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Gene: Hspa8 (heat shock protein family A (Hsp70) member 8) Rattus norvegicus
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Symbol: Hspa8
Name: heat shock protein family A (Hsp70) member 8
Description: Exhibits several functions, including A1 adenosine receptor binding activity; adenyl ribonucleotide binding activity; and clathrin-uncoating ATPase activity. Involved in several processes, including animal organ development; negative regulation of cell death; and protein transport. Localizes to several cellular components, including dendrite; polymeric cytoskeletal fiber; and vacuole. Biomarker of Parkinson's disease; acute kidney failure; brain ischemia; disease of metabolism; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8); PARTICIPATES IN androgen signaling pathway; chaperone mediated autophagy pathway; clathrin-dependent synaptic vesicle endocytosis; INTERACTS WITH (+)-schisandrin B; (R)-adrenaline; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: heat shock 70 kDa protein 8; heat shock 70kD protein 8; heat shock 70kDa protein 8; heat shock cognate 71 kDa protein; Heat shock cognate protein 70; heat shock protein 8; heat shock protein A8; Hsc70; MGC114311
Orthologs:
Homo sapiens (human) : HSPA8 (heat shock protein family A (Hsp70) member 8)  HGNC  Alliance
Mus musculus (house mouse) : Hspa8 (heat shock protein 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspa8 (heat shock protein family A (Hsp70) member 8)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPA8 (heat shock protein family A (Hsp70) member 8)
Canis lupus familiaris (dog) : HSPA8 (heat shock protein family A (Hsp70) member 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspa8 (heat shock protein family A (Hsp70) member 8)
Sus scrofa (pig) : HSPA8 (heat shock protein family A (Hsp70) member 8)
Chlorocebus sabaeus (African green monkey) : HSPA8 (heat shock protein family A (Hsp70) member 8)
Heterocephalus glaber (naked mole-rat) : Hspa8 (heat shock protein family A (Hsp70) member 8)
more info ...
Related Pseudogenes: Hspa8-ps1   LOC100363133  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: The functional gene for Hspa8 is located on Rno8. It was incorrectly placed on Rno5 on the reference assembly for NCBI Build 4.1 at the location of one of its pseudogenes. The correct GeneID for the pseudogene is geneID:100190885. [17 Jun 2014]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0844,989,401 - 44,993,261 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl844,990,014 - 44,993,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0846,005,304 - 46,006,864 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0843,478,238 - 43,480,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4843,784,035 - 43,787,760 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1843,792,829 - 43,796,525 (+)NCBI
Celera840,782,916 - 40,786,778 (+)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Hspa8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621725
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.