TOLL-LIKE RECEPTOR SIGNALING PATHWAY (PW:0000814)

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Description

Toll-like receptors (TLR) represent a large and the better understood family of pattern recognition receptors (PRR) that respond to a diverse array of exogenous molecules and also several endogenous ones. PRRs 'sensing' of pathogen-associated molecular patterns (PAMPs) or endogenously derived damage-associated molecular patterns (DAMPs) is a first line of defense initiated by the innate immune system. Ligand-activated receptors impinge on intracellular signaling pathway to elicit the expression

Pathway Diagram:

Ariadne Genomics Inc. Cd14 ---- Lbp Lbp ---- LPS LPS Cd14 Lbp LPS ---- Ly96 Ly96 Traf6 ---- Ube2n Traf6 ---- Ube2v1 Irak1 ---- Traf6 Irak2 Irak4 ---> Irak1 Irak1 Irak4 ---- Myd88 Irak4 Myd88 Unc93b1 Myd88 ---- Tlr8 Unc93b1 ---> Tlr7 Myd88 ---- Tlr7 Myd88 ---- Tirap Myd88 ---- Tlr9 Traf6 TICAM1 ---- Traf6 Ripk1 --+> nuclear factor kappa B signaling pathway TICAM1 ---- Ticam2 Ticam2 Tradd Irak4 ---> Irak2 Ripk1 ---- Tradd Ripk1 Ripk1 ---- TICAM1 TICAM1 ---- Tlr3 TICAM1 ---- Traf3 Traf3 Tbk1 Tbk1 ---> Irf3 Tbk1 ---- Traf3 LPS ---- Tlr4 Tlr3 endocytosed_Tlr4 ---- Ticam2 flagellin ---- Tlr5 Tirap Tirap ---- Tlr6 Tirap ---- Tlr2 Tirap ---- Tlr1 Ly96 ---- Tlr4 Tlr1 ---- Tlr1, 2, 6 ligands Tlr1, 2, 6 ligands ---- Tlr2 Tlr1, 2, 6 ligands ---- Tlr6 Map3k7 --+> p38 MAPK signaling pathway Tlr4 ---> endocytosed_Tlr4 Double-stranded RNA ---- Tlr3 Map3k7 --+> c-Jun N-terminal kinases MAPK signaling pathway Map3k7 --+> nuclear factor kappa B signaling pathway Tlr7, 8, 9 ligands ---- Tlr8 Tlr7 ---- Tlr7, 8, 9 ligands Unc93b1 ---> Tlr8 Tlr8 Tlr7, 8, 9 ligands ---- Tlr9 Tlr7 Tlr9 Unc93b1 ---> Tlr9 Tlr4 Tirap ---- Tlr4 Tlr6 Tlr2 Tlr1 Tlr1 ---- Tlr2 Tlr2 ---- Tlr6 Myd88 ---- Tlr5 Tlr5 TICAM1 Ube2v1 Ube2n Traf6 --+> Map3k7 nuclear factor kappa B signaling pathway c-Jun N-terminal kinases MAPK signaling pathway p38 MAPK signaling pathway Tlr7, 8, 9 ligands Tlr1, 2, 6 ligands flagellin Double-stranded RNA Tab(s) Map3k7 Irf3 endocytosed_Tlr4
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Genes in Pathway:

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Toll-like receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6907045
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6907045
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6907045
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:6907045
RGD:7247704
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:6907045
G Cd80 Cd80 molecule JBrowse link 11 64,815,201 64,855,293 RGD:6907045
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:6907045
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6907045
G Ctsk cathepsin K JBrowse link 2 196,655,469 196,666,447 RGD:6907045
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6907045
G Cxcl11 C-X-C motif chemokine ligand 11 JBrowse link 14 17,195,395 17,198,170 RGD:6907045
G Cxcl9 C-X-C motif chemokine ligand 9 JBrowse link 14 17,228,832 17,233,743 RGD:6907045
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:6907045
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6907045
G Ifna1 interferon, alpha 1 JBrowse link 5 106,951,822 106,952,908 RGD:6907045
G Ifna11 interferon alpha family, gene 11 JBrowse link 5 107,504,741 107,505,783 RGD:6907045
G Ifna2 interferon alpha 2 JBrowse link 5 107,416,117 107,416,695 RGD:6907045
G Ifna4 interferon, alpha 4 JBrowse link 5 106,922,563 106,923,132 RGD:6907045
G Ifna5 interferon, alpha 5 JBrowse link 5 107,039,347 107,039,925 RGD:6907045
G Ifnar1 interferon alpha and beta receptor subunit 1 JBrowse link 11 31,640,407 31,666,839 RGD:6907045
G Ifnb1 interferon beta 1 JBrowse link 5 106,865,192 106,865,746 RGD:6907045
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon JBrowse link 13 48,031,325 48,056,394 RGD:6907045
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6907045
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:6907045
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6907045
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6907045
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6907045
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:5685014
RGD:6907045
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 4 145,594,575 145,651,066 RGD:5685014
G Irak4 interleukin-1 receptor-associated kinase 4 JBrowse link 7 135,803,723 135,831,006 RGD:5685014
RGD:6907045
G Irf3 interferon regulatory factor 3 JBrowse link 1 100,992,244 100,997,202 RGD:5685014
RGD:6907045
G Irf5 interferon regulatory factor 5 JBrowse link 4 56,804,477 56,816,271 RGD:6907045
G Irf7 interferon regulatory factor 7 JBrowse link 1 214,249,388 214,252,909 RGD:6907045
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6907045
G Lbp lipopolysaccharide binding protein JBrowse link 3 154,786,232 154,812,910 RGD:6907045
RGD:7247704
G LOC100911527 interferon alpha-12-like JBrowse link 5 87,328,395 87,328,946 RGD:6907045
G Ly96 lymphocyte antigen 96 JBrowse link 5 1,972,212 1,989,448 RGD:5685019
RGD:7247704
RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:6907045
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:6907045
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6907045
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:6907045
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:5685014
RGD:6907045
G Map3k8 mitogen-activated protein kinase kinase kinase 8 JBrowse link 17 56,109,403 56,129,925 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:6907045
G Mapk12 mitogen-activated protein kinase 12 JBrowse link 7 130,109,214 130,120,918 RGD:6907045
G Mapk13 mitogen activated protein kinase 13 JBrowse link 20 6,018,374 6,027,467 RGD:6907045
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Myd88 MYD88, innate immune signal transduction adaptor JBrowse link 8 128,022,512 128,027,462 RGD:5685014
RGD:6907045
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6907045
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6907045
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6907045
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:5685014
RGD:6907045
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:6907045
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6907045
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:5685016
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:5685016
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 JBrowse link X 54,035,958 54,090,282 RGD:5685016
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:5685014
RGD:6907045
G Ticam2 toll-like receptor adaptor molecule 2 JBrowse link 18 40,555,106 40,572,569 RGD:5685014
RGD:6907045
G Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:5685014
RGD:6907045
G Tlr1 toll-like receptor 1 JBrowse link 14 45,062,662 45,065,014 RGD:1643119
RGD:5685014
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1643119
RGD:6907045
RGD:5685014
RGD:5684896
G Tlr3 toll-like receptor 3 JBrowse link 16 50,016,466 50,031,011 RGD:1643119
RGD:6907045
RGD:5685014
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1643119
RGD:7247704
RGD:6907045
RGD:5685014
G Tlr5 toll-like receptor 5 JBrowse link 13 101,364,784 101,385,764 RGD:1643119
RGD:6907045
RGD:5685014
G Tlr6 toll-like receptor 6 JBrowse link 14 45,024,351 45,041,188 RGD:1643119
RGD:6907045
RGD:5685014
RGD:5684896
G Tlr7 toll-like receptor 7 JBrowse link X 28,486,836 28,513,004 RGD:1643119
RGD:6907045
RGD:5685014
G Tlr8 toll-like receptor 8 JBrowse link X 28,539,158 28,562,803 RGD:1643119
RGD:6907045
RGD:5685014
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1643119
RGD:6907045
RGD:5685014
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6907045
G Tollip toll interacting protein JBrowse link 1 214,823,993 214,844,861 RGD:6907045
G Tradd TNFRSF1A-associated via death domain JBrowse link 19 37,214,461 37,221,099 RGD:5685014
G Traf3 Tnf receptor-associated factor 3 JBrowse link 6 135,610,698 135,720,247 RGD:5685014
RGD:6907045
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:5685014
RGD:6907045
