RGD Reference Report - The expression of ER, PR in endometrial cancer and analysis of their correlation with ERK signaling pathway. - Rat Genome Database

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The expression of ER, PR in endometrial cancer and analysis of their correlation with ERK signaling pathway.

Authors: Luo, Lan  Xu, Lina  Tang, Liang 
Citation: Luo L, etal., Cancer Biomark. 2017 Dec 12;21(1):145-149. doi: 10.3233/CBM-170457.
RGD ID: 13702082
Pubmed: PMID:29081408   (View Abstract at PubMed)
DOI: DOI:10.3233/CBM-170457   (Journal Full-text)

Endometrial carcinoma (EC) is a common malignant tumor in gynecology. Its incidence and development are closely associated with the levels of estrogenic and progesterone hormone. Extracellular signal-regulated kinase (ERK) signaling pathway abnormity is associated with a variety of tumors. This study detected estrogen receptor (ER), progesterone receptor (PR), ERK1, and ERK2 expression in EC and analyzed their correlations. A total of 40 EC patients in our hospital were selected as test group, while another 40 healthy volunteers were enrolled as control group. ER, PR, ERK1, and ERK2 expression in EC tissue, para-carcinoma tissue, and normal endometrial tissue were detected by immunohistochemistry and Western blot. The positive rate of ER, PR, ERK1, and ERK2 in the test group was 50%, 40%, 60%, and 65%, respectively, which were significantly higher than those in the control (P< 0.05). ER, PR, ERK1, and ERK2 protein expressions in EC cell were significantly higher than those in the control (P< 0.05). ERK1 and ERK2 presented positive correlation with ER and PR (P< 0.05). In conclusion, EC patients presented higher expressions of ER, PR, which were correlated with higher levels of ERK1 and ERK2, suggesting they might be involved in the pathogenesis of EC.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
endometrial carcinoma  IEP 13702082; 13702082protein:increased expression:endometrium (human)RGD 
endometrial carcinoma  ISOMAPK1 (Homo sapiens)13702082; 13702082protein:increased expression:endometrium (human)RGD 
endometrial carcinoma  ISOMAPK3 (Homo sapiens)13702082; 13702082protein:increased expression:endometrium (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mapk1  (mitogen activated protein kinase 1)
Mapk3  (mitogen activated protein kinase 3)

Genes (Mus musculus)
Mapk1  (mitogen-activated protein kinase 1)
Mapk3  (mitogen-activated protein kinase 3)

Genes (Homo sapiens)
MAPK1  (mitogen-activated protein kinase 1)
MAPK3  (mitogen-activated protein kinase 3)


Additional Information