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ALZHEIMER'S DISEASE PATHWAY (PW:0000015)

View Ontology Report

Description

Alzheimer's Disease (AD) is a progressive neurodegenerative disease, largely sporadic and of late-onset (LOAD), with a small percentage of cases being familial, early-onset (EOAD). It is characterized by the progressive loss of memory and mental capabilities, eventually resulting in total functional loss. AD is the most prevalent cause of dementia, it affects millions of people and the number is estimated to increase; the billions of dollars in healthcare costs are estimated to reach the trillio

Pathway Diagram:

Elsevier Inc. potential AD miRNA neurofibrillary tangles microglia neuroinflam mation hyperphosphorylated Tau AD susceptibility genes Abeta toxic Abeta ---| mitochondria dynamics pathway Abeta interacting partners ---- toxic Abeta senile amyloid plaques gamma-secretase ---> toxic Abeta App Apoe ---> lipoprotein metabolism tau kinases ---> hyperphosphorylated Tau Bace1 gamma-secretase ---> App Bace1 ---> App Apoe ---> cholesterol transport Bace1 ---> Abeta gamma-secretase ---> Abeta Abeta degrading enzymes ---> toxic Abeta Abeta degrading enzymes ---> Abeta Mapt tau phosphatases ---> Mapt tau kinases ---> Mapt Apoe astrocyte toxic Abeta ---| respiratory complex IV microtubule cytoskeleton assembly Mapt ---> microtubule cytoskeleton assembly oxidative stress --+> tau kinases oxidative stress ---| tau phosphatases proteostatic stress oxidative stress potential AD miRNA ---> Alzheimer's Disease (AD) cholesterol transport lipoprotein metabolism ApoE4 ---> impaired cholesterol/lipid, impaired vesicle endocytosis AD susceptibility genes ---> synaptic dysfunction, synapse loss, cognitive decline AD susceptibility genes ---> impaired cholesterol/lipid, impaired vesicle endocytosis cerebral hypoperfusion ---> synaptic dysfunction, synapse loss, cognitive decline glucose hypometabolism ---> synaptic dysfunction, synapse loss, cognitive decline hyperphosphorylated Tau ---| mitochondria dynamics pathway hyperphosphorylated Tau ---| respiratory complex I impaired cholesterol/lipid, impaired vesicle endocytosis ApoE4 Psen1 Psen2 downregulated miRNA upregulated miRNA upregulated target translation downregulated target translation neurovascular coupling AD susceptibility genes ---> neuroinflam mation cerebral hypoperfusion mitochondria dynamics pathway ---> synaptic dysfunction, synapse loss, cognitive decline LTP toxic Abeta ---| LTP toxic Abeta ---| neurovascular coupling toxic Abeta --+> neuroinflam mation toxic Abeta toxic Abeta --+> LTD LTD LTD ---> synaptic dysfunction, synapse loss, cognitive decline synaptic dysfunction, synapse loss, cognitive decline hyperphosphorylated Tau ---> synaptic dysfunction, synapse loss, cognitive decline glucose hypometabolism oxidative stress ---| glycolysis pathway astrogliosis tau kinases tau phosphatases Abeta degrading enzymes Abeta interacting partners respiratory complex IV respiratory complex I electron transport chain pathway mitochondria dynamics pathway glycolysis pathway gamma-secretase Alzheimer's Disease (AD) early-onset, familial AD AD type 4 AD type 1 late-onset, sporadic AD AD type 2
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Genes in Pathway:


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Alzheimer's disease pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISS RGD PMID:9697696 RGD:1302534 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 IEA KEGG rno:05010 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 IEA KEGG rno:05010 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 IEA KEGG rno:05010 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Apbb1 amyloid beta precursor protein binding family B member 1 IEA KEGG rno:05010 NCBI chr 1:159,896,889...159,920,505
Ensembl chr 1:159,896,880...159,920,627
JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit IEA KEGG rno:05010 NCBI chr 2:183,437,676...183,443,113
Ensembl chr 2:183,438,434...183,441,955
JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit IEA KEGG rno:05010 NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243
JBrowse link
G Apoe apolipoprotein E IEA KEGG rno:05010 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G App amyloid beta precursor protein IEA KEGG rno:05010 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Atf6 activating transcription factor 6 IEA KEGG rno:05010 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 IEA KEGG rno:05010 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 IEA KEGG rno:05010 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 IEA KEGG rno:05010 NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha IEA KEGG rno:05010 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta IEA KEGG rno:05010 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma IEA KEGG rno:05010 NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367
JBrowse link
G Atp5f1d ATP synthase F1 subunit delta IEA KEGG rno:05010 NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929
JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon IEA KEGG rno:05010 NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450
JBrowse link
G Atp5hl1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d-like 1 IEA KEGG rno:05010 NCBI chr16:48,628,349...48,628,948
Ensembl chr16:48,628,407...48,628,892
JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 IEA KEGG rno:05010 NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124
Ensembl chr10:81,023,925...81,027,124
JBrowse link
G Atp5mc1l2 ATP synthase membrane subunit c locus 1 like 2 IEA KEGG rno:05010 NCBI chr 6:66,654,187...66,654,763
Ensembl chr 6:66,654,294...66,654,692
JBrowse link
G Atp5mc2 ATP synthase membrane subunit c locus 2 IEA KEGG rno:05010 NCBI chr 7:133,791,341...133,799,713
Ensembl chr 7:133,791,342...133,799,733
JBrowse link
G Atp5mc3 ATP synthase membrane subunit c locus 3 IEA KEGG rno:05010 NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279
JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b IEA KEGG rno:05010 NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d IEA KEGG rno:05010 NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 IEA KEGG rno:05010 NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP IEA KEGG rno:05010 NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592
JBrowse link
G Bace1 beta-secretase 1 IEA KEGG rno:05010 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Bace2 beta-secretase 2 IEA KEGG rno:05010 NCBI chr11:36,707,447...36,789,550
Ensembl chr11:36,707,458...36,789,546
JBrowse link
