Mapk3 (mitogen activated protein kinase 3) - Rat Genome Database

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Gene: Mapk3 (mitogen activated protein kinase 3) Rattus norvegicus
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Symbol: Mapk3
Name: mitogen activated protein kinase 3
RGD ID: 3046
Description: Enables ATP binding activity; MAP kinase activity; and scaffold protein binding activity. Involved in several processes, including arachidonate metabolic process; decidualization; and peptidyl-serine phosphorylation. Located in caveola; cytoplasm; and nucleoplasm. Part of protein-containing complex. Used to study several diseases, including alcohol dependence; cocaine abuse; drug dependence (multiple); gastric ulcer; and middle cerebral artery infarction. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in Parkinson's disease; carcinoma (multiple); and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ceramide signaling pathway; endothelin signaling pathway; INTERACTS WITH (+)-catechin; (+)-dihydromyricetin; (+)-pilocarpine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Erk-1; ERK1; ERT2; Esrk1; extracellular signal-regulated kinase 1; extracellular-signal-regulated kinase 1; insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAPK 1; MAPK 3; MAPK1; microtubule-associated protein 2 kinase; mitogen activated kinase 3; mitogen-activated 3; mitogen-activated 3 (MAP kinase 3, p44); mitogen-activated protein kinase 1; mitogen-activated protein kinase 3; MNK1; p44; p44-ERK1; p44-MAPK; p44erk1; p44mapk; Prkm3; Protein kinase mitogen activated 3 (extracellular-signal-regulated kinase 1 ERK1); Protein kinase, mitogen activated 3 (extracellular-signal-regulated kinase 1, ERK1)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,797,189 - 190,803,411 (+)NCBIGRCr8
mRatBN7.21181,366,646 - 181,372,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,366,637 - 181,372,863 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,717,952 - 189,724,168 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,904,026 - 196,910,242 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,571,369 - 189,577,596 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,192,773 - 198,198,975 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,192,773 - 198,198,975 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,172,641 - 205,178,843 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,935,044 - 185,941,245 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,084,924 - 186,091,127 (+)NCBI
Celera1179,022,318 - 179,028,386 (+)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
alcohol dependence  (IDA)
alcohol use disorder  (IEP)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
Atrophy  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
brain ischemia  (ISO)
cardiomyopathy  (ISO)
chromosome 16p11.2 deletion syndrome, 593-kb  (ISO)
chromosome 16p11.2 duplication syndrome  (ISO)
cocaine abuse  (IDA)
cocaine dependence  (IDA)
Cocaine-Related Disorders  (ISO)
colon adenocarcinoma  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Coronavirus infectious disease  (ISO)
coronin-1A deficiency  (ISO)
Developmental Disabilities  (ISO)
Diabetic Cardiomyopathies  (IDA)
dilated cardiomyopathy  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
Episodic Kinesigenic Dyskinesia  (ISO)
episodic kinesigenic dyskinesia 1  (ISO)
Experimental Colitis  (IDA)
Experimental Diabetes Mellitus  (IDA)
Experimental Liver Cirrhosis  (IEP)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IDA)
Experimental Radiation Injuries  (ISO)
extrahepatic cholestasis  (ISO)
Female Infertility  (ISO)
gastric ulcer  (IDA)
Gliosis  (ISO)
Glycogen Storage Disease XII  (ISO)
Head and Neck Neoplasms  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (ISO)
Hypertrophy  (ISO)
Insulin Resistance  (IDA)
Kidney Neoplasms  (ISO)
Lung Neoplasms  (ISO)
Memory Disorders  (IDA,ISO)
middle cerebral artery infarction  (IDA)
morphine dependence  (IDA,ISO)
Myocardial Reperfusion Injury  (IDA,IEP)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
Neurodevelopmental Disorders  (ISO)
neuronal ceroid lipofuscinosis 6A  (ISO)
obesity  (ISO)
Osteoarthritis, Experimental  (IEP)
Ovarian Neoplasms  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
Pneumococcal Pneumonia  (ISO)
Postoperative Cognitive Dysfunction  (IDA,ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Shock  (IDA)
spondylocostal dysostosis 5  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Testis Reperfusion Injury  (IMP)
trigeminal neuralgia  (ISO)
type 2 diabetes mellitus  (IDA,ISO)
ureteral obstruction  (IDA)
withdrawal disorder  (IDA,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (EXP,ISO)
(+)-dihydromyricetin  (EXP)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-Pimaric acid  (ISO)
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (EXP,ISO)
(-)-anisomycin  (EXP,ISO)
(-)-Arctigenin  (ISO)
(-)-citrinin  (EXP,ISO)
(-)-cotinine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-lobeline  (ISO)
(-)-matairesinol  (ISO)
(-)-selegiline  (EXP,ISO)
(-)-trans-epsilon-viniferin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(1S)-bornane-2,3-dione  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione  (EXP)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-3,5-dihydroxyphenylglycine  (EXP,ISO)
(S)-amphetamine  (EXP,ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(S)-timolol (anhydrous)  (EXP,ISO)
(Z)-ligustilide  (EXP)
1'-acetoxychavicol acetate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,2-naphthoquinone  (ISO)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,3-dinitrobenzene  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,4-naphthoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (EXP,ISO)
14,15-EET  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17-hydroxyjolkinolide B  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,4'-tetrachlorobiphenyl  (EXP,ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3',5-trichlorobiphenyl  (EXP)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline  (ISO)
