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MTOR SIGNALING PATHWAY (PW:0000180)

View Ontology Report

Description

The mTOR signaling pathway responds to and integrates a range of environmental cues and is known for its role in the control of protein translation and ribosome biogenesis, autophagy, cytoskeleton, and metabolism. The highly conserved Ser/Thr mTOR kinase is found in two distinct complexes: the rapamycin-sensitive mTORC1 and the largely rapamycin-insensitive mTORC2. Rapamycin (sirolimus) - a macrolide produced by Streptomyces hygroscopicus, in complex with Fkbp1a (the 12-kDa FK506-binding

Pathway Diagram:

Elsevier Inc. translation initiation pathway TSC complex Akt1s1 Gatsl3 insulin signaling pathway mTORC1 complex GF leucine ribosome biogenesis pathway translation pathway nuclear factor, erythroid 2 like 2 signaling pathway autophagy pathway phosphatidylinositol 3-kinase-Akt signaling pathway the extracellular signal-regulated Raf/Mek/Erk signaling pathway adenosine monophosphate-activated protein kinase (AMPK) signaling pathway Irs1 Rheb Rrag members rapamycin Flcn-Flip mTORC2 complex Gator2 complex Ragulator complex Gator1 complex Rrag members ---> mTORC1 complex phosphatidylinositol 3-kinase-Akt signaling pathway ---| Tsc2 the extracellular signal-regulated Raf/Mek/Erk signaling pathway ---| Tsc2 Tsc1 Tsc2 Rheb --+> mTORC1 complex insulin signaling pathway --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway insulin signaling pathway --+> phosphatidylinositol 3-kinase-Akt signaling pathway environmental cues Rrag members --+> mTORC1 complex mTORC2 complex --+> cytoskeletal rearrangements cytoskeletal rearrangements Flcn-Flip --+> Rrag members Gator2 complex ---| Gator1 complex Ragulator complex --+> Rrag members Gator2 complex ---- Sesn2 Sesn2 ---| Gator2 complex Gator2 complex ---- Gatsl2 Gator2 complex ---- Gatsl3 Gatsl3 ---| Gator2 complex Gatsl2 ---| Gator2 complex Rps6kb1 ---| Irs1 leucine ---- Sesn2 Rps6kb1 Rps6kb1 --+> translation initiation pathway Eif4ebp1 ---| translation initiation pathway mTORC1 complex --+> Rps6kb1 translation initiation pathway ---> ribosome biogenesis pathway Eif4ebp1 mTORC1 complex ---| Eif4ebp1 mTORC1 complex ---| autophagy pathway mTORC1 complex --+> nuclear factor, erythroid 2 like 2 signaling pathway Sesn2 leucine ---| Sesn2 arginine ---| Gatsl3 environmental cues --+> adenosine monophosphate-activated protein kinase (AMPK) signaling pathway GF --+> mTORC2 complex mTORC2 complex --+> phosphatidylinositol 3-kinase-Akt signaling pathway Gator1 complex ---| Rrag members phosphatidylinositol 3-kinase-Akt signaling pathway ---| Akt1s1 adenosine monophosphate-activated protein kinase (AMPK) signaling pathway --+> Tsc2 Tsc2 ---| Rheb Akt1s1 ---| mTORC1 complex adenosine monophosphate-activated protein kinase (AMPK) signaling pathway ---| mTORC1 complex Fkbp1a ---- rapamycin rapamycin ---| mTORC1 complex arginine arginine ---- Gatsl3 Gatsl2 Gatsl2 ---- Gatsl3 Fkbp1a
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Genes in Pathway:


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mTOR signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO
IEA
PID
KEGG
PID:200096 rno:04150 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt1s1 AKT1 substrate 1 ISO PID
RGD
PMID:19339977 PMID:22500797 PID:200096, RGD:2308795, RGD:11535033 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:04150 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:04150 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
JBrowse link
G Atg13 autophagy related 13 ISO PID PID:200096 NCBI chr 3:77,647,069...77,681,028
Ensembl chr 3:77,645,790...77,681,043
JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO PID PID:200096 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO
IEA
PID
KEGG
PID:200096 rno:04150 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Cab39 calcium binding protein 39 IEA KEGG rno:04150 NCBI chr 9:86,463,095...86,524,545
Ensembl chr 9:86,463,095...86,524,544
JBrowse link
G Cab39l calcium binding protein 39-like IEA KEGG rno:04150 NCBI chr15:33,606,588...33,710,518
Ensembl chr15:33,606,694...33,743,545
JBrowse link
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 ISO RGD PMID:27015302 RGD:11535047 NCBI chr14:79,086,136...79,090,549
Ensembl chr14:79,086,136...79,090,548
JBrowse link
G Castor2 cytosolic arginine sensor for mTORC1 subunit 2 ISO RGD PMID:27015302 RGD:11535047 NCBI chr12:22,577,504...22,620,182
Ensembl chr12:22,577,512...22,620,182
JBrowse link
G Ccne1 cyclin E1 ISO PID PID:200096 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdk2 cyclin dependent kinase 2 ISO PID PID:200096 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 ISO PID PID:200096 NCBI chr12:32,910,932...33,017,891
Ensembl chr12:32,910,977...33,017,884
JBrowse link
G Cycs cytochrome c, somatic ISO PID PID:200096 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 ISO
IEA
PID
KEGG
PID:200096 rno:04150 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Depdc5 DEP domain containing 5, GATOR1 subcomplex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chr14:77,732,297...77,862,924
Ensembl chr14:77,732,297...77,862,794
JBrowse link
G Deptor DEP domain containing MTOR-interacting protein ISO PID
RGD
PMID:22500797 PID:200096, RGD:11535033 NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO PID PID:200096 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase ISO PID PID:200096 NCBI chr 1:175,393,119...175,456,756
Ensembl chr 1:175,393,154...175,455,164
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 ISO PID PID:200096 NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B ISO
IEA
PID
KEGG
PID:200096 rno:04150 NCBI chr 7:133,206,637...133,228,436 JBrowse link
G Eif4e eukaryotic translation initiation factor 4E ISO
IEA
PID
KEGG
PID:200096 rno:04150 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif4e2 eukaryotic translation initiation factor 4E family member 2 IEA KEGG rno:04150 NCBI chr 9:87,886,126...87,914,470
Ensembl chr 9:87,878,085...87,914,482
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 ISO
IEA
PID
KEGG
RGD
PMID:16885148 PMID:19339977 PID:200096 rno:04150, RGD:1625616, RGD:2308795 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Fbxw11 F-box and WD repeat domain containing 11 ISO PID PID:200096 NCBI chr10:17,232,735...17,330,574
Ensembl chr10:17,227,181...17,330,571
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO RGD PMID:22500797 RGD:11535033 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743
JBrowse link
G Flcn folliculin ISO RGD PMID:27076075 RGD:11535042 NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769
JBrowse link
G Fnip1 folliculin interacting protein 1 ISO RGD PMID:27076075 RGD:11535042 NCBI chr10:38,567,728...38,650,824
Ensembl chr10:38,567,729...38,650,824
JBrowse link
G Fnip2 folliculin interacting protein 2 ISO RGD PMID:27076075 RGD:11535042 NCBI chr 2:164,596,557...164,708,147
Ensembl chr 2:164,598,906...164,707,901
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEA KEGG rno:04150 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hras HRas proto-oncogene, GTPase ISO PID PID:200096 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Igf1 insulin-like growth factor 1 IEA KEGG rno:04150 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200096 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Ins1 insulin 1 IEA KEGG rno:04150 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Ins2 insulin 2 IEA KEGG rno:04150 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Irs1 insulin receptor substrate 1 ISO PID PID:200096 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 ISO RGD PMID:24698685 RGD:11535043 NCBI chr 1:156,272,116...156,277,687
Ensembl chr 1:156,272,064...156,291,179
JBrowse link
G Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 ISO RGD PMID:24698685 RGD:11535043 NCBI chr 2:174,008,556...174,011,950
Ensembl chr 2:174,008,548...174,013,013
JBrowse link
G Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 ISO RGD PMID:24698685 RGD:11535043 NCBI chr 2:226,411,389...226,423,612
Ensembl chr 2:226,411,400...226,423,607
JBrowse link
G Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 ISO RGD PMID:24698685 RGD:11535043 NCBI chr12:17,258,656...17,262,478
Ensembl chr12:17,258,623...17,262,480
JBrowse link
G Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 ISO RGD PMID:24698685 RGD:11535043 NCBI chr 2:194,900,038...194,905,394
Ensembl chr 2:194,900,038...194,905,395
JBrowse link
G Lpin1 lipin 1 IMP RGD PMID:11792863 RGD:1641823 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO PID PID:200096 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 ISO PID PID:200096 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO
IEA
PID
KEGG
PID:200096 rno:04150 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO
IEA
PID
KEGG
PID:200096 rno:04150 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapkap1 MAPK associated protein 1 ISO PID
RGD
PMID:19339977 PMID:22500797 PID:200096, RGD:2308795, RGD:11535033 NCBI chr 3:17,715,813...17,918,387
Ensembl chr 3:17,715,834...17,918,384
JBrowse link
G Mios meiosis regulator for oocyte development ISO RGD PMID:24698685 RGD:11535043 NCBI chr 4:36,263,419...36,289,546
Ensembl chr 4:36,263,968...36,289,544
JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog ISO
IEA
PID
KEGG
RGD