G Ube2n ubiquitin-conjugating enzyme E2N JBrowse link 7 36,610,147 36,640,190 RGD:5685014
G Ube2v1 ubiquitin conjugating enzyme E2 V1 JBrowse link 3 164,343,833 164,366,684 RGD:5685014
G Unc93b1 unc-93 homolog B1, TLR signaling regulator JBrowse link 1 219,172,987 219,183,941 RGD:5685014

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculeTlr1, 2, 6 ligands
Small MoleculeTlr7, 8, 9 ligands
Functional ClassTab(s)Map3k7 binding proteins
Pathwaynuclear factor kappa B signaling pathwaynf-kappaB signaling plays essential roles in the proper functioning of the immune system
Pathwayc-Jun N-terminal kinases MAPK signaling pathwayone of the two stress activated MAPK cascades that responds to inflammatory cytokines and various stresses
Pathwayp38 MAPK signaling pathwayone of the two stress activated MAPK cascades that responds to inflammatory cytokines and various stresses

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Toll-like receptor signaling pathway
Disease TermsGene Symbols
abdominal aortic aneurysmMapk8
abdominal obesity-metabolic syndrome 1Fadd
Aberrant Crypt FociFos , Mapk1 , Mapk3
Abortion, SpontaneousCcl5 , Cxcl10 , Il12b , Il1b , Il6
Acanthamoeba KeratitisTlr4
AchlorhydriaTlr9
acneTlr2 , Tlr4 , Tnf
Acne ConglobataTlr4
acquired immunodeficiency syndromeCcl3 , Tlr3 , Tnf
Acute Coronary SyndromeCd40 , Il6 , Tlr4 , Tnf
acute kidney failureCcl3 , Ccl5 , Il1b , Il6 , Nfkb1 , Spp1 , Tlr2 , Tlr4 , Tlr9 , Tnf
Acute Liver FailureCd14 , Il6 , Mapk8 , Tlr4 , Tnf
Acute Lung InjuryCasp8 , Fadd , Il1b , Il6 , Tlr4 , Tnf
acute myeloid leukemiaCd86 , Fadd , Il6
acute myocarditisCd40
Acute Necrotizing PancreatitisIl1b , Il6 , Nfkbia , Rela , Tlr2 , Tlr4 , Tlr9
acute promyelocytic leukemiaAkt1
Acute Tubulointerstitial NephritisTlr2 , Tlr4
Acute-On-Chronic Liver FailureTlr4
Acute-Phase ReactionIl6
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaCasp8 , Il1b , Nfkb1 , Pik3ca , Spp1 , Tnf
adenoid cystic carcinomaMap2k2 , Pik3ca
adrenal carcinomaPik3ca
adrenocortical carcinomaPik3ca
adult respiratory distress syndromeCxcl10 , Il1b , Tlr3 , Tlr5 , Tlr9 , Tnf
adult T-cell leukemiaCd80 , Cd86 , Il6
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
age related macular degeneration 10Tlr4
Aggressive FibromatosisTnf
agranulocytosisIl1b
AIDS Dementia ComplexIl1b
AlbuminuriaIl1b , Il6 , Spp1 , Tnf
Alcohol-Related DisordersCasp8
alcoholic hepatitisCcl5 , Tnf
alcoholic liver cirrhosisIl6 , Rela , Tlr9 , Tnf
Alcoholic Liver DiseasesIl1b , Spp1
allergic bronchopulmonary aspergillosisTlr9 , Tnf
allergic conjunctivitisCcl5 , Il1b , Tlr2 , Tlr4 , Tlr9
allergic contact dermatitisCasp8 , Ccl5 , Spp1 , Tlr4 , Tlr7 , Tnf
allergic hypersensitivity diseaseCcl3 , Cd14 , Cxcl9 , Il1b , Il6 , Map2k6 , Spp1 , Tnf
allergic rhinitisCd40 , Il1b , Tlr2 , Tlr4 , Tlr9
alopecia areataCxcl10 , Cxcl9
Alport syndromeIl1b
Alveolar Bone LossTnf
Alzheimer's diseaseAkt1 , Casp8 , Ccl5 , Cd40 , Fadd , Ikbkb , Il1b , Il6 , Mapk1 , Mapk10 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Pik3r1 , Tlr4 , Tnf
amelanotic melanomaIfnb1
amnestic disorderIl6
amphetamine abuseAkt1 , Fos , Rela
amyloidosisTnf
amyotrophic lateral sclerosisAkt1 , Mapk14 , Tnf
amyotrophic lateral sclerosis type 1Fos , Tnf
anemiaIl1b , Il6 , Tnf
AneurysmSpp1
Angina PectorisSpp1
Angina, StableTlr4 , Tnf
angiomyolipomaStat1
angiosarcomaJun
Anhidrotic Ectodermal Dysplasia with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Animal Disease ModelsAkt1 , Fos , Il1b , Irak4 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Tnf
Animal HelminthiasisCd40
Animal Mammary NeoplasmsCd40 , Map2k6 , Pik3r1
Animal ToxoplasmosisCcl5
ankylosing spondylitisIl12b , Il6 , Irak1 , Tlr4 , Tlr5
anogenital venereal wartIl12b
AnorexiaIl1b , Tnf
anterior uveitisCcl3 , Tlr2 , Tlr4 , Tnf
anthracosisIl1b , Tnf
anti-basement membrane glomerulonephritisCcl5 , Cd40 , Cd80 , Il1b , Mapk14 , Mapk8 , Spp1 , Tnf
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisTlr2 , Tnf
anus benign neoplasmIfnb1
anxiety disorderFos , Tnf
aortic valve disease 1Il6
aortic valve stenosisTnf
Aortic Valve, Calcification ofAkt1
aplastic anemiaCd86 , Tnf
Arsenic PoisoningIl1b , Tnf
arteriosclerosisCcl5 , Il1b , Mapk9 , Rela , Tlr4
arteriovenous malformations of the brainIl6
arthritisCd40 , Tlr4
asbestosisSpp1 , Tnf
Ascorbic Acid DeficiencyIl6
aseptic meningitisIl6
aspergillosisTlr1 , Tlr2 , Tlr6
AsphyxiaJun
aspiration pneumoniaTnf
asthmaCcl5 , Cd14 , Cd40 , Cd80 , Cd86 , Chuk , Cxcl10 , Cxcl9 , Il12a , Il12b , Il1b , Il6 , Irf3 , Tlr1 , Tlr2 , Tlr3 , Tlr4 , Tlr6 , Tlr9 , Tnf
astroblastomaPik3r1
astrocytomaAkt1 , Akt2 , Akt3 , Map2k3
ataxia telangiectasiaIl6
ataxia with oculomotor apraxia type 3Pik3r5
atherosclerosisAkt1 , Ccl3 , Cd40 , Il1b , Il6 , Tlr2 , Tlr4 , Tnf
atopic dermatitisCasp8 , Ccl5 , Cd40 , Cxcl10 , Il1b , Il6 , Mapk8 , Nfkbia , Tlr2 , Tlr4 , Tnf
atrial fibrillationCd40 , Tlr2 , Tnf
atrophic gastritisIl1b
AtrophyMapk3
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
autism spectrum disorderMapk11 , Mapk12 , Mapk3 , Tlr3
autistic disorderIl6 , Mapk1 , Tnf
Autoimmune DiseasesCasp8 , Il6
autoimmune hepatitisCcl5 , Il6
autoimmune lymphoproliferative syndromeCasp8
autoimmune lymphoproliferative syndrome type 2BCasp8
autoimmune thrombocytopenic purpuraCd40 , Cd86
autoimmune thyroiditisIl6 , Tlr3 , Tnf
autosomal dominant mental retardation 48Rac1
autosomal dominant polycystic kidney diseaseCd14 , Fos , Spp1
autosomal recessive polycystic kidney diseaseAkt1 , Cd14 , Pik3ca
B-Cell Chronic Lymphocytic LeukemiaCd40 , Cd86 , Il1b , Il6 , Myd88 , Tnf
B-cell lymphomaCd40
BacteremiaTirap , Tlr4
Bacterial Eye InfectionsTlr2
Bacterial Infections and MycosesIrak4
bacterial infectious diseaseCasp8
Bacterial KeratitisLy96 , Myd88 , Tlr2 , Tlr4 , Tlr5
bacterial pneumoniaCd14 , Cd40 , Cd80 , Chuk , Cxcl10 , Cxcl11 , Cxcl9 , Ifnar1 , Il1b , Irf3 , Tlr2 , Tlr4 , Tlr5 , Tlr6 , Tlr9 , Tnf
Bannayan-Riley-Ruvalcaba syndromePik3ca
Bardet-Biedl syndromeAkt3
Barrett's esophagusRela
basal cell carcinomaIl6 , Pik3ca
BCG and Salmonella Infection, DisseminatedIl12b
Behcet's diseaseIkbkg , Il1b , Il6 , Tlr2 , Tlr3 , Tlr4 , Tnf
berylliosisIl6 , Tnf
beta thalassemiaIl6 , Tnf
Bile Duct NeoplasmsIl6
biliary atresiaCd14 , Spp1
biliary tract benign neoplasmIl6
bilirubin metabolic disorderTnf
bipolar disorderAkt1
bladder urothelial carcinomaAkt1 , Map2k1 , Pik3ca
Bloch-Sulzberger syndromeIkbkg
bone development diseaseChuk
boutonneuse feverCxcl10 , Cxcl9
Brain AbscessTlr2
Brain ConcussionIl6
Brain ContusionCasp8
Brain DeathMap2k4 , Map2k6
brain diseaseIfnb1
brain edemaTnf
brain gliomaFadd
brain infarctionIl1b
Brain InjuriesAkt1 , Casp8 , Cd14 , Cd40 , Cxcl10 , Fos , Il1b , Il6 , Jun , Rela , Stat1 , Ticam2 , Tlr1 , Tlr2 , Tlr4 , Tlr9 , Tnf
brain ischemiaAkt1 , Ccl3 , Cxcl10 , Il1b , Il6 , Irak1 , Irak4 , Jun , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Nfkb1 , Nfkbia , Rela , Tlr4 , Tnf
Brain NeoplasmsPik3ca , Pik3r1 , Rela , Spp1
breast adenocarcinomaAkt1 , Pik3ca
breast cancerAkt1 , Casp8 , Il1b , Nfkb1 , Pik3ca , Stat1
Breast Cancer, FamilialPik3ca , Pik3r3
Breast NeoplasmsAkt1 , Akt2 , Casp8 , Ccl5 , Cd40 , Cxcl9 , Fos , Ifnb1 , Ikbkb , Il1b , Il6 , Jun , Map2k1 , Map2k2 , Map2k3 , Map2k4 , Map2k7 , Mapk1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Spp1 , Stat1 , Tlr2 , Tlr4 , Tlr9 , Tnf
Bronchial HyperreactivityCd14 , Il1b , Tlr4 , Tnf
bronchiectasisIl1b , Stat1 , Tnf
bronchiolitisCd40 , Cd86 , Il1b
bronchiolitis obliteransCcl5 , Cd86 , Cxcl10 , Cxcl11 , Cxcl9 , Il6 , Tlr9
bronchopneumoniaCcl5
Bronchopulmonary DysplasiaCasp8 , Il1b , Tnf
Brugada syndromeMyd88
Bruton-type agammaglobulinemiaPik3r1
Burkitt lymphomaCd40 , Pik3r1
BurnsCd14 , Cd86 , Il1b , Il6 , Lbp , Tnf
Burns, ChemicalIl1b , Il6
CachexiaIl1b , Il6 , Tnf
Cadmium PoisoningIl6
calcinosisIl1b , Spp1
cancerPik3ca , Pik3r1
Candidiasis, Familial, 6Stat1
cannabis abuseAkt1
capillary hemangiomaAkt3
Carbon Tetrachloride PoisoningFadd
carcinomaLy96 , Pik3r1 , Tlr4
cardiac arrestAkt1 , Ccl5 , Tnf
Cardiac ArrhythmiasMap2k4
Cardiac FibrosisNfkbia
cardiofaciocutaneous syndromeMap2k1 , Map2k2
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Il1b , Il6 , Map2k6 , Mapk1 , Mapk8 , Rac1 , Rela , Spp1 , Tnf