G Bad BCL2-associated agonist of cell death IEA KEGG rno:05010 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bid BH3 interacting domain death agonist IEA KEGG rno:05010 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C IEA KEGG rno:05010 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D IEA KEGG rno:05010 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F IEA KEGG rno:05010 NCBI chr  X:14,868,096...14,896,413
Ensembl chr  X:14,868,024...14,896,413
JBrowse link
G Cacna1s calcium voltage-gated channel subunit alpha1 S IEA KEGG rno:05010 NCBI chr13:47,493,949...47,564,194
Ensembl chr13:47,493,949...47,564,318
JBrowse link
G Calm1 calmodulin 1 IEA KEGG rno:05010 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
JBrowse link
G Calm2 calmodulin 2 IEA KEGG rno:05010 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287
JBrowse link
G Calm3 calmodulin 3 IEA KEGG rno:05010 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
JBrowse link
G Calml3 calmodulin-like 3 IEA KEGG rno:05010 NCBI chr17:66,419,844...66,423,083
Ensembl chr17:66,419,882...66,423,175
JBrowse link
G Calml5 calmodulin-like 5 IEA KEGG rno:05010 NCBI chr17:66,394,433...66,395,352 JBrowse link
G Capn1 calpain 1 IEA KEGG rno:05010 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
JBrowse link
G Capn2 calpain 2 IEA KEGG rno:05010 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Casp12 caspase 12 IEA KEGG rno:05010 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 IEA KEGG rno:05010 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 IEA KEGG rno:05010 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 IEA KEGG rno:05010 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 IEA KEGG rno:05010 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdk5 cyclin-dependent kinase 5 IEA KEGG rno:05010 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 IEA KEGG rno:05010 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
JBrowse link
G Chp1 calcineurin-like EF-hand protein 1 IEA KEGG rno:05010 NCBI chr 3:106,536,009...106,571,255
Ensembl chr 3:106,536,004...106,571,251
JBrowse link
G Chp1l1 calcineurin-like EF-hand protein 1 like 1 IEA KEGG rno:05010 NCBI chr 5:68,570,894...68,571,875
Ensembl chr 5:68,571,232...68,571,819
JBrowse link
G Chp2 calcineurin-like EF hand protein 2 IEA KEGG rno:05010 NCBI chr 1:176,757,945...176,772,443
Ensembl chr 1:176,757,876...176,772,139
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 IEA KEGG rno:05010 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cox4i2 cytochrome c oxidase subunit 4i2 IEA KEGG rno:05010 NCBI chr 3:141,228,443...141,239,337
Ensembl chr 3:141,228,443...141,239,331
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A IEA KEGG rno:05010 NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781
JBrowse link
G Cox5b cytochrome c oxidase subunit 5B IEA KEGG rno:05010 NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
JBrowse link
G Cox6a1 cytochrome c oxidase subunit 6A1 IEA KEGG rno:05010 NCBI chr12:41,261,983...41,265,037
Ensembl chr12:41,261,967...41,265,041
JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 IEA KEGG rno:05010 NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274
JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 IEA KEGG rno:05010 NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001
Ensembl chr 2:85,875,109...85,884,001
JBrowse link
G Cox6b2 cytochrome c oxidase subunit 6B2 IEA KEGG rno:05010 NCBI chr 1:69,094,009...69,095,312 JBrowse link
G Cox6c cytochrome c oxidase subunit 6C IEA KEGG rno:05010 NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963
JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 IEA KEGG rno:05010 NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633
Ensembl chr 8:51,301,168...51,301,633
JBrowse link
G Cox7a2l cytochrome c oxidase subunit 7A2 like IEA KEGG rno:05010 NCBI chr 6:11,184,064...11,198,287
Ensembl chr 6:11,184,285...11,198,273
JBrowse link
G Cox7a2l2 cytochrome c oxidase subunit VIIa polypeptide 2-like 2 IEA KEGG rno:05010 NCBI chr14:51,301,169...51,301,612
Ensembl chr14:51,301,168...51,301,633
Ensembl chr 8:51,301,168...51,301,633
JBrowse link
G Cox7b cytochrome c oxidase subunit 7B IEA KEGG rno:05010 NCBI chr  X:71,083,486...71,089,733
Ensembl chr  X:71,083,456...71,089,732
JBrowse link
G Cox7c cytochrome c oxidase subunit 7C IEA KEGG rno:05010 NCBI chr 2:16,841,771...16,843,796
Ensembl chr 2:16,840,837...16,843,760
JBrowse link
G Cox8a cytochrome c oxidase subunit 8A IEA KEGG rno:05010 NCBI chr 1:204,402,118...204,404,439 JBrowse link
G Cox8b cytochrome c oxidase, subunit VIIIb IEA KEGG rno:05010 NCBI chr 1:195,977,183...195,978,643 JBrowse link
G Cox8c cytochrome c oxidase subunit 8C IEA KEGG rno:05010 NCBI chr 6:122,028,566...122,029,889
Ensembl chr 6:122,028,566...122,029,889
JBrowse link
G Cyc1 cytochrome c-1 IEA KEGG rno:05010 NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479
JBrowse link
G Cycs cytochrome c, somatic IEA KEGG rno:05010 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyct cytochrome c, testis IEA KEGG rno:05010 NCBI chr 3:61,290,090...61,297,158
Ensembl chr 3:60,913,562...61,297,158
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 IEA KEGG rno:05010 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 IEA KEGG rno:05010 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Fadd Fas associated via death domain IEA KEGG rno:05010 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor IEA KEGG rno:05010 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase IEA KEGG rno:05010 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gapdh-ps118 Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 118 IEA KEGG rno:05010 NCBI chr18:61,626,988...61,628,224
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gapdhl10 glyceraldehyde-3-phosphate dehydrogenase like 10 IEA KEGG rno:05010 NCBI chr16:15,370,290...15,371,300
Ensembl chr16:15,370,293...15,371,300
JBrowse link
G Gapdhl3 glyceraldehyde-3-phosphate dehydrogenase like 3 IEA KEGG rno:05010 NCBI chr15:77,324,675...77,471,131 JBrowse link
G Gapdhl9 glyceraldehyde-3-phosphate dehydrogenase like 9 IEA KEGG rno:05010 NCBI chr 2:210,784,633...210,785,652 JBrowse link
G Gnaq G protein subunit alpha q IEA KEGG rno:05010 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 IEA KEGG rno:05010 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A IEA KEGG rno:05010 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B IEA KEGG rno:05010 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C IEA KEGG rno:05010 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427
JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D IEA KEGG rno:05010 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IEA KEGG rno:05010 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 IEA KEGG rno:05010 NCBI chr  X:21,089,142...21,091,603
Ensembl chr  X:21,089,122...21,109,488
JBrowse link
G Ide insulin degrading enzyme IEA KEGG rno:05010 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440
