Gene: Kcnj11 (potassium voltage-gated channel subfamily J member 11) Rattus norvegicus
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Symbol: Kcnj11
Name: potassium voltage-gated channel subfamily J member 11
Description: ENCODES a protein that exhibits ankyrin binding; ATP-activated inward rectifier potassium channel activity; heat shock protein binding; INVOLVED IN cellular response to glucose stimulus; cellular response to nicotine; cellular response to tumor necrosis factor; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; ASSOCIATED WITH Diabetes Mellitus, Experimental ; hypertension; Kidney Reperfusion Injury; FOUND IN acrosomal vesicle; axolemma; cell body fiber; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide
AGR Description: Exhibits several functions, including ATP-activated inward rectifier potassium channel activity, ankyrin binding activity, and heat shock protein binding activity; involved in several processes, including cellular response to glucose stimulus, cellular response to nicotine, and cellular response to tumor necrosis factor; localizes to several cellular components, including the T-tubule, cytoplasm, and neuron projection; biomarker of several diseases, including diabetes mellitus (multiple), epilepsy (multiple), hypertension, and sciatic neuropathy; orthologous to human KCNJ11 (potassium voltage-gated channel subfamily J member 11).
Merged Description: Exhibits several functions, including ATP-activated inward rectifier potassium channel activity, ankyrin binding activity, and heat shock protein binding activity; involved in several processes, including cellular response to glucose stimulus, cellular response to nicotine, and cellular response to tumor necrosis factor; localizes to several cellular components, including the T-tubule, cytoplasm, and neuron projection; biomarker of several diseases, including diabetes mellitus (multiple), epilepsy (multiple), hypertension, and sciatic neuropathy; orthologous to human KCNJ11 (potassium voltage-gated channel subfamily J member 11); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATP-sensitive inward rectifier potassium channel 11; BIR; inward rectifier K(+) channel Kir6.2; Kir6.2; potassium channel, inwardly rectifying subfamily J member 11; potassium channel, inwardly rectifying subfamily J, member 11; potassium inwardly rectifying channel, subfamily J, member 11; potassium inwardly-rectifying channel subfamily J member 11
Orthologs:
Homo sapiens (human) : KCNJ11 (potassium voltage-gated channel subfamily J member 11)  HGNC  Alliance
Mus musculus (house mouse) : Kcnj11 (potassium inwardly rectifying channel, subfamily J, member 11)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kcnj11 (potassium voltage-gated channel subfamily J member 11)
Pan paniscus (bonobo/pygmy chimpanzee) : KCNJ11 (potassium voltage-gated channel subfamily J member 11)
Canis lupus familiaris (dog) : KCNJ11 (potassium voltage-gated channel subfamily J member 11)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kcnj11 (potassium voltage-gated channel subfamily J member 11)
Sus scrofa (pig) : KCNJ11 (potassium voltage-gated channel subfamily J member 11)
more info ...
Allele / Splice: Kcnj11em5Mcwi   Kcnj11em9Mcwi  
Genetic Models: SS-Kcnj11em5Mcwi SS-Kcnj11em9Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01102,103,093 - 102,107,134 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01103,186,859 - 103,190,535 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,614,960 - 96,617,993 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,693,070 - 96,696,104 (-)NCBI
Celera190,842,071 - 90,845,104 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

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Genomics

Comparative Map Data
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QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

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Nomenclature History
RGD Curation Notes
  
More on Kcnj11
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69247
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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