Nos3 (nitric oxide synthase 3) - Rat Genome Database

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Gene: Nos3 (nitric oxide synthase 3) Rattus norvegicus
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Symbol: Nos3
Name: nitric oxide synthase 3
RGD ID: 3186
Description: Enables several functions, including Hsp90 protein binding activity; beta-catenin binding activity; and calmodulin binding activity. Involved in several processes, including cellular response to magnesium ion; cellular response to mechanical stimulus; and cellular response to organonitrogen compound. Located in several cellular components, including apical part of cell; caveola; and sarcolemma. Used to study artery disease (multiple); irritable bowel syndrome; ischemia (multiple); liver disease (multiple); and retinal disease (multiple). Biomarker of several diseases, including artery disease (multiple); kidney failure (multiple); liver disease (multiple); lung disease (multiple); and overnutrition (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); eye disease (multiple); leukemia (multiple); reproductive organ cancer (multiple); and vasculitis (multiple). Orthologous to human NOS3 (nitric oxide synthase 3); PARTICIPATES IN doxorubicin pharmacokinetics pathway; eicosanoid signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH (R)-carnitine; 1,3-dinitrobenzene; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cNOS; constitutive NOS; EC-NOS; endothelial nitric oxide synthase 3; endothelial NOS; eNos; nitric oxide synthase 3, endothelial cell; nitric oxide synthase, endothelial; NOS type III; NOSIII
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Nos3em2Mcwi   Nos3em8Mcwi   Nos3em13Mcwi  
Genetic Models: SS-Nos3em8Mcwi SS-Nos3em2Mcwi SS-Nos3em13Mcwi
Is Marker For: Strains:   WKY   DA.WF-(D4Mit11-Nos3)/Kop  
QTLs:   Tcas3   BW384_H  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2410,793,834 - 10,814,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,793,834 - 10,814,166 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,940,095 - 15,960,412 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,760,284 - 11,780,599 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,112,074 - 10,132,387 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,321,908 - 7,342,404 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,320,668 - 7,342,410 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,333,272 - 7,353,767 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,158,847 - 6,179,441 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,158,846 - 6,179,441 (-)NCBI
Celera46,408,408 - 6,428,650 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute chest syndrome  (ISO)
acute kidney failure  (IEP,ISO)
Acute Liver Failure  (IEP)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 1  (ISO)
angle-closure glaucoma  (ISO)
anterior ischemic optic neuropathy  (ISO)
aortic valve disease  (ISS)
arteriosclerosis  (ISO)
Arteriovenous Fistula  (IEP)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
autism spectrum disorder  (ISO)
Behcet's disease  (ISO)
bladder neck obstruction  (IEP)
Brain Hypoxia  (IEP)
brain ischemia  (IDA,IMP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (IEP)
Cardiomegaly  (IEP,ISO)
cardiomyopathy  (IEP,ISO)
Cardiotoxicity  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (IEP)
central sleep apnea  (ISO)
cerebral infarction  (ISO)
Child Behavior Disorders  (ISO)
cholestasis  (IEP)
Chronic Cerebral Hypoperfusion  (IMP)
chronic kidney disease  (IEP)
chronic obstructive pulmonary disease  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
colitis  (IEP)
congenital diaphragmatic hernia  (IEP)
congestive heart failure  (IEP,ISO)
coronary artery disease  (ISO)
coronary artery vasospasm  (ISO)
cystic fibrosis  (ISO)
diabetic angiopathy  (IEP,ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Gastroparesis  (IEP)
Diabetic Nephropathies  (IEP,ISO)
diabetic retinopathy  (IDA,IEP,ISO)
Diaphragmatic Hernia  (IEP,ISO)
disease of cellular proliferation  (ISO)
Drug-Induced Enteropathy  (IDA)
end stage renal disease  (IEP,ISO)
endometrial carcinoma  (ISO)
Endotoxemia  (IEP)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
essential hypertension  (ISO,ISS)
Experimental Arthritis  (IEP)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Experimental Liver Cirrhosis  (IEP,ISO)
extrahepatic cholestasis  (ISO)
familial hyperlipidemia  (IEP,ISO)
Femur Head Necrosis  (ISO)
Fetal Growth Retardation  (IEP,ISO)
gastric ulcer  (IEP,ISO)
genetic disease  (ISO)
Graft Occlusion, Vascular  (ISO)
Hemorrhagic Shock  (IEP)
Hepatic Insufficiency  (ISO)
Hepatomegaly  (ISO)
hepatopulmonary syndrome  (IEP)
high grade glioma  (ISO)
Huntington's disease  (IEP)
Hyperemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxia  (IEP)
hypertension  (IDA,IEP,ISO)
Hypertension Resistant to Conventional Therapy  (ISO)
Hypertriglyceridemia  (IEP)
hypothyroidism  (IEP)
Hypoxia  (ISO)
ileus  (IEP)
impotence  (IEP,ISO)
Insulin Resistance  (IEP,ISO)
intestinal perforation  (ISO)
Intestinal Reperfusion Injury  (IDA)
Intimal Hyperplasia  (ISO)
intracranial aneurysm  (IEP,ISO)
Intracranial Hemorrhages  (IMP)
irritable bowel syndrome  (IDA)
ischemia  (ISO)
Kidney Reperfusion Injury  (IEP)
Kuhnt-Junius degeneration  (ISO)
Left Ventricular Hypertrophy  (IEP)
leiomyoma  (ISO)
lethal congenital glycogen storage disease of heart  (ISO)
limb ischemia  (IDA,IEP,ISO)
liver cirrhosis  (IDA,IEP)
Liver Reperfusion Injury  (IEP)
long QT syndrome  (ISO)
lung disease  (IEP,ISO)
Lung Reperfusion Injury  (IMP,ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
macular retinal edema  (ISO)
male infertility  (ISO)
Metabolic Syndrome  (IDA,IMP,ISO)
migraine  (ISO)
myocardial infarction  (IDA,IEP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IDA,IEP,IMP,ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
obesity  (IEP)
obstructive sleep apnea  (ISO)
oligospermia  (ISO)
ovarian cancer  (ISO)
overnutrition  (IEP)
Pain  (IMP)
Perennial Allergic Rhinitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
persistent fetal circulation syndrome  (ISS)
Phyllodes Tumor  (ISO)
placental abruption  (ISO)
polycystic kidney disease  (IEP)
portal hypertension  (IDA,IEP,ISO)
pre-eclampsia  (IEP,ISO)
Pregnancy-Induced Hypertension  (ISO)
Prenatal Exposure Delayed Effects  (IEP)
primary biliary cholangitis  (IEP,ISO)
primary open angle glaucoma  (ISO)
primary ovarian insufficiency  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary edema  (IEP,ISO)
pulmonary embolism  (IEP)
pulmonary emphysema  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary hypertension  (IDA,IEP,IMP,ISO)
Pulmonary Hypertension, Hypoxia-Induced  (IEP)
Radiation Pneumonitis  (ISO)
renal hypertension  (IDA)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Retina Reperfusion Injury  (IDA,IEP)
retinal degeneration  (IDA,IEP)
retinopathy of prematurity  (ISO)
Right Ventricular Hypertrophy  (IDA)
Sepsis  (ISO)
sickle cell anemia  (ISO)
Spinal Cord Compression  (IEP)
Spinal Cord Injuries  (IEP)
Stomach Neoplasms  (ISO)
Stroke  (IEP,ISO)
Subarachnoid Hemorrhage  (IEP)
Sudden Hearing Loss  (ISO)
telangiectasis  (ISO)
Teratozoospermia  (ISO)
Testis Reperfusion Injury  (IEP)
Thromboembolism  (ISO)
Thrombotic Microangiopathies  (IEP)
transient cerebral ischemia  (IDA,IEP)
Transplant Rejection  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
vasculitis  (ISO)
Vaso-occlusive Crisis  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Right  (IMP)
Ventricular Premature Complexes  (ISO)
Ventricular Tachycardia  (ISO)
vestibular disease  (ISO)
vulva cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
11-deoxycorticosterone  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic GMP  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3-diphenyl-N-(1-phenylethyl)-1-propanamine  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
5,6,7,8-tetrahydrobiopterin  (ISO)
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
5-methoxypsoralen  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
9,10-phenanthroquinone  (ISO)
acetylcholine  (EXP,ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
agmatine  (ISO)
AICA ribonucleotide  (EXP)
alcohol  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldrin  (ISO)
alkaloid  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
allopurinol  (EXP)
alpha-hexachlorocyclohexane  (ISO)
alpha-Zearalanol  (ISO)
aminoguanidine  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
anagliptin  (ISO)
ANTU  (EXP)
apocynin  (EXP,ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrasentan  (EXP)
atrazine  (EXP,ISO)
axitinib  (ISO)
azoxystrobin  (ISO)
BAPTA  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
benzoic acid  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bosentan  (EXP)
bradykinin  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
Calcimycin  (EXP,ISO)
calciol  (EXP)
calcitriol  (EXP)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calmidazolium  (EXP)
camostat  (EXP)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
Cardamonin  (EXP)
carvedilol  (EXP,ISO)
cetirizine  (ISO)
chelerythrine  (EXP)
chlorogenic acid  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
chrysin  (EXP)
cilostazol  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP)
cloricromen  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (ISO)
cordycepin  (ISO)
curcumin  (ISO)
cyanidin cation  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
DDE  (ISO)
Decursin  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
digitoxin  (ISO)
digoxin  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP,ISO)
elemental selenium  (ISO)
enalapril  (EXP,ISO)
endosulfan  (EXP,ISO)
enzyme inhibitor  (EXP)
eplerenone  (EXP)
equol  (ISO)
erucic acid  (EXP)
esculetin  (EXP)
estriol  (ISO)
ethanol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
everolimus  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
Fexofenadine hydrochloride  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
fluorene  (ISO)
flutamide  (EXP)
fluvastatin  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
formic acid  (EXP)
formononetin  (EXP)
fosinopril  (EXP)
fructose  (EXP,ISO)
fulvestrant  (EXP,ISO)
furosemide  (EXP)
genistein  (ISO)
gentamycin  (EXP,ISO)
ginsenoside Re  (ISO)
Ginsenoside Rg5  (EXP)
gliclazide  (EXP)
glucose  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
GW 501516  (ISO)
hemin  (EXP)
hexachlorobenzene  (EXP,ISO)
hexacosan-1-ol  (EXP)
hexadecanoic acid  (EXP,ISO)
high-density lipoprotein cholesterol  (ISO)
histamine  (EXP)
homocysteine  (ISO)
hydrochlorothiazide  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
icariin  (EXP,ISO)
indometacin  (EXP,ISO)
iron dextran  (EXP,ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
isosorbide dinitrate  (ISO)
kaempferol  (EXP)
ketoconazole  (EXP)
L-arginine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-erythro-7,8-dihydrobiopterin  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lead(II) chloride  (ISO)
levamisole  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
luteolin  (EXP)
LY294002  (EXP,ISO)
lysophosphatidylcholine  (EXP)
Magnolol  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
manidipine  (EXP)
masoprocol  (ISO)
medroxyprogesterone acetate  (EXP,ISO)
melatonin  (ISO)
menadione  (EXP)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methacholine chloride  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
metoprolol  (EXP)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
miquelianin  (ISO)
MK-2206  (EXP)
monocrotaline  (EXP)
myricitrin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-desethylamiodarone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naphthalene  (ISO)
nebivolol  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicorandil  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP,ISO)
nifedipine  (ISO)
nitrates  (EXP)
nitric oxide  (EXP,ISO)
nitrites  (EXP,ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
nitroglycerin  (EXP)
nitroprusside  (ISO)
notoginsenoside R1  (ISO)
oleic acid  (ISO)
olmesartan  (EXP)
orotic acid  (ISO)
orphenadrine  (EXP)
Osajin  (ISO)
ouabain  (EXP)
ozone  (EXP)
paclitaxel  (ISO)
palytoxin  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
paricalcitol  (ISO)
PD123319  (ISO)
pentaerythritol tetranitrate  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
peroxynitrous acid  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phloretin  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphane  (EXP)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP)
plerixafor  (ISO)
Pomiferin  (ISO)
potassium chloride  (EXP,ISO)
pravastatin  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
propazine  (ISO)
propiconazole  (EXP)
propranolol  (EXP)
protoporphyrin  (ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
quinapril hydrochloride  (EXP)
rac-lactic acid  (ISO)
raloxifene  (EXP)
ramipril  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
Rosavin  (ISO)
rosmarinic acid  (EXP)
rosuvastatin calcium  (EXP,ISO)
rotenone  (ISO)
roxarsone  (ISO)
salicylic acid  (EXP)
salsalate  (EXP)
sapropterin  (ISO)
sarpogrelate  (EXP)
SB 203580  (ISO)
scutellarin  (EXP)
selenium atom  (ISO)
sepiapterin  (ISO)
sibutramine  (ISO)
sildenafil citrate  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simazine  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium azide  (ISO)
sodium chloride  (EXP)
sodium nitrate  (ISO)
Sodium salicylate  (ISO)
Soman  (EXP)
sorafenib  (EXP)
stilbenoid  (ISO)
streptozocin  (EXP)
sucrose  (EXP)
sulfadimethoxine  (EXP)
sulfur dioxide  (ISO)
superoxide  (EXP,ISO)
T-2 toxin  (ISO)
tacrolimus (anhydrous)  (ISO)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (ISO)
tangeretin  (EXP)
Tanshinone I  (EXP,ISO)
tebufenpyrad  (ISO)
telmisartan  (ISO)
tenofovir disoproxil fumarate  (ISO)
terbutylazine  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (ISO)
tetramethylpyrazine  (ISO)
theaflavin  (ISO)
thioacetamide  (EXP)
thymoquinone  (EXP)
thyroxine  (EXP)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (ISO)
torcetrapib  (EXP,ISO)
trans-caffeic acid  (ISO)
trans-cinnamic acid  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
ubiquinones  (ISO)
udenafil  (EXP)
uranium atom  (EXP)
urethane  (ISO)
ursolic acid  (ISO)
valsartan  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vanillic acid  (ISO)
vitamin E  (EXP,ISO)
wortmannin  (EXP,ISO)
Y-27632  (ISO)
zidovudine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zolmitriptan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
aortic valve morphogenesis  (IEA,ISO)
arginine catabolic process  (IBA,IEA,ISO)
blood vessel diameter maintenance  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
bone development  (IEP)
calcium ion transport  (IEA,ISO)
cellular response to cAMP  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to heat  (IEP)
cellular response to high density lipoprotein particle stimulus  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to low-density lipoprotein particle stimulus  (IEP)
cellular response to magnesium ion  (IEP)
cellular response to mechanical stimulus  (IMP)
cellular response to organic cyclic compound  (IEP)
cellular response to rotenone  (IEP)
cellular response to transforming growth factor beta stimulus  (IMP)
cellular response to tumor necrosis factor  (IEP)
endocardial cushion morphogenesis  (IEA,ISO)
endothelial cell migration  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
female pregnancy  (IEP)
homeostasis of number of cells within a tissue  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
lung development  (IEA,ISO)
negative regulation of biomineral tissue development  (IEA,ISO)
negative regulation of blood pressure  (IBA)
negative regulation of calcium ion transport  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of muscle hyperplasia  (IEA,ISO)
negative regulation of potassium ion transport  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (IEA,IMP,ISO)
nitric oxide biosynthetic process  (IBA,IEA,IEP,IMP,ISO)
nitric oxide mediated signal transduction  (IBA)
nitric oxide metabolic process  (IEP)
ovulation from ovarian follicle  (IEA,ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
potassium ion transport  (IEA,ISO)
pulmonary valve morphogenesis  (IEA,ISO)
regulation of nervous system process  (IEA,ISO)
regulation of sodium ion transport  (IEA,ISO)
regulation of systemic arterial blood pressure by endothelin  (IEA,ISO)
regulation of the force of heart contraction by chemical signal  (IEA,ISO)
removal of superoxide radicals  (IEA,ISO)
response to activity  (IEP)
response to amino acid  (IEP)
response to axon injury  (IEP)
response to carbohydrate  (IEP)
response to corticosterone  (IEP)
response to cytokine  (IEP)
response to erythropoietin  (IEP)
response to estradiol  (IDA,IEP)
response to ethanol  (IEP)
response to fluid shear stress  (IEA,ISO)
response to fructose  (IEP)
response to hormone  (IBA)
response to hyperoxia  (IEP)
response to hypoxia  (IEP)
response to ketone  (IEP)
response to L-arginine  (IEP)
response to lead ion  (IEP)
response to lipopolysaccharide  (IBA,IEP)
response to magnetism  (IEP)
response to mechanical stimulus  (IEP)
response to mercury ion  (IEP)
response to metal ion  (IEP)
response to nicotine  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to peptide  (IEP)
response to peptide hormone  (IEP)
response to salt  (IEP)
response to ultrasound  (IEP)
response to xenobiotic stimulus  (IEP)
retina development in camera-type eye  (IEP)
smooth muscle hyperplasia  (IEA,ISO)
vasodilation  (ISO)
ventricular septum morphogenesis  (IEA,ISO)

Cellular Component
apical part of cell  (IDA)
caveola  (IDA,IEA,ISO)
cytoplasm  (IDA,ISO)
cytoskeleton  (IEA)
cytosol  (IBA)
Golgi apparatus  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)
plasma membrane  (IBA,ISO)
sarcolemma  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Time-related changes in constitutive and inducible nitric oxide synthases in the rat striatum in a model of Huntington's disease. Aguilera P, etal., Neurotoxicology. 2007 Nov;28(6):1200-7. Epub 2007 Aug 6.
2. Nicorandil and theophylline can protect experimental rats against complete Freund's adjuvant-induced rheumatoid arthritis through modulation of JAK/STAT/RANKL signaling pathway. Ahmed Gaafar AG, etal., Eur J Pharmacol. 2018 Jan 11. pii: S0014-2999(18)30015-3. doi: 10.1016/j.ejphar.2018.01.009.
3. Endothelial-derived vasoactive mediators in polycystic kidney disease. Al-Nimri MA, etal., Kidney Int. 2003 May;63(5):1776-84.
4. Endothelial NOS expression within the ventrolateral medulla can affect cardiovascular function during static exercise in stroked rats. Ally A and Maher TJ, Brain Res. 2008 Feb 27;1196:33-40. Epub 2007 Dec 27.
5. Study of insulin vascular sensitivity in aortic rings and endothelial cells from aged rats subjected to caloric restriction: Role of perivascular adipose tissue. Amor S, etal., Exp Gerontol. 2017 Oct 18. pii: S0531-5565(17)30591-0. doi: 10.1016/j.exger.2017.10.017.
6. Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats. An J, etal., Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1783-91. doi: 10.1152/ajpheart.00364.2009. Epub 2009 Aug 28.
7. Complementary inhibition of cerebral aneurysm formation by eNOS and nNOS. Aoki T, etal., Lab Invest. 2011 Apr;91(4):619-26. Epub 2011 Feb 14.
8. Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage. Arita R, etal., Diabetes. 2009 Jan;58(1):215-26. doi: 10.2337/db08-0762. Epub 2008 Oct 7.
9. Effect of cardamonin on hepatic ischemia reperfusion induced in rats: Role of nitric oxide. Atef Y, etal., Eur J Pharmacol. 2017 Nov 15;815:446-453. doi: 10.1016/j.ejphar.2017.09.037. Epub 2017 Sep 28.
10. Association of eNOS polymorphisms with primary angle-closure glaucoma. Awadalla MS, etal., Invest Ophthalmol Vis Sci. 2013 Mar 1;54(3):2108-14. doi: 10.1167/iovs.12-11391.
11. Endothelial nitric oxide synthase gene is associated with diabetic macular edema in type 2 diabetes. Awata T, etal., Diabetes Care. 2004 Sep;27(9):2184-90.
12. Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts. Ayub H, etal., Mol Vis. 2010 Jan 11;16:18-25.
13. Association analysis of genetic variations of eNOS and alpha2beta1 integrin genes with type 2 diabetic retinopathy. Azmy R, etal., Appl Clin Genet. 2012 Jul 24;5:55-65. doi: 10.2147/TACG.S31979. Print 2012.
14. Curcumin inhibits cardiac hypertrophy and improves cardiovascular function via enhanced Na+/Ca2+ exchanger expression after transverse abdominal aortic constriction in rats. Bai XJ, etal., Pharmacol Rep. 2017 Jul 15;70(1):60-68. doi: 10.1016/j.pharep.2017.07.014.
15. Post-Transcriptional Regulation of Hepatic DDAH1 with TNF Blockade Leads to Improved eNOS Function and Reduced Portal Pressure In Cirrhotic Rats. Balasubramanian V, etal., Sci Rep. 2017 Dec 20;7(1):17900. doi: 10.1038/s41598-017-18094-3.
16. Involvement of angiotensin II in the remodeling induced by a chronic decrease in blood flow in rat mesenteric resistance arteries. Baron-Menguy C, etal., Hypertens Res. 2010 Aug;33(8):857-66. doi: 10.1038/hr.2010.83. Epub 2010 Jun 10.
17. Endothelial nitric oxide synthase gene intron 4 (VNTR) polymorphism and vascular access graft thrombosis. Basaran O, etal., J Invest Surg. 2007 Jan-Feb;20(1):49-53.
18. Vascular endothelial function masks increased sympathetic vasopressor activity in rats with metabolic syndrome. Battault S, etal., Am J Physiol Heart Circ Physiol. 2017 Nov 10:ajpheart.00217.2017. doi: 10.1152/ajpheart.00217.2017.
19. Role of nitric oxide synthase gene intron 4 and exon 7 polymorphisms in obstructive sleep apnea syndrome. Bayazit YA, etal., Eur Arch Otorhinolaryngol. 2009 Mar;266(3):449-54. Epub 2008 Jul 24.
20. Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth. Bayraktutan U J Mol Cell Cardiol. 2004 Feb;36(2):277-86.
21. Selective dysregulation of nitric oxide synthase type 3 in cardiac myocytes but not coronary microvascular endothelial cells of spontaneously hypertensive rat. Bayraktutan U, etal., Cardiovasc Res. 1998 Jun;38(3):719-26.
22. Regulation by cAMP of post-translational processing and subcellular targeting of endothelial nitric-oxide synthase (type 3) in cardiac myocytes. Belhassen L, etal., J Biol Chem. 1997 Apr 25;272(17):11198-204.
23. Nitric oxide synthase (NOS3) and contractile responsiveness to adrenergic and cholinergic agonists in the heart. Regulation of NOS3 transcription in vitro and in vivo by cyclic adenosine monophosphate in rat cardiac myocytes. Belhassen L, etal., J Clin Invest. 1996 Apr 15;97(8):1908-15.
24. Association analyses of endothelial nitric oxide synthase gene polymorphisms in essential hypertension. Benjafield AV and Morris BJ, Am J Hypertens. 2000 Sep;13(9):994-8.
25. Cytoplasmic localization of endothelial constitutive nitric oxide synthase in endometrial carcinomas. Bentz BG, etal., Tumour Biol. 1997;18(5):290-300.
26. Role of nitric oxide synthases in elastase-induced emphysema. Boyer L, etal., Lab Invest. 2010 Oct 18.
27. Nitric oxide synthase expression and enzymatic activity in human brain tumors. Broholm H, etal., Clin Neuropathol. 2003 Nov-Dec;22(6):273-81.
28. Nitric oxide mediates the survival action of IGF-1 and insulin in pancreatic beta cells. Cahuana GM, etal., Cell Signal. 2008 Feb;20(2):301-10. Epub 2007 Oct 12.
29. Neoangiogenesis and the presence of progenitor cells in the venous limb of an arteriovenous fistula in the rat. Caplice NM, etal., Am J Physiol Renal Physiol. 2007 Aug;293(2):F470-5. Epub 2007 Mar 6.
30. Erectile dysfunction in young non-obese type II diabetic Goto-Kakizaki rats is associated with decreased eNOS phosphorylation at Ser1177. Carneiro FS, etal., J Sex Med. 2010 Nov;7(11):3620-34. doi: 10.1111/j.1743-6109.2010.02000.x. Epub 2010 Aug 30.
31. Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects. Casas JP, etal., Circulation. 2004 Mar 23;109(11):1359-65. Epub 2004 Mar 8.
32. Hypothermic machine perfusion with metformin-University of Wisconsin solution for ex vivo preservation of standard and marginal liver grafts in a rat model. Chai YC, etal., World J Gastroenterol. 2017 Oct 28;23(40):7221-7231. doi: 10.3748/wjg.v23.i40.7221.
33. Catechins Blunt the Effects of oxLDL and its Primary Metabolite Phosphatidylcholine Hydroperoxide on Endothelial Dysfunction Through Inhibition of Oxidative Stress and Restoration of eNOS in Rats. Chang HH, etal., Kidney Blood Press Res. 2017;42(5):919-932. doi: 10.1159/000485082. Epub 2017 Nov 22.
34. Oxidative stress is decreased in physically active sickle cell SAD mice. Charrin E, etal., Br J Haematol. 2015 Mar;168(5):747-56. doi: 10.1111/bjh.13207. Epub 2014 Nov 10.
35. Overexpression of human endothelial nitric oxide synthase in rat vascular smooth muscle cells and in balloon-injured carotid artery. Chen L, etal., Circ Res. 1998 May 4;82(8):862-70.
36. Inhibition of TGF-beta1 signaling by eNOS gene transfer improves ventricular remodeling after myocardial infarction through angiogenesis and reduction of apoptosis. Chen LL, etal., Cardiovasc Pathol. 2007 Jul-Aug;16(4):221-30. Epub 2007 May 11.
37. Exendin-4, a glucagon-like peptide-1 analogue accelerates healing of chronic gastric ulcer in diabetic rats. Chen YC, etal., PLoS One. 2017 Nov 2;12(11):e0187434. doi: 10.1371/journal.pone.0187434. eCollection 2017.
38. Hemin, a heme oxygenase-1 inducer, improves aortic endothelial dysfunction in insulin resistant rats. Chen YS, etal., Chin Med J (Engl). 2008 Feb 5;121(3):241-7.
39. Mechanical stretch induces endothelial nitric oxide synthase gene expression in neonatal rat cardiomyocytes. Cheng TH, etal., Clin Exp Pharmacol Physiol. 2009 May;36(5-6):559-66. doi: 10.1111/j.1440-1681.2008.05100.x. Epub 2008 Oct 28.
40. Cardioprotective effects of total flavonoids from Jinhe Yangxin prescription by activating the PI3K/Akt signaling pathway in myocardial ischemia injury. Cheng Y, etal., Biomed Pharmacother. 2017 Dec 20;98:308-317. doi: 10.1016/j.biopha.2017.12.052.
41. Change in endothelial nitric oxide synthase in the rat retina following transient ischemia. Cheon EW, etal., Neuroreport. 2003 Mar 3;14(3):329-33.
42. Association of a polymorphism of the ecNOS gene with myocardial infarction in a subgroup of Turkish MI patients. Cine N, etal., Clin Genet. 2002 Jan;61(1):66-70.
43. Exercise training induces eNOS coupling and restores relaxation in coronary arteries of heart failure rats. Couto GK, etal., Am J Physiol Heart Circ Physiol. 2018 Jan 5. doi: 10.1152/ajpheart.00624.2017.
44. Cardiac oxidative stress is elevated at the onset of dilated cardiomyopathy in streptozotocin-diabetic rats. Crespo MJ, etal., J Cardiovasc Pharmacol Ther. 2008 Mar;13(1):64-71.
45. Mechanism of eNOS gene transfer inhibition of vascular smooth muscle cell proliferation. D'Souza FM, etal., Am J Physiol Cell Physiol 2003 Jan;284(1):C191-9.
46. Association between Alzheimer's disease and the NOS3 gene. Dahiyat M, etal., Ann Neurol 1999 Oct;46(4):664-7.
47. Nitric oxide synthase 3-mediated neurodegeneration after intracerebral gene delivery. de la Monte SM, etal., J Neuropathol Exp Neurol. 2007 Apr;66(4):272-83.
48. Inhibition of vascular nitric oxide after rat chronic brain hypoperfusion: spatial memory and immunocytochemical changes. de la Torre JC and Aliev G, J Cereb Blood Flow Metab. 2005 Jun;25(6):663-72. doi: 10.1038/sj.jcbfm.9600057.
49. Endothelial nitric oxide synthase genotype and haplotype are not associated with diabetic retinopathy in diabetes type 2 patients. de Syllos RW, etal., Nitric Oxide. 2006 Dec;15(4):417-22. Epub 2006 Apr 3.
50. Vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (NOS3) polymorphisms are associated with high relapse risk in childhood acute lymphoblastic leukemia (ALL). Demacq C, etal., Clin Chim Acta. 2010 Sep 6;411(17-18):1335-40. doi: 10.1016/j.cca.2010.05.025. Epub 2010 May 25.
51. TNF-a antagonism with etanercept enhances penile NOS expression, cavernosal reactivity, and testosterone levels in aged rats. Demirtas Sahin T, etal., Can J Physiol Pharmacol. 2017 Dec 20:1-8. doi: 10.1139/cjpp-2017-0113.
52. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
53. Acupuncture protects the interstitial cells of Cajal by regulating miR-222 in a rat model of post-operative ileus. Deng JJ, etal., Acupunct Med. 2019 Apr;37(2):125-132. doi: 10.1177/0964528419829755. Epub 2019 Mar 11.
54. Polymorphism in intron 23 of the endothelial nitric oxide synthase gene (NOS3) is not associated with hypertension. Derebecka N, etal., Acta Biochim Pol. 2002;49(1):263-8.
55. Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-Schonlein purpura nephritis. Di B, etal., Mol Med Rep. 2012 Nov;6(5):1171-7. doi: 10.3892/mmr.2012.1032. Epub 2012 Aug 10.
56. Probiotics VSL#3 protect against development of visceral pain in murine model of irritable bowel syndrome. Distrutti E, etal., PLoS One. 2013 May 15;8(5):e63893. doi: 10.1371/journal.pone.0063893. Print 2013.
57. Constitutive nitric oxide synthase gene polymorphisms and house dust mite respiratory allergy in an Algerian patient group. Djidjik R, etal., Tissue Antigens. 2008 Feb;71(2):160-4. Epub 2007 Dec 13.
58. Hemopexin promotes angiogenesis via up-regulating HO-1 in rats after cerebral ischemia-reperfusion injury. Dong B, etal., BMC Anesthesiol. 2018 Jan 3;18(1):2. doi: 10.1186/s12871-017-0466-4.
59. High levels of exhaled nitric oxide (NO) and NO synthase III expression in lesional smooth muscle in lymphangioleiomyomatosis. Dweik RA, etal., Am J Respir Cell Mol Biol. 2001 Apr;24(4):414-8.
60. Nitric oxide synthase and NADPH-diaphorase after acute hypobaric hypoxia in the rat caudate putamen. Encinas JM, etal., Exp Neurol. 2004 Mar;186(1):33-45.
61. Selective resistance to vasoactive effects of insulin in muscle resistance arteries of obese Zucker (fa/fa) rats. Eringa EC, etal., Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1134-9. Epub 2007 Jul 10.
62. Endothelial nitric oxide synthase/soluble guanylate cyclase system in human nasal polyps. Escobar P, etal., Eur Arch Otorhinolaryngol. 2005 Jun;262(6):512-6. Epub 2004 Nov 18.
63. Endothelial nitric oxide synthase Glu298Asp, 4b/a, and T-786C polymorphisms in type 2 diabetic retinopathy. Ezzidi I, etal., Clin Endocrinol (Oxf). 2008 Apr;68(4):542-6. Epub 2007 Oct 31.
64. Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension. Fagan KA, etal., Respir Res. 2001;2(5):306-13. Epub 2001 Sep 4.
65. Neuroprotective effect of total flavonoids from Ilex pubescens against focal cerebral ischemia/reperfusion injury in rats. Fang X, etal., Mol Med Rep. 2017 Nov;16(5):7439-7449. doi: 10.3892/mmr.2017.7540. Epub 2017 Sep 20.
66. Xanthine Oxidase Activation Modulates the Endothelial (Vascular) Dysfunction Related to HgCl2 Exposure Plus Myocardial Infarction in Rats. Faria TO, etal., Cardiovasc Toxicol. 2017 Oct 4. doi: 10.1007/s12012-017-9427-x.
67. Nitric oxide synthase 3-dependent vascular remodeling and circulatory dysfunction in cirrhosis. Fernandez-Varo G, etal., Am J Pathol. 2003 Jun;162(6):1985-93.
68. Tetrahydrobiopterin (BH4 ): Targeting endothelial nitric oxide synthase as a potential therapy for pulmonary hypertension. Francis BN, etal., Cardiovasc Ther. 2018 Feb;36(1). doi: 10.1111/1755-5922.12312. Epub 2017 Dec 3.
69. Lack of association between an ecNOS gene polymorphism and diabetic nephropathy in type 2 diabetic patients with proliferative diabetic retinopathy. Fujita H, etal., Horm Metab Res. 2000 Feb;32(2):80-3.
70. A young girl with vasospastic angina associated with mutation in endothelial nitric oxide synthase gene--a case report. Fukuda N, etal., Angiology. 2003 Mar-Apr;54(2):233-7.
71. Molecular mechanism of limbs' postischemic revascularization improved by perindopril in diabetic rats. Gao L and Yu DM, Chin Med J (Engl). 2008 Nov 5;121(21):2129-33.
72. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
73. Vascular invasion in human breast cancer is correlated to T-->786C polymorphism of NOS3 gene. Ghilardi G, etal., Nitric Oxide. 2003 Sep;9(2):118-22.
74. Evidence for a functional nitric oxide synthase system in brown adipocyte nucleus. Giordano A, etal., FEBS Lett. 2002 Mar 13;514(2-3):135-40.
75. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
76. Endothelial nitric oxide synthase expression in leiomyoma and parental myometrium. Gokdeniz R, etal., Gynecol Obstet Invest. 2000;49(2):132-6.
77. Effects of early overnutrition on the renal response to Ang II and expression of RAAS components in rat renal tissue. Granado M, etal., Nutr Metab Cardiovasc Dis. 2017 Oct;27(10):930-937. doi: 10.1016/j.numecd.2017.06.019. Epub 2017 Jul 8.
78. Arginase upregulation and eNOS uncoupling contribute to impaired endothelium-dependent vasodilation in a rat model of intrauterine growth restriction. Grandvuillemin I, etal., Am J Physiol Regul Integr Comp Physiol. 2018 Sep 1;315(3):R509-R520. doi: 10.1152/ajpregu.00354.2017. Epub 2018 May 9.
79. Endothelial nitric oxide synthase variants in cystic fibrosis lung disease. Grasemann H, etal., Am J Respir Crit Care Med. 2003 Feb 1;167(3):390-4. Epub 2002 Aug 15.
80. Neuroprotective effect of citicoline on retinal cell damage induced by kainic acid in rats. Han YS, etal., Korean J Ophthalmol. 2005 Sep;19(3):219-26.
81. Roles of constitutive nitric oxide synthase in postischemic rat retina. Hangai M, etal., Invest Ophthalmol Vis Sci. 1999 Feb;40(2):450-8.
82. Association of nitric oxide synthase 3 (NOS3) 894 G>T polymorphism with prognostic outcomes of anthracycline in Chinese patients with acute myeloid leukaemia. He H, etal., Clin Exp Pharmacol Physiol. 2014 Jun;41(6):400-7. doi: 10.1111/1440-1681.12235.
83. Polymorphisms of the endothelial nitric oxide synthase gene in ovarian cancer. Hefler LA, etal., Gynecol Oncol. 2002 Aug;86(2):134-7.
84. TGFbeta receptor activation enhances cardiac apoptosis via SMAD activation and concomitant NO release. Heger J, etal., J Cell Physiol. 2010 Dec 29.
85. TGFbeta receptor activation enhances cardiac apoptosis via SMAD activation and concomitant NO release. Heger J, etal., J Cell Physiol. 2011 Oct;226(10):2683-90. doi: 10.1002/jcp.22619.
86. Abnormal regulation of aortic NOS2 and NOS3 activity and expression from portal vein-stenosed rats after lipopolysaccharide administration. Heller J, etal., Hepatology. 1999 Sep;30(3):698-704.
87. A high-salt diet dissociates NO synthase-3 expression and NO production by the thick ascending limb. Herrera M, etal., Hypertension. 2006 Jan;47(1):95-101. Epub 2005 Dec 12.
88. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Hildebrandt MA, etal., PLoS One. 2010 Aug 25;5(8):e12402.
89. Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease. Hoehn T, etal., Respir Res. 2009 Nov 13;10:110.
90. Haplotype analysis of the endothelial nitric oxide synthase gene in asthma. Holla LI, etal., Hum Immunol. 2008 Apr-May;69(4-5):306-13. Epub 2008 Apr 15.
91. Association study of promoter polymorphisms within the NOS3 gene and allergic diseases. Holla LI, etal., Int Arch Allergy Immunol. 2006;141(2):103-9. Epub 2006 Jul 12.
92. The relationship between polymorphisms in the endothelial cell nitric oxide synthase gene and the platelet GPIIIa gene with myocardial infarction and venous thromboembolism in African Americans. Hooper WC, etal., Chest. 1999 Oct;116(4):880-6.
93. Maternal Exposure to Bisphenol A Combined with High-Fat Diet-Induced Programmed Hypertension in Adult Male Rat Offspring: Effects of Resveratrol. Hsu CN, etal., Int J Mol Sci. 2019 Sep 6;20(18):4382. doi: 10.3390/ijms20184382.
94. Role of hepatic nitric oxide synthases in rats with thioacetamide-induced acute liver failure and encephalopathy. Huang HC, etal., J Chin Med Assoc. 2007 Jan;70(1):16-23.
95. Developmental regulation of nitric oxide synthase expression in rat skeletal bone. Hukkanen MV, etal., J Bone Miner Res. 1999 Jun;14(6):868-77.
96. Dynamin activates NO production in rat renal inner medullary collecting ducts via protein-protein interaction with NOS1. Hyndman KA, etal., Am J Physiol Renal Physiol. 2011 Apr 13.
97. Heat shock regulates the respiration of cardiac H9c2 cells through upregulation of nitric oxide synthase. Ilangovan G, etal., Am J Physiol Cell Physiol. 2004 Nov;287(5):C1472-81.
98. Association of the Glu298Asp polymorphism in the endothelial nitric oxide synthase gene with essential hypertension resistant to conventional therapy. Jachymova M, etal., Biochem Biophys Res Commun. 2001 Jun 8;284(2):426-30.
99. Expression of nitric oxide synthase, aquaporin 1 and aquaporin 5 in rat after bleomycin inhalation. Jang AS, etal., Intensive Care Med. 2004 Mar;30(3):489-95. Epub 2004 Feb 6.
100. Pregnancy alters nitric oxide synthase and natriuretic peptide systems in the rat left ventricle. Jankowski M, etal., J Endocrinol. 2005 Jan;184(1):209-17.
101. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea. Jelic S, etal., Circulation. 2008 Apr 29;117(17):2270-8. Epub 2008 Apr 14.
102. Vascular inflammation in obesity and sleep apnea. Jelic S, etal., Circulation. 2010 Mar 2;121(8):1014-21. Epub 2010 Feb 16.
103. [Preventive effect of endothelial nitric oxide synthase gene transfer on chronic hypoxic pulmonary hypertension in rats]. Jin Q, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009 Apr;21(4):222-5.
104. Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cells. Joshi MS, etal., Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):9982-7. Epub 2007 May 29.
105. Up-regulated eNOS protects blood-retinal barrier in the L-arginine treated ischemic rat retina. Ju WK, etal., Neuroreport. 2001 Aug 8;12(11):2405-9.
106. Esculetin ameliorates vascular perturbation by intervening in the occupancy of H2BK120Ub at At1, At2, Tgfß1 and Mcp1 promoter gene in thoracic aorta of IR and T2D rats. Kadakol A, etal., Biomed Pharmacother. 2017 Nov;95:1461-1468. doi: 10.1016/j.biopha.2017.09.067. Epub 2017 Sep 21.
107. Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with hypertension, alcohol intake, and cigarette smoking. Kang JH, etal., Arch Ophthalmol. 2011 Jun;129(6):773-80. doi: 10.1001/archophthalmol.2011.118.
108. Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use. Kang JH, etal., Invest Ophthalmol Vis Sci. 2010 Feb;51(2):971-9. doi: 10.1167/iovs.09-4266. Epub 2009 Oct 8.
109. Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension. Kanki-Horimoto S, etal., Circulation. 2006 Jul 4;114(1 Suppl):I181-5.
110. Lack of evidence for association between endothelial nitric oxide synthase gene polymorphism (glu298asp) with Behcet's disease in the Turkish population. Kara N, etal., Arch Dermatol Res. 2006 Apr;297(10):468-71. Epub 2006 Feb 7.
111. Polymorphisms in the endothelial nitric oxide synthase gene are associated with Behcet's disease. Karasneh JA, etal., Rheumatology (Oxford). 2005 May;44(5):614-7. Epub 2005 Feb 10.
112. Lack of evidence for association between the endothelial nitric oxide synthase gene and hypertension. Kato N, etal., Hypertension. 1999 Apr;33(4):933-6.
113. Constitutive endothelial nitric oxide synthase gene expression is regulated during lung development. Kawai N, etal., Am J Physiol 1995 Apr;268(4 Pt 1):L589-95.
114. Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use. Kendirci M, etal., Eur Urol. 2007 Aug;52(2):555-63. Epub 2007 Mar 20.
115. Hyperhomocysteinemia, endothelial nitric oxide synthase polymorphism, and risk of coronary artery disease. Kerkeni M, etal., Clin Chem. 2006 Jan;52(1):53-8. Epub 2005 Nov 10.
116. Oxygen cycling in conjunction with stem cell transplantation induces NOS3 expression leading to attenuation of fibrosis and improved cardiac function. Khan M, etal., Cardiovasc Res. 2012 Jan 1;93(1):89-99. doi: 10.1093/cvr/cvr277. Epub 2011 Oct 19.
117. Endothelial nitric oxide synthase gene polymorphisms in Behcet's disease and rheumatic diseases with vasculitis. Kim JU, etal., Ann Rheum Dis. 2003 Nov;62(11):1083-7.
118. Phospho-eNOS Ser-1176 is associated with the nucleoli and the Golgi complex in C6 rat glioma cells. Klinz FJ, etal., Neurosci Lett. 2007 Jun 29;421(3):224-8. Epub 2007 May 26.
119. Immunolocalization of inducible and constitutive nitric oxide synthases in human bladder cancer. Klotz T, etal., Urology. 1999 Sep;54(3):416-9.
120. The effect of overexpression of endothelial nitric oxide synthase on eosinophilic lung inflammation in a murine model. Kobayashi K, etal., Int Immunopharmacol. 2006 Jul;6(7):1040-52. Epub 2005 Dec 1.
121. REDOX REGULATION OF ISCHEMIC PRECONDITIONING IS MEDIATED BY THE DIFFERENTIAL ACTIVATION OF CAVEOLINS AND THEIR ASSOCIATION WITH eNOS AND GLUT-4. Koneru S, etal., Am J Physiol Heart Circ Physiol. 2007 Feb 2;.
122. Polymorphisms of ABCC5 and NOS3 genes influence doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia. Krajinovic M, etal., Pharmacogenomics J. 2015 Sep 8. doi: 10.1038/tpj.2015.63.
123. Caveolin-3 and eNOS colocalize and interact in ciliated airway epithelial cells in the rat. Krasteva G, etal., Int J Biochem Cell Biol. 2007;39(3):615-25. Epub 2006 Oct 29.
124. Increased expression of endothelial nitric oxide synthase and caveolin-1 in the aorta of rats with isoproterenol-induced cardiac hypertrophy. Krenek P, etal., Can J Physiol Pharmacol. 2006 Dec;84(12):1245-50.
125. Genetic predictors of long-term toxicities after radiation therapy for breast cancer. Kuptsova N, etal., Int J Cancer. 2008 Mar 15;122(6):1333-9.
126. Administration of a low dose of sildenafil for 1 week decreases intrahepatic resistance in rats with biliary cirrhosis: the role of NO bioavailability. Lee KC, etal., Clin Sci (Lond). 2010 Apr 7;119(1):45-55. doi: 10.1042/CS20090601.
127. Genetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvement. Lee KM, etal., Breast Cancer Res Treat. 2007 Dec;106(3):433-8. Epub 2007 Jan 30.
128. Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo study. Lee NP, etal., Biol Reprod. 2005 Sep;73(3):458-71. Epub 2005 Apr 27.
129. Associations between eNOS polymorphisms and susceptibility to Behcet's disease: a meta-analysis. Lee YH and Song GG, J Eur Acad Dermatol Venereol. 2012 Oct;26(10):1266-71. doi: 10.1111/j.1468-3083.2011.04280.x. Epub 2011 Sep 29.
130. Changes of pulmonary pathology and gene expressions after simvastatin treatment in the monocrotaline-induced pulmonary hypertension rat model. Lee YH, etal., Korean Circ J. 2011 Sep;41(9):518-27. doi: 10.4070/kcj.2011.41.9.518. Epub 2011 Sep 29.
131. Orientin Reduces Myocardial Infarction Size via eNOS/NO Signaling and Thus Mitigates Adverse Cardiac Remodeling. Li F, etal., Front Pharmacol. 2017 Dec 21;8:926. doi: 10.3389/fphar.2017.00926. eCollection 2017.
132. FXR-mediated regulation of eNOS expression in vascular endothelial cells. Li J, etal., Cardiovasc Res. 2008 Jan;77(1):169-77. Epub 2007 Sep 19.
133. Genistein prevents myocardial hypertrophy in 2-kidney 1-clip renal hypertensive rats by restoring eNOS pathway. Li J, etal., Pharmacology. 2010;86(4):240-8. Epub 2010 Oct 13.
134. Effects of rat urotensin II on coronary flow and myocardial eNOS protein expression in isolated rat heart. Li L, etal., Acta Pharmacol Sin. 2004 Nov;25(11):1444-9.
135. Diabetic eNOS-knockout mice develop accelerated retinopathy. Li Q, etal., Invest Ophthalmol Vis Sci. 2010 Oct;51(10):5240-6. doi: 10.1167/iovs.09-5147. Epub 2010 Apr 30.
136. Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity. Li R, etal., Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1703-8. Epub 2007 Sep 25.
137. Endothelial nitric oxide synthase is expressed in amacrine cells of developing human retinas. Li S, etal., Invest Ophthalmol Vis Sci. 2006 May;47(5):2141-9.
138. Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease. Li T, etal., Biochem Biophys Res Commun. 2018 Jan 8;495(2):2071-2077. doi: 10.1016/j.bbrc.2017.12.069. Epub 2017 Dec 13.
139. Sulodexide recovers endothelial function through reconstructing glycocalyx in the balloon-injury rat carotid artery model. Li T, etal., Oncotarget. 2017 Aug 24;8(53):91350-91361. doi: 10.18632/oncotarget.20518. eCollection 2017 Oct 31.
140. Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion. Li Y, etal., Life Sci. 2011 Jan 3;88(1-2):104-9. Epub 2010 Nov 4.
141. Association of genetic polymorphisms of eNOS with glaucoma. Liao Q, etal., Mol Vis. 2011 Jan 13;17:153-8.
142. Critical contribution of Na+-Ca2+ exchanger to the Ca2+-mediated vasodilation activated in endothelial cells of resistance arteries. Lillo MA, etal., FASEB J. 2017 Dec 7. pii: fj.201700365RR. doi: 10.1096/fj.201700365RR.
143. Gender Differences in the Acute Kidney Injury to Chronic Kidney Disease Transition. Lima-Posada I, etal., Sci Rep. 2017 Sep 25;7(1):12270. doi: 10.1038/s41598-017-09630-2.
144. Oral nicotine aggravates endothelial dysfunction and vascular inflammation in diet-induced obese rats: Role of macrophage TNFa. Liu C, etal., PLoS One. 2017 Dec 13;12(12):e0188439. doi: 10.1371/journal.pone.0188439. eCollection 2017.
145. Expression of VEGF, iNOS, and eNOS is increased in cochlea of diabetic rat. Liu F, etal., Acta Otolaryngol. 2008 Apr 14:1-9.
146. Sleeping Beauty-mediated eNOS gene therapy attenuates monocrotaline-induced pulmonary hypertension in rats. Liu L, etal., FASEB J. 2006 Dec;20(14):2594-6. Epub 2006 Oct 25.
147. [Effect of Point-moxibustion and Electroacupuncture on the Expression of Endothelial Nitric Oxide Synthase mRNA and Angiotensin 2 mRNA in Gastric Antrum in Diabetic Gastroparesis Rats]. Liu L, etal., Zhen Ci Yan Jiu. 2017 Jun 25;42(3):240-5.
148. Hemorrhagic shock-induced vascular hyporeactivity in the rat: relationship to gene expression of nitric oxide synthase, endothelin-1, and select cytokines in corresponding organs. Liu LM and Dubick MA, J Surg Res. 2005 May 15;125(2):128-36.
149. Functional status of microvascular vasomotion is impaired in spontaneously hypertensive rat. Liu M, etal., Sci Rep. 2017 Dec 6;7(1):17080. doi: 10.1038/s41598-017-17013-w.
150. Nitric oxide synthase and arginase expression changes in the rat perirhinal and entorhinal cortices following unilateral vestibular damage: a link to deficits in object recognition? Liu P, etal., J Vestib Res. 2004;14(6):411-7.
151. A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Liu S, etal., Nat Med. 2005 Sep;11(9):952-8. Epub 2005 Sep 4.
152. Evidence for association of endothelial nitric oxide synthase gene in subjects with glaucoma and a history of migraine. Logan JF, etal., Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3221-6.
153. Decreased renal expression of nitric oxide synthase isoforms in adrenocorticotropin-induced and corticosterone-induced hypertension. Lou YK, etal., Hypertension. 2001 Apr;37(4):1164-70.
154. Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and acute pulmonary hypertension post cardiopulmonary bypass in children with congenital cardiac diseases. Loukanov T, etal., Cardiol Young. 2010 Dec 10:1-9.
155. Promoter polymorphism (-786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non-Hispanic white women age younger than 55 years. Lu J, etal., Cancer. 2006 Nov 1;107(9):2245-53.
156. Therapeutic ultrasound plus pulsed electromagnetic field improves recovery from peripheral arterial disease in hypertension. Lu ZY, etal., Am J Transl Res. 2017 Sep 15;9(9):4184-4194. eCollection 2017.
157. Treatment with low-dose atorvastatin, losartan, and their combination increases expression of vasoactive-related genes in rat aortas. Lunder M, etal., J Cardiovasc Pharmacol Ther. 2013 Mar;18(2):177-83. doi: 10.1177/1074248412463966. Epub 2012 Oct 22.
158. The role of sildenafil in the development of transplant arteriosclerosis in rat aortic grafts. Luo S, etal., Am J Transl Res. 2017 Nov 15;9(11):4914-4924. eCollection 2017.
159. Aberrant expression of NOS isoforms in Alzheimer's disease is structurally related to nitrotyrosine formation. Lüth HJ, etal., Brain Res. 2002 Oct 25;953(1-2):135-43.
160. Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population. Magalhaes da Silva T, etal., Gene. 2012 Jul 10;502(2):142-6. doi: 10.1016/j.gene.2012.04.047. Epub 2012 Apr 24.
161. Discrepant effects of inducible nitric oxide synthase modulation on systemic and splanchnic endothelial nitric oxide synthase activity and expression in cirrhotic rats. Malyshev E, etal., J Gastroenterol Hepatol. 2007 Dec;22(12):2195-201.
162. The endothelial nitric oxide synthase Glu-298-Asp polymorphism and its mRNA expression in the peripheral blood of patients with prostate cancer and benign prostatic hyperplasia. Marangoni K, etal., Cancer Detect Prev. 2006;30(1):7-13. Epub 2006 Feb 2.
163. Role of NOS3 DNA variants in externalizing behavioral problems observed in childhood leukemia survivors. Marcoux S, etal., J Pediatr Hematol Oncol. 2013 May;35(4):e157-62. doi: 10.1097/MPH.0b013e31828e518d.
164. Abnormal cannabidiol confers cardioprotection in diabetic rats independent of glycemic control. Matouk AI, etal., Eur J Pharmacol. 2018 Feb 5;820:256-264. doi: 10.1016/j.ejphar.2017.12.039. Epub 2017 Dec 20.
165. Angiotensin II Type-1 Receptor Blocker Preserves Tolerance to Ischemia/Reperfusion Injury in Dahl Salt-sensitive Rat Heart. Matsuhisa S, etal., Am J Physiol Heart Circ Physiol. 2008 Apr 4;.
166. Age-related alterations in reactivity of cerebral arterioles: role of oxidative stress. Mayhan WG, etal., Microcirculation. 2008 Apr-May;15(3):225-36.
167. Rate, affinity and calcium dependence of nitric oxide synthase isoform binding to the primary physiological regulator calmodulin. McMurry JL, etal., FEBS J. 2011 Dec;278(24):4943-54. doi: 10.1111/j.1742-4658.2011.08395.x. Epub 2011 Nov 11.
168. Endothelial nitric oxide synthase gene polymorphisms and the shedding of circulating tumour cells in the blood of prostate cancer patients. Medeiros R, etal., Cancer Lett. 2003 Jan 10;189(1):85-90.
169. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
170. A polymorphism (G894T) in eNOS increases the risk of coronary atherosclerosis rather than intracranial atherosclerosis in Koreans. Min BW, etal., Acta Neurol Belg. 2010 Sep;110(3):255-62.
171. Effect of AOB, a fermented-grain food supplement, on oxidative stress in type 2 diabetic rats. Minamiyama Y, etal., Biofactors. 2007;30(2):91-104.
172. Uncoupled endothelial nitric oxide synthase and oxidative stress in a rat model of pregnancy-induced hypertension. Mitchell BM, etal., Am J Hypertens. 2007 Dec;20(12):1297-304.
173. Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Miyamoto Y, etal., Hypertension. 1998 Jul;32(1):3-8.
174. Renal intramedullary infusion of L-arginine prevents reduction of medullary blood flow and hypertension in Dahl salt-sensitive rats. Miyata N and Cowley AW Jr, Hypertension 1999 Jan;33(1 Pt 2):446-50.
175. Sepsis is associated with an upregulation of functional beta3 adrenoceptors in the myocardium. Moniotte S, etal., Eur J Heart Fail. 2007 Dec;9(12):1163-71. Epub 2007 Nov 19.
176. New developments in anthracycline-induced cardiotoxicity. Mordente A, etal., Curr Med Chem. 2009;16(13):1656-72.
177. Regulation of endothelial nitric oxide synthase by agmatine after transient global cerebral ischemia in rat brain. Mun CH, etal., Anat Cell Biol. 2010 Sep;43(3):230-40. Epub 2010 Sep 30.
178. Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension. Murata T, etal., J Biol Chem 2002 Nov 15;277(46):44085-92. Epub 2002 Aug 15.
179. Leupeptin preserves cardiac nitric oxide synthase 3 during reperfusion following long-term cardioplegia. Muscari C, etal., J Surg Res. 2010 Nov;164(1):e27-35. Epub 2010 Jun 12.
180. Post-translational regulation of endothelial nitric oxide synthase (eNOS) by estrogens in the rat vagina. Musicki B, etal., J Sex Med. 2010 May;7(5):1768-77. Epub 2010 Mar 11.
181. eNOS 894T allele and coronary blood flow at rest and during adenosine-induced hyperemia. Naber CK, etal., Am J Physiol Heart Circ Physiol. 2001 Nov;281(5):H1908-12.
182. Association of ecNOS gene polymorphisms with end stage renal diseases. Nagase S, etal., Mol Cell Biochem. 2003 Feb;244(1-2):113-8.
183. Rosuvastatin reduces rat intestinal ischemia-reperfusion injury associated with the preservation of endothelial nitric oxide synthase protein. Naito Y, etal., World J Gastroenterol. 2006 Apr 7;12(13):2024-30.
184. Association analysis of CA repeat polymorphism of the endothelial nitric oxide synthase gene with essential hypertension in Japanese. Nakayama T, etal., Clin Genet. 1997 Jan;51(1):26-30.
185. Topiramate as a neuroprotective agent in a rat model of spinal cord injury. Narin F, etal., Neural Regen Res. 2017 Dec;12(12):2071-2076. doi: 10.4103/1673-5374.221164.
186. Nitric oxide synthase immunolocalization and expression in the rat hippocampus after sub-acute lead acetate exposure in rats. Nava-Ruiz C, etal., Exp Toxicol Pathol. 2010 May;62(3):311-6. Epub 2009 Jun 12.
187. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
188. Association of the nitric oxide synthase gene polymorphism with an increased risk for progression to diabetic nephropathy in type 2 diabetes. Neugebauer S, etal., Diabetes. 2000 Mar;49(3):500-3.
189. Endothelial nitric oxide synthase gene polymorphism is associated with sickle cell disease patients in India. Nishank SS, etal., J Hum Genet. 2013 Dec;58(12):775-9. doi: 10.1038/jhg.2013.99. Epub 2013 Oct 3.
190. Decrease in renal medullary endothelial nitric oxide synthase of fructose-fed, salt-sensitive hypertensive rats. Nishimoto Y, etal., Hypertension 2002 Aug;40(2):190-4.
191. Pulmonary endothelial nitric oxide synthase gene expression is decreased in a rat model of congenital diaphragmatic hernia. North AJ, etal., Am J Respir Cell Mol Biol. 1995 Dec;13(6):676-82.
192. Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. North ML, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L911-20. Epub 2009 Mar 13.
193. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
194. Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes. Ostrom RS, etal., J Biol Chem. 2004 May 7;279(19):19846-53. Epub 2004 Mar 8.
195. L-arginine restores endothelial nitric oxide synthase-coupled activity and attenuates monocrotaline-induced pulmonary artery hypertension in rats. Ou ZJ, etal., Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1131-9. Epub 2010 Mar 9.
196. Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice. Ozaki M, etal., J Clin Invest. 2002 Aug;110(3):331-40.
197. The effect of regular exercise on penile nitric oxide synthase expression in rats. Ozbek E, etal., Int J Androl. 2010 Aug 1;33(4):623-8. Epub 2009 Sep 26.
198. Carvacrol attenuates histopathogic and functional impairments induced by bilateral renal ischemia/reperfusion in rats. Ozturk H, etal., Biomed Pharmacother. 2017 Dec 29;98:656-661. doi: 10.1016/j.biopha.2017.12.060.
199. Modifications of expression of genes and proteins involved in DNA repair and nitric oxide metabolism by carbatonides [disodium-2,6-dimethyl-1,4-dihydropyridine- 3,5-bis(carbonyloxyacetate) derivatives] in intact and diabetic rats. Ošina K, etal., Arh Hig Rada Toksikol. 2017 Sep 26;68(3):212-227. doi: 10.1515/aiht-2017-68-2945.
200. Safranal prevents rotenone-induced oxidative stress and apoptosis in an in vitro model of Parkinson's disease through regulating Keap1/Nrf2 signaling pathway. Pan PK, etal., Cell Mol Biol (Noisy-le-grand). 2016 Dec 30;62(14):11-17. doi: 10.14715/cmb/ 2016.62.14.2.
201. Microvascular endothelial dysfunction and its mechanism in a rat model of subarachnoid hemorrhage. Park KW, etal., Anesth Analg. 2001 Apr;92(4):990-6.
202. Acute sleep deprivation preconditions the heart against ischemia/ reperfusion injury: the role of central GABA-A receptors. Parsa H, etal., Iran J Basic Med Sci. 2017 Nov;20(11):1232-1241. doi: 10.22038/IJBMS.2017.9539.
203. Role of aortic nitric oxide synthase 3 (eNOS) in the systemic vasodilation of portal hypertension. Pateron D, etal., Gastroenterology. 2000 Jul;119(1):196-200.
204. Grape pomace reduced reperfusion arrhythmias in rats with a high-fat-fructose diet. Perdicaro DJ, etal., Food Funct. 2017 Oct 18;8(10):3501-3509. doi: 10.1039/c7fo01062a.
205. eNOS involved in colitis-induced mucosal blood flow increase. Petersson J, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Dec;293(6):G1281-7. Epub 2007 Oct 18.
206. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
207. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
208. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
209. Cupuaçu extract reduces nitrosative stress and modulates inflammatory mediators in the kidneys of experimental diabetes. Punaro GR, etal., Clin Nutr. 2017 Dec 26. pii: S0261-5614(17)31436-X. doi: 10.1016/j.clnu.2017.12.016.
210. Genetic polymorphism of NOS3 with susceptibility to deep vein thrombosis after orthopedic surgery: a case-control study in Chinese Han population. Qin J, etal., PLoS One. 2013 Jul 26;8(7):e70033. doi: 10.1371/journal.pone.0070033. Print 2013.
211. Tumor necrosis factor alpha decreases nitric oxide synthase type 3 expression primarily via Rho/Rho kinase in the thick ascending limb. Ramseyer VD, etal., Hypertension. 2012 Jun;59(6):1145-50. doi: 10.1161/HYPERTENSIONAHA.111.189761. Epub 2012 May 7.
212. Caveolin-1 and -3 dissociations from caveolae to cytosol in the heart during aging and after myocardial infarction in rat. Ratajczak P, etal., Cardiovasc Res. 2003 Feb;57(2):358-69.
213. Early intervention with Didang decoction delays macrovascular lesions in diabetic rats through regulating AMP-activated protein kinase signaling pathway. Ren DD, etal., Chin J Nat Med. 2017 Nov;15(11):847-854. doi: 10.1016/S1875-5364(18)30018-9.
214. Maintained upregulation of pulmonary eNOS gene and protein expression during recovery from chronic hypoxia. Resta TC, etal., Am J Physiol. 1999 Feb;276(2 Pt 2):H699-708.
215. GOA pipeline RGD automated data pipeline
216. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
217. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
218. Enhancement of endothelial nitric oxide synthase production reverses vascular dysfunction and inflammation in the hindlimbs of a rat model of diabetes. Riad A, etal., Diabetologia. 2008 Dec;51(12):2325-32. Epub 2008 Sep 30.
219. Dietary sodium intake regulates angiotensin II type 1, mineralocorticoid receptor, and associated signaling proteins in heart. Ricchiuti V, etal., J Endocrinol. 2011 Oct;211(1):47-54. doi: 10.1530/JOE-10-0458. Epub 2011 Jul 11.
220. Polymorphisms of the endothelial nitric oxide synthase gene in women with vulvar cancer. Riener EK, etal., Gynecol Oncol. 2004 Jun;93(3):686-90.
221. Lack of association between NOS3 Glu298Asp and breast cancer risk: a case-control study. Royo JL, etal., Breast Cancer Res Treat. 2006 Dec;100(3):331-3.
222. Endothelial NOS-derived nitric oxide prevents injury resulting from reoxygenation in the hypoxic lung. Rus A, etal., Free Radic Res. 2010 Sep;44(9):1027-35.
223. Endothelial nitric oxide synthase gene T-786C and 27-bp repeat gene polymorphisms in retinopathy of prematurity. Rusai K, etal., Mol Vis. 2008 Feb 5;14:286-90.
224. Ingested capsaicinoids can prevent low-fat-high-carbohydrate diet and high-fat diet-induced obesity by regulating the NADPH oxidase and Nrf2 pathways. Sahin K, etal., J Inflamm Res. 2017 Nov 13;10:161-168. doi: 10.2147/JIR.S149087. eCollection 2017.
225. Endothelial nitric oxide synthase gene polymorphisms in non-arteritic anterior ischemic optic neuropathy. Sakai T, etal., Graefes Arch Clin Exp Ophthalmol. 2007 Feb;245(2):288-92.
226. Endothelial nitric oxide synthase gene polymorphisms in Behcet's disease. Salvarani C, etal., J Rheumatol. 2002 Mar;29(3):535-40.
227. Relationship of endothelial nitric oxide synthase (eNOS) gene polymorphisms with diabetic retinopathy in Caucasians with type 2 diabetes. Santos KG, etal., Ophthalmic Genet. 2012 Mar;33(1):23-7. doi: 10.3109/13816810.2011.620057. Epub 2011 Oct 21.
228. Role of Nitric Oxide Pathway in Development and Progression of Chronic Kidney Disease in Rats Sensitive and Resistant to its Occurrence in an Experimental Model of 5/6 Nephrectomy. Saracyn M, etal., Med Sci Monit. 2017 Oct 11;23:4865-4873.
229. Protective effect of 17beta-estradiol on ischemic acute renal failure through the PI3K/Akt/eNOS pathway. Satake A, etal., Kidney Int. 2008 Feb;73(3):308-17. Epub 2007 Nov 14.
230. Association of polymorphisms of angiogenesis genes with breast cancer. Schneider BP, etal., Breast Cancer Res Treat. 2007 Sep 20;.
231. Nephroprotection through the Akt/eNOS pathway by centrally administered erythropoietin in a rat model of fixed-volume hemorrhage. Seifi B, etal., Life Sci. 2017 Nov 6. pii: S0024-3205(17)30580-5. doi: 10.1016/j.lfs.2017.11.003.
232. Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion. Seujange Y, etal., Am J Nephrol. 2008;28(4):692-700. doi: 10.1159/000126927. Epub 2008 Apr 11.
233. Regulation of hepatic eNOS by caveolin and calmodulin after bile duct ligation in rats. Shah V, etal., Am J Physiol Gastrointest Liver Physiol. 2001 Jun;280(6):G1209-16.
234. Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat. Shah V, etal., Gastroenterology. 1999 Nov;117(5):1222-8.
235. Association of T-786C eNOS gene polymorphism with increased susceptibility to acute chest syndrome in females with sickle cell disease. Sharan K, etal., Br J Haematol. 2004 Jan;124(2):240-3.
236. Nocturnal oxygen therapy prevents progress of congestive heart failure with central sleep apnea. Shigemitsu M, etal., Int J Cardiol. 2007 Feb 14;115(3):354-60. Epub 2006 Jun 23.
237. Intrauterine growth restriction and shallower implantation site in rats with maternal hyperinsulinemia are associated with altered NOS expression. Skarzinski G, etal., Placenta. 2009 Oct;30(10):898-906. Epub 2009 Aug 25.
238. Hydrogen Sulfide Releasing 2-Mercaptoacrylic Acid-Based Derivative Possesses Cytoprotective Activity in a Small Intestine of Rats with Medication-Induced Enteropathy. Sklyarova Y, etal., Sci Pharm. 2017 Oct 24;85(4). pii: E35. doi: 10.3390/scipharm85040035.
239. Renal nitric oxide production in rat pregnancy: role of constitutive nitric oxide synthases. Smith CA, etal., Am J Physiol Renal Physiol. 2010 Oct;299(4):F830-6. Epub 2010 Jul 14.
240. Human endothelial nitric oxide synthase gene delivery promotes angiogenesis in a rat model of hindlimb ischemia. Smith RS Jr, etal., Arterioscler Thromb Vasc Biol. 2002 Aug 1;22(8):1279-85.
241. Differential effects of chronic hypoxia and intermittent hypocapnic and eucapnic hypoxia on pulmonary vasoreactivity. Snow JB, etal., J Appl Physiol. 2008 Jan;104(1):110-8. Epub 2007 Oct 18.
242. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego Sobstyl J, etal., Pol Merkuriusz Lek. 2002 Jul;13(73):10-3.
243. Expression of eNOS in the lungs of neonates with pulmonary hypertension. Sood BG, etal., Exp Mol Pathol. 2011 Feb;90(1):9-12. Epub 2010 Nov 24.
244. FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. Spiekerkoetter E, etal., J Clin Invest. 2013 Aug;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15.
245. Influence of salt on subcellular localization of nitric oxide synthase activity and expression in the renal inner medulla. Sullivan JC, etal., Clin Exp Pharmacol Physiol. 2008 Feb;35(2):120-5. Epub 2007 Sep 24.
246. Altered nitric oxide synthase 3 distribution in mesenteric arteries of hypertensive rats. Sullivan JC, etal., Hypertension. 2002 Feb;39(2 Pt 2):597-602.
247. [Gene polymorphism of the endothelial nitric oxide synthase enzyme and pulmonary hypertension in patient with chronic obstructive pulmonary disease]. Sun LR, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2008 May;31(5):335-40.
248. Bronchiolitis obliterans induced by intratracheal papaverine: a novel animal model. Svetlecic J, etal., Lung. 2004;182(2):119-34.
249. Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD. Synowiec E, etal., Front Biosci (Landmark Ed). 2013 Jan 1;18:80-90.
250. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
251. Subcellular distribution of nitric oxide synthase isoforms in the rat duodenum. Talapka P, etal., World J Gastroenterol. 2011 Feb 28;17(8):1026-9.
252. Orthodontic force stimulates eNOS and iNOS in rat osteocytes. Tan SD, etal., J Dent Res. 2009 Mar;88(3):255-60.
253. Endothelial nitric oxide synthase gene intron 4 variable number tandem repeat polymorphism in beta-thalassemia major: relation to cardiovascular complications. Tantawy AA, etal., Blood Coagul Fibrinolysis. 2015 Jun;26(4):419-25. doi: 10.1097/MBC.0000000000000277.
254. Endothelial nitric oxide synthase gene intron 4 VNTR polymorphism in sickle cell disease: relation to vasculopathy and disease severity. Tantawy AA, etal., Pediatr Blood Cancer. 2015 Mar;62(3):389-94. doi: 10.1002/pbc.25234. Epub 2014 Sep 27.
255. eNOS4 polymorphism of the endothelial nitric oxide synthase predicts risk for severe diabetic retinopathy. Taverna MJ, etal., Diabet Med. 2002 Mar;19(3):240-5.
256. The T-786C and C774T endothelial nitric oxide synthase gene polymorphisms independently affect the onset pattern of severe diabetic retinopathy. Taverna MJ, etal., Nitric Oxide. 2005 Aug;13(1):88-92.
257. Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice. Ten Broeke R, etal., Respir Res. 2006 Apr 5;7:58.
258. Polymorphisms in genes involved in the free-radical process in patients with sudden sensorineural hearing loss and Meniere's disease. Teranishi M, etal., Free Radic Res. 2013 Jul;47(6-7):498-506. doi: 10.3109/10715762.2013.793319. Epub 2013 May 7.
259. High-density lipoprotein administration attenuates liver proinflammatory response, restores liver endothelial nitric oxide synthase activity, and lowers portal pressure in cirrhotic rats. Thabut D, etal., Hepatology. 2007 Dec;46(6):1893-906.
260. Interleukin-6 sustains hepatic regeneration in cirrhotic rat. Tiberio GA, etal., Hepatogastroenterology. 2007 Apr-May;54(75):878-83.
261. Ethanol consumption increases blood pressure and alters the responsiveness of the mesenteric vasculature in rats. Tirapelli CR, etal., J Pharm Pharmacol. 2008 Mar;60(3):331-41.
262. Lack of association between polymorphisms of eight candidate genes and idiopathic dilated cardiomyopathy: the CARDIGENE study. Tiret L, etal., J Am Coll Cardiol. 2000 Jan;35(1):29-35.
263. Downregulation of endothelial nitric oxide synthase in rat aorta after prolonged hypoxia in vivo. Toporsian M, etal., Circ Res 2000 Mar 31;86(6):671-5.
264. Comparison of the effect of simvastatin, spironolactone and L-arginine on endothelial function of aorta in hereditary hypertriglyceridemic rats. Torok J, etal., Physiol Res. 2007;56 Suppl 2:S33-40. Epub 2007 Sep 5.
265. Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats. Tsai SK, etal., J Vasc Surg. 2007 Aug;46(2):346-53. Epub 2007 Jun 27.
266. Stromal nitric oxide synthase (NOS) expression correlates with the grade of mammary phyllodes tumour. Tse GM, etal., J Clin Pathol. 2005 Jun;58(6):600-4.
267. Oral sorbent AST-120 increases renal NO synthesis in uremic rats. Tumur Z and Niwa T, J Ren Nutr. 2008 Jan;18(1):60-4.
268. Association study of the 5' flanking regions of endothelial-nitric oxide synthase and endothelin-1 genes in familial primary open-angle glaucoma. Tunny TJ, etal., Clin Exp Pharmacol Physiol. 1998 Jan;25(1):26-9.
269. Effects of endothelial nitric oxide synthase, interleukin-6 gene polymorphisms and asymmetric dimethylarginine levels on risk factors and lesion sites in peripheral artery disease. Tuygun AK, etal., J Int Med Res. 2009 Jul-Aug;37(4):1003-10.
270. Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India. Uthra S, etal., Ophthalmic Genet. 2007 Jun;28(2):77-81.
271. The soy isoflavone genistein reverses oxidative and inflammatory state, neuropathic pain, neurotrophic and vasculature deficits in diabetes mouse model. Valsecchi AE, etal., Eur J Pharmacol. 2011 Jan 15;650(2-3):694-702. doi: 10.1016/j.ejphar.2010.10.060. Epub 2010 Nov 2.
272. Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy. Van Linthout S, etal., Diabetologia. 2007 Sep;50(9):1977-86. Epub 2007 Jun 23.
273. Nitric oxide synthase 3 contributes to ventilator-induced lung injury. Vaporidi K, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Aug;299(2):L150-9. Epub 2010 May 7.
274. Apelin as a novel drug for treating preeclampsia. Wang C, etal., Exp Ther Med. 2017 Dec;14(6):5917-5923. doi: 10.3892/etm.2017.5304. Epub 2017 Oct 13.
275. A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Wang XL, etal., Nat Med. 1996 Jan;2(1):41-5.
276. Combination analysis of NOS3, ABCB1 and IL23R polymorphisms with alcohol-induced osteonecrosis of the femoral head risk in Chinese males. Wang Y, etal., Oncotarget. 2017 May 16;8(20):33770-33778. doi: 10.18632/oncotarget.16809.
277. Thyroid hormones alter estrous cyclicity and antioxidative status in the ovaries of rats. Wei Q, etal., Anim Sci J. 2017 Dec 7. doi: 10.1111/asj.12950.
278. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics Wei W, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2007 Oct;9(5):473-8.
279. Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Wu IC, etal., Neoplasia. 2011 Apr;13(4):386-92. doi: 10.1593/neo.101722.
280. Norepinephrine-induced nociception and vasoconstrictor hypersensitivity in rats with chronic post-ischemia pain. Xanthos DN, etal., Pain. 2007 Dec 11;.
281. Hydrogen sulfide improves endothelial dysfunction in hypertension by activating peroxisome proliferator-activated receptor delta/endothelial nitric oxide synthase signaling. Xiao L, etal., J Hypertens. 2017 Oct 27. doi: 10.1097/HJH.0000000000001605.
282. Epigenetic regulation of the endothelial nitric oxide synthase gene in persistent pulmonary hypertension of the newborn rat. Xu XF, etal., J Hypertens. 2010 Nov;28(11):2227-35.
283. Propofol reduces nitric oxide-induced apoptosis in testicular ischemia-reperfusion injury by downregulating the expression of inducible nitric oxide synthase. Yagmurdur H, etal., Acta Anaesthesiol Scand. 2008 Mar;52(3):350-7. Epub 2008 Jan 16.
284. Splenic hemodynamics and decreased endothelial nitric oxide synthase in the spleen of rats with liver cirrhosis. Yamaguchi S, etal., Life Sci. 2007 May 8;80(22):2036-44. Epub 2007 Mar 23.
285. Novel allele of the endothelial nitric oxide synthase gene polymorphism in Caucasian asthmatics. Yanamandra K, etal., Biochem Biophys Res Commun. 2005 Sep 23;335(2):545-9.
286. Titanium implants alter endothelial function and vasoconstriction via a protein kinase C-regulated pathway. Yang RS, etal., Acta Biomater. 2009 Oct;5(8):3258-64. doi: 10.1016/j.actbio.2009.05.006. Epub 2009 May 13.
287. Combined preconditioning with hypoxia and GYKI-52466 protects rats from cerebral ischemic injury by HIF-1a/eNOS pathway. Yang Y, etal., Am J Transl Res. 2017 Dec 15;9(12):5308-5319. eCollection 2017.
288. Structural-Activity Relationship of Ginsenosides from Steamed Ginseng in the Treatment of Erectile Dysfunction. Ying A, etal., Am J Chin Med. 2018 Jan 3:1-19. doi: 10.1142/S0192415X18500088.
289. Phosphorylated Endothelial NOS Ser1177 via the PI3K/Akt Pathway Is Depressed in the Brain of Stroke-Prone Spontaneously Hypertensive Rat. Yoshitomi H, etal., J Stroke Cerebrovasc Dis. 2010 Aug 31.
290. Magnesium supplementation prevents chronic cyclosporine nephrotoxicity via adjusting nitric oxide synthase activity. Yuan J, etal., Transplant Proc. 2005 May;37(4):1892-5.
291. Role of Nitric Oxide Synthase in Bladder Pathologic Remodeling and Dysfunction Resulting From Partial Outlet Obstruction. Yuan X, etal., Urology. 2011 Jan 20.
292. Intestinal endotoxemia plays a central role in development of hepatopulmonary syndrome in a cirrhotic rat model induced by multiple pathogenic factors. Zhang HY, etal., World J Gastroenterol. 2007 Dec 21;13(47):6385-95.
293. Influence of L-arginine on the expression of eNOS and COX2 in experimental pulmonary thromboembolism. Zhang J, etal., J Huazhong Univ Sci Technolog Med Sci. 2006;26(5):524-7.
294. Direct effects of lead (Pb2+) on the relaxation of in vitro cultured rat aorta to acetylcholine. Zhang LF, etal., Toxicol Lett. 2007 Apr 25;170(2):104-10. Epub 2007 Feb 20.
295. Interaction of calmodulin with its binding domain of rat cerebellar nitric oxide synthase. A multinuclear NMR study. Zhang M, etal., J Biol Chem. 1995 Sep 8;270(36):20901-7.
296. Simvastatin increases circulating endothelial progenitor cells and reduces the formation and progression of diabetic retinopathy in rats. Zhang W and Yan H, Exp Eye Res. 2012 Dec;105:1-8. doi: 10.1016/j.exer.2012.09.014. Epub 2012 Oct 8.
297. Osteopontin protects against hyperoxia-induced lung injury by inhibiting nitric oxide synthases. Zhang XF, etal., Chin Med J (Engl). 2010 Apr 5;123(7):929-35.
298. Bliverdin reductase-A improves neurological function in a germinal matrix hemorrhage rat model. Zhang Y, etal., Neurobiol Dis. 2018 Feb;110:122-132. doi: 10.1016/j.nbd.2017.11.017. Epub 2017 Dec 5.
299. Radix Cyathula officinalis Kuan inhibits arterial remodeling in spontaneously hypertensive rats. Zhao J, etal., Exp Ther Med. 2017 Dec;14(6):5395-5400. doi: 10.3892/etm.2017.5218. Epub 2017 Sep 28.
300. iNOS expression in rat aorta is increased after spinal cord transection: a possible cause of orthostatic hypotension in man. Zhao J, etal., Neurosci Lett. 2007 Mar 30;415(3):210-4. Epub 2007 Jan 14.
301. Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration. Zhao YY, etal., J Clin Invest. 2009 Jul;119(7):2009-18.
302. Perturbations in Endothelial Dysfunction-Associated Pathways in the Nitrofen-Induced Congenital Diaphragmatic Hernia Model. Zhaorigetu S, etal., J Vasc Res. 2017 Dec 8;55(1):26-34. doi: 10.1159/000484087.
303. Phytoestrogen alpha-zearalanol improves vascular function in ovariectomized hyperhomocysteinemic rats. Zhen PP, etal., Atherosclerosis. 2011 Apr;215(2):309-15. doi: 10.1016/j.atherosclerosis.2010.12.029. Epub 2011 Jan 19.
304. Down-regulation of renal endothelial nitric oxide synthase expression in experimental glomerular thrombotic microangiopathy. Zhou XJ, etal., Lab Invest. 2000 Jul;80(7):1079-87.
305. Cryptotanshinone exhibits therapeutical effects on cerebral stroke through the PI3K/AKT-eNOS signaling pathway. Zhu W, etal., Mol Med Rep. 2017 Dec;16(6):9361-9366. doi: 10.3892/mmr.2017.7824. Epub 2017 Oct 19.
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