JBrowse link
G Il1b interleukin 1 beta IEA KEGG rno:05010 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 IEA KEGG rno:05010 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 IEA KEGG rno:05010 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 IEA KEGG rno:05010 NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337
JBrowse link
G Lpl lipoprotein lipase IEA KEGG rno:05010 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrp1 LDL receptor related protein 1 IEA KEGG rno:05010 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEA KEGG rno:05010 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEA KEGG rno:05010 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapt microtubule-associated protein tau IEA KEGG rno:05010 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mme membrane metallo-endopeptidase IEA KEGG rno:05010 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Nae1 NEDD8 activating enzyme E1 subunit 1 IEA KEGG rno:05010 NCBI chr19:446,015...472,145
Ensembl chr19:446,000...472,371
JBrowse link
G Ncstn nicastrin IEA KEGG rno:05010 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 IEA KEGG rno:05010 NCBI chr  X:116,424,223...116,427,875
Ensembl chr  X:116,424,223...116,428,633
JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 IEA KEGG rno:05010 NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560
JBrowse link
G Ndufa10l1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1 IEA KEGG rno:05010 NCBI chr 6:59,879,819...59,881,252
Ensembl chr 6:59,879,312...59,881,241
JBrowse link
G Ndufa11 NADH:ubiquinone oxidoreductase subunit A11 IEA KEGG rno:05010 NCBI chr 9:1,550,487...1,554,546
Ensembl chr 9:1,550,468...1,555,601
JBrowse link
G Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 IEA KEGG rno:05010 NCBI chr 7:28,771,330...28,798,316
Ensembl chr 7:28,771,330...28,798,315
JBrowse link
G Ndufa13-ps1 NADH:ubiquinone oxidoreductase subunit A13, pseudogene 1 IEA KEGG rno:05010 NCBI chr 7:30,370,156...30,370,625
Ensembl chr 7:30,370,154...30,370,588
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 IEA KEGG rno:05010 NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076
JBrowse link
G Ndufa3 NADH:ubiquinone oxidoreductase subunit A3 IEA KEGG rno:05010 NCBI chr 1:65,597,567...65,600,197
Ensembl chr 1:65,597,578...65,600,235
JBrowse link
G Ndufa4 Ndufa4, mitochondrial complex associated IEA KEGG rno:05010 NCBI chr 4:40,002,216...40,009,384
Ensembl chr 4:40,002,216...40,023,920
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 IEA KEGG rno:05010 NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
JBrowse link
G Ndufa6 NADH:ubiquinone oxidoreductase subunit A6 IEA KEGG rno:05010 NCBI chr 7:113,866,382...113,870,239
Ensembl chr 7:113,866,382...113,870,239
JBrowse link
G Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 IEA KEGG rno:05010 NCBI chr 7:14,609,283...14,622,064
Ensembl chr 7:14,609,146...14,631,976
JBrowse link
G Ndufa8 NADH:ubiquinone oxidoreductase subunit A8 IEA KEGG rno:05010 NCBI chr 3:19,386,062...19,402,090
Ensembl chr 3:19,386,065...19,402,071
JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 IEA KEGG rno:05010 NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018
JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 IEA KEGG rno:05010 NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099
JBrowse link
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 IEA KEGG rno:05010 NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442
JBrowse link
G Ndufb11 NADH:ubiquinone oxidoreductase subunit B11 IEA KEGG rno:05010 NCBI chr  X:1,572,805...1,575,063
Ensembl chr  X:1,572,785...1,575,062
JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 IEA KEGG rno:05010 NCBI chr 4:68,367,526...68,374,609
Ensembl chr15:46,536,062...46,536,851
Ensembl chr 4:46,536,062...46,536,851
JBrowse link
G Ndufb3 NADH:ubiquinone oxidoreductase subunit B3 IEA KEGG rno:05010 NCBI chr 9:60,129,240...60,139,452
Ensembl chr 9:60,129,154...60,139,446
JBrowse link
G Ndufb4 NADH:ubiquinone oxidoreductase subunit B4 IEA KEGG rno:05010 NCBI chr11:63,063,723...63,070,426
Ensembl chr11:63,063,795...63,070,425
JBrowse link
G Ndufb4l1 NADH:ubiquinone oxidoreductase subunit B4-like 1 IEA KEGG rno:05010 NCBI chr14:6,365,872...6,366,282
Ensembl chr14:6,365,869...6,366,261
JBrowse link
G Ndufb4l3 NADH:ubiquinone oxidoreductase subunit B4 like 3 IEA KEGG rno:05010 NCBI chr 1:87,479,867...87,480,354
Ensembl chr 1:87,479,905...87,480,294
JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 IEA KEGG rno:05010 NCBI chr 2:115,519,248...115,533,589
Ensembl chr 2:115,519,154...115,533,589
JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 IEA KEGG rno:05010 NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181
JBrowse link
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 IEA KEGG rno:05010 NCBI chr19:24,568,241...24,572,579
Ensembl chr19:24,568,241...24,572,579
JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 IEA KEGG rno:05010 NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817
JBrowse link
G Ndufb9 NADH:ubiquinone oxidoreductase subunit B9 IEA KEGG rno:05010 NCBI chr 7:90,480,948...90,487,367
Ensembl chr 7:90,436,621...90,488,009
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 IEA KEGG rno:05010 NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 IEA KEGG rno:05010 NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893
JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 IEA KEGG rno:05010 NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420
JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 IEA KEGG rno:05010 NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 IEA KEGG rno:05010 NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
JBrowse link
G Ndufs5 NADH:ubiquinone oxidoreductase subunit S5 IEA KEGG rno:05010 NCBI chr 5:135,974,029...135,979,705
Ensembl chr 5:135,974,034...135,979,603
Ensembl chr14:135,974,034...135,979,603
Ensembl chr 2:135,974,034...135,979,603
JBrowse link
G Ndufs6-ps1 NADH:ubiquinone oxidoreductase subunit S6, pseudogene 1 IEA KEGG rno:05010 NCBI chr 2:27,201,706...27,202,241
Ensembl chr 2:27,201,713...27,202,258
JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 IEA KEGG rno:05010 NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195
JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 IEA KEGG rno:05010 NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511
JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 IEA KEGG rno:05010 NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 IEA KEGG rno:05010 NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
JBrowse link
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 IEA KEGG rno:05010 NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074
Ensembl chr13:9,612,431...9,623,074