PMID:12718876 PMID:19339977 PMID:22500797 PID:200096 rno:04150, RGD:1626104, RGD:2308795, RGD:11535033 NCBI chr10:13,498,377...13,504,128
Ensembl chr10:13,498,388...13,504,128
JBrowse link
G Mtor mechanistic target of rapamycin kinase IDA
IMP
ISO
IEA
PID
KEGG
RGD
PMID:17142137 PMID:17142137 PMID:16885148 PMID:17110594 PMID:19339977 More... PID:200096 rno:04150, RGD:1625611, RGD:1625611, RGD:1625616, RGD:2307383, RGD:2308795, RGD:11535033 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nprl2 NPR2-like, GATOR1 complex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chr 8:108,215,823...108,218,996
Ensembl chr 8:108,215,814...108,218,996
JBrowse link
G Nprl3 NPR3-like, GATOR1 complex subunit ISO RGD PMID:24698685 RGD:11535043 NCBI chr10:15,355,361...15,395,812
Ensembl chr10:15,355,355...15,395,810
JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO PID PID:200096 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
JBrowse link
G Pdcd4 programmed cell death 4 ISO PID PID:200096 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO
IEA
PID
KEGG
PID:200096 rno:04150 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Pgf placental growth factor IEA KEGG rno:04150 NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IEA KEGG rno:04150 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:04150 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:04150 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:04150 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:04150 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:04150 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:04150 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374
JBrowse link
G Pld1 phospholipase D1 ISO PID PID:200096 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Pld2 phospholipase D2 ISO PID PID:200096 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Pml PML nuclear body scaffold ISO PID PID:200096 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Poldip3 DNA polymerase delta interacting protein 3 ISO PID PID:200096 NCBI chr 7:114,274,845...114,303,278
Ensembl chr 7:114,275,085...114,303,271
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO PID PID:200096 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 IEA KEGG rno:04150 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 IEA KEGG rno:04150 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Prkca protein kinase C, alpha ISO PID PID:200096 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prr5 proline rich 5 ISO PID
RGD
PMID:22500797 PID:200096, RGD:11535033 NCBI chr 7:115,795,351...115,837,880
Ensembl chr 7:115,813,954...115,834,834
JBrowse link
G Prr5l proline rich 5 like ISO RGD PMID:22500797 RGD:11535033 NCBI chr 3:88,001,951...88,173,532
Ensembl chr 3:88,003,617...88,082,763
JBrowse link
G Pxn paxillin ISO PID PID:200096 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931
JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID PID:200096 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO PID PID:200096 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 ISO PID PID:200096 NCBI chr 5:13,161,648...13,225,560
Ensembl chr 5:13,161,648...13,225,560
JBrowse link
G Rheb Ras homolog, mTORC1 binding IDA
ISO
IEA
PID
KEGG
RGD
PMID:16354680 PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 rno:04150, RGD:1625606, RGD:1625616, RGD:2308795, RGD:11535034 NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160
JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200096 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 ISO
IMP
IEA
PID
KEGG
RGD
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797 PID:200096 rno:04150, RGD:1625616, RGD:2307383, RGD:2308795, RGD:11535033 NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426
JBrowse link
G Rps6 ribosomal protein S6 IEA KEGG rno:04150 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 ISO
IEA
PID
KEGG
PID:200096 rno:04150 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272
JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 IEA KEGG rno:04150 NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739
JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 IEA KEGG rno:04150 NCBI chr  X:35,517,306...35,623,296
Ensembl chr  X:35,517,306...35,623,207
JBrowse link
G Rps6ka6 ribosomal protein S6 kinase A6 IEA KEGG rno:04150 NCBI chr  X:76,353,316...76,454,502
Ensembl chr  X:76,353,760...76,454,484
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO
IMP
IEA
PID
KEGG
RGD
PMID:16885148 PMID:11574531 PMID:19339977 PID:200096 rno:04150, RGD:1625616, RGD:1626103, RGD:2308795 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 ISO
IMP
IEA
KEGG
RGD
PMID:16885148 PMID:11574531 PMID:19339977 rno:04150, RGD:1625616, RGD:1626103, RGD:2308795 NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078
JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 ISO
IMP
IEA
PID
KEGG
RGD
PMID:16885148 PMID:17110594 PMID:19339977 PMID:22500797 PID:200096 rno:04150, RGD:1625616, RGD:2307383, RGD:2308795, RGD:11535033 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983
JBrowse link
G Rraga Ras-related GTP binding A ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096, RGD:2308795, RGD:11535043 NCBI chr 5:101,113,341...101,114,936
Ensembl chr 5:101,112,859...101,114,510
JBrowse link
G RragB Ras-related GTP binding B ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096, RGD:2308795, RGD:11535043 NCBI chr  X:18,184,619...18,234,639
Ensembl chr  X:18,184,992...18,234,639
JBrowse link
G Rragb_v1 Ras-related GTP binding B, variant 1 ISO RGD PMID:19339977 RGD:2308795
G Rragc Ras-related GTP binding C ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096, RGD:2308795, RGD:11535043 NCBI chr 5:136,148,239...136,167,773
Ensembl chr 5:136,148,276...136,167,767
JBrowse link
G Rragd Ras-related GTP binding D ISO PID
RGD
PMID:19339977 PMID:24698685 PID:200096, RGD:2308795, RGD:11535043 NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356
JBrowse link
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor ISO PID PID:200096 NCBI chr10:2,129,949...2,165,381
Ensembl chr10:2,129,978...2,165,663
JBrowse link
G Sesn2 sestrin 2 ISO RGD PMID:27076075 RGD:11535042 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Sfn stratifin ISO PID PID:200096 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 ISO PID PID:200096 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Slc7a5 solute carrier family 7 member 5 IMP RGD PMID:25049270 RGD:151361107 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 ISO PID PID:200096 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Sspo SCO-spondin ISO PID PID:200096 NCBI chr 4:77,394,915...77,450,526
Ensembl chr 4:77,397,059...77,450,412
JBrowse link
G Stk11 serine/threonine kinase 11 IEA KEGG rno:04150 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Strada STE20 related adaptor alpha IEA KEGG rno:04150 NCBI chr10:91,094,849...91,123,890
Ensembl chr10:91,094,687...91,123,830
JBrowse link
G Tbc1d7 TBC1 domain family, member 7 ISO RGD PMID:26159692 RGD:11535034 NCBI chr17:21,530,709...21,548,556
Ensembl chr17:21,531,016...21,548,553
JBrowse link
G Telo2 telomere maintenance 2 ISO RGD PMID:22500797 RGD:11535033 NCBI chr10:14,120,491...14,135,729
Ensembl chr10:14,120,818...14,135,698
JBrowse link
G Tsc1 TSC complex subunit 1 ISO
IEA
PID
KEGG
RGD
PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 rno:04150, RGD:1625616, RGD:2308795, RGD:11535034 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674
JBrowse link
G Tsc2 TSC complex subunit 2 IDA
ISO
IEA
PID
KEGG
RGD
PMID:12869586 PMID:16885148 PMID:19339977 PMID:26159692 PID:200096 rno:04150, RGD:1580520, RGD:1625616, RGD:2308795, RGD:11535034 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link
G Tsc2_v1 TSC complex subunit 2, variant 1 ISO RGD PMID:16885148 RGD:1625616
G Tsc2_v2 TSC complex subunit 2, variant 2 ISO RGD PMID:16885148 RGD:1625616
G Tti1 TELO2 interacting protein 1 ISO RGD PMID:22500797 RGD:11535033 NCBI chr 3:146,639,048...146,682,945
Ensembl chr 3:146,639,054...146,682,847
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 ISO
IEA
PID
KEGG
PID:200096 rno:04150 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link
G Ulk2 unc-51 like autophagy activating kinase 2 ISO
IEA
PID
KEGG
PID:200096 rno:04150 NCBI chr10:46,451,578...46,530,462
Ensembl chr10:46,454,030...46,530,407
JBrowse link
G Ulk3 unc-51 like kinase 3 IEA KEGG rno:04150 NCBI chr 8:57,992,396...58,000,220
Ensembl chr 8:57,992,723...57,999,467
JBrowse link
G Vegfa vascular endothelial growth factor A IEA KEGG rno:04150 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vegfb vascular endothelial growth factor B IEA KEGG rno:04150 NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944
JBrowse link
G Vegfc vascular endothelial growth factor C IEA KEGG rno:04150 NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848
JBrowse link
G Vegfd vascular endothelial growth factor D IEA KEGG rno:04150 NCBI chr  X:30,073,122...30,108,413
Ensembl chr  X:30,074,163...30,108,295
JBrowse link
G Wdr24 WD repeat domain 24 ISO RGD PMID:24698685 RGD:11535043 NCBI chr10:14,844,089...14,848,871
Ensembl chr10:14,843,728...14,848,864
JBrowse link
G Wdr59 WD repeat domain 59 ISO RGD PMID:24698685 RGD:11535043 NCBI chr19:39,416,432...39,483,773
Ensembl chr19:39,416,429...39,483,698
