Kcnj11 (potassium inwardly-rectifying channel, subfamily J, member 11) - Rat Genome Database

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Gene: Kcnj11 (potassium inwardly-rectifying channel, subfamily J, member 11) Rattus norvegicus
Analyze
Symbol: Kcnj11
Name: potassium inwardly-rectifying channel, subfamily J, member 11
RGD ID: 69247
Description: Enables several functions, including ankyrin binding activity; monoatomic cation transmembrane transporter activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to nicotine; potassium ion import across plasma membrane; and response to ischemia. Located in several cellular components, including axolemma; cell body fiber; and cytoplasmic vesicle. Part of inward rectifying potassium channel. Is active in glutamatergic synapse and presynaptic membrane. Biomarker of brain disease (multiple); glucose metabolism disease (multiple); hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP-sensitive inward rectifier potassium channel 11; BIR; inward rectifier K(+) channel Kir6.2; Kir6.2; potassium channel, inwardly rectifying subfamily J member 11; potassium channel, inwardly rectifying subfamily J, member 11; potassium inwardly rectifying channel, subfamily J, member 11; potassium inwardly-rectifying channel subfamily J member 11; potassium voltage-gated channel subfamily J member 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Kcnj11em5Mcwi   Kcnj11em9Mcwi  
Genetic Models: SS-Kcnj11em5Mcwi SS-Kcnj11em9Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,591,048 - 96,594,574 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,591,049 - 96,594,082 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,977,177 - 101,980,211 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01110,449,162 - 110,452,195 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01103,739,531 - 103,742,564 (-)NCBIRnor_WKY
Rnor_6.01102,103,093 - 102,107,134 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,103,094 - 102,106,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,186,859 - 103,190,535 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,614,960 - 96,617,993 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,693,070 - 96,696,104 (-)NCBI
Celera190,842,071 - 90,845,104 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
altered insulin secretion pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
forkhead class A signaling pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
insulin secretion pathway  (TAS)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
type 2 diabetes mellitus pathway  (IEA,ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. A syndrome of congenital hyperinsulinism and rhabdomyolysis is caused by KCNJ11 mutation. Albaqumi M, etal., J Med Genet. 2014 Apr;51(4):271-4. doi: 10.1136/jmedgenet-2013-102085. Epub 2014 Jan 13.
2. Endosomal KATP channels as a reservoir after myocardial ischemia: a role for SUR2 subunits. Bao L, etal., Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H262-70. doi: 10.1152/ajpheart.00857.2010. Epub 2010 Oct 22.
3. Identification of two novel frameshift mutations in the KCNJ11 gene in two Italian patients affected by Congenital Hyperinsulinism of Infancy. Biagiotti L, etal., Exp Mol Pathol. 2007 Aug;83(1):59-64. Epub 2007 Jan 17.
4. KATP channel conductance of descending vasa recta pericytes. Cao C, etal., Am J Physiol Renal Physiol. 2005 Dec;289(6):F1235-45. Epub 2005 Jul 26.
5. Molecular basis of ATP-sensitive K+ channels in rat vascular smooth muscles. Cao K, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):463-9.
6. Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel. Cooper PE, etal., J Biol Chem. 2017 Oct 20;292(42):17387-17398. doi: 10.1074/jbc.M117.804971. Epub 2017 Aug 23.
7. An in-frame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1. Craig TJ, etal., J Clin Endocrinol Metab. 2009 Jul;94(7):2551-7. Epub 2009 Apr 7.
8. Subunit composition of ATP-sensitive potassium channels in mitochondria of rat hearts. Cuong DV, etal., Mitochondrion. 2005 Apr;5(2):121-33.
9. The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function. Dhar-Chowdhury P, etal., J Biol Chem. 2005 Nov 18;280(46):38464-70. Epub 2005 Sep 16.