JBrowse link
G Nos1 nitric oxide synthase 1 IEA KEGG rno:05010 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Plcb1 phospholipase C beta 1 IEA KEGG rno:05010 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Plcb2 phospholipase C, beta 2 IEA KEGG rno:05010 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302
JBrowse link
G Plcb3 phospholipase C beta 3 IEA KEGG rno:05010 NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228
JBrowse link
G Plcb4 phospholipase C, beta 4 IEA KEGG rno:05010 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha IEA KEGG rno:05010 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta IEA KEGG rno:05010 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981
JBrowse link
G Ppp3cc protein phosphatase 3 catalytic subunit gamma IEA KEGG rno:05010 NCBI chr15:45,289,917...45,362,012
Ensembl chr15:45,290,373...45,361,832
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha IEA KEGG rno:05010 NCBI chr14:91,556,743...91,606,391
Ensembl chr14:91,604,121...91,606,907
JBrowse link
G Ppp3r2 protein phosphatase 3, regulatory subunit B, beta IEA KEGG rno:05010 NCBI chr 5:64,026,903...64,027,898
Ensembl chr 5:64,026,903...64,032,548
JBrowse link
G Psen1 presenilin 1 IEA KEGG rno:05010 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Psen2 presenilin 2 IEA
ISO
KEGG
RGD
PMID:11803125 rno:05010, RGD:729530 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Psenen presenilin enhancer gamma secretase subunit IEA KEGG rno:05010 NCBI chr 1:85,814,905...85,816,654
Ensembl chr 1:85,814,905...85,816,192
JBrowse link
G RGD1565588 similar to calcium binding protein P22 IEA KEGG rno:05010
G Ryr3 ryanodine receptor 3 IEA KEGG rno:05010 NCBI chr 3:99,431,755...99,979,125
Ensembl chr 3:99,432,505...99,704,961
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A IEA KEGG rno:05010 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B IEA KEGG rno:05010 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
JBrowse link
G Sdhc succinate dehydrogenase complex subunit C IEA KEGG rno:05010 NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253
JBrowse link
G Sdhd succinate dehydrogenase complex subunit D IEA KEGG rno:05010 NCBI chr 8:50,944,702...50,954,298
Ensembl chr 8:50,944,704...50,954,238
JBrowse link
G Snca synuclein alpha IEA
ISO
KEGG
RGD
PMID:11572944 rno:05010, RGD:1302528 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Tnf tumor necrosis factor IEA KEGG rno:05010 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEA KEGG rno:05010 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Uba1y ubiquitin-activating enzyme, Chr Y IMP RGD PMID:11020223 RGD:1302873 NCBI chr  Y:457,617...480,306
Ensembl chr  Y:459,843...480,216
JBrowse link
G Ube2d2b ubiquitin-conjugating enzyme E2D 2B IMP RGD PMID:11020223 RGD:1302873 NCBI chr14:1,915,999...1,917,473
Ensembl chr14:1,916,845...1,917,416
JBrowse link
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 IMP RGD PMID:11020223 RGD:1302873 NCBI chr 2:223,868,397...223,899,606
Ensembl chr 2:223,868,730...223,898,081
JBrowse link
G Ube2g1 ubiquitin-conjugating enzyme E2G 1 IMP RGD PMID:11020223 RGD:1302873 NCBI chr10:57,225,963...57,306,748
Ensembl chr10:57,225,952...57,308,568
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I IMP RGD PMID:11020223 RGD:1302873 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443
JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N IMP RGD PMID:11020223 RGD:1302873 NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355
JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein IEA KEGG rno:05010 NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150
JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 IEA KEGG rno:05010 NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 IEA KEGG rno:05010 NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 IEA KEGG rno:05010 NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479
JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein IEA KEGG rno:05010 NCBI chr 5:129,545,978...129,554,173
Ensembl chr 5:129,545,984...129,554,242
JBrowse link
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII IEA KEGG rno:05010 NCBI chr10:37,585,864...37,589,328
Ensembl chr10:37,586,888...37,589,169
JBrowse link

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Grouppotential Alzheimer's Disease miRNAs

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Alzheimer's disease pathway
Disease TermsGene Symbols
abdominal aortic aneurysmApoe , Casp3 , Il1b
abdominal obesity-metabolic syndrome 1Atp2a2 , Fadd , Fas , Lpl
Aberrant Crypt FociGsk3b , Mapk1 , Mapk3
achalasiaNos1
achondrogenesis type IACalm1 , Cox8c
achromatopsiaAtf6
achromatopsia 7Atf6
acneTnf , Tnfrsf1a
acquired immunodeficiency syndromeTnf , Tnfrsf1a
acrodermatitisItpr3
acrokeratosis verruciformisAtp2a2
acromesomelic dysplasia, Maroteaux typeNdufb6
Acute Coronary SyndromeGapdh , Tnf
Acute Experimental PancreatitisAtp2a2 , Fas , Tnf , Tnfrsf1a
Acute HepatitisTnf
acute kidney failureA2m , Atp5f1b , Bad , Capn1 , Fas , Gsk3b , Il1b , Ndufb8 , Nos1 , Tnf , Tnfrsf1a
Acute Liver FailureCasp12 , Casp3 , Casp8 , Casp9 , Fas , Lrp1 , Tnf
Acute Lung InjuryCasp12 , Casp3 , Casp8 , Ern1 , Fadd , Fas , Il1b , Tnf
acute lymphoblastic leukemiaCasp8 , Fas
acute myeloid leukemiaCapn2 , Casp7 , Fadd , Fas , Plcb1
acute myocardial infarctionCasp3 , Casp7 , Gsk3b , Il1b , Ndufb5 , Sdhb , Tnf
acute necrotizing pancreatitisCasp3 , Il1b , Nos1
acute stress disorderCacna1c
Acute-On-Chronic Liver FailureEif2ak3 , Ern1
Adams-Oliver Syndrome 5Grin1
adenocarcinomaApoe , Casp8 , Il1b , Tnf
adenomaAtp2a3 , Cacna1d
adenylosuccinase lyase deficiencyNdufa6
adult respiratory distress syndromeIl1b , Tnf , Tnfrsf1a
adult T-cell leukemia/lymphomaFas
age related macular degeneration 1Apoe
Aggressive FibromatosisTnf
agranulocytosisIl1b
Aicardi-Goutieres Syndrome 1Uqcrc1
Aicardi-Goutieres Syndrome 3Capn1 , Fadd , Ndufs8 , Ndufv1
AIDS Dementia ComplexIl1b
Alagille syndromePlcb1 , Plcb4
ALAGILLE SYNDROME 1Plcb1 , Plcb4
Aland Island eye diseaseCacna1f
AlbuminuriaGnaq , Il1b , Tnf
alcohol dependenceCacna1c , Grin2a , Mapk1 , Mapk3
Alcohol MyopathyAtp2a1
alcohol use disorderGrin1 , Grin2b , Mapk1 , Mapk3 , Snca
Alcohol Withdrawal SeizuresCacna1d
Alcohol-Related DisordersCasp8
alcoholic cardiomyopathyNos1
Alcoholic Fatty LiverTnf
alcoholic hepatitisFas , Tnf
alcoholic liver cirrhosisTnf
Alcoholic Liver DiseasesFas , Il1b , Lpl , Tnf
allergic bronchopulmonary aspergillosisTnf , Tnfrsf1a
allergic conjunctivitisIl1b
allergic contact dermatitisCasp8 , Tnf
allergic diseaseIl1b , Tnf , Tnfrsf1a
allergic rhinitisIl1b
alpha thalassemia-X-linked intellectual disability syndromeCox7b
Alport syndromeIl1b
Alveolar Bone LossIl1b , Tnf
