potassium inwardly-rectifying channel, subfamily J, member 11
RGD ID:
69247
Description:
Enables several functions, including ankyrin binding activity; inorganic cation transmembrane transporter activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to nicotine; potassium ion import across plasma membrane; and response to ischemia. Located in several cellular components, including axolemma; cell body fiber; and cytoplasmic vesicle. Part of inward rectifying potassium channel. Biomarker of brain disease (multiple); glucose metabolism disease (multiple); hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 2 and glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
polymorphisms in the human gene are linked to altered insulin secretion, E23K polymorphism appears to confer susceptibility to diabetes type-2 in Caucasian population
[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein], Glyburide inhibits the reaction [[Oligomycins co-treated with Deoxyglucose] results in increased activity of [KCNJ11 protein binds to ABCC9 protein]]
Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]], Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]]
Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]] more ...
Creatine metabolite inhibits the reaction [Adenosine Monophosphate inhibits the reaction [Adenosine Triphosphate results in decreased activity of [KCNJ11 protein binds to ABCC9 protein]]]
[3-bromo-2-oxopropionic acid co-treated with Rotenone] results in increased expression of KCNJ11 mRNA, [3-bromo-2-oxopropionic acid co-treated with Rotenone] results in increased expression of KCNJ11 protein
[KCNJ11 protein binds to ABCC8 protein] which results in increased export of Rubidium, [KCNJ11 protein binds to ABCC9 protein] which results in increased export of Rubidium
[KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide, Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein]
polymorphisms in the human gene are linked to altered insulin secretion, E23K polymorphism appears to confer susceptibility to diabetes type-2 in Caucasian population
polymorphisms in the human gene are linked to altered insulin secretion, E23K polymorphism appears to confer susceptibility to diabetes type-2 in Caucasian population