cardiomyopathyAkt1 , Il1b , Il6 , Irak1 , Mapk1 , Mapk11 , Mapk14 , Mapk3 , Tlr2 , Tnf
CardiotoxicityRac1
Cardiovascular AbnormalitiesMap2k1
cardiovascular system diseaseTlr9
Cardiovirus InfectionsIfnar1 , Tnf
carotid artery diseaseCd14 , Tlr4
carotid stenosisTlr2 , Tlr4
Carrington SyndromeCxcl10 , Cxcl9
Castleman diseaseIl6
cataractMap2k1
CD40 deficiencyCd40
celiac diseaseCd14 , Cd80 , Il6
Cell Transformation, NeoplasticFos , Il6 , Jun , Mapk8 , Myd88 , Nfkb1 , Rac1 , Rela
central nervous system diseaseIl6
Cerebral HemorrhageCasp8 , Cd14 , Nfkb1 , Nfkbia , Rela , Spp1
cerebral infarctionTnf
cervix uteri carcinoma in situRela , Tlr9
Chagas diseaseCcl3 , Ccl5
Charcot-Marie-Tooth disease axonal type 2KLy96
Charcot-Marie-Tooth disease dominant intermediate CPik3r3
Chemical and Drug Induced Liver InjuryCasp8 , Cxcl10 , Fadd , Il1b , Il6 , Irak1 , Lbp , Spp1 , Tnf , Unc93b1
childhood pilocytic astrocytomaMapk1
Childhood SchizophreniaRela
chlamydiaCd40 , Tnf
cholangiocarcinomaIl6
cholestasisCd14 , Il6 , Ly96 , Mapk13 , Mapk14 , Rela , Tlr2 , Tnf
cholesteatomaIl1b , Tlr2 , Tlr4
cholesteatoma of middle earIl6 , Rela , Tlr2 , Tlr4 , Tnf
chorioamnionitisIl6 , Tnf
Choroidal NeovascularizationIkbkb , Tlr2
chromosome 17q12 deletion syndromeCcl3
Chronic Allograft DysfunctionCd40 , Tnf
Chronic Allograft NephropathyCcl3
Chronic Cerebral HypoperfusionMapk14
chronic granulomatous diseaseTlr5 , Tlr9
chronic inflammatory demyelinating polyradiculoneuropathyCcl5
Chronic Intermittent HypoxiaFadd
chronic kidney diseaseIl1b , Tlr9
chronic lymphocytic leukemiaCd86 , Myd88
chronic mucocutaneous candidiasisStat1
chronic myeloid leukemiaAkt1 , Cd40 , Il1b , Mapk14
chronic obstructive pulmonary diseaseCasp8 , Ccl5 , Cd40 , Cd80 , Cd86 , Cxcl10 , Cxcl11 , Cxcl9 , Il12b , Il1b , Il6 , Map2k4 , Mapk8 , Tlr4 , Tnf
Chronic PainTlr2 , Tlr4
Chronic PeriodontitisTlr2 , Tlr3 , Tlr4 , Tlr9
chronic progressive external ophthalmoplegiaIl1b
cicatricial pemphigoidTnf
cleft palateChuk
CLOVES syndromePik3ca
Cocaine-Related DisordersFos , Mapk1 , Mapk3
cochlear diseaseIl1b , Il6 , Tnf
cocoon syndromeChuk
cognitive disorderIrak1 , Mapk14
Cognitive DysfunctionIl1b , Stat1
colitisCd40 , Chuk , Ikbkb , Il1b , Il6 , Rela , Tlr3 , Tlr4 , Tnf
colon adenocarcinomaMapk1 , Mapk3 , Pik3r3 , Rac1
colon adenomaRac1
colon cancerAkt1 , Pik3ca
colon carcinomaAkt1 , Pik3ca
Colonic NeoplasmsAkt2 , Akt3 , Ccl3 , Cxcl10 , Fos , Ikbkb , Il1b , Jun , Map2k3 , Map2k6 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3r1 , Pik3r2 , Pik3r5 , Rela , Tnf
colorectal adenocarcinomaFos , Jun , Mapk1 , Mapk3 , Mapk8
colorectal adenomaFos , Jun , Mapk8
colorectal cancerAkt1 , Pik3ca , Rac1
Colorectal NeoplasmsAkt1 , Akt2 , Casp8 , Fos , Ly96 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Tlr2 , Tlr4 , Tnf
Combined Oxidative Phosphorylation Deficiency 11Ripk1
common coldCxcl10 , Il1b
common variable immunodeficiencyNfkb1
Common Variable Immunodeficiency 12Nfkb1
complex cortical dysplasia with other brain malformationsAkt3 , Pik3ca
congenital diaphragmatic herniaTnf
Congenital Heart Defects, Multiple Types, 2Tab2
Congenital Limb DeformitiesChuk
congestive heart failureFos , Il1b , Il6 , Map2k7 , Rac1 , Tnf
conjunctival diseaseIl6
contact dermatitisCasp8 , Cd86 , Tlr4 , Tlr8
Contrast-Induced NephropathyIl1b , Mapk8
Cor pulmonaleTnf
corneal diseaseCd86
corneal ulcerIl6 , Tnf
coronary artery diseaseAkt1 , Cd14 , Il1b , Il6 , Irak1 , Spp1 , Tlr4 , Tnf , Traf6
Coronary DiseaseCd14 , Il1b
coronary restenosisCxcl10 , Mapk1 , Spp1 , Tnf
Coronavirus InfectionsIl6
coronin-1A deficiencyMapk3
Costello syndromeMap2k1 , Map2k2
CoughTlr2 , Tnf
Cowden diseaseAkt1 , Pik3ca
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromePik3ca
Coxsackievirus InfectionsIl6 , Tnf
Craniofacial AbnormalitiesFadd
crescentic glomerulonephritisCcl3 , Cd40 , Il1b , Tlr9
Crohn's diseaseCd40 , Il12b , Il6 , Tlr4 , Tlr9 , Tnf
cryoglobulinemiaCd86 , Tnf
cryptococcosisCd40 , Cd86
cryptorchidismNfkbia , Rela
Currarino TriadPik3ca
cutaneous leishmaniasisIl1b , Tlr2 , Tlr4 , Tlr9 , Tnf
cutaneous lupus erythematosusCd40
cystic fibrosisCd14 , Cxcl9 , Il1b , Il6 , Tlr4 , Tlr5 , Tlr9 , Tnf
cystitisIl1b , Rela , Tlr5 , Tnf
Cytomegalovirus InfectionsCcl3 , Ccl5 , Stat1 , Tnf
cytomegalovirus retinitisTnf
Delayed HypersensitivityCd40
demyelinating diseaseCd80 , Mapk1 , Tnf
Dental Pulp ExposureCd86
dermatitisIkbkb , Tnf
dermatitis herpetiformisTnf
dermatomyositisCd40 , Il1b , Tlr2 , Tlr4 , Tlr9 , Tnf
Developmental DisabilitiesAkt3 , Pik3r2
diabetes mellitusCcl5 , Il6 , Rac1 , Tlr4
Diabetes Mellitus, Experimental Akt1 , Casp8 , Cd80 , Cd86 , Cxcl10 , Ifnar1 , Ikbkb , Il1b , Il6 , Map2k3 , Map2k6 , Mapk1 , Mapk3 , Nfkbia , Pik3r1 , Rela , Spp1 , Stat1 , Tlr2 , Tlr4 , Tnf
diabetic angiopathyRela , Tnf
Diabetic CardiomyopathiesCasp8 , Mapk1 , Mapk3 , Spp1 , Tnf
Diabetic EmbryopathyFadd
Diabetic FootTlr4
Diabetic NephropathiesCasp8 , Ccl5 , Cxcl10 , Il1b , Il6 , Mapk1 , Mapk14 , Rela , Spp1 , Tlr2 , Tlr4 , Tnf
diabetic neuropathyCcl5 , Il1b , Mapk14 , Tlr4 , Tnf
diabetic retinopathyCcl5 , Cxcl10 , Il1b , Il6 , Tlr4 , Tnf
Diaphragmatic HerniaIl6 , Tnf
diarrheaCd14
diffuse large B-cell lymphomaCd40 , Myd88 , Nfkbia , Pik3ca , Pik3cb , Pik3cd
diffuse sclerodermaIl6 , Tlr2
dilated cardiomyopathyCasp8 , Cd40 , Rac1 , Tnf
dilated cardiomyopathy 1HTnf
Discoid Lupus ErythematosusCd40
disease by infectious agentStat1 , Tnf
disease of cellular proliferationIl1b , Map2k1 , Pik3ca , Pik3r1 , Spp1
Disease ProgressionPik3ca , Stat1
disseminated intravascular coagulationIl6 , Tnf
drug allergyTnf
Drug Hypersensitivity SyndromeIl1b
Drug-Induced AgranulocytosisIl1b
Drug-Induced DyskinesiaRela
Drug-Induced Immune ThrombocytopeniaIl1b
Drug-Related Side Effects and Adverse ReactionsSpp1 , Tlr1 , Tlr2
dry eye syndromeIl1b , Il6 , Tlr2 , Tlr3 , Tlr4 , Tnf
ductal carcinoma in situRela
DyslipidemiasTlr2
Eales DiseaseIl1b , Il6 , Tnf
eclampsiaIl6
Ectodermal Dysplasia, Anhidrotic, with T-Cell Immunodeficiency, Autosomal DominantNfkbia
EczemaCd14 , Cd80
EdemaCasp8 , Il1b , Il6 , Map2k6 , Tnf
Ehrlich tumor carcinomaCd40
Embryo LossUbe2n
EmphysemaTnf
encephalitisCxcl10 , Il1b , Nfkbia , Rela , Tnf
encephalomyelitisSpp1 , Tnf
ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), 8Tbk1
Encephalopathy, Neonatal Severe, due to Mecp2 MutationsIkbkg , Irak1
end stage renal failureCcl3 , Ccl5 , Cd40 , Il1b , Il6 , Nfkb1 , Rela , Tlr2 , Tlr4 , Tnf
endometrial adenocarcinomaMapk1 , Mapk3 , Pik3r1
endometrial cancerPik3cb , Pik3r1
endometrial carcinomaMapk1 , Mapk3 , Pik3ca , Pik3r1
Endometrial NeoplasmsAkt2 , Jun , Mapk3 , Pik3ca , Pik3cb , Pik3cd
Endometrioid CarcinomasAkt1 , Mapk1 , Mapk3 , Pik3r2 , Spp1
endometriosisCcl5 , Fos , Nfkbia , Tnf
endophthalmitisIl1b , Tlr2 , Tnf
EndotoxemiaCcl5 , Cd14 , Cd40 , Il1b , Il6 , Lbp , Mapk14 , Tlr2 , Tlr4 , Tnf
Endotoxin HyporesponsivenessTlr4
EntamoebiasisIl1b , Il6 , Tlr4
EnterocolitisIl1b
EosinophiliaMyd88 , Tlr2 , Tlr4
EpendymomaTraf3
epidermal nevusPik3ca
epididymitisIl1b , Il6 , Tnf
epilepsyAkt1 , Fos , Il1b , Il6 , Rela , Tnf
erythema multiformeCd40
Erythema NodosumTnf
esophageal carcinomaPik3ca
Esophageal NeoplasmsCasp8
esophagitisTnf
esophagus adenocarcinomaPik3ca , Tlr4
eumycotic mycetomaTlr2 , Tlr4
Exercise-Induced AsthmaCcl5
exfoliation syndromeTlr4
Experimental Allergic AsthmaCd86
Experimental ArthritisAkt1 , Ccl3 , Ccl5 , Cd40 , Cd80 , Ctsk , Ikbkb , Ikbkg , Il1b , Il6 , Myd88 , Pik3cd , Stat1 , Tlr2 , Tlr3 , Tnf
Experimental Autoimmune EncephalomyelitisCasp8 , Ccl3 , Ccl5 , Cd80 , Cd86 , Il12a , Il12b , Il6 , Stat1 , Tlr2 , Tlr4 , Tnf
Experimental Autoimmune Myasthenia GravisCxcl10 , Cxcl9
Experimental Autoimmune MyocarditisCasp8 , Cd40 , Il6
Experimental Autoimmune NeuritisCd14 , Cd40 , Il1b , Spp1 , Tlr2 , Tlr4 , Tlr9 , Tnf
Experimental Autoimmune UveitisTlr4
Experimental ColitisIl6 , Mapk1 , Mapk3 , Nfkbia , Tnf
Experimental Liver CirrhosisCcl5 , Cd86 , Cxcl10 , Cxcl9 , Fos , Il1b , Il6 , Lbp , Ly96 , Map3k8 , Mapk1 , Mapk3 , Nfkbia , Rela , Spp1 , Tlr2 , Tlr4 , Tnf , Unc93b1