2,4,6-tribromophenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-aminobiphenyl  (ISO)
2-aminopurine  (ISO)
2-arachidonoylglycerol  (EXP,ISO)
2-chloroethanol  (EXP)
2-deoxy-D-glucose  (EXP,ISO)
2-methoxyethanol  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (EXP,ISO)
2-methylcholine  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
26-hydroxycholesterol  (ISO)
3',4'-dimethoxyflavone  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5,5'-tetraiodothyroacetic acid  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3,5-dichlorobiphenyl  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-bromopyruvic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-Methoxynobiletin  (ISO)
3-methyladenine  (ISO)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (EXP)
3-O-Caffeoyl-1-O-methylquinic acid  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,4'-thiodiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-aminopyridine  (EXP,ISO)
4-chlorobiphenyl  (EXP)
4-ethylphenol  (EXP,ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methoxy-TEMPO  (ISO)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (EXP,ISO)
4-phenylbutyric acid  (EXP,ISO)
4-Propylphenol  (EXP,ISO)
4-tert-Octylphenol  (ISO)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (EXP)
5,7-dihydroxy-4'-methoxyflavone  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aminolevulinic acid  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
5-methoxypsoralen  (ISO)
6,7-dimethoxy-2-phenylquinoxaline  (ISO)
6-aminohexanoate  (ISO)
6-aminohexanoic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-Cyano-7-nitroquinoxaline-2,3-dione  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-dihydroxycoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
7-ketocholesterol  (EXP,ISO)
7alpha-hydroxycholesterol  (ISO)
8-Br-cAMP  (EXP,ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinoic acid  (EXP,ISO)
[6]-Shogaol  (ISO)
AACOCF3  (ISO)
acadesine  (EXP)
acamprosate  (ISO)
acebutolol  (ISO)
acetaldehyde  (EXP,ISO)
acetic acid  (EXP)
acetochlor  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (EXP)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
Actein  (ISO)
acteoside  (ISO)
actinomycin D  (EXP,ISO)
adenosine  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (EXP)
ADP  (ISO)
afimoxifene  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
AICA ribonucleotide  (EXP,ISO)
AL 8810  (ISO)
albuterol  (EXP,ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
aldrithiol  (EXP)
alendronic acid  (ISO)
Alisol B  (ISO)
alizarin  (ISO)
all-trans-acitretin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allethrin  (EXP)
allicin  (ISO)
allopurinol  (ISO)
alloxan  (EXP)
allyl isothiocyanate  (ISO)
Allylamine  (EXP)
alpha-D-galactose  (EXP)
alpha-mangostin  (ISO)
alpha-melanocyte stimulating hormone  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (ISO)
alprenolol  (ISO)
aluminium atom  (EXP)
aluminium hydroxide  (ISO)
aluminium(0)  (EXP)
alvocidib  (ISO)
AM-251  (ISO)
amentoflavone  (ISO)
amidotrizoic acid  (ISO)
amiloride  (ISO)
amino acid  (ISO)
aminoguanidine  (EXP)
amiodarone  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amodiaquine  (ISO)
amosite asbestos  (EXP,ISO)
amosulalol  (EXP)
amoxicillin  (ISO)
amphetamine  (EXP,ISO)
amphibole asbestos  (EXP,ISO)
ampicillin  (EXP)
amsacrine  (ISO)
anandamide  (EXP,ISO)
andrographolide  (ISO)
Anemoside B4  (ISO)
anethole  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antigen  (ISO)
antimonite  (ISO)
antimony trichloride  (ISO)
antimony(0)  (EXP)
antimycin A  (ISO)
Antrocin  (ISO)
antroquinonol  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
arachidonic acid  (EXP,ISO)
arachidonyl-2'-chloroethylamide  (EXP,ISO)
Arctiin  (ISO)
arecoline  (EXP,ISO)
Arg-Gly-Asp  (EXP,ISO)
aristolochic acid A  (ISO)
aristolochic acids  (ISO)
arjunolic acid  (EXP)
Aroclor 1254  (EXP)
ARS-1620  (ISO)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
aspalathin  (ISO)
aspartame  (ISO)
astaxanthin  (ISO)
astilbin  (ISO)
astragaloside IV  (ISO)
astressin  (EXP)
atenolol  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
atrasentan  (EXP)
atrazine  (EXP,ISO)
atropine  (EXP)
aucubin  (ISO)
auranofin  (ISO)
aureusidin  (EXP)
Auriculasin  (ISO)
avermectin  (ISO)
avobenzone  (ISO)
axitinib  (ISO)
azadirachtin A  (ISO)
azathioprine  (ISO)
AZD4547  (ISO)
azetidine  (ISO)
Azoxymethane  (ISO)
baclofen  (EXP)
bafilomycin A1  (ISO)
baicalein  (ISO)
baicalin  (EXP)
BAPTA  (ISO)
bathocuproine disulfonic acid  (EXP,ISO)
batimastat  (ISO)
BAY 60-6583  (ISO)
beauvericin  (EXP)
benzamide  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[e]pyrene  (ISO)
benzofurans  (ISO)
benzyl isothiocyanate  (ISO)
berberine  (EXP,ISO)
Bergenin  (ISO)
beryllium difluoride  (ISO)
beta-carotene  (EXP,ISO)
beta-cyclodextrin  (ISO)
beta-D-fructofuranose 1,6-bisphosphate  (ISO)
beta-D-glucosamine  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-endorphin  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-ionone  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
betulin  (EXP,ISO)
betulinic acid  (ISO)
bezafibrate  (EXP)
bicalutamide  (ISO)
bicuculline  (EXP,ISO)
bifenthrin  (ISO)
bilirubin IXalpha  (ISO)
bilobalide  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
bortezomib  (ISO)
Botulinum toxin type A  (EXP)
brefeldin A  (EXP)
bromocriptine  (EXP)
Bruceantinol  (ISO)
bucladesine  (ISO)
bufalin  (ISO)
bupivacaine  (ISO)
buprenorphine  (ISO)
busulfan  (ISO)
butan-1-ol  (EXP,ISO)
butane-2,3-dione  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium sulfate  (EXP,ISO)
cadmium telluride  (ISO)
caffeine  (ISO)
calcidiol  (ISO)
Calcimycin  (EXP,ISO)
calcitriol  (ISO)
calcium atom  (EXP,ISO)
calcium dichloride  (EXP,ISO)
calcium silicate  (ISO)
calcium(0)  (EXP,ISO)
Calphostin C  (EXP,ISO)
calycosin  (ISO)
