Adora2a (adenosine A2a receptor) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Adora2a (adenosine A2a receptor) Rattus norvegicus
Analyze
Symbol: Adora2a
Name: adenosine A2a receptor
RGD ID: 2049
Description: Exhibits G protein-coupled adenosine receptor activity; alpha-actinin binding activity; and type 5 metabotropic glutamate receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; chemical synaptic transmission; and regulation of secretion. Localizes to several cellular components, including axolemma; integral component of synaptic membrane; and postsynaptic density. Colocalizes with intermediate filament. Used to study lung disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA2A (adenosine A2a receptor); PARTICIPATES IN adenosine signaling pathway; hypoxia inducible factor pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (S)-AMPA; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A2ar; ADENO; adenosine A2a-receptor; adenosine receptor A2a; Adora2l1; MGC93190
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Adora2am1Mcwi   Adora2am2Mcwi   Adora2am3Mcwi   Adora2aem3Mcwi   Adora2aem5Mcwi  
Genetic Models: SS-Adora2aem5Mcwi SS-Adora2aem3Mcwi BN-Adora2am1Mcwi BN-Adora2am2Mcwi BN-Adora2am3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22013,315,848 - 13,333,386 (-)NCBI
Rnor_6.0 Ensembl2014,265,252 - 14,282,873 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02014,265,251 - 14,282,873 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02016,449,385 - 16,466,147 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,815,719 - 13,834,131 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12013,815,944 - 13,825,845 (-)NCBI
Celera2014,801,379 - 14,818,841 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
(S)-AMPA  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
8-(3-chlorostyryl)caffeine  (EXP,ISO)
acetamide  (EXP)
acetylcholine  (EXP)
acetylsalicylic acid  (ISO)
adenosine  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (ISO)
aripiprazole  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
cadmium selenide  (ISO)
caffeine  (EXP,ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGS-21680  (EXP,ISO)
cisplatin  (ISO)
clozapine  (ISO)
cocaine  (ISO)
cordycepin  (EXP)
curcumin  (ISO)
cytidine  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP)
DPCPX  (ISO)
elemental selenium  (ISO)
ethanol  (EXP,ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
gamma-aminobutyric acid  (EXP)
graphite  (EXP)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
haloperidol  (ISO)
istradefylline  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
modafinil  (EXP)
morphine  (ISO)
Moxonidine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nicotinic acid  (ISO)
ochratoxin A  (ISO)
orphenadrine  (EXP)
oxidopamine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
pentetrazol  (ISO)
phencyclidine  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
piroxicam  (ISO)
prazosin  (EXP)
prednisolone  (ISO)
propanal  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
sarin  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium aurothiomalate  (ISO)
Soman  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
taurine  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
WIN 55212-2  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IMP,ISO)
astrocyte activation  (IMP)
eating behavior  (IMP,ISO)
excitatory postsynaptic potential  (IDA)
G protein-coupled adenosine receptor signaling pathway  (IDA,ISO)
G protein-coupled receptor signaling pathway  (ISO)
inhibitory postsynaptic potential  (ISO)
locomotory behavior  (IMP,ISO)
membrane depolarization  (IMP)
negative regulation of alpha-beta T cell activation  (ISO)
negative regulation of cell population proliferation  (IDA)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IDA)
negative regulation of inflammatory response  (ISO)
negative regulation of locomotion  (IDA)
negative regulation of neuron apoptotic process  (IDA)
negative regulation of protein kinase activity  (IDA)
negative regulation of vascular permeability  (IMP)
neuron projection morphogenesis  (IDA,IMP)
positive regulation of acetylcholine secretion, neurotransmission  (IMP)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of circadian sleep/wake cycle, sleep  (IDA)
positive regulation of glutamate secretion  (IDA)
positive regulation of long-term synaptic potentiation  (IMP)
positive regulation of protein secretion  (IDA)
positive regulation of renal sodium excretion  (IDA,IMP)
positive regulation of synaptic transmission, GABAergic  (ISO)
positive regulation of synaptic transmission, glutamatergic  (IDA)
positive regulation of urine volume  (IMP)
prepulse inhibition  (IMP)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IDA)
regulation of calcium ion transport  (IMP)
regulation of mitochondrial membrane potential  (IDA)
regulation of norepinephrine secretion  (IMP)
regulation of synaptic vesicle exocytosis  (EXP,IDA)
regulation of transcription, DNA-templated  (IDA)
response to alkaloid  (IMP)
response to amphetamine  (ISO)
response to caffeine  (IDA)
response to drug  (IEP)
synaptic transmission, cholinergic  (IMP)
synaptic transmission, dopaminergic  (ISO)
synaptic transmission, glutamatergic  (IDA)
vasodilation  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Almeida T, etal., Neuroscience. 2003;122(1):111-21.
2. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Bonneau O, etal., Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L1036-43. Epub 2005 Dec 9.
4. Brambilla R, etal., Glia. 2003 Aug;43(2):190-4.
5. Burgueno J, etal., J Biol Chem 2003 Sep 26;278(39):37545-52. Epub 2003 Jul 01.
6. Carriba P, etal., Neuropsychopharmacology. 2007 Nov;32(11):2249-59. Epub 2007 Mar 14.
7. Carroll MA, etal., Am J Physiol Renal Physiol. 2006 Jul;291(1):F155-61. Epub 2006 Feb 14.
8. Charles MP, etal., Biochem Biophys Res Commun. 2003 May 16;304(4):795-800.
9. Chen CM, etal., Crit Care Med. 2009 Jul;37(7):2235-41.
10. Ciruela F, etal., J Neurosci. 2006 Feb 15;26(7):2080-7.
11. Donoso MV, etal., J Neurochem. 2006 Mar;96(6):1680-95.
12. Duarte JM, etal., Neurochem Int. 2006 Jan;48(2):144-50. Epub 2005 Oct 26.
13. Ellman PI, etal., J Surg Res. 2008 Sep;149(1):3-8. Epub 2007 Sep 12.
14. Ferre S, etal., Proc Natl Acad Sci U S A 2002 Sep 3;99(18):11940-5.
15. Fink JS, etal., Brain Res Mol Brain Res 1992 Jul;14(3):186-95.
16. Gardner AM and Olah ME, J Biol Chem. 2003 Apr 25;278(17):15421-8. Epub 2003 Feb 17.
17. GOA data from the GO Consortium
18. Hasko G, etal., Crit Care Med. 2006 Apr;34(4):1119-25.
19. Kim SH, etal., Respir Med. 2009 Mar;103(3):356-63. Epub 2008 Nov 18.
20. Lau CL, etal., Ann Thorac Surg. 2009 Oct;88(4):1071-8.
21. Ledent C, etal., Nature 1997 Aug 14;388(6643):674-8.
22. Magalhaes-Cardoso MT, etal., J Physiol. 2003 Jun 1;549(Pt 2):399-408. Epub 2003 Apr 4.
23. Methippara MM, etal., Am J Physiol Regul Integr Comp Physiol. 2005 Dec;289(6):R1715-23. Epub 2005 Aug 18.
24. MGD data from the GO Consortium
25. Mohsenin A, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L753-61. Epub 2007 Jun 29.
26. Nadeem A, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1335-44. Epub 2007 Feb 9.
27. Nagel J, etal., Synapse. 2003 Sep 15;49(4):279-86.
28. NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Ohata H, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Sep;291(3):R728-35. Epub 2006 Apr 6.