10. Congenital hyperinsulinism: clinical and molecular analysis of a large Italian cohort. Faletra F, etal., Gene. 2013 May 25;521(1):160-5. doi: 10.1016/j.gene.2013.03.021. Epub 2013 Mar 16.
11. Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program. Florez JC, etal., Diabetes. 2007 Feb;56(2):531-6.
12. Effects of a sucrose-enriched diet on the pattern of gene expression, contraction and Ca(2+) transport in Goto-Kakizaki type 2 diabetic rat heart. Gaber EM, etal., Exp Physiol. 2014 Jun;99(6):881-93. doi: 10.1113/expphysiol.2013.077594. Epub 2014 Mar 28.
13. Iptakalim, opener of K(ATP), reverses the enhanced expression of genes encoding K(ATP) subunits in spontaneously hypertensive rats. Gao M, etal., Life Sci. 2005 Oct 14;77(22):2743-51.
14. Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes. Garg V, etal., Cardiovasc Res. 2009 Apr 1;82(1):51-8. doi: 10.1093/cvr/cvp039. Epub 2009 Jan 30.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. Girard CA, etal., J Clin Invest. 2009 Jan;119(1):80-90. doi: 10.1172/JCI35772. Epub 2008 Dec 8.
17. KCNJ11 activating mutations are associated with developmental delay, epilepsy and neonatal diabetes syndrome and other neurological features. Gloyn AL, etal., Eur J Hum Genet. 2006 Jul;14(7):824-30. Epub 2006 May 3.
18. Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism. Gloyn AL, etal., Hum Mutat. 2006 Mar;27(3):220-31.
19. Permanent neonatal diabetes due to paternal germline mosaicism for an activating mutation of the KCNJ11 Gene encoding the Kir6.2 subunit of the beta-cell potassium adenosine triphosphate channel. Gloyn AL, etal., J Clin Endocrinol Metab. 2004 Aug;89(8):3932-5.
20. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. Gloyn AL, etal., N Engl J Med. 2004 Apr 29;350(18):1838-49.
21. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
22. Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats. Gyte A, etal., J Neuroendocrinol. 2007 Dec;19(12):941-51.
23. Channel regulation of glucose sensing in the pancreatic beta-cell. Hiriart M and Aguilar-Bryan L, Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1298-306. Epub 2008 Oct 21.
24. Heterogeneity of ATP-sensitive K+ channels in cardiac myocytes: enrichment at the intercalated disk. Hong M, etal., J Biol Chem. 2012 Nov 30;287(49):41258-67. doi: 10.1074/jbc.M112.412122. Epub 2012 Oct 12.
25. Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload. Hu X, etal., Circ Res. 2008 Oct 24;103(9):1009-17. doi: 10.1161/CIRCRESAHA.107.170795. Epub 2008 Sep 18.
26. Pregabalin attenuates excitotoxicity in diabetes. Huang CW, etal., PLoS One. 2013 Jun 13;8(6):e65154. doi: 10.1371/journal.pone.0065154. Print 2013.
27. A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels. Inagaki N, etal., Neuron. 1996 May;16(5):1011-7.
28. Angiotensin II and tumour necrosis factor alpha as mediators of ATP-dependent potassium channel remodelling in post-infarction heart failure. Isidoro Tavares N, etal., Cardiovasc Res. 2009 Sep 1;83(4):726-36. doi: 10.1093/cvr/cvp162. Epub 2009 May 21.
29. The pattern of ATP-sensitive K+ channel subunits, Kir6.2 and SUR1 mRNA expressions in DG region is different from those in CA1-3 regions of chronic epilepsy induced by picrotoxin in rats. Jiang K, etal., Neuropathology. 2007 Dec;27(6):531-8.
30. Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation. Kline CF, etal., Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16669-74. doi: 10.1073/pnas.0907138106. Epub 2009 Sep 15.
31. Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cells. Lim A, etal., Diabetes. 2009 Dec;58(12):2813-9. doi: 10.2337/db09-0600. Epub 2009 Aug 31.
32. Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge. Lodwick D, etal., Biochem J. 2014 Dec 15;464(3):343-54. doi: 10.1042/BJ20140273.
33. Detection of K(ATP) channels subunits in human term placental explants and evaluation of their implication in human placental lactogen (hPL) and human chorionic gonadotropin (hCG) release. Lybaert P, etal., Placenta. 2013 Jun;34(6):467-73. doi: 10.1016/j.placenta.2013.03.006. Epub 2013 Apr 13.
34. Severe congenital hyperinsulinism caused by a mutation in the Kir6.2 subunit of the adenosine triphosphate-sensitive potassium channel impairing trafficking and function. Marthinet E, etal., J Clin Endocrinol Metab. 2005 Sep;90(9):5401-6. Epub 2005 Jul 5.
35. A role for ATP-sensitive potassium channels in male sexual behavior. McDevitt MA, etal., Horm Behav. 2009 Feb;55(2):366-74. Epub 2008 Sep 16.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. Clinical and genetic evaluation of patients with KATP channel mutations from the German registry for congenital hyperinsulinism. Mohnike K, etal., Horm Res Paediatr. 2014;81(3):156-68. doi: 10.1159/000356905. Epub 2014 Jan 7.
38. Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells. Moritz W, etal., Endocrinology 2001 Jan;142(1):129-38.
39. Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. Morrissey A, etal., BMC Physiol. 2005 Jan 12;5(1):1.
40. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
41. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
44. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
45. Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels. Rainbow RD, etal., Biochem J. 2004 Apr 1;379(Pt 1):173-81.
46. GOA pipeline RGD automated data pipeline
47. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
48. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
49. Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes. Riedel MJ, etal., Hum Genet. 2005 Feb;116(3):133-45. Epub 2004 Nov 23.
50. Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy. Ruiz N, etal., Brain Res. 2011 Dec 2;1426:86-95. Epub 2011 Oct 8.
51. Chronic nicotine induces hypoxia inducible factor-2alpha in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2. Salman S, etal., Am J Physiol Cell Physiol. 2012 May 15;302(10):C1531-8. doi: 10.1152/ajpcell.00052.2012. Epub 2012 Mar 7.
52. Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney. Shimizu S, etal., Br J Pharmacol. 2011 May;163(2):272-82. doi: 10.1111/j.1476-5381.2011.01231.x.
53. Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes. Singh H, etal., J Mol Cell Cardiol. 2003 May;35(5):445-59.
54. Genetic analysis of Italian patients with congenital hyperinsulinism of infancy. Sogno Valin P, etal., Horm Res Paediatr. 2013;79(4):236-42. doi: 10.1159/000350827. Epub 2013 May 1.
55. Expression of functional Kir6.1 channels regulates glutamate release at CA3 synapses in generation of epileptic form of seizures. Soundarapandian MM, etal., J Neurochem. 2007 Dec;103(5):1982-8. doi: 10.1111/j.1471-4159.2007.04883.x. Epub 2007 Sep 18.
56. Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes with Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5 327 Non-diabetic Finnish Men. Stancakova A, etal., Diabetes. 2009 Jun 5.
57. Role for SUR2A in coupling cardiac K(ATP) channels to caveolin-3. Sun W and Hu K, Cell Physiol Biochem. 2010;25(4-5):409-18. doi: 10.1159/000303045. Epub 2010 Mar 23.
58. Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release. Tagmose TM, etal., J Med Chem. 2004 Jun 3;47(12):3202-11.
59. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
60. Rat inwardly rectifying potassium channel Kir6.2: cloning electrophysiological characterization, and decreased expression in pancreatic islets of male Zucker diabetic fatty rats. Tokuyama Y, etal., Biochem Biophys Res Commun 1996 Mar 27;220(3):532-8.
61. The A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel. Wan TC, etal., J Pharmacol Exp Ther. 2008 Jan;324(1):234-43. Epub 2007 Sep 28.
62. Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson's disease: implications for treating Parkinson's disease? Wang S, etal., Neuropharmacology. 2005 Jun;48(7):984-92.
63. Effect of electronic stimulation at Neiguan (PC 6) acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia. Wang W, etal., J Tradit Chin Med. 2015 Oct;35(5):577-82.
64. Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes. Wu SN, etal., Life Sci. 2007 Jan 2;80(4):378-87. Epub 2006 Oct 17.
65. Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complex. Yan FF, etal., Mol Biol Cell. 2010 Jun 15;21(12):1945-54. Epub 2010 Apr 28.
66. Alterations in the expression of ATP-sensitive potassium channel subunit mRNA after acute peripheral nerve and spinal cord injury. Yin XF, etal., Eur Neurol. 2007;57(1):4-10. Epub 2006 Nov 14.
67. Neuroprotective effects of 17beta-estradiol associate with KATP in rat brain. Zhang D, etal., Neuroreport. 2012 Nov 14;23(16):952-7. doi: 10.1097/WNR.0b013e3283598de6.
68. The E23K variation in the KCNJ11 gene is associated with type 2 diabetes in Chinese and East Asian population. Zhou D, etal., J Hum Genet. 2009 Jun 5.
69. Different localization of ATP sensitive K+ channel subunits in rat testis. Zhou M, etal., Anat Rec (Hoboken). 2011 Apr;294(4):729-37. doi: 10.1002/ar.21348. Epub 2011 Feb 15.
70. Localization of pore-forming subunit of the ATP-sensitive K(+)-channel, Kir6.2, in rat brain neurons and glial cells. Zhou M, etal., Brain Res Mol Brain Res 2002 May 30;101(1-2):23-32.
71. ATP-sensitive K+-channel subunits on the mitochondria and endoplasmic reticulum of rat cardiomyocytes. Zhou M, etal., J Histochem Cytochem. 2005 Dec;53(12):1491-500. Epub 2005 Jun 27.
72. Engineered Kir6.2 mutations that correct the trafficking defect of K(ATP) channels caused by specific SUR1 mutations. Zhou Q, etal., Channels (Austin). 2013 Jul-Aug;7(4):313-7. Epub 2013 May 21.
73. KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy. Zoga V, etal., Mol Pain. 2010 Jan 26;6:6. doi: 10.1186/1744-8069-6-6.
Additional References at PubMed
PMID:8798681   PMID:8889548   PMID:8923010   PMID:12860923   PMID:14592811   PMID:15044189   PMID:15166124   PMID:15528203   PMID:15583126   PMID:15613469   PMID:15739238   PMID:15775962  
PMID:15784703   PMID:16085792   PMID:16537788   PMID:16731837   PMID:16956886   PMID:17311891   PMID:18006464   PMID:18073297   PMID:18250167   PMID:18776135   PMID:19141293   PMID:19151370  
PMID:19464385   PMID:19933268   PMID:20008464   PMID:20456845   PMID:20610380   PMID:21145327   PMID:21193530   PMID:21321069   PMID:21474909   PMID:21482559   PMID:21654216   PMID:22144717  
PMID:22257425   PMID:22480512   PMID:22636679   PMID:22802363   PMID:23219002   PMID:23418587   PMID:23700433   PMID:24014680   PMID:24429282   PMID:24480471   PMID:25073062   PMID:27430376  
PMID:28082085   PMID:28092267   PMID:30074836   PMID:30868916  


Genomics

Comparative Map Data
Kcnj11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,591,048 - 96,594,574 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,591,049 - 96,594,082 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,977,177 - 101,980,211 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01110,449,162 - 110,452,195 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01103,739,531 - 103,742,564 (-)NCBIRnor_WKY
Rnor_6.01102,103,093 - 102,107,134 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,103,094 - 102,106,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,186,859 - 103,190,535 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,614,960 - 96,617,993 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,693,070 - 96,696,104 (-)NCBI
Celera190,842,071 - 90,845,104 (-)NCBICelera
Cytogenetic Map1q22NCBI
KCNJ11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,385,248 - 17,389,346 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1117,365,172 - 17,389,331 (-)EnsemblGRCh38hg38GRCh38
GRCh371117,406,795 - 17,410,893 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,363,371 - 17,366,782 (-)NCBINCBI36Build 36hg18NCBI36
Build 341117,364,788 - 17,366,737NCBI
Celera1117,536,622 - 17,540,705 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,090,617 - 17,094,700 (-)NCBIHuRef