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta ISO PID PID:200096 NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon ISO PID PID:200096 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma ISO PID PID:200096 NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta ISO PID PID:200096 NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta ISO PID PID:200096 NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta ISO PID PID:200096 NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668
JBrowse link
G Yy1 YY1 transcription factor ISO PID PID:200096 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747
JBrowse link

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene GroupRrag membersA protein family that mediates mTorc1 activation
ComplexmTORC1 complexmTOR complex 1
ComplexmTORC2 complexmTOR complex 2

Pathway Gene Annotations

Disease Annotations Associated with Genes in the mTOR signaling pathway
Disease TermsGene Symbols
16Q24.3 Microdeletion SyndromeSlc7a5
3-methylglutaconic aciduria type 7bLamtor1
abdominal obesity-metabolic syndromePpargc1a
Aberrant Crypt FociMapk1 , Mapk3
Abnormal ReflexesIns1
Abnormalities, Drug-InducedRhoa
acneIgf1
acoustic neuromaIgf1 , Vegfa
acromegalyIgf1
acute chest syndromeVegfa
Acute HepatitisTsc2
acute kidney failureHif1a , Igf1 , Ins2 , Mtor , Ppargc1a , Vegfa
Acute Liver FailureIns1 , Ins2
Acute Lung InjuryAkt1 , Prkaa1 , Vegfa
acute lymphoblastic leukemiaNras
acute myeloid leukemiaEif4ebp1 , Hras , Nras , Sgk1 , Tsc1 , Tsc2 , Vegfa
acute myocardial infarctionRhoa
acute promyelocytic leukemiaAkt1 , Nras , Pml
Acute Recurrent Myoglobinuria, Autosomal RecessiveLpin1
Acute-Phase ReactionHif1a
adenocarcinomaAkt1 , Akt2 , Eef2 , Mtor , Pik3ca , Stk11 , Vegfa
adenoid cystic carcinomaHras , Map2k2 , Pik3ca , Slc7a5
adenomaIgf1 , Ins2
adenosine deaminase deficiencyYwhab
adhesions of uterusVegfa
adrenocortical carcinomaBraf , Nras , Pik3ca
adult T-cell leukemia/lymphomaNras
adult-onset Still's diseaseVegfa
agammaglobulinemia 7Pik3r1
age related macular degenerationPpargc1a
Agenesis of Corpus CallosumPik3ca
Aicardi-Goutieres Syndrome 1Rhoa
Aicardi-Goutieres Syndrome 3Rps6kb2
AIDS Dementia ComplexIrs1
AIDS-Associated NephropathyMtor
AlbuminuriaIgf1 , Ins2 , Ppargc1a
alcohol dependenceMapk1 , Mapk3
alcohol use disorderMapk1 , Mapk3
alcoholic hepatitisAkt1 , Mtor , Srebf1
Alcoholic Liver DiseasesAkt1 , Hif1a , Mtor , Vegfa
alcoholic neuropathyIgf1
allergic contact dermatitisSlc7a5 , Vegfa
alopeciaIgf1 , Rhoa
Alzheimer's diseaseAkt1 , Eef2 , Eef2k , Hif1a , Hras , Igf1 , Ikbkb , Ins1 , Ins2 , Irs1 , Mapk1 , Mapk3 , Pik3r1 , Ppargc1a , Tsc2 , Vegfa
amblyopiaPpargc1a
ameloblastomaBraf
amenorrheaEef2 , Map2k2 , Prkaa1
amnestic disorderPpargc1a
amphetamine abuseAkt1
amyotrophic lateral sclerosisAkt1 , Pgf , Ppargc1a , Vegfa
amyotrophic lateral sclerosis type 1Vegfa
AnaplasiaHif1a
anemiaNras
angiomyolipomaTsc2
angiosarcomaHras , Vegfa , Vegfc
Animal Disease ModelsAkt1 , Mapk1 , Mapk3 , Rhoa
Animal Mammary NeoplasmsHras , Ins1 , Pik3r1 , Sgk1 , Ywhaz
ankylosing spondylitisPgf
anterior segment dysgenesisTsc1
Aortic Aneurysm, Giant CongenitalBraf
Arterial InjuryPdcd4
Arterial ThrombosisHif1a
arteriosclerosisIgf1
Arteriovenous FistulaVegfa
arteriovenous malformationPik3ca
arteriovenous malformations of the brainBraf , Vegfa
ArthralgiaTsc2
AsphyxiaHif1a
asthmaHif1a , Pgf , Rhoa , Vegfa
astroblastomaPik3r1
astroblastoma, MN1-alteredTsc2
ataxia telangiectasiaBraf
ataxia with oculomotor apraxia type 3Pik3r5
atherosclerosisAkt1 , Mtor , Pgf , Srebf1 , Vegfa , Vegfc
atrial fibrillationHif1a , Vegfa
AtrophyMapk3 , Rps6kb1
attention deficit hyperactivity disorderVegfa
autism spectrum disorderEif4a1 , Eif4b , Eif4e , Map2k1 , Mapk1 , Mapk3 , Mtor , Rps6ka2 , Slc7a5 , Tsc1 , Tsc2
autistic disorderEef2k , Eif4e , Flcn , Hras , Igf1 , Lamtor5 , Mapk3 , Rb1cc1 , Rps6ka3 , Rps6ka6 , RragB , Rrn3 , Srebf1 , Tsc1 , Tsc2 , Ulk2 , Vegfd
autoimmune hepatitisHras , Vegfa
autoimmune lymphoproliferative syndromeNras
autoimmune lymphoproliferative syndrome type 4Nras
autosomal dominant intellectual developmental disorder 48Rac1
autosomal dominant nocturnal frontal lobe epilepsyDepdc5 , Mtor , Tsc1
autosomal dominant polycystic kidney diseaseMlst8 , Mtor , Rps6kb1
autosomal recessive chronic granulomatous disease 4Slc7a5
autosomal recessive limb-girdle muscular dystrophy type 2PRhoa
autosomal recessive nonsyndromic deafness 111Igf1
autosomal recessive polycystic kidney diseaseAkt1 , Mtor , Pik3ca , Tsc1
autosomal recessive spinocerebellar ataxia 16Wdr24
B-Cell Chronic Lymphocytic LeukemiaBraf , Hras , Nras
B-cell lymphomaNras
B-lymphoblastic leukemia/lymphomaStk11
bacterial pneumoniaPgf
Bannayan-Riley-Ruvalcaba syndromePik3ca
Bardet-Biedl syndromeAkt3 , Pml , Ulk3
Bardet-Biedl syndrome 16Akt3
Barth syndromeFkbp1a
basal cell carcinomaPik3ca
Beckwith-Wiedemann syndromeHras , Ins1 , Ins2
Behcet's diseaseVegfa
benign epilepsy with centrotemporal spikesDepdc5 , Strada
benign familial infantile seizures 6Depdc5
bile duct adenocarcinomaSlc7a5
bile duct adenomaBraf
bile duct cancerStk11
bile duct carcinomaSlc7a5
bipolar disorderAkt1 , Ins2 , Rps6ka2
Birt-Hogg-Dube syndromeFlcn , Srebf1
bladder carcinomaHras
bladder diseaseIns2
bladder exstrophy-epispadias-cloacal exstrophy complexFlcn
bladder neck obstructionHif1a
blindnessVegfa
Bloom syndromeMap2k1 , Pml , Ulk3
bone development diseaseRps6ka3
bone osteosarcomaAkt1 , Tsc2
borna diseaseIgf1
Bowen's DiseaseCcne1 , Ppargc1a
BradycardiaIns1
brain cancerStk11
brain diseaseTsc1 , Tsc2
brain edemaVegfa
brain glioblastoma multiformeEef2
brain gliomaVegfa
Brain Hypoxia-IschemiaHif1a , Igf1 , Vegfa
brain infarctionHif1a
Brain InjuriesAkt1 , Igf1 , Ppargc1a , Rhoa , Vegfa , Vegfb
brain ischemiaAkt1 , Cycs , Hif1a , Igf1 , Map2k1 , Mapk1 , Mapk3 , Pgf , Prkca , Ywhab
Brain NeoplasmsBraf , Hras , Nras , Pik3ca , Pik3r1 , Stk11 , Tsc2 , Vegfa
breast adenocarcinomaAkt1 , Ccne1 , Pik3ca , Rb1cc1
breast angiosarcomaPik3ca
breast cancerAkt1 , Ccne1 , Cdk2 , Igf1 , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Pgf , Pik3ca , Prkaa1 , Rac1 , Rb1cc1 , Rhoa , Stk11 , Tsc1 , Tsc2
Breast Cancer, FamilialAkt1 , Pik3ca , Pik3r3 , Rb1cc1
breast carcinomaPik3ca , Rhoa , Stk11 , Vegfc
breast ductal carcinomaPml , Rictor
Breast NeoplasmsAkt1 , Akt2 , Braf , Ccne1 , Eef2 , Hif1a , Hras , Igf1 , Lamtor5 , Mtor , Pdpk1 , Pik3ca , Pik3r1 , Prkca , Raf1 , Rb1cc1 , Rhoa , Rps6 , Rps6kb2 , Vegfa , Vegfb , Vegfc
bronchopulmonary dysplasiaHif1a
Brugada syndrome 8Pml , Ulk3
bullous pemphigoidVegfa
Burkitt lymphomaPik3r1
BurnsHif1a , Igf1 , Mtor , Rps6kb1
CachexiaIgf1 , Lpin1
Cafe-au-Lait SpotsTsc2
Calcification of Aortic ValveAkt1
cancerBraf
cannabis abuseAkt1
capillary hemangiomaAkt3
Capillary Malformation-Arteriovenous Malformation 1Pik3ca
CARBONIC ANHYDRASE VA DEFICIENCY, HYPERAMMONEMIA DUE TOSlc7a5
CarcinogenesisAkt1 , Braf
carcinomaHif1a , Hras , Pik3r1 , Rhoa , Sgk1 , Ywhaz
cardiac arrestAkt1 , Ins2
Cardiac FibrosisPrkaa2
cardiofaciocutaneous syndromeBraf , Hras , Map2k1 , Map2k2
cardiofaciocutaneous syndrome 1Braf , Map2k2
cardiofaciocutaneous syndrome 3Map2k1
cardiofaciocutaneous syndrome 4Map2k2
CardiomegalyAkt1 , Hif1a , Igf1 , Mapk1 , Mtor , Pld1 , Pld2 , Ppargc1a , Prkaa2 , Prkca , Rac1 , Raf1 , Rhoa , Rps6kb1 , Stk11 , Vegfa , Yy1
cardiomyopathyAkt1 , Braf , Mapk1 , Mapk3 , Ppargc1a , Prkaa2 , Vegfa , Ywhah
CardiotoxicityPrkaa2 , Rac1
Cardiovascular AbnormalitiesMap2k1 , Pik3ca
cardiovascular system diseasePpargc1a
carnitine-acylcarnitine translocase deficiencyRhoa
carotid artery diseaseIgf1 , Pgf
Carotid Artery InjuriesIgf1 , Ppargc1a
Carpenter Syndrome 2Akt2
cataractMap2k1
CEBALID SyndromeMtor
cerebellar ataxia type 48Wdr24
Cerebral Cavernous Malformation 4Pik3ca
cerebral creatine deficiency syndromeStk11
cerebral folate receptor alpha deficiencyLamtor1
Cerebral HemorrhageMtor , Vegfa
cerebral infarctionHif1a
cerebral malariaPrkaa2
cervical cancerNras
cervical mucinous adenocarcinomaStk11
cervix uteri carcinoma in situCcne1 , Vegfa
Chanarin-Dorfman syndromeHras
Charcot-Marie-Tooth disease axonal type 2OAkt1
Charcot-Marie-Tooth disease dominant intermediate CPik3r3 , Rragc
Charcot-Marie-Tooth disease type 2Lamtor2 , Mtor , Pik3cd
Chemical and Drug Induced Liver InjuryIgf1 , Prkaa1 , Sesn2 , Slc7a5 , Vegfa
childhood absence epilepsyYwhaz
childhood pilocytic astrocytomaMapk1
Chlamydia pneumoniaPik3cd
ChloracneCycs
cholangiocarcinomaBraf , Cycs , Hif1a , Ins2 , Slc7a5 , Vegfa
cholangitisNras
cholestasisIgf1 , Prkaa1
cholesteatomaVegfa
cholesteatoma of middle earHif1a , Vegfa
chondrosarcomaMtor
chordoid gliomaPrkca
Choroidal NeovascularizationHif1a , Ikbkb , Vegfa , Vegfb
chromosome 13q14 deletion syndromeCab39l
chromosome 16p11.2 deletion syndrome, 593-kbMapk3
chromosome 16p11.2 duplication syndromeMapk3
chromosome 16p12.1 deletion syndromeEef2k
chromosome 17p13.3 duplication syndromeYwhae
chromosome 1p36 deletion syndromeMtor , Pik3cd
chromosome 22q11.2 deletion syndrome, distalMapk1
Chromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MBYwhag
Chronic Allograft DysfunctionMtor
Chronic BronchitisVegfa
Chronic Cerebral HypoperfusionHif1a
chronic fatigue syndromeVegfa
Chronic Intermittent HypoxiaBnip3 , Hif1a , Vegfa
chronic kidney diseasePpargc1a
chronic lymphocytic leukemiaBraf , Hras , Nras
chronic myelogenous leukemia, BCR-ABL1 positiveBraf , Nras
chronic myeloid leukemiaAkt1 , Braf , Nras , Vegfa