30. Ohta A and Sitkovsky M, Nature 2001 Dec 20-27;414(6866):916-20.
31. Okada M, etal., Nihon Shinkei Seishin Yakurigaku Zasshi 2002 Apr;22(2):61-9.
32. Oliveira L, etal., J Physiol. 2004 Oct 1;560(Pt 1):157-68. Epub 2004 Aug 5.
33. Petrov T, etal., J Spinal Cord Med. 2007;30(4):331-7.
34. Pickel VM, etal., Synapse. 2006 Dec 1;60(7):496-509.
35. Pipeline to import KEGG annotations from KEGG into RGD
36. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
37. Pipeline to import SMPDB annotations from SMPDB into RGD
38. Ponnoth DS, etal., Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2158-65. Epub 2008 Feb 29.
39. Ponzio TA, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Aug;291(2):R359-66. Epub 2006 Apr 27.
40. Ramirez SH, etal., J Neurosci Res. 2004 Jul 15;77(2):258-69.
41. Reutershan J, etal., J Immunol. 2007 Jul 15;179(2):1254-63.
42. RGD automated data pipeline
43. RGD automated import pipeline for gene-chemical interactions
44. Rodrigues RJ, etal., J Neurochem. 2005 Feb;92(3):433-41.
45. Scheibner KA, etal., Am J Respir Cell Mol Biol. 2009 Mar;40(3):251-9. Epub 2008 Aug 14.
46. Sharma AK, etal., J Thorac Cardiovasc Surg. 2010 Feb;139(2):474-82. Epub 2009 Nov 11.
47. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
48. Sun CN, etal., Mol Pharmacol. 2006 Aug;70(2):454-66. Epub 2006 Apr 14.
49. Wallace KL and Linden J, Blood. 2010 Dec 2;116(23):5010-20. Epub 2010 Aug 26.
50. Wang J and Huxley VH, Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H3094-105. Epub 2006 Jun 30.
51. Wright K, etal., J Hypertens. 2004 Aug;22(8):1519-22.
52. Wu YC, etal., Biochim Biophys Acta. 2013 Dec;1833(12):3145-3154. doi: 10.1016/j.bbamcr.2013.08.009. Epub 2013 Aug 27.
53. Yao L, etal., Proc Natl Acad Sci U S A. 2006 May 16;103(20):7877-82. Epub 2006 May 9.
54. Yip L and Kwok YN, J Pharmacol Exp Ther. 2004 May;309(2):804-15. Epub 2004 Jan 23.
55. Zimmer MB and Goshgarian HG, Exp Neurol. 2007 Jul;206(1):137-45. Epub 2007 May 8.
56. Zou AP, etal., Am J Physiol 1999 Mar;276(3 Pt 2):R790-8.
Additional References at PubMed
PMID:1599465   PMID:8639269   PMID:8738226   PMID:9269779   PMID:10069416   PMID:10537036   PMID:10704492   PMID:10845921   PMID:10908627   PMID:10934242   PMID:11172060   PMID:11248116  
PMID:11404425   PMID:12167481   PMID:12223546   PMID:12538862   PMID:12654506   PMID:12694400   PMID:12817016   PMID:12832562   PMID:12904509   PMID:14622213   PMID:15044529   PMID:15197743  
PMID:15489334   PMID:15539419   PMID:15689617   PMID:16280580   PMID:16339847   PMID:16413509   PMID:16683708   PMID:16980350   PMID:17181659   PMID:17304576   PMID:17421024   PMID:17481781  
PMID:17516542   PMID:17517168   PMID:17519974   PMID:17548208   PMID:17556415   PMID:17619122   PMID:17664389   PMID:17689978   PMID:17898087   PMID:17934014   PMID:18054436   PMID:18057956  
PMID:18218631   PMID:18313046   PMID:18360306   PMID:18499627   PMID:18506850   PMID:18584206   PMID:18675812   PMID:18800071   PMID:18849328   PMID:19013155   PMID:19110076   PMID:19138885  
PMID:19200339   PMID:19202001   PMID:19204055   PMID:19407255   PMID:19422385   PMID:19467297   PMID:19619617   PMID:19632986   PMID:19666061   PMID:19695259   PMID:19723291   PMID:19801629  
PMID:19822132   PMID:19908252   PMID:20143408   PMID:20385128   PMID:20519378   PMID:20797711   PMID:21062287   PMID:21080412   PMID:21106859   PMID:21144776   PMID:21235574   PMID:21289195  
PMID:21393508   PMID:21443689   PMID:21508927   PMID:21593763   PMID:21615561   PMID:21703281   PMID:21742019   PMID:21867705   PMID:21983553   PMID:22064330   PMID:22298379   PMID:22371048  
PMID:22401823   PMID:22528231   PMID:22715379   PMID:23013133   PMID:23032401   PMID:23154210   PMID:23261865   PMID:23587453   PMID:23637137   PMID:23638679   PMID:23770463   PMID:23783558  
PMID:23965991   PMID:24014158   PMID:24271058   PMID:24293369   PMID:24361450   PMID:24704558   PMID:24777042   PMID:24845382   PMID:24872568   PMID:24912137   PMID:25296982   PMID:25401477  
PMID:25716780   PMID:25891445   PMID:25907806   PMID:25910812   PMID:25936513   PMID:26068054   PMID:26526685   PMID:26728617   PMID:27060487   PMID:27757725   PMID:28294142   PMID:28981089  
PMID:29217157   PMID:29360563   PMID:29568380   PMID:29587249   PMID:29693117   PMID:30017837   PMID:30220081   PMID:30461068   PMID:30507864   PMID:30541517   PMID:31161847   PMID:31206753  


Genomics

Comparative Map Data
Adora2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22013,315,848 - 13,333,386 (-)NCBI
Rnor_6.0 Ensembl2014,265,252 - 14,282,873 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02014,265,251 - 14,282,873 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02016,449,385 - 16,466,147 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,815,719 - 13,834,131 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12013,815,944 - 13,825,845 (-)NCBI
Celera2014,801,379 - 14,818,841 (-)NCBICelera
Cytogenetic Map20p12NCBI
ADORA2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2224,417,879 - 24,442,357 (+)EnsemblGRCh38hg38GRCh38
GRCh382224,423,597 - 24,442,357 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372224,819,565 - 24,838,325 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh372224,819,565 - 24,838,328 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,153,530 - 23,168,325 (+)NCBINCBI36hg18NCBI36