CHM1_11117,406,598 - 17,410,681 (-)NCBICHM1_1
T2T-CHM13v2.01117,482,848 - 17,486,946 (-)NCBIT2T-CHM13v2.0
Kcnj11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,746,545 - 45,750,215 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,743,377 - 45,750,188 (-)EnsemblGRCm39 Ensembl
GRCm38746,097,123 - 46,100,952 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,093,953 - 46,100,764 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,352,532 - 53,355,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,965,204 - 45,968,279 (-)NCBIMGSCv36mm8
Celera741,570,483 - 41,573,555 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.66NCBI
Kcnj11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,210,545 - 32,211,717 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541432,209,426 - 32,212,424 (-)NCBIChiLan1.0ChiLan1.0
KCNJ11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11119,679,358 - 19,683,468 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,440,522 - 17,444,075 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,125,885 - 17,129,579 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,127,557 - 17,128,729 (-)Ensemblpanpan1.1panPan2
KCNJ11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12139,953,461 - 39,957,615 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2139,955,551 - 39,956,723 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2139,454,228 - 39,457,833 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02141,059,361 - 41,062,966 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,060,903 - 41,062,075 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,072,057 - 40,075,662 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,279,502 - 40,283,108 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,618,209 - 40,621,814 (-)NCBIUU_Cfam_GSD_1.0
Kcnj11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,651,254 - 45,654,240 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,685,924 - 1,687,096 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365281,685,015 - 1,688,220 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,757,356 - 41,765,555 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1241,756,637 - 41,760,340 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,815,173 - 44,817,370 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1147,582,519 - 47,586,466 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,583,629 - 47,584,801 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038145,013,121 - 145,016,726 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,013,225 - 9,014,397 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247669,012,166 - 9,015,269 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnj11
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:100
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000028685
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat

Markers in Region
PMC312732P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,592,815 - 96,593,315 (+)MAPPERmRatBN7.2
Rnor_6.01102,104,861 - 102,105,360NCBIRnor6.0
Rnor_5.01103,188,626 - 103,189,125UniSTSRnor5.0
RGSC_v3.4196,616,727 - 96,617,226UniSTSRGSC3.4
Celera190,843,838 - 90,844,337UniSTS
Cytogenetic Map1q22UniSTS
RH130776  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,591,617 - 96,591,832 (+)MAPPERmRatBN7.2
Rnor_6.01102,103,663 - 102,103,877NCBIRnor6.0
Rnor_5.01103,187,428 - 103,187,642UniSTSRnor5.0
RGSC_v3.4196,615,529 - 96,615,743UniSTSRGSC3.4
Celera190,842,640 - 90,842,854UniSTS
RH 3.4 Map1909.4UniSTS
Cytogenetic Map1q22UniSTS
BE113377  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,591,122 - 96,591,288 (+)MAPPERmRatBN7.2
Rnor_6.01102,103,168 - 102,103,333NCBIRnor6.0
Rnor_5.01103,186,933 - 103,187,098UniSTSRnor5.0
RGSC_v3.4196,615,034 - 96,615,199UniSTSRGSC3.4
Celera190,842,145 - 90,842,310UniSTS
RH 3.4 Map1908.9UniSTS
Cytogenetic Map1q22UniSTS


Genetic Models
This gene Kcnj11 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 33 8 11 15 8
Low 2 10 14 2 5 2 59 23 30 8