chronic myelomonocytic leukemiaNras
chronic obstructive pulmonary diseaseBnip3 , Hif1a , Ppargc1a , Vegfa
CLAPO SyndromePik3ca
clear cell renal cell carcinomaPml , Vegfa
Closed Head InjuriesIgf1
CLOVES syndromePik3ca , Pik3r1
cocaine abuseMapk1 , Mapk3
cocaine dependenceMapk1 , Mapk3
Cocaine-Related DisordersMapk1 , Mapk3 , Rhoa
Cockayne syndromeIgf1
Coffin-Lowry syndromeRps6ka3
cognitive disorderIns2 , Tsc1
Cohen syndromeYwhaz
colitisIgf1 , Ikbkb , Pgf , Ppargc1a
colon adenocarcinomaEef2 , Mapk1 , Mapk3 , Pik3ca , Pik3r3 , Rac1 , Vegfc
colon adenomaRac1
colon cancerAkt1 , Akt3 , Ikbkb , Mapk1 , Mtor , Pik3r2 , Pik3r5 , Prkaa1 , Rictor , Rps6kb1 , Slc7a5 , Vegfa
colon carcinomaAkt1 , Braf , Flcn , Nras , Pik3ca , Stk11 , Vegfa
Colonic NeoplasmsBraf , Ccne1 , Hif1a , Mtor , Pik3r1 , Pik3r2 , Vegfa
colorectal adenocarcinomaBraf , Mapk1 , Mapk3 , Rac1 , Raf1 , Rictor , Slc7a5
colorectal adenomaRaf1
colorectal cancerAkt1 , Akt2 , Braf , Eef2 , Flcn , Hif1a , Ins1 , Map2k1 , Map2k2 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pml , Rac1 , Rhoa , Rictor , Slc7a5 , Ulk3 , Vegfa
colorectal carcinomaPik3ca , Rac1
Colorectal NeoplasmsAkt1 , Akt2 , Braf , Flcn , Hras , Map2k1 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3r1 , Pik3r3 , Raf1 , Rhoa , Sesn2
common variable immunodeficiencyEif4a1
common variable immunodeficiency 2Flcn , Srebf1
common variable immunodeficiency 4Poldip3
complex cortical dysplasia with other brain malformationsAkt3 , Hras , Mtor , Pik3ca , Tsc1
congenital diaphragmatic herniaIgf1 , Rhoa , Vegfa
congenital disorder of glycosylation IaIgf1
congenital disorder of glycosylation type IIcAtg13
congenital fibrosis of the extraocular musclesHras
congenital heart diseaseFkbp1a , Hif1a , Mapk1 , Vegfa
congenital hypoplastic anemiaAkt2
congenital hypothyroidismIgf1 , Ppargc1a
congenital myasthenic syndrome 2AEif4a1
Congenital Myopathy with Excess of Muscle SpindlesHras
congestive heart failureBnip3 , Hif1a , Igf1 , Ins2 , Map2k1 , Mtor , Pdpk1 , Pgf , Pld2 , Ppargc1a , Prkca , Rac1 , Vegfa , Yy1
ConstipationYwhag
contact dermatitisVegfa
corneal diseaseIgf1
corneal neovascularizationVegfa
Cornelia de Lange syndrome 3Pdcd4
coronary artery diseaseAkt1 , Irs1 , Srebf1 , Vegfa
Coronary DiseaseIgf1 , Irs1 , Vegfa
coronary restenosisMapk1
coronary stenosisIgf1
Coronavirus infectious diseaseMapk1 , Mapk3
coronin-1A deficiencyMapk3 , Nras
Costello syndromeBraf , Hras , Map2k1 , Map2k2
COVID-19Akt3 , Ddit4 , Eef2 , Sgk1 , Vegfa , Ywhag
Cowden syndromePik3ca
Cowden syndrome 5Pik3ca
Cowden syndrome 6Akt1
Craniofacial AbnormalitiesRhoa
craniopharyngiomaBraf , Tsc1
craniosynostosisAkt2
crescentic glomerulonephritisMtor
Creutzfeldt-Jakob diseaseYwhag
Crohn's diseaseIgf1 , Pgf , Vegfa
Cronkhite-Canada syndromeStk11
Currarino syndromePik3ca
cutaneous leishmaniasisPik3cd
cutaneous Paget's diseasePik3ca
cyclic hematopoiesisStk11
cystic fibrosisIgf1
cystic kidney diseaseIns2
CystsFlcn
Dandy-Walker syndromeBraf
DeafnessIgf1
decubitus ulcerHif1a , Vegfa
DehydrationYwhaz
delta beta-thalassemiaHras , Ins1 , Ins2
demyelinating diseaseIgf1 , Mapk1
depressive disorderIgf1 , Ins1 , Mapk1
dermatitisIkbkb
dermatitis herpetiformisVegfa
developmental and epileptic encephalopathyHras , Ins1 , Ins2 , Nprl2 , Pik3r3 , Tsc1
developmental and epileptic encephalopathy 1Mlst8 , Pdpk1 , Tsc2
Developmental and Epileptic Encephalopathy 111Depdc5
developmental and epileptic encephalopathy 12Akt1s1
developmental and epileptic encephalopathy 14Tsc1
developmental and epileptic encephalopathy 2Rps6ka3
developmental and epileptic encephalopathy 32Lamtor5
developmental and epileptic encephalopathy 54Akt3
developmental and epileptic encephalopathy 56Ywhag
developmental and epileptic encephalopathy 70Tbc1d7
developmental and epileptic encephalopathy 83Depdc5
developmental cardiac valvular defectPld1
developmental coordination disorderRptor
Developmental Delay with Variable Intellectual Impairment and Behavioral AbnormalitiesPoldip3
Developmental DisabilitiesAkt3 , Braf , Clip1 , Depdc5 , Mapk3 , Pik3ca , Pik3r2 , Rac1 , Rps6ka3
Developmental DiseaseDepdc5 , Rac1
Diabetes ComplicationsHif1a , Prkaa1 , Vegfa
diabetes mellitusIgf1 , Ins1 , Ins2 , Irs1 , Rac1
Diabetes Mellitus, New-Onset after TransplantationMtor
diabetic angiopathyVegfa
Diabetic CardiomyopathiesAkt1 , Igf1 , Ins1 , Ins2 , Mapk1 , Mapk3 , Mtor , Pik3ca
Diabetic FootHif1a , Igf1
diabetic ketoacidosisIns2
Diabetic NephropathiesCcne1 , Hif1a , Igf1 , Ins2 , Mapk1 , Mtor , Pgf , Ppargc1a , Rhoa , Srebf1 , Vegfa , Yy1
diabetic neuropathyIgf1 , Pgf , Sgk1 , Srebf1 , Vegfa
diabetic retinopathyAkt1 , Hif1a , Hras , Igf1 , Ins2 , Pgf , Ppargc1a , Vegfa
Diamond-Blackfan anemiaAkt2
diaphragmatic eventrationPik3ca
Diaphragmatic HerniaIgf1
diffuse large B-cell lymphomaBraf , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Rps6kb1
DiGeorge syndromeMapk1 , Vegfa
dilated cardiomyopathyBraf , Igf1 , Mapk3 , Pgf , Ppargc1a , Prkca , Rac1 , Raf1 , Rps6kb1
dilated cardiomyopathy 1BRaf1
dilated cardiomyopathy 1DDPdcd4
dilated cardiomyopathy 1NNRaf1
Dilated Cardiomyopathy with Left Ventricular NoncompactionRaf1
disease of cellular proliferationBraf , Hras , Map2k1 , Nras , Pik3ca , Pik3r1 , Stk11 , Vegfa , Yy1
disease of metabolismIns2 , Srebf1
Disease ProgressionCcne1 , Hif1a , Hras , Pik3ca , Rps6 , Slc7a5 , Vegfb , Yy1
Diseases of the AgedPpargc1a
distal 10q deletion syndromeBnip3
Distal Arthrogryposis, with Impaired Proprioception and TouchStk11
Down syndromePik3ca
Drug-Induced DyskinesiaMtor
Drug-Related Side Effects and Adverse ReactionsIgf1 , Vegfa
Ductal CarcinomaHif1a
ductal carcinoma in situBnip3 , Hif1a , Prkca , Vegfa
duodenal ulcerVegfa
DwarfismClip1 , Igf1 , Map2k2 , Mapk1
dysembryoplastic neuroepithelial tumorBraf
dyskeratosis congenitaEif4a1
DyslipidemiasPml
dysplastic nevus syndromeBraf , Stk11
early infantile epileptic encephalopathyHras , Ins1 , Ins2 , Nprl2 , Pik3r3 , Tsc1
ectodermal dysplasiaRhoa
ECTODERMAL DYSPLASIA WITH FACIAL DYSMORPHISM AND ACRAL, OCULAR, AND BRAIN ANOMALIESRhoa
EdemaIns2
Ehlers-Danlos syndrome classic type 1Tsc1
Embryo LossCdk2
embryonal rhabdomyosarcomaStk11
end stage renal diseaseBnip3 , Igf1 , Irs1 , Lpin1 , Mtor , Pgf , Srebf1
endocrine system diseaseMtor
endometrial adenocarcinomaMapk1 , Mapk3 , Pik3r1
endometrial cancerAkt2 , Pik3cb , Pik3cd , Pik3r1 , Stk11
endometrial carcinomaBraf , Hras , Mapk1 , Mapk3 , Mlst8 , Pik3ca , Pik3r1 , Prkca , Sfn , Stk11 , Tsc2
Endometrial NeoplasmsCdk2 , Mapk3 , Pik3ca , Pik3cb , Vegfa
Endometrioid CarcinomasAkt1 , Ccne1 , Cdk2 , Mapk1 , Mapk3 , Pik3r2
endometriosisIgf1 , Vegfa
EndotoxemiaAkt1 , Igf1 , Irs1 , Pgf , Prkaa1 , Slc7a5
epidermal nevusHras , Nras , Pik3ca
epilepsyAkt1 , Depdc5 , Mlst8 , Mtor , Nprl2 , Nprl3 , Pdpk1 , Pgf , Pik3r2 , Rheb , Rrn3 , Strada , Telo2 , Tsc1 , Tsc2 , Wdr24 , Ywhag
Episodic Kinesigenic DyskinesiaMapk3
episodic kinesigenic dyskinesia 1Mapk3
erythema multiformeVegfa
esophageal cancerAkt1 , Pik3ca
esophageal carcinomaAkt1 , Hras , Pik3ca , Rhoa , Slc7a5
Esophageal NeoplasmsSfn
esophagitisSlc7a5
esophagus adenocarcinomaPik3ca
esophagus squamous cell carcinomaAkt1 , Fkbp1a , Hif1a , Rictor , Sfn , Slc7a5
estrogen-receptor positive breast cancerPik3ca
exocrine pancreatic insufficiencyMtor
Experimental ArthritisAkt1 , Hif1a , Igf1 , Ikbkb , Mtor , Nras , Pgf , Pik3cd , Vegfa
Experimental Autoimmune EncephalomyelitisIgf1 , Prkaa1 , Rhoa , Vegfa
Experimental Autoimmune MyocarditisRps6
Experimental Autoimmune NeuritisHif1a , Rhoa
Experimental ColitisAkt1 , Mapk1 , Mapk3 , Vegfa
Experimental Diabetes MellitusAkt1 , Eef2 , Hif1a , Hras , Igf1 , Ikbkb , Ins1 , Irs1 , Lpin1 , Mapk1 , Mapk3 , Mtor , Pgf , Pik3r1 , Ppargc1a , Prkaa2 , Prkca , Rhoa , Srebf1 , Tsc2 , Vegfa , Vegfb , Ywhah
Experimental LeukemiaNras
Experimental Liver CirrhosisAkt1 , Cdk2 , Fkbp1a , Igf1 , Ins2 , Mapk1 , Mapk3 , Mtor , Pgf , Rhoa , Srebf1 , Vegfa , Ywhag , Ywhaz
Experimental Liver NeoplasmsHras , Map2k1 , Mapk1 , Mapk3 , Nras , Pml , Slc7a5
Experimental Mammary NeoplasmsAkt1 , Akt2 , Ccne1 , Cdk2 , Hif1a , Hras , Igf1 , Mapk1 , Mapk3 , Mtor , Pik3r1 , Sgk1 , Vegfa , Ywhaz
Experimental MelanomaBraf , Ikbkb , Pxn
Experimental NeoplasmsBraf , Hif1a , Hras , Nras , Rictor , Vegfa
Experimental Radiation InjuriesHif1a , Mapk1 , Mapk3
Experimental SarcomaNras
extrahepatic bile duct adenocarcinomaRac1 , Slc7a5
extrahepatic cholestasisMapk1 , Mapk3
extrinsic allergic alveolitisVegfa
Facial AsymmetryPik3ca
Failure to ThriveYwhag
familial adenomatous polyposisAkt1 , Stk11
familial adenomatous polyposis 1Fnip1 , Stk11
familial adenomatous polyposis 2Stk11
familial adenomatous polyposis 3Tsc2
Familial Atrial Fibrillation 6Mtor
familial focal epilepsy with variable fociDepdc5 , Nprl2
familial focal epilepsy with variable foci 1Depdc5 , Nprl2 , Nprl3
familial focal epilepsy with variable foci 2Nprl2
familial focal epilepsy with variable foci 3Nprl3
familial hyperlipidemiaIrs1 , Srebf1
familial hypertrophic cardiomyopathyRaf1
familial Mediterranean feverIgf1
familial melanomaBraf , Stk11
familial multiple nevi flammeiPik3ca
familial partial lipodystrophyAkt2
Familial Prostate CancerMap2k1
Fanconi anemiaSlc7a5 , Vegfd
Fanconi-Bickel syndromePld1
Female InfertilityMapk1 , Mapk3 , Tsc2
Female Urogenital DiseasesIgf1
Femur Head NecrosisHif1a
fetal alcohol spectrum disorderIgf1 , Rps6ka1
fetal alcohol syndromeRhoa
