Gene: Kcnj11 (potassium voltage-gated channel subfamily J member 11) Rattus norvegicus
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Symbol: Kcnj11
Name: potassium voltage-gated channel subfamily J member 11
Description: ENCODES a protein that exhibits ankyrin binding; ATP-activated inward rectifier potassium channel activity; heat shock protein binding; INVOLVED IN cellular response to glucose stimulus; cellular response to nicotine; cellular response to tumor necrosis factor; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; ASSOCIATED WITH Diabetes Mellitus, Experimental ; hypertension; Kidney Reperfusion Injury; FOUND IN acrosomal vesicle; axolemma; cell body fiber; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide
AGR Description: Exhibits several functions, including ATP-activated inward rectifier potassium channel activity, ankyrin binding activity, and heat shock protein binding activity; involved in several processes, including cellular response to glucose stimulus, cellular response to nicotine, and cellular response to tumor necrosis factor; localizes to several cellular components, including the T-tubule, cytoplasm, and neuron projection; biomarker of several diseases, including diabetes mellitus (multiple), epilepsy (multiple), hypertension, and sciatic neuropathy; orthologous to human KCNJ11 (potassium voltage-gated channel subfamily J member 11).
Merged Description: Exhibits several functions, including ATP-activated inward rectifier potassium channel activity, ankyrin binding activity, and heat shock protein binding activity; involved in several processes, including cellular response to glucose stimulus, cellular response to nicotine, and cellular response to tumor necrosis factor; localizes to several cellular components, including the T-tubule, cytoplasm, and neuron projection; biomarker of several diseases, including diabetes mellitus (multiple), epilepsy (multiple), hypertension, and sciatic neuropathy; orthologous to human KCNJ11 (potassium voltage-gated channel subfamily J member 11); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATP-sensitive inward rectifier potassium channel 11; BIR; inward rectifier K(+) channel Kir6.2; Kir6.2; potassium channel, inwardly rectifying subfamily J member 11; potassium channel, inwardly rectifying subfamily J, member 11; potassium inwardly rectifying channel, subfamily J, member 11; potassium inwardly-rectifying channel subfamily J member 11
Orthologs:
Allele / Splice: Kcnj11em5Mcwi   Kcnj11em9Mcwi  
Genetic Models: SS-Kcnj11em5Mcwi SS-Kcnj11em9Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01102,103,093 - 102,107,134 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01103,186,859 - 103,190,535 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,614,960 - 96,617,993 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,693,070 - 96,696,104 (-)NCBI
Celera190,842,071 - 90,845,104 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Kcnj11
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69247
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.