (SDZ WAG 994), a selective and orally-active adenosine A1 receptor agonist, were examined in spontaneously hypertensive rats (SHR) with hyperglycemia (SHR-DM). This model was made by the administration of streptozotocin (STZ; 60 mg/kg s.c.) to SHR 2 days after their birth. The serum glucose concentration and systolic/mean blood pressures (MBP) in 18-22-week-old rats were 14.7 +/- 0.8 mmol/1 and 153 +/- 3/124 +/- 3 mmHg in SHR-DM, 13.7 +/- 0.3 mmol/1 and 123 +/- 3/96 +/- 4 mmHg in normotensive with STZ (WKY-DM), 10.3 +/- 0.3 mmol/1 and 165 +/- 1/136 +/- 3 mmHg in non-treated (without STZ) SHR, and 10.0 +/- 0.3 mmol/1 and 115 +/- 3/90 +/- 4 mmHg in non-treated WKY, SDZ WAG 994 at 0.1 mg/kg p.o. lowered the serum glucose concentration, blood pressure and heart rate in SHR-DM. The effects were associated with the decrease in free fatty acid (FFA), triglyceride (TG), phospholipid (PL) and total cholesterol (TC) in serum of both SHR-DM and WKY-DM. On the contrary, the hypoglycemic effect was not found in WKY-DM, although the hypotensive effect was still observed. These data suggest that the risk factors for metabolic and cardiovascular complications in diabetes are reduced by SDZ WAG 994 through activation of adenosine A1 receptors in adipocyte.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus treatmentISOAdora1 (Rattus norvegicus)1625365; 1625365associated with hypertensionRGD 
Experimental Diabetes Mellitus treatmentIDA 1625365associated with hypertensionRGD 
hypertension treatmentISOAdora1 (Rattus norvegicus)1625365; 1625365associated with diabetes mellitus and experimentalRGD 
hypertension treatmentIDA 1625365associated with diabetes mellitus and experimentalRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of systemic arterial blood pressure  IDA 1625365 RGD 
positive regulation of lipid catabolic process  IDA 1625365 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Adora1  (adenosine A1 receptor)

Genes (Mus musculus)
Adora1  (adenosine A1 receptor)

Genes (Homo sapiens)
ADORA1  (adenosine A1 receptor)


Additional Information