camostat  (ISO)
camptothecin  (ISO)
candesartan  (EXP)
canertinib  (ISO)
cannabidiol  (ISO)
cantharidic acid  (ISO)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
capsanthin  (EXP)
capsazepine  (EXP,ISO)
captan  (ISO)
carbachol  (EXP,ISO)
carbendazim  (ISO)
CARBENOXOLONE  (ISO)
carbon dioxide  (EXP)
carbon nanotube  (ISO)
Carnosol  (ISO)
carrageenan  (ISO)
carteolol  (ISO)
carvedilol  (EXP,ISO)
Cassine  (ISO)
cefaloridine  (EXP)
celastrol  (EXP)
celecoxib  (EXP,ISO)
ceric oxide  (ISO)
ceritinib  (ISO)
cetrorelix  (ISO)
CGP 12177  (ISO)
chaetocin  (ISO)
chaetoglobosin A  (EXP,ISO)
chalcone  (ISO)
chelerythrine  (EXP,ISO)
chenodeoxycholic acid  (ISO)
chitosan  (EXP,ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
cholic acid  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (ISO)
chrysophanol  (ISO)
ciclopirox  (ISO)
ciglitazone  (EXP,ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clopidogrel  (ISO)
clothianidin  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobimetinib  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
compound 48/80  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
corn oil  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP,ISO)
cortisone  (ISO)
coumestrol  (EXP)
crizotinib  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (EXP,ISO)
CU-O LINKAGE  (ISO)
cucurbitacin E  (EXP)
cudraflavone B  (ISO)
cudratricusxanthone A  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
Cyclosporin H  (ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (ISO)
cyproconazole  (ISO)
cyprodinil  (ISO)
cytochalasin B  (ISO)
D-aspartic acid  (EXP,ISO)
D-cycloserine  (EXP)
D-fructofuranose 1,6-bisphosphate  (ISO)
D-glucose  (EXP,ISO)
dabrafenib  (ISO)
dacarbazine  (ISO)
dactolisib  (ISO)
daidzein  (EXP,ISO)
dapsone  (ISO)
daunorubicin  (EXP,ISO)
DDE  (EXP,ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
Decursin  (ISO)
deferiprone  (EXP,ISO)
deguelin  (ISO)
dehydroacetic acid  (EXP)
delphinidin  (ISO)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
desferrioxamine B  (EXP,ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
dextromethorphan  (ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP,ISO)
diazinon  (EXP,ISO)
dibenziodolium  (EXP,ISO)
dibenzo[a,l]pyrene  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
diclofenac  (ISO)
dicoumarol  (ISO)
Dictamnine  (ISO)
Dicyclohexyl phthalate  (EXP)
Didymin  (ISO)
dieckol  (ISO)
dieldrin  (EXP,ISO)
diepoxybutane  (ISO)
diethyl malate  (ISO)
diethyl phthalate  (ISO)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
digoxin  (EXP)
dihydroartemisinin  (ISO)
dihydrocapsaicin  (ISO)
dihydrolipoic acid  (EXP)
Dihydrotanshinone I  (ISO)
dihydroxyacetone  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
diltiazem  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
diminazene diaceturate  (ISO)
dinaciclib  (ISO)
Dinitramine  (ISO)
dinitrogen  (ISO)
dioscin  (EXP,ISO)
diosmetin  (ISO)
dioxygen  (EXP,ISO)
diphenyl diselenide  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
diquat  (ISO)
disodium cromoglycate  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
divanadium pentaoxide  (ISO)
dizocilpine maleate  (EXP,ISO)
dobutamine  (EXP,ISO)
donepezil hydrochloride  (EXP)
dopamine  (EXP,ISO)
dorsomorphin  (EXP,ISO)
doxazosin  (EXP)
doxorubicin  (EXP,ISO)
DPCPX  (EXP)
ebselen  (EXP,ISO)
eckol  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
ellipticine  (ISO)
emetine  (ISO)
emodin  (EXP,ISO)
endosulfan  (EXP,ISO)
enzacamene  (ISO)
enzyme inhibitor  (ISO)
eplerenone  (ISO)
equol  (ISO)
erastin  (ISO)
erdosteine  (EXP)
erlotinib hydrochloride  (EXP,ISO)
Erucin  (ISO)
esculetin  (EXP,ISO)
estragole  (EXP)
estriol  (EXP,ISO)
estrogen  (EXP)
estrone  (EXP,ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ether  (EXP)
Ethyl pyruvate  (EXP,ISO)
ethyl trans-caffeate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
eticlopride(1+)  (ISO)
etoposide  (ISO)
etoxazole  (ISO)
EUK-134  (ISO)
Evodiamine  (EXP,ISO)
excitatory amino acid agonist  (EXP,ISO)
famotidine  (ISO)
farnesyl diphosphate  (ISO)
farrerol  (EXP,ISO)
fenbuconazole  (ISO)
fenoterol  (ISO)
fentanyl  (ISO)
fenthion  (ISO)
fenvalerate  (EXP,ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (EXP,ISO)
ferroheme b  (ISO)
ferrosoferric oxide  (ISO)
ferulic acid  (EXP,ISO)
Fexofenadine hydrochloride  (ISO)
Fidarestat  (ISO)
filipin III  (EXP)
fingolimod hydrochloride  (ISO)
fipronil  (ISO)
fisetin  (EXP,ISO)
flavanones  (ISO)
flavonol  (ISO)
flavonols  (ISO)
flufenoxuron  (ISO)
fluoranthene  (ISO)
fluorescein 5-isothiocyanate  (ISO)
fluoxetine  (EXP,ISO)
fluprostenol  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
fomepizole  (ISO)
formaldehyde  (ISO)
formononetin  (ISO)
formoterol fumarate  (ISO)
FR900359  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
Fulvic acid  (ISO)
furan  (EXP,ISO)
gadodiamide hydrate  (ISO)
gadolinium atom  (EXP)
gadolinium trichloride  (EXP,ISO)
galactose  (EXP)
galangin  (EXP)
gallein  (EXP)
gallic acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
gamma-linolenic acid  (ISO)
Garcinol  (ISO)
gefitinib  (EXP,ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
Genipin  (ISO)
Geniposide pentaacetate  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
Gentiopicrin  (ISO)
Geraniin  (ISO)
geraniol  (EXP,ISO)
GGTI-2133  (EXP)
Gingerenone A  (EXP,ISO)
ginkgolide B  (ISO)
ginsenoside Rd  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
Ginsenoside Rh4  (EXP)
Glabrene  (ISO)
glabridin  (ISO)
gliclazide  (EXP)
gliotoxin  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glyburide  (EXP)
glycine  (EXP)
glycitein  (ISO)
glycochenodeoxycholic acid  (EXP,ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP,ISO)
Goe 6976  (EXP,ISO)
gossypol  (ISO)
guanosine  (ISO)
GW 1929  (ISO)
haloperidol  (ISO)
halothane  (ISO)
harmine  (ISO)
helioxanthin  (ISO)
heme b  (ISO)
hemin  (ISO)
heparan sulfate  (ISO)
heparin  (EXP,ISO)
heptachlor  (EXP,ISO)
