ALDOSTERONE SIGNALING PATHWAY (PW:0000568)

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Description

Aldosterone signaling plays a major role in the control of blood pressure by regulating sodium reabsorption in the kidney via expression of its target genes. Aldosterone is a steroid hormone that engages the aldosterone receptor, also known as the mineralocorticoid receptor - a member of the nuclear receptor family that belongs to subfamily 3 (Nr3c2). A unique feature of this receptor is that, in addition to aldosterone, it can be bound by different steroid hormones such as other mineralocortico

Pathway Diagram:

Ariadne Genomics Inc. Hsd11b2 ---| Nr3c2 cortisol ---- Nr3c2 cortisone cortisol aldosterone aldosterone biosynthetic pathway steroid hormone biosynthetic pathway Nr3c2 target genes Hsd11b2 Nr3c2 ---> translocated Nr3c2 complex translocated Nr3c2 complex Nr3c2 aldosterone ---- Nr3c2 cortisol ---> cortisone Nr3c2 ---- Nr3c2 chaperones Nr3c2 corepressors ---- translocated Nr3c2 complex Nr3c2 coactivators ---- translocated Nr3c2 complex Nr3c2 coactivators --+> translocated Nr3c2 complex Nr3c2 corepressors ---| translocated Nr3c2 complex translocated Nr3c2 complex ---> Nr3c2 target genes Nr3c2 chaperones Nr3c2 corepressors Nr3c2 coactivators
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Genes in Pathway:

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aldosterone signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 JBrowse link 2 204,003,742 204,032,023 RGD:6907045
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 JBrowse link 13 90,651,682 90,676,629 RGD:6907045
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 JBrowse link 1 81,852,423 81,881,565 RGD:6907045
G Atp1a4 ATPase Na+/K+ transporting subunit alpha 4 JBrowse link 13 90,605,792 90,642,032 RGD:6907045
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 JBrowse link 13 82,737,161 82,757,681 RGD:6907045
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 JBrowse link 10 56,205,622 56,211,879 RGD:6907045
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 JBrowse link 8 104,190,032 104,221,342 RGD:6907045
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 JBrowse link X 124,631,544 124,652,520 RGD:6907045
G Casp8ap2 caspase 8 associated protein 2 JBrowse link 5 47,853,699 47,891,147 RGD:7421504
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:7421504
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:7421504
G Dhx9 DExH-box helicase 9 JBrowse link 13 70,885,503 70,922,278 RGD:7421504
G Ell elongation factor for RNA polymerase II JBrowse link 16 20,594,129 20,641,441 RGD:7421504
G Faf1 Fas associated factor 1 JBrowse link 5 129,370,767 129,738,393 RGD:7421504
G Fkbp4 FK506 binding protein 4 JBrowse link 4 161,748,993 161,757,447 RGD:7421504
G Fkbp5 FK506 binding protein 5 JBrowse link 20 7,976,704 8,097,290 RGD:7421504
G Fxyd2 FXYD domain-containing ion transport regulator 2 JBrowse link 8 49,710,334 49,717,492 RGD:6907045
G Fxyd4 FXYD domain-containing ion transport regulator 4 JBrowse link 4 149,984,206 149,988,744 RGD:6907045
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 JBrowse link 13 111,946,626 111,996,536 RGD:6907045
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 JBrowse link 19 37,476,083 37,481,326 RGD:6907045
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:7421504
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:7421504
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6907045
G Ins1 insulin 1 JBrowse link 1 272,799,784 272,800,351 RGD:6907045
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6907045
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:6907045
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:6907045
G Irs2 insulin receptor substrate 2 JBrowse link 16 83,824,515 83,848,569 RGD:6907045
G Irs3 insulin receptor substrate 3 JBrowse link 12 22,120,305 22,125,103 RGD:6907045
G Irs4 insulin receptor substrate 4 JBrowse link X 113,003,824 113,018,088 RGD:6907045
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1641841
G Kcnj1 potassium voltage-gated channel subfamily J member 1 JBrowse link 8 33,490,280 33,519,127 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Ncoa1 nuclear receptor coactivator 1 JBrowse link 6 28,677,563 28,931,844 RGD:7421504
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:7421504
G Ncor1 nuclear receptor co-repressor 1 JBrowse link 10 48,629,121 48,772,890 RGD:7421504
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:7421504
G Nedd4l neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase JBrowse link 18 60,392,376 60,719,720 RGD:6907045
G Nfyc nuclear transcription factor Y subunit gamma JBrowse link 5 139,687,442 139,760,154 RGD:7421504
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 JBrowse link 19 34,408,275 34,761,003 RGD:6907045
RGD:7421504
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6907045
G Pias1 protein inhibitor of activated STAT, 1 JBrowse link 8 67,771,720 67,869,015 RGD:7421504
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:7421504
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6907045
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6907045
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6907045
G Ptges3 prostaglandin E synthase 3 JBrowse link 7 2,479,267 2,497,024 RGD:7421504
G Scnn1a sodium channel epithelial 1 alpha subunit JBrowse link 4 157,834,339 157,860,472 RGD:6907045
