Nos3 (nitric oxide synthase 3) - Rat Genome Database

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Gene: Nos3 (nitric oxide synthase 3) Rattus norvegicus
Symbol: Nos3
Name: nitric oxide synthase 3
RGD ID: 3186
Description: Enables several functions, including Hsp90 protein binding activity; beta-catenin binding activity; and calmodulin binding activity. Involved in several processes, including cellular response to magnesium ion; cellular response to mechanical stimulus; and cellular response to organonitrogen compound. Located in several cellular components, including caveola; nucleolus; and sarcolemma. Used to study artery disease (multiple); irritable bowel syndrome; ischemia (multiple); liver disease (multiple); and retinal disease (multiple). Biomarker of several diseases, including artery disease (multiple); kidney failure (multiple); liver disease (multiple); lung disease (multiple); and overnutrition (multiple). Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); eye disease (multiple); reproductive organ cancer (multiple); and vasculitis (multiple). Orthologous to human NOS3 (nitric oxide synthase 3); PARTICIPATES IN doxorubicin pharmacokinetics pathway; eicosanoid signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH (R)-carnitine; 1,3-dinitrobenzene; 11-deoxycorticosterone.
Type: protein-coding
Previously known as: cNOS; constitutive NOS; EC-NOS; endothelial nitric oxide synthase 3; endothelial NOS; eNos; nitric oxide synthase 3, endothelial cell; nitric oxide synthase, endothelial; NOS type III; NOSIII
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Nos3em2Mcwi   Nos3em8Mcwi   Nos3em13Mcwi  
Genetic Models: SS-Nos3em8Mcwi SS-Nos3em2Mcwi SS-Nos3em13Mcwi
Is Marker For: Strains:   WKY   DA.WF-(D4Mit11-Nos3)/Kop  
QTLs:   Tcas3   BW384_H  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2410,793,834 - 10,814,170 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl410,793,834 - 10,814,166 (-)Ensembl
Rnor_6.047,321,908 - 7,342,404 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,320,668 - 7,342,410 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,333,272 - 7,353,767 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,158,847 - 6,179,441 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.146,158,846 - 6,179,441 (-)NCBI
Celera46,408,408 - 6,428,650 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute chest syndrome  (ISO)
acute kidney failure  (IEP,ISO)
Acute Liver Failure  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 1  (ISO)
angle-closure glaucoma  (ISO)
anterior ischemic optic neuropathy  (ISO)
aortic valve disease  (ISS)
arteriosclerosis  (ISO)
Arteriovenous Fistula  (IEP)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Behcet's disease  (ISO)
bladder neck obstruction  (IEP)
Brain Hypoxia  (IEP)
brain ischemia  (IDA,IMP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (IEP)
Cardiomegaly  (IEP,ISO)
cardiomyopathy  (IEP,ISO)
Cardiotoxicity  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (IEP)
central sleep apnea  (ISO)
cerebral infarction  (ISO)
Child Behavior Disorders  (ISO)
cholestasis  (IEP)
Chronic Cerebral Hypoperfusion  (IMP)
chronic kidney disease  (IEP)
chronic obstructive pulmonary disease  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
colitis  (IEP)
congenital diaphragmatic hernia  (IEP)
congestive heart failure  (IEP,ISO)
coronary artery disease  (ISO)
coronary artery vasospasm  (ISO)
cystic fibrosis  (ISO)
diabetic angiopathy  (IEP,ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Gastroparesis  (IEP)
Diabetic Nephropathies  (IEP,ISO)
diabetic retinopathy  (IDA,IEP,ISO)
Diaphragmatic Hernia  (IEP,ISO)
disease of cellular proliferation  (ISO)
Drug-Induced Enteropathy  (IDA)
end stage renal disease  (IEP,ISO)
endometrial carcinoma  (ISO)
Endotoxemia  (IEP)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
essential hypertension  (ISO)
Experimental Arthritis  (IEP)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
extrahepatic cholestasis  (ISO)
familial hyperlipidemia  (IEP,ISO)
Fetal Growth Retardation  (IEP,ISO)
gastric ulcer  (IEP,ISO)
Graft Occlusion, Vascular  (ISO)
Hemorrhagic Shock  (IEP)
Hepatic Insufficiency  (ISO)
Hepatomegaly  (ISO)
hepatopulmonary syndrome  (IEP)
high grade glioma  (ISO)
Huntington's disease  (IEP)
Hyperemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxia  (IEP)