Alzheimer's diseaseA2m , Adam10 , Adam17 , Apbb1 , Aph1a , Aph1b , Apoe , App , Atp5f1a , Atp5f1d , Atp5pf , Atp5po , Bace1 , Bace2 , Bad , Cacna1c , Calm1 , Calml5 , Capn1 , Capn2 , Casp12 , Casp3 , Casp7 , Casp8 , Casp9 , Cdk5 , Cdk5r1 , Cox7c , Fadd , Fas , Gapdh , Grin1 , Grin2a , Grin2b , Gsk3b , Hsd17b10 , Ide , Il1b , Itpr1 , Lpl , Lrp1 , Mapk1 , Mapk3 , Mapt , Mme , Nae1 , Ncstn , Ndufa2 , Ndufa5 , Ndufa6 , Ndufb3 , Ndufb8 , Ndufs3 , Nos1 , Plcb1 , Ppp3r1 , Psen1 , Psen2 , Snca , Tnf , Tnfrsf1a , Uqcrc1
Alzheimer's disease 1App
Alzheimer's disease 18Adam10
Alzheimer's disease 2Apoe
Alzheimer's disease 3Apoe , Psen1
Alzheimer's disease 4Apoe , Psen1 , Psen2
Alzheimer's Disease, Early-Onset, with Cerebral Amyloid AngiopathyApp , Atp5pf
Alzheimer's Disease, Familial, 3, with Spastic ParaparesisPsen1
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and ApraxiaApoe , Psen1
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Unusual PlaquesPsen1
Amebic Liver AbscessTnf
amenorrheaRyr3
amnestic disorderApp
amphetamine abuseCdk5 , Nos1 , Snca
Amyloid AngiopathyApp
Amyloid NeuropathiesApp , Psen1
Amyloid PlaquesApp , Psen1
amyloidosisApoe , App , Cacna1c , Psen1 , Tnf , Tnfrsf1a
amyotrophic lateral sclerosisApoe , Bad , Bid , Casp12 , Casp3 , Casp9 , Cdk5 , Gsk3b , Itpr2 , Tnf
amyotrophic lateral sclerosis type 1Atp5po , Tnf
anemiaIl1b , Tnf , Tnfrsf1a
angle-closure glaucomaApoe
Animal Disease ModelsApp , Cacna1d , Fas , Gapdh , Grin1 , Il1b , Itpr3 , Mapk1 , Mapk3 , Mapt , Psen1 , Snca , Tnf
Animal LamenessSnca
Animal Mammary NeoplasmsLpl , Ube2i
anogenital venereal wartTnf
AnorexiaIl1b , Tnf , Tnfrsf1a
anterior segment dysgenesisItpr1
anterior uveitisTnf
anthracosisIl1b , Tnf
Anthracycline-induced CardiotoxicityCapn2
anthrax diseaseIl1b , Tnf
anti-basement membrane glomerulonephritisIl1b , Tnf
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisFas , Tnf , Tnfrsf1a
antisynthetase syndromeIl1b
anxiety disorderApoe , App , Cacna1c , Mapt , Tnf
aortic atherosclerosisApoe , Capn1
Aortic CalcificationAtp5f1d
aortic valve stenosisPpp3cb , Tnf
aplastic anemiaFas , Tnf
Apolipoprotein E, Deficiency or Defect ofApoe
APP-related cerebral amyloid angiopathyApp
arrhythmogenic right ventricular cardiomyopathyCacna1c
Arsenic PoisoningIl1b , Ndufb8 , Tnf
arteriosclerosisApoe , Il1b , Lrp1 , Ndufs6-ps1 , Nos1 , Tnfrsf1a
arthrogryposis multiplex congenitaRyr3
Arthrogryposis, Cleft Palate, Craniosynostosis, and Impaired Intellectual DevelopmentPpp3ca
asbestosisAtf6 , Il1b , Tnf
asphyxia neonatorumPsen1 , Psen2
aspiration pneumoniaTnf
asthmaFas , Il1b , Itpr1 , Nos1 , Tnf , Tnfrsf1a
astigmatismGrin2b
AtaxiaGrin2b , Itpr1 , Mapt , Snca
ataxia telangiectasiaCasp12 , Sdhd
atherosclerosisApoe , Casp3 , Fas , Il1b , Tnf
Atkin SyndromeHsd17b10
atopic dermatitisAdam17 , Apoe , Casp8 , Il1b , Tnf
atrial fibrillationMapt , Tnf
atrophic gastritisIl1b
atrophoderma vermiculataLrp1
AtrophyMapk3
attention deficit hyperactivity disorderCdk5r1 , Grin2b
Auriculocondylar SyndromePlcb4
Auriculocondylar Syndrome 1Plcb4
Auriculocondylar Syndrome 2Plcb4
autism spectrum disorderCacna1c , Cacna1d , Grin1 , Grin2b , Itpr3 , Lrp1 , Mapk1 , Mapk3 , Nos1 , Ppp3ca
autistic disorderBace2 , Cacna1c , Cacna1f , Cox7b , Grin1 , Grin2a , Grin2b , Hsd17b10 , Itpr3 , Mapk3 , Ndufa1 , Ndufa7 , Ndufb11 , Tnf , Uqcrc2
autoimmune diseaseCasp8 , Fas , Tnfrsf1a
autoimmune hepatitisFas , Tnf
autoimmune interstitial lung, joint, and kidney diseaseAtf6 , Ncstn , Ndufs2 , Sdhc
autoimmune lymphoproliferative syndromeCasp8 , Fas
autoimmune lymphoproliferative syndrome type 2BCasp8 , Ndufb3
Autoimmune Lymphoproliferative Syndrome, Type IAFas
Autoimmune Lymphoproliferative Syndrome, Type VCasp8 , Ndufb3
autoimmune thrombocytopenic purpuraFas
autoimmune thyroiditisTnf
autosomal dominant cerebellar ataxiaItpr1
Autosomal Dominant Diffuse Lewy Body DiseaseSnca
autosomal dominant dyskeratosis congenita 6Nae1
autosomal dominant familial periodic feverTnfrsf1a
autosomal dominant intellectual developmental disorderGrin2b
autosomal dominant intellectual developmental disorder 21Grin2a
autosomal dominant intellectual developmental disorder 31Ndufa2
autosomal dominant intellectual developmental disorder 5Itpr3
autosomal dominant intellectual developmental disorder 6Grin2b
autosomal dominant intellectual developmental disorder 7Atp5po
autosomal dominant intellectual developmental disorder 8Grin1
autosomal dominant nocturnal frontal lobe epilepsy 5Grin1
autosomal dominant polycystic kidney diseaseSnca
autosomal recessive limb-girdle muscular dystrophy type 2JNdufa9
autosomal recessive nonsyndromic deafness 22Uqcrc2
autosomal recessive pseudohypoaldosteronism type 1Tnfrsf1a
azoospermiaHsd17b10
B-Cell Chronic Lymphocytic LeukemiaApoe , Fas , Il1b , Tnf
B-lymphoblastic leukemia/lymphoma with hypodiploidySdha
background diabetic retinopathyA2m
bacterial infectious diseaseCasp3 , Casp8 , Casp9
bacterial pneumoniaIl1b , Tnf , Tnfrsf1a
Bannayan-Riley-Ruvalcaba syndromeSdhb
Bardet-Biedl syndromeCapn1
Barrett's esophagusFas
Behcet's diseaseFas , Il1b , Tnf , Tnfrsf1a
benign epilepsy with centrotemporal spikesGrin1 , Grin2a , Plcb1
berylliosisTnf
beta thalassemiaApoe , Tnf
beta-mannosidosisPpp3ca , Ube2d3
Bethlem Myopathy 1ANdufa10
BH4-deficient hyperphenylalaninemia ASdhd
bilateral breast cancerSdhb
bile duct cancerApoe
bilirubin metabolic disorderTnf
bipolar disorderCacna1c , Cacna1d , Grin2a , Grin2b , Gsk3b , Ndufs7 , Ndufv2 , Snca
Blast InjuriesApp
BlisterAdam17
blood coagulation diseaseGnaq
Bloom syndromeAdam10 , Aph1b , Chp1 , Cox5a , Plcb2 , Ryr3
borna diseaseAtf6
BradycardiaCacna1d
Brain ContusionCasp3 , Casp8
brain diseaseApp , Cdk5r1 , Grin2d , Ndufs4
brain edemaTnf
brain gliomaCasp3 , Fadd , Fas , Gapdh
Brain HypoxiaAdam17 , Itpr1 , Itpr2
Brain Hypoxia-IschemiaCasp12 , Casp3 , Casp8 , Casp9 , Cdk5r1 , Fadd , Fas , Grin1 , Grin2a , Grin2b , Il1b , Mapt
brain infarctionIl1b , Tnf
Brain InjuriesApaf1 , Apbb1 , Apoe , App , Atp5pd , Bad , Casp12 , Casp3 , Casp8 , Fas , Gsk3b , Il1b , Ppp3ca , Snca , Tnf , Tnfrsf1a
brain ischemiaApaf1 , Bad , Casp12 , Casp3 , Casp9 , Cdk5 , Cycs , Fas , Il1b , Mapk1 , Mapk3 , Mapt , Nos1 , Tnf , Tnfrsf1a
branched-chain keto acid dehydrogenase kinase deficiencyCox6a2
breast adenocarcinomaTnf
breast cancerApoe , Bad , Casp3 , Casp7 , Casp8 , Casp9 , Fas , Il1b , Mapk1 , Mapt , Psen2 , Sdhb , Sdhc , Tnf
Breast Cancer, FamilialCasp8 , Ndufab1 , Sdha
breast carcinomaCasp3 , Fas
breast ductal carcinomaCacna1c
Breast NeoplasmsAdam10 , Casp7 , Casp8 , Gsk3b , Il1b , Mme , Ndufs3 , Psen2 , Tnf
Broad-BetalipoproteinemiaApoe
Brody myopathyAtp2a1
Bronchial HyperreactivityIl1b , Nos1 , Tnf
bronchiectasisIl1b , Tnf
bronchiectasis 1Tnfrsf1a
bronchiolitisIl1b
bronchopulmonary dysplasiaBid , Casp3 , Casp8 , Casp9 , Il1b , Tnf
Brown-Vialetto-Van Laere syndrome 2Cyc1
Brugada syndromeCacna1c
Brugada syndrome 3Cacna1c