G Scnn1b sodium channel epithelial 1 beta subunit JBrowse link 1 191,829,547 191,883,991 RGD:6907045
G Scnn1g sodium channel epithelial 1 gamma subunit JBrowse link 1 191,704,397 191,738,271 RGD:6907045
G Sfn stratifin JBrowse link 5 151,823,422 151,824,937 RGD:6907045
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 1 24,185,451 24,302,309 RGD:6907045
G Slc9a3r2 SLC9A3 regulator 2 JBrowse link 10 14,003,330 14,015,066 RGD:6907045
G Ube2i ubiquitin-conjugating enzyme E2I JBrowse link 10 14,618,615 14,639,274 RGD:7421504

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassNr3c2 chaperonesaldosterone receptor chaperones
Functional ClassNr3c2 coactivatorsaldosterone receptor coactivators
Functional ClassNr3c2 corepressorsaldosterone receptor corepressors
Gene GroupNr3c2 target genesaldosterone receptor target genes

Pathway Gene Annotations

Disease Annotations Associated with Genes in the aldosterone signaling pathway
Disease TermsGene Symbols
Abdominal ObesityHsd11b1
abdominal obesity-metabolic syndromePpargc1a
Aberrant Crypt FociMapk1 , Mapk3
Abortion, SpontaneousIgf1 , Jak2
acneIgf1
acoustic neuromaIgf1
acromegalyIgf1
acute kidney failureIgf1 , Ins2 , Ppargc1a
Acute Liver FailureIns1 , Ins2
Acute Lymphoblastic Leukemia, with Lymphomatous FeaturesJak2
acute myeloid leukemiaAtp1b1 , Crebbp , Jak2 , Kras , Ncoa2 , Sgk1
Acute-Phase ReactionNcor1
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaKras , Pik3ca
adenoid cystic carcinomaCrebbp , Kras , Pik3ca
adenomaAtp1a1 , Igf1 , Ins2 , Kras
adrenal carcinomaPik3ca
adrenal cortical adenomaAtp1a1
Adrenal InsufficiencyScnn1b
adrenocortical carcinomaDaxx , Pik3ca
adult T-cell leukemiaPrkcb
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AIDS Dementia ComplexInsr , Irs1
AlbuminuriaIgf1 , Ins2 , Ppargc1a
alcoholic liver cirrhosisJak2
alcoholic neuropathyIgf1
allergic contact dermatitisHsd11b1
alopeciaIgf1
alternating hemiplegia of childhoodAtp1a2 , Atp1a3
Alternating Hemiplegia of Childhood 2Atp1a3
Alzheimer's diseaseCrebbp , Hsp90aa1 , Igf1 , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Jak2 , Pik3r1 , Ppargc1a
amblyopiaPpargc1a
amyotrophic lateral sclerosisPpargc1a
amyotrophic lateral sclerosis type 1Crebbp
anaplastic large cell lymphomaHsp90aa1
androgen insensitivity syndromeFkbp4
anemiaJak2 , Kras
angiosarcomaKras
Animal Disease ModelsKras , Mapk1 , Mapk3 , Prkcg
ankylosing spondylitisJak2
anthracosisAtp1a4
anxiety disorderNcor1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
apparent mineralocorticoid excessHsd11b2
apparent mineralocorticoid excess syndromeHsd11b2
Arsenic PoisoningPias1
arteriosclerosisIgf1
arteriovenous malformations of the brainKras
asthmaHsd11b2
Asthma, OccupationalPrkca
astrocytomaKras
ataxia with oculomotor apraxia type 3Pik3r5
atherosclerosisPtges3
AtrophyMapk3
attention deficit hyperactivity disorderCrebbp
autism spectrum disorderMapk3
autistic disorderCrebbp , Igf1 , Mapk1 , Prkcb
autoimmune lymphoproliferative syndrome type 4Kras
autosomal dominant pseudohypoaldosteronism type 1Nr3c2
autosomal recessive limb-girdle muscular dystrophy type 2NInsr
autosomal recessive polycystic kidney diseasePik3ca
autosomal recessive pseudohypoaldosteronism type 1Scnn1a , Scnn1b , Scnn1g
Bannayan-Riley-Ruvalcaba syndromePik3ca
Bartter diseaseKcnj1
Bartter disease type 2Kcnj1
basal cell carcinomaPik3ca
benign neonatal seizuresAtp1a2
bipolar disorderAtp1a3 , Ins2
bladder diseaseIns2
bladder urothelial carcinomaCrebbp , Kras , Pik3ca
Bowen's DiseasePpargc1a
Brain InjuriesIgf1 , Jak2 , Pias1 , Ppargc1a
brain ischemiaIgf1 , Mapk1 , Mapk3 , Prkca
Brain NeoplasmsPik3ca , Pik3r1
breast adenocarcinomaKras , Pik3ca
breast cancerKras , Pik3ca
Breast Cancer, FamilialNcor1 , Pik3r3
Breast NeoplasmsHsp90aa1 , Igf1 , Insr , Kras , Mapk1 , Ncoa1 , Ncoa2 , Ncor1 , Ncor2 , Pdpk1 , Pik3ca , Pik3r1 , Prkca , Ptges3
bronchiectasisScnn1a , Scnn1b , Scnn1g
Bronchiectasis with or without Elevated Sweat Chloride 1Scnn1a , Scnn1b , Scnn1g
Bronchiectasis with or without Elevated Sweat Chloride 2Scnn1a , Scnn1b , Scnn1g
Bronchiectasis with or without Elevated Sweat Chloride 3Scnn1a , Scnn1b , Scnn1g
bronchiolo-alveolar adenocarcinomaKras
Bruton-type agammaglobulinemiaPik3r1
Budd-Chiari syndromeJak2
Burkitt lymphomaPik3r1
BurnsIgf1
calcinosisJak2
CAPOS SyndromeAtp1a3
CarcinogenesisKras
carcinomaKras , Pik3r1 , Sgk1 , Ube2i
cardiac arrestIns2
Cardiac ArrhythmiasAtp1b1
cardiofaciocutaneous syndromeKras
Cardiofaciocutaneous Syndrome 2Kras
CardiomegalyAtp1a2 , Igf1 , Mapk1 , Ppargc1a , Prkca , Prkcb
cardiomyopathyInsr , Kras , Mapk1 , Mapk3 , Ppargc1a
Cardiomyopathy, Hypertrophic, FamilialKras
cardiovascular system diseasePpargc1a
carotid artery diseaseIgf1
Carotid Artery InjuriesIgf1 , Ppargc1a
Cecal NeoplasmsKras
Cell Transformation, NeoplasticIrs1 , Kras
central nervous system diseaseCrebbp
Chemical and Drug Induced Liver InjuryIgf1
cholangiocarcinomaKras
cholestasisIgf1
choriocarcinomaInsr
chronic kidney diseaseInsr , Ppargc1a
chronic lymphocytic leukemiaKras
Chronic Lymphocytic Leukemia, B-CellKras
chronic myeloid leukemiaJak2
chronic obstructive pulmonary diseasePpargc1a
Chuvash polycythemiaJak2
clear cell adenocarcinomaDaxx
cleft palateNedd4l
Cocaine-Related DisordersMapk1 , Mapk3
Cockayne syndromeIgf1
cognitive disorderIns2
Cognitive DysfunctionHsp90aa1
colitisIgf1 , Ppargc1a
colon adenocarcinomaDaxx , Mapk1 , Mapk3 , Pik3r3
colon cancerPik3ca
colon carcinomaPik3ca
Colonic NeoplasmsKras , Pik3ca , Pik3r1 , Pik3r2 , Pik3r5
colorectal adenocarcinomaMapk1 , Mapk3
