Nos3 (nitric oxide synthase 3) - Rat Genome Database
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Gene: Nos3 (nitric oxide synthase 3) Rattus norvegicus
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Symbol: Nos3
Name: nitric oxide synthase 3
RGD ID: 3186
Description: Exhibits several functions, including Hsp90 protein binding activity; beta-catenin binding activity; and calmodulin binding activity. Involved in several processes, including cellular response to magnesium ion; cellular response to mechanical stimulus; and cellular response to organonitrogen compound. Localizes to several cellular components, including caveola; nucleolus; and sarcolemma. Used to study artery disease (multiple); irritable bowel syndrome; ischemia (multiple); liver disease (multiple); and retinal disease (multiple). Biomarker of several diseases, including artery disease (multiple); kidney failure (multiple); liver disease (multiple); lung disease (multiple); and overnutrition (multiple). Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); eye disease (multiple); reproductive organ cancer (multiple); and vasculitis (multiple). Orthologous to human NOS3 (nitric oxide synthase 3); PARTICIPATES IN doxorubicin pharmacokinetics pathway; eicosanoid signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH (R)-carnitine; 1,3-dinitrobenzene; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cNOS; constitutive NOS; EC-NOS; endothelial nitric oxide synthase 3; endothelial NOS; eNos; nitric oxide synthase 3, endothelial cell; nitric oxide synthase, endothelial; NOS type III; NOSIII
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Nos3em2Mcwi   Nos3em8Mcwi   Nos3em13Mcwi  
Genetic Models: SS-Nos3em8Mcwi SS-Nos3em2Mcwi SS-Nos3em13Mcwi
Is Marker For: Strains:   WKY   DA.WF-(D4Mit11-Nos3)/Kop  
QTLs:   Tcas3   BW384_H  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.047,321,908 - 7,342,404 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,320,668 - 7,342,410 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,333,272 - 7,353,767 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,158,847 - 6,179,441 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.146,158,846 - 6,179,441 (-)NCBI
Celera46,408,408 - 6,428,650 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute chest syndrome  (ISO)
acute kidney failure  (IEP,ISO)
Acute Liver Failure  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 1  (ISO)
angle-closure glaucoma  (ISO)
anterior ischemic optic neuropathy  (ISO)
aortic valve disease  (ISS)
arteriosclerosis  (ISO)
Arteriovenous Fistula  (IEP)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Behcet's disease  (ISO)
bladder neck obstruction  (IEP)
Brain Hypoxia  (IEP)
brain ischemia  (IDA,IMP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (IEP)
Cardiomegaly  (IEP,ISO)
cardiomyopathy  (IEP,ISO)
Cardiotoxicity  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (IEP)
central sleep apnea  (ISO)
cerebral infarction  (ISO)
Child Behavior Disorders  (ISO)
cholestasis  (IEP)
Chronic Cerebral Hypoperfusion  (IMP)
chronic kidney disease  (IEP)
chronic obstructive pulmonary disease  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
colitis  (IEP)
congenital diaphragmatic hernia  (IEP)
congestive heart failure  (IEP,ISO)
coronary artery disease  (ISO)
coronary artery vasospasm  (ISO)
cystic fibrosis  (ISO)
diabetic angiopathy  (IEP,ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Gastroparesis  (IEP)
Diabetic Nephropathies  (IEP,ISO)
diabetic retinopathy  (IDA,IEP,ISO)
Diaphragmatic Hernia  (IEP,ISO)
disease of cellular proliferation  (ISO)
Drug-Induced Enteropathy  (IDA)
end stage renal disease  (IEP,ISO)
endometrial carcinoma  (ISO)
Endotoxemia  (IEP)
Esophageal Neoplasms  (ISO)
essential hypertension  (ISO)
Experimental Arthritis  (IEP)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
extrahepatic cholestasis  (ISO)
familial hyperlipidemia  (IEP,ISO)
Fetal Growth Retardation  (IEP,ISO)
gastric ulcer  (IEP,ISO)
Graft Occlusion, Vascular  (ISO)
Hemorrhagic Shock  (IEP)
Hepatic Insufficiency  (ISO)
Hepatomegaly  (ISO)
hepatopulmonary syndrome  (IEP)
Huntington's disease  (IEP)
Hyperemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxia  (IEP)
hypertension  (IDA,IEP,ISO)
Hypertension Resistant to Conventional Therapy  (ISO)
Hypertriglyceridemia  (IEP)
hypothyroidism  (IEP)
