Enables several functions, including 14-3-3 protein binding activity; G protein-coupled receptor binding activity; and arrestin family protein binding activity. Involved in several processes, including regulation of apoptotic process; regulation of protein modification process; and regulation of signal transduction. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and postsynaptic membrane. Biomarker of hepatocellular carcinoma; hypertension; portal hypertension; and type 2 diabetes mellitus. Orthologous to human ARRB2 (arrestin beta 2); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; angiotensin II signaling pathway via AT1 receptor; corticotropin-releasing hormone signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine inhibits the reaction [[OPRM1 protein co-treated with Enkephalin more ...
[[GCG protein binds to and results in increased activity of GLP1R protein] which results in increased chemical synthesis of Cyclic AMP] promotes the reaction [ARRB2 protein binds to GLP1R protein] and [[GCG protein binds to and results in increased activity of GLP1R protein] which results in increased chemical synthesis of Cyclic AMP] which affects the localization of ARRB2 protein
[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of ARRB2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of ARRB2 mRNA
[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of ARRB2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of ARRB2 mRNA
ARRB2 protein promotes the reaction [carvedilol promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]] more ...
chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 mRNA] and chrysin inhibits the reaction [Diethylnitrosamine results in increased expression of ARRB2 protein]
ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK1 protein]] and ARRB2 protein promotes the reaction [Dobutamine promotes the reaction [[ADRB1 protein co-treated with EGFR protein] results in increased phosphorylation of MAPK3 protein]]
Dopamine promotes the reaction [DRD2 protein affects the localization of ARRB2 protein] and GRK2 protein promotes the reaction [Dopamine promotes the reaction [DRD2 protein affects the localization of ARRB2 protein]]
[Plant Extracts co-treated with Resveratrol] results in decreased expression of ARRB2 mRNA and ARRB2 protein affects the reaction [Resveratrol results in decreased expression of GSK3B protein modified form]
Rimonabant inhibits the reaction [1-pentyl-3-(1-naphthoyl)indole promotes the reaction [ARRB2 protein binds to CNR1 protein]] and Rimonabant inhibits the reaction [1-pentyl-3-(1-naphthoyl)indole promotes the reaction [ARRB2 protein binds to CNR2 protein]]
Differences in the C-terminus contribute to variations in trafficking between rat and human 5-HT(2A) receptor isoforms: identification of a primate-specific tripeptide ASK motif that confers GRK-2 and beta arrestin-2 interactions.
Reactive oxygen species are involved in regulating hypocontractility of mesenteric artery to norepinephrine in cirrhotic rats with portal hypertension.
c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during clathrin- mediated internalization.
Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor.
Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50.
The expression change of beta-arrestins in fibroblast-like synoviocytes from rats with collagen-induced arthritis and the effect of total glucosides of paeony.
involved in desensitization of the 2-adrenergic receptor and in the recruitment of a variety of cytosolic proteins to their sites of action at the plasma membrane
