Kcnj11 (potassium inwardly-rectifying channel, subfamily J, member 11) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Kcnj11 (potassium inwardly-rectifying channel, subfamily J, member 11) Rattus norvegicus
Analyze
Symbol: Kcnj11
Name: potassium inwardly-rectifying channel, subfamily J, member 11
RGD ID: 69247
Description: Exhibits several functions, including ankyrin binding activity; inorganic cation transmembrane transporter activity; and protein C-terminus binding activity. Involved in several processes, including cation transport; cellular response to nicotine; and response to ischemia. Localizes to several cellular components, including axolemma; cell body fiber; and cytoplasmic vesicle. Biomarker of epilepsy (multiple); glucose metabolism disease (multiple); hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 2 and glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATP-sensitive inward rectifier potassium channel 11; BIR; inward rectifier K(+) channel Kir6.2; Kir6.2; potassium channel, inwardly rectifying subfamily J member 11; potassium channel, inwardly rectifying subfamily J, member 11; potassium inwardly rectifying channel, subfamily J, member 11; potassium inwardly-rectifying channel subfamily J member 11; potassium voltage-gated channel subfamily J member 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Kcnj11em5Mcwi   Kcnj11em9Mcwi  
Genetic Models: SS-Kcnj11em5Mcwi SS-Kcnj11em9Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,591,048 - 96,594,574 (-)NCBI
Rnor_6.0 Ensembl1102,103,094 - 102,106,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01102,103,093 - 102,107,134 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01103,186,859 - 103,190,535 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,614,960 - 96,617,993 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,693,070 - 96,696,104 (-)NCBI
Celera190,842,071 - 90,845,104 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
altered insulin secretion pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
forkhead class A signaling pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
insulin secretion pathway  (TAS)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
type 2 diabetes mellitus pathway  (IEA,ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
1. Albaqumi M, etal., J Med Genet. 2014 Apr;51(4):271-4. doi: 10.1136/jmedgenet-2013-102085. Epub 2014 Jan 13.
2. Bao L, etal., Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H262-70. doi: 10.1152/ajpheart.00857.2010. Epub 2010 Oct 22.
3. Biagiotti L, etal., Exp Mol Pathol. 2007 Aug;83(1):59-64. Epub 2007 Jan 17.
4. Cao C, etal., Am J Physiol Renal Physiol. 2005 Dec;289(6):F1235-45. Epub 2005 Jul 26.
5. Cao K, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):463-9.
6. Cooper PE, etal., J Biol Chem. 2017 Oct 20;292(42):17387-17398. doi: 10.1074/jbc.M117.804971. Epub 2017 Aug 23.
7. Craig TJ, etal., J Clin Endocrinol Metab. 2009 Jul;94(7):2551-7. Epub 2009 Apr 7.
8. Cuong DV, etal., Mitochondrion. 2005 Apr;5(2):121-33.
9. Dhar-Chowdhury P, etal., J Biol Chem. 2005 Nov 18;280(46):38464-70. Epub 2005 Sep 16.
10. Faletra F, etal., Gene. 2013 May 25;521(1):160-5. doi: 10.1016/j.gene.2013.03.021. Epub 2013 Mar 16.
11. Florez JC, etal., Diabetes. 2007 Feb;56(2):531-6.
12. Gaber EM, etal., Exp Physiol. 2014 Jun;99(6):881-93. doi: 10.1113/expphysiol.2013.077594. Epub 2014 Mar 28.
13. Gao M, etal., Life Sci. 2005 Oct 14;77(22):2743-51.
14. Garg V, etal., Cardiovasc Res. 2009 Apr 1;82(1):51-8. doi: 10.1093/cvr/cvp039. Epub 2009 Jan 30.
15. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Girard CA, etal., J Clin Invest. 2009 Jan;119(1):80-90. doi: 10.1172/JCI35772. Epub 2008 Dec 8.
