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Gene: DIABLO (diablo IAP-binding mitochondrial protein) Homo sapiens
Symbol: DIABLO
Name: diablo IAP-binding mitochondrial protein
Description: Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; intrinsic apoptotic signaling pathway in response to oxidative stress; and neuron apoptotic process. Localizes to the mitochondrion. Implicated in autosomal dominant nonsyndromic deafness 64. Biomarker of lung non-small cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 0610041G12Rik; DFNA64; diablo homolog, mitochondrial; diablo, mitochondrial; DIABLO-S; direct IAP-binding protein with low pI; FLJ10537; FLJ25049; mitochondrial Smac protein; second mitochondria-derived activator of caspase; SMAC; SMAC3
Mus musculus (house mouse) : Diablo (diablo, IAP-binding mitochondrial protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Diablo (diablo, IAP-binding mitochondrial protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Diablo (diablo IAP-binding mitochondrial protein)
Pan paniscus (bonobo/pygmy chimpanzee) : DIABLO (diablo IAP-binding mitochondrial protein)
Canis lupus familiaris (dog) : DIABLO (diablo IAP-binding mitochondrial protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Diablo (diablo IAP-binding mitochondrial protein)
Sus scrofa (pig) : DIABLO (diablo IAP-binding mitochondrial protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3812122,207,662 - 122,227,456 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712122,692,209 - 122,712,081 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612121,258,162 - 121,276,552 (-)NCBINCBI36hg18NCBI36
Celera12122,281,555 - 122,301,434 (-)NCBI
Cytogenetic Map12q24.31NCBI
HuRef12119,653,145 - 119,672,846 (-)NCBIHuRef
CHM1_112122,660,505 - 122,680,373 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DIABLO
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1322043
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.