Build 342223,153,645 - 23,162,878NCBI
Celera228,623,253 - 8,638,061 (+)NCBI
Cytogenetic Map22q11.23NCBI
HuRef227,769,458 - 7,788,241 (+)NCBIHuRef
CHM1_12224,778,238 - 24,796,999 (+)NCBICHM1_1
Adora2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,152,711 - 75,170,626 (+)NCBIGRCm39mm39
GRCm381075,316,877 - 75,334,792 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,316,877 - 75,334,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv371074,779,688 - 74,797,533 (+)NCBIGRCm37mm9NCBIm37
MGSCv361074,769,745 - 74,777,652 (+)NCBImm8
Celera1076,364,032 - 76,382,114 (+)NCBICelera
Cytogenetic Map10C1NCBI
Adora2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554557,895,974 - 7,906,505 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554557,886,720 - 7,906,214 (+)NCBIChiLan1.0ChiLan1.0
ADORA2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12222,099,404 - 22,114,189 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,104,253 - 22,114,189 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0225,233,876 - 5,248,622 (+)NCBIMhudiblu_PPA_v0panPan3
ADORA2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2628,141,076 - 28,150,598 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12628,141,076 - 28,150,600 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Adora2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936619597,970 - 618,564 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADORA2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,468,862 - 49,485,841 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,467,186 - 49,485,845 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,914,635 - 52,931,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADORA2A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,691,678 - 7,706,781 (-)NCBI
ChlSab1.1 Ensembl197,691,536 - 7,706,926 (-)Ensembl
Adora2a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247479,846,254 - 9,860,938 (+)NCBI

Position Markers
RH129254  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02014,265,259 - 14,265,428NCBIRnor6.0
Rnor_5.02016,449,392 - 16,449,561UniSTSRnor5.0
RGSC_v3.42013,815,726 - 13,815,895UniSTSRGSC3.4
Celera2014,801,386 - 14,801,555UniSTS
Cytogenetic Map20p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124652101Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125653396Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20127357423Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20128375393Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20128375393Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20128375393Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20128375393Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20128375393Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20133300419Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20137550487Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20137550487Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20340211127968216Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20403911318872273Rat
4889857Pur27Proteinuria QTL 2712.20.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20403911318872273Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)20410895649108956Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20485547515050565Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20587544818739210Rat
1581577Pur15Proteinuria QTL 154.380.0002total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20865434118872273Rat
4889870Pur30Proteinuria QTL 30190.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20865434130991290Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20965564214411641Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201383430956205956Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201383430956205956Rat


Genetic Models
This gene Adora2a is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:340
Count of miRNA genes:207
Interacting mature miRNAs:247
Transcripts:ENSRNOT00000001759
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 15 8 2 8 2 26 4 10
Low 3 28 49 39 11 39 8 11 48 35 30 1 8
Below cutoff 7

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF107208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF115508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF228684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR477522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ098650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L08102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M91214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S47609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000001759   ⟹   ENSRNOP00000001759
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2014,265,252 - 14,282,873 (-)Ensembl
RefSeq Acc Id: NM_001357942   ⟹   NP_001344871
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,315,853 - 13,333,386 (-)NCBI
RefSeq Acc Id: NM_053294   ⟹   NP_445746
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,315,853 - 13,333,386 (-)NCBI
Rnor_6.02014,265,252 - 14,282,873 (-)NCBI
Rnor_5.02016,449,385 - 16,466,147 (-)NCBI
RGSC_v3.42013,815,719 - 13,834,131 (-)RGD
Celera2014,801,379 - 14,818,841 (-)RGD
Sequence:
RefSeq Acc Id: XM_017601552   ⟹   XP_017457041
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,315,848 - 13,333,191 (-)NCBI
Rnor_6.02014,265,251 - 14,282,672 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601553   ⟹   XP_017457042
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,315,848 - 13,325,747 (-)NCBI
Rnor_6.02014,265,251 - 14,275,627 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601554   ⟹   XP_017457043
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,315,848 - 13,327,185 (-)NCBI
Rnor_6.02014,265,251 - 14,278,841 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601555   ⟹   XP_017457044
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,315,848 - 13,332,734 (-)NCBI
Rnor_6.02014,265,251 - 14,282,373 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098455   ⟹   XP_038954383
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,315,848 - 13,331,666 (-)NCBI
RefSeq Acc Id: XM_039098456   ⟹   XP_038954384
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,315,848 - 13,333,191 (-)NCBI
RefSeq Acc Id: XM_039098457   ⟹   XP_038954385
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,315,848 - 13,330,221 (-)NCBI
RefSeq Acc Id: XM_039098458   ⟹   XP_038954386
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,315,848 - 13,330,332 (-)NCBI
RefSeq Acc Id: XM_039098459   ⟹   XP_038954387
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,315,848 - 13,320,014 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_445746   ⟸   NM_053294
- Peptide Label: A2AR
- UniProtKB: P30543 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017457041   ⟸   XM_017601552
- Peptide Label: isoform X1
- UniProtKB: P30543 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017457044   ⟸   XM_017601555
- Peptide Label: isoform X1
- UniProtKB: P30543 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017457043   ⟸   XM_017601554
- Peptide Label: isoform X1
- UniProtKB: P30543 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017457042   ⟸   XM_017601553
- Peptide Label: isoform X1
- UniProtKB: P30543 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001759   ⟸   ENSRNOT00000001759
RefSeq Acc Id: XP_038954384   ⟸   XM_039098456
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954383   ⟸   XM_039098455
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954386   ⟸   XM_039098458
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954385   ⟸   XM_039098457
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954387   ⟸   XM_039098459
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001344871   ⟸   NM_001357942
- Peptide Label: uORF5

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 13817030 13817031 C A snv SS/JrHsdMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2049 AgrOrtholog
Ensembl Genes ENSRNOG00000001302 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000001759 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001759 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7121208 IMAGE-MGC_LOAD
InterPro Adeno_A2A_rcpt UniProtKB/Swiss-Prot
  Adenosn_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:25369 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93190 IMAGE-MGC_LOAD
NCBI Gene 25369 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB ADORA2A RGD
PhenoGen Adora2a PhenoGen
PRINTS ADENOSINA2AR UniProtKB/Swiss-Prot
  ADENOSINER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt AA2AR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-30 Adora2a  adenosine A2a receptor  Adora2l1    Data Merged 737654 APPROVED
2002-11-06 Adora2a  adenosine A2a receptor    Adenosine A2a-receptor  Name updated 625702 APPROVED
2002-08-07 Adora2l1        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Adora2a  Adenosine A2a-receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain striatum 631807
gene_expression expression in straital neurons is coincident with D2 dopamine receptor expression, however, co-expression with D1 dopamine receptor is not detected 631807
gene_expression highly expressed in the aminobutyric acid (GABA)ergic striatopallidal neurons of striatum 628573
gene_expression 3,7-dimethyl-1-prparglylxanthine (DMPX) decreases outer and inner medullary blood flows, urine flow and sodium excretion 628573
gene_function diuretic and natriuretic adenosine receptor 628573
gene_function G-protein coupled receptor for adenoisne 625594
gene_process may be involved in regulation of motor behavior 631807
gene_process modulates glutamatergic input to striatal GABAergic neurons 625594
gene_process acts synergistically with glutamate mGlu5 receptor to increase c-fos expression in striatal sections and on counteracting phencyclidine-induced motor activation 628573
gene_process may promote adenosine mediated dilation of medullary vessels and increase medullary blood flow 628573
gene_product member of the G-protein coupled receptor family 631807
gene_regulation upon activation dilates pre- and postglomerular vessels and inhibits reabsorption of tubular sodium 628573