Fetal Growth RetardationIgf1 , Irs1 , Ppargc1a , Srebf1
Fetal MacrosomiaIgf1
FeverTsc2
FibrosisAkt1 , Rhoa
Focal Cortical Dysplasia of TaylorMtor , Tsc1 , Tsc2
Focal Cortical Dysplasia of Taylor, Type IIBTsc1
focal epilepsyNprl3 , Nras , Tti1 , Ywhab
focal segmental glomerulosclerosis 5Akt1
folic acid deficiency anemiaIgf1
follicular lymphomaRragc
Follicular Thyroid CancerBraf , Hras , Nras
GABRIELE-DE VRIES SYNDROMEYy1
gallbladder cancerBraf , Pik3ca , Rictor
gallbladder carcinomaPik3ca , Rac1
gangliogliomaBraf
gastric adenocarcinomaAkt1 , Braf , Hras , Map2k1 , Map2k2 , Mtor , Nras , Pik3ca , Rac1 , Raf1 , Rhoa , Slc7a5
gastric ulcerMapk1 , Mapk3 , Vegfa
Gastrointestinal NeoplasmsPik3ca
gastrointestinal stromal tumorAkt3 , Braf , Lamtor2
generalized dystoniaIns2
genetic diseaseAkt1 , Akt2 , Akt3 , Braf , Depdc5 , Fnip1 , Hras , Igf1 , Ikbkb , Ins1 , Ins2 , Lpin1 , Map2k1 , Mapk1 , Mtor , Nprl2 , Nprl3 , Pik3ca , Pik3cd , Pik3r1 , Pik3r2 , Pld1 , Rac1 , Raf1 , Rhoa , Rictor , Rps6ka3 , Rragc , Rragd , Srebf1 , Strada , Telo2 , Tsc2 , Tti1 , Vegfc , Ywhag , Yy1
Germ Cell and Embryonal NeoplasmsCcne1 , Rhoa
germinomaBraf
gestational diabetesIns2
gingivitisVegfa
glaucomaEef2 , Vegfa
glioblastomaAkt1 , Akt3 , Braf , Hif1a , Hras , Map2k2 , Mtor , Nras , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pml , Slc7a5 , Vegfa
gliosarcomaVegfa
GliosisMapk1 , Mapk3
glomerulonephritisMapk1 , Vegfa
Glomus Tympanicum TumorVegfa
glucose intoleranceIkbkb , Ins2 , Lamtor5 , Pik3r1 , Ppargc1a , Prkaa1 , Prkaa2
glycine encephalopathyRhoa
glycogen storage disease IIPik3ca
glycogen storage disease IIIIgf1
glycogen storage disease IXARps6ka3
glycogen storage disease VHif1a
glycogen storage disease VIIHif1a
Glycogen Storage Disease XIIMapk3
graft-versus-host diseaseVegfa
granulomatosis with polyangiitisIgf1
granulosa cell tumorSgk1 , Vegfa
Graves ophthalmopathyIgf1
Graves' diseaseIgf1 , Vegfa
Growth DisordersIgf1 , Pik3ca
Habitual AbortionsCdk2
hairy cell leukemiaMap2k1
HamartomaFlcn , Tsc2
head and neck cancerPik3ca
Head and Neck NeoplasmsMapk1 , Mapk3 , Pik3ca , Vegfa
head and neck squamous cell carcinomaAkt1 , Braf , Ccne1 , Cdk2 , Hras , Igf1 , Irs1 , Map2k1 , Map2k2 , Mapk1 , Pik3ca , Rac1 , Rhoa , Stk11
Hearing Loss, Noise-InducedHif1a , Igf1
heart diseasePpargc1a , Vegfa
Helicobacter InfectionsPrkaa1
hemangioblastomaHif1a
hemangiomaTsc2
Hemifacial MyohyperplasiaPik3ca
HemimegalencephalyMtor , Pik3ca , Rheb , Rps6
HemorrhageBnip3 , Vegfa
hemorrhagic diseaseCycs
Hemorrhagic ShockMapk1 , Mtor
Henoch-Schoenlein purpuraIgf1
hepatic angiomyolipomaTsc2
hepatic encephalopathyHif1a
hepatitisCcne1 , Ins2
hepatoblastomaFlcn , Stk11
hepatocellular adenomaHras
hepatocellular carcinomaAkt1 , Akt2 , Braf , Cab39 , Ccne1 , Depdc5 , Eef2 , Hif1a , Hras , Igf1 , Ins1 , Ins2 , Irs1 , Map2k2 , Mapk1 , Mtor , Nras , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Pik3r3 , Pml , Rac1 , Rictor , Rps6 , Rps6ka3 , Sfn , Slc7a5 , Srebf1 , Tsc1 , Tsc2 , Vegfa , Vegfc , Ywhaz
HepatomegalyAkt1 , Mtor , Sesn2
hepatopulmonary syndromeVegfa
hereditary breast ovarian cancer syndromeFlcn , Raf1 , Stk11
hereditary lymphedemaVegfc
hereditary lymphedema IDVegfc
hereditary multiple exostosesDeptor
Hereditary Neoplastic SyndromesAkt1 , Flcn , Fnip1 , Hras , Pik3ca , Stk11 , Tsc1 , Tsc2
hereditary spastic paraplegia 47Nras
hereditary spastic paraplegia 54Eif4ebp1
hereditary spastic paraplegia 63Lamtor5
heroin dependenceAkt1
Herpes Simplex Encephalitis 3Akt1
high grade gliomaAkt2 , Braf , Depdc5 , Hras , Igf1 , Map2k1 , Mapk3 , Mtor , Pik3ca , Pik3r3 , Prkca , Raf1 , Slc7a5 , Tsc1 , Vegfb
High MyopiaPrkaa2
Hirschsprung Disease 1Tsc2
Hirschsprung's diseaseIkbkb , Tsc2 , Ywhae
HirsutismRps6ka3
Hodgkin's lymphomaMapk1
Hot FlashesHif1a
human immunodeficiency virus infectious diseaseEif4a1 , Eif4ebp1 , Yy1
Huntington's diseaseCycs , Igf1 , Ppargc1a , Prkaa1
Hydrops FetalisHras
HyperalgesiaHif1a , Igf1 , Mapk1 , Mapk3 , Mtor , Raf1
HypercholesterolemiaSrebf1 , Vegfa
hyperglycemiaIns1 , Ins2 , Ppargc1a
hyperinsulinismIns2 , Irs1 , Rps6kb1
HyperkalemiaIns2
HyperoxiaBnip3 , Igf1
HyperphagiaIgf1
HyperplasiaAkt1 , Hif1a , Ikbkb , Pik3ca , Vegfa
HyperproinsulinemiaIns1 , Ins2
HypertelorismPik3ca , Rps6ka3
hypertensionAkt1 , Akt2 , Ccne1 , Hif1a , Igf1 , Ikbkb , Ins2 , Mtor , Pgf , Pik3r1 , Prkca , Rhoa , Rps6kb1 , Sgk1 , Stk11 , Vegfa , Ywhaz
hyperthyroidismCab39 , Ppargc1a , Stk11
HypertriglyceridemiaAkt1 , Ins2 , Mtor , Ppargc1a , Srebf1
hypertrophic cardiomyopathyBraf , Igf1 , Ins2 , Map2k2 , Raf1 , Yy1
hypertrophic cardiomyopathy 1Raf1
hypertrophic cardiomyopathy 4Braf
HypertrophyMapk1 , Mapk3
hyperuricemiaIns2
hypoglycemiaAkt2 , Ins1 , Ins2 , Pik3r1
hypogonadotropic hypogonadism 2 with or without anosmiaEif4ebp1
HypoinsulinemiaIns1 , Ins2
hypoinsulinemic hypoglycemia with hemihypertrophyAkt2
hypokalemiaIns2
Hypophosphatemic RicketsHras
HypopigmentationRhoa
HypoproteinemiaRps6kb1
HypotensionIns2 , Map2k2
hypothyroidismIgf1
HypoxiaPgf , Ppargc1a
Ichthyosis Follicularis, Atrichia, and Photophobia Syndrome 2Srebf1
ichthyosis follicularis-alopecia-photophobia syndrome 1Srebf1
idiopathic generalized epilepsyMlst8 , Pdpk1 , Telo2 , Tsc2 , Wdr24
idiopathic interstitial pneumoniaMtor
idiopathic pulmonary fibrosisAkt1 , Hif1a
Immunoblastic LymphadenopathyRhoa
immunodeficiency 14Mtor , Pik3cd
IMMUNODEFICIENCY 15Ikbkb
immunodeficiency 15AIkbkb
immunodeficiency 15BIkbkb
immunodeficiency 36Pik3r1
immunodeficiency 39Hras , Ins1 , Ins2
immunodeficiency 42Lamtor2
Immunodeficiency 93Fnip1
Immunodeficiency due to Defect in MAPBP-Interacting ProteinLamtor2
impotenceAkt1 , Vegfa
in situ carcinomaAkt1 , Sfn
Infantile Capillary HemangiomaVegfa
infantile Refsum diseaseVegfa
InfarctionHif1a
InflammationAkt1 , Eif4ebp1 , Ikbkb , Mtor , Pgf , Tsc2 , Vegfa
inflammatory bowel diseaseIkbkb , Vegfa
Insulin ResistanceAkt2 , Ikbkb , Ins1 , Ins2 , Irs1 , Lpin1 , Mapk3 , Pik3r1 , Ppargc1a , Prkaa1 , Prkaa2 , Srebf1 , Stk11 , Tsc1
Insulin-Like Growth Factor I DeficiencyIgf1
insulinomaIns2
intellectual disabilityAtg13 , Braf , Cab39l , Clip1 , Depdc5 , Hras , Igf1 , Lamtor1 , Mapk1 , Mtor , Nprl3 , Pgf , Pik3r2 , Poldip3 , Prr5 , Prr5l , Rps6ka3 , Rps6kb2 , Tsc1 , Tsc2 , Tti1 , Vegfb , Ywhag , Yy1
intermediate coronary syndromeAkt1
interstitial cystitisCdk2 , Hif1a , Mtor , Vegfa
Intervertebral Disc DiseaseHif1a
Intervertebral Disc DisplacementAkt1 , Hif1a , Igf1
Intestinal NeoplasmsPrkca
Intimal HyperplasiaCdk2 , Mapk1
intracranial aneurysmVegfa
intrahepatic cholangiocarcinomaBraf
invasive ductal carcinomaAkt1 , Hif1a , Pml , Vegfc
Invasive Pulmonary AspergillosisVegfa
inverted papillomaVegfa
ischemiaAkt2 , Cycs , Prkca , Raf1
ischemic colitisVegfa
Joint InstabilityTsc2
Joubert syndrome 1Flcn , Rps6kb1 , Srebf1
Joubert syndrome 22Cab39 , Eif4e2
juvenile myelomonocytic leukemiaNras
juvenile polyposis syndromeStk11
juvenile rheumatoid arthritisMapk1
Kawasaki diseaseVegfa
KBG syndromeSlc7a5
Kearns-Sayre syndromePpargc1a
KeloidSfn
keratoacanthomaPik3ca
keratoconusTsc1
KetosisIns1
kidney angiomyolipomaMtor
kidney cancerPpargc1a
kidney diseaseIgf1 , Ins2 , Mapk1 , Srebf1
kidney failureHif1a , Ins2 , Ppargc1a , Tsc1
Kidney NeoplasmsAkt1 , Braf , Eif4ebp1 , Mapk1 , Mapk3 , Raf1 , Tsc1 , Tsc2
Kidney Reperfusion InjuryBnip3 , Hif1a , Ikbkb , Ppargc1a
Klippel-Trenaunay syndromePik3ca
Knee OsteoarthritisIgf1
Kuhnt-Junius degenerationIgf1 , Vegfa
Langerhans-cell histiocytosisBraf
large cell carcinomaPrkca
large cell neuroendocrine carcinomaSlc7a5
large congenital melanocytic nevusHras , Nras
Laron syndromeIgf1
larynx cancerVegfa
learning disabilityIgf1 , Vegfa , Ywhag
Leber congenital amaurosisHras
Left Ventricular HypertrophyMapk1 , Mtor , Ppargc1a , Prkca , Rac1 , Rhoa , Rps6kb1 , Stk11
left ventricular noncompactionYwhae
Leigh diseaseTsc1
leiomyomaTsc2
lethal congenital glycogen storage disease of heartRheb
leukemiaDdit4 , Nras
leukocyte adhesion deficiency 3Vegfb
LeukocytosisNras
LeukoencephalopathiesFnip2 , Rhoa
Lewy body dementiaIns2 , Ppargc1a
Li-Fraumeni syndromeEif4a1
limb ischemiaHif1a , Vegfa
limited sclerodermaPgf
linear nevus sebaceous syndromeHras , Nras
lipid storage diseaseSrebf1
lipodystrophyLpin1
listeriosisPik3cd
liver cancerCcne1 , Hras , Ikbkb , Pik3ca
liver carcinomaHras , Nras
liver cirrhosisHif1a , Hras , Pgf , Vegfa , Vegfc
liver diseaseIns2 , Rac1
Liver FailureRps6 , Vegfa
Liver MetastasisBraf , Nras , Rictor , Slc7a5 , Vegfa
Liver NeoplasmsBraf , Flcn , Hras , Raf1
Liver Reperfusion InjuryAtg13 , Vegfa
long QT syndromeRheb
LONG-OLSEN-DISTELMAIER SYNDROMERragc
lung adenocarcinomaAkt1 , Braf , Eef2 , Eef2k , Hras , Map2k1 , Nras , Pik3ca , Pik3r1 , Rac1 , Raf1 , Rhoa , Sfn , Slc7a5 , Stk11
lung cancerBraf , Pik3ca , Pml , Rac1 , Rictor
lung carcinomaBraf , Pik3ca
lung diseaseHif1a , Igf1 , Vegfa
Lung InjuryMtor
lung metastasisRictor , Rptor
Lung NeoplasmsAkt1 , Braf , Eef2 , Hras , Mapk1 , Mapk3 , Mtor , Pdcd4 , Pik3ca , Raf1 , Slc7a5 , Stk11 , Tsc1 , Tsc2
lung non-small cell carcinomaAkt1 , Akt2 , Akt3 , Braf , Ccne1 , Cycs , Eef2 , Eif4ebp1 , Hif1a , Hras , Map2k1 , Map2k2 , Mtor , Nras , Pdpk1 , Pik3ca , Prkaa1 , Pxn , Raf1 , Rheb , Slc7a5 , Stk11 , Vegfa
lung oat cell carcinomaAkt1 , Pik3ca
lung pleomorphic carcinomaSlc7a5
lung small cell carcinomaAkt1 , Eef2 , Mtor , Pik3ca , Pik3r1 , Rictor
lung squamous cell carcinomaAkt1 , Braf , Cycs , Eef2 , Hras , Map2k1 , Pik3ca , Slc7a5 , Stk11
