ALDOSTERONE SIGNALING PATHWAY (PW:0000568)

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Description

Aldosterone signaling plays a major role in the control of blood pressure by regulating sodium reabsorption in the kidney via expression of its target genes. Aldosterone is a steroid hormone that engages the aldosterone receptor, also known as the mineralocorticoid receptor - a member of the nuclear receptor family that belongs to subfamily 3 (Nr3c2). A unique feature of this receptor is that, in addition to aldosterone, it can be bound by different steroid hormones such as other mineralocortico

Pathway Diagram:

Ariadne Genomics Inc. Hsd11b2 ---| Nr3c2 cortisol ---- Nr3c2 cortisone cortisol aldosterone aldosterone biosynthetic pathway steroid hormone biosynthetic pathway Nr3c2 target genes Hsd11b2 Nr3c2 ---> translocated Nr3c2 complex translocated Nr3c2 complex Nr3c2 aldosterone ---- Nr3c2 cortisol ---> cortisone Nr3c2 ---- Nr3c2 chaperones Nr3c2 corepressors ---- translocated Nr3c2 complex Nr3c2 coactivators ---- translocated Nr3c2 complex Nr3c2 coactivators --+> translocated Nr3c2 complex Nr3c2 corepressors ---| translocated Nr3c2 complex translocated Nr3c2 complex ---> Nr3c2 target genes Nr3c2 chaperones Nr3c2 corepressors Nr3c2 coactivators
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Genes in Pathway:

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aldosterone signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 JBrowse link 2 204,003,742 204,032,023 RGD:6907045
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 JBrowse link 13 90,651,682 90,676,629 RGD:6907045
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 JBrowse link 1 81,852,423 81,881,565 RGD:6907045
G Atp1a4 ATPase Na+/K+ transporting subunit alpha 4 JBrowse link 13 90,605,792 90,642,032 RGD:6907045
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 JBrowse link 13 82,737,161 82,757,681 RGD:6907045
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 JBrowse link 10 56,205,622 56,211,879 RGD:6907045
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 JBrowse link 8 104,190,032 104,221,342 RGD:6907045
G Atp1b4 ATPase Na+/K+ transporting family member beta 4 JBrowse link X 124,631,544 124,652,520 RGD:6907045
G Casp8ap2 caspase 8 associated protein 2 JBrowse link 5 47,853,699 47,891,147 RGD:7421504
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:7421504
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:7421504
G Dhx9 DExH-box helicase 9 JBrowse link 13 70,885,503 70,922,278 RGD:7421504
G Ell elongation factor for RNA polymerase II JBrowse link 16 20,594,129 20,641,441 RGD:7421504
G Faf1 Fas associated factor 1 JBrowse link 5 129,370,767 129,738,393 RGD:7421504
G Fkbp4 FK506 binding protein 4 JBrowse link 4 161,748,993 161,757,447 RGD:7421504
G Fkbp5 FK506 binding protein 5 JBrowse link 20 7,976,704 8,097,290 RGD:7421504
G Fxyd2 FXYD domain-containing ion transport regulator 2 JBrowse link 8 49,710,334 49,717,492 RGD:6907045
G Fxyd4 FXYD domain-containing ion transport regulator 4 JBrowse link 4 149,984,206 149,988,744 RGD:6907045
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 JBrowse link 13 111,946,626 111,996,536 RGD:6907045
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 JBrowse link 19 37,476,083 37,481,326 RGD:6907045
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:7421504
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:7421504
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6907045
G Ins1 insulin 1 JBrowse link 1 272,799,784 272,800,351 RGD:6907045
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6907045
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:6907045
G Irs1 insulin receptor substrate 1 JBrowse link 9 88,033,668 88,086,488 RGD:6907045
G Irs2 insulin receptor substrate 2 JBrowse link 16 83,824,515 83,848,569 RGD:6907045
G Irs3 insulin receptor substrate 3 JBrowse link 12 22,120,305 22,125,103 RGD:6907045
G Irs4 insulin receptor substrate 4 JBrowse link X 113,003,824 113,018,088 RGD:6907045
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1641841
G Kcnj1 potassium voltage-gated channel subfamily J member 1 JBrowse link 8 33,490,280 33,519,127 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Ncoa1 nuclear receptor coactivator 1 JBrowse link 6 28,677,563 28,931,844 RGD:7421504
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:7421504
G Ncor1 nuclear receptor co-repressor 1 JBrowse link 10 48,629,121 48,772,890 RGD:7421504
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:7421504
G Nedd4l neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase JBrowse link 18 60,392,376 60,719,720 RGD:6907045