Experimental Liver NeoplasmsCxcl9 , Il6 , Map2k1 , Mapk1 , Mapk3 , Spp1 , Tnf
Experimental MelanomaIfnb1 , Ikbkb , Il1b
Experimental NeoplasmsIfnb1 , Il12a , Il12b , Rela , Spp1 , Tnf
Experimental PancreatitisIkbkg
extrahepatic cholestasisFos , Il1b , Il6 , Jun , Map3k7 , Mapk1 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Myd88 , Rela , Tlr4 , Tnf
extrinsic allergic alveolitisCcl5 , Cd86 , Cxcl10 , Cxcl11 , Cxcl9 , Il1b , Tlr6 , Tnf
Eye BurnsIl1b
eye diseaseTlr2 , Tlr3 , Tlr4 , Tnf
Facial AsymmetryPik3ca
Failure to ThriveStat1
familial adenomatous polyposisAkt1
familial Mediterranean feverIl1b , Il6 , Tlr4
familial partial lipodystrophyAkt2
Familial Prostate CancerCasp8 , Map2k1
Fanconi anemiaTnf
farmer's lungIl12b , Tnf
fatty liver diseaseIkbkg , Il1b , Il6 , Mapk8 , Nfkb1 , Rela , Tlr4 , Tnf
favismIkbkg
Female InfertilityMapk1 , Mapk3
Femoral FracturesIl6
Fetal DiseasesChuk
Fetal Inflammatory Response SyndromeIl6
FeverCcl5 , Il1b , Il6 , Tlr2 , Tnf
FibrosisAkt1 , Il1b , Map2k7 , Spp1 , Tlr4 , Tnf
Fibrous Dysplasia of BoneFos
focal segmental glomerulosclerosisCcl3 , Il1b , Spp1 , Tnf
follicular lymphomaCd40 , Myd88
Foot InjuriesIl6
Foot UlcerCxcl10
Foreign-Body ReactionSpp1
Forney Robinson Pascoe SyndromeMap3k7
Frontometaphyseal DysplasiaMap3k7
Frontometaphyseal Dysplasia 2Map3k7
FTDALS4Tbk1
Fungal Eye InfectionsTlr2 , Tlr4
Fungal KeratitisTlr4
Fungal Lung DiseasesTnf
gallbladder carcinomaPik3ca
Gallbladder NeoplasmsIl1b
gastric adenocarcinomaAkt1 , Map2k1 , Map2k2 , Pik3ca
gastric ulcerIl1b , Mapk1 , Mapk3 , Tnf
gastritisNfkbia , Tnf
Gastro-Enteropancreatic Neuroendocrine TumorCd86
gastroesophageal reflux diseaseTlr2
Gastrointestinal NeoplasmsPik3ca
Gaucher's diseaseTnf
Generalized EpilepsyMapk10
genetic diseaseAkt2 , Akt3 , Ctsk , Ikbkg , Map2k1 , Mapk1 , Pik3ca , Pik3r1 , Pik3r2 , Stat1
Genetic Predisposition to DiseaseIl1b
genital herpesCcl5
gestational diabetesIl6
gingivitisIl6
glaucomaTnf
Glaucoma 1, Open Angle, PTbk1
glioblastoma multiformeAkt1 , Akt3 , Ctsk , Il1b , Map2k2 , Map2k3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1
GliosisMapk1 , Mapk3
glomerulonephritisCcl3 , Ccl5 , Fos , Il1b , Il6 , Mapk1 , Spp1 , Tlr2 , Tlr4 , Tnf
glomerulosclerosisIl1b , Spp1
glucose intoleranceCcl5
glucosephosphate dehydrogenase deficiencyIkbkg , Il6
goutCd14 , Il1b
Graft vs Host DiseaseCd40 , Cxcl10 , Cxcl11 , Cxcl9
Gram-Negative Bacterial InfectionsIl1b
Gram-Positive Bacterial InfectionsTlr2
Granuloma, Foreign-BodyTlr9
Granuloma, Respiratory TractCxcl10 , Cxcl9 , Tlr3 , Tlr9
Graves OphthalmopathyTnf
Graves' diseaseCd40 , Il1b , Il6 , Tnf
Growth DisordersPik3ca
Guillain-Barre syndromeCd86
hairy cell leukemiaMap2k1
Hashimoto DiseaseCd40 , Il6
Head and Neck NeoplasmsMapk1 , Mapk3 , Pik3ca
head and neck squamous cell carcinomaAkt1 , Map2k1 , Map2k2 , Mapk1 , Pik3ca , Rac1
HeadacheIl6
Hearing LossStat1 , Tlr2 , Tlr4 , Tlr9 , Tnf
Hearing Loss, Noise-InducedIl6 , Tnf
Hearing Loss, SuddenIl6 , Tnf
heart diseaseCasp8 , Mapk14 , Spp1
Heart InjuriesIl1b
heart valve diseaseIl1b , Spp1
Heat Stress DisordersIl6
Heat StrokeFos , Il1b , Il6 , Jun , Nfkb1 , Rela , Tnf
hemarthrosisIl6
HematuriaFos
HemimegalencephalyPik3ca
hemochromatosisTnf
hemolytic-uremic syndromeCcl3 , Fos , Il1b , Il6 , Tnf
HemorrhageFos
Henoch-Schoenlein purpuraCd86
hepatic encephalopathyTnf
Hepatic InsufficiencyMapk14 , Rela
hepatitisSpp1
hepatitis BIfnb1
hepatitis CIfnar1 , Il1b
Hepatitis C, ChronicSpp1
hepatocellular carcinomaAkt1 , Akt2 , Casp8 , Ccl3 , Fos , Il1b , Il6 , Jun , Nfkbia , Pik3ca , Rac1 , Spp1 , Stat1 , Tlr4 , Tnf
HepatomegalyMapk14 , Rela
hepatorenal syndromeTlr4 , Tnf
hereditary hemorrhagic telangiectasiaTnf
Hereditary Neoplastic SyndromesCd14 , Pik3ca , Ticam2
Hermansky-Pudlak syndromeCcl5
Herpes Simplex EncephalitisIrf3 , Tlr2 , Tlr3 , Tlr4 , Tlr9 , Traf3 , Unc93b1
Herpes Simplex Encephalitis 1Tlr3 , Unc93b1
Herpes Simplex Encephalitis 3Traf3
Herpes Simplex Encephalitis 7Irf3
herpes simplex virus keratitisIl1b , Tlr2 , Tlr4 , Tlr9 , Tnf
herpes zosterTnf
Herpesviridae InfectionsCcl5
hidradenitis suppurativaTnf
High-Frequency Hearing LossTnf
Hirschsprung's diseaseCd14
HIV Wasting SyndromeIl1b , Il6 , Tnf
Hodgkin's lymphomaIl6 , Jun , Nfkbia
human immunodeficiency virus infectious diseaseCcl3 , Ccl5 , Cd40 , Il6 , Tlr3 , Tnf
Human InfluenzaCcl5 , Cd14 , Cd40 , Cd80 , Cd86 , Cxcl10 , Il12b , Il1b , Il6 , Irf7 , Stat1 , Tlr2 , Tlr3 , Tnf
Huntington's diseaseCasp8 , Il6 , Nfkb1
hydronephrosisIl1b
HyperalgesiaCcl5 , Fos , Il1b , Il6 , Map2k3 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Tlr2 , Tlr4 , Tnf
hypercalcemiaIl6 , Tnf
HypercholesterolemiaCd40 , Il1b
HyperemiaIl1b
HypergammaglobulinemiaTlr9
hyperglycemiaCasp8 , Il1b , Il6
hyperhomocysteinemiaIl1b , Tnf
hyperimmunoglobulin syndromeCd40
hyperinsulinismIl6
HyperkinesisFos
HyperoxaluriaCcl5 , Il6 , Nfkb1
HyperoxiaFadd , Il6 , Irak4 , Tnf
HyperplasiaAkt1 , Ikbkb , Pik3ca
hypertensionAkt1 , Akt2 , Casp8 , Ccl5 , Cd14 , Fadd , Fos , Ikbkb , Il1b , Il6 , Jun , Mapk8 , Myd88 , Nfkbia , Pik3r1 , Rela , Tlr4 , Tnf
Hypertension, Pregnancy-InducedTnf
hyperthyroidismCd40
HypertrophyMapk1 , Mapk3
HypoalbuminemiaIl6
hypochromic microcytic anemiaTnf
hypoglycemiaAkt2 , Il1b , Pik3r1 , Tnf
hypogonadismIl6
hypohidrotic ectodermal dysplasiaIkbkg , Traf6
Hypohidrotic Ectodermal Dysplasia, with Immune DeficiencyIkbkg
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
hypolipoproteinemiaIl1b
hypomelanosis of ItoIkbkg
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
HypotensionIl1b , Il6 , Tnf
HypothermiaCxcl10 , Il12a , Il12b , Tnf
hypothyroidismStat1
HypoventilationCcl5
Hypoxia-Ischemia, BrainCasp8 , Fadd , Il1b , Il6 , Irak1 , Irak4
idiopathic interstitial pneumoniaIl6
idiopathic pulmonary fibrosisTnf
IgA glomerulonephritisCd14 , Il1b , Tlr1 , Tlr9 , Tnf
ileitisCd80 , Tlr2 , Tlr4
Immediate HypersensitivityCcl5
Immunodeficiency 14Pik3cd
Immunodeficiency 15Ikbkb
IMMUNODEFICIENCY 28Ifnar1
IMMUNODEFICIENCY 29Il12b
Immunodeficiency 31AStat1
IMMUNODEFICIENCY 31BStat1
IMMUNODEFICIENCY 31CStat1
Immunodeficiency 36Pik3r1
Immunodeficiency 39Irf7
Immunodeficiency without Anhidrotic Ectodermal DysplasiaIkbkg
impotenceAkt1 , Il6 , Tnf
in situ carcinomaAkt1
inclusion body myopathy with Paget disease of bone and frontotemporal dementiaTnf
InflammationAkt1 , Ccl3 , Ccl5 , Cd40 , Chuk , Il1b , Il6 , Irf7 , Myd88 , Spp1 , Tlr2 , Tlr4 , Tlr6 , Tlr9 , Tnf
inflammatory bowel diseaseIkbkb , Il6 , Tnf
inflammatory bowel disease 14Irf5
inhalation anthraxCxcl10 , Cxcl11 , Cxcl9
Insulin ResistanceAkt2 , Casp8 , Ikbkb , Il1b , Il6 , Mapk3 , Pik3r1 , Rela , Tlr4 , Tnf
insulinomaCd40
intellectual disabilityFos
intermediate coronary syndromeAkt1
intermediate uveitisTnf
interstitial cystitisCxcl10 , Cxcl11 , Cxcl9 , Tnf
interstitial lung diseaseCcl5 , Cxcl10 , Cxcl9 , Tlr9
Intervertebral Disc DisplacementAkt1 , Tnf
Intestinal NeoplasmsMap2k1 , Map2k2 , Mapk8
Intestinal PolypsJun
Intestinal Reperfusion InjuryCd14 , Il6 , Lbp
intracranial aneurysmCtsk , Il6 , Tnf
Intracranial HemorrhagesIl6 , Tnf
intrahepatic cholestasis of pregnancyTnf
Intraventricular HemorrhageIl6
invasive aspergillosisTlr2 , Tlr4
invasive ductal carcinomaAkt1 , Map2k4
Invasive Pneumococcal Disease, Recurrent Isolated, 1Irak4 , Tirap
Invasive Pneumococcal Disease, Recurrent Isolated, 2Ikbkg
Invasive Pulmonary AspergillosisIl1b
IRAK4 DeficiencyIrak4
iron deficiency anemiaIl6 , Tnf
irritable bowel syndromeIkbkg
ischemiaAkt2 , Cxcl10 , Il6 , Mapk9
juvenile rheumatoid arthritisCd14 , Fos , Il6 , Jun , Mapk1
Kaposi's sarcomaIl6
Kawasaki diseaseCd40 , Il1b , Tlr4 , Tnf
Kearns-Sayre syndromeIl1b
keratitisIl6 , Tlr2 , Tlr4
keratoconjunctivitisTlr2
keratoconjunctivitis siccaIl6 , Tnf
keratoconusIl1b
Kidney CalculiSpp1
kidney diseaseCasp8 , Ccl5 , Mapk1 , Spp1 , Tnf
kidney failureCd80 , Il1b , Spp1 , Tlr2 , Tlr4
Kidney NeoplasmsAkt1 , Jun , Mapk1 , Mapk3
Kidney Reperfusion InjuryCd14 , Cd40 , Fos , Ikbkb , Il1b , Tlr2 , Tlr4 , Tnf
Klebsiella InfectionsIl6 , Tlr9
Kuhnt-Junius degenerationIl6 , Mapk8 , Tlr2 , Tlr3
labyrinthitisTnf
Language Development DisordersStat1
Laryngeal NeoplasmsSpp1
Latent TuberculosisTlr1