hypertension  (IDA,IEP,ISO)
Hypertension Resistant to Conventional Therapy  (ISO)
Hypertriglyceridemia  (IEP)
hypothyroidism  (IEP)
Hypoxia  (ISO)
ileus  (IEP)
impotence  (IEP,ISO)
Insulin Resistance  (IEP,ISO)
intestinal perforation  (ISO)
Intestinal Reperfusion Injury  (IDA)
Intimal Hyperplasia  (ISO)
intracranial aneurysm  (IEP,ISO)
Intracranial Hemorrhages  (IMP)
irritable bowel syndrome  (IDA)
ischemia  (ISO)
Kidney Reperfusion Injury  (IEP)
Kuhnt-Junius degeneration  (ISO)
Left Ventricular Hypertrophy  (IEP)
leiomyoma  (ISO)
lethal congenital glycogen storage disease of heart  (ISO)
Limb Ischemia  (IDA,IEP,ISO)
liver cirrhosis  (IDA,IEP)
Liver Reperfusion Injury  (IEP)
long QT syndrome  (ISO)
lung disease  (IEP,ISO)
Lung Reperfusion Injury  (IMP,ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
macular retinal edema  (ISO)
male infertility  (ISO)
Metabolic Syndrome  (IDA,IMP,ISO)
migraine  (ISO)
myocardial infarction  (IDA,IEP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IDA,IEP,IMP,ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
obesity  (IEP)
obstructive sleep apnea  (ISO)
oligospermia  (ISO)
ovarian cancer  (ISO)
overnutrition  (IEP)
Pain  (IMP)
Perennial Allergic Rhinitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
persistent fetal circulation syndrome  (ISS)
Phyllodes Tumor  (ISO)
placental abruption  (ISO)
polycystic kidney disease  (IEP)
portal hypertension  (IDA,IEP,ISO)
pre-eclampsia  (IEP,ISO)
Preeclampsia/Eclampsia 1  (ISO)
Pregnancy-Induced Hypertension  (ISO)
primary biliary cholangitis  (ISO)
primary open angle glaucoma  (ISO)
primary ovarian insufficiency  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary edema  (IEP,ISO)
pulmonary embolism  (IEP)
pulmonary emphysema  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary hypertension  (IDA,IEP,IMP,ISO)
Pulmonary Hypertension, Hypoxia-Induced  (IEP)
Radiation Pneumonitis  (ISO)
renal hypertension  (IDA)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Retina Reperfusion Injury  (IDA,IEP)
retinal degeneration  (IDA,IEP)
retinopathy of prematurity  (ISO)
Right Ventricular Hypertrophy  (IDA)
Sepsis  (ISO)
sickle cell anemia  (ISO)
Spinal Cord Compression  (IEP)
Spinal Cord Injuries  (IEP)
Stomach Neoplasms  (ISO)
Stroke  (IEP,ISO)
Subarachnoid Hemorrhage  (IEP)
Sudden Hearing Loss  (ISO)
telangiectasis  (ISO)
Teratozoospermia  (ISO)
Testis Reperfusion Injury  (IEP)
Thromboembolism  (ISO)
Thrombotic Microangiopathies  (IEP)
transient cerebral ischemia  (IDA,IEP)
Transplant Rejection  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
vasculitis  (ISO)
Vaso-occlusive Crisis  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Right  (IMP)
Ventricular Premature Complexes  (ISO)
Ventricular Tachycardia  (ISO)
vestibular disease  (ISO)
vulva cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
11-deoxycorticosterone  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic GMP  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3-diphenyl-N-(1-phenylethyl)-1-propanamine  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
5,6,7,8-tetrahydrobiopterin  (ISO)
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
9,10-phenanthroquinone  (ISO)
acetylcholine  (EXP,ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
AICA ribonucleotide  (EXP)
alcohol  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldrin  (ISO)
alkaloid  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
allopurinol  (EXP)
alpha-hexachlorocyclohexane  (ISO)
alpha-Zearalanol  (ISO)
aminoguanidine  (ISO)
amiodarone  (ISO)
amlodipine  (EXP)
ammonium chloride  (EXP)
anagliptin  (ISO)
apocynin  (EXP,ISO)
aristolochic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
atrasentan  (EXP)
atrazine  (ISO)
axitinib  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
benzoic acid  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
Calcimycin  (EXP,ISO)
calciol  (EXP)
calcitriol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calmidazolium  (EXP)
camostat  (EXP)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
Cardamonin  (EXP)
carvedilol  (EXP)
cetirizine  (ISO)
chelerythrine  (EXP)
chlorogenic acid  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
chrysin  (EXP)
cilostazol  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP)
cloricromen  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (ISO)
curcumin  (ISO)
cyanidin cation  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
Decursin  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dichlorine  (EXP)
digitoxin  (ISO)
digoxin  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP,ISO)
elemental selenium  (ISO)
enalapril  (EXP,ISO)
endosulfan  (EXP,ISO)
enzyme inhibitor  (EXP)
eplerenone  (EXP)
equol  (ISO)
erucic acid  (EXP)
esculetin  (EXP)
estriol  (ISO)
ethanol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
everolimus  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
Fexofenadine hydrochloride  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
fluorene  (ISO)
flutamide  (EXP)
fluvastatin  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
formic acid  (EXP)
formononetin  (EXP)
fosinopril  (EXP)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
furosemide  (EXP)
genistein  (ISO)
gentamycin  (EXP,ISO)
ginsenoside Re  (ISO)
Ginsenoside Rg5  (EXP)
gliclazide  (EXP)
glucose  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
GW 501516  (ISO)
hemin  (EXP)
hexachlorobenzene  (EXP,ISO)
hexacosan-1-ol  (EXP)
hexadecanoic acid  (EXP,ISO)
high-density lipoprotein cholesterol  (ISO)
histamine  (EXP)
homocysteine  (ISO)
hydrochlorothiazide  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
icariin  (EXP,ISO)
indometacin  (EXP,ISO)
iron dextran  (EXP,ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
isosorbide dinitrate  (ISO)
L-arginine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-erythro-7,8-dihydrobiopterin  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
lead(II) chloride  (ISO)
levamisole  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
luteolin  (EXP)
LY294002  (EXP,ISO)
lysophosphatidylcholine  (EXP)
Magnolol  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
manidipine  (EXP)
masoprocol  (ISO)
medroxyprogesterone acetate  (EXP,ISO)
melatonin  (ISO)
menadione  (EXP)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methacholine chloride  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
metoprolol  (EXP)
mifepristone  (ISO)
miquelianin  (ISO)
monocrotaline  (EXP)
myricitrin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-desethylamiodarone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naphthalene  (ISO)
nebivolol  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicorandil  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP,ISO)
nifedipine  (ISO)
nitrates  (EXP)
nitric oxide  (EXP,ISO)
nitrites  (EXP,ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
nitroglycerin  (EXP)
nitroprusside  (ISO)
notoginsenoside R1  (ISO)
oleic acid  (ISO)
olmesartan  (EXP)
orotic acid  (ISO)
orphenadrine  (EXP)
Osajin  (ISO)
ouabain  (EXP)
ozone  (EXP)
paclitaxel  (ISO)
palytoxin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
paricalcitol  (ISO)
PD123319  (ISO)
pentaerythritol tetranitrate  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
peroxynitrous acid  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phloretin  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphane  (EXP)
picoxystrobin  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP)
plerixafor  (ISO)
Pomiferin  (ISO)
potassium chloride  (EXP,ISO)
pravastatin  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
propazine  (ISO)
propranolol  (EXP)
protoporphyrin  (ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (EXP)
rac-lactic acid  (ISO)
raloxifene  (EXP)
ramipril  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
Rosavin  (ISO)
rosmarinic acid  (EXP)
rosuvastatin calcium  (EXP,ISO)
rotenone  (ISO)
roxarsone  (ISO)
salicylic acid  (EXP)
salsalate  (EXP)
sapropterin  (ISO)
sarpogrelate  (EXP)
SB 203580  (ISO)
scutellarin  (EXP)
selenium atom  (ISO)
sepiapterin  (ISO)
sibutramine  (ISO)
sildenafil citrate  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simazine  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium azide  (ISO)
sodium chloride  (EXP)
sodium nitrate  (ISO)
Sodium salicylate  (ISO)
Soman  (EXP)
sorafenib  (EXP)
stilbenoid  (ISO)
streptozocin  (EXP)
sucrose  (EXP)
sulfur dioxide  (ISO)
superoxide  (EXP,ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (ISO)
tangeretin  (EXP)
Tanshinone I  (EXP,ISO)
tebufenpyrad  (ISO)
telmisartan  (ISO)
tenofovir disoproxil fumarate  (ISO)
terbutylazine  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (ISO)
tetramethylpyrazine  (ISO)
theaflavin  (ISO)
thioacetamide  (EXP)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (ISO)
torcetrapib  (EXP,ISO)
trans-caffeic acid  (ISO)
trans-cinnamic acid  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
ubiquinones  (ISO)
udenafil  (EXP)
uranium atom  (EXP)
urethane  (ISO)
ursolic acid  (ISO)
valsartan  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vanillic acid  (ISO)
vitamin E  (EXP,ISO)
wortmannin  (EXP,ISO)
Y-27632  (ISO)
zidovudine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zolmitriptan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
angiogenesis  (IEA,ISO)
aortic valve morphogenesis  (IEA,ISO)
arginine catabolic process  (IBA,IEA,ISO)
blood vessel diameter maintenance  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
bone development  (IEP)
calcium ion transport  (IEA,ISO)
cellular response to cAMP  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to heat  (IEP)
cellular response to high density lipoprotein particle stimulus  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to low-density lipoprotein particle stimulus  (IEP)
cellular response to magnesium ion  (IEP)
cellular response to mechanical stimulus  (IMP)
cellular response to organic cyclic compound  (IEP)
cellular response to rotenone  (IEP)
cellular response to transforming growth factor beta stimulus  (IMP)
cellular response to tumor necrosis factor  (IEP)
endocardial cushion morphogenesis  (IEA,ISO)
endothelial cell migration  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
female pregnancy  (IEP)
homeostasis of number of cells within a tissue  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
lung development  (IEA,ISO)
negative regulation of biomineral tissue development  (IEA,ISO)
negative regulation of blood pressure  (IBA)
negative regulation of calcium ion transport  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of hydrolase activity  (IEA,ISO)
negative regulation of muscle hyperplasia  (IEA,ISO)
negative regulation of potassium ion transport  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (IEA,IMP,ISO)
nitric oxide biosynthetic process  (IBA,IEA,IEP,IMP,ISO)
nitric oxide mediated signal transduction  (IBA)
ovulation from ovarian follicle  (IEA,ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of guanylate cyclase activity  (IBA,IEA,ISO)
potassium ion transport  (IEA,ISO)
pulmonary valve morphogenesis  (IEA,ISO)
regulation of apoptotic process  (IEA)
regulation of nervous system process  (IEA,ISO)
regulation of sodium ion transport  (IEA,ISO)
regulation of systemic arterial blood pressure by endothelin  (IEA,ISO)
regulation of the force of heart contraction by chemical signal  (IEA,ISO)
removal of superoxide radicals  (IEA,ISO)
response to activity  (IEP)
response to amino acid  (IEP)
response to axon injury  (IEP)
response to candesartan  (IEP)
response to carbohydrate  (IEP)
response to corticosterone  (IEP)
response to cytokine  (IEP)
response to erythropoietin  (IEP)
response to estradiol  (IDA,IEP)
response to ethanol  (IEP)
response to fluid shear stress  (IEA,ISO)
response to fructose  (IEP)
response to hormone  (IBA)
response to hyperoxia  (IEP)
response to hypoxia  (IEP)
response to ketone  (IEP)
response to L-arginine  (IEP)
response to lead ion  (IEP)
response to lipopolysaccharide  (IBA,IEP)
response to magnetism  (IEP)
response to mechanical stimulus  (IEP)
response to mercury ion  (IEP)
response to metal ion  (IEP)
response to metformin  (IEP)
response to nicotine  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to peptide  (IEP)
response to peptide hormone  (IEP)
response to salt  (IEP)
response to ultrasound  (IEP)
response to xenobiotic stimulus  (IEP)
retina development in camera-type eye  (IEP)
signal transduction  (IMP)
smooth muscle hyperplasia  (IEA,ISO)
vasodilation  (ISO)
ventricular septum morphogenesis  (IEA,ISO)

Cellular Component
apical part of cell  (IDA)
caveola  (IDA,IEA,ISO)
cytoplasm  (IDA,ISO)
cytoskeleton  (IEA)
cytosol  (IBA,IDA)
Golgi apparatus  (IDA,IEA,ISO)
membrane raft  (IDA)
mitochondrion  (IDA)
nucleolus  (IDA)
nucleus  (IBA,IDA,IEA,ISO)
plasma membrane  (IBA,IDA,ISO)
sarcolemma  (IDA)
vesicle membrane  (IBA,IDA)

Molecular Function


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