Mapk3 (mitogen-activated protein kinase 3) - Rat Genome Database

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Gene: Mapk3 (mitogen-activated protein kinase 3) Chinchilla lanigera
Analyze
Symbol: Mapk3
Name: mitogen-activated protein kinase 3
RGD ID: 8952907
Description: ENCODES a protein that exhibits ATP binding (ortholog); DNA-binding transcription factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); arachidonate metabolic process (ortholog); Bergmann glial cell differentiation (ortholog); PARTICIPATES IN ceramide signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); alcohol dependence (ortholog); alcohol use disorder (ortholog); FOUND IN caveola (ortholog); ciliary basal body (ortholog); cilium (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,869,668 - 6,879,152 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,870,699 - 6,876,836 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
alcohol dependence  (ISO)
alcohol use disorder  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
Atrophy  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
brain ischemia  (ISO)
cardiomyopathy  (ISO)
chromosome 16p11.2 deletion syndrome, 220-kb  (ISO)
chromosome 16p11.2 deletion syndrome, 593-kb  (ISO)
chromosome 16p11.2 duplication syndrome  (ISO)
cocaine abuse  (ISO)
cocaine dependence  (ISO)
Cocaine-Related Disorders  (ISO)
colon adenocarcinoma  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Coronavirus infectious disease  (ISO)
coronin-1A deficiency  (ISO)
Developmental Disabilities  (ISO)
Diabetic Cardiomyopathies  (ISO)
dilated cardiomyopathy  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
Episodic Kinesigenic Dyskinesia  (ISO)
episodic kinesigenic dyskinesia 1  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
extrahepatic cholestasis  (ISO)
Female Infertility  (ISO)
gastric ulcer  (ISO)
Gliosis  (ISO)
Glycogen Storage Disease XII  (ISO)
Head and Neck Neoplasms  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (ISO)
Hypertrophy  (ISO)
Insulin Resistance  (ISO)
Kidney Neoplasms  (ISO)
Lung Neoplasms  (ISO)
Memory Disorders  (ISO)
middle cerebral artery infarction  (ISO)
morphine dependence  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
Neurodevelopmental Disorders  (ISO)
neuronal ceroid lipofuscinosis 6A  (ISO)
obesity  (ISO)
Osteoarthritis, Experimental  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
Pneumococcal Pneumonia  (ISO)
Postoperative Cognitive Dysfunction  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Shock  (ISO)
spondylocostal dysostosis 5  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Testis Reperfusion Injury  (ISO)
trigeminal neuralgia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
arachidonate metabolic process  (ISO)
Bergmann glial cell differentiation  (ISO)
BMP signaling pathway  (ISO)
cardiac neural crest cell development involved in heart development  (ISO)
cartilage development  (ISO)
cellular response to amino acid starvation  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to toxic substance  (ISO)
cellular response to tumor necrosis factor  (ISO)
decidualization  (ISO)
DNA damage response  (ISO)
DNA-templated transcription  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
ERBB2-ERBB3 signaling pathway  (ISO)
ERK1 and ERK2 cascade  (ISO)
face development  (ISO)
insulin receptor signaling pathway  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
interleukin-1-mediated signaling pathway  (ISO)
interleukin-34-mediated signaling pathway  (ISO)
intracellular signal transduction  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
lung morphogenesis  (ISO)
MAPK cascade  (ISO)
modulation of chemical synaptic transmission  (ISO)
myelination  (ISO)
negative regulation of T cell mediated immune response to tumor cell  (ISO)
negative regulation of TORC1 signaling  (ISO)
neural crest cell development  (ISO)
obsolete negative regulation of apolipoprotein binding  (ISO)
outer ear morphogenesis  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-tyrosine autophosphorylation  (ISO)
phosphorylation  (ISO)
positive regulation of cyclase activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of macrophage proliferation  (ISO)
positive regulation of telomere maintenance  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of translation  (ISO)
positive regulation of xenophagy  (ISO)
protein phosphorylation  (ISO)
protein-containing complex assembly  (ISO)
regulation of cellular pH  (ISO)
regulation of DNA-binding transcription factor activity  (ISO)
regulation of ossification  (ISO)
response to epidermal growth factor  (ISO)
response to exogenous dsRNA  (ISO)
response to lipopolysaccharide  (ISO)
response to toxic substance  (ISO)
Schwann cell development  (ISO)
sensory perception of pain  (ISO)
signal transduction in response to DNA damage  (ISO)
stress-activated MAPK cascade  (ISO)
thymus development  (ISO)
thyroid gland development  (ISO)
trachea formation  (ISO)
xenophagy  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mapk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,869,668 - 6,879,152 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,870,699 - 6,876,836 (+)NCBIChiLan1.0ChiLan1.0
MAPK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,114,105 - 30,123,220 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,114,105 - 30,123,506 (-)EnsemblGRCh38hg38GRCh38
GRCh371630,125,426 - 30,134,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,032,927 - 30,042,131 (-)NCBINCBI36Build 36hg18NCBI36
Build 341630,032,927 - 30,042,039NCBI
Celera1672,661,419 - 72,670,625 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,786,557 - 27,795,763 (-)NCBIHuRef
CHM1_11631,341,181 - 31,350,385 (-)NCBICHM1_1
T2T-CHM13v2.01630,396,752 - 30,405,867 (-)NCBIT2T-CHM13v2.0
Mapk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,358,798 - 126,364,988 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,358,773 - 126,364,991 (+)EnsemblGRCm39 Ensembl
GRCm387126,759,626 - 126,765,816 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,759,601 - 126,765,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv377133,903,140 - 133,909,330 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,550,780 - 126,556,964 (+)NCBIMGSCv36mm8
Celera7126,607,166 - 126,613,154 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.25NCBI
Mapk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,797,189 - 190,803,411 (+)NCBIGRCr8
mRatBN7.21181,366,646 - 181,372,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,366,637 - 181,372,863 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,717,952 - 189,724,168 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,904,026 - 196,910,242 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,571,369 - 189,577,596 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,192,773 - 198,198,975 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,192,773 - 198,198,975 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,172,641 - 205,178,843 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,935,044 - 185,941,245 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,084,924 - 186,091,127 (+)NCBI
Celera1179,022,318 - 179,028,386 (+)NCBICelera
Cytogenetic Map1q36NCBI
MAPK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21830,864,038 - 30,873,180 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11635,352,686 - 35,361,831 (+)NCBINHGRI_mPanPan1
PanPan1.11630,489,362 - 30,498,026 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,489,362 - 30,498,017 (-)Ensemblpanpan1.1panPan2
MAPK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,109,184 - 18,115,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,109,222 - 18,114,425 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,687,831 - 19,694,273 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,245,190 - 18,251,639 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,245,190 - 18,251,639 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,044,145 - 18,050,587 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,959,533 - 17,965,981 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,275,160 - 18,281,602 (-)NCBIUU_Cfam_GSD_1.0
Mapk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,287,605 - 124,292,797 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,384,804 - 12,392,180 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,342,670 - 12,390,650 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,291,445 - 18,299,567 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,291,444 - 18,299,410 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAPK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,536,471 - 26,545,666 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,536,532 - 26,546,461 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660682,993,354 - 3,002,555 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,152,039 - 13,159,113 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,150,824 - 13,158,327 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000019314   ⟹   ENSCLAP00000019129
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554936,869,668 - 6,875,428 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000019315   ⟹   ENSCLAP00000019130
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554936,870,699 - 6,879,152 (+)Ensembl
RefSeq Acc Id: XM_013504886   ⟹   XP_013360340
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554936,870,699 - 6,876,836 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013360340 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000019129.1
  ENSCLAP00000019130
  ENSCLAP00000019130.1
RefSeq Acc Id: XP_013360340   ⟸   XM_013504886
- UniProtKB: A0A8C2VQE2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000019129   ⟸   ENSCLAT00000019314
Ensembl Acc Id: ENSCLAP00000019130   ⟸   ENSCLAT00000019315
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000013110 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000019314.1 UniProtKB/TrEMBL
  ENSCLAT00000019315 ENTREZGENE
  ENSCLAT00000019315.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  MAPK_ERK1/2 UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Mapk3 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PRINTS ERK1ERK2MAPK UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2VQE2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VVS4_CHILA UniProtKB/TrEMBL