Hspa8 (heat shock protein family A (Hsp70) member 8) - Rat Genome Database

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Gene: Hspa8 (heat shock protein family A (Hsp70) member 8) Rattus norvegicus
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Symbol: Hspa8
Name: heat shock protein family A (Hsp70) member 8
RGD ID: 621725
Description: Exhibits several functions, including A1 adenosine receptor binding activity; adenyl ribonucleotide binding activity; and clathrin-uncoating ATPase activity. Involved in several processes, including animal organ development; protein transport; and protein-containing complex disassembly. Localizes to several cellular components, including polymeric cytoskeletal fiber; region of cytosol; and vacuole. Biomarker of Parkinson's disease; acute kidney failure; brain ischemia; disease of metabolism; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8); PARTICIPATES IN androgen signaling pathway; chaperone mediated autophagy pathway; clathrin-dependent synaptic vesicle endocytosis; INTERACTS WITH (+)-schisandrin B; (R)-adrenaline; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: heat shock 70 kDa protein 8; heat shock 70kD protein 8; heat shock 70kDa protein 8; heat shock cognate 71 kDa protein; Heat shock cognate protein 70; heat shock protein 8; heat shock protein A8; Hsc70; MGC114311
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Hspa8-ps1   LOC100363133  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: The functional gene for Hspa8 is located on Rno8. It was incorrectly placed on Rno5 on the reference assembly for NCBI Build 4.1 at the location of one of its pseudogenes. The correct GeneID for the pseudogene is geneID:100190885. [17 Jun 2014]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2841,183,397 - 41,187,260 (+)NCBI
Rnor_6.0 Ensembl844,990,014 - 44,993,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0844,989,401 - 44,993,261 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0843,478,238 - 43,480,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0846,005,304 - 46,006,864 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4843,784,035 - 43,787,760 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1843,792,829 - 43,796,525 (+)NCBI
Celera840,782,916 - 40,786,778 (+)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(R)-adrenaline  (EXP)
(S)-amphetamine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
7H-xanthine  (EXP)
8-Br-cAMP  (ISO)
9H-xanthine  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
albendazole  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (EXP)
alpha-pinene  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
apigenin  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
atrazine  (ISO)
bathocuproine disulfonic acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
casticin  (ISO)
ceruletide  (EXP)
chloromethylisothiazolinone  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
dihydroartemisinin  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
formetanate  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
gamma-poly(L-glutamic acid) macromolecule  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hyaluronic acid  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroxyurea  (ISO)
ibuprofen  (ISO)
imipramine  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
iodide salt  (EXP)
ionomycin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isobutanol  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lovastatin  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mercury dichloride  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methomyl  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (ISO)
microcystin-LR  (ISO)
mitomycin C  (ISO)
monocrotaline  (ISO)
morphine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylformamide  (ISO)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
nimesulide  (EXP)
nitric oxide  (EXP)
nitrofurantoin  (EXP)
ochratoxin A  (EXP)
oxidopamine  (EXP,ISO)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
PhIP  (EXP)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
pirimicarb  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propiconazole  (ISO)
Propiverine  (EXP)
prostaglandin A1  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
quinolin-8-ol  (ISO)
quizartinib  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
sarin  (EXP)
sertraline  (EXP,ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
T-2 toxin  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
thiostrepton  (ISO)
titanium dioxide  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP,ISO)
triphenylstannane  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
warfarin  (ISO)
Yessotoxin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
ATP metabolic process  (ISO)
axo-dendritic transport  (IEP)
cellular protein complex disassembly  (IMP)
cellular response to cadmium ion  (IEP)
cellular response to heat  (IEP)
cellular response to unfolded protein  (IBA)
cerebellum development  (IEP)
chaperone cofactor-dependent protein refolding  (IBA,ISO)
chaperone-mediated autophagy  (IDA)
chaperone-mediated autophagy translocation complex disassembly  (IBA,IDA)
chaperone-mediated protein folding  (IDA,ISO)
clathrin coat disassembly  (IDA,ISO)
estrous cycle  (IEP)
forebrain development  (IEP)
G1/S transition of mitotic cell cycle  (IEP)
kidney development  (IEP)
late endosomal microautophagy  (IBA,ISO)
maintenance of postsynaptic specialization structure  (EXP,IDA,IMP)
modulation by host of viral process  (ISO)
mRNA processing  (IEA)
negative regulation of cardiac muscle cell apoptotic process  (IMP)
negative regulation of hydrogen peroxide-induced cell death  (IEP)
negative regulation of supramolecular fiber organization  (ISO)
negative regulation of transcription, DNA-templated  (ISO,ISS)
obsolete chaperone-mediated protein transport involved in chaperone-mediated autophagy  (IBA,IGI)
positive regulation by host of viral genome replication  (ISO)
positive regulation of catalytic activity  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of lysosomal membrane permeability  (IMP)
positive regulation of mRNA splicing, via spliceosome  (ISO)
positive regulation of phagocytosis  (IMP)
positive regulation of protein refolding  (IDA)
positive regulation of proteolysis  (IDA)
positive regulation of T cell mediated cytotoxicity  (IMP)
protein autophosphorylation  (IDA)
protein folding  (ISO)
protein import into nucleus  (IMP)
protein refolding  (IBA,ISO,ISS)
protein targeting to lysosome involved in chaperone-mediated autophagy  (IBA,ISO)
protein transmembrane import into intracellular organelle  (IEP)
regulation of cell cycle  (ISO)
regulation of postsynapse organization  (ISO)
regulation of protein complex stability  (IDA)
regulation of protein stability  (ISO)
response to activity  (IEP)
response to drug  (IEP)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to heat  (IEP)
response to nickel cation  (IEP)
response to odorant  (IEP)
response to progesterone  (IEP)
response to starvation  (IEP)
RNA splicing  (IEA)
sensory perception of smell  (IEP)
skeletal muscle tissue development  (IEP)
slow axonal transport  (IBA,IEP)
synaptic vesicle uncoating  (IC)
vesicle-mediated transport  (IBA)

References

References - curated
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Additional References at PubMed
PMID:8535066   PMID:9122205   PMID:9920933   PMID:10373374   PMID:10567422   PMID:10722728   PMID:11891788   PMID:12150907   PMID:12426384   PMID:12477932   PMID:12588994   PMID:12773536  
PMID:12878599   PMID:14627652   PMID:14644449   PMID:14681019   PMID:14978028   PMID:15215316   PMID:15489334   PMID:15543931   PMID:15972823   PMID:16207813   PMID:16502470   PMID:16854843  
PMID:16903783   PMID:16906134   PMID:17182002   PMID:17289661   PMID:17441507   PMID:17634366   PMID:17636261   PMID:17979815   PMID:18310515   PMID:18378183   PMID:19028452   PMID:19056867  
PMID:19199708   PMID:19388598   PMID:19551494   PMID:19724054   PMID:19946888   PMID:20160091   PMID:20176811   PMID:20458337   PMID:20884878   PMID:21151134   PMID:21231916   PMID:21235781  
PMID:21238931   PMID:21362503   PMID:21423176   PMID:21423662   PMID:21482805   PMID:21697503   PMID:21811788   PMID:22082260   PMID:22206666   PMID:22516433   PMID:22658674   PMID:22681889  
PMID:22871113   PMID:23106098   PMID:23376485   PMID:23533145   PMID:23636947   PMID:23762333   PMID:23904609   PMID:23921388   PMID:23979707   PMID:24030972   PMID:24616664   PMID:24625528  
PMID:25281747   PMID:25468996   PMID:25719862   PMID:25891763   PMID:26212789   PMID:26316108   PMID:26323693   PMID:26581985   PMID:27365397   PMID:28234934   PMID:28559423   PMID:29339092  
PMID:29476059   PMID:29875314   PMID:31506297   PMID:31904090   PMID:32336545  


Genomics

Comparative Map Data
Hspa8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2841,183,397 - 41,187,260 (+)NCBI
Rnor_6.0 Ensembl844,990,014 - 44,993,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0844,989,401 - 44,993,261 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0843,478,238 - 43,480,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0846,005,304 - 46,006,864 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4843,784,035 - 43,787,760 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1843,792,829 - 43,796,525 (+)NCBI
Celera840,782,916 - 40,786,778 (+)NCBICelera
Cytogenetic Map8q22NCBI
HSPA8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11123,057,489 - 123,063,230 (-)EnsemblGRCh38hg38GRCh38
GRCh3811123,057,489 - 123,062,366 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711122,928,197 - 122,932,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611122,433,410 - 122,438,054 (-)NCBINCBI36hg18NCBI36
Build 3411122,433,410 - 122,438,054NCBI
Celera11120,087,529 - 120,092,173 (-)NCBI
Cytogenetic Map11q24.1NCBI
HuRef11118,870,278 - 118,875,122 (-)NCBIHuRef
CHM1_111122,814,192 - 122,819,035 (-)NCBICHM1_1
Hspa8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39940,712,572 - 40,716,498 (+)NCBIGRCm39mm39
GRCm39 Ensembl940,712,280 - 40,721,383 (+)Ensembl
GRCm38940,801,276 - 40,805,202 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl940,800,984 - 40,810,087 (+)EnsemblGRCm38mm10GRCm38
MGSCv37940,609,356 - 40,613,282 (+)NCBIGRCm37mm9NCBIm37
MGSCv3658,102,053 - 8,104,168 (+)NCBImm8
MGSCv36940,552,355 - 40,556,269 (+)NCBImm8
Celera938,034,609 - 38,038,251 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map921.55NCBI
Hspa8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541223,862,590 - 23,867,984 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541223,863,513 - 23,867,984 (-)NCBIChiLan1.0ChiLan1.0
HSPA8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111121,809,800 - 121,814,628 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11121,809,800 - 121,815,773 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011117,890,545 - 117,895,262 (-)NCBIMhudiblu_PPA_v0panPan3
HSPA8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1511,292,219 - 11,296,851 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl511,292,262 - 11,296,797 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha511,348,073 - 11,352,702 (+)NCBI
ROS_Cfam_1.0511,243,037 - 11,247,671 (+)NCBI
UMICH_Zoey_3.1511,346,458 - 11,351,078 (+)NCBI
UNSW_CanFamBas_1.0511,279,270 - 11,283,884 (+)NCBI
UU_Cfam_GSD_1.0511,323,539 - 11,328,166 (+)NCBI
Hspa8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947104,655,786 - 104,660,238 (-)NCBI
SpeTri2.0NW_0049365427,577,192 - 7,581,598 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl949,982,284 - 49,990,508 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1949,982,278 - 49,986,760 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2955,405,395 - 55,409,839 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSPA8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11114,447,348 - 114,452,693 (-)NCBI
ChlSab1.1 Ensembl1114,446,544 - 114,451,562 (-)Ensembl
Hspa8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248802,070,410 - 2,075,069 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8210812847108128Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8210812847108128Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8210812847108128Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8210812847108128Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8736807652368076Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8736807652368076Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8736807652368076Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8873867753738677Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)89531047119211942Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)81038843955388439Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)81038843955388439Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810938911120496129Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81137326757541668Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81137350945712344Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81137350945712344Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81144825156448251Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81144825156448251Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81766655562666555Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)82071759265717592Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)82146491991140553Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)821813070100873963Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82784149672841496Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82816802350708951Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82986798359908353Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)829867983106526740Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)829867983106526740Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)829867983106526740Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83014480075144800Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)83014480075144800Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)83091811258858224Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)83091811275918112Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)830918112107206309Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83220198154065241Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83220198175971421Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)832888352101374135Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866046588570Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866062857995Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866065717592Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866065717592Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83355866065717592Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83355866065717592Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866065717592Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83355866065717592Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83355866089058369Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83355866089058369Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83355866089058369Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83355866089058369Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)833558660109028082Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)833558660109028082Rat
1578755Pur5Proteinuria QTL 53.30.0001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)833558660109028082Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)833558764113580387Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83504141480041414Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83592559480925594Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)839230130106506973Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83992790184927901Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83995802284958022Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84421919789542960Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)844219197100873963Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)844458129118087517Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:77
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000013159, ENSRNOT00000041306, ENSRNOT00000044608
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 8 8 8 12 13 4 1
Medium 2 43 49 33 19 33 8 11 62 22 37 10 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC061547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000044608   ⟹   ENSRNOP00000042159
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl844,990,014 - 44,993,179 (+)Ensembl
RefSeq Acc Id: NM_024351   ⟹   NP_077327
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2841,183,397 - 41,187,260 (+)NCBI
Rnor_6.0844,989,401 - 44,993,261 (+)NCBI
Rnor_5.0843,478,238 - 43,480,456 (+)NCBI
Rnor_5.0846,005,304 - 46,006,864 (-)NCBI
RGSC_v3.4843,784,035 - 43,787,760 (+)RGD
Celera840,782,916 - 40,786,778 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_077327   ⟸   NM_024351
- UniProtKB: P63018 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000042159   ⟸   ENSRNOT00000044608

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621725 AgrOrtholog
Ensembl Genes ENSRNOG00000034066 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000042159 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044608 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.34.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24468 UniProtKB/Swiss-Prot
NCBI Gene 24468 ENTREZGENE
PANTHER PTHR19375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hspa8 PhenoGen
PROSITE HSP70_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D4A4S3_RAT UniProtKB/TrEMBL
  HSP7C_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P08109 UniProtKB/Swiss-Prot
  P12225 UniProtKB/Swiss-Prot
  Q4FZY7 UniProtKB/Swiss-Prot
  Q62373 UniProtKB/Swiss-Prot
  Q62374 UniProtKB/Swiss-Prot
  Q62375 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Hspa8  heat shock protein family A (Hsp70) member 8  Hspa8  heat shock 70kDa protein 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-06-04 Hspa8  heat shock 70kDa protein 8  Hspa8  heat shock protein 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-29 Hspa8  heat shock protein 8  Hspa8  heat shock protein A8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-06 Hspa8  heat shock protein A8  Hspa8  heat shock protein 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Hspa8  heat shock protein 8      Symbol and Name updated 629477 APPROVED
2003-03-12 Hspa8  heat shock protein 8  Hsc70  Heat shock cognate protein 70  Data Merged 628472 PROVISIONAL
2003-03-12   heat shock protein 8  Hspa8  heat shock 70kD protein 8  Name updated to reflect Human and Mouse nomenclature 61478 PROVISIONAL
2002-11-06 Hspa8  heat shock 70kD protein 8      Symbol and Name updated 625702 APPROVED
2002-08-07 Hspa8        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Hsc70  Heat shock cognate protein 70      Symbol and Name status set to approved 70586 APPROVED