17. Gloyn AL, etal., Eur J Hum Genet. 2006 Jul;14(7):824-30. Epub 2006 May 3.
18. Gloyn AL, etal., Hum Mutat. 2006 Mar;27(3):220-31.
19. Gloyn AL, etal., J Clin Endocrinol Metab. 2004 Aug;89(8):3932-5.
20. Gloyn AL, etal., N Engl J Med. 2004 Apr 29;350(18):1838-49.
21. GOA data from the GO Consortium
22. Gyte A, etal., J Neuroendocrinol. 2007 Dec;19(12):941-51.
23. Hiriart M and Aguilar-Bryan L, Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1298-306. Epub 2008 Oct 21.
24. Hong M, etal., J Biol Chem. 2012 Nov 30;287(49):41258-67. doi: 10.1074/jbc.M112.412122. Epub 2012 Oct 12.
25. Hu X, etal., Circ Res. 2008 Oct 24;103(9):1009-17. doi: 10.1161/CIRCRESAHA.107.170795. Epub 2008 Sep 18.
26. Huang CW, etal., PLoS One. 2013 Jun 13;8(6):e65154. doi: 10.1371/journal.pone.0065154. Print 2013.
27. Isidoro Tavares N, etal., Cardiovasc Res. 2009 Sep 1;83(4):726-36. doi: 10.1093/cvr/cvp162. Epub 2009 May 21.
28. Jiang K, etal., Neuropathology. 2007 Dec;27(6):531-8.
29. Kline CF, etal., Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16669-74. doi: 10.1073/pnas.0907138106. Epub 2009 Sep 15.
30. Lim A, etal., Diabetes. 2009 Dec;58(12):2813-9. doi: 10.2337/db09-0600. Epub 2009 Aug 31.
31. Lodwick D, etal., Biochem J. 2014 Dec 15;464(3):343-54. doi: 10.1042/BJ20140273.
32. Lybaert P, etal., Placenta. 2013 Jun;34(6):467-73. doi: 10.1016/j.placenta.2013.03.006. Epub 2013 Apr 13.
33. Marthinet E, etal., J Clin Endocrinol Metab. 2005 Sep;90(9):5401-6. Epub 2005 Jul 5.
34. McDevitt MA, etal., Horm Behav. 2009 Feb;55(2):366-74. Epub 2008 Sep 16.
35. MGD data from the GO Consortium
36. Mohnike K, etal., Horm Res Paediatr. 2014;81(3):156-68. doi: 10.1159/000356905. Epub 2014 Jan 7.
37. Moritz W, etal., Endocrinology 2001 Jan;142(1):129-38.
38. Morrissey A, etal., BMC Physiol. 2005 Jan 12;5(1):1.
39. NCBI rat LocusLink and RefSeq merged data July 26, 2002
40. OMIM Disease Annotation Pipeline
41. Pipeline to import KEGG annotations from KEGG into RGD
42. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
43. Pipeline to import SMPDB annotations from SMPDB into RGD
44. Rainbow RD, etal., Biochem J. 2004 Apr 1;379(Pt 1):173-81.
45. RGD automated data pipeline
46. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. RGD automated import pipeline for gene-chemical interactions
48. Riedel MJ, etal., Hum Genet. 2005 Feb;116(3):133-45. Epub 2004 Nov 23.
49. Ruiz N, etal., Brain Res. 2011 Dec 2;1426:86-95. Epub 2011 Oct 8.
50. Salman S, etal., Am J Physiol Cell Physiol. 2012 May 15;302(10):C1531-8. doi: 10.1152/ajpcell.00052.2012. Epub 2012 Mar 7.
51. Shimizu S, etal., Br J Pharmacol. 2011 May;163(2):272-82. doi: 10.1111/j.1476-5381.2011.01231.x.
52. Singh H, etal., J Mol Cell Cardiol. 2003 May;35(5):445-59.
53. Sogno Valin P, etal., Horm Res Paediatr. 2013;79(4):236-42. doi: 10.1159/000350827. Epub 2013 May 1.
54. Stancakova A, etal., Diabetes. 2009 Jun 5.
55. Sun W and Hu K, Cell Physiol Biochem. 2010;25(4-5):409-18. doi: 10.1159/000303045. Epub 2010 Mar 23.
56. Tagmose TM, etal., J Med Chem. 2004 Jun 3;47(12):3202-11.
57. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
58. Tokuyama Y, etal., Biochem Biophys Res Commun 1996 Mar 27;220(3):532-8.
59. Wan TC, etal., J Pharmacol Exp Ther. 2008 Jan;324(1):234-43. Epub 2007 Sep 28.
60. Wang S, etal., Neuropharmacology. 2005 Jun;48(7):984-92.
61. Wang W, etal., J Tradit Chin Med. 2015 Oct;35(5):577-82.
62. Wu SN, etal., Life Sci. 2007 Jan 2;80(4):378-87. Epub 2006 Oct 17.
63. Yan FF, etal., Mol Biol Cell. 2010 Jun 15;21(12):1945-54. Epub 2010 Apr 28.
64. Yin XF, etal., Eur Neurol. 2007;57(1):4-10. Epub 2006 Nov 14.
65. Zhang D, etal., Neuroreport. 2012 Nov 14;23(16):952-7. doi: 10.1097/WNR.0b013e3283598de6.
66. Zhou D, etal., J Hum Genet. 2009 Jun 5.
67. Zhou M, etal., Anat Rec (Hoboken). 2011 Apr;294(4):729-37. doi: 10.1002/ar.21348. Epub 2011 Feb 15.
68. Zhou M, etal., Brain Res Mol Brain Res 2002 May 30;101(1-2):23-32.
69. Zhou M, etal., J Histochem Cytochem. 2005 Dec;53(12):1491-500. Epub 2005 Jun 27.
70. Zhou Q, etal., Channels (Austin). 2013 Jul-Aug;7(4):313-7. Epub 2013 May 21.
71. Zoga V, etal., Mol Pain. 2010 Jan 26;6:6. doi: 10.1186/1744-8069-6-6.
Additional References at PubMed
PMID:8630239   PMID:8798681   PMID:8889548   PMID:8923010   PMID:12860923   PMID:14592811   PMID:15044189   PMID:15166124   PMID:15528203   PMID:15583126   PMID:15613469   PMID:15739238  
PMID:15775962   PMID:15784703   PMID:16085792   PMID:16537788   PMID:16731837   PMID:16956886   PMID:17311891   PMID:18006464   PMID:18073297   PMID:18250167   PMID:18776135   PMID:19141293  
PMID:19151370   PMID:19464385   PMID:19933268   PMID:20008464   PMID:20456845   PMID:20610380   PMID:21145327   PMID:21193530   PMID:21321069   PMID:21474909   PMID:21482559   PMID:21654216  
PMID:22144717   PMID:22257425   PMID:22480512   PMID:22636679   PMID:22802363   PMID:23219002   PMID:23418587   PMID:23700433   PMID:24014680   PMID:24429282   PMID:24480471   PMID:25073062  
PMID:27430376   PMID:28082085   PMID:28092267   PMID:30074836   PMID:30868916  


Genomics

Comparative Map Data
Kcnj11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,591,048 - 96,594,574 (-)NCBI
Rnor_6.0 Ensembl1102,103,094 - 102,106,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01102,103,093 - 102,107,134 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01103,186,859 - 103,190,535 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,614,960 - 96,617,993 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,693,070 - 96,696,104 (-)NCBI
Celera190,842,071 - 90,845,104 (-)NCBICelera
Cytogenetic Map1q22NCBI
KCNJ11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1117,365,172 - 17,389,331 (-)EnsemblGRCh38hg38GRCh38
GRCh381117,385,246 - 17,389,346 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371117,406,795 - 17,410,893 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,363,371 - 17,366,782 (-)NCBINCBI36hg18NCBI36
Build 341117,364,788 - 17,366,737NCBI
Celera1117,536,622 - 17,540,705 (-)NCBI
Cytogenetic Map11p15.1NCBI
HuRef1117,090,617 - 17,094,700 (-)NCBIHuRef
CHM1_11117,406,598 - 17,410,681 (-)NCBICHM1_1
Kcnj11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,746,547 - 45,750,376 (-)NCBIGRCm39mm39
GRCm39 Ensembl745,743,377 - 45,750,188 (-)Ensembl
GRCm38746,097,123 - 46,100,952 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,093,953 - 46,100,764 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,352,532 - 53,355,607 (-)NCBIGRCm37mm9NCBIm37
MGSCv36745,965,204 - 45,968,279 (-)NCBImm8
Celera741,570,483 - 41,573,555 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.66NCBI
Kcnj11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,210,545 - 32,211,717 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541432,209,426 - 32,212,424 (-)NCBIChiLan1.0ChiLan1.0
KCNJ11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11117,125,885 - 17,129,579 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,127,557 - 17,128,729 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01117,440,522 - 17,444,075 (-)NCBIMhudiblu_PPA_v0panPan3
