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Gene: Cav2 (caveolin 2) Rattus norvegicus
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Symbol: Cav2
Name: caveolin 2
RGD ID: 620348
Description: Exhibits mitogen-activated protein kinase kinase kinase binding activity; phosphoprotein binding activity; and syntaxin binding activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of endothelial cell proliferation; and positive regulation of protein phosphorylation. Localizes to several cellular components, including caveola; lipid droplet; and nuclear inner membrane. Predicted to colocalize with focal adhesion and sarcolemma. Biomarker of malignant glioma and obesity. Human ortholog(s) of this gene implicated in low tension glaucoma and primary open angle glaucoma. Orthologous to human CAV2 (caveolin 2); PARTICIPATES IN reverse cholesterol transport pathway; syndecan signaling pathway; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: caveolin-2; MGC72322
Orthologs:
Homo sapiens (human) : CAV2 (caveolin 2)  HGNC  Alliance
Mus musculus (house mouse) : Cav2 (caveolin 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cav2 (caveolin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CAV2 (caveolin 2)
Canis lupus familiaris (dog) : CAV2 (caveolin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cav2 (caveolin 2)
Sus scrofa (pig) : CAV2 (caveolin 2)
Chlorocebus sabaeus (African green monkey) : CAV2 (caveolin 2)
Heterocephalus glaber (naked mole-rat) : Cav2 (caveolin 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0444,573,264 - 44,580,640 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl444,573,264 - 44,580,638 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0445,178,080 - 45,186,997 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4442,932,127 - 42,939,503 (+)NCBIRGSC3.4rn4RGSC3.4
Celera440,892,754 - 40,900,130 (+)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cav2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620348
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.