Brugada syndrome 5Cox6b1 , Psenen
Burnett Schwartz Berberian SyndromeLrp1
BurnsA2m , Bad , Casp3 , Gsk3b , Il1b , Tnf
CachexiaAtp2a1 , Atp2a2 , Il1b , Tnf , Tnfrsf1a
calcinosisCasp3 , Il1b , Tnf
cannabis abuseCalm1 , Calm2
Carbon Monoxide PoisoningNos1
Carbon Tetrachloride PoisoningFadd
carcinomaLpl , Ube2i
cardiac arrestItpr1 , Tnf
Cardiac ArrhythmiasCacna1c
CardiomegalyA2m , Atp2a2 , Atp5f1d , Bad , Cox5b , Gnaq , Gsk3b , Il1b , Itpr2 , Mapk1 , Ndufs3 , Nos1 , Ppp3ca , Tnf
cardiomyopathyAdam10 , App , Atp5f1b , Cacna1c , Fas , Il1b , Lpl , Lrp1 , Mapk1 , Mapk3 , Mapt , Ndufs2 , Ndufv2 , Nos1 , Psen1 , Tnf , Uqcrfs1
CardiotoxicityFas , Il1b , Tnf
Cardiovascular AbnormalitiesGnaq
Cardiovascular Pregnancy ComplicationsFas , Tnf
cardiovascular system diseaseApoe , Lpl
Cardiovirus InfectionsTnf
Carney TriadSdha , Sdhb , Sdhc
Carney-Stratakis syndromeSdhb , Sdhc , Sdhd
carotid artery diseaseApoe
Carotid Body TumorSdhb , Sdhd
carotid stenosisApoe
cataractAdam10 , Casp3 , Casp9 , Fas , Ndufb3
cataract 5 multiple typesNae1
cataract 9 multiple typesNdufv3
catecholaminergic polymorphic ventricular tachycardiaCacna1c , Calm1
catecholaminergic polymorphic ventricular tachycardia 1Calm1
catecholaminergic polymorphic ventricular tachycardia 4Calm1
CD3epsilon deficiencyBace1
celiac diseaseLpl
Central Nervous System Viral DiseasesGrin2a
cerebellar ataxiaItpr1
cerebellar ataxia type 43Mme
cerebellar diseaseNos1
cerebral amyloid angiopathyApoe , App , Mme , Psen1
cerebral creatine deficiency syndromeAtp5f1d , Ndufs7
Cerebral HemorrhageApoe , Casp12 , Casp3 , Casp8 , Casp9 , Il1b , Psen1 , Tnf
cerebral infarctionA2m , Apoe , Grin1 , Il1b , Tnf
cerebral palsyCacna1c , Grin2b
cerebrovascular diseaseApoe
cervical cancerCasp3 , Il1b , Ndufs6-ps1 , Tnf
cervix uteri carcinoma in situIl1b
Charcot-Marie-Tooth diseaseMme , Sdhc
Charcot-Marie-Tooth disease axonal type 2TMme
Charcot-Marie-Tooth disease dominant intermediate CNdufs5
Charcot-Marie-Tooth disease dominant intermediate DSdhc
Charcot-Marie-Tooth disease intermediate typeSdhc
Charcot-Marie-Tooth disease recessive intermediate DCox6a1
Charcot-Marie-Tooth disease type 1Atf6 , Sdhc
Charcot-Marie-Tooth disease type 1BSdhc
Charcot-Marie-Tooth disease type 1CGrin2a
Charcot-Marie-Tooth Disease Type 1JItpr3
Charcot-Marie-Tooth disease type 2Mme
Charcot-Marie-Tooth disease type 2ISdhc
Charcot-Marie-Tooth disease type 4ESdhc
CHARGE syndromeTnfrsf1a
Chediak-Higashi syndromeTnfrsf1a
Chemical and Drug Induced Liver InjuryApoe , Bad , Casp8 , Ern1 , Fadd , Fas , Il1b , Itpr1 , Lpl , Ndufs3 , Tnf
Chemical BurnsIl1b
chemical colitisCasp3 , Casp7
Chemically-Induced DisordersIl1b , Tnf
Chest TraumaFas
childhood pilocytic astrocytomaMapk1
chlamydiaTnf
ChloracneCycs
cholangiocarcinomaCycs , Il1b , Ppp3ca
cholelithiasisApoe
cholestasisApoe , Tnf
cholesteatomaIl1b
cholesteatoma of middle earTnf
chorioamnionitisFas , Tnf
Chromosome 11, Partial Trisomy 11qBace1 , Casp12 , Sdhd
chromosome 16p11.2 deletion syndrome, 220-kbAtp2a1
chromosome 16p11.2 deletion syndrome, 593-kbAtp2a1 , Mapk3
chromosome 16p11.2 duplication syndromeMapk3
chromosome 16p12.1 deletion syndromeUqcrc2
chromosome 18p deletion syndromeNdufv2
chromosome 1p36 deletion syndromeCasp9 , Sdhb
chromosome 22q11.2 deletion syndrome, distalMapk1
chromosome 2q37 deletion syndromeNdufa10
Chronic Allograft DysfunctionTnf
Chronic Brain InjuryApoe
Chronic Cerebral HypoperfusionApoe , App , Bace1
chronic conjunctivitisFas
Chronic Experimental PancreatitisIl1b
Chronic HepatitisCasp3
Chronic Hepatitis BApoe , Eif2ak3
Chronic Hepatitis CApoe , Tnf , Tnfrsf1a
Chronic Intermittent HypoxiaFadd , Il1b , Lpl , Tnf
chronic kidney diseaseIl1b
chronic myeloid leukemiaFas , Il1b , Ncstn
chronic obstructive pulmonary diseaseCasp12 , Casp3 , Casp8 , Fas , Grin2b , Il1b , Nos1 , Tnf , Tnfrsf1a
Chronic PancreatitisBad
chronic progressive external ophthalmoplegiaIl1b
chronic ulcer of skinPlcb3
Chronic UveitisFas
cicatricial pemphigoidTnf
clear cell renal cell carcinomaAtp5mc2 , Atp5pb , Atp5po
clonorchiasisFas
cocaine abuseMapk1 , Mapk3
cocaine dependenceMapk1 , Mapk3
Cocaine-Related DisordersCalm1 , Calm2 , Cdk5 , Grin1 , Mapk1 , Mapk3 , Snca
cochlear diseaseIl1b , Tnf
cognitive disorderApoe , App , Capn2 , Cdk5r1 , Grin1 , Grin2a , Grin2b , Gsk3b , Mapt , Psen1
Cognitive DysfunctionAdam10 , Apoe , App , Bace1 , Cacna1c , Ide , Il1b , Mapt , Psen1
Cohen syndromeCox6c
colitisAdam17 , Atp5f1d , Il1b , Tnf
colon adenocarcinomaCacna1d , Mapk1 , Mapk3
colon adenomaCacna1d
colon cancerApaf1 , Bad , Casp3 , Casp7 , Gsk3b , Mapk1
colon carcinomaTnfrsf1a
Colonic NeoplasmsA2m , Casp3 , Fas , Gsk3b , Il1b , Lpl , Plcb1 , Tnf
color blindnessAtf6
colorectal adenocarcinomaGsk3b , Mapk1 , Mapk3
colorectal adenomaTnfrsf1a
colorectal cancerAdam10 , Aph1b , Casp9 , Chp1 , Cox5a , Grin2a , Plcb2 , Ryr3
Colorectal NeoplasmsCasp8 , Gapdh , Grin2a , Mapk1 , Mapk3 , Tnf
combined oxidative phosphorylation deficiency 22Atp5f1a
combined oxidative phosphorylation deficiency 8Sdhd
common coldIl1b
common variable immunodeficiency 1Casp8 , Ndufb3
common variable immunodeficiency 4Ndufa6
communication disorderNdufa11
cone-rod dystrophyCacna1f
congenital diaphragmatic herniaLrp1 , Tnf
congenital disorder of glycosylation IwCacna1d
congenital disorder of glycosylation type IIcNdufs3
congenital disorder of glycosylation type IIeNdufab1
congenital disorder of glycosylation type IImCacna1f , Ndufb11
congenital heart diseaseGnaq , Mapk1
congenital hypothyroidismAtp5pd
Congenital Limb DeformitiesCacna1c
congenital myasthenic syndrome 18Plcb1 , Plcb4
Congenital MydriasisItpr1
congenital myopathy 18Cacna1s
congenital myopathy 20Ryr3
congenital myopathy 5Ndufa9
congenital nystagmusAtf6
congenital stationary night blindnessCacna1f
congenital stationary night blindness 2ACacna1f
congestive heart failureAdam17 , Apoe , Atp2a1 , Atp2a2 , Cacna1c , Casp12 , Casp3 , Fas , Gnaq , Gsk3b , Il1b , Mme , Nos1 , Snca , Tnf , Tnfrsf1a
connective tissue diseaseEif2ak3
Conotruncal Cardiac DefectsPpp3cc
contact dermatitisCasp8
ContractureRyr3
Contrast-Induced NephropathyCasp12 , Casp3 , Il1b
Copper-Overload CirrhosisCasp3
Cor pulmonaleTnf
corneal neovascularizationFas
corneal ulcerTnf
Cornelia de Lange syndrome 2Hsd17b10
coronary artery diseaseAph1b , Apoe , Il1b , Lpl , Tnf , Tnfrsf1a
Coronary DiseaseApoe , Il1b , Lpl , Lrp1
coronary restenosisMapk1 , Tnf
Coronavirus infectious diseaseMapk1 , Mapk3 , Tnf
coronin-1A deficiencyMapk3
CoughTnf
Coumarin SensitivityApoe
COVID-19A2m , Atp5f1b , Atp5f1c , Atp5mc3 , Atp5pb , Calm2 , Cdk5 , Cox5a , Gapdh , Hsd17b10 , Il1b , Lpl , Mme , Ndufb5 , Ndufs4 , Ndufs7 , Psen2 , Sdhd , Tnf , Tnfrsf1a
Cowden syndromeSdhb
Coxsackievirus InfectionsTnf
Craniofacial AbnormalitiesApaf1 , Fadd , Gnaq
Craniosynostosis Syndrome, Autosomal RecessiveGrin2b