KCNJ11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12139,953,461 - 39,957,615 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2139,955,551 - 39,956,723 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2139,454,228 - 39,457,833 (-)NCBI
ROS_Cfam_1.02141,059,361 - 41,062,966 (-)NCBI
UMICH_Zoey_3.12140,072,057 - 40,075,662 (-)NCBI
UNSW_CanFamBas_1.02140,279,502 - 40,283,108 (-)NCBI
UU_Cfam_GSD_1.02140,618,209 - 40,621,814 (-)NCBI
Kcnj11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,651,254 - 45,654,240 (+)NCBI
SpeTri2.0NW_0049365281,685,015 - 1,688,220 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,757,356 - 41,765,555 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1241,756,637 - 41,760,340 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,815,173 - 44,817,370 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1147,582,519 - 47,586,466 (+)NCBI
ChlSab1.1 Ensembl147,583,629 - 47,584,801 (+)Ensembl
Vero_WHO_p1.0NW_023666038145,013,121 - 145,016,726 (+)NCBI
Kcnj11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247669,012,166 - 9,015,269 (-)NCBI

Position Markers
PMC312732P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,592,815 - 96,593,315 (+)MAPPER
Rnor_6.01102,104,861 - 102,105,360NCBIRnor6.0
Rnor_5.01103,188,626 - 103,189,125UniSTSRnor5.0
RGSC_v3.4196,616,727 - 96,617,226UniSTSRGSC3.4
Celera190,843,838 - 90,844,337UniSTS
Cytogenetic Map1q22UniSTS
RH130776  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,591,617 - 96,591,832 (+)MAPPER
Rnor_6.01102,103,663 - 102,103,877NCBIRnor6.0
Rnor_5.01103,187,428 - 103,187,642UniSTSRnor5.0
RGSC_v3.4196,615,529 - 96,615,743UniSTSRGSC3.4
Celera190,842,640 - 90,842,854UniSTS
RH 3.4 Map1909.4UniSTS
Cytogenetic Map1q22UniSTS
BE113377  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,591,122 - 96,591,288 (+)MAPPER
Rnor_6.01102,103,168 - 102,103,333NCBIRnor6.0
Rnor_5.01103,186,933 - 103,187,098UniSTSRnor5.0
RGSC_v3.4196,615,034 - 96,615,199UniSTSRGSC3.4
Celera190,842,145 - 90,842,310UniSTS
RH 3.4 Map1908.9UniSTS
Cytogenetic Map1q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15655769122614963Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123406428108057505Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)125951907130917265Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143579208126240667Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143579208126240667Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143579208126240667Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143579208126240667Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143579208126240667Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)149147799156446783Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157761301104391981Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)158209327103209327Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)158354072161711996Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)164588516125875986Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)166113339122614963Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)179134941113593716Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)179689548124689548Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)183502376128502376Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)183656882126240667Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185779320130779320Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185917265130917265Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)186776571131776571Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)188634585106002500Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)190804143161321256Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)191093646136093646Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)194201400184846632Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)194201400197187904Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)194225372130917265Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194364073153076991Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)195304961156446783Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)199983293127203999Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)199983293188289386Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)199983293198656062Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)199983293216213510Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)199983293216325819Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100131562236763528Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100354344145354344Rat


