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Gene: Kcnj11 (potassium inwardly-rectifying channel, subfamily J, member 11) Rattus norvegicus
Symbol: Kcnj11
Name: potassium inwardly-rectifying channel, subfamily J, member 11
RGD ID: 69247
Description: Exhibits several functions, including ankyrin binding activity; inorganic cation transmembrane transporter activity; and protein C-terminus binding activity. Involved in several processes, including cation transport; cellular response to nicotine; and response to ischemia. Localizes to several cellular components, including axolemma; cell body fiber; and cytoplasmic vesicle. Biomarker of diabetes mellitus (multiple); epilepsy (multiple); hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 2 and glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATP-sensitive inward rectifier potassium channel 11; BIR; inward rectifier K(+) channel Kir6.2; Kir6.2; potassium channel, inwardly rectifying subfamily J member 11; potassium channel, inwardly rectifying subfamily J, member 11; potassium inwardly rectifying channel, subfamily J, member 11; potassium inwardly-rectifying channel subfamily J member 11; potassium voltage-gated channel subfamily J member 11
Allele / Splice: Kcnj11em5Mcwi   Kcnj11em9Mcwi  
Genetic Models: SS-Kcnj11em5Mcwi SS-Kcnj11em9Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01102,103,093 - 102,107,134 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,103,094 - 102,106,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,186,859 - 103,190,535 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,614,960 - 96,617,993 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,693,070 - 96,696,104 (-)NCBI
Celera190,842,071 - 90,845,104 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Kcnj11
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69247
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.