colorectal cancerPik3ca
Colorectal NeoplasmsCrebbp , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Prkcb
complex cortical dysplasia with other brain malformationsPik3ca
congenital diaphragmatic herniaIgf1
Congenital Disorder of Glycosylation Type 1AIgf1
congenital hypothyroidismIgf1 , Ppargc1a
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
congestive heart failureAtp1a3 , Igf1 , Ins2 , Nr3c2 , Pdpk1 , Ppargc1a , Prkca , Prkcb
contact dermatitisHsp90aa1
corneal diseaseIgf1
coronary artery diseaseIrs1
Coronary DiseaseIgf1 , Irs1
coronary restenosisMapk1
coronary stenosisIgf1
coronin-1A deficiencyMapk3
cortisone reductase deficiencyHsd11b1
cortisone reductase deficiency 2Hsd11b1
Costello syndromeKras
Cowden diseasePik3ca
Cowden Syndrome 5Pik3ca
Cowden-Like SyndromePik3ca
Crohn's diseaseIgf1 , Jak2
Currarino TriadPik3ca
Cutaneous Malignant Melanoma, Susceptibility To, 1Atp1a2 , Atp1b1 , Pik3ca
Cystadenoma, SerousDaxx
cystic fibrosisIgf1 , Scnn1a , Scnn1b , Scnn1g
cystic kidney diseaseIns2
Danon diseaseAtp1b4
DeafnessIgf1
demyelinating diseaseIgf1
Developmental DisabilitiesAtp1a3 , Ncor1 , Pik3r2
diabetes mellitusIgf1 , Ins1 , Ins2 , Insr , Irs1
Diabetes Mellitus, Insulin-Resistant, with Acanthosis NigricansInsr
Diabetic CardiomyopathiesIgf1 , Ins2
Diabetic FootIgf1
diabetic ketoacidosisIns2 , Insr
Diabetic NephropathiesIgf1 , Ins2 , Irs2 , Jak2 , Mapk1 , Ppargc1a , Prkcb
diabetic neuropathyIgf1 , Insr , Sgk1
diabetic retinopathyIgf1 , Ins2 , Ppargc1a
diffuse large B-cell lymphomaPdpk1 , Pik3ca , Pik3cb , Pik3cd
dilated cardiomyopathyIgf1 , Kras , Nedd4l , Nr3c2 , Ppargc1a , Prkca , Prkcb
disease of cellular proliferationKras , Pik3ca , Pik3r1
disease of metabolismIns2
Disease ProgressionPik3ca
Diseases of the AgedPpargc1a
Donohue syndromeInsr
Drug-Related Side Effects and Adverse ReactionsIgf1
ductal carcinoma in situPrkca
DwarfismIgf1
dystoniaAtp1a3 , Ins2
dystonia 12Atp1a3
EAST syndromeAtp1a2
EdemaIns2
end stage renal failureIgf1 , Irs1
endogenous depressionFkbp5
endometrial cancerPik3cb , Pik3r1
endometrial carcinomaKras , Pik3ca , Pik3r1
Endometrial HyperplasiaKras
Endometrial NeoplasmsKras , Mapk1 , Mapk3 , Ncoa1 , Ncor2 , Pik3ca , Pik3cb , Pik3cd , Prkca , Sfn
Endometrioid CarcinomasDaxx , Kras , Pik3r2
endometriosisFkbp5 , Igf1 , Kras , Ncoa1 , Ncor1 , Nedd4l , Nr3c2
EndotoxemiaIgf1 , Irs1
epidermal nevusKras , Pik3ca
epilepsyAtp1a3
esophageal carcinomaKras , Pik3ca
Esophageal NeoplasmsKras , Pik3ca , Sfn
esophagus adenocarcinomaPik3ca
esophagus squamous cell carcinomaAtp1b2 , Crebbp , Sfn
essential hypertensionAtp1b1
essential thrombocythemiaJak2
Experimental ArthritisIgf1 , Jak2 , Pik3cd , Ptges3
Experimental Autoimmune EncephalomyelitisIgf1 , Jak2
Experimental Diabetes MellitusHsd11b1 , Hsp90aa1 , Igf1 , Insr , Irs1 , Irs2 , Mapk1 , Mapk3 , Pik3r1 , Ppargc1a , Prkca , Prkcb
Experimental Liver CirrhosisFxyd2 , Igf1 , Ins2 , Jak2 , Ncor2 , Prkcb
Experimental NeoplasmsKras
Experimental SarcomaKras
extrahepatic cholestasisMapk1 , Mapk3
Facial AsymmetryPik3ca
Familial Basilar MigraineAtp1a2
familial erythrocytosis 1Jak2
familial hemiplegic migraineAtp1a2
Familial Hemiplegic Migraine, Type 2Atp1a2
familial hyperlipidemiaHsd11b1 , Irs1
familial Mediterranean feverIgf1 , Scnn1a
fatty liver diseaseIns2 , Jak2 , Ppargc1a
Female InfertilityHsp90ab1 , Mapk1 , Mapk3
Female Urogenital DiseasesIgf1
fetal alcohol spectrum disorderIgf1
Fetal DiseasesPrkcb
Fetal Growth RetardationHsd11b2 , Igf1 , Irs1 , Irs2 , Ppargc1a
Fetal MacrosomiaIgf1
focal segmental glomerulosclerosisPias1
folic acid deficiency anemiaIgf1
follicular lymphomaCrebbp
follicular thyroid carcinomaKras
Frontotemporal Lobar DegenerationHsp90aa1
Gallbladder NeoplasmsKras
gastric adenocarcinomaCrebbp , Kras , Pik3ca
Gastroenteritis, Transmissible, of SwineAtp1a1
Gastrointestinal NeoplasmsPik3ca
gastrointestinal stromal tumorKras
Generalized EpilepsyAtp1a2
genetic diseaseAtp1a2 , Atp1a3 , Crebbp , Kras , Mapk1 , Pik3ca , Pik3r1 , Pik3r2 , Prkcg , Scnn1b
Germ Cell and Embryonal NeoplasmsScnn1a
gestational diabetesIns2 , Insr
glaucomaCrebbp
glioblastoma multiformeCrebbp , Ncor1 , Pik3ca , Pik3r1
GliosisMapk1 , Mapk3
glomerulonephritisMapk1
glucose intoleranceIns2 , Insr , Jak2 , Ppargc1a
granulosa cell tumorSgk1
Graves OphthalmopathyIgf1
Graves' diseaseIgf1
Growth DisordersIgf1 , Jak2 , Pik3ca
Growth Restriction, Severe, with Distinctive FaciesIns1
Head and Neck NeoplasmsMapk1 , Mapk3 , Pik3ca
head and neck squamous cell carcinomaCrebbp , Mapk1 , Pik3ca
Head Injuries, ClosedIgf1
Hearing Loss, Noise-InducedIgf1
Hearing Loss, SuddenIgf1
heart diseaseJak2 , Ppargc1a
heart valve diseaseJak2
Heavy Metal ToxicityDaxx
HemimegalencephalyPik3ca
Henoch-Schoenlein purpuraIgf1
HepatitisIns2
hepatocellular adenomaKras
hepatocellular carcinomaCrebbp , Irs1 , Irs2 , Kras , Pik3ca , Sfn
Hereditary Neoplastic SyndromesPik3ca
Hernias, Diaphragmatic, CongenitalIgf1 , Insr
Hirschsprung Disease 1Crebbp
human immunodeficiency virus infectious diseaseHsp90aa1 , Hsp90ab1
Huntington's diseaseCrebbp , Igf1 , Ncor1 , Ppargc1a
HyperalgesiaIgf1 , Insr , Jak2 , Mapk1 , Mapk3 , Prkcb , Prkcg , Ptges3
Hyperbilirubinemia, NeonatalNcor1
hyperglycemiaHsd11b1 , Ins2 , Insr , Irs2 , Ppargc1a , Prkcb
hyperhomocysteinemiaAtp1a1 , Atp1a2
hyperinsulinemic hypoglycemiaInsr
Hyperinsulinemic Hypoglycemia, Familial, 5Insr
hyperinsulinismIns2 , Insr , Irs1
HyperkalemiaIns2
HyperoxiaIgf1
HyperphagiaIgf1
HyperplasiaPik3ca
HyperproinsulinemiaIns1 , Ins2