crescentic glomerulonephritisIl1b
Creutzfeldt-Jakob diseaseAtf6 , Mapt , Snca
Crohn's diseaseTnf , Tnfrsf1a
cryoglobulinemiaTnf
Cryopyrin-Associated Periodic SyndromesMme
cryptogenic organizing pneumoniaTnfrsf1a
cryptorchidismCasp3 , Fas
CST3-related cerebral amyloid angiopathyApp
Currarino syndromeNdufb5
cutaneous leishmaniasisIl1b , Tnf
cyclic hematopoiesisAtp5f1d , Ndufs7
cystic fibrosisFas , Il1b , Ndufs1 , Nos1 , Tnf , Tnfrsf1a
cystitisIl1b , Tnf
cytochrome-c oxidase deficiency diseaseCox6b1 , Cox8a
Cytomegalovirus InfectionsTnf
cytomegalovirus retinitisTnf , Tnfrsf1a
D-2-hydroxyglutaric aciduria 1Ndufa10
Danon diseaseNdufa1
Darier Disease, Acral Hemorrhagic TypeAtp2a2
Darier Disease, SegmentalAtp2a2
DeafnessCacna1d
degenerative disc diseaseGsk3b , Tnf
DehydrationNos1
dementiaApoe , App , Bace1 , Mapt
demyelinating diseaseMapk1 , Tnf
dental cariesIl1b
depressive disorderAtp5pd , Cdk5 , Cdk5r1 , Fadd , Gsk3b , Il1b , Mapk1 , Ndufb7 , Nos1 , Snca , Uqcrb
dermatitisTnf
dermatitis herpetiformisTnf
dermatomyositisFas , Il1b , Tnf
developmental and epileptic encephalopathyRyr3
developmental and epileptic encephalopathy 1Grin1 , Plcb1
developmental and epileptic encephalopathy 101Grin1
developmental and epileptic encephalopathy 12Plcb1 , Plcb4
developmental and epileptic encephalopathy 14Grin1
developmental and epileptic encephalopathy 27Grin2b
developmental and epileptic encephalopathy 30Ndufv3
developmental and epileptic encephalopathy 46Grin2d
developmental and epileptic encephalopathy 91Ppp3ca
developmental coordination disorderNdufs4
Developmental Delay with Variable Intellectual Impairment and Behavioral AbnormalitiesNdufa6
Developmental DisabilitiesGrin1 , Grin2a , Grin2b , Lrp1 , Mapk3
Developmental DiseaseGrin2b , Grin2d , Lrp1 , Ppp3ca
developmental disorder of mental healthNdufs7
Developmental Dysplasia of the Hip 3Lrp1
Diabetes ComplicationsCasp9
diabetes mellitusApoe , Casp3 , Eif2ak3 , Itpr1 , Lrp1
diabetic angiopathyCasp3 , Fas , Tnf
Diabetic CardiomyopathiesA2m , Atf6 , Atp2a2 , Bad , Casp12 , Casp3 , Casp8 , Casp9 , Mapk1 , Mapk3 , Tnf
Diabetic CystopathyBad , Casp12
Diabetic EmbryopathyFadd
diabetic encephalopathyApp , Gsk3b , Ide
Diabetic NephropathiesApoe , Atp5f1b , Casp12 , Casp3 , Casp7 , Casp8 , Casp9 , Fas , Gsk3b , Il1b , Lpl , Mapk1 , Ndufs3 , Nos1 , Tnf , Tnfrsf1a
diabetic neuropathyBad , Casp3 , Il1b , Mme , Tnf
diabetic retinopathyApoe , Casp3 , Casp9 , Gapdh , Il1b , Nos1 , Tnf
Diaphragmatic HerniaTnf
diarrheaMme
Diastolic DysfunctionNdufb5
DICER1 syndromeCox8c
diffuse large B-cell lymphomaFas
diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtypeSdha
DiGeorge syndromeMapk1
dilated cardiomyopathyApoe , Cacna1c , Casp3 , Casp8 , Casp9 , Fas , Gnaq , Gsk3b , Itpr1 , Lpl , Ppp3r1 , Psen1 , Psen2 , Sdha , Tnf , Ube2i
dilated cardiomyopathy 1ALpl
dilated cardiomyopathy 1GGSdha
dilated cardiomyopathy 1HLpl , Tnf
dilated cardiomyopathy 1IISdhd
dilated cardiomyopathy 1UPsen1
dilated cardiomyopathy 1VPsen2
disease by infectious agentTnf
disease of cellular proliferationCapn1 , Il1b
disease of mental healthNos1
Disease ProgressionApoe , Fas , Il1b , Ndufa2 , Ndufs1 , Ndufv1 , Tnf
disseminated intravascular coagulationTnf
distal arthrogryposis type 1ANdufb6
dopamine transporter deficiency syndromeSdha
Dowling-Degos diseaseAdam10
drug allergyTnf
Drug EruptionsTnf
Drug Hypersensitivity SyndromeIl1b
Drug-Induced AgranulocytosisIl1b
Drug-Induced DyskinesiaCacna1d , Gsk3b , Mapt
Drug-Induced Immune ThrombocytopeniaIl1b
Drug-Related Side Effects and Adverse ReactionsTnf
dry eye syndromeIl1b , Tnf
Duchenne muscular dystrophyNos1
DwarfismBace1 , Mapk1
Dysbetalipoproteinemia due to Defect in Apolipoprotein E-dApoe
DyslipidemiasApoe , Lpl
dystoniaCox6b1 , Grin2b , Ndufv2 , Psenen
Eales DiseaseIl1b , Tnf
early-onset dystonia and/or spastic paraplegiaAtp5mc3
EdemaCasp3 , Casp8 , Casp9 , Il1b , Tnf
egg allergyGrin2b
Embryo LossTnfrsf1a , Ube2n
EmphysemaApoe , Tnf
encephalitisIl1b , Tnf
encephalomyelitisTnf
End Stage Liver DiseaseNos1 , Tnfrsf1a
end stage renal diseaseApoe , Il1b , Lpl , Nos1 , Tnf , Tnfrsf1a
endometrial adenocarcinomaMapk1 , Mapk3
endometrial cancerBad , Tnfrsf1a
endometrial carcinomaGsk3b , Mapk1 , Mapk3
Endometrial NeoplasmsGsk3b , Mapk3
Endometrioid CarcinomasMapk1 , Mapk3
endometriosisIl1b , Tnf
endometritisCasp3 , Casp7 , Casp9
endophthalmitisFas , Il1b , Tnf
EndotoxemiaApoe , Atp5f1a , Casp3 , Casp7 , Casp9 , Fas , Il1b , Mme , Tnf
EntamoebiasisIl1b
EnterocolitisIl1b
Enterovirus InfectionsTnfrsf1a
epidermolysis bullosa simplex with muscular dystrophyCyc1
epididymitisIl1b , Tnf
epilepsyAtp5po , Cacna1c , Cacna1d , Capn1 , Ern1 , Gapdh , Grin1 , Grin2a , Grin2b , Grin2d , Il1b , Itpr1 , Mapt , Ndufb10 , Ndufb3 , Plcb1 , Ppp3ca , Ryr3 , Tnf , Ube2i
episodic ataxia type 1Ndufa9
Episodic Ataxia Type 9Grin2a , Grin2b
episodic kinesigenic dyskinesia 1Mapk3
erythema nodosumTnf
Escherichia Coli InfectionsTnf
esophageal atresiaCacna1c
esophageal cancerIl1b
Esophageal NeoplasmsCasp8 , Fas , Gapdh
esophagitisTnf
esophagus adenocarcinomaCasp8 , Fas
esophagus squamous cell carcinomaCasp8
essential hypertensionAtp2a2 , Atp5pf , Il1b , Tnf
essential tremorMapt
euthyroid sick syndromeAtp2a2
exfoliation syndromeApoe
Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, and Calvarial HyperostosisCox4i2
Experimental Allergic AsthmaFas
Experimental ArthritisA2m , Adam10 , Adam17 , Gsk3b , Il1b , Tnf , Tnfrsf1a
Experimental Autoimmune EncephalomyelitisA2m , Adam17 , Apoe , Casp3 , Casp8 , Casp9 , Ern1 , Lrp1 , Mapt , Tnf
Experimental Autoimmune MyocarditisCasp3 , Casp8 , Casp9
Experimental Autoimmune NeuritisApp , Il1b , Tnf
Experimental Autoimmune UveitisFas
Experimental Autoimmune UveoretinitisTnfrsf1a
Experimental ColitisAdam17 , Atp5f1a , Fas , Il1b , Mapk1 , Mapk3 , Tnf , Tnfrsf1a
Experimental Diabetes MellitusApoe , Atp2a1 , Atp2a2 , Atp2a3 , Atp5f1a , Atp5f1b , Atp5pd , Atp5pf , Bad , Casp3 , Casp8 , Casp9 , Fas , Gapdh , Grin1 , Grin2b , Ide , Il1b , Lpl , Mapk1 , Mapk3 , Mapt , Ndufs2 , Ndufs3 , Nos1 , Plcb3 , Tnf , Tnfrsf1a
Experimental Liver CirrhosisA2m , Adam17 , Apaf1 , App , Casp12 , Casp7 , Ern1 , Fas , Il1b , Lpl , Mapk1 , Mapk3 , Mme , Tnf
Experimental Liver NeoplasmsFas , Mapk1 , Mapk3 , Tnf
Experimental Mammary NeoplasmsApaf1 , Apoe , Bad , Casp3 , Casp7 , Casp8 , Casp9 , Fas , Gsk3b , Lpl , Mapk1 , Mapk3 , Tnf , Ube2i
Experimental MelanomaIl1b
Experimental NeoplasmsTnf
Experimental Radiation InjuriesCasp3 , Casp8 , Casp9 , Fas , Il1b , Mapk1 , Mapk3 , Nos1 , Tnf
Experimental SeizuresUqcrfs1
extrahepatic cholestasisIl1b , Mapk1 , Mapk3 , Tnf
extrinsic allergic alveolitisIl1b , Tnf , Tnfrsf1a
Eye AbnormalitiesApaf1 , Cacna1f
Eye BurnsIl1b
eye diseaseIl1b , Tnf
Eye ManifestationsApp
Facial Nerve InjuriesNdufa5
Familial Acne Inversa 1Ncstn