Hypoxia  (ISO)
impotence  (IEP,ISO)
Insulin Resistance  (IEP,ISO)
intestinal perforation  (ISO)
Intestinal Reperfusion Injury  (IDA)
Intimal Hyperplasia  (ISO)
intracranial aneurysm  (IEP,ISO)
Intracranial Hemorrhages  (IMP)
irritable bowel syndrome  (IDA)
ischemia  (ISO)
Kidney Reperfusion Injury  (IEP)
Kuhnt-Junius degeneration  (ISO)
Left Ventricular Hypertrophy  (IEP)
leiomyoma  (ISO)
Limb Ischemia  (IDA,IEP,ISO)
liver cirrhosis  (IDA,IEP)
Liver Reperfusion Injury  (IEP)
long QT syndrome  (ISO)
lung disease  (IEP,ISO)
Lung Reperfusion Injury  (IMP,ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
macular retinal edema  (ISO)
male infertility  (ISO)
malignant glioma  (ISO)
Metabolic Syndrome  (IDA,IMP,ISO)
migraine  (ISO)
myocardial infarction  (IDA,IEP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IDA,IEP,IMP,ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
obesity  (IEP)
obstructive sleep apnea  (ISO)
oligospermia  (ISO)
ovarian cancer  (ISO)
overnutrition  (IEP)
Pain  (IMP)
Perennial Allergic Rhinitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
persistent fetal circulation syndrome  (ISS)
Phyllodes Tumor  (ISO)
placental abruption  (ISO)
polycystic kidney disease  (IEP)
portal hypertension  (IDA,IEP,ISO)
pre-eclampsia  (IEP,ISO)
Preeclampsia/Eclampsia 1  (ISO)
Pregnancy-Induced Hypertension  (ISO)
premature ovarian failure  (ISO)
primary biliary cholangitis  (ISO)
primary open angle glaucoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary edema  (IEP,ISO)
pulmonary embolism  (IEP)
pulmonary emphysema  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary hypertension  (IDA,IEP,IMP,ISO)
Pulmonary Hypertension, Hypoxia-Induced  (IEP)
Radiation Pneumonitis  (ISO)
renal hypertension  (IDA)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Retina Reperfusion Injury  (IDA,IEP)
retinal degeneration  (IDA,IEP)
retinopathy of prematurity  (ISO)
Right Ventricular Hypertrophy  (IDA)
Sepsis  (ISO)
sickle cell anemia  (ISO)
Spinal Cord Compression  (IEP)
Spinal Cord Injuries  (IEP)
Stomach Neoplasms  (ISO)
Stroke  (IEP,ISO)
Subarachnoid Hemorrhage  (IEP)
Sudden Hearing Loss  (ISO)
telangiectasis  (ISO)
Teratozoospermia  (ISO)
Testis Reperfusion Injury  (IEP)
Thromboembolism  (ISO)
Thrombotic Microangiopathies  (IEP)
transient cerebral ischemia  (IDA,IEP)
Transplant Rejection  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
vasculitis  (ISO)
Vaso-occlusive Crisis  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Right  (IMP)
Ventricular Premature Complexes  (ISO)
Ventricular Tachycardia  (ISO)
vestibular disease  (ISO)
vulva cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
11-deoxycorticosterone  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic GMP  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3-diphenyl-N-(1-phenylethyl)-1-propanamine  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5,6,7,8-tetrahydrobiopterin  (ISO)
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetylcholine  (EXP,ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
AICA ribonucleotide  (EXP)
alcohol  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldrin  (ISO)
alkaloid  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
allopurinol  (EXP)
alpha-hexachlorocyclohexane  (ISO)
alpha-Zearalanol  (ISO)
aminoguanidine  (ISO)
amiodarone  (ISO)
amlodipine  (EXP)
ammonium chloride  (EXP)
anagliptin  (ISO)
ANTU  (EXP)
apocynin  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrasentan  (EXP)
atrazine  (ISO)
axitinib  (ISO)
BAPTA  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
benzoic acid  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
Calcimycin  (EXP,ISO)
calciol  (EXP)
calcitriol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calmidazolium  (EXP)
camostat  (EXP)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP)
capsaicin  (EXP,ISO)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
carvedilol  (EXP)
cetirizine  (ISO)
chelerythrine  (EXP)
chlorogenic acid  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
chrysin  (EXP)
cilostazol  (ISO)
cinnamic acid  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP)
cloricromen  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (ISO)
curcumin  (ISO)
cyanidin cation  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
DDE  (ISO)
Decursin  (ISO)
Deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dichlorine  (EXP)
digitoxin  (ISO)
digoxin  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP,ISO)
elemental selenium  (ISO)
enalapril  (EXP,ISO)
endosulfan  (EXP,ISO)
enzyme inhibitor  (EXP)
eplerenone  (EXP)
equol  (ISO)
erucic acid  (EXP)
esculetin  (EXP)
estriol  (ISO)
ethanol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
everolimus  (ISO)
fenofibrate  (ISO)
Fexofenadine hydrochloride  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
fluorene  (ISO)
flutamide  (EXP)
fluvastatin  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
formic acid  (EXP)
formononetin  (EXP)
fosinopril  (EXP)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
furosemide  (EXP)
genistein  (ISO)
gentamycin  (EXP,ISO)
ginsenoside Re  (ISO)
Ginsenoside Rg5  (EXP)
gliclazide  (EXP)
glucose  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
GW 501516  (ISO)
hemin  (EXP)
hexachlorobenzene  (EXP,ISO)
hexacosan-1-ol  (EXP)
hexadecanoic acid  (EXP,ISO)
high-density lipoprotein cholesterol  (ISO)
histamine  (EXP)
homocysteine  (ISO)
hydrochlorothiazide  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
icariin  (EXP,ISO)
indometacin  (EXP,ISO)
iron dextran  (EXP)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
isosorbide dinitrate  (ISO)
L-ascorbic acid  (EXP,ISO)
L-erythro-7,8-dihydrobiopterin  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
lead(II) chloride  (ISO)
levamisole  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
luteolin  (EXP)
LY294002  (EXP,ISO)
lysophosphatidylcholine  (EXP)
Magnolol  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
manidipine  (EXP)
masoprocol  (ISO)
medroxyprogesterone acetate  (EXP,ISO)
melatonin  (ISO)
menadione  (EXP)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methacholine chloride  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
metoprolol  (EXP)
mifepristone  (ISO)
miquelianin  (ISO)
monocrotaline  (EXP)
myricitrin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naphthalene  (ISO)
nebivolol  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP,ISO)
nifedipine  (ISO)
nitrates  (EXP)
nitric oxide  (EXP,ISO)
nitrites  (EXP,ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
nitroglycerin  (EXP)
nitroprusside  (ISO)
notoginsenoside R1  (ISO)
oleic acid  (ISO)
olmesartan  (EXP)
orotic acid  (ISO)
orphenadrine  (EXP)
Osajin  (ISO)
ouabain  (EXP)
ozone  (EXP)
paclitaxel  (ISO)
palytoxin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
paricalcitol  (ISO)
PD123319  (ISO)
pentaerythritol tetranitrate  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
peroxynitrous acid  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phloretin  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP)
Pomiferin  (ISO)
potassium chloride  (EXP,ISO)
pravastatin  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
propazine  (ISO)
propranolol  (EXP)
protoporphyrin  (ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (EXP)
rac-lactic acid  (ISO)
raloxifene  (EXP)
ramipril  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
Rosavin  (ISO)
rosmarinic acid  (EXP)
rosuvastatin calcium  (EXP,ISO)
rotenone  (ISO)
roxarsone  (ISO)
salicylic acid  (EXP)
salsalate  (EXP)
sapropterin  (ISO)
sarpogrelate  (EXP)
SB 203580  (ISO)
scutellarin  (EXP)
selenium atom  (ISO)
sepiapterin  (ISO)
sibutramine  (ISO)
sildenafil citrate  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simazine  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium azide  (ISO)
sodium chloride  (EXP)
sodium nitrate  (ISO)
Sodium salicylate  (ISO)
Soman  (EXP)
stilbenoid  (ISO)
streptozocin  (EXP)
sucrose  (EXP)
sulfur dioxide  (ISO)
superoxide  (EXP,ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (ISO)
tangeretin  (EXP)
Tanshinone I  (EXP,ISO)
telmisartan  (ISO)
tenofovir disoproxil fumarate  (ISO)
terbutylazine  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (ISO)
theaflavin  (ISO)
thioacetamide  (EXP)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (ISO)
torcetrapib  (EXP,ISO)
trans-caffeic acid  (ISO)
trans-cinnamic acid  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
ubiquinones  (ISO)
udenafil  (EXP)
uranium atom  (EXP)
urethane  (ISO)
ursolic acid  (ISO)
valsartan  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vanillic acid  (ISO)
vitamin E  (EXP,ISO)
wortmannin  (EXP,ISO)
Y-27632  (ISO)
zidovudine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zolmitriptan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
angiogenesis  (IEA,ISO)
aortic valve morphogenesis  (IEA,ISO)
arginine catabolic process  (IBA,IEA,ISO)
blood vessel diameter maintenance  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
bone development  (IEP)
cellular response to cAMP  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to heat  (IEP)
cellular response to high density lipoprotein particle stimulus  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to low-density lipoprotein particle stimulus  (IEP)
cellular response to magnesium ion  (IEP)
cellular response to mechanical stimulus  (IMP)
cellular response to organic cyclic compound  (IEP)
cellular response to rotenone  (IEP)
cellular response to transforming growth factor beta stimulus  (IMP)
cellular response to tumor necrosis factor  (IEP)
endocardial cushion morphogenesis  (IEA,ISO)
endothelial cell migration  (IEA,ISO)
female pregnancy  (IEP)
homeostasis of number of cells within a tissue  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
lung development  (IEA,ISO)
negative regulation of biomineral tissue development  (IEA,ISO)
negative regulation of blood pressure  (IBA)
negative regulation of calcium ion transport  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of hydrolase activity  (IEA,ISO)
negative regulation of muscle hyperplasia  (IEA,ISO)
negative regulation of potassium ion transport  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (IEA,IMP,ISO)
nitric oxide biosynthetic process  (IBA,IEA,IEP,IMP,ISO)
nitric oxide mediated signal transduction  (IBA)
obsolete oxidation-reduction process  (IEA)
ovulation from ovarian follicle  (IEA,ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of guanylate cyclase activity  (IBA,IEA,ISO)
pulmonary valve morphogenesis  (IEA,ISO)
regulation of nervous system process  (IEA,ISO)
regulation of sodium ion transport  (IEA,ISO)
regulation of systemic arterial blood pressure by endothelin  (IEA,ISO)
regulation of the force of heart contraction by chemical signal  (IEA,ISO)
removal of superoxide radicals  (IEA,ISO)
response to activity  (IEP)
response to amino acid  (IEP)
response to axon injury  (IEP)
response to candesartan  (IEP)
response to carbohydrate  (IEP)
response to corticosterone  (IEP)
response to cytokine  (IEP)
response to drug  (IEP)
response to erythropoietin  (IEP)
response to estradiol  (IDA,IEP)
response to ethanol  (IEP)
response to fluid shear stress  (IEA,ISO)
response to fructose  (IEP)
response to hormone  (IBA)
response to hyperoxia  (IEP)
response to hypoxia  (IEP)
response to ketone  (IEP)
response to L-arginine  (IEP)
response to lead ion  (IEP)
response to lipopolysaccharide  (IBA,IEP)
response to magnetism  (IEP)
response to mechanical stimulus  (IEP)
response to mercury ion  (IEP)
response to metal ion  (IEP)
response to metformin  (IEP)
response to nicotine  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to peptide  (IEP)
response to peptide hormone  (IEP)
response to salt  (IEP)
response to ultrasound  (IEP)
retina development in camera-type eye  (IEP)
signal transduction  (IMP)
smooth muscle hyperplasia  (IEA,ISO)
vasodilation  (ISO)
ventricular septum morphogenesis  (IEA,ISO)

Cellular Component
apical part of cell  (IDA)
caveola  (IDA,IEA,ISO)
cytoplasm  (IDA,ISO)
cytoskeleton  (IEA)
cytosol  (IBA,IDA)
Golgi apparatus  (IDA,IEA,ISO)
membrane raft  (IDA)
mitochondrion  (IDA)
nucleolus  (IDA)
nucleus  (IBA,IDA,IEA,ISO)
plasma membrane  (IBA,IDA,ISO)
sarcolemma  (IDA)
vesicle membrane  (IBA,IDA)

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Additional References at PubMed
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Genomics

Comparative Map Data
Nos3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.047,321,908 - 7,342,404 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,320,668 - 7,342,410 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,333,272 - 7,353,767 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,158,847 - 6,179,441 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.146,158,846 - 6,179,441 (-)NCBI
Celera46,408,408 - 6,428,650 (-)NCBICelera
Cytogenetic Map4q11NCBI
NOS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7150,991,017 - 151,014,588 (+)EnsemblGRCh38hg38GRCh38
GRCh387150,991,017 - 151,014,588 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377150,688,144 - 150,711,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,319,080 - 150,342,609 (+)NCBINCBI36hg18NCBI36
Build 347150,125,794 - 150,149,323NCBI
Celera7145,245,139 - 145,269,020 (+)NCBI
Cytogenetic Map7q36.1NCBI
HuRef7144,500,690 - 144,524,025 (+)NCBIHuRef
CHM1_17150,696,541 - 150,720,093 (+)NCBICHM1_1
CRA_TCAGchr7v27150,017,398 - 150,041,276 (+)NCBI
Nos3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39524,569,772 - 24,589,472 (+)NCBIGRCm39mm39
GRCm38524,364,816 - 24,384,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,364,810 - 24,384,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv37523,870,637 - 23,890,292 (+)NCBIGRCm37mm9NCBIm37
MGSCv36523,874,884 - 23,894,536 (+)NCBImm8
Celera521,311,457 - 21,334,226 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map511.32NCBI
Nos3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,438,010 - 5,460,814 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,438,228 - 5,457,308 (+)NCBIChiLan1.0ChiLan1.0
NOS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17154,730,009 - 154,755,233 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,730,009 - 154,755,233 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07142,577,334 - 142,600,702 (+)NCBIMhudiblu_PPA_v0panPan3
NOS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1615,011,344 - 15,072,277 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11615,054,196 - 15,072,454 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nos3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365276,427,147 - 6,445,770 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,209,156 - 6,228,938 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,209,218 - 6,228,912 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,579,253 - 6,602,572 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOS3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,174,829 - 119,196,840 (+)NCBI
Nos3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248005,600,215 - 5,619,020 (-)NCBI

Position Markers
D4Mgh28  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.047,336,137 - 7,336,282NCBIRnor6.0
Rnor_5.047,347,501 - 7,347,646UniSTSRnor5.0
RGSC_v3.446,172,896 - 6,173,041UniSTSRGSC3.4
RGSC_v3.446,172,895 - 6,173,041RGDRGSC3.4
RGSC_v3.146,172,895 - 6,173,041RGD
Celera46,422,456 - 6,422,601UniSTS
Cytogenetic Map4q11UniSTS
RH 3.4 Map43.2RGD
RH 3.4 Map43.2UniSTS
RH 2.0 Map413.9RGD
PMC155039P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.047,339,328 - 7,339,522NCBIRnor6.0
Rnor_5.047,350,692 - 7,350,886UniSTSRnor5.0
RGSC_v3.446,176,087 - 6,176,281UniSTSRGSC3.4
Celera46,425,647 - 6,425,841UniSTS
Cytogenetic Map4q11UniSTS
RH138584  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.047,341,624 - 7,341,751NCBIRnor6.0
Rnor_5.047,352,987 - 7,353,114UniSTSRnor5.0
RGSC_v3.446,178,665 - 6,178,792UniSTSRGSC3.4
Celera46,427,874 - 6,428,001UniSTS
Cytogenetic Map4q11UniSTS
RH 3.4 Map43.1UniSTS
Nos3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.047,322,498 - 7,322,771NCBIRnor6.0
Rnor_5.047,333,862 - 7,334,135UniSTSRnor5.0
RGSC_v3.446,159,257 - 6,159,530UniSTSRGSC3.4
Celera46,408,818 - 6,409,091UniSTS
Cytogenetic Map4q11UniSTS
UniSTS:166287  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.047,322,848 - 7,323,084NCBIRnor6.0
Rnor_5.047,334,212 - 7,334,448UniSTSRnor5.0
RGSC_v3.446,159,607 - 6,159,843UniSTSRGSC3.4
Celera46,409,168 - 6,409,404UniSTS
Cytogenetic Map4q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4125545519Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4125545519Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4125545519Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4126654881Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4126803291Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4128352196Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4128352196Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4128352196Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4128352196Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4129778604Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4129778604Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4131554484Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)4142118977Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)<