herbicide  (EXP)
herbimycin  (ISO)
hesperetin  (ISO)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (EXP,ISO)
Hexamethonium  (ISO)
hexamethylene diisocyanate  (ISO)
high-density lipoprotein cholesterol  (ISO)
hinokiflavone  (ISO)
hispidulin  (EXP,ISO)
histamine  (EXP,ISO)
homocysteine  (ISO)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydralazine  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxyflutamide  (EXP,ISO)
hydroxytyrosol  (ISO)
hydroxyurea  (EXP)
hyperforin  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (ISO)
IC-87114  (ISO)
icariin  (EXP,ISO)
icariside II  (ISO)
icatibant  (ISO)
ICI 118551  (EXP,ISO)
ICI-164384  (ISO)
icosanoid  (ISO)
Ilimaquinone  (ISO)
iloprost  (ISO)
imidacloprid  (ISO)
imipramine  (EXP)
imiquimod  (ISO)
imperatorin  (ISO)
indapamide  (EXP)
indole-3-methanol  (ISO)
indometacin  (ISO)
indoprofen  (ISO)
indoxyl sulfate  (ISO)
Inotodiol  (ISO)
iohexol  (ISO)
ionomycin  (EXP,ISO)
iopromide  (ISO)
Ioversol  (ISO)
ioxynil  (EXP)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP,ISO)
iron dichloride  (ISO)
iron trichloride  (EXP)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isocarbophos  (ISO)
isoeugenol  (ISO)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isoorientin  (ISO)
isoprenaline  (EXP,ISO)
isoprene  (ISO)
isorhapontigenin  (EXP)
isothiocyanate  (ISO)
ivermectin  (ISO)
JTE-013  (ISO)
juglone  (ISO)
Jujuboside A  (ISO)
kaempferol  (EXP,ISO)
kahweol  (ISO)
kainic acid  (ISO)
ketamine  (ISO)
ketanserin  (ISO)
keto-D-fructose 1,6-bisphosphate  (ISO)
KN-93  (EXP,ISO)
kojic acid  (ISO)
KT 5720  (ISO)
KT 5823  (EXP,ISO)
Kukoamine B  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP)
L-cystine  (ISO)
L-glutamic acid  (EXP,ISO)
L-methionine  (EXP,ISO)
labetalol  (ISO)
lactacystin  (ISO)
lactucin  (ISO)
lansoprazole  (EXP)
lapatinib  (ISO)
latrunculin B  (EXP)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
lentinan  (ISO)
leptomycin B  (ISO)
lercanidipine  (EXP,ISO)
letrozole  (ISO)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
leukotriene D4  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
Liensinine  (ISO)
linalool  (ISO)
linoleic acid  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lipoxin A4  (ISO)
lithium atom  (ISO)
lithium chloride  (EXP)
lithium hydride  (ISO)
lithocholic acid  (ISO)
LM-1685  (ISO)
loliolide  (ISO)
lonidamine  (ISO)
loperamide  (ISO)
losartan  (EXP,ISO)
lovastatin  (EXP,ISO)
loxoprofen  (ISO)
Lupalbigenin  (ISO)
luteolin  (EXP,ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY 117018  (ISO)
LY 379268  (EXP)
LY294002  (EXP,ISO)
lycopene  (ISO)
lysophosphatidylcholine  (EXP)
Maduramicin  (EXP)
Magnolol  (EXP,ISO)
Malonoben  (ISO)
malvidin  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
manumycin A  (EXP)
Maprotiline  (ISO)
marimastat  (EXP)
masoprocol  (ISO)
mebendazole  (ISO)
Mecamylamine  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
melamine  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
meloxicam  (ISO)
melphalan  (ISO)
memantine  (EXP)
menadione  (EXP,ISO)
mepyramine  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
metacetamol  (ISO)
metam  (ISO)
metformin  (EXP,ISO)
methadone  (ISO)
methamphetamine  (ISO)
Methanandamide  (EXP,ISO)
methapyrilene  (EXP,ISO)
methimazole  (EXP,ISO)
methoctramine tetrahydrochloride  (EXP)
methohexital  (ISO)
methotrexate  (EXP)
methoxyacetic acid  (ISO)
methoxychlor  (EXP,ISO)
methyl beta-cyclodextrin  (ISO)
methyl caffeate  (ISO)
methyl tert-butyl ether  (EXP)
methylglyoxal  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
Methylthiouracil  (ISO)
metronidazole  (EXP)
mevalonic acid  (EXP,ISO)
microcystin-LR  (ISO)
midazolam  (ISO)
midostaurin  (ISO)
mifepristone  (EXP,ISO)
minocycline  (ISO)
mitomycin C  (ISO)
MitoTEMPO  (ISO)
MK 571  (ISO)
MK-2206  (ISO)
ML-7  (ISO)
mocetinostat  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (EXP)
monodansylcadaverine  (ISO)
montelukast  (ISO)
morin  (EXP)
morphine  (EXP,ISO)
Morroniside  (EXP)
morusin  (ISO)
moxifloxacin  (ISO)
Muconic dialdehyde  (EXP)
muscimol  (EXP)
mycophenolic acid  (ISO)
myo-inositol hexakisphosphate  (EXP,ISO)
myricetin  (ISO)
myricitrin  (ISO)
N(6)-butyryl-cAMP  (ISO)
N,N'-diphenyl-1,4-phenylenediamine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylformamide  (ISO)
N,O-dimethyltyramine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (EXP)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylnicotinate  (ISO)
N-Nitroso-N-methylurethane  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-phenylthiourea  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (EXP,ISO)
naringin  (EXP,ISO)
nefazodone  (ISO)
Neferine  (ISO)
neoastilbin  (ISO)
neocuproine  (EXP)
neomycin  (EXP,ISO)
nerolidol  (EXP)
nicardipine  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nifedipine  (ISO)
nimesulide  (ISO)
nimodipine  (ISO)
nimustine  (ISO)
nintedanib  (ISO)
nitric oxide  (EXP)
nitroprusside  (EXP,ISO)
NMN zwitterion  (ISO)
nocodazole  (EXP,ISO)
Nodularin  (EXP)
nonanedioic acid  (ISO)
Nonylphenol  (EXP,ISO)
Nookatone  (EXP)
norathyriol  (ISO)
Norbinaltorphimine  (ISO)
NORCANTHARIDIN  (ISO)
notoginsenoside R1  (EXP,ISO)
NS-398  (EXP,ISO)
nystatin  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP,ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oleuropein  (ISO)
oligopeptide  (ISO)
olmesartan  (ISO)
omacetaxine mepesuccinate  (ISO)
omipalisib  (ISO)
organoselenium compound  (EXP)
orlistat  (ISO)
oroxylin A  (ISO)
osimertinib  (ISO)
osthole  (ISO)
ouabain  (EXP,ISO)
oxaliplatin  (EXP,ISO)
oxidopamine  (EXP,ISO)
oxycodone  (EXP)
oxytocin  (EXP)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (ISO)
palmatine  (EXP)
palytoxin  (ISO)
pamoic acid  (ISO)
Panaxynol  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parecoxib  (ISO)
paroxetine  (ISO)
Parthenin  (ISO)
patchouli alcohol  (ISO)
patulin  (EXP,ISO)
pazopanib  (ISO)
PCB138  (ISO)
PD 0325901  (EXP,ISO)
PD 168393  (ISO)
PD123319  (ISO)
PD173074  (EXP,ISO)
pelargonidin  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (EXP,ISO)
Pentoxifylline  (ISO)
peptidoglycan  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluoroheptanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
perifosine  (ISO)
perillyl alcohol  (ISO)
permethrin  (EXP,ISO)
peroxides  (EXP)
peroxynitrous acid  (EXP)
PF-3758309  (ISO)
PHA-665752  (ISO)
phenanthrolines  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenols  (ISO)
phentolamine  (ISO)
phenylarsine oxide  (EXP,ISO)
phenylephrine  (EXP,ISO)
phenytoin  (ISO)
PhIP  (ISO)
phloretin  (EXP)
phlorizin  (ISO)
phlorizin chalcone  (ISO)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (EXP)
phosphatidic acid  (ISO)
phosphoramidon  (ISO)
phylloquinone  (ISO)
phytol  (ISO)
phytosphingosine  (ISO)
picoxystrobin  (ISO)
picropodophyllotoxin  (ISO)
Picroside ii  (ISO)
picrotoxin  (EXP)
picrotoxinin  (ISO)
pifithrin-alpha hydrobromide  (EXP,ISO)
pindolol  (ISO)
pinocembrin  (ISO)
pioglitazone  (EXP,ISO)
piperine  (ISO)
pipoxolan  (ISO)
Pirarubicin  (EXP)
pirinixic acid  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
platycodin D  (EXP,ISO)
plumbagin  (ISO)
poly(I:C)  (ISO)
poly(vinylpyrrolidone)  (ISO)
Polygodial  (EXP)
polymyxin B2  (ISO)
polyphosphates  (ISO)
ponatinib  (ISO)
potassium atom  (EXP)
potassium bromate  (ISO)
potassium chloride  (EXP)
potassium dichromate  (EXP,ISO)
practolol  (ISO)
Praeruptorin A  (ISO)
prazosin  (EXP,ISO)
prednisolone  (EXP)
prednisone  (ISO)
probenecid  (EXP)
procaine  (ISO)
prochloraz  (ISO)
procyanidin B2  (ISO)
prodigiosin  (ISO)
progesterone  (EXP,ISO)
promegestone  (EXP,ISO)
propacetamol  (ISO)
propane-1,2-diol  (ISO)
propazine  (ISO)
propiconazole  (ISO)
propofol  (EXP,ISO)
propranolol  (EXP,ISO)
propylparaben  (ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (EXP,ISO)
prostaglandin I2  (ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
pyocyanine  (ISO)
pyrazines  (ISO)
pyridazines  (ISO)
Pyridostigmine bromide  (EXP)
pyrithione  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrroloquinoline quinone  (ISO)
quercetagetin  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinacrine  (ISO)
quinazolines  (ISO)
quinpirole  (ISO)
quizartinib  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (ISO)
razoxane  (EXP)
reactive oxygen species  (EXP,ISO)
Rebamipide  (ISO)
regorafenib  (ISO)
reparixin  (ISO)
resiniferatoxin  (ISO)
resveratrol  (EXP,ISO)
RGFP966  (ISO)
rimonabant  (EXP,ISO)
Risedronate sodium  (ISO)
Ro 31-8220  (EXP,ISO)
roflumilast  (ISO)
rolipram  (EXP)
romidepsin  (ISO)
ropinirole  (ISO)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
Ruscogenin  (ISO)
ruthenium red  (EXP,ISO)
rutin  (EXP,ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
Salidroside  (ISO)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (ISO)
Sanggenon C  (ISO)
sanguinarine  (ISO)
sapanisertib  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SB-239063  (EXP)
SCH 23390  (ISO)
SCH772984  (EXP,ISO)
sclareol  (ISO)
scopoletin  (EXP)
secobarbital  (ISO)
selenic acid  (ISO)
selenium atom  (EXP,ISO)
selenocystine  (ISO)
selenomethionine  (ISO)
selumetinib  (ISO)
semilicoisoflavone B  (ISO)
sepantronium  (ISO)
serotonin  (ISO)
serpentine asbestos  (EXP,ISO)
sertraline  (EXP,ISO)
sevoflurane  (EXP,ISO)
Shikonin  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silmitasertib  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simazine  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
SKF-96365 hydrochloride  (ISO)
SL-327  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chlorate  (ISO)
sodium chloride  (EXP,ISO)
sodium cholate  (ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
Sodium salicylate  (EXP,ISO)
Soman  (EXP)
sorafenib  (EXP,ISO)
sorbinil  (ISO)
sotorasib  (ISO)
sotrastaurin  (ISO)
sphingosine 1-phosphate  (EXP,ISO)
SR 144528  (ISO)
staurosporine  (EXP,ISO)
StemRegenin 1  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
SU6656  (ISO)
sucrose  (EXP,ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (EXP)
sulfonyldimethane  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
suramin  (EXP,ISO)
surfactin  (ISO)
surfactin C  (ISO)
suvorexant  (ISO)
swainsonine  (ISO)
Swertiamarin  (ISO)
syringic acid  (ISO)
tadalafil  (ISO)
taiwanin C  (ISO)
tamibarotene  (EXP,ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (EXP,ISO)
taurine  (EXP,ISO)
taurocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tazarotene  (ISO)
tebufenpyrad  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
tephrosin  (ISO)
terbinafine  (ISO)
terbutaline  (EXP,ISO)
terbutylazine  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetracaine  (EXP)
Tetrachlorobisphenol A  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraethylammonium  (EXP)
tetramethylpyrazine  (ISO)
tetrathiomolybdate(2-)  (EXP,ISO)
tetrodotoxin  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (EXP,ISO)
theophylline  (ISO)
thiamylal  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
Thiorphan  (ISO)
thiostrepton  (ISO)
Thrombin  (ISO)
thymoquinone  (EXP,ISO)
thyroxine  (EXP,ISO)
tibolone  (ISO)
tipifarnib  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
tomatidine  (ISO)
Tomentosin  (ISO)
toosendanin  (ISO)
trametinib  (ISO)
trans-anethole  (ISO)
trans-caffeic acid  (ISO)
trans-chalcone  (ISO)
trans-isoeugenol  (ISO)
trans-piceid  (ISO)
triadimefon  (EXP)
tributylstannane  (EXP,ISO)
tributyrin  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trifluoperazine  (EXP,ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (ISO)
tubocurarine  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (EXP,ISO)
Typhaneoside  (EXP)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (EXP,ISO)
U0126  (EXP)
U69593  (ISO)
UDP  (ISO)
umbelliferone  (EXP)
urethane  (EXP,ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (EXP)
Ursonic acid  (ISO)
usnic acid  (ISO)
UTP  (EXP,ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vanadium atom  (EXP,ISO)
vanadium(0)  (EXP,ISO)
vanadyl sulfate  (ISO)
vancomycin  (EXP)
varenicline  (ISO)
vecuronium bromide  (ISO)
vemurafenib  (ISO)
venetoclax  (ISO)
venlafaxine hydrochloride  (EXP)
verapamil  (ISO)
Vernodalin  (ISO)
vildagliptin  (ISO)
vinclozolin  (EXP)
vitamin D  (EXP)
vitamin E  (ISO)
Vitisin A  (EXP,ISO)
vorinostat  (ISO)
warfarin  (ISO)
WIN 55212-2  (EXP,ISO)
withaferin A  (ISO)
Withanone  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
Xamoterol  (ISO)
xanthohumol  (ISO)
xanthones  (ISO)
xenon atom  (EXP)
xenon(0)  (EXP)
xestospongin C  (ISO)
XMU-MP-1  (ISO)
Y-27632  (EXP,ISO)
YM-254890  (ISO)
zearalenone  (EXP,ISO)
zebularine  (ISO)
zerumbone  (ISO)
zileuton  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
apoptotic process  (IEA)
arachidonate metabolic process  (IEP)
Bergmann glial cell differentiation  (ISO)
BMP signaling pathway  (ISO)
cardiac neural crest cell development involved in heart development  (ISO)
cartilage development  (ISO)
caveolin-mediated endocytosis  (IEA,TAS)
cell surface receptor signaling pathway  (IBA)
cellular response to amino acid starvation  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to toxic substance  (IDA)
cellular response to tumor necrosis factor  (ISO)
decidualization  (IDA)
DNA damage response  (ISO)
DNA-templated transcription  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
ERBB2-ERBB3 signaling pathway  (ISO)
ERK1 and ERK2 cascade  (ISO)
face development  (ISO)
insulin receptor signaling pathway  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
interleukin-1-mediated signaling pathway  (ISO)
intracellular signal transduction  (IBA,IDA,TAS)
JNK cascade  (IEA)
lipopolysaccharide-mediated signaling pathway  (ISO)
lung morphogenesis  (ISO)
MAPK cascade  (IEA,IMP,ISO)
modulation of chemical synaptic transmission  (ISO)
myelination  (ISO)
negative regulation of TORC1 signaling  (ISO)
neural crest cell development  (ISO)
outer ear morphogenesis  (ISO)
peptidyl-serine phosphorylation  (IMP)
peptidyl-tyrosine autophosphorylation  (ISO)
phosphorylation  (ISO)
positive regulation of cyclase activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of macrophage proliferation  (ISO)
positive regulation of telomere maintenance  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of translation  (IMP)
positive regulation of xenophagy  (ISO)
protein phosphorylation  (IDA,ISO,TAS)
protein-containing complex assembly  (IMP)
regulation of cellular pH  (ISO)
regulation of cytoskeleton organization  (IEA,TAS)
regulation of DNA-binding transcription factor activity  (ISO)
regulation of early endosome to late endosome transport  (IEA,TAS)
regulation of Golgi inheritance  (IEA,TAS)
regulation of ossification  (ISO)
regulation of stress-activated MAPK cascade  (IEA,TAS)
response to epidermal growth factor  (ISO,ISS)
response to exogenous dsRNA  (ISO)
response to lipopolysaccharide  (ISO)
response to toxic substance  (IDA)
Schwann cell development  (ISO)
sensory perception of pain  (ISO)
signal transduction in response to DNA damage  (ISO)
stress-activated MAPK cascade  (ISO)
thymus development  (ISO)
thyroid gland development  (ISO)
trachea formation  (ISO)
xenophagy  (ISO)

Cellular Component
caveola  (IDA,IEA,TAS)
ciliary basal body  (ISO)
cilium  (ISO)
cytoplasm  (IBA,IDA,ISO)
cytoskeleton  (IEA,TAS)
cytosol  (ISO,TAS)
early endosome  (IEA,TAS)
focal adhesion  (IEA,TAS)
glutamatergic synapse  (ISO)
Golgi apparatus  (IEA,TAS)
late endosome  (IEA,TAS)
microtubule cytoskeleton  (ISO)
mitochondrion  (TAS)
nuclear envelope  (ISO)
nucleoplasm  (IDA,IEA,ISO)
nucleus  (IBA,ISO,TAS)
plasma membrane  (IDA)
protein-containing complex  (IDA)
pseudopodium  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway   (IEA)
aldosterone signaling pathway   (IEA)
Alzheimer's disease pathway  (IEA)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (IEA,ISO)
Chagas disease pathway  (IEA)
chemokine mediated signaling pathway  (IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway   (IEA)
endometrial cancer pathway  (IEA)
endothelin signaling pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis   (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA,ISO)
Fc epsilon receptor mediated signaling pathway  (IEA)
Fc gamma receptor mediated signaling pathway  (IEA)
fibroblast growth factor signaling pathway  (ISO)
glioma pathway  (IEA)
glutamate signaling pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (ISO)
hepatitis C pathway  (IEA)
influenza A pathway   (IEA)
insulin signaling pathway  (IEA)
interleukin-2 signaling pathway  (ISO)
Leishmaniasis pathway  (IEA)
long term depression  (IEA)
long term potentiation  (IEA)
melanoma pathway   (IEA)
mitogen activated protein kinase signaling pathway   (IEA)
mTOR signaling pathway  (IEA,ISO)
neurotrophic factor signaling pathway  (IEA)
NOD-like receptor signaling pathway   (IEA)
non-small cell lung carcinoma pathway   (IEA)
pancreatic cancer pathway  (IEA)
platelet-derived growth factor signaling pathway  (ISO)
prion disease pathway   (IEA)
prostate cancer pathway   (IEA)
renal cell carcinoma pathway  (IEA)
sphingosine 1-phosphate signaling pathway  (ISO)
syndecan signaling pathway  (ISO)
T cell receptor signaling pathway   (IEA)
the extracellular signal-regulated Raf/Mek/Erk signaling pathway  (IDA,IMP,ISO)
thyroid cancer pathway   (IEA)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway   (IEA)
Trail mediated signaling pathway  (ISO)
transforming growth factor-beta superfamily mediated signaling pathway  (IEA)
tuberculosis pathway   (IEA)
type 2 diabetes mellitus pathway  (IEA)
type II interferon signaling pathway  (ISO)
urinary bladder cancer pathway   (IEA)
vascular endothelial growth factor signaling pathway  (IEA,ISO)

References

References - curated
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3. Bradykinin reduces growth factor-induced glomerular ERK1/2 phosphorylation. Cellier E, etal., Am J Physiol Renal Physiol 2003 Feb;284(2):F282-92.
4. Anti-tumorigenic action of 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b)pyran: evidence for involvement of GPR30/EGFR signaling pathway. Chandra V, etal., Gynecol Oncol. 2013 May;129(2):433-42. doi: 10.1016/j.ygyno.2013.02.005. Epub 2013 Feb 8.
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6. Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades. Chen J, etal., Eur J Neurosci. 2009 Jan;29(2):287-306.
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9. SRC kinase and mitogen-activated protein kinases in the progression from normal to malignant endometrium. Desouki MM and Rowan BG, Clin Cancer Res. 2004 Jan 15;10(2):546-55.
10. Nanoproteomic analysis of extracellular receptor kinase-1/2 post-translational activation in microdissected human hyperplastic colon lesions. Drew DA, etal., Proteomics. 2013 May;13(9):1428-36. doi: 10.1002/pmic.201200430. Epub 2013 Apr 4.
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12. Expression and activity of mitogen activated protein kinases in human colorectal carcinoma. Eggstein S, etal., Gut. 1999 Jun;44(6):834-8.
13. Effect of suvorexant on morphine tolerance and dependence in mice: Role of NMDA, AMPA, ERK and CREB proteins. Esmaili-Shahzade-Ali-Akbari P, etal., Neurotoxicology. 2021 May;84:64-72. doi: 10.1016/j.neuro.2021.02.005. Epub 2021 Feb 18.
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20. Intranasal Lactoferrin Enhances a-Secretase-Dependent Amyloid Precursor Protein Processing via the ERK1/2-CREB and HIF-1a Pathways in an Alzheimer's Disease Mouse Model. Guo C, etal., Neuropsychopharmacology. 2017 Dec;42(13):2504-2515. doi: 10.1038/npp.2017.8. Epub 2017 Jan 12.
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33. ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas. Ku MC, etal., Mol Cancer Ther. 2016 Aug;15(8):1975-87. doi: 10.1158/1535-7163.MCT-15-0850. Epub 2016 Jun 2.
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36. Growth suppression of colorectal cancer by plant-derived multiple mAb CO17-1A × BR55 via inhibition of ERK1/2 phosphorylation. Kwak DH, etal., Int J Mol Sci. 2014 Nov 14;15(11):21105-19. doi: 10.3390/ijms151121105.
37. A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2. Kwon H, etal., J Cell Mol Med. 2011 Apr;15(4):888-908. doi: 10.1111/j.1582-4934.2010.01079.x.
38. Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. Li C, etal., J Clin Invest. 2014 May;124(5):2172-87. Epub 2014 Apr 1.
39. [Effects of hydrogen sulfide on myocardial fibrosis and MAPK1/3 and MMP-8 expression in diabetic rats]. Li F, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2015 Apr;35(4):549-52.
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PMID:28609839   PMID:28688765   PMID:28730748   PMID:28738742   PMID:28758954   PMID:28836382   PMID:28839270   PMID:28987634   PMID:29101749   PMID:29441602   PMID:29466698   PMID:29520716  
PMID:29592783   PMID:29742816   PMID:29845273   PMID:29901080   PMID:30138615   PMID:30430306   PMID:31032358   PMID:32105707   PMID:32782146   PMID:33107061   PMID:33881378   PMID:34204888  
PMID:34316004   PMID:35243702   PMID:36122168   PMID:36282438   PMID:36890454   PMID:37338759   PMID:38791516   PMID:39285628  


Genomics

Comparative Map Data
Mapk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,797,189 - 190,803,411 (+)NCBIGRCr8
mRatBN7.21181,366,646 - 181,372,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,366,637 - 181,372,863 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,717,952 - 189,724,168 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,904,026 - 196,910,242 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,571,369 - 189,577,596 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,192,773 - 198,198,975 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,192,773 - 198,198,975 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,172,641 - 205,178,843 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,935,044 - 185,941,245 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,084,924 - 186,091,127 (+)NCBI
Celera1179,022,318 - 179,028,386 (+)NCBICelera
Cytogenetic Map1q36NCBI
MAPK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,114,105 - 30,123,220 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,114,105 - 30,123,506 (-)EnsemblGRCh38hg38GRCh38
GRCh371630,125,426 - 30,134,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,032,927 - 30,042,131 (-)NCBINCBI36Build 36hg18NCBI36
Build 341630,032,927 - 30,042,039NCBI
Celera1672,661,419 - 72,670,625 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,786,557 - 27,795,763 (-)NCBIHuRef
CHM1_11631,341,181 - 31,350,385 (-)NCBICHM1_1
T2T-CHM13v2.01630,396,752 - 30,405,867 (-)NCBIT2T-CHM13v2.0
Mapk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,358,798 - 126,364,988 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,358,773 - 126,364,991 (+)EnsemblGRCm39 Ensembl
GRCm387126,759,626 - 126,765,816 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,759,601 - 126,765,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv377133,903,140 - 133,909,330 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,550,780 - 126,556,964 (+)NCBIMGSCv36mm8
Celera7126,607,166 - 126,613,154 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.25NCBI
Mapk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,869,668 - 6,879,152 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,870,699 - 6,876,836 (+)NCBIChiLan1.0ChiLan1.0
MAPK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21830,864,038 - 30,873,180 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11635,352,686 - 35,361,831 (+)NCBINHGRI_mPanPan1
PanPan1.11630,489,362 - 30,498,026 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,489,362 - 30,498,017 (-)Ensemblpanpan1.1panPan2
MAPK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,109,184 - 18,115,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,109,222 - 18,114,425 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,687,831 - 19,694,273 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,245,190 - 18,251,639 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,245,190 - 18,251,639 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,044,145 - 18,050,587 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,959,533 - 17,965,981 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,275,160 - 18,281,602 (-)NCBIUU_Cfam_GSD_1.0
Mapk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,287,605 - 124,292,797 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,384,804 - 12,392,180 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,342,670 - 12,390,650 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,291,445 - 18,299,567 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,291,444 - 18,299,410 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAPK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,536,471 - 26,545,666 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,536,532 - 26,546,461 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660682,993,354 - 3,002,555 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,152,039 - 13,159,113 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,150,824 - 13,158,327 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:73
Interacting mature miRNAs:97
Transcripts:ENSRNOT00000026627
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1182383862191260518Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1188241285197807511Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
Prkm3-rs1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,372,667 - 181,372,836 (+)MAPPERmRatBN7.2
Rnor_6.01198,198,785 - 198,198,953NCBIRnor6.0
Rnor_5.01205,178,653 - 205,178,821UniSTSRnor5.0
RGSC_v3.41185,941,056 - 185,941,224UniSTSRGSC3.4
Celera1179,028,196 - 179,028,364UniSTS
Cytogenetic Map1q36UniSTS
BI278071  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21181,372,449 - 181,372,636 (+)MAPPERmRatBN7.2
mRatBN7.21142,352,418 - 42,352,605 (+)MAPPERmRatBN7.2
Rnor_6.01144,459,798 - 44,459,984NCBIRnor6.0
Rnor_6.01198,198,567 - 198,198,753NCBIRnor6.0
Rnor_5.01147,652,898 - 47,653,084UniSTSRnor5.0
Rnor_5.01205,178,435 - 205,178,621UniSTSRnor5.0
RGSC_v3.41185,940,838 - 185,941,024UniSTSRGSC3.4
RGSC_v3.41143,172,337 - 43,172,523UniSTSRGSC3.4
Celera1142,150,435 - 42,150,621UniSTS
Celera1179,027,978 - 179,028,164UniSTS
Cytogenetic Map11q12UniSTS
Cytogenetic Map1q36UniSTS
Mapk3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21142,352,315 - 42,353,222 (+)MAPPERmRatBN7.2
Rnor_6.01144,459,695 - 44,460,601NCBIRnor6.0
Rnor_5.01147,652,795 - 47,653,701UniSTSRnor5.0
RGSC_v3.41143,172,234 - 43,173,140UniSTSRGSC3.4
Celera1142,150,332 - 42,151,238UniSTS
Cytogenetic Map11q12UniSTS
Cytogenetic Map1q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000087625   ⟹   ENSRNOP00000070784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,366,637 - 181,372,863 (+)Ensembl
Rnor_6.0 Ensembl1198,192,773 - 198,198,975 (+)Ensembl
RefSeq Acc Id: NM_017347   ⟹   NP_059043
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,797,194 - 190,803,411 (+)NCBI
mRatBN7.21181,366,646 - 181,372,863 (+)NCBI
Rnor_6.01198,192,773 - 198,198,975 (+)NCBI
Rnor_5.01205,172,641 - 205,178,843 (+)NCBI
RGSC_v3.41185,935,044 - 185,941,245 (+)RGD
Celera1179,022,318 - 179,028,386 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039088525   ⟹   XP_038944453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81190,797,189 - 190,803,410 (+)NCBI
mRatBN7.21181,366,650 - 181,372,862 (+)NCBI
RefSeq Acc Id: NP_059043   ⟸   NM_017347
- UniProtKB: Q62686 (UniProtKB/Swiss-Prot),   Q4PIY8 (UniProtKB/Swiss-Prot),   P21708 (UniProtKB/Swiss-Prot),   Q9JJ13 (UniProtKB/Swiss-Prot),   A0A8L2R3C3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070784   ⟸   ENSRNOT00000087625
RefSeq Acc Id: XP_038944453   ⟸   XM_039088525
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R3C3 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21708-F1-model_v2 AlphaFold P21708 1-380 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690409
Promoter ID:EPDNEW_R934
Type:multiple initiation site
Name:Mapk3_1
Description:mitogen activated protein kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01198,192,787 - 198,192,847EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3046 AgrOrtholog
BioCyc Gene G2FUF-57423 BioCyc
Ensembl Genes ENSRNOG00000053583 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055026224 UniProtKB/Swiss-Prot
  ENSRNOG00060030957 UniProtKB/Swiss-Prot
  ENSRNOG00065016730 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000087625.2 UniProtKB/TrEMBL
  ENSRNOT00055045334 UniProtKB/Swiss-Prot
  ENSRNOT00060053835 UniProtKB/Swiss-Prot
  ENSRNOT00065027942 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPK_ERK1/2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50689 UniProtKB/Swiss-Prot
NCBI Gene 50689 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MAPK3 RGD
PhenoGen Mapk3 PhenoGen
PRINTS ERK1ERK2MAPK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000053583 RatGTEx
  ENSRNOG00055026224 RatGTEx
  ENSRNOG00060030957 RatGTEx
  ENSRNOG00065016730 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2R3C3 ENTREZGENE, UniProtKB/TrEMBL
  MK03_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4PIY8 ENTREZGENE
  Q62686 ENTREZGENE
  Q9JJ13 ENTREZGENE
UniProt Secondary Q4PIY8 UniProtKB/Swiss-Prot
  Q62686 UniProtKB/Swiss-Prot
  Q9JJ13 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Mapk3  mitogen activated protein kinase 3    protein kinase, mitogen activated 3 (extracellular-signal-regulated kinase 1, ERK1)  Name updated 1299863 APPROVED
2002-06-10 Mapk3  mitogen activated protein kinase 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains protein product has protein kinase domain, tyrosine kinase catalytic domain, serine/threonine protein kinases catalytic domain 70317
gene_domains protein product has protein kinase domain, tyrosine kinase catalytic domain, serine/threonine protein kinases catalytic domain 70572
gene_expression enzyme specific activity decreases with age 70317
gene_expression expressed in all tissues 70317
gene_function phosphorylates protein serine/threonine residues 70317
gene_pathway 17 beta estradiol activates the extracellular regulated kinase/mitogen-activated protein kinase pathway at cellular level 70572
gene_process estrogen-mediated activation of the Erk/MAP kinase pathway immediately affects NMDA receptors and long term potentiation (LTP) 70572
gene_process functions in mitogenic signaling, activation is associated with cardiomyocyte hypertrophy 70317
gene_process mediates long-term memory and long-term potentiation (LTP) 631303
gene_process translocation to the nucleus is associated with the induction of late long-term potentiation (LTP); translocation activates transcription of immediate early genes (IEGs) after plasticity-inducing stimulation of neurons 631303
gene_regulation highly responsive to extracellular proliferative stimuli 70310
gene_regulation highly responsive to extracellular proliferative stimuli 70572
gene_regulation activated by estrogen in hippocampus, downregulation by ovariectomy 70572
gene_regulation activated by Map2k1, Mek2 phosphorylation 625493
gene_regulation induced by glutamate, acetylcholine, and BDNF in neurons 631303
gene_regulation activated by Endothelin-1 (ET-1) in glomerular mesangial cells 727457
gene_regulation 24R,25-dihydroxyvitamin D3 (24R,25-(OH)2D3) increases kinase activity via phospholipase D in resting zone (RC) cells 631303
gene_regulation ouabain induces activation in cardiac myocytes 631303
gene_regulation 1-alpha,25-dihydroxyvitamin D3 (1a,25-(OH)2D3) increases the kinase activity via phospholipase C in growth zone (GC) cells of growth plate chondrocytes 631303