MAPK3 (mitogen-activated protein kinase 3) - Rat Genome Database

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Gene: MAPK3 (mitogen-activated protein kinase 3) Canis lupus familiaris
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Symbol: MAPK3
Name: mitogen-activated protein kinase 3
RGD ID: 12388002
Description: ENCODES a protein that exhibits ATP binding (ortholog); DNA-binding transcription factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); arachidonic acid metabolic process (ortholog); Bergmann glial cell differentiation (ortholog); PARTICIPATES IN ceramide signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); alcohol dependence (ortholog); alcohol use disorder (ortholog); FOUND IN cytosol (ortholog); glutamatergic synapse (ortholog); nuclear envelope (ortholog); INTERACTS WITH arsane; arsenic atom; arsenous acid
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC102154403   LOC486758  
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,109,184 - 18,115,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,109,222 - 18,114,425 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,687,831 - 19,694,273 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,245,190 - 18,251,639 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,245,190 - 18,251,639 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,044,145 - 18,050,587 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,959,533 - 17,965,981 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,275,160 - 18,281,602 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
alcohol dependence  (ISO)
alcohol use disorder  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
Atrophy  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
brain ischemia  (ISO)
cardiomyopathy  (ISO)
chromosome 16p11.2 deletion syndrome, 593-kb  (ISO)
chromosome 16p11.2 duplication syndrome  (ISO)
cocaine abuse  (ISO)
cocaine dependence  (ISO)
Cocaine-Related Disorders  (ISO)
colon adenocarcinoma  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Coronavirus infectious disease  (ISO)
coronin-1A deficiency  (ISO)
Developmental Disabilities  (ISO)
Diabetic Cardiomyopathies  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
episodic kinesigenic dyskinesia 1  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
extrahepatic cholestasis  (ISO)
Female Infertility  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
Gliosis  (ISO)
Glycogen Storage Disease XII  (ISO)
Head and Neck Neoplasms  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (ISO)
Hypertrophy  (ISO)
Insulin Resistance  (ISO)
Kidney Neoplasms  (ISO)
Lung Neoplasms  (ISO)
Memory Disorders  (ISO)
middle cerebral artery infarction  (ISO)
morphine dependence  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
Neurodevelopmental Disorders  (ISO)
neuronal ceroid lipofuscinosis 6A  (ISO)
obesity  (ISO)
Osteoarthritis, Experimental  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
Pneumococcal Pneumonia  (ISO)
Postoperative Cognitive Dysfunction  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Shock  (ISO)
spondylocostal dysostosis 5  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Testis Reperfusion Injury  (ISO)
trigeminal neuralgia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
arachidonic acid metabolic process  (ISO)
Bergmann glial cell differentiation  (ISO)
BMP signaling pathway  (ISO)
cardiac neural crest cell development involved in heart development  (ISO)
cartilage development  (ISO)
caveolin-mediated endocytosis  (IEA)
cellular response to amino acid starvation  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to tumor necrosis factor  (ISO)
decidualization  (ISO)
DNA damage response  (ISO)
DNA-templated transcription  (ISO)
ERBB2-ERBB3 signaling pathway  (ISO)
ERK1 and ERK2 cascade  (ISO)
face development  (ISO)
insulin receptor signaling pathway  (ISO)
insulin-like growth factor receptor signaling pathway  (ISO)
interleukin-1-mediated signaling pathway  (ISO)
intracellular signal transduction  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
lung morphogenesis  (ISO)
MAPK cascade  (IEA,ISO)
modulation of chemical synaptic transmission  (ISO)
myelination  (ISO)
negative regulation of TORC1 signaling  (ISO)
neural crest cell development  (ISO)
outer ear morphogenesis  (ISO)
peptidyl-serine phosphorylation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of macrophage proliferation  (ISO)
positive regulation of telomere capping  (ISO)
positive regulation of telomere maintenance via telomerase  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of translation  (ISO)
positive regulation of xenophagy  (ISO)
protein phosphorylation  (ISO)
protein-containing complex assembly  (ISO)
regulation of cellular pH  (ISO)
regulation of cytoskeleton organization  (IEA)
regulation of early endosome to late endosome transport  (IEA)
regulation of Golgi inheritance  (IEA)
regulation of ossification  (ISO)
regulation of stress-activated MAPK cascade  (IEA)
response to epidermal growth factor  (ISO)
response to exogenous dsRNA  (ISO)
response to lipopolysaccharide  (ISO)
response to toxic substance  (ISO)
Schwann cell development  (ISO)
sensory perception of pain  (ISO)
signal transduction in response to DNA damage  (ISO)
stress-activated MAPK cascade  (ISO)
thymus development  (ISO)
thyroid gland development  (ISO)
trachea formation  (ISO)
xenophagy  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:24146543   PMID:24557342   PMID:25770213   PMID:30032202  


