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Gene: Arrb2 (arrestin, beta 2) Rattus norvegicus
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Symbol: Arrb2
Name: arrestin, beta 2
Description: Exhibits several functions, including 14-3-3 protein binding activity; G protein-coupled receptor binding activity; and arrestin family protein binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of apoptotic process; and regulation of signal transduction. Localizes to several cellular components, including the basolateral plasma membrane; dendritic spine; and postsynaptic density. Biomarker of hypertension; portal hypertension; and type 2 diabetes mellitus. Orthologous to human ARRB2 (arrestin beta 2); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; angiotensin II signaling pathway via AT1 receptor; corticotropin-releasing hormone signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 4,4'-diaminodiphenylmethane; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: arrestin beta-2; BARRES; beta-arrestin-2; MGC105502
Orthologs:
Homo sapiens (human) : ARRB2 (arrestin beta 2)  HGNC  Alliance
Mus musculus (house mouse) : Arrb2 (arrestin, beta 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arrb2 (arrestin beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ARRB2 (arrestin beta 2)
Canis lupus familiaris (dog) : ARRB2 (arrestin beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Arrb2 (arrestin beta 2)
Sus scrofa (pig) : ARRB2 (arrestin beta 2)
more info ...
Related Pseudogenes: Arrb2-ps  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01057,040,252 - 57,048,045 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,040,267 - 57,048,134 (+)Ensembl
Rnor_5.01056,797,489 - 56,805,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,244,071 - 57,284,166 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11057,289,995 - 57,297,789 (+)NCBI
Celera1054,285,120 - 54,301,063 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Arrb2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2157
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.