G Nfyc nuclear transcription factor Y subunit gamma JBrowse link 5 139,687,442 139,760,154 RGD:7421504
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 JBrowse link 19 34,408,275 34,761,003 RGD:6907045
RGD:7421504
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6907045
G Pias1 protein inhibitor of activated STAT, 1 JBrowse link 8 67,771,720 67,869,015 RGD:7421504
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:7421504
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6907045
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6907045
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6907045
G Ptges3 prostaglandin E synthase 3 JBrowse link 7 2,479,267 2,497,024 RGD:7421504
G Scnn1a sodium channel epithelial 1 alpha subunit JBrowse link 4 157,834,339 157,860,472 RGD:6907045
G Scnn1b sodium channel epithelial 1 beta subunit JBrowse link 1 191,829,547 191,883,991 RGD:6907045
G Scnn1g sodium channel epithelial 1 gamma subunit JBrowse link 1 191,704,397 191,738,271 RGD:6907045
G Sfn stratifin JBrowse link 5 151,823,422 151,824,937 RGD:6907045
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 1 24,185,451 24,302,309 RGD:6907045
G Slc9a3r2 SLC9A3 regulator 2 JBrowse link 10 14,003,330 14,015,066 RGD:6907045
G Ube2i ubiquitin-conjugating enzyme E2I JBrowse link 10 14,618,615 14,639,274 RGD:7421504

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassNr3c2 chaperonesaldosterone receptor chaperones
Functional ClassNr3c2 coactivatorsaldosterone receptor coactivators
Functional ClassNr3c2 corepressorsaldosterone receptor corepressors
Gene GroupNr3c2 target genesaldosterone receptor target genes

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the aldosterone signaling pathway
Pathway TermsGene Symbols
11-beta-hydroxylase deficiency pathwayHsd11b1 , Hsd11b2
17-alpha-hydroxylase deficiency pathwayHsd11b1 , Hsd11b2
21-alpha-hydroxylase deficiency pathwayHsd11b1 , Hsd11b2
acebutolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
acute myeloid leukemia pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
adenosine signaling pathwayMapk1 , Pdpk1 , Pik3ca
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
aldosterone signaling pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Casp8ap2 , Crebbp , Daxx , Dhx9 , Ell , Faf1 , Fkbp4 , Fkbp5 , Fxyd2 , Fxyd4 , Hsd11b1 , Hsd11b2 , Hsp90aa1 , Hsp90ab1 , Igf1 , Ins1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Jak2 , Kcnj1 , Kras , Mapk1 , Mapk3 , Ncoa1 , Ncoa2 , Ncor1 , Ncor2 , Nedd4l , Nfyc , Nr3c2 , Pdpk1 , Pias1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkca , Prkcb , Prkcg , Ptges3 , Scnn1a , Scnn1b , Scnn1g , Sfn , Sgk1 , Slc9a3r2 , Ube2i
alfentanil pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
altered androgen signaling pathwayNcoa2 , Ncor2
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayKras
altered insulin signaling pathwayIns2 , Insr
altered insulin-like growth factor signaling pathwayIgf1
altered Jak-Stat signaling pathwayJak2
altered leptin system pathwayInsr
altered p53 signaling pathwayNfyc
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayPik3ca
altered ubiquitin/proteasome degradation pathwayUbe2i
Alzheimer disease pathwayMapk1 , Mapk3 , Ube2i
amiloride pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
amiodarone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
amlodipine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
amyotrophic lateral sclerosis disease pathwayDaxx
androgen signaling pathwayCrebbp , Hsp90aa1 , Hsp90ab1 , Ncoa1 , Ncoa2 , Ncor1 , Ncor2
angiotensin II signaling pathwayJak2 , Pdpk1
angiotensin II signaling pathway via AT1 receptorJak2
antigen processing and presentation pathwayHsp90aa1 , Hsp90ab1 , Nfyc
apoptotic cell death pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
apparent mineralocorticoid excess syndrome pathwayHsd11b1 , Hsd11b2
ataxia telangiectasia-mutated (ATM) signaling pathwayPias1
atenolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
autophagy pathwayIns1 , Ins2
B cell receptor signaling pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcb
bendroflumethiazide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
betaxolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
bile acid transport pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
bisoprolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
bladder cancer pathwayKras , Mapk1 , Mapk3
Bone morphogenetic proteins signaling pathwayMapk1
bumetanide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
bupivacaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
bupranolol drug pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
bupranolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
buprenorphine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
calcium/calcium-mediated signaling pathwayPrkca , Prkcb , Prkcg
cardiovascular system disease pathwayIgf1
carvedilol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
cell cycle pathway, mitoticCrebbp , Sfn
ceramide signaling pathwayIgf1 , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
chaperone mediated autophagy pathwayHsp90aa1
chemokine mediated signaling pathwayJak2 , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkcb
chloroprocaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
chlorothiazide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
chlorthalidone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
chronic myeloid leukemia pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
citalopram pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
cocaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
codeine and morphine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
colorectal cancer pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
corticosteroid signaling pathwaySgk1
cortisol signaling pathwayCrebbp , Fkbp4 , Fkbp5 , Hsp90aa1 , Hsp90ab1 , Ncoa1 , Ncoa2 , Ncor1 , Ncor2 , Ptges3
cystinuria disease pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
desipramine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
dilated cardiomyopathy pathwayIgf1
diltiazem pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
diphenoxylate pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
disopyramide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
dobutamine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
E-cadherin signaling pathwayIgf1 , Pik3ca , Pik3r1
eicosanoid signaling pathwayPik3r5 , Prkca , Prkcg
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwayNedd4l
endometrial cancer pathwayKras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Endoplasmic Reticulum-associated degradation pathwayHsp90aa1 , Hsp90ab1
endothelin signaling pathwayJak2 , Mapk1 , Mapk3 , Prkca , Prkcg
Entamoeba histolyca infection pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
ephrin - ephrin receptor bidirectional signaling axisMapk1 , Mapk3 , Pik3ca , Pik3r1 , Pik3r5
epidermal growth factor/neuregulin signaling pathwayHsp90aa1 , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
eplerenone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
erythropoietin signaling pathwayIrs2 , Jak2 , Pik3r1
escitalopram pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
esmolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
estrogen signaling pathwayCrebbp , Fkbp4 , Hsp90aa1 , Hsp90ab1 , Ncoa1 , Ncoa2 , Ncor1 , Ncor2 , Ptges3
etacrynic acid pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
ethylmorphine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
FasL mediated signaling pathwayPdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcg
Fc gamma receptor mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
fentanyl pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
fibroblast growth factor signaling pathwayMapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1
flecainde pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
fluoxetine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
forkhead class A signaling pathwayCrebbp , Ins2
fosphenytoin pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
furosemide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
gliclazide pharmacodynamics pathwayIns2
glioma pathwayIgf1 , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
glutamate signaling pathwayMapk1 , Mapk3 , Prkca , Prkcb , Prkcg
glyburide pharmacodynamics pathwayIns2
gonadotropin-releasing hormone signaling pathwayKras , Mapk1 , Mapk3 , Prkca , Prkcb
granulocyte-macrophage colony-stimulating factor signaling pathwayJak2 , Mapk1 , Mapk3 , Pik3ca , Pik3r1
growth hormone signaling pathwayJak2
Hartnup disease pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
Hedgehog signaling pathwayCrebbp , Pias1 , Pik3ca , Pik3r1
hepatitis C virus infection pathwayKras , Mapk1 , Mapk3 , Pias1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
heroin pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
histone modification pathwayCrebbp , Daxx
Huntington disease pathwayCrebbp , Ppargc1a
hydrochlorothiazide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
hydrocodone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