learning disabilityIkbkg , Il1b , Il6 , Tlr4
Leber hereditary optic neuropathyIl1b
Left Ventricular HypertrophyRac1 , Rela
legionellosisTlr5
Legionnaires' diseaseTlr5 , Tlr9
leishmaniasisIl6 , Tnf
Lennox-Gastaut syndromeMapk10
leprosyTlr1 , Tlr2 , Tnf
leptospirosisIl1b , Tlr2 , Tlr4
LethargyIl1b
leukemiaFadd
LeukocytosisIl1b
LeukoencephalopathiesSpp1
lichen diseaseIl6
lichen planusCd40 , Ripk1
listeriosisTnf
Liver AbscessStat1
liver benign neoplasmIl12a , Il12b , Jun , Map2k3 , Mapk14 , Tnf
liver cancerAkt1 , Casp8 , Pik3ca
liver cirrhosisCasp8 , Cd14 , Il6 , Lbp , Spp1 , Stat1 , Unc93b1
liver diseaseCd86 , Nfkb1 , Rac1 , Tnf
Liver InjuryIl6
Liver Reperfusion InjuryCasp8 , Cd14 , Cd40 , Fadd , Ikbkg , Il1b , Il6 , Lbp , Mapk8 , Tlr4 , Tnf , Tradd
localized sclerodermaTnf
low tension glaucomaTlr4 , Tnf
lung adenocarcinomaAkt1 , Map2k1 , Pik3ca , Pik3r1
lung cancerCasp8 , Map3k8 , Nfkbia , Pik3ca
lung diseaseCcl5 , Cd14 , Il1b , Il6 , Tlr2 , Tlr4 , Tnf
Lung InjuryCcl3 , Il6 , Nfkbia , Tlr4 , Tnf
Lung NeoplasmsAkt1 , Casp8 , Fos , Ikbkg , Il1b , Il6 , Jun , Map2k3 , Map2k7 , Map3k8 , Mapk1 , Mapk14 , Mapk3 , Pik3ca , Spp1 , Tlr4 , Tlr9 , Tnf
Lung Reperfusion InjuryIl1b , Tlr4 , Tnf
lung small cell carcinomaAkt1 , Pik3ca , Pik3r1
lung squamous cell carcinomaAkt1 , Pik3ca
lupus nephritisCcl3 , Cd40 , Il1b , Tlr7 , Tlr9 , Tnf
Lyme NeuroborreliosisCd40 , Il1b
lymphangioleiomyomatosisStat1
Lymphatic MetastasisCd40 , Pik3ca , Pik3cb , Rela , Tlr4
lymphomaMyd88 , Rela
lymphopeniaIl1b , Tnf
lymphoplasmacytic lymphomaMyd88
MacrocephalyAkt3
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
macular degenerationTlr4
macular retinal edemaIl6
malariaCd40 , Spp1 , Tirap , Tnf
Malarial AnemiaTlr9
Malformations of Cortical Development, Group IITlr6
malignant gliomaAkt2 , Cd40 , Cd80 , Il12a , Il12b , Map2k1 , Mapk3 , Pik3ca , Pik3r3 , Spp1 , Tnf
malignant mesotheliomaCcl3 , Ccl5 , Cd40 , Cxcl9 , Il12b , Il6
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Casp8 , Cd40 , Map2k3 , Map2k7 , Mapk1 , Mapk3 , Pik3r1 , Rela , Spp1 , Stat1 , Tnf
Manganese PoisoningIl1b , Tnf
mantle cell lymphomaPik3cd
mastitisTlr4 , Tlr9
mastoiditisRela , Tlr2 , Tlr4
medulloblastomaPik3ca
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
megaloblastic anemiaTraf3
Megaloblastic Anemia 1Traf3
melanomaAkt1 , Casp8 , Cd40 , Ifnb1 , Irf3 , Map2k1 , Map2k2 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rac1 , Spp1 , Tlr4 , Tnf
MELAS syndromeIl1b
melioidosisTlr5
membranoproliferative glomerulonephritisIl1b , Tlr1 , Tlr2 , Tlr4 , Tlr5 , Tlr6 , Tlr7 , Tlr8 , Tlr9
membranous glomerulonephritisCd40 , Il1b
Memory DisordersIl1b
Meningeal NeoplasmsAkt1
Meningeal TuberculosisTnf
meningiomaAkt1
Meningitis, Escherichia ColiTlr2 , Tlr4 , Tlr7
meningococcal meningitisTlr2 , Tlr4
mental depressionFadd , Il1b , Il6 , Jun
Mercury Poisoning, Nervous SystemJun
MERRF SyndromeIl1b
MesotheliomaSpp1
Metabolic SyndromeCcl5 , Fadd , Il6 , Lbp , Tnf
mevalonic aciduriaTnf
middle cerebral artery infarctionCd86 , Cxcl10 , Fadd , Fos , Ikbkb , Il1b , Il6 , Mapk1 , Mapk3 , Nfkbia , Tnf
migraineMap2k2 , Tab2 , Tnf
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1Tnf
migraine without auraTnf
milker's noduleTlr3
mitochondrial myopathyIl1b , Il6 , Tnf
Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal BonesMap3k7
mixed connective tissue diseaseTlr3 , Tnf
molluscum contagiosumTlr2
morphine dependenceFadd
motor neuron diseaseTbk1
Mouth NeoplasmsPik3ca
mucocutaneous leishmaniasisTnf
mucositisIl1b
Multiple AbnormalitiesChuk , Mapk1 , Pik3r2
Multiple Hamartoma SyndromePik3ca
multiple myelomaCd40 , Cd86 , Il1b , Il6 , Myd88 , Nfkbia , Pik3ca , Spp1 , Tnf
Multiple Organ FailureIl1b , Lbp , Mapk1 , Tnf
multiple sclerosisCcl5 , Cd40 , Cd86 , Ifnb1 , Il12a , Il1b , Il6 , Spp1 , Tlr4 , Tnf
Murine Acquired Immunodeficiency SyndromeCd40
muscular atrophyAkt1 , Chuk , Ikbkb , Tnf
muscular diseaseIl1b
muscular dystrophyTnf
myasthenia gravisCxcl10
Mycobacterium avium complex diseaseTnf
Mycobacterium InfectionsStat1
Mycobacterium Tuberculosis, Susceptibility To Infection ByTirap , Tlr2
Mycoplasma pneumoniae pneumoniaCcl5 , Tnf
MYD88 DeficiencyMyd88
myelodysplastic syndromeCd40 , Il1b , Tnf
myocardial infarctionAkt1 , Ccl5 , Cd14 , Il1b , Il6 , Mapk1 , Nfkbia , Spp1 , Tlr4 , Tnf
Myocardial IschemiaCcl3 , Cd40 , Cxcl10 , Il1b , Il6 , Map2k3 , Map3k8 , Mapk14 , Nfkbia , Tnf
Myocardial Reperfusion InjuryAkt1 , Akt2 , Casp8 , Fadd , Il1b , Il6 , Irak1 , Map2k6 , Mapk1 , Mapk14 , Mapk3 , Mapk8 , Myd88 , Nfkbia , Rela , Spp1 , Stat1 , Tlr2 , Tlr4 , Tnf
myocardial stunningTnf
myocarditisCxcl10 , Il6 , Irak1 , Spp1 , Tnf
myositisTnf
Nasal PolypsJun , Tlr2 , Tlr4 , Tlr7 , Tnf
Nasopharyngeal NeoplasmsPik3ca
NauseaTnf
NecrosisIl1b , Il6 , Tnf
Neisseriaceae InfectionsCd40
Nematode InfectionsPik3r1
Neonatal HyperbilirubinemiaIkbkb
Neoplasm InvasivenessCcl5 , Il1b , Il6 , Mapk1 , Mapk3 , Myd88 , Rela , Tlr4 , Tnf
Neoplasm MetastasisAkt2 , Ccl3 , Cd86 , Chuk , Fadd , Il6 , Ly96 , Mapk1 , Mapk3 , Mapk9 , Nfkb1 , Nfkbia , Pik3ca , Pik3r3 , Rac1 , Spp1 , Stat1 , Tlr4 , Tnf
Neoplasm Recurrence, LocalCxcl9
Neoplasms, Cystic, Mucinous, and SerousSpp1
neovascular glaucomaIl6
Neovascularization, PathologicSpp1
nephritisCasp8 , Ccl3
nephroblastomaStat1
nephrosisIl1b
nephrotic syndromeIl1b
Nerve DegenerationMapk1 , Mapk3 , Tnf
nervous system diseaseFos , Tnf
NeuralgiaTlr4 , Tnf
neuroblastomaIfnb1 , Map2k4 , Map2k7 , Pik3ca
neurodegenerative diseaseIl6
Neurogenic InflammationTnf
neuromyelitis opticaIl6
neuronal ceroid lipofuscinosis 6Mapk1 , Mapk3
neutropeniaIl1b , Tnf
Neutropenic EnterocolitisIl1b
non-Hodgkin lymphomaCd40 , Map2k1 , Myd88 , Pik3ca
non-small cell lung carcinomaAkt1 , Akt2 , Akt3 , Casp8 , Il1b , Map2k1 , Nfkb1 , Pik3ca , Rela , Spp1 , Tlr9 , Tnf
nonalcoholic fatty liver diseaseCd14 , Ikbkg , Il6 , Mapk8 , Tlr4 , Tnf
Nontuberculous Mycobacterium InfectionsIl12b , Stat1
Noonan syndromeMap2k1 , Map2k2
Noonan syndrome 1Map2k1
obesityAkt1 , Akt2 , Ccl5 , Cd40 , Fadd , Ikbkb , Il1b , Il6 , Lbp , Mapk1 , Mapk3 , Pik3r1 , Rela , Tlr2 , Tlr4 , Tnf
Obstetric Labor, PrematureIl6
obstructive jaundiceCd14 , Lbp
obstructive sleep apneaCcl5 , Il1b , Il6 , Rela , Tnf
Occupational AsthmaTnf
Onchocerciasis, OcularTlr4
open-angle glaucomaTnf
Optic Nerve InjuriesJun , Tlr4 , Tradd
Oral Lichen PlanusTlr2 , Tlr4 , Tlr9
oral squamous cell carcinomaIl6
oral submucous fibrosisIl6 , Tnf
orchitisCcl5 , Cd86
osteoarthritisIl1b , Tlr8
Osteoarthritis, ExperimentalCasp8 , Mapk3
OsteolysisSpp1 , Tnf
osteopetrosisCtsk , Jun
osteoporosisCtsk , Il1b , Il6 , Mapk14
osteosarcomaAkt1 , Jun
otitis mediaCtsk , Il1b , Il6 , Rela , Tlr2 , Tlr4 , Tnf
Otitis Media with EffusionIl1b , Tlr2 , Tlr4 , Tnf
ovarian cancerAkt1 , Pik3ca
ovarian cystNfkb1
ovarian hyperstimulation syndromeIl6
Ovarian NeoplasmsAkt1 , Akt2 , Ccl5 , Il6 , Map2k1 , Map2k2 , Map2k4 , Map2k6 , Map2k7 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Rela , Spp1 , Tlr4 , Tnf
ovarian serous cystadenocarcinomaPik3ca
Oxygen-Induced RetinopathyMapk8 , Tnf
PainAkt1 , Ccl5 , Tlr2 , Tlr4 , Tnf
Painful NeuropathyTlr4 , Tnf
pancreas diseaseIl6 , Spp1
pancreatic adenocarcinomaMap2k2 , Pik3ca
pancreatic cancerAkt1 , Akt2 , Akt3 , Casp8 , Ccl5 , Il1b , Map2k4 , Nfkbia , Rela , Spp1 , Tnf
Pancreatic CystIl1b
pancreatic ductal carcinomaCd40
pancreatic intraductal papillary-mucinous neoplasmAkt1
pancreatitisCcl5 , Cd14 , Ikbkb , Il1b , Tlr2 , Tlr3 , Tlr4
Pancreatitis, Experimental, Acute Tnf
Pancreatitis, Experimental, Chronic Il1b
papillary renal cell carcinomaPik3ca
papillomaMap2k4
Papillomavirus InfectionsCasp8 , Tlr3 , Tlr9
paracoccidioidomycosisTnf
Paramyxoviridae InfectionsCcl5 , Cxcl9
paraplegiaAkt1
Parkinson's diseaseAkt1 , Il1b , Il6 , Tnf
Parkinsonian DisordersIl1b , Rela , Tnf
Pediatric Crohn's DiseaseTnf
pemphigusCd40
penile neoplasmPik3ca
peptic esophagitisCcl5 , Tnf
peptic ulcer diseaseIl1b
Perennial Allergic RhinitisCd40 , Cd86
perinatal necrotizing enterocolitisCd14 , Cd40 , Ikbkg , Il1b , Tlr1 , Tlr2 , Tlr3 , Tlr4 , Tlr5 , Tlr6 , Tlr7 , Tlr9 , Tnf
periodontal diseaseCd80 , Il6
periodontitisCd14 , Il1b , Il6 , Lbp , Tnf
Peripheral Nerve InjuriesIl1b , Il6 , Tnf
peripheral nervous system diseaseIl6 , Jun , Tlr3
peripheral vascular diseaseIl6
peritonitisCd40 , Tnf
periventricular leukomalaciaTnf
Pick's diseaseFos , Map2k6
Picornaviridae InfectionsTnf
placenta diseaseTnf
plagueIl1b
Plaque, AtheroscleroticTlr2 , Tlr4
plasmacytic leukemiaCd40
plasmacytomaMyd88 , Pik3ca , Tnf
Plasmodium falciparum malariaTnf
pleomorphic xanthoastrocytomaIl6 , Irf5
pleural diseaseIl6
Pleural EffusionTnf
Pleural NeoplasmsSpp1
pleural tuberculosisIl1b , Tlr4
pleurisyCcl5 , Cxcl10 , Cxcl9 , Il1b , Il6 , Tnf
Pneumococcal InfectionsTirap , Tlr9
Pneumococcal MeningitisIl6 , Rela , Tlr2 , Tlr4 , Tlr9 , Tnf
Pneumococcal PneumoniaCcl5 , Cd14 , Cxcl9 , Il6 , Mapk1 , Mapk3 , Tlr2 , Tnf
pneumocystosisCd40 , Tlr2
pneumoniaCd14 , Cxcl10 , Cxcl9 , Ifnar1 , Ikbkb , Il1b , Il6 , Myd88 , Spp1 , Tlr2 , Tlr4 , Tnf
Pneumonia, StaphylococcalCd86 , Ifnar1 , Il1b
polycystic ovary syndromeAkt2 , Tab1
PolymicrogyriaAkt3
PolymyositisIl1b , Il6 , Tnf
polyneuropathyIl1b , Il6
portal hypertensionIl1b , Pik3r1
posterior uveitisCcl5
Postmenopausal OsteoporosisIl1b , Il6 , Tnf
Postoperative Atrial FibrillationIl6
Postoperative Cognitive DysfunctionIl1b
pre-eclampsiaCcl5 , Cd40 , Tlr3 , Tlr4 , Tnf
pre-malignant neoplasmAkt1 , Casp8 , Il6 , Map2k7 , Mapk8 , Mapk9 , Nfkbia
precursor lymphoblastic lymphoma/leukemiaCasp8 , Cd86
precursor T-lymphoblastic lymphoma/leukemiaStat1
prediabetes syndromeIl6
Pregnancy Complications, CardiovascularIl6 , Tnf
Premature BirthIl6 , Tnf
Presenile and Senile DementiaIl1b
primary biliary cirrhosisCcl5 , Cd80 , Cxcl10 , Cxcl9 , Il12a , Il12b , Mapk14 , Nfkb1 , Rela
primary immunodeficiency diseaseCasp8 , Stat1
primary open angle glaucomaTlr4 , Tnf
Progressive Osseous HeteroplasiaSpp1
progressive supranuclear palsyMap2k6
proliferative vitreoretinopathyIl6
prostate adenocarcinomaAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Map2k1 , Mapk1 , Nfkbia , Pik3ca , Pik3cb , Rela
prostate cancerAkt2 , Akt3 , Chuk , Ikbkb , Mapk10 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3r1 , Pik3r2
prostate carcinomaAkt2
prostate carcinoma in situMap2k4 , Map2k6 , Map2k7 , Rela
prostatic hypertrophyFadd , Rela
Prostatic NeoplasmsAkt1 , Chuk , Il6 , Irak4 , Jun , Map2k1 , Map2k4 , Map2k6 , Map2k7 , Map3k7 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Rela , Spp1 , Stat1 , Tirap , Tlr2 , Tlr4 , Tlr5 , Tlr6 , Tnf
proteinuriaCxcl10 , Il6 , Spp1 , Tlr9
Proteus syndromeAkt1
Pseudomonas Aeruginosa KeratitisIl1b , Il6 , Tlr2 , Tlr4
Pseudomonas InfectionsCcl5 , Il1b , Tlr5 , Tnf
psoriasisCd40 , Ikbkb , Il12b , Il1b , Il6 , Irak1 , Nfkbia , Tlr2 , Tlr4 , Tnf
psoriatic arthritisIl12b , Irak1 , Tnf
PTEN hamartoma tumor syndromePik3ca
Pulmonary ContusionIl6
pulmonary edemaIl1b , Tlr4 , Tnf
pulmonary emphysemaCxcl10 , Cxcl9 , Jun , Nfkbia , Tlr2 , Tlr4 , Tnf
pulmonary fibrosisCcl3 , Ccl5 , Cd86 , Il12b , Il1b , Il6 , Spp1 , Stat1 , Tlr2 , Tlr4 , Tlr9 , Tnf
pulmonary hypertensionCcl5 , Cd40 , Cd86 , Il1b , Il6 , Mapk1 , Mapk3 , Rela , Tlr4 , Tnf
pulmonary sarcoidosisCcl5 , Cxcl10 , Cxcl11 , Cxcl9 , Tlr2 , Tnf
pulmonary tuberculosisCcl5 , Cd14 , Cd86 , Il1b , Il6 , Jun , Tlr1 , Tlr2 , Tlr4 , Tlr9 , Tnf
pulpitisTlr4
pycnodysostosisCtsk
pyelonephritisTlr1
quadriplegiaIl6
Radiation Injuries, ExperimentalCasp8 , Il1b , Mapk1 , Mapk3 , Tnf
Radiation PneumonitisTnf
radiculopathySpp1 , Tnf
RASopathiesMap2k1 , Map2k2
rectal neoplasmFos , Mapk8 , Pik3ca , Pik3cb
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsFadd
Refractory AnemiaTnf
relapsing polychondritisTnf
relapsing-remitting multiple sclerosisCd80
renal artery obstructionCd40
renal carcinomaPik3ca
renal cell carcinomaAkt1 , Akt3 , Cd40 , Il6 , Jun , Map2k1 , Mapk1 , Pik3ca , Pik3r1 , Rela , Tlr9 , Tnf
renal fibrosisCcl3 , Mapk1 , Tlr2 , Tlr4
renal hypertensionIl6 , Tnf
renovascular hypertensionCxcl10 , Rela , Spp1
Reoviridae InfectionsStat1
Reperfusion InjuryAkt1 , Casp8 , Ccl3 , Ccl5 , Cd40 , Cxcl10 , Cxcl9 , Fos , Il12a , Il1b , Il6 , Jun , Mapk8 , Mapk9 , Myd88 , Pik3r1 , Rela , Spp1 , Stat1 , Tlr2 , Tlr3 , Tlr4 , Tnf
Respiration DisordersCcl5
respiratory allergyIl1b , Il6 , Tlr4 , Tnf
Respiratory SoundsTlr4 , Tlr9
respiratory syncytial virus infectious diseaseCcl5 , Cxcl10 , Cxcl9 , Il6 , Tlr2 , Tlr3 , Tlr4 , Tlr6 , Tlr7 , Tlr8 , Tnf
respiratory system diseaseTnf
Respiratory Tract InfectionsIrf3 , Tnf
restrictive cardiomyopathyMap2k3 , Map2k6 , Mapk14
Retina Reperfusion InjuryIl1b , Il6 , Map2k4 , Tlr4 , Tnf
retinal artery occlusionIl6 , Tnf
retinal detachmentCasp8 , Il6 , Tnf
retinal diseaseMap2k3 , Tnf
retinal vasculitisIl6
retinal vein occlusionIl1b , Il6
retinitisIl1b
retinitis pigmentosaRipk1
retinopathy of prematurityIl1b
Rett syndromeIrak1
rheumatoid arthritisCd40 , Cd80 , Il1b , Il6 , Irak1 , Irf5 , Ly96 , Spp1 , Stat1 , Tlr2 , Tnf , Traf6
rhinitisCd14 , Cd80 , Il1b , Tlr2 , Tlr6 , Tnf
RhinosinusitisIl1b , Tlr2 , Tlr4 , Tnf
Right Ventricular HypertrophyAkt1
root resorptionTnf
Salmonella Infections, AnimalTlr5
salmonellosisIl12b
Sandhoff diseaseCcl3
sarcoidosisCd14
sarcomaPik3ca , Tnf
SarcopeniaIl6 , Nfkbia
Schistosomiasis MansoniCd40 , Cd86 , Tlr9
schizophreniaAkt1 , Il1b , Il6 , Map2k7 , Mapk3 , Pik3cb , Tnf
sciatic neuropathyCasp8 , Ccl5 , Il1b , Il6 , Nfkbia , Tlr2 , Tlr4 , Tnf
scleritisTnf
scrapieCcl5 , Spp1 , Stat1
Seasonal Allergic RhinitisCcl5 , Tlr3 , Tlr4
seborrheic dermatitisTlr2
seborrheic keratosisPik3ca
secondary hyperparathyroidismIl6
Seizures, FebrileIl1b
Senior-Loken syndromeAkt3
Senior-Loken Syndrome 7Akt3
sensorineural hearing lossFadd , Tnf
SepsisCasp8 , Ccl5 , Cd40 , Il12b , Il1b , Il6 , Irak4 , Lbp , Mapk1 , Mapk3 , Rela , Stat1 , Tlr2 , Tlr4 , Tnf
septic arthritisTnf
Septic PeritonitisIl6 , Pik3r1
severe acute respiratory syndromeCxcl10 , Cxcl9
Sezary's diseaseMapk1
ShockMapk1 , Mapk3 , Tnf
Shock, HemorrhagicCasp8 , Il1b , Il6 , Mapk1 , Rela , Tnf
SHORT SyndromePik3r1
Shwartzman phenomenonIl6
sickle cell anemiaTnf
silicosisIl1b , Tnf
sinusitisIl1b , Tlr2 , Tlr4 , Tlr9
Sjogren's syndromeIl12a , Il6 , Nfkbia , Tnf
Skin AbnormalitiesChuk
skin cancerChuk
skin diseaseIl1b , Il6 , Tnf
skin melanomaAkt1 , Cd40 , Map2k1 , Map2k2 , Pik3ca , Rac1
Skin NeoplasmsAkt1 , Casp8 , Map2k4 , Rela
skin papillomaTlr2
Sleep DeprivationMap2k4
sleep disorderIl1b
small cell carcinomaIl6 , Tnf
Small-For-Size SyndromeIl1b
Smith-Magenis syndromeCcl3 , Ccl5 , Map2k2 , Map2k3 , Map2k6
Soft Tissue NeoplasmsTnf
Spinal Cord CompressionTnf
Spinal Cord InjuriesAkt1 , Ccl5 , Cxcl10 , Fadd , Il1b , Il6 , Jun , Nfkbia , Rela , Spp1 , Tlr1 , Tnf
Spinal Cord Reperfusion InjuryTlr4
spondyloarthropathyIl6 , Tnf
Spondylocostal Dysostosis 5Mapk3
Sporadic Papillary Renal Cell CarcinomaPik3ca
sporotrichosisTlr4
squamous cell carcinomaAkt1 , Il6 , Irak1 , Mapk1 , Mapk3 , Pik3ca , Ripk1 , Tlr9
Staphylococcal InfectionsTlr2
status asthmaticusIl1b
status epilepticusCasp8 , Ccl3 , Cd40 , Fos , Il1b , Jun , Rela , Tnf
Stevens-Johnson syndromeTnf
stomach cancerIl1b , Pik3ca
Stomach NeoplasmsCasp8 , Il1b , Il6 , Jun , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Spp1 , Tnf
Stomatognathic DiseasesFadd
Streptococcal InfectionsCd86 , Tlr2
StrokeAkt1 , Cd40 , Il1b , Il6 , Mapk8 , Pik3ca , Tlr4 , Tnf
Subacute Combined DegenerationCd40
Subarachnoid HemorrhageTlr4 , Tnf
Subretinal FibrosisIl6
substance-induced psychosisAkt1
Sudden Death, CardiacIl6
suppurative otitis mediaTlr2 , Tlr4
Systemic CandidiasisTnf
Systemic Inflammatory Response SyndromeIl1b
Systemic Juvenile Rheumatoid ArthritisIl6
systemic lupus erythematosusCd40 , Cd80 , Il12b , Il1b , Il6 , Irak4 , Irf5 , Tlr4 , Tlr5 , Tlr7 , Tlr9 , Tnf
systemic sclerodermaCcl3 , Cd86 , Cxcl10 , Cxcl9 , Il1b , Il6 , Irak1 , Irf5
T-Cell LymphomaAkt1
TachycardiaTnf
temporal arteritisTlr4
Temporomandibular Joint DisordersTnf
Tendon InjuriesFos
Testis Reperfusion InjuryMapk1 , Mapk3
thalassemiaIl1b , Tnf
thoracic aortic aneurysmCxcl10 , Cxcl9
thrombocytopeniaIl1b , Il6 , Tnf
thrombocytosisIl1b
thrombosisCd40 , Pik3cb , Tnf
thyroid cancerMapk1
Thyroid NeoplasmsAkt1 , Akt2 , Cxcl10 , Il12b , Il1b , Il6 , Map2k3 , Pik3ca , Spp1 , Tnf
tick-borne encephalitisCd40
Tissue AdhesionsCcl5
Tobacco Use DisorderIl6 , Tlr3
Tongue NeoplasmsFos , Tlr5 , Tnf
toxic encephalopathyFos
toxic shock syndromeIl6 , Tnf
Toxoplasma ChorioretinitisIl6
trachomaTnf
transient cerebral ischemiaCasp8 , Cd40 , Ikbkb , Il1b , Map2k4 , Nfkb1 , Tnf
transitional cell carcinomaAkt1 , Ifnb1 , Map2k1 , Mapk1 , Pik3ca , Tnf
Transplant RejectionCcl3 , Cd40 , Ikbkb , Il1b , Nfkbia , Tlr2 , Tlr4 , Tlr9 , Tnf
Transverse MyelitisIl6
Trauma, Nervous SystemSpp1 , Stat1
trichinosisTnf
trigeminal neuralgiaFos , Il1b , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Tnf
tuberculosisCd86 , Cxcl9 , Spp1 , Tirap , Tlr1 , Tlr4 , Tlr6 , Tnf
tularemiaCd86
Tympanic Membrane PerforationIl6
tympanosclerosisTlr4
type 1 diabetes mellitusCasp8 , Ccl5 , Cd14 , Cd40 , Cd80 , Cd86 , Cxcl10 , Il1b , Il6 , Tlr2 , Tlr3 , Tlr4 , Tnf
type 1 diabetes mellitus 5Tab2
type 2 diabetes mellitusAkt1 , Akt2 , Casp8 , Ccl5 , Cxcl10 , Ikbkb , Il1b , Il6 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3cb , Pik3r1 , Rela , Tlr4 , Tnf
ulcerative colitisCd40 , Il12b , Il1b , Irf5 , Rela , Tnf
uremiaSpp1
ureteral obstructionAkt1 , Cd14 , Il1b , Mapk1 , Mapk3 , Rela , Tlr9 , Tnf
urethral obstructionMapk1
urinary bladder cancerAkt1 , Ifnb1 , Il1b , Map2k4 , Rela , Spp1 , Tlr2 , Tlr4 , Tnf
Urinary CalculiSpp1
Urinary IncontinenceMapk1
Urinary Tract InfectionsIl1b , Tlr2 , Tlr4
urticariaIl1b , Tnf
uterine carcinosarcomaPik3ca , Pik3r1
Uterine Cervical NeoplasmsAkt1 , Casp8 , Fos , Map2k3 , Map2k6 , Mapk1 , Pik3ca , Rela , Tnf
Uterine NeoplasmsMap2k1 , Pik3ca , Pik3r1 , Rac1
uveitisCcl5 , Cxcl10 , Il1b , Il6 , Rela , Tlr4 , Tnf
varicoceleIl1b
Vascular CalcificationCd40
vascular dementiaIl1b , Tnf
vascular diseaseTnf
Vascular MalformationsPik3ca
Vascular System InjuriesSpp1 , Tnf
velocardiofacial syndromeMapk1
Venous ThromboembolismTnf
Venous ThrombosisIl1b
Ventilator-Induced Lung InjuryAkt1 , Il1b , Nfkbia
Ventricular DysfunctionTnf
Ventricular Dysfunction, LeftIl6 , Rac1 , Tlr4
ventricular septal defectFos
Viral BronchiolitisCcl5 , Cd14 , Cxcl10 , Il6 , Tlr4 , Tlr5 , Tnf
Viral Hepatitis, AnimalCd40
viral infectious diseaseIfnar1
viral meningitisTlr4
Viral MyocarditisCasp8 , Cd40 , Cd80 , Cd86
viral pneumoniaCxcl10 , Cxcl9 , Ifnar1 , Tlr9 , Tnf
visceral leishmaniasisCd40 , Il1b , Il6 , Tnf
visual epilepsyCcl5 , Fos , Ifnb1 , Il1b , Il6 , Pik3ca , Spp1 , Tnf
vitiligoCd80 , Pik3r1 , Tlr2 , Tlr4 , Tnf
Vogt-Koyanagi-Harada diseaseTnf
Vulvar VestibulitisIl1b , Tnf
Waldenstroem's macroglobulinemiaIl6 , Myd88
Wallerian DegenerationTlr2 , Tlr4
Weight GainLbp , Pik3ca , Tnf
Weight LossCd14
Weill-Marchesani syndromeTnf
Weissenbacher-Zweymuller syndromeMapk1
Wilson diseaseIl6 , Tnf
withdrawal disorderFos , Mapk1 , Mapk3
Wolff-Parkinson-White syndromeMap3k7
Wounds and InjuriesIl6 , Spp1 , Tnf
Wounds, PenetratingTnf
X-linked adrenal hypoplasia congenitaTab3
Pathway Annotations Associated with Genes in the Toll-like receptor signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela
adenosine signaling pathwayAkt1 , Chuk , Ikbkb , Jun , Map2k2 , Map2k6 , Map2k7 , Mapk1 , Mapk11 , Mapk8 , Nfkb1 , Nfkbia , Pik3ca
aldosterone signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
allograft rejection pathwayCd40 , Cd80 , Cd86 , Il12a , Il12b , Tnf
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap2k1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
altered ubiquitin/proteasome degradation pathwayUbe2n
Alzheimer's disease pathwayCasp8 , Fadd , Il1b , Mapk1 , Mapk3 , Tnf , Ube2n
amyotrophic lateral sclerosis pathwayMap2k3 , Map2k6 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Rac1 , Tnf
antigen processing and presentation pathwayTnf
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Il1b , Irak1 , Irak2 , Irak4 , Myd88 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Ripk1 , Tnf , Tradd
Arf family mediated signaling pathwayRac1
asthma pathwayCd40 , Tnf
ataxia telangiectasia-mutated (ATM) signaling pathwayUbe2n
autoimmune thyroiditis pathwayCd40 , Cd80 , Cd86 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , LOC100911527
autophagy pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , LOC100911527
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Fos , Ikbkb , Ikbkg , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela
Bone morphogenetic proteins signaling pathwayMap3k7 , Mapk1 , Tab1 , Tab2
c-Jun N-terminal kinases MAPK signaling pathwayMap2k4 , Map2k7 , Map3k7 , Mapk10 , Mapk8 , Mapk9 , Rac1 , Spp1
cardiovascular system disease pathwayCd14
cell-extracellular matrix signaling pathwaySpp1
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k1 , Map2k2 , Map2k4 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela , Ripk1 , Stat1 , Tnf , Tradd
Chagas disease pathwayAkt1 , Akt2 , Akt3 , Casp8 , Ccl3 , Ccl5 , Chuk , Fadd , Fos , Ifnb1 , Ikbkb , Ikbkg , Il12a , Il12b , Il1b , Il6 , Irak1 , Irak4 , Jun , Map2k4 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Myd88 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tlr2 , Tlr4 , Tlr6 , Tlr9 , Tnf , Traf6
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Ccl3 , Ccl5 , Chuk , Cxcl10 , Cxcl11 , Cxcl9 , Ikbkb , Ikbkg , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela , Stat1
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Fos , Jun , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
cytokine mediated signaling pathwayCcl3 , Ccl5 , Cd40 , Cxcl10 , Cxcl11 , Cxcl9 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Il12a , Il12b , Il1b , Il6 , LOC100911527 , Tnf
diabetic nephropathy pathwaySpp1
dilated cardiomyopathy pathwayTnf
E-cadherin signaling pathwayAkt1 , Akt2 , Pik3ca , Pik3r1 , Rac1
eicosanoid signaling pathwayAkt1 , Mapk11 , Mapk14 , Pik3r5 , Rac1
endocytosis pathwayTraf6
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Endoplasmic Reticulum-associated degradation pathwayMap2k7 , Mapk10 , Mapk8 , Mapk9
endothelin signaling pathwayAkt1 , Fos , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk14 , Mapk3 , Mapk8 , Rac1
Entamoebiasis pathwayCd14 , Il12a , Il12b , Il1b , Il6 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tlr2 , Tlr4 , Tnf
ephrin - ephrin receptor bidirectional signaling axisMap2k1 , Map2k4 , Map3k7 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1 , Pik3r5 , Rac1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Jun , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1
erythropoietin signaling pathwayMapk14 , Mapk8 , Nfkb1 , Pik3r1 , Stat1
extrinsic apoptotic pathwayCasp8
FasL mediated signaling pathwayAkt1 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k6 , Map2k7 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Map2k3 , Map2k4 , Map2k6 , Map2k7 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Tnf
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
fibroblast growth factor signaling pathwayAkt1 , Fos , Jun , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Spp1 , Stat1
forkhead class A signaling pathwayAkt1 , Fos , Jun
glioma pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
glutamate signaling pathwayMapk1 , Mapk3
glypican signaling pathwayMapk8 , Mapk9
gonadotropin-releasing hormone signaling pathwayJun , Map2k1 , Map2k2 , Map2k3 , Map2k4 , Map2k6 , Map2k7 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9
graft-versus-host disease pathwayCd80 , Cd86 , Il1b , Il6 , Tnf
granulocyte-macrophage colony-stimulating factor signaling pathwayFos , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Stat1
Hedgehog signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
hepatitis C pathwayAkt1 , Akt2 , Akt3 , Chuk , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ikbkb , Ikbke , Ikbkg , Irf3 , Irf7 , LOC100911527 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Ripk1 , Stat1 , Tbk1 , Tlr3 , Tnf , Tradd , Traf3 , Traf6
Huntington's disease pathwayCasp8
hypertrophic cardiomyopathy pathwayIl6 , Tnf
hypoxia inducible factor pathwayAkt1 , Fos , Jun
inflammatory response pathwayMapk8