hypertensionAtp1a1 , Atp1a2 , Fxyd2 , Hsd11b1 , Hsd11b2 , Igf1 , Ins2 , Kcnj1 , Kras , Nedd4l , Pik3r1 , Prkca , Prkcb , Scnn1a , Scnn1b , Scnn1g , Sgk1 , Slc9a3r2
Hypertension, Early-Onset, Autosomal Dominant, with Severe Exacerbation in PregnancyNr3c2
hyperthyroidismPpargc1a
HypertriglyceridemiaIns2
hypertrophic cardiomyopathyIgf1 , Ins2
HypertrophyMapk1 , Mapk3
Hypertrophy, Left VentricularPpargc1a , Prkca , Prkcb
Hypertrophy, Right VentricularIgf1 , Ppargc1a , Prkca
hyperuricemiaIns2 , Jak2
hypoglycemiaIns2 , Pik3r1
hypokalemiaIns2
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
HypotensionIns2 , Scnn1g
hypothyroidismIgf1 , Ncoa1 , Ncor1
Hypoxia-Ischemia, BrainDaxx , Igf1
immune system diseasePrkcb
Immunodeficiency 14Pik3cd
Immunodeficiency 36Pik3r1
in situ carcinomaSfn
Infant, Newborn, DiseasesFkbp5
InflammationJak2
inherited metabolic disorderHsd11b2
Insulin ResistanceAtp1a2 , Hsd11b1 , Ins2 , Insr , Irs1 , Irs2 , Pik3r1 , Ppargc1a , Prkcb
Insulin-Like Growth Factor I DeficiencyIgf1
insulinomaIns2
intellectual disabilityKras , Prkcg
Intervertebral Disc DisplacementIgf1
Intestinal NeoplasmsPrkca
Intestinal Reperfusion InjuryJak2
intrahepatic cholangiocarcinomaKras
ischemiaPrkca
juvenile myelomonocytic leukemiaKras
juvenile rheumatoid arthritisKras , Mapk1
Kearns-Sayre syndromePpargc1a
KeloidSfn
kidney diseaseIgf1 , Mapk1
kidney failureIns2 , Ppargc1a
Kidney NeoplasmsKras , Mapk1 , Mapk3 , Ppargc1a
Kidney Reperfusion InjuryDaxx , Ppargc1a
Kuhnt-Junius degenerationIgf1
large cell carcinomaPrkca
Laron syndromeIgf1
leukemiaDaxx , Jak2
LeukocytosisKras
Lewy body dementiaIns2 , Insr
Liddle syndromeScnn1a , Scnn1b , Scnn1g
limited sclerodermaJak2
lipoatrophic diabetes mellitusInsr
lipodystrophyInsr
liver cancerCrebbp , Kras , Pik3ca
liver cirrhosisHsd11b2
Liver InjuryJak2
liver neoplasmKras , Ncor1
Liver Neoplasms, ExperimentalJak2 , Kras , Mapk1 , Mapk3
Liver Reperfusion InjuryJak2
lung adenocarcinomaCrebbp , Kras , Pik3ca , Pik3r1 , Sfn
lung cancerKras , Pik3ca
lung diseaseInsr , Scnn1a , Scnn1b
Lung NeoplasmsKras , Mapk1 , Mapk3 , Pik3ca
lung small cell carcinomaCrebbp , Pik3ca
lung squamous cell carcinomaCrebbp , Kras , Pik3ca
Lymphatic MetastasisPdpk1 , Pik3ca , Pik3cb , Sfn
lymphomaKras
macular degenerationPpargc1a
major depressive disorderFkbp5
malignant fibroxanthomaPpargc1a
malignant gliomaAtp1b2 , Igf1 , Pik3ca
MalocclusionIgf1
Mammary Neoplasms, AnimalPik3r1 , Sgk1 , Ube2i
Mammary Neoplasms, ExperimentalIgf1 , Ncoa1 , Pik3r1 , Sgk1 , Ube2i
mantle cell lymphomaPik3cd
maturity-onset diabetes of the youngIns1 , Ins2
maturity-onset diabetes of the young type 10Ins1 , Ins2
medulloblastomaCrebbp , Irs2 , Pik3ca
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromePik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca , Pik3r2
melanomaAtp1a2 , Atp1b1 , Crebbp , Kras , Pik3ca , Pik3r1 , Ppargc1a
Memory DisordersIns2
mesenteric vascular occlusionJak2
Metabolic Bone DiseasesIgf1
Metabolic SyndromeHsd11b1 , Ins2 , Irs1 , Ppargc1a
microcephalyIgf1
Micronuclei, Chromosome-DefectiveIns2
middle cerebral artery infarctionIgf1 , Prkcg
migraine with auraAtp1a2
Mouth NeoplasmsKras , Pik3ca , Sfn
MPTP PoisoningIns2
mucinous cystadenocarcinomaSgk1
Mucinous CystadenomaDaxx
Multiple AbnormalitiesAtp1a3 , Crebbp , Kras , Mapk1 , Pik3r2
Multiple Hamartoma SyndromePik3ca
multiple myelomaKras , Pik3ca
Multiple Organ FailureMapk1
multiple sclerosisHsp90ab1
Muscle SpasticityCrebbp
muscular atrophyHsp90ab1 , Igf1
muscular diseaseIns2
Muscular Dystrophy, AnimalPpargc1a
myelodysplastic syndromeCrebbp , Kras
myelofibrosisJak2 , Ncor2
myeloid neoplasmJak2 , Kras
myeloid sarcomaKras
myeloproliferative neoplasmJak2
myocardial infarctionHsd11b2 , Igf1 , Jak2 , Mapk1 , Nr3c2 , Ppargc1a
Myocardial IschemiaAtp1a1 , Igf1 , Jak2
Myocardial Reperfusion InjuryJak2 , Mapk1 , Ppargc1a , Prkcb
myopiaIgf1
Nasal PolypsIgf1
Nasopharyngeal NeoplasmsPik3ca
nasopharynx carcinomaKras , Pik3ca
Nematode InfectionsPik3r1
NeointimaIgf1
neonatal diabetes mellitusIns1 , Ins2
Neoplasm InvasivenessIgf1 , Mapk1 , Mapk3
Neoplasm MetastasisDaxx , Hsp90aa1 , Igf1 , Kras , Mapk1 , Mapk3 , Ncoa1 , Pik3ca , Pik3r3
nephrogenic diabetes insipidusPrkca
nephrotic syndromeHsd11b2 , Jak2 , Kcnj1 , Ppargc1a , Scnn1a , Scnn1b
Nerve DegenerationIgf1 , Mapk1 , Mapk3
neural tube defectIns2
Neurobehavioral ManifestationsFkbp5
neuroblastomaKras , Pik3ca , Scnn1a
neuroendocrine tumorDaxx
neuronal ceroid lipofuscinosis 1Ppargc1a
neuronal ceroid lipofuscinosis 6Mapk1 , Mapk3
Niemann-Pick disease type C1Jak2
non-Hodgkin lymphomaPik3ca
non-small cell lung carcinomaKras , Pdpk1 , Pik3ca , Prkcb
nonalcoholic fatty liver diseaseIgf1 , Irs1 , Irs2 , Jak2 , Ppargc1a
Noonan syndromeIgf1 , Kras
Noonan syndrome 3Kras
obesityAtp1a2 , Hsd11b1 , Hsd11b2 , Ins2 , Irs1 , Irs2 , Jak2 , Ncoa1 , Pik3r1 , Ppargc1a , Prkcb
oligodendrogliomaPtges3
osteoarthritisAtp1a3 , Igf1 , Ins2 , Ncor2
Osteoarthritis, KneeHsp90aa1 , Igf1
OsteophyteIgf1
osteoporosisIgf1 , Irs1 , Irs2
Osteoporosis, PostmenopausalIgf1
Osteoporotic FracturesIgf1
ovarian cancerKras , Pik3ca
Ovarian NeoplasmsKras , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Prkca , Sfn , Ube2i
ovarian serous cystadenocarcinomaPik3ca
ovary epithelial cancerDaxx
Oxygen-Induced RetinopathyIgf1
pancreatic adenocarcinomaKras , Pik3ca
pancreatic cancerDaxx , Igf1 , Ins2 , Kras
pancreatic carcinomaKras
pancreatic ductal carcinomaIgf1 , Ins2 , Kras
pancreatic endocrine carcinomaDaxx
Pancreatic Islet Cell TumorsDaxx
pancreatitisHsp90ab1 , Ins2
Pancreatitis, Experimental, Acute Kras
panic disorderIns2
ParalysisIns2
Parasitic Liver DiseasesKras
ParesthesiaIns2
Parkinson's diseaseIns2 , Insr , Ppargc1a
Parkinsonian DisordersAtp1a3 , Ppargc1a
PEHO SyndromeIgf1
penile neoplasmKras , Pik3ca
peripheral nervous system diseaseIgf1
periventricular nodular heterotopiaNedd4l
Periventricular Nodular Heterotopia 7Nedd4l
Periventricular Nodular Heterotopia with Syndactyly, Cleft Palate and Developmental DelayNedd4l
permanent neonatal diabetes mellitusIns1 , Ins2
pilocytic astrocytomaKras
Pituitary NeoplasmsIgf1 , Prkca
placental insufficiencyPpargc1a
Plaque, AtheroscleroticIgf1
plasmacytomaKras , Pik3ca
Pneumococcal PneumoniaMapk1 , Mapk3
polycystic ovary syndromeIgf1 , Ins2 , Ncor1 , Scnn1a
polycythemiaJak2
polycythemia veraJak2
PolyuriaPrkca
portal hypertensionHsp90aa1 , Pik3r1
pre-eclampsiaScnn1a
pre-malignant neoplasmInsr , Irs1
precursor lymphoblastic lymphoma/leukemiaCrebbp , Kras
precursor T-lymphoblastic lymphoma/leukemiaKras
prediabetes syndromePpargc1a
Pregnancy ComplicationsHsd11b2 , Jak2 , Ncoa2
primary biliary cirrhosisJak2 , Ppargc1a
primary hyperaldosteronismAtp1a1
primary hypomagnesemiaFxyd2
progeriaIgf1
prostate adenocarcinomaInsr , Mapk1 , Pdpk1 , Pik3ca , Pik3cb
prostate cancerAtp1a1 , Ins2 , Kcnj1 , Kras , Pdpk1 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Scnn1a
prostate carcinoma in situIgf1 , Kras
Prostatic NeoplasmsCrebbp , Daxx , Hsp90ab1 , Igf1 , Ins2 , Insr , Irs1 , Jak2 , Kras , Mapk3 , Ncoa1 , Ncoa2 , Ncor1 , Ncor2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Prkca
proteinuriaScnn1a
pseudohypoaldosteronismNr3c2 , Scnn1a , Scnn1b , Scnn1g
psoriasisIgf1
psychotic disorderAtp1a3
PTEN hamartoma tumor syndromePik3ca
Puberty, PrecociousIgf1
pulmonary emphysemaPpargc1a
pulmonary fibrosisHsp90ab1 , Igf1
pycnodysostosisIgf1
Radiation Injuries, ExperimentalMapk1 , Mapk3
RASopathiesKras
rectal neoplasmPik3ca , Pik3cb
RecurrenceKras
renal carcinomaPik3ca
renal cell carcinomaInsr , Kras , Mapk1 , Pik3ca , Pik3r1
renal fibrosisKras , Mapk1 , Ppargc1a
renal hypomagnesemia 2Fxyd2
renal hypomagnesemia 6Fxyd2
Reperfusion InjuryIgf1 , Jak2 , Pik3r1 , Prkca
retinal detachmentJak2
retinitis pigmentosaPrkcg
retinopathy of prematurityIgf1
RhabdomyolysisIns2
rheumatic heart diseaseIgf1
rheumatoid arthritisFkbp5 , Hsd11b1 , Hsp90aa1 , Jak2
RhinosinusitisIgf1
Rubinstein-Taybi syndromeCrebbp
sarcomaPik3ca
SarcopeniaIgf1 , Ppargc1a
schizophreniaMapk3 , Pik3cb , Ppargc1a
sciatic neuropathyPpargc1a
scoliosisCrebbp
scrapieJak2
Sebaceous Nevus of JadassohnKras
Sebaceous Nevus Syndrome and HemimegalencephalyKras
seborrheic keratosisPik3ca
Segawa Syndrome, Autosomal RecessiveIns1 , Ins2
seminomaInsr , Kras
sensorineural hearing lossAtp1a1 , Atp1b1 , Prkcb
SepsisIrs1 , Jak2 , Mapk1 , Mapk3 , Ppargc1a
Sepsis-Associated EncephalopathyJak2
Septic PeritonitisPik3r1
serous cystadenocarcinomaSgk1
Sezary's diseaseCrebbp , Mapk1
Shock, HemorrhagicMapk1
short bowel syndromeInsr
SHORT SyndromePik3r1
silicosisPrkcb
Silver-Russell syndromeIns1
skin diseasePias1
Skin NeoplasmsIgf1
Skull FracturesIgf1
Sleep Initiation and Maintenance DisordersPpargc1a
Smith-Magenis syndromePrkca
spina bifidaCrebbp
Spinal Cord InjuriesHsp90ab1 , Jak2 , Ppargc1a
spinocerebellar ataxia type 14Prkcg
Spinocerebellar AtaxiasPrkcg
SplenomegalyKras
Spondylocostal Dysostosis 5Mapk3
Sporadic Papillary Renal Cell CarcinomaPik3ca
squamous cell carcinomaCrebbp , Kras , Mapk1 , Mapk3 , Pik3ca , Sfn
status epilepticusHsd11b1 , Prkcb
stomach cancerKras , Pik3ca
Stomach NeoplasmsIrs2 , Kras , Mapk1 , Mapk3 , Pik3ca , Prkcb
StrokeIgf1 , Jak2 , Nedd4l , Pik3ca , Scnn1a
substance-related disorderAtp1b1 , Insr
syndactylyNedd4l
systemic lupus erythematosusJak2
TachycardiaIns2
Takotsubo CardiomyopathyPpargc1a
Telomeric 22q13 Monosomy SyndromeIns2
tethered spinal cord syndromeCrebbp
ThinnessIgf1
Thrombocythemia 3Jak2
thrombocytosisJak2
ThromboembolismJak2
thrombosisPik3cb
Thumb DeformityCrebbp
thyroid hormone resistance syndromeNcoa1
thyroid medullary carcinomaKras
Thyroid NeoplasmsKras , Pik3ca
Tongue NeoplasmsIgf1
transient cerebral ischemiaDaxx , Igf1 , Jak2 , Sgk1
transitional cell carcinomaCrebbp , Daxx , Kras , Mapk1 , Ncor1 , Pik3ca , Sfn
trigeminal neuralgiaMapk1 , Mapk3 , Prkcg
Turner syndromeIgf1
type 1 diabetes mellitusHsd11b2 , Igf1 , Ins2 , Ppargc1a
type 1 diabetes mellitus 2Ins1 , Ins2
type 2 diabetes mellitusHsd11b1 , Hsd11b2 , Igf1 , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Mapk1 , Mapk3 , Pik3cb , Pik3r1 , Ppargc1a , Prkcb
ulcerative colitisJak2
uremiaSgk1
ureteral obstructionHsd11b2
urethral obstructionMapk1
urinary bladder cancerCrebbp , Igf1 , Kras , Ncor1 , Prkca , Sfn , Ube2i
Urinary Bladder NeoplasmKras
Urinary IncontinenceMapk1
uterine carcinosarcomaPik3ca , Pik3r1
Uterine Cervical NeoplasmsCrebbp , Jak2 , Kras , Mapk1 , Pik3ca
Uterine NeoplasmsKras , Pik3ca , Pik3r1
uveal melanomaIgf1
vascular dementiaIgf1
Vascular MalformationsPik3ca
velocardiofacial syndromeMapk1
Venous ThrombosisJak2
Ventilator-Induced Lung InjuryAtp1a2
Ventricular Dysfunction, LeftAtp1a3 , Ins2 , Nr3c2
Ventricular FibrillationIns2
Ventricular Outflow ObstructionIns2
vestibular diseaseAtp1a1
visual epilepsyAtp1a3 , Ins2 , Pik3ca
vitiligoPik3r1
Vulvar NeoplasmsSfn
Wegener's granulomatosisIgf1
Weight GainPik3ca
Weight LossIns2
Weissenbacher-Zweymuller syndromeMapk1
withdrawal disorderMapk1 , Mapk3
Wounds and InjuriesIgf1
Zinc DeficiencyIgf1
Pathway Annotations Associated with Genes in the aldosterone signaling pathway
Pathway TermsGene Symbols
11-beta-hydroxylase deficiency pathwayHsd11b1 , Hsd11b2
17-alpha-hydroxylase deficiency pathwayHsd11b1 , Hsd11b2
21-alpha-hydroxylase deficiency pathwayHsd11b1 , Hsd11b2
acebutolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
acute myeloid leukemia pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
adenosine signaling pathwayMapk1 , Pdpk1 , Pik3ca
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
aldosterone signaling pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Casp8ap2 , Crebbp , Daxx , Dhx9 , Ell , Faf1 , Fkbp4 , Fkbp5 , Fxyd2 , Fxyd4 , Hsd11b1 , Hsd11b2 , Hsp90aa1 , Hsp90ab1 , Igf1 , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Jak2 , Kcnj1 , Kras , Mapk1 , Mapk3 , Ncoa1 , Ncoa2 , Ncor1 , Ncor2 , Nedd4l , Nfyc , Nr3c2 , Pdpk1 , Pias1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkca , Prkcb , Prkcg , Ptges3 , Scnn1a , Scnn1b , Scnn1g , Sfn , Sgk1 , Slc9a3r2 , Ube2i
alfentanil pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
altered androgen signaling pathwayNcoa2 , Ncor2
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayKras
altered insulin signaling pathwayIns2 , Insr
altered insulin-like growth factor signaling pathwayIgf1
altered Jak-Stat signaling pathwayJak2
altered leptin system pathwayInsr
altered p53 signaling pathwayNfyc
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayPik3ca
altered ubiquitin/proteasome degradation pathwayUbe2i
Alzheimer's disease pathwayMapk1 , Mapk3 , Ube2i
amiloride pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
amiodarone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
amlodipine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
amyotrophic lateral sclerosis pathwayDaxx
androgen signaling pathwayCrebbp , Hsp90aa1 , Hsp90ab1 , Ncoa1 , Ncoa2 , Ncor1 , Ncor2
angiotensin II signaling pathwayJak2 , Pdpk1
angiotensin II signaling pathway via AT1 receptorJak2
antigen processing and presentation pathwayHsp90aa1 , Hsp90ab1 , Nfyc
apoptotic cell death pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
apparent mineralocorticoid excess syndrome pathwayHsd11b1 , Hsd11b2
ataxia telangiectasia-mutated (ATM) signaling pathwayPias1
atenolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
autophagy pathwayIns1 , Ins2
B cell receptor signaling pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcb
bendroflumethiazide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
betaxolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
bile acid transport pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
bisoprolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
Bone morphogenetic proteins signaling pathwayMapk1
bumetanide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
bupivacaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
bupranolol drug pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
bupranolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
buprenorphine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
calcium/calcium-mediated signaling pathwayPrkca , Prkcb , Prkcg
cardiovascular system disease pathwayIgf1
carvedilol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
cell cycle pathway, mitoticCrebbp , Sfn
ceramide signaling pathwayIgf1 , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Chagas disease pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
chaperone mediated autophagy pathwayHsp90aa1
chemokine mediated signaling pathwayJak2 , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcb
chloroprocaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
chlorothiazide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
chlorthalidone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
chronic myeloid leukemia pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
citalopram pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
cocaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
codeine and morphine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
colorectal cancer pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
corticosteroid signaling pathwaySgk1
cortisol signaling pathwayCrebbp , Fkbp4 , Fkbp5 , Hsp90aa1 , Hsp90ab1 , Ncoa1 , Ncoa2 , Ncor1 , Ncor2 , Ptges3
cystinuria pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
desipramine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
dilated cardiomyopathy pathwayIgf1
diltiazem pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
diphenoxylate pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
disopyramide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
dobutamine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
E-cadherin signaling pathwayIgf1 , Pik3ca , Pik3r1
eicosanoid signaling pathwayPik3r5 , Prkca , Prkcg
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwayNedd4l
endometrial cancer pathwayKras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Endoplasmic Reticulum-associated degradation pathwayHsp90aa1 , Hsp90ab1
endothelin signaling pathwayJak2 , Mapk1 , Mapk3 , Prkca , Prkcg
Entamoebiasis pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
ephrin - ephrin receptor bidirectional signaling axisMapk1 , Mapk3 , Pik3ca , Pik3r1 , Pik3r5
epidermal growth factor/neuregulin signaling pathwayHsp90aa1 , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
eplerenone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
erythropoietin signaling pathwayIrs2 , Jak2 , Pik3r1
escitalopram pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
esmolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
estrogen signaling pathwayCrebbp , Fkbp4 , Hsp90aa1 , Hsp90ab1 , Ncoa1 , Ncoa2 , Ncor1 , Ncor2 , Ptges3
etacrynic acid pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
ethylmorphine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
FasL mediated signaling pathwayPdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcg
Fc gamma receptor mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
fentanyl pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
fibroblast growth factor signaling pathwayMapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1
flecainde pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
fluoxetine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
forkhead class A signaling pathwayCrebbp , Ins2
fosphenytoin pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
furosemide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
gliclazide pharmacodynamics pathwayIns2
glioma pathwayIgf1 , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
glutamate signaling pathwayMapk1 , Mapk3 , Prkca , Prkcb , Prkcg
glyburide pharmacodynamics pathwayIns2
gonadotropin-releasing hormone signaling pathwayKras , Mapk1 , Mapk3 , Prkca , Prkcb
granulocyte-macrophage colony-stimulating factor signaling pathwayJak2 , Mapk1 , Mapk3 , Pik3ca , Pik3r1
growth hormone signaling pathwayJak2
Hartnup disease pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
Hedgehog signaling pathwayCrebbp , Pias1 , Pik3ca , Pik3r1
hepatitis C pathwayKras , Mapk1 , Mapk3 , Pias1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
heroin pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
histone modification pathwayCrebbp , Daxx
Huntington's disease pathwayCrebbp , Ppargc1a
hydrochlorothiazide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
hydrocodone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
hydroflumethiazide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
hydromorphone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
hypertrophic cardiomyopathy pathwayIgf1
hypoxia inducible factor pathwayCrebbp , Ncoa1 , Ncoa2
ibutilide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
iminoglycinuria pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
imipramine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
influenza A pathwayCrebbp , Jak2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayIns2 , Insr , Sfn
insulin signaling pathwayIns1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Kras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkca , Prkcb , Prkcg , Sgk1
insulin-like growth factor signaling pathwayIgf1 , Irs1 , Irs2 , Irs4 , Pdpk1 , Pik3ca , Pik3r1
interleukin-1 signaling pathwayPik3ca , Pik3r1
interleukin-12 signaling pathwayJak2
interleukin-2 signaling pathwayIrs1 , Irs2 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Prkcb
interleukin-23 signaling pathwayJak2 , Pik3ca , Pik3r1
interleukin-27 signaling pathwayJak2
interleukin-3 signaling pathwayJak2 , Pik3ca , Pik3r1
interleukin-4 signaling pathwayIrs1 , Irs2 , Jak2 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayJak2 , Pik3ca , Pik3r1
interleukin-6 signaling pathwayJak2 , Pias1 , Pik3ca , Pik3r1
isoprenaline pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
isradipine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
Jak-Stat signaling pathwayCrebbp , Jak2 , Pias1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
lactose degradation pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
Leishmaniasis pathwayJak2 , Mapk1 , Mapk3 , Prkcb
leptin system pathwayIrs1 , Irs2 , Jak2
levacetylmethadol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
levobunolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
levobupivacaine phgarmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
levorphanol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
lidocaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
lipoid congenital adrenal hyperplasia pathwayHsd11b1 , Hsd11b2
long term depressionIgf1 , Kras , Mapk1 , Mapk3 , Prkca , Prkcb , Prkcg
long term potentiationCrebbp , Kras , Mapk1 , Mapk3 , Prkca , Prkcb , Prkcg
lysinuric protein intolerance pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
maturity-onset diabetes of the young pathwayIns1 , Ins2
measles pathwayJak2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
melanoma pathwayIgf1 , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
mepivacaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
methadone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
metolazone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
metoprolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
mexiletine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
mitogen activated protein kinase signaling pathwayDaxx , Kras , Mapk1 , Mapk3 , Prkca , Prkcb , Prkcg
mTOR signaling pathwayIgf1 , Ins1 , Ins2 , Irs1 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkca , Sfn , Sgk1
N-cadherin signaling pathwayPik3ca , Pik3r1
nadolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
nalbuphine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
naloxone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
naltrexone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
nebivolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
neurotrophic factor signaling pathwayIrs1 , Irs2 , Irs3 , Irs4 , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
nicotine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
nifedipine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
nimodipine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
nisoldipine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
nitrendipine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
NOD-like receptor signaling pathwayHsp90aa1 , Hsp90ab1 , Mapk1 , Mapk3
non-small cell lung carcinoma pathwayKras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
Notch signaling pathwayCrebbp , Ncor1 , Ncor2
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1 , Prkca
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp
oxybuprocaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
oxycodone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
oxymorphone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
p53 signaling pathwayCrebbp , Daxx , Igf1 , Sfn
pancreatic cancer pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
parathyroid hormone signaling pathwaySlc9a3r2
penbutolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
pentazocine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
phenytoin pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
phosphatidylinositol 3-kinase class I signaling pathwayHsp90aa1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sgk1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
phosphatidylinositol 3-kinase-Akt signaling pathwayHsp90aa1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Sfn
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
pindolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
platelet-derived growth factor signaling pathwayJak2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Sfn
potassium channel inhibitors pharmacodynamics pathwayIns2
prednisolone pharmacodynamics pathwayHsp90aa1
prednisolone pharmacokinetics pathwayHsp90aa1
prilocaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
prion disease pathwayMapk1 , Mapk3
procainamide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
procaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
propranolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
prostaglandin biosynthetic pathwayPtges3
prostate cancer pathwayCrebbp , Hsp90aa1 , Hsp90ab1 , Igf1 , Ins1 , Ins2 , Kras , Mapk1 , Mapk3 , Ncoa2 , Ncor2 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
protein kinase C (PKC) signaling pathwayHsp90aa1 , Pdpk1 , Prkca , Prkcb , Prkcg
quinidine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
Reelin signaling pathwayPik3ca , Pik3r1
remifentanil pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
renal cell carcinoma pathwayCrebbp , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
retinoic acid signaling pathwayNcoa1 , Ncoa2 , Ncor1 , Ncor2
ribosome biogenesis pathwayPrkcb
RNA polymerase I transcription pathwayCrebbp
RNA polymerase II transcription elongation pathwayEll
RNA transport pathwayUbe2i
ropivacaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
sleeping sickness pathwayPrkca , Prkcb , Prkcg
small cell lung carcinoma pathwayPias1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
somatostatin signaling pathwayJak2
sotalol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
sphingosine 1-phosphate signaling pathwayIrs1 , Jak2 , Mapk1 , Mapk3
spironolactone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
steroid hormone biosynthetic pathwayHsd11b1 , Hsd11b2
sumoylation pathwayUbe2i
syndecan signaling pathwayMapk1 , Mapk3 , Prkca
T cell receptor signaling pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
tamoxifen pharmacodynamics pathwayNcor1 , Ncor2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayKras , Mapk1 , Mapk3
thyroid cancer pathwayKras , Mapk1 , Mapk3
timolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
Toll-like receptor signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
torasemide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
toxoplasmosis pathwayJak2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Trail mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
tramadol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
transforming growth factor-beta Smad dependent signaling pathwayCrebbp , Daxx , Nedd4l , Pdpk1
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Mapk1 , Mapk3
trehalose degradation pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
triamterene pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
trichlormethiazide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
tuberculosis pathwayCrebbp , Jak2 , Mapk1 , Mapk3 , Nfyc
type 1 diabetes mellitus pathwayIns1 , Ins2
type 2 diabetes mellitus pathwayIns1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayCrebbp , Jak2 , Mapk1 , Mapk3 , Pias1 , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayNedd4l , Pias1 , Ube2i
urinary bladder cancer pathwayKras , Mapk1 , Mapk3
vascular endothelial growth factor signaling pathwayHsp90aa1 , Hsp90ab1 , Kras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
verapamil pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
Wnt signaling pathwayCrebbp , Prkca , Prkcb , Prkcg
Wnt signaling, canonical pathwayCrebbp
Phenotype Annotations Associated with Genes in the aldosterone signaling pathway
Phenotype TermsGene Symbols
cardiac hypertrophyCrebbp , Igf1

References Associated with the aldosterone signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: