RGD Reference Report - ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas.

Authors: Ku, Min-Chi  Edes, Inan  Bendix, Ivo  Pohlmann, Andreas  Waiczies, Helmar  Prozorovski, Tim  Günther, Martin  Martin, Conrad  Pagès, Gilles  Wolf, Susanne A  Kettenmann, Helmut  Uckert, Wolfgang  Niendorf, Thoralf  Waiczies, Sonia 
Citation: Ku MC, etal., Mol Cancer Ther. 2016 Aug;15(8):1975-87. doi: 10.1158/1535-7163.MCT-15-0850. Epub 2016 Jun 2.
RGD ID: 13702865
Pubmed: PMID:27256374   (View Abstract at PubMed)
DOI: DOI:10.1158/1535-7163.MCT-15-0850   (Journal Full-text)

Glioma regression requires the recruitment of potent antitumor immune cells into the tumor microenvironment. Dendritic cells (DC) play a role in immune responses to these tumors. The fact that DC vaccines do not effectively combat high-grade gliomas, however, suggests that DCs need to be genetically modified specifically to promote their migration to tumor relevant sites. Previously, we identified extracellular signal-regulated kinase (ERK1) as a regulator of DC immunogenicity and brain autoimmunity. In the current study, we made use of modern magnetic resonance methods to study the role of ERK1 in regulating DC migration and tumor progression in a model of high-grade glioma. We found that ERK1-deficient mice are more resistant to the development of gliomas, and tumor growth in these mice is accompanied by a higher infiltration of leukocytes. ERK1-deficient DCs exhibit an increase in migration that is associated with sustained Cdc42 activation and increased expression of actin-associated cytoskeleton-organizing proteins. We also demonstrated that ERK1 deletion potentiates DC vaccination and provides a survival advantage in high-grade gliomas. Considering the therapeutic significance of these results, we propose ERK1-deleted DC vaccines as an additional means of eradicating resilient tumor cells and preventing tumor recurrence. Mol Cancer Ther; 15(8); 1975-87. ©2016 AACR.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
MAPK3Humanhigh grade glioma  ISOMapk3 (Mus musculus) RGD 
Mapk3Rathigh grade glioma  ISOMapk3 (Mus musculus) RGD 
Mapk3Mousehigh grade glioma  IMP  RGD 


Genes (Rattus norvegicus)
Mapk3  (mitogen activated protein kinase 3)

Genes (Mus musculus)
Mapk3  (mitogen-activated protein kinase 3)

Genes (Homo sapiens)
MAPK3  (mitogen-activated protein kinase 3)