hydroflumethiazide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
hydromorphone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
hypertrophic cardiomyopathy pathwayIgf1
hypoxia inducible factor pathwayCrebbp , Ncoa1 , Ncoa2
ibutilide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
iminoglycinuria disease pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
imipramine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
influenza A virus infection pathwayCrebbp , Jak2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayIns2 , Insr , Sfn
insulin signaling pathwayIns1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Kras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkca , Prkcb , Prkcg , Sgk1
insulin-like growth factor signaling pathwayIgf1 , Irs1 , Irs2 , Irs4 , Pdpk1 , Pik3ca , Pik3r1
interleukin-1 signaling pathwayPik3ca , Pik3r1
interleukin-12 signaling pathwayJak2
interleukin-2 signaling pathwayIrs1 , Irs2 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Prkcb
interleukin-23 signaling pathwayJak2 , Pik3ca , Pik3r1
interleukin-27 signaling pathwayJak2
interleukin-3 signaling pathwayJak2 , Pik3ca , Pik3r1
interleukin-4 signaling pathwayIrs1 , Irs2 , Jak2 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayJak2 , Pik3ca , Pik3r1
interleukin-6 signaling pathwayJak2 , Pias1 , Pik3ca , Pik3r1
isoprenaline pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
isradipine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
Jak-Stat signaling pathwayCrebbp , Jak2 , Pias1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
lactose degradation pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
Leishmania infection pathwayJak2 , Mapk1 , Mapk3 , Prkcb
leptin system pathwayIrs1 , Irs2 , Jak2
levacetylmethadol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
levobunolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
levobupivacaine phgarmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
levorphanol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
lidocaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
lipoid congenital adrenal hyperplasia disease pathwayHsd11b1 , Hsd11b2
long term depressionIgf1 , Kras , Mapk1 , Mapk3 , Prkca , Prkcb , Prkcg
long term potentiationCrebbp , Kras , Mapk1 , Mapk3 , Prkca , Prkcb , Prkcg
lysinuric protein intolerance disease pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
maturity onset diabetes of the young pathwayIns1 , Ins2
measles infection pathwayJak2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
melanoma pathwayIgf1 , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
mepivacaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
methadone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
metolazone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
metoprolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
mexiletine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
mitogen activated protein kinase signaling pathwayDaxx , Kras , Mapk1 , Mapk3 , Prkca , Prkcb , Prkcg
mTOR signaling pathwayIgf1 , Ins1 , Ins2 , Irs1 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkca , Sfn , Sgk1
Mycobacterium tuberculosis infection pathwayCrebbp , Jak2 , Mapk1 , Mapk3 , Nfyc
N-cadherin signaling pathwayPik3ca , Pik3r1
nadolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
nalbuphine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
naloxone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
naltrexone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
nebivolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
neurotrophic factor signaling pathwayIrs1 , Irs2 , Irs3 , Irs4 , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
nicotine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
nifedipine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
nimodipine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
nisoldipine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
nitrendipine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
NOD-like receptor signaling pathwayHsp90aa1 , Hsp90ab1 , Mapk1 , Mapk3
non-small cell lung cancer pathwayKras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
Notch signaling pathwayCrebbp , Ncor1 , Ncor2
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1 , Prkca
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp
oxybuprocaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
oxycodone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
oxymorphone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
p53 signaling pathwayCrebbp , Daxx , Igf1 , Sfn
pancreatic cancer pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
parathyroid hormone signaling pathwaySlc9a3r2
penbutolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
pentazocine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
phenytoin pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
phosphatidylinositol 3-kinase class I signaling pathwayHsp90aa1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sgk1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
phosphatidylinositol 3-kinase-Akt signaling pathwayHsp90aa1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Sfn
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
pindolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
platelet-derived growth factor signaling pathwayJak2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Sfn
potassium channel inhibitors pharmacodynamics pathwayIns2
prednisolone pharmacodynamics pathwayHsp90aa1
prednisolone pharmacokinetics pathwayHsp90aa1
prilocaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
prion diseases pathwayMapk1 , Mapk3
procainamide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
procaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
propranolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
prostaglandin biosynthetic pathwayPtges3
prostate cancer pathwayCrebbp , Hsp90aa1 , Hsp90ab1 , Igf1 , Ins1 , Ins2 , Kras , Mapk1 , Mapk3 , Ncoa2 , Ncor2 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
protein kinase C (PKC) signaling pathwayHsp90aa1 , Pdpk1 , Prkca , Prkcb , Prkcg
quinidine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
Reelin signaling pathwayPik3ca , Pik3r1
remifentanil pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
renal cell cancer pathwayCrebbp , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
retinoic acid signaling pathwayNcoa1 , Ncoa2 , Ncor1 , Ncor2
ribosome biogenesis pathwayPrkcb
RNA polymerase I transcription pathwayCrebbp
RNA polymerase II transcription elongation pathwayEll
RNA transport pathwayUbe2i
ropivacaine pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
small cell lung cancer pathwayPias1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
somatostatin signaling pathwayJak2
sotalol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
sphingosine 1-phosphate signaling pathwayIrs1 , Jak2 , Mapk1 , Mapk3
spironolactone pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
steroid hormone biosynthetic pathwayHsd11b1 , Hsd11b2
sumoylation pathwayUbe2i
syndecan signaling pathwayMapk1 , Mapk3 , Prkca
T cell receptor signaling pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
tamoxifen pharmacodynamics pathwayNcor1 , Ncor2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayKras , Mapk1 , Mapk3
thyroid cancer pathwayKras , Mapk1 , Mapk3
timolol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
Toll-like receptor signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
torasemide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
Toxoplasma gondii infection pathwayJak2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Trail mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
tramadol pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
transforming growth factor-beta Smad dependent signaling pathwayCrebbp , Daxx , Nedd4l , Pdpk1
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Mapk1 , Mapk3
trehalose degradation pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
triamterene pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
trichlormethiazide pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2 , Nr3c2 , Scnn1a , Scnn1b , Scnn1g
Trypanosoma brucei infection pathwayPrkca , Prkcb , Prkcg
Trypanosoma cruzi infection pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type 1 diabetes mellitus pathwayIns1 , Ins2
type 2 diabetes mellitus pathwayIns1 , Ins2 , Insr , Irs1 , Irs2 , Irs3 , Irs4 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayCrebbp , Jak2 , Mapk1 , Mapk3 , Pias1 , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayNedd4l , Pias1 , Ube2i
vascular endothelial growth factor signaling pathwayHsp90aa1 , Hsp90ab1 , Kras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Prkcb , Prkcg
verapamil pharmacodynamics pathwayAtp1a1 , Atp1a2 , Atp1a3 , Atp1a4 , Atp1b1 , Atp1b2 , Atp1b3 , Atp1b4 , Fxyd2
Wnt signaling pathwayCrebbp , Prkca , Prkcb , Prkcg
Wnt signaling, canonical pathwayCrebbp
Phenotype Annotations Associated with Genes in the aldosterone signaling pathway
Phenotype TermsGene Symbols
cardiac hypertrophyCrebbp , Igf1

References Associated with the aldosterone signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: