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Gene: Adora2a (adenosine A2a receptor) Rattus norvegicus
Symbol: Adora2a
Name: adenosine A2a receptor
RGD ID: 2049
Description: Exhibits G protein-coupled adenosine receptor activity; alpha-actinin binding activity; and type 5 metabotropic glutamate receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; chemical synaptic transmission; and regulation of secretion. Localizes to several cellular components, including axolemma; integral component of synaptic membrane; and postsynaptic density. Colocalizes with intermediate filament. Used to study lung disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA2A (adenosine A2a receptor); PARTICIPATES IN adenosine signaling pathway; hypoxia inducible factor pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (S)-AMPA; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A2ar; ADENO; adenosine A2a-receptor; adenosine receptor A2a; Adora2l1; MGC93190
Homo sapiens (human) : ADORA2A (adenosine A2a receptor)  HGNC  Alliance
Mus musculus (house mouse) : Adora2a (adenosine A2a receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adora2a (adenosine A2a receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : ADORA2A (adenosine A2a receptor)
Canis lupus familiaris (dog) : ADORA2A (adenosine A2a receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adora2a (adenosine A2a receptor)
Sus scrofa (pig) : ADORA2A (adenosine A2a receptor)
Chlorocebus sabaeus (African green monkey) : ADORA2A (adenosine A2a receptor)
Heterocephalus glaber (naked mole-rat) : Adora2a (adenosine A2a receptor)
more info ...
Allele / Splice: Adora2am1Mcwi   Adora2am2Mcwi   Adora2am3Mcwi   Adora2aem3Mcwi   Adora2aem5Mcwi  
Genetic Models: SS-Adora2aem5Mcwi SS-Adora2aem3Mcwi BN-Adora2am1Mcwi BN-Adora2am2Mcwi BN-Adora2am3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02014,265,251 - 14,282,873 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,265,252 - 14,282,873 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,449,385 - 16,466,147 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,815,719 - 13,834,131 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12013,815,944 - 13,825,845 (-)NCBI
Celera2014,801,379 - 14,818,841 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Adora2a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2049
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.