lupus nephritisMtor
LymphangiectasisRaf1
lymphangioleiomyomatosisRictor , Tsc1 , Tsc2 , Vegfd
lymphangiomaBraf , Pik3ca
Lymphatic MetastasisBraf , Cab39 , Ccne1 , Cycs , Mtor , Pdpk1 , Pik3ca , Pik3cb , Rhoa , Rictor , Sfn , Slc7a5 , Stk11 , Tsc2 , Vegfa , Vegfc , Vegfd
lymphedemaPgf
lymphomaNras
MacrocephalyAkt3 , Mtor , Pik3ca , Tbc1d7
Macrocephaly Mesodermal Hamartoma SpectrumAkt1
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveTbc1d7
macular corneal dystrophyWdr59
macular degenerationPpargc1a , Vegfa
macular retinal edemaHif1a , Vegfa
Maffucci syndromeHif1a
major depressive disorderEif4b
malignant astrocytomaAkt1 , Akt2 , Akt3 , Braf , Hif1a , Hras , Slc7a5
malignant fibrous histiocytomaPpargc1a
malignant mesotheliomaRaf1 , Ulk2
malignant pleural mesotheliomaSlc7a5
MalocclusionIgf1
Mandibular NeoplasmsBraf
Manganese PoisoningBnip3
mantle cell lymphomaEif4e , Eif4ebp1 , Mtor , Pik3cd
maple syrup urine diseaseAkt2
Marfanoid Mental Retardation Syndrome, AutosomalStk11
maturity-onset diabetes of the youngIns1 , Ins2
maturity-onset diabetes of the young type 1Akt2 , Ins1 , Ins2 , Irs1
maturity-onset diabetes of the young type 10Ins1 , Ins2
Meckel Syndrome 9Ulk2
medulloblastomaCcne1 , Nras , Pik3ca , Strada , Tsc2
megacolonAkt3
Megalencephaly - Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r1 , Pik3r2
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1Pik3r2
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2Akt3
MegalodactylyPik3ca
melanomaAkt1 , Braf , Cdk2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mtor , Nras , Pik3ca , Pik3r1 , Ppargc1a , Rac1 , Raf1 , Stk11 , Vegfa , Vegfc
melorheostosisMap2k1
membranoproliferative glomerulonephritisCdk2
membranous glomerulonephritisRhoa
Memory DisordersAkt1 , Hif1a , Igf1 , Ins2 , Mapk1 , Mapk3 , Vegfa
Meningeal NeoplasmsAkt1
meningiomaAkt1
MesotheliomaMtor
Metabolic Bone DiseasesIgf1
metabolic dysfunction and alcohol associated liver diseaseAkt1
metabolic dysfunction-associated steatohepatitisAkt1 , Srebf1 , Ulk1
metabolic dysfunction-associated steatotic liver diseaseAkt1 , Igf1 , Ins2 , Irs1 , Ppargc1a , Prkca , Srebf1
Metabolic SyndromeIns2 , Irs1 , Map2k2 , Ppargc1a , Prkaa2 , Srebf1 , Vegfa
methylmalonic acidemiaCycs
MHC class II deficiencyLamtor2
microcephalyIgf1 , Telo2 , Ywhag
Micronuclei, Chromosome-DefectiveHif1a , Ins2
Microsatellite InstabilityBraf
middle cerebral artery infarctionBnip3 , Hif1a , Igf1 , Ikbkb , Mapk1 , Mapk3 , Mtor , Pld1 , Vegfa
migraineMap2k2
Miller-Dieker lissencephaly syndromeYwhae
mitral valve prolapseMap2k2
morbid obesityHif1a , Lpin1
morphine dependenceMapk1 , Mapk3
mouth diseaseDdit4
Mouth NeoplasmsHras , Nras , Pik3ca , Sfn , Tsc1 , Tsc2
movement diseaseIgf1
MPTP PoisoningIns2
mucinous cystadenocarcinomaSgk1
mucositisUlk1
multicentric Castleman diseaseMap2k2
multiple congenital anomalies-hypotonia-seizures syndrome 2Vegfd
multiple endocrine neoplasia type 1Stk11 , Vegfb
multiple myelomaBnip3 , Braf , Hras , Nras , Pik3ca , Pik3r2 , Pml , Sgk1 , Vegfa , Yy1
Multiple Organ FailureMapk1
multiple sclerosisRhoa
Muscle HypotoniaYwhag
Muscle SpasticityYwhag
muscular atrophyAkt1 , Igf1 , Ikbkb , Mtor , Rps6kb1
muscular diseaseIns2
Muscular Dystrophy, AnimalMtor , Ppargc1a
muscular dystrophy-dystroglycanopathy type B6Depdc5 , Ywhah
mycosis fungoidesHif1a
myelodysplastic syndromeHras , Nras
myeloid leukemiaVegfa
myeloid leukemia associated with Down SyndromeNras
myeloid neoplasmNras
myocardial infarctionAkt1 , Bnip3 , Hif1a , Igf1 , Mapk1 , Mtor , Pgf , Ppargc1a , Rps6kb1 , Vegfa , Vegfb
Myocardial IschemiaEif4e , Eif4ebp1 , Hif1a , Igf1 , Pgf , Vegfa
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bnip3 , Hif1a , Mapk1 , Mapk3 , Pld2 , Ppargc1a , Prkaa2 , Rhoa , Vegfa
myoepitheliomaBraf
myopiaIgf1
Nance-Horan syndromeRps6ka3
Nasal PolypsIgf1 , Vegfa
Nasopharyngeal NeoplasmsHras , Nras , Pik3ca
nasopharynx carcinomaRac1 , Vegfa
NATURAL KILLER CELL ENTEROPATHYPik3cb
NecrosisIns1
Nematode InfectionsPik3r1
NeointimaAkt1 , Igf1 , Yy1
neonatal diabetesIns1 , Ins2
Neonatal HyperbilirubinemiaIkbkb
Neonatal Hypoglycemia, Simulating Foetopathia DiabeticaAkt2
Neoplasm InvasivenessEef2 , Eif4e , Hif1a , Hras , Igf1 , Ins2 , Mapk1 , Mapk3 , Pdcd4 , Rhoa , Rps6ka3
Neoplasm MetastasisAkt2 , Braf , Cab39 , Ccne1 , Eef2 , Igf1 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3r3 , Pml , Pxn , Rac1 , Rhoa , Rps6ka3 , Slc7a5 , Vegfa , Ywhae
Neoplasm MicrometastasisCycs
Neoplasm Recurrence, LocalVegfa , Ywhaz
Neoplasms, Second PrimaryPml
Neoplastic Cell TransformationHif1a , Hras , Irs1 , Pdcd4 , Pxn , Rac1 , Vegfa
Neoplastic ProcessesHras
neovascular glaucomaVegfa
Neovascularization, PathologicVegfa
nephritisMtor
nephroblastomaBraf , Hif1a , Vegfc
nephrogenic diabetes insipidusPrkca
nephrotic syndromePpargc1a
Nerve DegenerationDdit4 , Igf1 , Mapk1 , Mapk3 , Tsc2 , Vegfa
Nervous System MalformationsTsc2
neural tube defectIns2
neuroblastomaHras , Nras , Pik3ca , Tsc1 , Tsc2
Neurocutaneous MelanosisNras
Neurocutaneous SyndromesRhoa
neurodevelopmental disorder with dysmorphic facies and distal limb anomaliesRac1
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY AND MOVEMENT ABNORMALITIESTti1
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIESDepdc5 , Pik3ca
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, HYPOTONIA, NYSTAGMUS, AND SEIZURESYwhaq
Neurodevelopmental DisordersAkt3 , Fnip1 , Igf1 , Mapk3 , Mtor , Nras , Pik3cd , Pik3r1 , Prkaa1 , Rictor , Rps6ka3 , Tsc2 , Vegfc , Vegfd , Wdr59 , Ywhaz , Yy1
NEURODEVELOPMENTAL, JAW, EYE, AND DIGITAL SYNDROMEFbxw11
neuroendocrine tumorBraf
neurofibromatosis 1Vegfa
neurofibromatosis-Noonan syndromeMap2k2
neurofibrosarcomaNras , Vegfa
neuronal ceroid lipofuscinosisHras , Ins1 , Ins2 , Map2k1
neuronal ceroid lipofuscinosis 1Ppargc1a , Rps6kb1
neuronal ceroid lipofuscinosis 6AMapk1 , Mapk3
NevusBraf
newborn respiratory distress syndromeBraf , Nprl2 , Vegfa
nicotine dependenceRptor
non-Hodgkin lymphomaBraf , Map2k1 , Nras , Pik3ca , Rhoa
non-syndromic X-linked intellectual disability 19Rps6ka3
nonpapillary renal cell carcinomaFlcn
Nonseminomatous Germ Cell TumorBraf
Noonan Like SyndromeYwhaz
Noonan syndromeBraf , Hras , Igf1 , Map2k1 , Map2k2 , Nras , Raf1
Noonan syndrome 1Braf , Hras , Map2k1 , Map2k2 , Nras , Raf1
Noonan syndrome 13Mapk1
Noonan syndrome 3Hras , Raf1
Noonan syndrome 5Raf1
Noonan syndrome 6Nras
Noonan syndrome 7Braf
Noonan syndrome 8Lamtor2 , Pik3ca
Noonan syndrome with multiple lentiginesBraf , Map2k2 , Raf1
Noonan syndrome with multiple lentigines 2Raf1
Noonan syndrome with multiple lentigines 3Braf
obesityAkt1 , Akt2 , Bnip3 , Cycs , Hif1a , Ikbkb , Ins2 , Irs1 , Mapk1 , Mapk3 , Mtor , Pgf , Pik3r1 , Ppargc1a , Rhoa , Rps6kb1 , Srebf1 , Stk11 , Tsc1
obsessive-compulsive disorderHras
occupational asthmaPrkca
olfactory neuroblastomaHif1a
Ollier diseaseHif1a
opiate dependenceAkt1 , Vegfa
Optic Nerve InjuriesCdk2 , Rhoa
oral squamous cell carcinomaSlc7a5 , Vegfa
Orthomyxoviridae InfectionsPld2
osteoarthritisEef2 , Hif1a , Igf1 , Ins2 , Mtor , Pik3r1 , Ywhaq
Osteoarthritis, ExperimentalMapk3 , Ulk1
osteochondrodysplasiaVegfa
OsteophytesIgf1
osteoporosisIgf1 , Irs1
Osteoporotic FracturesIgf1
osteosarcomaAkt1 , Vegfa
otitis mediaVegfa
Otitis Media with EffusionVegfa
ovarian cancerAkt1 , Flcn , Hif1a , Hras , Pik3ca , Prkca , Sfn , Stk11 , Tsc1 , Tsc2 , Vegfc
ovarian carcinomaAkt2 , Ccne1 , Map2k1 , Prkca , Raf1 , Rhoa , Stk11 , Vegfd
ovarian hyperstimulation syndromeVegfa
Ovarian NeoplasmsAkt1 , Akt2 , Braf , Ccne1 , Cdk2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Pik3ca , Pik3r1 , Vegfa
ovarian serous cystadenocarcinomaBraf , Hras , Nras , Pik3ca
Oxygen-Induced RetinopathyHif1a , Igf1 , Vegfa
Paget's disease of bonePml
PainAkt1 , Map2k2
pancreatic acinar cell adenocarcinomaBraf
pancreatic adenocarcinomaAkt3 , Hras , Map2k1 , Map2k2 , Mapk1 , Pik3ca , Rac1 , Raf1 , Vegfc
pancreatic cancerAkt1 , Akt2 , Braf , Cab39 , Cycs , Hif1a , Igf1 , Ins2 , Mtor , Stk11 , Tsc2 , Vegfb
pancreatic carcinomaMtor , Raf1 , Stk11 , Tsc1
pancreatic ductal adenocarcinomaIkbkb , Pgf , Pik3r2 , Pld1 , Rac1 , Vegfd
pancreatic ductal carcinomaIgf1 , Ins2 , Mapk3 , Stk11 , Tsc2 , Vegfa
pancreatic endocrine carcinomaPgf
pancreatic intraductal papillary-mucinous neoplasmAkt1 , Vegfd
Pancreatic Intraepithelial NeoplasiaIkbkb
Pancreatic NeoplasmsStk11
pancreatitisIkbkb , Ins2 , Map2k1
panic disorderIns2
PAPA syndromePml , Ulk3
papillary carcinomaVegfc
papillary renal cell carcinomaBraf , Hras , Mtor , Pik3ca , Rheb
papillary thyroid carcinomaBraf
papillomaHras
ParalysisIns2
paraplegiaAkt1 , Eif4ebp1 , Wdr59
ParaproteinemiasBraf , Hras , Nras , Pik3ca
parathyroid adenomaHras
parathyroid carcinomaAkt3 , Lamtor2
ParesthesiaIns2
Parkinson's diseaseAkt1 , Ddit4 , Ins2 , Mapk1 , Mapk3 , Ppargc1a , Rrn3
ParkinsonismFkbp1a , Mtor , Ppargc1a
PEHO syndromeIgf1
Penetrating WoundsPgf
Penile NeoplasmsHras , Pik3ca
perinatal necrotizing enterocolitisBnip3
Periodontal AtrophyVegfa
peripheral nervous system diseaseIgf1
peripheral T-cell lymphomaRhoa
Perlman syndromeCab39 , Eif4e2
permanent neonatal diabetes mellitusIns1 , Ins2
Permanent Neonatal Diabetes Mellitus 4Ins1 , Ins2
Peutz-Jeghers syndromeStk11
PHACE AssociationBraf
Phelan-McDermid syndromeIns2 , Prr5
phobic disorderHras
Phyllodes TumorHif1a
Pierson syndromeRhoa
Pigmented NevusHras , Nras
pilocytic astrocytomaFlcn