influenza A pathwayAkt1 , Akt2 , Akt3 , Ccl5 , Cxcl10 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ikbkb , Ikbke , Il12a , Il12b , Il1b , Il6 , Irak4 , Irf3 , Irf7 , Jun , LOC100911527 , Map2k1 , Map2k2 , Map2k3 , Map2k4 , Map2k6 , Map2k7 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Myd88 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Stat1 , Tbk1 , Tlr3 , Tlr4 , Tlr7 , Tnf
innate immune response pathwayCd14
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Rac1
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
insulin-like growth factor signaling pathwayAkt1 , Pik3ca , Pik3r1
interleukin-1 signaling pathwayChuk , Ikbkb , Ikbkg , Il1b , Irak1 , Irak2 , Irak4 , Jun , Map2k6 , Map3k7 , Mapk8 , Myd88 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Ticam2 , Tollip , Traf6 , Ube2n , Ube2v1
Interleukin-10 signaling pathwayStat1
interleukin-12 signaling pathwayCcl3 , Fos , Il12a , Il12b , Il1b , Map2k3 , Map2k6 , Mapk14 , Nfkb1 , Rela , Stat1
interleukin-2 signaling pathwayFos , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk11 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3r1 , Stat1
interleukin-23 signaling pathwayCxcl9 , Il12b , Il1b , Il6 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Stat1 , Tnf
interleukin-27 signaling pathwayIl12a , Il12b , Il1b , Il6 , Stat1 , Tnf
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Mapk14 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Fos , Il6 , Jun , Lbp , Map2k4 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Rac1 , Stat1
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Il12a , Il12b , Il6 , LOC100911527 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1
kidney disease pathwaySpp1
Leishmaniasis pathwayFos , Il12a , Il12b , Il1b , Irak1 , Irak4 , Jun , Map3k7 , Mapk1 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Myd88 , Nfkb1 , Nfkbia , Rela , Stat1 , Tlr2 , Tlr4 , Tnf , Traf6
long term depressionMap2k1 , Map2k2 , Mapk1 , Mapk3
long term potentiationMap2k1 , Map2k2 , Mapk1 , Mapk3
malaria pathwayCd40 , Il12a , Il1b , Il6 , Myd88 , Tlr2 , Tlr4 , Tlr9 , Tnf
measles pathwayAkt1 , Akt2 , Akt3 , Chuk , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ikbke , Il12a , Il12b , Il1b , Il6 , Irak1 , Irak4 , Irf3 , Irf7 , LOC100911527 , Map3k7 , Myd88 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Stat1 , Tbk1 , Tlr2 , Tlr4 , Tlr7 , Tlr9 , Traf6
melanoma pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Cd14 , Chuk , Fos , Ikbkb , Ikbkg , Il1b , Jun , Map2k1 , Map2k2 , Map2k3 , Map2k4 , Map2k6 , Map2k7 , Map3k7 , Map3k8 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Rac1 , Rela , Tnf , Traf6
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
myocarditis pathwayCasp8 , Cd40 , Cd80 , Cd86 , Rac1
N-cadherin signaling pathwayMapk8 , Pik3ca , Pik3r1 , Rac1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Irak1 , Irak2 , Irak4 , Jun , Map2k1 , Map2k2 , Map2k7 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela , Traf6
NOD-like receptor signaling pathwayCasp8 , Ccl5 , Chuk , Ikbkb , Ikbkg , Il1b , Il6 , Map3k7 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Nfkbia , Rela , Tnf , Traf6
non-small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
nuclear factor kappa B signaling pathwayChuk , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Tnf , Traf6
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb
p38 MAPK signaling pathwayMap2k3 , Map2k6 , Map3k7 , Map3k8 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Rac1 , Tab1 , Tab2 , Traf6
p53 signaling pathwayAkt1 , Casp8 , Mapk14 , Mapk8 , Mapk9
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela , Stat1
phagocytosis pathwayCd14 , Rac1 , Tlr2 , Tlr4 , Tlr6
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
platelet-derived growth factor signaling pathwayFos , Jun , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Stat1
primary immunodeficiency pathwayCd40 , Ikbkg
prion disease pathwayCcl5 , Il1b , Il6 , Map2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela
Reelin signaling pathwayAkt1 , Map2k7 , Mapk8 , Pik3ca , Pik3r1
renal cell carcinoma pathwayAkt1 , Akt2 , Akt3 , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8 , Chuk , Cxcl10 , Fadd , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnb1 , Ikbkb , Ikbke , Ikbkg , Il12a , Il12b , Irf3 , Irf7 , LOC100911527 , Map3k7 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk8 , Mapk9 , Nfkb1 , Nfkbia , Rela , Ripk1 , Tbk1 , Tnf , Tradd , Traf3 , Traf6
rheumatoid arthritis pathwayCcl3 , Ccl5 , Cd80 , Cd86 , Ctsk , Fos , Il1b , Il6 , Jun , Tlr2 , Tlr4 , Tnf
Rho/Rac/Cdc42 mediated signaling pathwayJun , Map2k4 , Mapk8 , Rac1
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
sleeping sickness pathwayIl12a , Il12b , Il1b , Il6 , Myd88 , Tlr9 , Tnf
small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Traf3 , Traf6
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Fos , Jun , Mapk1 , Mapk14 , Mapk3 , Mapk8 , Rac1
syndecan signaling pathwayCcl5 , Mapk1 , Mapk3 , Mapk8 , Rac1
systemic lupus erythematosus pathwayCd40 , Cd80 , Cd86 , Tnf
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Fos , Ikbkb , Ikbkg , Jun , Map2k1 , Map2k2 , Map2k7 , Map3k7 , Map3k8 , Mapk1 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk9 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tnf
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3 , Spp1
thyroid cancer pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3
tioguanine pharmacodynamics pathwayRac1
titanium dioxide nanoparticle response pathwayCasp8 , Tlr4
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Casp8 , Ccl3 , Ccl5 , Cd14 , Cd40 , Cd80 , Cd86 , Chuk , Ctsk , Cxcl10 , Cxcl11 , Cxcl9 , Fadd , Fos , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ikbkb , Ikbke , Ikbkg , Il12a , Il12b , Il1b , Il6 , Irak1 , Irak2 , Irak4 , Irf3 , Irf5 , Irf7 , Jun , Lbp , LOC100911527 , Ly96 , Map2k1 , Map2k2 , Map2k3 , Map2k4 , Map2k6 , Map2k7 , Map3k7 , Map3k8 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Myd88 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela , Ripk1 , Spp1 , Stat1 , Tab1 , Tab2 , Tab3 , Tbk1 , Ticam2 , Tirap , Tlr1 , Tlr2 , Tlr3 , Tlr4 , Tlr5 , Tlr6 , Tlr7 , Tlr8 , Tlr9 , Tnf , Tollip , Tradd , Traf3 , Traf6 , Ube2n , Ube2v1 , Unc93b1
toxoplasmosis pathwayAkt1 , Akt2 , Akt3 , Casp8 , Cd40 , Chuk , Ikbkb , Ikbkg , Il12a , Il12b , Irak1 , Irak4 , Ly96 , Map2k3 , Map2k6 , Map3k7 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Myd88 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Stat1 , Tlr2 , Tlr4 , Tnf , Traf6
Trail mediated signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Tradd
transforming growth factor-beta Smad dependent signaling pathwayMap3k7 , Tab1 , Tab2
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Tnf
tuberculosis pathwayAkt1 , Akt2 , Akt3 , Casp8 , Cd14 , Fadd , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnb1 , Il12a , Il12b , Il1b , Il6 , Irak1 , Irak2 , Irak4 , Lbp , LOC100911527 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Myd88 , Nfkb1 , Rela , Stat1 , Tirap , Tlr2 , Tlr4 , Tlr6 , Tlr9 , Tnf , Tradd , Traf6
tumor necrosis factor mediated signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k3 , Map2k7 , Map3k7 , Nfkb1 , Rela , Ripk1 , Stat1 , Tab1 , Tab2 , Tab3 , Tnf , Tradd
type 1 diabetes mellitus pathwayCd80 , Cd86 , Il12a , Il12b , Il1b , Tnf
type 2 diabetes mellitus pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tnf
type I interferon signaling pathwayIfnar1
type II interferon signaling pathwayAkt1 , Il1b , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Stat1
ubiquitin/proteasome degradation pathwayTraf6 , Ube2n
urinary bladder cancer pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Map2k3 , Map2k6 , Mapk1 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
Wnt signaling pathwayJun , Map3k7 , Mapk10 , Mapk8 , Mapk9 , Rac1
Wnt signaling, non-canonical pathwayMap3k7 , Mapk10 , Mapk8 , Mapk9 , Rac1 , Tab1 , Tab2
Wnt signaling, the planar cell polarity pathwayRac1
Phenotype Annotations Associated with Genes in the Toll-like receptor signaling pathway

References Associated with the Toll-like receptor signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: