Vdr (vitamin D receptor) - Rat Genome Database

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Gene: Vdr (vitamin D receptor) Rattus norvegicus
Analyze
Symbol: Vdr
Name: vitamin D receptor
RGD ID: 3959
Description: Enables calcitriol binding activity; nuclear receptor activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of bone trabecula formation; and positive regulation of parathyroid hormone secretion. Located in several cellular components, including T-tubule; chromatin; and nuclear lumen. Colocalizes with caveola. Used to study vitamin D-dependent rickets type 2A. Biomarker of secondary hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); lipid storage disease (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to human VDR (vitamin D receptor); PARTICIPATES IN altered p53 signaling pathway; tuberculosis pathway; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1,25-dihydroxyvitamin D3 receptor; Nr1i1; nuclear receptor subfamily 1 group I member 1; vitamin D (1,25- dihydroxyvitamin D3) receptor; Vitamin D (1,25-dihydroxyvitamin D3) receptor; Vitamin D (125-dihydroxyvitamin D3) receptor; vitamin D3 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Vdrem1Thka   Vdrem2Thka  
Genetic Models: W-Vdrem1Thka W-Vdrem2Thka
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27128,987,981 - 129,037,677 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7128,987,981 - 129,037,677 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7130,785,124 - 130,834,890 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07133,010,661 - 133,060,429 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07132,923,119 - 132,972,888 (-)NCBIRnor_WKY
Rnor_6.07139,344,452 - 139,394,138 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,342,063 - 139,394,166 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,536,241 - 139,585,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47136,567,614 - 136,617,280 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17136,644,050 - 136,693,717 (-)NCBI
Celera7125,479,125 - 125,528,679 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
Acute Hepatitis  (ISO)
Addison's disease  (ISO)
alopecia  (ISO)
amyotrophic lateral sclerosis  (ISO)
aortic valve stenosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autism spectrum disorder  (ISO)
autoimmune hepatitis  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2B  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Barrett's esophagus  (ISO)
basal cell carcinoma  (ISO)
Behcet's disease  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchopulmonary Dysplasia  (ISO)
cholangitis  (ISO)
Chronic Hepatitis C  (ISO)
Chronic Periodontitis  (ISO)
coronary artery disease  (ISO)
Crohn's disease  (ISO)
diabetes mellitus  (ISO)
diabetic retinopathy  (ISO)
disease of cellular proliferation  (ISO)
Dwarfism  (ISO)
erythema nodosum  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Fabry disease  (ISO)
familial adenomatous polyposis 2  (ISO)
Familial Hypophosphatemic Rickets  (ISO)
fatty liver disease  (ISO)
Fetal Growth Retardation  (ISO)
genetic disease  (ISO)
Graves' disease  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hypercalciuria  (IEP)
hypertension  (ISO)
Hypophosphatemic Rickets  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Intervertebral Disc Displacement  (ISO)
Knee Osteoarthritis  (ISO)
Lead Poisoning  (ISO)
leishmaniasis  (ISO)
lepromatous leprosy  (ISO)
liver cirrhosis  (ISO)
male breast cancer  (ISO)
melanoma  (ISO)
multiple sclerosis  (ISO)
Myocardial Reperfusion Injury  (ISO)
myopia  (ISO)
Neoplasm Metastasis  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
osteoporosis  (ISO,ISS)
otosclerosis  (ISO)
Parathyroid Neoplasms  (ISO)
Parkinson's disease  (ISO)
peptic esophagitis  (ISO)
periodontitis  (ISO)
pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
primary biliary cholangitis  (ISO)
primary hyperparathyroidism  (ISO)
primary sclerosing cholangitis  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
rickets  (ISO)
secondary hyperparathyroidism  (IEP)
skin melanoma  (ISO)
Spinal Fractures  (ISO)
squamous cell carcinoma  (ISO)
Sunburn  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
temporal lobe epilepsy  (ISO)
transitional cell carcinoma  (ISO)
tuberculoid leprosy  (ISO)
tuberculosis  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
Urinary Calculi  (ISO)
Viral Bronchiolitis  (ISO)
Vitamin D Deficiency  (ISO)
vitamin D-dependent rickets  (ISO)
vitamin D-dependent rickets type 2A  (IMP,ISO)
vitiligo  (ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(R)-noradrenaline  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methoxytyramine  (ISO)
3-oxo-5beta-cholanic acid  (ISO)
3-phenoxybenzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP)
alendronic acid  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
alpha-linolenic acid  (ISO)
alpha-naphthoflavone  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
bafilomycin A1  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bezafibrate  (ISO)
biphenyl-2-ol  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcidiol  (ISO)
calciol  (EXP,ISO)
calcipotriol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
captopril  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
cefalotin  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (EXP,ISO)
CHIR 99021  (EXP)
chloroacetaldehyde  (ISO)
cholanic acid  (ISO)
cholesterol  (ISO)
cholic acid  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (EXP)
daunorubicin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
estriol  (ISO)
etoposide  (ISO)
eugenol  (ISO)
Falecalcitriol  (ISO)
fenvalerate  (EXP)
flucythrinate  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gamma-tocopherol  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP)
glycitein  (ISO)
Goe 6976  (ISO)
guggulsterone  (ISO)
GW 501516  (ISO)
hexachlorobenzene  (ISO)
homovanillic acid  (ISO)
idarubicin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isopentenyl diphosphate  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
lacidipine  (ISO)
lactacystin  (ISO)
lamivudine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP,ISO)
LY294002  (ISO)
manidipine  (ISO)
Maxacalcitol  (ISO)
medroxyprogesterone acetate  (ISO)
mercaptopurine  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methyl beta-cyclodextrin  (ISO)
methylseleninic acid  (ISO)
N-nitrosodiethylamine  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
paricalcitol  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenothrin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
prednisone  (ISO)
promegestone  (ISO)
propanal  (ISO)
purine-6-thiol  (ISO)
pyridaben  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
saracatinib  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sotorasib  (ISO)
staurosporine  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
superoxide  (ISO)
suramin  (ISO)
tamoxifen  (EXP,ISO)
terbufos  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
trametinib  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
uranium atom  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vitamin D  (EXP,ISO)
warfarin  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
animal organ morphogenesis  (ISO)
apoptotic process involved in mammary gland involution  (IEA,ISO)
apoptotic signaling pathway  (IDA)
bile acid signaling pathway  (IEA,ISO)
calcium ion transport  (IEA,ISO)
cell differentiation  (IBA)
cell morphogenesis  (IEA,ISO)
cellular response to amyloid-beta  (IEP)
cellular response to vitamin D  (IEP)
decidualization  (IEA,ISO)
DNA-templated transcription  (ISO)
heart development  (IEP)
intestinal absorption  (IEA,ISO)
intracellular calcium ion homeostasis  (IEA,ISO)
intracellular receptor signaling pathway  (ISO)
lactation  (IEA,ISO)
mammary gland branching involved in pregnancy  (IEA,ISO)
mRNA transcription by RNA polymerase II  (IEA,ISO)
negative regulation of bone trabecula formation  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of keratinocyte proliferation  (IEA,ISO)
negative regulation of ossification  (IMP)
negative regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
positive regulation of apoptotic process involved in mammary gland involution  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of keratinocyte differentiation  (IEA,ISO)
positive regulation of parathyroid hormone secretion  (IMP)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
positive regulation of vitamin D 24-hydroxylase activity  (IEA,ISO)
positive regulation of vitamin D receptor signaling pathway  (IEA,ISO)
regulation of calcidiol 1-monooxygenase activity  (IEA,ISO)
regulation of calcium ion transport  (IDA)
regulation of DNA-templated transcription  (ISO)
regulation of transcription by RNA polymerase II  (ISO,TAS)
response to calcium ion  (IEP)
response to estradiol  (IEP)
skeletal system development  (IEA,ISO)
vitamin D receptor signaling pathway  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer risk. Abbas S, etal., Breast Cancer Res. 2008;10(2):R31. doi: 10.1186/bcr1994. Epub 2008 Apr 17.
2. Vitamin D receptor gene methylation in hepatocellular carcinoma. Abdalla M, etal., Gene. 2018 May 5;653:65-71. doi: 10.1016/j.gene.2018.02.024. Epub 2018 Feb 9.
3. Vitamin D receptor (VDR) gene SNPs influence VDR expression and modulate protection from multiple sclerosis in HLA-DRB1*15-positive individuals. Agliardi C, etal., Brain Behav Immun. 2011 Jun 12.
4. MicroRNA signatures predict dysregulated vitamin D receptor and calcium pathways status in limb girdle muscle dystrophies (LGMD) 2A/2B. Aguennouz M, etal., Cell Biochem Funct. 2016 Aug;34(6):414-22. doi: 10.1002/cbf.3202.
5. Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk. Ahn J, etal., Carcinogenesis. 2009 May;30(5):769-76. Epub 2009 Mar 2.
6. The Association of Vitamin D Receptor Polymorphisms with Multiple Sclerosis in a Case-Control Study from Kuwait. Al-Temaimi RA, etal., PLoS One. 2015 Nov 5;10(11):e0142265. doi: 10.1371/journal.pone.0142265. eCollection 2015.
7. 5' regulatory and 3' untranslated region polymorphisms of vitamin D receptor gene in south Indian HIV and HIV-TB patients. Alagarasu K, etal., J Clin Immunol. 2009 Mar;29(2):196-204. Epub 2008 Aug 20.
8. Association of vitamin D receptor gene start codon (Fok1) polymorphism with high myopia. Annamaneni S, etal., Oman J Ophthalmol. 2011 May;4(2):57-62. doi: 10.4103/0974-620X.83654.
9. Association of vitamin D levels and vitamin D-related gene polymorphisms with liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease. Arai T, etal., Dig Liver Dis. 2019 Jan 9. pii: S1590-8658(19)30003-9. doi: 10.1016/j.dld.2018.12.022.
10. Analysis of vitamin D receptor gene polymorphisms in vitiligo. Aydingoz IE, etal., Dermatology. 2012;224(4):361-8. doi: 10.1159/000339340. Epub 2012 Jun 26.
11. Elevated vitamin D receptor levels in genetic hypercalciuric stone-forming rats are associated with downregulation of Snail. Bai S, etal., J Bone Miner Res. 2010 Apr;25(4):830-40.
12. Distribution and subcellular immunolocalization of 1,25-dihydroxyvitamin D3 receptors in rat epiphyseal cartilage. Balmain N, etal., Cell Mol Biol (Noisy-le-grand). 1993 May;39(3):339-50.
13. Vitamin D receptor gene polymorphism is associated with Graves' disease in the Japanese population. Ban Y, etal., J Clin Endocrinol Metab. 2000 Dec;85(12):4639-43.
14. Enhancement of VDR-mediated transcription by phosphorylation: correlation with increased interaction between the VDR and DRIP205, a subunit of the VDR-interacting protein coactivator complex. Barletta F, etal., Mol Endocrinol 2002 Feb;16(2):301-14.
15. Genetic analysis of the vitamin D receptor gene in two epithelial cancers: melanoma and breast cancer case-control studies. Barroso E, etal., BMC Cancer. 2008 Dec 23;8:385. doi: 10.1186/1471-2407-8-385.
16. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
17. Regulation of renal vitamin D receptor is an important determinant of 1alpha,25-dihydroxyvitamin D(3) levels in vivo. Beckman MJ and DeLuca HF, Arch Biochem Biophys 2002 May 1;401(1):44-52.
18. Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis. Bozic M, etal., J Hepatol. 2016 Oct;65(4):748-757. doi: 10.1016/j.jhep.2016.05.031. Epub 2016 May 28.
19. Vitamin D receptor gene polymorphisms are associated with breast cancer risk in a UK Caucasian population. Bretherton-Watt D, etal., Br J Cancer. 2001 Jul 20;85(2):171-5.
20. Structure and regulation of the rat 1,25-dihydroxyvitamin D3 receptor. Burmester JK, etal., Proc Natl Acad Sci U S A 1988 Dec;85(24):9499-502.
21. Isolation and expression of rat 1,25-dihydroxyvitamin D3 receptor cDNA. Burmester JK, etal., Proc Natl Acad Sci U S A 1988 Feb;85(4):1005-9.
22. Vitamin D receptor gene as a candidate gene for Parkinson disease. Butler MW, etal., Ann Hum Genet. 2011 Mar;75(2):201-10. doi: 10.1111/j.1469-1809.2010.00631.x.
23. Vitamin D receptor gene polymorphisms in breast cancer. Buyru N, etal., Exp Mol Med. 2003 Dec 31;35(6):550-5.
24. The up-regulation of the parathyroid VDR expression by extracellular calcium is mediated by the ERK1/2-MAPK signaling pathway. Canadillas S, etal., Am J Physiol Renal Physiol. 2010 Feb 24.
25. Vitamin D receptor alleles b, a, and T: risk factors for sporadic primary hyperparathyroidism (HPT) but not HPT of uremia or MEN 1. Carling T, etal., Biochem Biophys Res Commun. 1997 Feb 13;231(2):329-32.
26. The genetic background of osteoporosis in cystic fibrosis: association analysis with polymorphic markers in four candidate genes. Castellani C, etal., J Cyst Fibros. 2006 Dec;5(4):229-35. Epub 2006 May 18.
27. Vitamin D receptor gene polymorphism(s) and breast cancer risk in north Indians. Chakraborty A, etal., Cancer Detect Prev. 2009;32(5-6):386-94.
28. Targeting expression of the human vitamin D receptor to the keratinocytes of vitamin D receptor null mice prevents alopecia. Chen CH, etal., Endocrinology. 2001 Dec;142(12):5386-9.
29. Association between vitamin-D receptor gene FokI polymorphism and Graves' disease among Taiwanese Chinese. Chen RH, etal., J Clin Lab Anal. 2007;21(3):173-7.
30. Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor. Chen X, etal., Mol Pharmacol. 2006 Jun;69(6):1913-23. Epub 2006 Feb 15.
31. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Chen XR, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Nov;37(6):847-51.
32. Association of polymorphisms in the vitamin D receptor promoter with idiopathic short stature. Choi SK, etal., J Korean Med Sci. 2013 Sep;28(9):1329-33. doi: 10.3346/jkms.2013.28.9.1329. Epub 2013 Aug 28.
33. Interaction between vitamin D receptor genotype and estrogen receptor alpha genotype influences vertebral fracture risk. Colin EM, etal., J Clin Endocrinol Metab. 2003 Aug;88(8):3777-84.
34. 1,25-Dihydroxyvitamin D3 regulates the expression of VDR and NGF gene in Schwann cells in vitro. Cornet A, etal., J Neurosci Res. 1998 Sep 15;53(6):742-6.
35. Association of polymorphisms in the vitamin D receptor gene and serum 25-hydroxyvitamin D levels in children with autism spectrum disorder. Coskun S, etal., Gene. 2016 Aug 22;588(2):109-14. doi: 10.1016/j.gene.2016.05.004. Epub 2016 May 4.
36. Vitamin D receptor stable transfection restores the susceptibility to 1,25-dihydroxyvitamin D3 cytotoxicity in a rat glioma resistant clone. Davoust N, etal., J Neurosci Res 1998 Apr 15;52(2):210-9.
37. Polymorphisms of vitamin D receptor gene in Turkish familial psoriasis patients. Dayangac-Erden D, etal., Arch Dermatol Res. 2007 Dec;299(10):487-91. Epub 2007 Sep 1.
38. 1,25-dihydroxyvitamin D3 and 22-oxacalcitriol prevent the decrease in vitamin D receptor content in the parathyroid glands of uremic rats. Denda M, etal., Kidney Int. 1996 Jul;50(1):34-9.
39. Prolactin blocks nuclear translocation of VDR by regulating its interaction with BRCA1 in osteosarcoma cells. Deng C, etal., Mol Endocrinol. 2009 Feb;23(2):226-36. doi: 10.1210/me.2008-0075. Epub 2008 Dec 12.
40. A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. Ding N, etal., Cell. 2013 Apr 25;153(3):601-13. doi: 10.1016/j.cell.2013.03.028.
41. Beta amyloid suppresses the expression of the vitamin d receptor gene and induces the expression of the vitamin d catabolic enzyme gene in hippocampal neurons. Dursun E, etal., Dement Geriatr Cogn Disord. 2013;36(1-2):76-86. doi: 10.1159/000350319. Epub 2013 Jun 7.
42. Vitamin D receptor signaling contributes to susceptibility to infection with Leishmania major. Ehrchen J, etal., FASEB J. 2007 Oct;21(12):3208-18. Epub 2007 Jun 5.
43. Genetic variation in the vitamin D receptor gene and vitamin D serum levels in Egyptian women with polycystic ovary syndrome. El-Shal AS, etal., Mol Biol Rep. 2013 Nov;40(11):6063-73.
44. Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis. Falleti E, etal., World J Gastroenterol. 2010 Jun 28;16(24):3016-24. doi: 10.3748/wjg.v16.i24.3016.
45. Genetic association of vitamin D receptor polymorphisms with autoimmune hepatitis and primary biliary cirrhosis in the Chinese. Fan L, etal., J Gastroenterol Hepatol. 2005 Feb;20(2):249-55. doi: 10.1111/j.1440-1746.2005.03532.x.
46. Association analysis of vitamin D receptor gene polymorphisms in chinese population with asthma. Fang WL, etal., Iran J Allergy Asthma Immunol. 2009 Sep;8(3):141-7.
47. Ontogenesis of the vitamin D receptor in rat heart. Fraga C, etal., Histochem Cell Biol. 2002 Jun;117(6):547-50. Epub 2002 May 16.
48. Mutant p53: one name, many proteins. Freed-Pastor WA and Prives C, Genes Dev. 2012 Jun 15;26(12):1268-86. doi: 10.1101/gad.190678.112.
49. The normal liver harbors the vitamin D nuclear receptor in nonparenchymal and biliary epithelial cells. Gascon-Barre M, etal., Hepatology. 2003 May;37(5):1034-42.
50. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
51. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
52. Vitamin D receptor levels and binding are reduced in aged rat intestinal subcellular fractions. Gonzalez Pardo V, etal., Biogerontology. 2008 Apr;9(2):109-18. Epub 2007 Dec 1.
53. Vitamin D receptor gene polymorphisms and breast cancer risk. Guy M, etal., Clin Cancer Res. 2004 Aug 15;10(16):5472-81.
54. Vitamin D receptor gene polymorphisms, particularly the novel A-1012G promoter polymorphism, are associated with vitamin D3 responsiveness and non-familial susceptibility in psoriasis. Halsall JA, etal., Pharmacogenet Genomics. 2005 May;15(5):349-55.
55. Polymorphisms in the MTHFR and VDR genes and skin cancer risk. Han J, etal., Carcinogenesis. 2007 Feb;28(2):390-7. Epub 2006 Aug 31.
56. Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state. Hansdottir S, etal., J Immunol. 2010 Jan 15;184(2):965-74. Epub 2009 Dec 11.
57. Association of vitamin D receptor gene polymorphisms with severe atopic dermatitis in adults. Heine G, etal., Br J Dermatol. 2013 Apr;168(4):855-8. doi: 10.1111/bjd.12077. Epub 2013 Mar 13.
58. Preventive effects of 1,25-(OH)2VD3 against ConA-induced mouse hepatitis through promoting vitamin D receptor gene expression. Hu XD, etal., Acta Pharmacol Sin. 2010 Jun;31(6):703-8. doi: 10.1038/aps.2010.53.
59. Vitamin D receptor gene polymorphisms and distinct clinical phenotypes of hepatitis B carriers in Taiwan. Huang YW, etal., Genes Immun. 2010 Jan;11(1):87-93. doi: 10.1038/gene.2009.65. Epub 2009 Aug 20.
60. Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets. Hughes MR, etal., Science. 1988 Dec 23;242(4886):1702-5.
61. The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1 alpha,25(OH)2-vitamin D3 in vivo and in vitro. Huhtakangas JA, etal., Mol Endocrinol. 2004 Nov;18(11):2660-71. Epub 2004 Jul 22.
62. Association of vitamin D receptor gene polymorphisms with response to peginterferon plus ribavirin in Asian patients with chronic hepatitis C. Hung CH, etal., J Formos Med Assoc. 2016 Apr;115(4):278-83. doi: 10.1016/j.jfma.2015.11.008. Epub 2015 Dec 22.
63. Vitamin D receptor polymorphisms are associated with altered prognosis in patients with malignant melanoma. Hutchinson PE, etal., Clin Cancer Res. 2000 Feb;6(2):498-504.
64. Intestinal vitamin D receptor modulates lipid metabolism, adipose tissue inflammation and liver steatosis in obese mice. Jahn D, etal., Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1567-1578. doi: 10.1016/j.bbadis.2019.03.007. Epub 2019 Mar 21.
65. Vitamin D Receptor Polymorphisms Are Associated with Reduced Esophageal Vitamin D Receptor Expression and Reduced Esophageal Adenocarcinoma Risk. Janmaat VT, etal., Mol Med. 2015 Apr 21;21:346-54. doi: 10.2119/molmed.2012.00336.
66. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. Janssen R, etal., J Infect Dis. 2007 Sep 15;196(6):826-34. Epub 2007 Aug 10.
67. Associations of vitamin D receptor gene polymorphisms FokI and BsmI with susceptibility to rheumatoid arthritis and Behcet's disease in Tunisians. Karray EF, etal., Joint Bone Spine. 2012 Mar;79(2):144-8. doi: 10.1016/j.jbspin.2011.06.003. Epub 2011 Aug 5.
68. Decreased Expression of Vitamin D Receptor Affects an Immune Response in Primary Biliary Cholangitis via the VDR-miRNA155-SOCS1 Pathway. Kempinska-Podhorodecka A, etal., Int J Mol Sci. 2017 Jan 29;18(2). pii: ijms18020289. doi: 10.3390/ijms18020289.
69. Vitamin D receptor gene polymorphisms and male breast cancer risk in Turkish population. Kizildag S, etal., J BUON. 2011 Oct-Dec;16(4):640-5.
70. Association of vitamin D receptor gene polymorphisms and bronchopulmonary dysplasia. Koroglu OA, etal., Pediatr Res. 2014 Aug;76(2):171-6. doi: 10.1038/pr.2014.63. Epub 2014 May 5.
71. Association of genetic variants of the vitamin D receptor (VDR) with cutaneous squamous cell carcinomas (SCC) and basal cell carcinomas (BCC): a pilot study in a German population. Kostner K, etal., Anticancer Res. 2012 Jan;32(1):327-33.
72. Mouse and human BAC transgenes recapitulate tissue-specific expression of the vitamin D receptor in mice and rescue the VDR-null phenotype. Lee SM, etal., Endocrinology. 2014 Jun;155(6):2064-76. doi: 10.1210/en.2014-1107. Epub 2014 Apr 2.
73. Genetic variants of the vitamin D receptor gene alter risk of cutaneous melanoma. Li C, etal., J Invest Dermatol. 2007 Feb;127(2):276-80. Epub 2006 Sep 21.
74. The association of vitamin D receptor gene polymorphisms and serum 25-hydroxyvitamin D levels with generalized vitiligo. Li K, etal., Br J Dermatol. 2012 Oct;167(4):815-21. doi: 10.1111/j.1365-2133.2012.11132.x.
75. Polymorphism rs2239185 in vitamin D receptor gene is associated with severe community-acquired pneumonia of children in Chinese Han population: a case-control study. Li W, etal., Eur J Pediatr. 2015 May;174(5):621-9. doi: 10.1007/s00431-014-2433-0. Epub 2014 Nov 1.
76. Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Li YC, etal., Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9831-5.
77. Immunoaffinity purification of active rat recombinant 1,25-dihydroxyvitamin D3 receptor. Li Z, etal., Arch Biochem Biophys. 1994 May 1;310(2):347-51.
78. Vitamin D receptor mutations in patients with hereditary 1,25-dihydroxyvitamin D-resistant rickets. Malloy PJ, etal., Mol Genet Metab. 2014 Jan;111(1):33-40. doi: 10.1016/j.ymgme.2013.10.014. Epub 2013 Nov 4.
79. DNA methylation-related vitamin D receptor insensitivity in breast cancer. Marik R, etal., Cancer Biol Ther. 2010 Jul 1;10(1):44-53. Epub 2010 Jul 9.
80. 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis. Mayne CG, etal., Eur J Immunol. 2011 Mar;41(3):822-32. doi: 10.1002/eji.201040632. Epub 2011 Feb 1.
81. Hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia in four Egyptian families: report of three novel mutations in the vitamin D receptor gene. Mazen I, etal., J Pediatr Endocrinol Metab. 2014 Sep;27(9-10):873-8. doi: 10.1515/jpem-2013-0443.
82. Expression of 25-hydroxyvitamin D-1-alpha-hydroxylase, and vitamin D receptor mRNA in normal and malignant breast tissue. McCarthy K, etal., Anticancer Res. 2009 Jan;29(1):155-7.
83. Vitamin D receptor polymorphisms and breast cancer risk: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. McKay JD, etal., Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):297-305. doi: 10.1158/1055-9965.EPI-08-0539.
84. The NRAMPI, VDR and TNF-alpha gene polymorphisms in Iranian tuberculosis patients: the study on host susceptibility. Merza M, etal., Braz J Infect Dis. 2009 Aug;13(4):252-6.
85. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
86. Unifying candidate gene and GWAS Approaches in Asthma. Michel S, etal., PLoS One. 2010 Nov 12;5(11):e13894.
87. Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women. Mishra DK, etal., PLoS One. 2013;8(3):e57967. doi: 10.1371/journal.pone.0057967. Epub 2013 Mar 12.
88. Analysis of the vitamin D system in basal cell carcinomas (BCCs). Mitschele T, etal., Lab Invest. 2004 Jun;84(6):693-702.
89. The vitamin D receptor agonist elocalcitol upregulates L-type calcium channel activity in human and rat bladder. Morelli A, etal., Am J Physiol Cell Physiol. 2008 May;294(5):C1206-14. Epub 2008 Mar 19.
90. Influence of vitamin D receptor gene polymorphisms and 25-hydroxyvitamin D on blood pressure in apparently healthy subjects. Muray S, etal., J Hypertens. 2003 Nov;21(11):2069-75.
91. A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia. Na S, etal., Autoimmune Dis. 2011 Jan 26;2011:132958. doi: 10.4061/2011/132958.
92. Association of vitamin D receptors with the nuclear matrix of human and rat genitourinary tissues. Nangia AK, etal., J Steroid Biochem Mol Biol. 1998 Aug;66(4):241-6.
93. Positive association of vitamin D receptor gene variations with multiple sclerosis in South East Iranian population. Narooie-Nejad M, etal., Biomed Res Int. 2015;2015:427519. doi: 10.1155/2015/427519. Epub 2015 Jan 20.
94. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
95. Placental vitamin D receptor expression is decreased in human idiopathic fetal growth restriction. Nguyen TP, etal., J Mol Med (Berl). 2015 Jul;93(7):795-805. doi: 10.1007/s00109-015-1267-1. Epub 2015 Feb 27.
96. Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions. Nishikawa M, etal., Sci Rep. 2020 Mar 30;10(1):5677. doi: 10.1038/s41598-020-62048-1.
97. Deletion of macrophage Vitamin D receptor promotes insulin resistance and monocyte cholesterol transport to accelerate atherosclerosis in mice. Oh J, etal., Cell Rep. 2015 Mar 24;10(11):1872-86. doi: 10.1016/j.celrep.2015.02.043.
98. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
99. Vitamin D receptor gene polymorphism BsmI is not associated with the prevalence and severity of CAD in a large-scale angiographic cohort of 3441 patients. Ortlepp JR, etal., Eur J Clin Invest. 2003 Feb;33(2):106-9.
100. The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis. Ortlepp JR, etal., Heart. 2001 Jun;85(6):635-8.
101. Interaction of the 1alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling. Paredes R, etal., Biochem J 2002 May 1;363(Pt 3):667-76.
102. Association of single nucleotide polymorphisms in VDR and DBP genes with HBV-related hepatocellular carcinoma risk in a Chinese population. Peng Q, etal., PLoS One. 2014 Dec 26;9(12):e116026. doi: 10.1371/journal.pone.0116026. eCollection 2014.
103. Vitamin D receptor genotypes are associated with bone mass in patients with Turner syndrome. Peralta López M, etal., J Pediatr Endocrinol Metab. 2011;24(5-6):307-12.
104. Vitamin D receptor genotype rs731236 (Taq1) and breast cancer prognosis. Perna L, etal., Cancer Epidemiol Biomarkers Prev. 2013 Mar;22(3):437-42. doi: 10.1158/1055-9965.EPI-12-0970-T. Epub 2013 Jan 8.
105. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
106. Polymorphisms of vitamin D receptor gene in the population of eastern Croatia with psoriasis vulgaris and diabetes mellitus. Polic MV, etal., Coll Antropol. 2012 Jun;36(2):451-7.
107. 1.25-Dihydroxyvitamin D3 receptor is partly colocalized with oxytocin immunoreactivity in neurons of the male rat hypothalamus. Prufer K and Jirikowski GF, Cell Mol Biol (Noisy-le-grand). 1997 Jun;43(4):543-8.
108. Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Raby BA, etal., Am J Respir Crit Care Med. 2004 Nov 15;170(10):1057-65. Epub 2004 Jul 28.
109. Vitamin D receptor polymorphisms are associated with Graves' disease in German and Polish but not in Serbian patients. Ramos-Lopez E, etal., Thyroid. 2005 Oct;15(10):1125-30.
110. Vitamin D receptor gene polymorphisms, serum 25-hydroxyvitamin D levels, and melanoma: UK case-control comparisons and a meta-analysis of published VDR data. Randerson-Moor JA, etal., Eur J Cancer. 2009 Dec;45(18):3271-81. doi: 10.1016/j.ejca.2009.06.011. Epub 2009 Jul 15.
111. GOA pipeline RGD automated data pipeline
112. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
113. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
114. A-1012G Promoter Polymorphism of Vitamin D Receptor Gene Is Associated with Psoriasis Risk and Lower Allele-Specific Expression. Richetta AG, etal., DNA Cell Biol. 2013 Dec 9.
115. Association between vitamin D receptor gene polymorphisms and response to treatment of pulmonary tuberculosis. Roth DE, etal., J Infect Dis. 2004 Sep 1;190(5):920-7. Epub 2004 Jul 29.
116. Vitamin D receptor polymorphisms and the risk of acute lower respiratory tract infection in early childhood. Roth DE, etal., J Infect Dis. 2008 Mar 1;197(5):676-80.
117. Lack of association of vitamin D receptor gene 3'-haplotypes with psoriasis in Croatian patients. Rucevic I, etal., J Dermatol. 2012 Jan;39(1):58-62. doi: 10.1111/j.1346-8138.2011.01296.x. Epub 2011 Sep 27.
118. Vitamin D receptor gene polymorphism is associated with metastatic breast cancer. Ruggiero M, etal., Oncol Res. 1998;10(1):43-6.
119. Clinical and genetic predictors of response to narrowband ultraviolet B for the treatment of chronic plaque psoriasis. Ryan C, etal., Br J Dermatol. 2010 Nov;163(5):1056-63. doi: 10.1111/j.1365-2133.2010.09985.x.
120. Association study between vitamin D receptor gene polymorphisms and asthma in the Chinese Han population: a case-control study. Saadi A, etal., BMC Med Genet. 2009 Jul 21;10:71.
121. No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case-control study. Schafer A, etal., Arch Dermatol Res. 2012 Jul;304(5):353-61. doi: 10.1007/s00403-012-1243-3. Epub 2012 May 11.
122. Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study. Schmidt RJ, etal., Early Hum Dev. 2015 Aug;91(8):483-9. doi: 10.1016/j.earlhumdev.2015.05.008. Epub 2015 Jun 11.
123. Estrogen controls expression and bioresponse of 1,25-dihydroxyvitamin D receptors in the rat colon. Schwartz B, etal., Mol Cell Biochem. 2000 Jan;203(1-2):87-93.
124. Regulatory region polymorphisms of vitamin D receptor gene in pulmonary tuberculosis patients and normal healthy subjects of south India. Selvaraj P, etal., Int J Immunogenet. 2008 Jun;35(3):251-4. Epub 2008 Apr 7.
125. Regulatory role of promoter and 3' UTR variants of vitamin D receptor gene on cytokine response in pulmonary tuberculosis. Selvaraj P, etal., J Clin Immunol. 2008 Jul;28(4):306-13. Epub 2008 Jan 30.
126. [Relationship between polymorphisms of vitamin D receptor gene and familial aggregation of HBsAg carriers]. Shan J, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Apr;28(2):148-53.
127. Association of vitamin D receptor gene polymorphism with susceptibility to Graves' disease in Eastern Croatian population: case-control study. Stefanic M, etal., Croat Med J. 2005 Aug;46(4):639-46.
128. Vitamin D receptor gene polymorphism is associated with chronic periodontitis. Tachi Y, etal., Life Sci. 2003 Nov 14;73(26):3313-21.
129. Vitamin D receptor polymorphisms are associated with increased susceptibility to primary biliary cirrhosis in Japanese and Italian populations. Tanaka A, etal., J Hepatol. 2009 Jun;50(6):1202-9. doi: 10.1016/j.jhep.2009.01.015. Epub 2009 Mar 5.
130. Association between a protein polymorphism in the start codon of the vitamin D receptor gene and severe diabetic retinopathy in C-peptide-negative type 1 diabetes. Taverna MJ, etal., J Clin Endocrinol Metab. 2005 Aug;90(8):4803-8. Epub 2005 May 17.
131. Genetic polymorphisms of vitamin D receptor (VDR) in Fabry disease. Teitcher M, etal., Genetica. 2008 Nov;134(3):377-83. doi: 10.1007/s10709-008-9245-y. Epub 2008 Feb 16.
132. Vitamin D receptor TaqI and ApaI polymorphisms: a comparative study in patients with Behçet's disease and Rheumatoid arthritis in Tunisian population. Tizaoui K, etal., Cell Immunol. 2014 Jul;290(1):66-71. doi: 10.1016/j.cellimm.2014.05.002. Epub 2014 May 17.
133. Investigation of vitamin D receptor polymorphisms in amyotrophic lateral sclerosis. Torok N, etal., Acta Neurol Scand. 2016 Apr;133(4):302-8. doi: 10.1111/ane.12463. Epub 2015 Jul 20.
134. Prognostic significance of vitamin D receptor (VDR) gene polymorphisms in liver cirrhosis. Triantos C, etal., Sci Rep. 2018 Sep 14;8(1):14065. doi: 10.1038/s41598-018-32482-3.
135. A human vitamin D receptor mutation causes rickets and impaired Th1/Th17 responses. van der Eerden BC, etal., Bone. 2014 Dec;69:6-11. doi: 10.1016/j.bone.2014.08.005. Epub 2014 Sep 6.
136. Putative susceptibility markers of coronary artery disease: association between VDR genotype, smoking, and aromatic DNA adduct levels in human right atrial tissue. Van Schooten FJ, etal., FASEB J. 1998 Oct;12(13):1409-17.
137. [Association of Vitamin D Receptor Polymorphisms with Response to Antiviral Therapy in Patients with Chronic Hepatitis C]. Wang C, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2016 Mar;47(2):227-31.
138. Relationship between vitamin D receptor (VDR) polymorphisms and the efficacy of recombinant human growth hormone (rhGH) treatment in children with idiopathic short stature. Wang W, etal., Genet Mol Res. 2015 Sep 8;14(3):10507-14. doi: 10.4238/2015.September.8.12.
139. Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammation. Wittke A, etal., Arch Biochem Biophys. 2007 Apr 15;460(2):306-13. Epub 2007 Jan 2.
140. Vitamin D receptor biochemical and genetic profiling and HLA-class II genotyping among Lebanese with multiple sclerosis - A pilot study. Yamout B, etal., J Neuroimmunol. 2016 Apr 15;293:59-64. doi: 10.1016/j.jneuroim.2016.02.008. Epub 2016 Feb 15.
141. Vitamin D receptor activation protects against myocardial reperfusion injury through inhibition of apoptosis and modulation of autophagy. Yao T, etal., Antioxid Redox Signal. 2015 Mar 10;22(8):633-50. doi: 10.1089/ars.2014.5887. Epub 2015 Jan 14.
142. Otosclerosis and vitamin D receptor gene polymorphism. Yildirim YS, etal., Am J Otolaryngol. 2013 Sep-Oct;34(5):454-7. doi: 10.1016/j.amjoto.2013.03.016. Epub 2013 Apr 29.
143. Association of bone metabolism related genes polymorphisms with the effect of raloxifene hydrochloride on bone mineral density and bone turnover markers in postmenopausal women with osteoporosis. Zhang ZL, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Apr;23(2):129-33.
144. Membrane localization, Caveolin-3 association and rapid actions of vitamin D receptor in cardiac myocytes. Zhao G and Simpson RU, Steroids. 2010 Aug-Sep;75(8-9):555-9. Epub 2009 Dec 14.
145. The association of polymorphisms of the vitamin D receptor gene with psoriasis in the Han population of northeastern China. Zhou X, etal., J Dermatol Sci. 2014 Jan;73(1):63-6. doi: 10.1016/j.jdermsci.2013.08.014. Epub 2013 Sep 7.
146. Effect of estrogen and progesterone on the expression of 1, 25-dihydroxyvitamin D receptors mRNA in the liver of ovariectomized rats. Zhou Y, etal., Di Yi Jun Yi Da Xue Xue Bao 2002 Jun;22(6):521-3.
147. Vitamin D receptor is highly expressed in precancerous lesions and esophageal adenocarcinoma with significant sex difference. Zhou Z, etal., Hum Pathol. 2014 Aug;45(8):1744-51. doi: 10.1016/j.humpath.2014.02.029. Epub 2014 May 15.
148. Vitamin D receptor status alters mammary gland morphology and tumorigenesis in MMTV-neu mice. Zinser GM and Welsh J, Carcinogenesis. 2004 Dec;25(12):2361-72. Epub 2004 Aug 27.
Additional References at PubMed
PMID:9241280   PMID:9295274   PMID:10678179   PMID:10866662   PMID:11687634   PMID:11891224   PMID:12016314   PMID:12198242   PMID:12444213   PMID:12771291   PMID:15178742   PMID:15322135  
PMID:15456860   PMID:15589699   PMID:15589866   PMID:15601867   PMID:15601870   PMID:16130132   PMID:16521124   PMID:16549446   PMID:16720713   PMID:16835013   PMID:16927375   PMID:17054913  
PMID:17082781   PMID:17118558   PMID:17223341   PMID:17254542   PMID:17426122   PMID:17535892   PMID:17658451   PMID:17786964   PMID:17974622   PMID:18410228   PMID:18502116   PMID:18534255  
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PMID:35662320   PMID:36497006  


Genomics

Comparative Map Data
Vdr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27128,987,981 - 129,037,677 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7128,987,981 - 129,037,677 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7130,785,124 - 130,834,890 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07133,010,661 - 133,060,429 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07132,923,119 - 132,972,888 (-)NCBIRnor_WKY
Rnor_6.07139,344,452 - 139,394,138 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,342,063 - 139,394,166 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,536,241 - 139,585,928 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47136,567,614 - 136,617,280 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17136,644,050 - 136,693,717 (-)NCBI
Celera7125,479,125 - 125,528,679 (-)NCBICelera
Cytogenetic Map7q36NCBI
VDR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381247,841,537 - 47,904,994 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1247,841,537 - 47,943,048 (-)EnsemblGRCh38hg38GRCh38
GRCh371248,235,320 - 48,298,777 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361246,521,587 - 46,585,081 (-)NCBINCBI36Build 36hg18NCBI36
Build 341246,521,588 - 46,585,036NCBI
Celera1247,032,871 - 47,096,518 (-)NCBICelera
Cytogenetic Map12q13.11NCBI
HuRef1245,266,368 - 45,330,677 (-)NCBIHuRef
CHM1_11248,201,212 - 48,264,704 (-)NCBICHM1_1
T2T-CHM13v2.01247,802,918 - 47,866,398 (-)NCBIT2T-CHM13v2.0
Vdr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391597,752,308 - 97,806,177 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1597,752,306 - 97,808,511 (-)EnsemblGRCm39 Ensembl
GRCm381597,854,427 - 97,908,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1597,854,425 - 97,910,630 (-)EnsemblGRCm38mm10GRCm38
MGSCv371597,684,858 - 97,738,727 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361597,682,461 - 97,736,330 (-)NCBIMGSCv36mm8
Celera1599,981,938 - 100,035,599 (-)NCBICelera
Cytogenetic Map15F1NCBI
Vdr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555006,745,678 - 6,798,048 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555006,745,725 - 6,798,052 (-)NCBIChiLan1.0ChiLan1.0
VDR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11241,661,688 - 41,766,192 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1241,702,742 - 41,766,192 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01240,828,413 - 40,891,700 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
VDR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,852,915 - 6,909,466 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,852,723 - 6,909,470 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2739,397,549 - 39,454,181 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0276,920,266 - 6,976,964 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,921,548 - 6,976,937 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,857,514 - 6,914,062 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0276,892,693 - 6,949,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02739,686,018 - 39,742,660 (-)NCBIUU_Cfam_GSD_1.0
Vdr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494567,363,831 - 67,424,087 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365125,740,748 - 5,801,109 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365125,741,836 - 5,800,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VDR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl578,205,810 - 78,266,475 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1578,205,807 - 78,266,505 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2581,279,217 - 81,338,475 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VDR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11144,062,198 - 44,126,295 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1144,065,457 - 44,166,684 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037202,254,076 - 202,319,396 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vdr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248164,365,961 - 4,424,514 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248164,314,146 - 4,423,946 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vdr
164 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:85
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000011601
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat


Genetic Models
This gene Vdr is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 27 2
Low 28 21 5 19 5 5 6 5 4 34 9 5
Below cutoff 15 36 36 36 3 5 39 4 7 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000082429   ⟹   ENSRNOP00000070446
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7128,987,981 - 129,037,677 (-)Ensembl
Rnor_6.0 Ensembl7139,342,063 - 139,394,166 (-)Ensembl
RefSeq Acc Id: NM_017058   ⟹   NP_058754
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27128,987,981 - 129,037,677 (-)NCBI
Rnor_6.07139,344,452 - 139,394,138 (-)NCBI
Rnor_5.07139,536,241 - 139,585,928 (-)NCBI
RGSC_v3.47136,567,614 - 136,617,280 (-)RGD
Celera7125,479,125 - 125,528,679 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058754 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41089 (Get FASTA)   NCBI Sequence Viewer  
  EDL87095 (Get FASTA)   NCBI Sequence Viewer  
  P13053 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058754   ⟸   NM_017058
- UniProtKB: G3V744 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070446   ⟸   ENSRNOT00000082429
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13053-F1-model_v2 AlphaFold P13053 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695618
Promoter ID:EPDNEW_R6143
Type:initiation region
Name:Vdr_1
Description:vitamin D receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07139,394,157 - 139,394,217EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3959 AgrOrtholog
BioCyc Gene G2FUF-32166 BioCyc
Ensembl Genes ENSRNOG00000054420 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070446 ENTREZGENE
  ENSRNOP00000070446.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082429 ENTREZGENE
  ENSRNOT00000082429.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DBD_VDR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VitD_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24873 UniProtKB/Swiss-Prot
NCBI Gene 24873 ENTREZGENE
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB VDR RGD
PhenoGen Vdr PhenoGen
PRINTS STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VITAMINDR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V744 ENTREZGENE, UniProtKB/TrEMBL
  P13053 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-12 Vdr  vitamin D receptor  Vdr  vitamin D (1,25- dihydroxyvitamin D3) receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Vdr  vitamin D (1,25- dihydroxyvitamin D3) receptor  Vdr  vitamin D receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Vdr  vitamin D receptor      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Vdr  vitamin D receptor      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in osteoblasts 70308
gene_function binds vitamin D 70308
gene_function binds vitamin D 70543
gene_process mediates action of vitamin D as a transcription factor 70308
gene_process mediates action of vitamin D as a transcription factor 70543
gene_process functions in apoptosis in glioma cells 70308
gene_process functions in apoptosis in glioma cells 70543
gene_process expression is required, but not sufficient, for vitamin D mediated apoptosis in glioma cells 70308
gene_transcript has 10 exons