Below cutoff 1 25 21 14 21 12 11 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB043638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC120807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW527189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF565039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D61687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U44897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000028685   ⟹   ENSRNOP00000028685
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,591,049 - 96,594,082 (-)Ensembl
Rnor_6.0 Ensembl1102,103,094 - 102,106,127 (-)Ensembl
RefSeq Acc Id: NM_031358   ⟹   NP_112648
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,591,049 - 96,594,082 (-)NCBI
Rnor_6.01102,103,094 - 102,106,127 (-)NCBI
Rnor_5.01103,186,859 - 103,190,535 (-)NCBI
RGSC_v3.4196,614,960 - 96,617,993 (-)RGD
Celera190,842,071 - 90,845,104 (-)RGD
Sequence:
RefSeq Acc Id: XM_008759421   ⟹   XP_008757643
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,591,048 - 96,594,574 (-)NCBI
Rnor_6.01102,103,093 - 102,107,134 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589780   ⟹   XP_017445269
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,591,048 - 96,594,572 (-)NCBI
Rnor_6.01102,103,093 - 102,106,883 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589782   ⟹   XP_017445271
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,591,049 - 96,594,503 (-)NCBI
Rnor_6.01102,103,093 - 102,106,539 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092510   ⟹   XP_038948438
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,591,048 - 96,594,542 (-)NCBI
RefSeq Acc Id: XM_039092515   ⟹   XP_038948443
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,591,049 - 96,594,503 (-)NCBI
RefSeq Acc Id: XM_039092522   ⟹   XP_038948450
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,591,049 - 96,594,503 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_112648   ⟸   NM_031358
- UniProtKB: Q9JM48 (UniProtKB/Swiss-Prot),   P70673 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008757643   ⟸   XM_008759421
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017445269   ⟸   XM_017589780
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017445271   ⟸   XM_017589782
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000028685   ⟸   ENSRNOT00000028685
RefSeq Acc Id: XP_038948438   ⟸   XM_039092510
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038948450   ⟸   XM_039092522
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038948443   ⟸   XM_039092515
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70673-F1-model_v2 AlphaFold P70673 1-390 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69247 AgrOrtholog
BioCyc Gene G2FUF-59633 BioCyc
Ensembl Genes ENSRNOG00000021128 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000028685 ENTREZGENE
  ENSRNOP00000028685.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028685 ENTREZGENE
  ENSRNOT00000028685.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  2.60.40.1400 UniProtKB/Swiss-Prot
InterPro Ig_E-set UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir6.2 UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot
  Kir_TM UniProtKB/Swiss-Prot
KEGG Report rno:83535 UniProtKB/Swiss-Prot
NCBI Gene 83535 ENTREZGENE
PANTHER PTHR11767 UniProtKB/Swiss-Prot
  PTHR11767:SF44 UniProtKB/Swiss-Prot
Pfam IRK UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
PharmGKB KCNJ11 RGD
PhenoGen Kcnj11 PhenoGen
PIRSF GIRK_kir UniProtKB/Swiss-Prot
PRINTS KIR62CHANNEL UniProtKB/Swiss-Prot
  KIRCHANNEL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
TIGR TC216683
UniProt KCJ11_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9JM48 ENTREZGENE
UniProt Secondary Q62906 UniProtKB/Swiss-Prot
  Q9JM48 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Kcnj11  potassium inwardly rectifying channel, subfamily J, member 11      Symbol and Name status set to approved 1299863 APPROVED
2002-07-25 Kir6.2  potassium inwardly rectifying channel, subfamily J, member 11      gene retired, merged with Kcnj11 (RGD:69247) 61033 WITHDRAWN
2002-06-10 Kcnj11  potassium inwardly rectifying channel, subfamily J, member 11      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in vascular smooth muscle cells 724755