Genomics

Comparative Map Data
MAPK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,109,184 - 18,115,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,109,222 - 18,114,425 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,687,831 - 19,694,273 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,245,190 - 18,251,639 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,245,190 - 18,251,639 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,044,145 - 18,050,587 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,959,533 - 17,965,981 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,275,160 - 18,281,602 (-)NCBIUU_Cfam_GSD_1.0
MAPK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,114,105 - 30,123,220 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,114,105 - 30,123,506 (-)EnsemblGRCh38hg38GRCh38
GRCh371630,125,426 - 30,134,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,032,927 - 30,042,131 (-)NCBINCBI36Build 36hg18NCBI36
Build 341630,032,927 - 30,042,039NCBI
Celera1672,661,419 - 72,670,625 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1627,786,557 - 27,795,763 (-)NCBIHuRef
CHM1_11631,341,181 - 31,350,385 (-)NCBICHM1_1
T2T-CHM13v2.01630,396,752 - 30,405,867 (-)NCBIT2T-CHM13v2.0
Mapk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,358,798 - 126,364,988 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,358,773 - 126,364,991 (+)EnsemblGRCm39 Ensembl
GRCm387126,759,626 - 126,765,816 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,759,601 - 126,765,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv377133,903,140 - 133,909,330 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,550,780 - 126,556,964 (+)NCBIMGSCv36mm8
Celera7126,607,166 - 126,613,154 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.25NCBI
Mapk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,797,189 - 190,803,411 (+)NCBIGRCr8
mRatBN7.21181,366,646 - 181,372,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,366,637 - 181,372,863 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,717,952 - 189,724,168 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,904,026 - 196,910,242 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,571,369 - 189,577,596 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01198,192,773 - 198,198,975 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,192,773 - 198,198,975 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,172,641 - 205,178,843 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,935,044 - 185,941,245 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,084,924 - 186,091,127 (+)NCBI
Celera1179,022,318 - 179,028,386 (+)NCBICelera
Cytogenetic Map1q36NCBI
Mapk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,869,668 - 6,879,152 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,870,699 - 6,876,836 (+)NCBIChiLan1.0ChiLan1.0
MAPK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21830,864,038 - 30,873,180 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11635,352,686 - 35,361,831 (+)NCBINHGRI_mPanPan1
PanPan1.11630,489,362 - 30,498,026 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,489,362 - 30,498,017 (-)Ensemblpanpan1.1panPan2
Mapk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,287,605 - 124,292,797 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650112,384,804 - 12,392,180 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650112,342,670 - 12,390,650 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,291,445 - 18,299,567 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,291,444 - 18,299,410 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAPK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,536,471 - 26,545,666 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,536,532 - 26,546,461 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660682,993,354 - 3,002,555 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,152,039 - 13,159,113 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,150,824 - 13,158,327 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAPK3
61 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 7 6 25 7 5 4 20 15 8
Low 1 4 18 11 4 11 4 8 4 12 5 3
Below cutoff 2 1 1 1 1 3 4 1

Sequence


RefSeq Acc Id: ENSCAFT00000027090   ⟹   ENSCAFP00000025190
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl618,109,222 - 18,114,425 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845003526   ⟹   ENSCAFP00845002799
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl618,245,190 - 18,251,639 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845003533   ⟹   ENSCAFP00845002805
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl618,245,190 - 18,251,639 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845003544   ⟹   ENSCAFP00845002814
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl618,246,770 - 18,251,639 (-)Ensembl
RefSeq Acc Id: NM_001252035   ⟹   NP_001238964
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1618,109,184 - 18,115,728 (-)NCBI
Dog10K_Boxer_Tasha619,687,831 - 19,694,273 (-)NCBI
ROS_Cfam_1.0618,245,190 - 18,251,639 (-)NCBI
UMICH_Zoey_3.1618,044,145 - 18,050,587 (-)NCBI
UNSW_CanFamBas_1.0617,959,533 - 17,965,981 (-)NCBI
UU_Cfam_GSD_1.0618,275,160 - 18,281,602 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001238964   ⟸   NM_001252035
- UniProtKB: A0A8C0RUD1 (UniProtKB/TrEMBL),   A0A8C0KYY7 (UniProtKB/TrEMBL),   A0A8C0KZV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000025190   ⟸   ENSCAFT00000027090
RefSeq Acc Id: ENSCAFP00845002799   ⟸   ENSCAFT00845003526
RefSeq Acc Id: ENSCAFP00845002814   ⟸   ENSCAFT00845003544
RefSeq Acc Id: ENSCAFP00845002805   ⟸   ENSCAFT00845003533
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017108 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030000929 UniProtKB/TrEMBL
  ENSCAFG00040000216 UniProtKB/TrEMBL
  ENSCAFG00845002016 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000027090.5 UniProtKB/TrEMBL
  ENSCAFT00000106416.1 UniProtKB/TrEMBL
  ENSCAFT00000107510.1 UniProtKB/TrEMBL
  ENSCAFT00030001612.1 UniProtKB/TrEMBL
  ENSCAFT00030001627.1 UniProtKB/TrEMBL
  ENSCAFT00030001640.1 UniProtKB/TrEMBL
  ENSCAFT00040000373.1 UniProtKB/TrEMBL
  ENSCAFT00040000387.1 UniProtKB/TrEMBL
  ENSCAFT00040000388.1 UniProtKB/TrEMBL
  ENSCAFT00845003526 ENTREZGENE
  ENSCAFT00845003526.1 UniProtKB/TrEMBL
  ENSCAFT00845003533.1 UniProtKB/TrEMBL
  ENSCAFT00845003544.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  MAPK_ERK1/2 UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report cfa:100855877 UniProtKB/TrEMBL
NCBI Gene MAPK3 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 3 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PRINTS ERK1ERK2MAPK UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0KYY7 ENTREZGENE
  A0A8C0KZV9 ENTREZGENE
  A0A8C0LYL1_CANLF UniProtKB/TrEMBL
  A0A8C0PWQ3_CANLF UniProtKB/TrEMBL
  A0A8C0RUD1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MJZ4_CANLF UniProtKB/TrEMBL
  A0A8I3N0N1_CANLF UniProtKB/TrEMBL
  A0A8I3RQD0_CANLF UniProtKB/TrEMBL
  A0A8P0TIR5_CANLF UniProtKB/TrEMBL