Pituitary NeoplasmsIgf1 , Prkca
Pituitary Stalk Interruption SyndromeRaf1
placental insufficiencyPpargc1a
Plaque, AtheroscleroticIgf1 , Ppargc1a
plasma cell neoplasmBraf , Hras , Nras , Pik3ca
pleomorphic xanthoastrocytomaBraf , Castor2 , Cycs , Lamtor4 , Tsc1 , Ywhag
pleuropulmonary blastomaYy1
Pneumococcal PneumoniaMapk1 , Mapk3
pneumoniaIkbkb
pneumothoraxFlcn
polyarteritis nodosaVegfa
polycystic kidney diseaseHif1a , Mtor , Pik3ca , Tsc2
polycystic ovary syndromeAkt2 , Igf1 , Ins2 , Vegfa
polyhydramnios, megalencephaly, and symptomatic epilepsyStrada
polymicrogyriaAkt3
Polypoidal Choroidal VasculopathyVegfa
PolyuriaPrkca
portal hypertensionMapk1 , Mtor , Pik3r1 , Vegfa
Postmenopausal OsteoporosisHif1a , Igf1
Postoperative Cognitive DysfunctionMapk1 , Mapk3
Potocki-Lupski syndromeFlcn , Srebf1 , Ulk2
pre-eclampsiaHif1a , Pgf , Pml , Vegfa
pre-malignant neoplasmAkt1 , Eif4ebp1 , Hras , Irs1 , Prkaa1 , Tsc2 , Vegfa
Precocious PubertyIgf1
prediabetes syndromePpargc1a
Pregnancy in DiabeticsVegfa
Premature BirthBraf , Pgf
primary biliary cholangitisHif1a , Ppargc1a , Rps6kb1 , Vegfa
primary ciliary dyskinesiaNprl2
primary ciliary dyskinesia 33Slc7a5
primary coenzyme Q10 deficiency 7Tsc1 , Tsc2
primary cutaneous T-cell non-Hodgkin lymphomaBraf , Rhoa
primary immunodeficiency diseasePik3cd , Pik3r1
primary ovarian insufficiencyRictor
primary sclerosing cholangitisVegfa
primary spontaneous pneumothoraxFlcn
Primitive Neuroectodermal TumorsTsc1
progeriaIgf1
progressive myoclonus epilepsyTsc1
proliferative diabetic retinopathyVegfa
prostate adenocarcinomaAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Map2k1 , Mapk1 , Pdpk1 , Pik3ca , Pik3cb , Raf1
prostate cancerAkt1 , Akt2 , Akt3 , Atg13 , Cdk2 , Eef2 , Hif1a , Ikbkb , Ins2 , Mtor , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Raf1 , Ulk2 , Vegfa
Prostate Cancer, Hereditary, 1Braf , Hras , Nras
prostate carcinomaAkt2 , Prkca
prostate carcinoma in situCcne1 , Igf1 , Stk11
Prostatic NeoplasmsAkt1 , Akt2 , Bnip3 , Braf , Ccne1 , Hif1a , Hras , Igf1 , Ins2 , Irs1 , Map2k1 , Map2k2 , Mapk3 , Mtor , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pml , Raf1 , Vegfa
proteinuriaHif1a , Rhoa , Vegfa
Proteus syndromeAkt1
pseudoxanthoma elasticumVegfa
psoriasisHif1a , Igf1 , Ikbkb , Vegfa
Psychomotor DisordersRps6ka3
PTEN hamartoma tumor syndromePik3ca
pterygiumVegfa , Vegfc
Pulmonary Arterial HypertensionPdcd4
pulmonary edemaVegfa
pulmonary emphysemaPgf , Ppargc1a
pulmonary fibrosisIgf1 , Mtor
pulmonary hypertensionHif1a , Mapk1 , Mapk3 , Mtor , Pgf , Rhoa , Vegfa , Vegfb
pulmonary tuberculosisAkt1
pulmonary valve stenosisBraf , Hras
pycnodysostosisIgf1
pyelonephritisPgf
Pyogenic GranulomaNras
Pyruvate Dehydrogenase E1 Alpha DeficiencyRps6ka3
Radiation InjuriesHif1a
Rafiq syndromeTsc1
RASopathyBraf , Eef2 , Hras , Map2k1 , Map2k2 , Nras , Pdcd4 , Raf1
rectal benign neoplasmNras , Pik3ca , Pik3cb
rectum adenocarcinomaEef2 , Slc7a5
RecurrenceCcne1 , Eef2 , Hras , Vegfc
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsRps6kb2
renal carcinomaMtor
renal cell carcinomaAkt1 , Akt3 , Ccne1 , Cdk2 , Eef2 , Flcn , Hif1a , Map2k1 , Mapk1 , Mtor , Nras , Pgf , Pik3ca , Pik3r1 , Pld2 , Rheb , Tsc1 , Tsc2 , Vegfa , Vegfc
Renal Cell Carcinoma 1Mtor , Nras , Pik3ca , Rheb
renal fibrosisMapk1 , Ppargc1a
renal hypomagnesemia 7, with or without dilated cardiomyopathyRragd
renal oncocytomaFlcn
renal Wilms' tumorVegfa
Reperfusion InjuryAkt1 , Akt1s1 , Ccne1 , Eef2 , Hif1a , Igf1 , Pik3r1 , Pld2 , Prkca , Vegfc , Vegfd
respiratory allergyVegfa
Retina Reperfusion InjuryVegfa
retinal detachmentBnip3
retinal diseaseVegfa
retinal ischemiaHif1a , Vegfa
Retinal NeovascularizationHif1a , Mtor , Vegfa , Vegfb
retinal telangiectasiaVegfa
retinal vein occlusionVegfa , Vegfb
retinitis pigmentosaVegfa
retinitis pigmentosa 59Rps6ka1 , Sfn
retinopathy of prematurityIgf1 , Vegfa
RhabdomyolysisIns2
rhabdomyosarcomaHras , Vegfa
rheumatic heart diseaseIgf1
rheumatoid arthritisDdit4 , Hif1a , Pgf , Pik3r1 , Vegfa
rhinitisVegfa
RhinosinusitisIgf1
Right Ventricular HypertrophyAkt1 , Igf1 , Mtor , Ppargc1a , Prkca , Slc7a5 , Vegfa
Roifman-Chitayat SyndromePik3cd
rosette-forming glioneuronal tumorPik3ca
Rotavirus InfectionsPml
Salivary Gland NeoplasmsHras
sarcomaPik3ca
SarcopeniaIgf1 , Ppargc1a
schizophreniaAkt1 , Eef2k , Fnip1 , Lpin1 , Mapk3 , Mtor , Nprl2 , Pik3cb , Pik3cd , Pml , Ppargc1a , Rb1cc1 , Rrn3 , Ulk3 , Ywhah , Ywhaz
sciatic neuropathyMtor , Ppargc1a
sclerosing cholangitisHif1a
Seasonal Allergic RhinitisVegfa
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Nras
seborrheic keratosisPik3ca
Segawa Syndrome, Autosomal RecessiveIns1 , Ins2
seminomaHras , Vegfa
Sengers syndromeBraf
Senior-Loken syndromeAkt3
Senior-Loken Syndrome 7Akt3
SepsisEif4e , Irs1 , Mapk1 , Mapk3 , Mtor , Pgf , Ppargc1a , Rac1
septic myocarditisPrkaa2
Septic PeritonitisPik3r1
serous cystadenocarcinomaSgk1
severe acute respiratory syndromeIgf1 , Mapk1 , Mapk3
severe combined immunodeficiencyIkbkb
severe congenital neutropenia 3Lamtor2
severe congenital neutropenia 5Lamtor2
Sezary's diseaseBraf , Mapk1 , Rps6ka1
ShockMapk1 , Mapk3
short chain acyl-CoA dehydrogenase deficiencyClip1 , Pxn
SHORT syndromePik3r1
short-rib thoracic dysplasia 9 with or without polydactylyMlst8 , Pdpk1 , Telo2 , Tsc2 , Wdr24
sickle cell anemiaPgf
Silver-Russell Syndrome 1Ins1
Silver-Russell Syndrome 3Ins1
skin benign neoplasmHras
skin cancerPml
skin melanomaAkt1 , Braf , Hif1a , Hras , Map2k1 , Map2k2 , Mtor , Nras , Pdcd4 , Pik3ca , Pik3r1 , Rac1 , Raf1 , Stk11
Skin NeoplasmsAkt1 , Hif1a , Hras , Igf1 , Vegfa
Skull FracturesIgf1
Sleep DeprivationEef2
Sleep Initiation and Maintenance DisordersPpargc1a
small cell carcinomaMtor
small intestine adenocarcinomaMap2k1 , Map2k2
Small-For-Size SyndromeVegfa
Smith-Kingsmore SyndromeMtor , Pik3r1 , Pik3r2
Smith-Magenis syndromeMap2k2 , Srebf1
spastic ataxiaPik3r5
spermatocytomaHras
spermatogenic failure 57Map2k1
Spinal Cord InjuriesAkt1 , Akt1s1 , Bnip3 , Ccne1 , Hif1a , Mtor , Ppargc1a , Rhoa , Slc7a5 , Ulk1 , Vegfa
spinal diseaseTsc1
spinocerebellar ataxia type 19/22Eef2
spinocerebellar ataxia type 26Eef2
Splenic NeoplasmsHras
SplenomegalyNras
spondylocostal dysostosis 5Mapk3
Spontaneous AbortionsIgf1 , Pgf
Sporadic Creutzfeldt-Jakob DiseaseYwhag
Sporadic Papillary Renal Cell CarcinomaBraf , Hras , Mtor , Pik3ca , Rheb
squamous cell carcinomaAkt1 , Hras , Mapk1 , Mapk3 , Pik3ca , Sfn , Stk11 , Tsc1 , Tsc2 , Vegfa
Staphylococcal PneumoniaAkt1
status epilepticusMtor , Pgf , Vegfa
steatotic liver diseaseAkt1 , Cycs , Ins2 , Ppargc1a , Prkaa1 , Srebf1
Stevens-Johnson syndromePml
stomach cancerEef2 , Pik3ca , Rac1 , Rictor , Slc7a5 , Stk11
Stomach NeoplasmsBnip3 , Hras , Mapk1 , Mapk3 , Nras , Pik3ca , Prkaa1 , Rhoa , Rps6
Streptococcus pneumoniaPik3cd
StrokeAkt1 , Igf1 , Pgf , Pik3ca , Prkaa2 , Vegfa
Sturge-Weber syndromeMap2k1
Subarachnoid HemorrhageBnip3 , Hif1a , Pik3cb
substance-induced psychosisAkt1
Sudden Hearing LossIgf1
sudden infant death syndromeDepdc5 , Vegfa
syndromic X-linked intellectual disability Lubs typeRps6ka3 , Rps6ka6 , RragB , Vegfd
systemic lupus erythematosusPgf , Ywhab
systemic primary carnitine deficiency diseaseFnip1
systemic sclerodermaVegfa
T-cell acute lymphoblastic leukemiaMtor
T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac MalformationsYwhab
T-cell non-Hodgkin lymphomaAkt1 , Hras , Rhoa
TachycardiaIns2
Takotsubo CardiomyopathyPpargc1a
temporal lobe epilepsyMtor , Pgf , Vegfa
Temporomandibular Joint DisordersHif1a , Mtor
Temporomandibular Joint OsteoarthritisRps6
testicular cancerStk11
testicular germ cell cancerStk11
Testicular Germ Cell TumorStk11
Testis Reperfusion InjuryHif1a , Mapk1 , Mapk3
tethered spinal cord syndromeBraf
ThinnessIgf1
thrombocytopeniaCycs
Thrombocytopenia 4Cycs
thrombosisPik3cb
Thrombotic MicroangiopathiesVegfa
thymomaHras
thyroid cancerMapk1
Thyroid NeoplasmsAkt1 , Akt2 , Braf , Hif1a , Hras , Mapk1 , Nras , Pik3ca
Tibial FracturesPgf
Tobacco Use DisorderRptor
tongue cancerRictor
Tongue NeoplasmsHras , Igf1 , Vegfa , Vegfc
tongue squamous cell carcinomaSlc7a5
tooth diseaseRhoa
torsion dystonia 6Ikbkb
toxic encephalopathyMtor
toxic shock syndromePik3cd
transient cerebral ischemiaBnip3 , Cab39 , Cycs , Hif1a , Igf1 , Ikbkb , Mtor , Rps6 , Sgk1
transient neonatal diabetes mellitusIns1 , Ins2
transitional cell carcinomaAkt1 , Braf , Hras , Map2k1 , Mapk1 , Mtor , Nras , Pik3ca , Rheb , Sfn , Slc7a5
Transplant RejectionIkbkb
TrichilemmomaHras
trichorhinophalangeal syndrome type IDeptor
trigeminal neuralgiaMapk1 , Mapk3
Triple Negative Breast NeoplasmsCdk2
tuberous sclerosisEif4ebp1 , Tsc1 , Tsc2
tuberous sclerosis 1Tsc1 , Tsc2
tuberous sclerosis 2Mlst8 , Telo2 , Tsc2 , Wdr24
Turner syndromeIgf1
Tympanic Membrane PerforationVegfa
type 1 diabetes mellitusIgf1 , Ins1 , Ins2 , Ppargc1a , Yy1
type 1 diabetes mellitus 2Ins1 , Ins2
type 2 diabetes mellitusAkt1 , Akt2 , Braf , Hif1a , Igf1 , Ikbkb , Ins1 , Ins2 , Irs1 , Mapk1 , Mapk3 , Mtor , Pik3cb , Pik3r1 , Ppargc1a , Prkaa1 , Prkaa2 , Srebf1 , Vegfa
Type 2 Diabetes Mellitus 1Ins1 , Ins2
UlcerHif1a
ulcerative colitisVegfa
Urban Schosser Spohn SyndromeSrebf1
uremiaSgk1
ureteral obstructionAkt1 , Mapk1 , Mapk3 , Mtor
urethral obstructionMapk1
urinary bladder cancerAkt1 , Ccne1 , Hif1a , Hras , Igf1 , Mtor , Pik3ca , Prkca , Rhoa , Sfn , Tsc1 , Vegfa , Vegfc , Vegfd
Urinary Bladder NeoplasmHras , Tsc1
Urinary IncontinenceMapk1
Urologic NeoplasmsHif1a , Rhoa , Vegfa
uterine cancerBraf , Hras , Map2k1 , Mtor , Nras , Pik3ca , Pik3r1 , Rac1 , Rheb
uterine carcinosarcomaHras , Pik3ca , Pik3r1
Uterine Cervical NeoplasmsAkt1 , Ccne1 , Cdk2 , Hras , Mapk1 , Mtor , Pik3ca , Vegfa , Yy1
uterine fibroidIrs1 , Tsc2
uveal melanomaIgf1 , Vegfa
varicoceleHif1a
vascular dementiaEif4e , Igf1 , Mapk1 , Mtor , Rps6 , Tsc2
vascular diseaseIkbkb
Vascular MalformationsBraf , Hras , Map2k1 , Pik3ca , Pik3r1
velocardiofacial syndromeMapk1
Venous ThrombosisHif1a
Ventilator-Induced Lung InjuryAkt1
Ventricular Dysfunction, LeftIns1 , Ins2 , Pik3ca , Prkaa2 , Rac1
Ventricular Dysfunction, RightPpargc1a
Ventricular FibrillationIns2
Ventricular Outflow ObstructionIns2
Ventricular RemodelingAkt1 , Hif1a , Vegfa
ventricular septal defectBraf
Ventricular TachycardiaRaf1
very long chain acyl-CoA dehydrogenase deficiencyEif4a1
vestibular schwannomatosisVegfa
Viral MyocarditisSrebf1
visceral leishmaniasisPik3cd
visual epilepsyDepdc5 , Pld1 , Pld2 , Ywhab , Ywhaz
vitiligoPik3r1
vulva cancerAkt1
vulva squamous cell carcinomaSfn
Wallerian DegenerationPgf
Weight GainPik3ca
Weight LossIns1 , Ins2
Weissenbacher-Zweymuller syndromeMapk1
Werner syndromeHif1a
West syndromeTsc1 , Tsc2
withdrawal disorderMapk1 , Mapk3 , Rhoa
Wolff-Parkinson-White syndromeFnip1
Wounds and InjuriesIgf1 , Vegfa
X-linked agammaglobulinemiaPik3r1
YOU-HOOVER-FONG SYNDROMETelo2
Zellweger syndromeVegfa
Zinc DeficiencyIgf1
Pathway Annotations Associated with Genes in the mTOR signaling pathway
Pathway TermsGene Symbols
activin signaling pathwayFkbp1a
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Braf , Eif4ebp1 , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pml , Raf1 , Rps6kb1 , Rps6kb2
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayCab39 , Prkaa1 , Prkaa2 , Stk11 , Strada , Tsc1
adenosine signaling pathwayAkt1 , Braf , Hras , Ikbkb , Map2k2 , Mapk1 , Pdpk1 , Pik3ca , Rps6ka1
aldosterone signaling pathwayIgf1 , Ins1 , Ins2 , Irs1 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkca , Sfn , Sgk1
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered insulin signaling pathwayIns2
altered insulin-like growth factor signaling pathwayIgf1
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expressionVegfa
altered vascular endothelial growth factor signaling pathway involving the main playersVegfa
Alzheimer's disease pathwayCycs , Mapk1 , Mapk3
amiloride pharmacodynamics pathwaySlc7a5
amyotrophic lateral sclerosis pathwayCycs , Rac1
angiotensin II signaling pathwayPdpk1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Cycs , Ikbkb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Arf family mediated signaling pathwayPld2 , Rac1
autophagy pathwayAtg13 , Ins1 , Ins2 , Prkaa1 , Prkaa2 , Rb1cc1 , Ulk1 , Ulk2 , Ulk3
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1
bendroflumethiazide pharmacodynamics pathwaySlc7a5
bevacizumab pharmacodynamics pathwayVegfa
Bone morphogenetic proteins signaling pathwayMapk1
bumetanide pharmacodynamics pathwaySlc7a5
c-Jun N-terminal kinases MAPK signaling pathwayRac1
calcium signaling pathway via the calcium-sensing receptorRhoa
calcium/calcium-mediated signaling pathwayPrkca
cardiolipin metabolic pathwayCycs
cardiovascular system disease pathwayIgf1
cell cycle pathway, mitoticCcne1 , Cdk2 , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cycs , Igf1 , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
Chagas disease pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pxn , Rac1 , Raf1 , Rhoa
chlorothiazide pharmacodynamics pathwaySlc7a5
chlorthalidone pharmacodynamics pathwaySlc7a5
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Cycs , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rhoa
CRM1 export pathwayEif4e
cystinuria pathwaySlc7a5
cytokine mediated signaling pathwayVegfc , Vegfd
dilated cardiomyopathy pathwayIgf1
E-cadherin signaling pathwayAkt1 , Akt2 , Igf1 , Pik3ca , Pik3r1 , Rac1 , Rhoa
eicosanoid signaling pathwayAkt1 , Pik3r5 , Prkca , Rac1 , Rhoa
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
electron transport chain pathwayCycs
endocytosis pathwayHras , Pld1 , Pld2 , Pml , Rhoa
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
endothelin signaling pathwayAkt1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Prkca , Rac1 , Raf1 , Rhoa
Entamoebiasis pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca
ephrin - ephrin receptor bidirectional signaling axisHras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Pik3r5 , Pxn , Rac1 , Rhoa
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Eif4ebp1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Raf1 , Rps6kb1 , Rps6kb2
eplerenone pharmacodynamics pathwaySlc7a5
erythropoietin signaling pathwayHras , Pik3r1
etacrynic acid pharmacodynamics pathwaySlc7a5
ether lipid metabolic pathwayPld1 , Pld2
ether lipid metabolic pathwayPld1 , Pld2
FasL mediated signaling pathwayAkt1 , Ikbkb , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Rac1 , Raf1
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Pld2 , Prkca , Rac1 , Raf1 , Rps6kb1 , Rps6kb2
fibroblast growth factor signaling pathwayAkt1 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1 , Rps6ka1
forkhead class A signaling pathwayAkt1 , Ins2
furosemide pharmacodynamics pathwaySlc7a5
G1/S DNA damage checkpoint pathwayCcne1
G1/S transition pathwayCcne1 , Cdk2
gliclazide pharmacodynamics pathwayIns2
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Igf1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Prkca , Raf1
glucocorticoid signaling pathwaySgk1
glutamate signaling pathwayMapk1 , Mapk3 , Pld1 , Pld2 , Prkca
glyburide pharmacodynamics pathwayIns2
glycerophospholipid metabolic pathwayPld1 , Pld2
glypican signaling pathwayVegfa
gonadotropin-releasing hormone signaling pathwayHras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pld1 , Pld2 , Prkca , Raf1
granulocyte-macrophage colony-stimulating factor signaling pathwayHras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Ywhaz
Hartnup disease pathwaySlc7a5
Hedgehog signaling pathwayAkt1 , Fbxw11 , Map2k1 , Pik3ca , Pik3r1 , Sspo
hepatitis C pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
histone modification pathwayYwhaz
Huntington's disease pathwayCycs , Ppargc1a
hydrochlorothiazide pharmacodynamics pathwaySlc7a5
hydroflumethiazide pharmacodynamics pathwaySlc7a5
hypertrophic cardiomyopathy pathwayIgf1 , Prkaa1 , Prkaa2
hypoxia inducible factor pathwayAkt1 , Bnip3 , Hif1a , Vegfa
iminoglycinuria pathwaySlc7a5
influenza A pathwayAkt1 , Akt2 , Akt3 , Cycs , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pml , Prkca , Raf1
INO80 family mediated chromatin remodeling pathwayYy1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Ins2 , Rac1 , Sfn , Ywhab , Ywhae , Ywhag , Ywhah , Ywhaq , Ywhaz
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Eif4e , Eif4e2 , Eif4ebp1 , Hras , Ikbkb , Ins1 , Ins2 , Irs1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mtor , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ppargc1a , Prkaa1 , Prkaa2 , Prkca , Raf1 , Rheb , Rps6 , Rps6kb1 , Rps6kb2 , Rptor , Sgk1 , Srebf1 , Tsc1 , Tsc2
insulin-like growth factor signaling pathwayAkt1 , Hras , Igf1 , Irs1 , Pdpk1 , Pik3ca , Pik3r1 , Pxn , Raf1 , Rps6kb1 , Ywhae , Ywhaz
integrin mediated signaling pathwayPxn
interleukin-1 signaling pathwayIkbkb , Pik3ca , Pik3r1
interleukin-12 signaling pathwayMtor
interleukin-2 signaling pathwayCdk2 , Hras , Irs1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Rhoa
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayPik3ca , Pik3r1 , Ywhag , Ywhaz
interleukin-4 signaling pathwayAkt1 , Irs1 , Mtor , Pik3ca , Pik3r1 , Rps6kb1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Pik3ca , Pik3r1 , Rac1
intrinsic apoptotic pathwayBnip3 , Cycs
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Leishmaniasis pathwayMapk1 , Mapk3
leptin system pathwayIrs1
long term depressionBraf , Hras , Igf1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Raf1
long term potentiationBraf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6
lysinuric protein intolerance pathwaySlc7a5
maturity-onset diabetes of the young pathwayIns1 , Ins2
measles pathwayAkt1 , Akt2 , Akt3 , Ccne1 , Cdk2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
melanoma pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Igf1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
metolazone pharmacodynamics pathwaySlc7a5
mitochondrial autophagy pathwayBnip3 , Ulk1
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Prkca , Rac1 , Raf1 , Rps6ka1 , Rps6ka2 , Rps6ka3 , Rps6ka6 , Tsc2
mTOR signaling pathwayAkt1 , Akt1s1 , Akt2 , Akt3 , Atg13 , Bnip3 , Braf , Cab39 , Cab39l , Castor1 , Castor2 , Ccne1 , Cdk2 , Clip1 , Cycs , Ddit4 , Depdc5 , Deptor , Eef2 , Eef2k , Eif4a1 , Eif4b , Eif4e , Eif4e2 , Eif4ebp1 , Fbxw11 , Fkbp1a , Flcn , Fnip1 , Fnip2 , Hif1a , Hras , Igf1 , Ikbkb , Ins1 , Ins2 , Irs1 , Lamtor1 , Lamtor2 , Lamtor3 , Lamtor4 , Lamtor5 , Lpin1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mapkap1 , Mios , Mlst8 , Mtor , Nprl2 , Nprl3 , Nras , Pdcd4 , Pdpk1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Pld2 , Pml , Poldip3 , Ppargc1a , Prkaa1 , Prkaa2 , Prkca , Prr5 , Prr5l , Pxn , Rac1 , Raf1 , Rb1cc1 , Rheb , Rhoa , Rictor , Rps6 , Rps6ka1 , Rps6ka2 ,