ADORA1 (adenosine A1 receptor) - Rat Genome Database
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Gene: ADORA1 (adenosine A1 receptor) Homo sapiens
Analyze
Symbol: ADORA1
Name: adenosine A1 receptor
RGD ID: 730817
HGNC Page HGNC
Description: Predicted to have several functions, including G protein-coupled adenosine receptor activity; G-protein beta/gamma-subunit complex binding activity; and heterotrimeric G-protein binding activity. Predicted to be involved in negative regulation of inflammatory response. Localizes to plasma membrane. Implicated in asthma. Biomarker of asthma and obesity.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: adenosine A1 receptor variant 1; adenosine A1 receptor variant 2; adenosine receptor A1; RDC7
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1203,090,654 - 203,167,405 (+)EnsemblGRCh38hg38GRCh38
GRCh381203,127,705 - 203,167,405 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371203,096,854 - 203,136,533 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh371203,096,833 - 203,136,533 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,363,459 - 201,403,156 (+)NCBINCBI36hg18NCBI36
Build 341199,791,438 - 199,868,189NCBI
Celera1176,226,082 - 176,265,774 (+)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1174,262,408 - 174,301,662 (+)NCBIHuRef
CHM1_11204,519,171 - 204,558,852 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
adenosine  (EXP,ISO)
aflatoxin B1  (EXP)
aflatoxin B2  (EXP)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
butanal  (EXP)
C60 fullerene  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (ISO)
citalopram  (ISO)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
corticosterone  (ISO)
cytidine  (ISO)
dibutyl phthalate  (ISO)
diethyl pyrocarbonate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
dithionitrobenzoic acid  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
DPCPX  (EXP,ISO)
edaravone  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
fenvalerate  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
furan  (ISO)
gamma-aminobutyric acid  (ISO)
gefitinib  (EXP)
glycerol  (ISO)
hydrogen peroxide  (EXP)
Indeno[1,2,3-cd]pyrene  (EXP)
indole-3-methanol  (ISO)
L-1,4-dithiothreitol  (ISO)
L-cysteine  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
maneb  (ISO)
mercury dichloride  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (EXP)
mianserin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (EXP)
orphenadrine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
picene  (EXP)
pioglitazone  (ISO)
prazosin  (ISO)
resveratrol  (ISO)
sarin  (EXP)
SB 431542  (EXP)
sunitinib  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
uridine  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
XL147  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPKK activity  (IEA,ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IEA,ISO)
apoptotic signaling pathway  (TAS)
cell-cell signaling  (TAS)
cognition  (IEA,ISO)
detection of temperature stimulus involved in sensory perception of pain  (IEA,ISO)
excitatory postsynaptic potential  (IEA,ISO)
fatty acid homeostasis  (IEA,ISO)
G protein-coupled adenosine receptor signaling pathway  (IEA)
G protein-coupled receptor signaling pathway  (ISO,TAS)
inflammatory response  (TAS)
lipid catabolic process  (IEA,ISO)
negative regulation of acute inflammatory response  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of blood pressure  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of circadian sleep/wake cycle, non-REM sleep  (IEA,ISO)
negative regulation of circadian sleep/wake cycle, sleep  (ISO)
negative regulation of glutamate secretion  (IEA,ISO)
negative regulation of heart contraction  (IEA,ISO)
negative regulation of hormone secretion  (IEA,ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of leukocyte migration  (IEA,ISO)
negative regulation of lipid catabolic process  (IEA,ISO)
negative regulation of long-term synaptic depression  (IEA,ISO)
negative regulation of long-term synaptic potentiation  (IEA,ISO)
negative regulation of mucus secretion  (IEA,ISO)
negative regulation of neurotrophin production  (IEA,ISO)
negative regulation of renal sodium excretion  (IEA,ISO)
negative regulation of synaptic transmission, GABAergic  (IEA,ISO)
negative regulation of synaptic transmission, glutamatergic  (IEA,ISO)
negative regulation of systemic arterial blood pressure  (IEA,ISO)
nervous system development  (TAS)
phagocytosis  (TAS)
positive regulation of blood pressure  (ISO)
positive regulation of epidermal growth factor-activated receptor activity  (IEA,ISO)
positive regulation of lipid catabolic process  (IEA,ISO)
positive regulation of neuron death  (IEA,ISO)
positive regulation of nucleoside transport  (IEA,ISO)
positive regulation of peptide secretion  (IEA,ISO)
positive regulation of potassium ion transport  (IEA,ISO)
positive regulation of protein dephosphorylation  (IEA,ISO)
positive regulation of systemic arterial blood pressure  (IEA,ISO)
protein targeting to membrane  (IEA,ISO)
regulation of cardiac muscle cell contraction  (IEA,ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of glomerular filtration  (IEA,ISO)
regulation of presynaptic cytosolic calcium ion concentration  (IEA)
regulation of respiratory gaseous exchange by nervous system process  (IEA,ISO)
regulation of sensory perception of pain  (IEA,ISO)
relaxation of vascular associated smooth muscle  (IEA,ISO)
response to auditory stimulus  (ISO)
response to hypoxia  (IEA,ISO)
signal transduction  (TAS)
temperature homeostasis  (IEA,ISO)
triglyceride homeostasis  (IEA,ISO)
vasoconstriction  (ISO)
vasodilation  (ISO)

References

References - curated
1. Ajamieh HH, etal., Clin Sci (Lond). 2008 Jul;115(2):69-77.
2. Akaiwa K, etal., Brain Res. 2006 Nov 29;1122(1):47-55. Epub 2006 Oct 24.
3. Balasubramanyan S and Sharma SS, Indian J Physiol Pharmacol. 2008 Jul-Sep;52(3):233-42.
4. Barakat H, etal., J Clin Endocrinol Metab. 2006 May;91(5):1882-6. Epub 2006 Feb 28.
5. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. Brown RA, etal., Eur Respir J. 2008 Feb;31(2):311-9. Epub 2007 Oct 24.
7. Cheng JT, etal., Auton Neurosci. 2000 Oct 2;83(3):127-33.
8. Dong Q, etal., Diabetes Obes Metab. 2001 Oct;3(5):360-6.
9. Duarte JM, etal., Neurochem Int. 2006 Jan;48(2):144-50. Epub 2005 Oct 26.
10. GOA_HUMAN data from the GO Consortium
11. Horiuchi H, etal., Spinal Cord. 2010 Sep;48(9):685-90. Epub 2010 Jan 12.
12. Ishikawa J, etal., Diabetes Res Clin Pract. 1998 Jan;39(1):3-9.
13. Kajana S and Goshgarian HG, Exp Neurol. 2008 Apr;210(2):671-80. Epub 2008 Jan 5.
14. Kim SH, etal., Respir Med. 2009 Mar;103(3):356-63. Epub 2008 Nov 18.
15. McGuire M, etal., J Physiol. 2008 Nov 1;586(Pt 21):5215-29. Epub 2008 Sep 11.
16. Metra M, etal., Eur Heart J. 2011 Mar 8.
17. Ngamsri KC, etal., J Immunol. 2010 Oct 1;185(7):4374-84. Epub 2010 Aug 20.
18. Perlini S, etal., J Hypertens. 2007 Feb;25(2):449-54.
19. Petrov T, etal., J Spinal Cord Med. 2007;30(4):331-7.
20. Ponnoth DS, etal., Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H81-7. Epub 2010 Apr 16.
21. RGD automated import pipeline for gene-chemical interactions
22. Schoelch C, etal., Diabetes. 2004 Jul;53(7):1920-6.
23. Schrier DJ, etal., J Immunol. 1990 Sep 15;145(6):1874-9.
24. Sun CX, etal., J Clin Invest. 2005 Jan;115(1):35-43.
25. Sun D, etal., Proc Natl Acad Sci U S A 2001 Aug 14;98(17):9983-8.
26. Turner CP, etal., Neuroreport. 2002 Jul 2;13(9):1199-204.
27. Uehara Y, etal., Am J Hypertens. 1995 Dec;8(12 Pt 1):1189-99.
28. Vallon V, etal., Nephron Physiol. 2009;111(3):p30-8. Epub 2009 Mar 10.
29. Wright K, etal., J Hypertens. 2004 Aug;22(8):1519-22.
Additional References at PubMed
PMID:1339301   PMID:1530647   PMID:1551861   PMID:1662665   PMID:2541503   PMID:2825071   PMID:7601478   PMID:7818494   PMID:8300646   PMID:8360491   PMID:8450977   PMID:8889548  
PMID:9166747   PMID:9247966   PMID:10455026   PMID:10487528   PMID:10502296   PMID:10521440   PMID:10890919   PMID:11278325   PMID:11369591   PMID:11390975   PMID:11934694   PMID:12150791  
PMID:12475223   PMID:12477932   PMID:12764156   PMID:12773115   PMID:12812995   PMID:12825092   PMID:12826838   PMID:12920396   PMID:12974671   PMID:14702039   PMID:14997566   PMID:15485865  
PMID:15489334   PMID:16118787   PMID:16344560   PMID:16481441   PMID:16709961   PMID:16713569   PMID:17088462   PMID:17542617   PMID:17728764   PMID:17901362   PMID:18052973   PMID:18240029  
PMID:18281812   PMID:18373090   PMID:18500760   PMID:18577758   PMID:18680557   PMID:18996102   PMID:19019012   PMID:19047957   PMID:19193874   PMID:19207864   PMID:19536175   PMID:19558453  
PMID:19574994   PMID:19794965   PMID:19820430   PMID:19822392   PMID:19883624   PMID:19913121   PMID:19919976   PMID:20085598   PMID:20105183   PMID:20354569   PMID:20392501   PMID:20468064  
PMID:20599769   PMID:20602615   PMID:20609566   PMID:20628086   PMID:21506953   PMID:21542986   PMID:21590734   PMID:21603615   PMID:21701065   PMID:21730968   PMID:21988832   PMID:22215671  
PMID:22356216   PMID:22370739   PMID:22449383   PMID:22462821   PMID:22787201   PMID:22867902   PMID:23193172   PMID:23291003   PMID:23657626   PMID:23682121   PMID:23813214   PMID:24896321  
PMID:24943643   PMID:25187353   PMID:25354767   PMID:25429616   PMID:25661317   PMID:25725289   PMID:26154847   PMID:26213104   PMID:26317759   PMID:26760575   PMID:26810542   PMID:27038930  
PMID:27134041   PMID:27333659   PMID:27683013   PMID:27683014   PMID:27987235   PMID:28235198   PMID:28298427   PMID:28373571   PMID:28441750   PMID:28446460   PMID:28789481   PMID:28882563  
PMID:29524036   PMID:29925945   PMID:30012607   PMID:30365112   PMID:30633335   PMID:32183950   PMID:32817461  


Genomics

Comparative Map Data
ADORA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1203,090,654 - 203,167,405 (+)EnsemblGRCh38hg38GRCh38
GRCh381203,127,705 - 203,167,405 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371203,096,854 - 203,136,533 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh371203,096,833 - 203,136,533 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,363,459 - 201,403,156 (+)NCBINCBI36hg18NCBI36
Build 341199,791,438 - 199,868,189NCBI
Celera1176,226,082 - 176,265,774 (+)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1174,262,408 - 174,301,662 (+)NCBIHuRef
CHM1_11204,519,171 - 204,558,852 (+)NCBICHM1_1
Adora1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,126,953 - 134,163,195 (-)NCBIGRCm39mm39
GRCm381134,199,215 - 134,235,457 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,199,223 - 134,235,431 (-)EnsemblGRCm38mm10GRCm38
MGSCv371136,095,799 - 136,132,008 (-)NCBIGRCm37mm9NCBIm37
MGSCv361136,015,633 - 136,051,842 (-)NCBImm8
Celera1136,811,737 - 136,847,932 (-)NCBICelera
Cytogenetic Map1E4NCBI
Adora1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21345,658,872 - 45,695,821 (-)NCBI
Rnor_6.0 Ensembl1351,042,248 - 51,076,852 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01351,042,111 - 51,076,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01356,097,883 - 56,132,155 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,160,292 - 47,192,804 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11347,173,084 - 47,207,198 (-)NCBI
Celera1345,990,556 - 46,022,753 (-)NCBICelera
Cytogenetic Map13q13NCBI
Adora1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540639,149,689 - 39,187,688 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540639,148,811 - 39,183,577 (+)NCBIChiLan1.0ChiLan1.0
ADORA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11183,023,466 - 183,063,760 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1183,023,466 - 183,063,760 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01178,728,751 - 178,769,066 (+)NCBIMhudiblu_PPA_v0panPan3
ADORA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl744,820 - 73,051 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1744,819 - 74,217 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Adora1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365671,430,128 - 1,508,626 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADORA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9113,835,920 - 113,875,719 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19113,835,279 - 113,875,899 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29125,293,656 - 125,331,581 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADORA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12526,180,898 - 26,221,424 (-)NCBI
ChlSab1.1 Ensembl2526,182,446 - 26,220,776 (-)Ensembl
Adora1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248077,674,164 - 7,705,736 (-)NCBI

Position Markers
GDB:452605  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371203,135,068 - 203,135,219UniSTSGRCh37
Build 361201,401,691 - 201,401,842RGDNCBI36
Celera1176,264,309 - 176,264,460RGD
Cytogenetic Map1q32.1UniSTS
HuRef1174,300,198 - 174,300,349UniSTS
D1S1699  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371203,097,548 - 203,097,823UniSTSGRCh37
Build 361201,364,171 - 201,364,446RGDNCBI36
Celera1176,226,794 - 176,227,069RGD
Cytogenetic Map1q32.1UniSTS
HuRef1174,263,118 - 174,263,393UniSTS
Whitehead-YAC Contig Map1 UniSTS
SHGC-76157  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371203,136,421 - 203,136,529UniSTSGRCh37
Build 361201,403,044 - 201,403,152RGDNCBI36
Celera1176,265,662 - 176,265,770RGD
Cytogenetic Map1q32.1UniSTS
HuRef1174,301,550 - 174,301,658UniSTS
TNG Radiation Hybrid Map133690.0UniSTS
GeneMap99-GB4 RH Map1666.51UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5187
Count of miRNA genes:895
Interacting mature miRNAs:1098
Transcripts:ENST00000309502, ENST00000337894, ENST00000367235, ENST00000367236, ENST00000464019, ENST00000467253, ENST00000472535
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 18 112 55 11 53 11 183 13 2602 84 472 90 56 85 1
Low 1573 1306 1064 249 461 95 3158 1552 915 261 648 1424 162 1098 1870 2
Below cutoff 816 1441 569 335 928 330 1006 619 206 67 325 69 10 1 50 832 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_052917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001048230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001365065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001365066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005244901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005244902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB004662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC105940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK127752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY136746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU740906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA343445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB171678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF057066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GM047589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC881108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC884744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L22214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S45235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S56143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X68485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000309502   ⟹   ENSP00000308549
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1203,090,654 - 203,167,404 (+)Ensembl
RefSeq Acc Id: ENST00000337894   ⟹   ENSP00000338435
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1203,127,726 - 203,167,405 (+)Ensembl
RefSeq Acc Id: ENST00000367235   ⟹   ENSP00000356204
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1203,128,306 - 203,166,749 (+)Ensembl
RefSeq Acc Id: ENST00000367236   ⟹   ENSP00000356205
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1203,127,065 - 203,167,405 (+)Ensembl
RefSeq Acc Id: ENST00000464019
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1203,129,634 - 203,165,741 (+)Ensembl
RefSeq Acc Id: ENST00000467253
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1203,152,646 - 203,166,115 (+)Ensembl
RefSeq Acc Id: ENST00000472535
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1203,150,632 - 203,166,749 (+)Ensembl
RefSeq Acc Id: ENST00000618295   ⟹   ENSP00000483953
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1203,128,373 - 203,166,062 (+)Ensembl
RefSeq Acc Id: ENST00000640524   ⟹   ENSP00000491900
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1203,127,708 - 203,165,089 (+)Ensembl
RefSeq Acc Id: NM_000674   ⟹   NP_000665
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,127,726 - 203,167,405 (+)NCBI
GRCh371203,096,833 - 203,136,533 (+)NCBI
Build 361201,363,459 - 201,403,156 (+)NCBI Archive
HuRef1174,262,408 - 174,301,662 (+)ENTREZGENE
CHM1_11204,519,171 - 204,558,852 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001048230   ⟹   NP_001041695
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,127,726 - 203,167,405 (+)NCBI
GRCh371203,096,833 - 203,136,533 (+)NCBI
Build 361201,363,459 - 201,403,156 (+)NCBI Archive
HuRef1174,262,408 - 174,301,662 (+)ENTREZGENE
CHM1_11204,519,171 - 204,558,852 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001365065   ⟹   NP_001351994
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,127,726 - 203,167,405 (+)NCBI
RefSeq Acc Id: NM_001365066   ⟹   NP_001351995
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,127,726 - 203,167,405 (+)NCBI
RefSeq Acc Id: XM_005244901   ⟹   XP_005244958
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,127,705 - 203,167,405 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005244902   ⟹   XP_005244959
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,128,914 - 203,167,405 (+)NCBI
GRCh371203,096,833 - 203,136,533 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000665   ⟸   NM_000674
- Peptide Label: isoform 1
- UniProtKB: P30542 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001041695   ⟸   NM_001048230
- Peptide Label: isoform 1
- UniProtKB: P30542 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005244958   ⟸   XM_005244901
- Peptide Label: isoform X1
- UniProtKB: B7Z1L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005244959   ⟸   XM_005244902
- Peptide Label: isoform X1
- UniProtKB: B7Z1L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001351995   ⟸   NM_001365066
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001351994   ⟸   NM_001365065
- Peptide Label: isoform 2
RefSeq Acc Id: ENSP00000308549   ⟸   ENST00000309502
RefSeq Acc Id: ENSP00000338435   ⟸   ENST00000337894
RefSeq Acc Id: ENSP00000491900   ⟸   ENST00000640524
RefSeq Acc Id: ENSP00000356205   ⟸   ENST00000367236
RefSeq Acc Id: ENSP00000356204   ⟸   ENST00000367235
RefSeq Acc Id: ENSP00000483953   ⟸   ENST00000618295
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:6858618
Promoter ID:EPDNEW_H2474
Type:initiation region
Name:ADORA1_3
Description:adenosine A1 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2475  EPDNEW_H2476  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,127,139 - 203,127,199EPDNEW
RGD ID:6858620
Promoter ID:EPDNEW_H2475
Type:initiation region
Name:ADORA1_2
Description:adenosine A1 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2474  EPDNEW_H2476  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,127,751 - 203,127,811EPDNEW
RGD ID:6858622
Promoter ID:EPDNEW_H2476
Type:initiation region
Name:ADORA1_1
Description:adenosine A1 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2474  EPDNEW_H2475  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,128,300 - 203,128,360EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11
pathogenic
GRCh37/hg19 1q31.3-42.13(chr1:197811907-228997888)x3 copy number gain See cases [RCV000240137] Chr1:197811907..228997888 [GRCh37]
Chr1:1q31.3-42.13
pathogenic
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44
pathogenic
NM_000674.3(ADORA1):c.835G>A (p.Gly279Ser) single nucleotide variant not provided [RCV000417207] Chr1:203165754 [GRCh38]
Chr1:203134882 [GRCh37]
Chr1:1q32.1
uncertain significance
GRCh37/hg19 1q32.1(chr1:203134126-203160335)x3 copy number gain See cases [RCV000448399] Chr1:203134126..203160335 [GRCh37]
Chr1:1q32.1
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41
pathogenic
GRCh37/hg19 1q32.1(chr1:202542202-203108963)x3 copy number gain not provided [RCV000749330] Chr1:202542202..203108963 [GRCh37]
Chr1:1q32.1
benign
NM_000674.3(ADORA1):c.157G>A (p.Val53Met) single nucleotide variant not provided [RCV000899644] Chr1:203128998 [GRCh38]
Chr1:203098126 [GRCh37]
Chr1:1q32.1
likely benign
NM_000674.3(ADORA1):c.831G>A (p.Thr277=) single nucleotide variant not provided [RCV000926454] Chr1:203165750 [GRCh38]
Chr1:203134878 [GRCh37]
Chr1:1q32.1
likely benign
NM_000674.3(ADORA1):c.585C>T (p.Leu195=) single nucleotide variant not provided [RCV000895957] Chr1:203165504 [GRCh38]
Chr1:203134632 [GRCh37]
Chr1:1q32.1
benign
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44
pathogenic
GRCh37/hg19 1q31.3-32.2(chr1:194356425-210988710)x3 copy number gain not provided [RCV001249273] Chr1:194356425..210988710 [GRCh37]
Chr1:1q31.3-32.2
not provided
NM_000674.3(ADORA1):c.342-4C>G single nucleotide variant not provided [RCV000901514] Chr1:203165257 [GRCh38]
Chr1:203134385 [GRCh37]
Chr1:1q32.1
likely benign
NM_000674.3(ADORA1):c.6G>A (p.Pro2=) single nucleotide variant not provided [RCV000888903] Chr1:203128847 [GRCh38]
Chr1:203097975 [GRCh37]
Chr1:1q32.1
benign
NM_000674.3(ADORA1):c.117G>A (p.Ala39=) single nucleotide variant not provided [RCV000954850] Chr1:203128958 [GRCh38]
Chr1:203098086 [GRCh37]
Chr1:1q32.1
likely benign
NM_000674.3(ADORA1):c.513C>T (p.Phe171=) single nucleotide variant not provided [RCV000932259] Chr1:203165432 [GRCh38]
Chr1:203134560 [GRCh37]
Chr1:1q32.1
likely benign
GRCh37/hg19 1q32.1(chr1:203078722-203210585)x1 copy number loss not provided [RCV001005167] Chr1:203078722..203210585 [GRCh37]
Chr1:1q32.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:262 AgrOrtholog
COSMIC ADORA1 COSMIC
Ensembl Genes ENSG00000163485 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000308549 UniProtKB/Swiss-Prot
  ENSP00000338435 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000356204 UniProtKB/Swiss-Prot
  ENSP00000356205 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000483953 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000491900 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000309502 UniProtKB/Swiss-Prot
  ENST00000337894 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000367235 UniProtKB/Swiss-Prot
  ENST00000367236 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000618295 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000640524 UniProtKB/Swiss-Prot
GTEx ENSG00000163485 GTEx
HGNC ID HGNC:262 ENTREZGENE
Human Proteome Map ADORA1 Human Proteome Map
InterPro Adeno_A1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenosn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:134 UniProtKB/Swiss-Prot
NCBI Gene 134 ENTREZGENE
OMIM 102775 OMIM
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADORA1 RGD, PharmGKB
PRINTS ADENOSINEA1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADENOSINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt A0A087X173_HUMAN UniProtKB/TrEMBL
  AA1R_HUMAN UniProtKB/Swiss-Prot
  B7Z1L9 ENTREZGENE, UniProtKB/TrEMBL
  P30542 ENTREZGENE
  S5RC53_HUMAN UniProtKB/TrEMBL
UniProt Secondary A6NFY5 UniProtKB/Swiss-Prot
  A6NGP4 UniProtKB/Swiss-Prot
  A8K1L3 UniProtKB/Swiss-Prot
  B3KXQ4 UniProtKB/Swiss-Prot
  D2CGD0 UniProtKB/Swiss-Prot
  Q6FHK3 UniProtKB/Swiss-Prot
  Q8TAM8 UniProtKB/Swiss-Prot