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Gene: MAPK1 (mitogen-activated protein kinase 1) Homo sapiens
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Symbol: MAPK1
Name: mitogen-activated protein kinase 1
Description: Exhibits identical protein binding activity; phosphatase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of macromolecule metabolic process; protein phosphorylation; and response to epidermal growth factor. Localizes to the cytoplasm and nucleus. Implicated in adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Biomarker of several diseases, including Alzheimer's disease; childhood pilocytic astrocytoma; endocrine gland cancer (multiple); endometrial carcinoma (multiple); and obesity.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ERK; ERK-2; ERK2; ERT1; extracellular signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAPK 2; MAPK2; mitogen activated protein kinase 1; mitogen-activated protein kinase 2; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2; protein tyrosine kinase ERK2
Orthologs:
Mus musculus (house mouse) : Mapk1 (mitogen-activated protein kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mapk1 (mitogen activated protein kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mapk1 (mitogen-activated protein kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MAPK1 (mitogen-activated protein kinase 1)
Canis lupus familiaris (dog) : MAPK1 (mitogen-activated protein kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mapk1 (mitogen-activated protein kinase 1)
Sus scrofa (pig) : MAPK1 (mitogen-activated protein kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382221,759,657 - 21,867,680 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372222,113,946 - 22,221,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,443,946 - 20,551,970 (-)NCBINCBI36hg18NCBI36
Build 342220,447,885 - 20,546,524NCBI
Celera225,931,476 - 6,039,519 (-)NCBI
Cytogenetic Map22q11.22NCBI
HuRef225,071,209 - 5,179,617 (-)NCBIHuRef
CHM1_12222,114,127 - 22,222,150 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model