Nos3 (nitric oxide synthase 3) - Rat Genome Database

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Gene: Nos3 (nitric oxide synthase 3) Rattus norvegicus
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Symbol: Nos3
Name: nitric oxide synthase 3
RGD ID: 3186
Description: Enables several functions, including Hsp90 protein binding activity; beta-catenin binding activity; and calmodulin binding activity. Involved in several processes, including cellular response to cAMP; cellular response to magnesium ion; and cellular response to mechanical stimulus. Located in several cellular components, including apical part of cell; caveola; and sarcolemma. Used to study artery disease (multiple); irritable bowel syndrome; ischemia (multiple); liver disease (multiple); and retinal disease (multiple). Biomarker of several diseases, including artery disease (multiple); kidney failure (multiple); liver disease (multiple); lung disease (multiple); and overnutrition (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); eye disease (multiple); leukemia (multiple); reproductive organ cancer (multiple); and vasculitis (multiple). Orthologous to human NOS3 (nitric oxide synthase 3); PARTICIPATES IN doxorubicin pharmacokinetics pathway; eicosanoid signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH (R)-carnitine; 1,3-dinitrobenzene; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cNOS; constitutive NOS; EC-NOS; endothelial nitric oxide synthase 3; endothelial NOS; eNos; nitric oxide synthase 3, endothelial cell; nitric oxide synthase, endothelial; NOS type III; NOSIII
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nos3em2Mcwi   Nos3em8Mcwi   Nos3em13Mcwi  
Genetic Models: SS-Nos3em8Mcwi SS-Nos3em2Mcwi SS-Nos3em13Mcwi
Is Marker For: Strains:   WKY   DA.WF-(D4Mit11-Nos3)/Kop  
QTLs:   Tcas3   BW384_H  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,686,088 - 11,706,604 (-)NCBIGRCr8
mRatBN7.2410,793,834 - 10,814,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,793,834 - 10,814,166 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,940,095 - 15,960,412 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,760,284 - 11,780,599 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,112,074 - 10,132,387 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,321,908 - 7,342,404 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,320,668 - 7,342,410 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,333,272 - 7,353,767 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,158,847 - 6,179,441 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,158,846 - 6,179,441 (-)NCBI
Celera46,408,408 - 6,428,650 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute chest syndrome  (ISO)
acute kidney failure  (IEP,ISO)
Acute Liver Failure  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 1  (ISO)
angle-closure glaucoma  (ISO)
anterior ischemic optic neuropathy  (ISO)
aortic valve disease  (ISS)
arteriosclerosis  (ISO)
Arteriovenous Fistula  (IEP)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
autism spectrum disorder  (ISO)
Behcet's disease  (ISO)
bladder neck obstruction  (IEP)
Brain Hypoxia  (IEP)
brain ischemia  (IDA,IMP)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (IEP)
Cardiomegaly  (IEP,ISO)
cardiomyopathy  (IEP,ISO)
Cardiotoxicity  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (IEP)
central sleep apnea  (ISO)
cerebral infarction  (ISO)
Child Behavior Disorders  (ISO)
cholestasis  (IEP)
Chronic Cerebral Hypoperfusion  (IMP)
chronic kidney disease  (IEP)
chronic obstructive pulmonary disease  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
colitis  (IEP)
congenital diaphragmatic hernia  (IEP)
congestive heart failure  (IEP,ISO)
coronary artery disease  (ISO)
coronary artery vasospasm  (ISO)
cystic fibrosis  (ISO)
diabetic angiopathy  (IEP,ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Gastroparesis  (IEP)
Diabetic Nephropathies  (IEP,ISO)
diabetic retinopathy  (IDA,IEP,ISO)
Diaphragmatic Hernia  (IEP,ISO)
disease of cellular proliferation  (ISO)
Drug-Induced Enteropathy  (IDA)
end stage renal disease  (IEP,ISO)
endometrial carcinoma  (ISO)
Endotoxemia  (IEP)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
essential hypertension  (ISO,ISS)
Experimental Arthritis  (IEP)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
extrahepatic cholestasis  (ISO)
familial hyperlipidemia  (IEP,ISO)
Femur Head Necrosis  (ISO)
Fetal Growth Retardation  (IEP,ISO)
gastric ulcer  (IEP,ISO)
Graft Occlusion, Vascular  (ISO)
Hemorrhagic Shock  (IEP)
Hepatic Insufficiency  (ISO)
Hepatomegaly  (ISO)
hepatopulmonary syndrome  (IEP)
high grade glioma  (ISO)
Huntington's disease  (IEP)
Hyperemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxia  (IEP)
hypertension  (IDA,IEP,ISO)
Hypertension Resistant to Conventional Therapy  (ISO)
Hypertriglyceridemia  (IEP)
hypothyroidism  (IEP)
Hypoxia  (ISO)
ileus  (IEP)
impotence  (IEP,ISO)
Insulin Resistance  (IEP,ISO)
intestinal perforation  (ISO)
Intestinal Reperfusion Injury  (IDA)
Intimal Hyperplasia  (ISO)
intracranial aneurysm  (IEP,ISO)
Intracranial Hemorrhages  (IMP)
irritable bowel syndrome  (IDA)
ischemia  (ISO)
Kidney Reperfusion Injury  (IEP)
Kuhnt-Junius degeneration  (ISO)
Left Ventricular Hypertrophy  (IEP)
leiomyoma  (ISO)
lethal congenital glycogen storage disease of heart  (ISO)
limb ischemia  (IDA,IEP,ISO)
liver cirrhosis  (IDA,IEP)
Liver Reperfusion Injury  (IEP)
long QT syndrome  (ISO)
lung disease  (IEP,ISO)
Lung Reperfusion Injury  (IMP,ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
macular retinal edema  (ISO)
male infertility  (ISO)
Metabolic Syndrome  (IDA,IMP,ISO)
migraine  (ISO)
myocardial infarction  (IDA,IEP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IDA,IEP,IMP,ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
obesity  (IEP)
obstructive sleep apnea  (ISO)
oligospermia  (ISO)
ovarian cancer  (ISO)
overnutrition  (IEP)
Pain  (IMP)
Perennial Allergic Rhinitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
persistent fetal circulation syndrome  (ISS)
Phyllodes Tumor  (ISO)
placental abruption  (ISO)
polycystic kidney disease  (IEP)
portal hypertension  (IDA,IEP,ISO)
pre-eclampsia  (IEP,ISO)
Pregnancy-Induced Hypertension  (ISO)
Prenatal Exposure Delayed Effects  (IEP)
primary biliary cholangitis  (IEP,ISO)
primary open angle glaucoma  (ISO)
primary ovarian insufficiency  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary edema  (IEP,ISO)
pulmonary embolism  (IEP)
pulmonary emphysema  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary hypertension  (IDA,IEP,IMP,ISO)
Pulmonary Hypertension, Hypoxia-Induced  (IEP)
Radiation Pneumonitis  (ISO)