Genetic Models
This gene Kcnj11 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:100
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000028685
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 33 8 11 15 8
Low 2 10 14 2 5 2 59 23 30 8
Below cutoff 1 25 21 14 21 12 11 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB043638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC120807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW527189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF565039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D61687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U44897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000028685   ⟹   ENSRNOP00000028685
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1102,103,094 - 102,106,127 (-)Ensembl
RefSeq Acc Id: NM_031358   ⟹   NP_112648
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,591,049 - 96,594,082 (-)NCBI
Rnor_6.01102,103,094 - 102,106,127 (-)NCBI
Rnor_5.01103,186,859 - 103,190,535 (-)NCBI
RGSC_v3.4196,614,960 - 96,617,993 (-)RGD
Celera190,842,071 - 90,845,104 (-)RGD
Sequence:
RefSeq Acc Id: XM_008759421   ⟹   XP_008757643
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,591,048 - 96,594,574 (-)NCBI
Rnor_6.01102,103,093 - 102,107,134 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589780   ⟹   XP_017445269
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,591,048 - 96,594,572 (-)NCBI
Rnor_6.01102,103,093 - 102,106,883 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589782   ⟹   XP_017445271
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,591,049 - 96,594,503 (-)NCBI
Rnor_6.01102,103,093 - 102,106,539 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092510   ⟹   XP_038948438
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,591,048 - 96,594,542 (-)NCBI
RefSeq Acc Id: XM_039092515   ⟹   XP_038948443
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,591,049 - 96,594,503 (-)NCBI
RefSeq Acc Id: XM_039092522   ⟹   XP_038948450
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,591,049 - 96,594,503 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_112648   ⟸   NM_031358
- UniProtKB: P70673 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008757643   ⟸   XM_008759421
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017445269   ⟸   XM_017589780
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017445271   ⟸   XM_017589782
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000028685   ⟸   ENSRNOT00000028685
RefSeq Acc Id: XP_038948438   ⟸   XM_039092510
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038948450   ⟸   XM_039092522
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038948443   ⟸   XM_039092515
- Peptide Label: isoform X3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69247 AgrOrtholog
Ensembl Genes ENSRNOG00000021128 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000028685 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028685 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.1400 UniProtKB/Swiss-Prot
InterPro Ig_E-set UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir6.2 UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot
  Kir_TM UniProtKB/Swiss-Prot
KEGG Report rno:83535 UniProtKB/Swiss-Prot
NCBI Gene 83535 ENTREZGENE
PANTHER PTHR11767 UniProtKB/Swiss-Prot
  PTHR11767:SF44 UniProtKB/Swiss-Prot
Pfam IRK UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
PharmGKB KCNJ11 RGD
PhenoGen Kcnj11 PhenoGen
PIRSF GIRK_kir UniProtKB/Swiss-Prot
PRINTS KIR62CHANNEL UniProtKB/Swiss-Prot
  KIRCHANNEL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot
TIGR TC216683
UniProt KCJ11_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q62906 UniProtKB/Swiss-Prot
  Q9JM48 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Kcnj11  potassium inwardly rectifying channel, subfamily J, member 11      Symbol and Name status set to approved 1299863 APPROVED
2002-07-25 Kir6.2  potassium inwardly rectifying channel, subfamily J, member 11      gene retired, merged with Kcnj11 (RGD:69247) 61033 WITHDRAWN
2002-06-10 Kcnj11  potassium inwardly rectifying channel, subfamily J, member 11      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in vascular smooth muscle cells 724755