Familial Acne Inversa 2Psenen
Familial Acne Inversa 3Psen1
familial adenomatous polyposis 1Ndufa2 , Uqcrq
familial adult myoclonic epilepsy 5Cacna1s
familial combined hyperlipidemiaApoe , Lpl
familial focal epilepsy with variable fociApp
familial hemiplegic migraineNcstn
Familial Hidradenitis SuppurativaNcstn , Psen1 , Psenen
Familial Hyperbeta- and PrebetalipoproteinemiaApoe
familial hypercholesterolemiaApoe
Familial Hyperchylomicronemia SyndromeLpl
familial hyperlipidemiaApoe , Lpl
familial hypertrophic cardiomyopathyCalm3
familial lipase maturation factor 1 deficiencyLpl
familial lipoprotein lipase deficiencyLpl
familial mediterranean feverIl1b , Tnfrsf1a
familial melanomaLrp1
familial multiple nevi flammeiGnaq
Familial Prostate CancerCasp8
familial temporal lobe epilepsy 1Grin2a
Familial Thoracic Aortic Aneurysm 6Fas
Familial Ventricular TachycardiaCacna1c , Calm1
Fanconi anemiaTnf
farmer's lungTnf
Febrile SeizuresCasp12 , Grin1 , Il1b , Tnfrsf1a
Female InfertilityMapk1 , Mapk3
Femur Head NecrosisA2m
fetal akinesia deformation sequence syndrome 1Ryr3
fetal alcohol spectrum disorderApoe , Grin2b , Nos1
Fetal Growth RetardationApoe , Atp5f1a , Atp5f1b , Cacna1c , Cacna1d , Casp3 , Fas , Grin2a , Grin2b , Nos1
Fetal HypoxiaNos1
FeverA2m , Il1b , Nos1 , Tnf , Tnfrsf1a
fibrosarcomaTnfrsf1a
FibrosisAdam10 , Apoe , Il1b , Tnf
Floating-BetalipoproteinemiaApoe
Fluoride PoisoningAtp5f1e , Atp5po
focal epilepsyGrin2a
Focal Epilepsy with Speech Disorder and with or without Mental RetardationGrin2a
focal segmental glomerulosclerosisCasp9 , Gnaq , Il1b , Lpl , Ppp3ca , Ppp3cb , Tnf , Tnfrsf1a
fragile X syndromeApp
frontotemporal dementiaBace2 , Mapt , Psen1
Frontotemporal Dementia and/or Amyotrophic Lateral SclerosisAdam10
frontotemporal dementia and/or amyotrophic lateral sclerosis 6Ndufb6
fructose-1,6-bisphosphatase deficiencyPpp3r2
fundus dystrophyCacna1f
Fungal Lung DiseasesTnf
GABA aminotransferase deficiencyGrin2a
galactosemiaNdufb6
gallbladder cancerApoe
Gallbladder NeoplasmsIl1b
gastric adenocarcinomaIl1b
gastric dilatationIl1b
gastric ulcerBad , Casp3 , Fas , Il1b , Mapk1 , Mapk3 , Tnf
gastritisTnf
gastrointestinal stromal tumorAph1a , Atf6 , Cacna1s , Capn2 , Ncstn , Ndufs2 , Psen2 , Sdha , Sdhb , Sdhc
gastroschisisLrp1
Gaucher's diseaseSnca , Tnf
Generalized EpilepsyGrin2a , Grin2b , Ppp3ca , Ryr3
genetic diseaseA2m , Adam10 , Adam17 , Apaf1 , Apbb1 , Aph1a , Aph1b , Apoe , App , Atf6 , Atp2a1 , Atp2a2 , Atp2a3 , Atp5f1a , Atp5f1b , Atp5f1c , Atp5f1d , Atp5mc1 , Atp5mc2 , Atp5mc3 , Atp5pb , Atp5pd , Atp5pf , Atp5po , Bace1 , Bace2 , Bad , Bid , Cacna1c , Cacna1d , Cacna1f , Cacna1s , Calm2 , Calml3 , Calml5 , Capn1 , Capn2 , Casp12 , Casp3 , Casp7 , Casp8 , Casp9 , Cdk5 , Cdk5r1 , Chp2 , Cox4i1 , Cox4i2 , Cox5a , Cox5b , Cox6a1 , Cox6a2 , Cox6b1 , Cox6b2 , Cox6c , Cox7a2 , Cox8c , Cyc1 , Eif2ak3 , Ern1 , Fadd , Fas , Gapdh , Gnaq , Grin1 , Grin2a , Grin2b , Grin2c , Grin2d , Gsk3b , Hsd17b10 , Ide , Il1b , Itpr1 , Itpr2 , Itpr3 , Lpl , Lrp1 , Mapk1 , Mapk3 , Mapt , Mme , Nae1 , Ncstn , Ndufa1 , Ndufa10 , Ndufa11 , Ndufa12 , Ndufa2 , Ndufa3 , Ndufa4 , Ndufa5 , Ndufa6 , Ndufa7 , Ndufa8 , Ndufa9 , Ndufab1 , Ndufb10 , Ndufb11 , Ndufb2 , Ndufb3 , Ndufb4 , Ndufb5 , Ndufb6 , Ndufb7 , Ndufb8 , Ndufb9 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs5 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2 , Ndufv3 , Nos1 , Plcb1 , Plcb2 , Plcb3 , Plcb4 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r2 , Psen1 , Psen2 , Psenen , Ryr3 , Sdha , Sdhb , Sdhd , Snca , Tnf , Tnfrsf1a , Ube2d2b , Ube2n , Uqcrb , Uqcrc1 , Uqcrc2 , Uqcrfs1 , Uqcrh , Uqcrq
Genetic Predisposition to DiseaseCacna1c , Il1b , Ppp3cc
Genetic TranslocationApoe
gestational diabetesItpr1 , Itpr2 , Itpr3 , Ryr3
Gillespie syndromeItpr1
glaucomaApoe , Bad , Fas , Tnf
glioblastomaIl1b
GliosisApp , Mapk1 , Mapk3 , Mapt , Psen1
glomerulonephritisApoe , Fas , Il1b , Mapk1 , Tnf , Tnfrsf1a
glomerulosclerosisApoe , Il1b
Glomus Jugulare TumorSdhd
glycogen storage disease VCapn1
Glycogen Storage Disease XIIMapk3
GM2 gangliosidosisSnca
goutIl1b
graft-versus-host diseaseFas
Gram-Negative Bacterial InfectionsIl1b
Graves ophthalmopathyTnf
Graves' diseaseFas , Il1b , Tnf
guanidinoacetate methyltransferase deficiencyNdufs7
Habitual AbortionsApoe
HallucinationsPsen1
Hashimoto DiseaseFas
Head and Neck NeoplasmsMapk1 , Mapk3
head and neck squamous cell carcinomaCasp8 , Mapk1
Hearing LossApoe , Cacna1d , Tnf
Hearing Loss, Cisplatin-InducedGsk3b
Hearing Loss, Noise-InducedTnf
Heart BlockCacna1c , Cacna1d
heart diseaseA2m , Atp2a2 , Atp5pf , Casp12 , Casp3 , Casp8 , Casp9 , Gsk3b
Heart InjuriesIl1b , Tnf
heart valve diseaseCasp3 , Il1b , Tnf
Heat StrokeIl1b , Nos1 , Tnf
Helicobacter InfectionsIl1b
HELLP syndromeFas
hematopoietic system diseaseFas
HemimegalencephalyGrin1
hemochromatosisTnf
hemolytic anemiaA2m
hemolytic-uremic syndromeIl1b , Tnf
hemorrhagic diseaseCycs
Hemorrhagic ShockBad , Casp3 , Casp8 , Il1b , Mapk1 , Tnf
hepatic encephalopathyNos1 , Tnf
hepatitis ATnf
hepatitis BFas , Tnf
hepatitis CIl1b , Lpl
hepatoblastomaFas
hepatocellular adenomaA2m
hepatocellular carcinomaA2m , Apoe , Atp5pb , Atp5pd , Bid , Calml3 , Casp3 , Casp8 , Casp9 , Ern1 , Fas , Gapdh , Il1b , Mapk1 , Mapt , Mme , Ryr3 , Tnf
hepatopulmonary syndromeTnf
hepatorenal syndromeTnf
hereditary breast ovarian cancer syndromeMme
hereditary fructose intolerance syndromePpp3r2
hereditary hemorrhagic telangiectasiaTnf
Hereditary Hemorrhagic Telangiectasia, Type 1Psen1
Hereditary Neoplastic SyndromesNdufa2 , Sdha , Sdhb , Sdhc , Sdhd , Uqcrq
hereditary neuropathy with liability to pressure palsiesCacna1s
Hereditary PancreatitisCasp9
Hereditary Paraganglioma-Pheochromocytoma SyndromesSdha , Sdhb , Sdhc , Sdhd
hereditary renal cell carcinomaSdha
hereditary spastic paraplegia 30Ndufa10
hereditary spastic paraplegia 53Lpl
hereditary spastic paraplegia 75Cox6b1 , Psenen
hereditary spastic paraplegia 76Capn1
heroin dependenceFas , Grin2a
herpes simplexApoe
Herpes Simplex EncephalitisApoe
herpes simplex virus keratitisApoe , Il1b , Tnf
herpes zosterTnf
hidradenitis suppurativaTnf
high grade gliomaBad , Capn1 , Cox8a , Fas , Mapk3 , Plcb3 , Tnf
High-Frequency Hearing LossTnf
HIV EncephalitisApp , Bace1 , Cdk5
HIV SeropositivityAph1b
HIV Wasting SyndromeIl1b , Tnf
Hodgkin's lymphomaMapk1
holoprosencephalyCyc1
homocystinuriaNdufv3
human immunodeficiency virus infectious diseaseFas , Tnf
Human InfluenzaIl1b , Nos1 , Tnf , Tnfrsf1a
Huntington's diseaseCasp3 , Casp8 , Casp9 , Cycs , Fas , Gapdh , Grin2a , Grin2b , Itpr1 , Plcb3 , Ppp3ca
Huntington's Disease-Like SyndromePsen2
hydronephrosisIl1b
Hydrops FetalisRyr3
HyperalgesiaBace1 , Capn2 , Grin1 , Grin2a , Grin2b , Il1b , Itpr1 , Mapk1 , Mapk3 , Nos1 , Tnf , Tnfrsf1a
HyperapobetalipoproteinemiaLpl
hypercalcemiaTnf
HypercholesterolemiaApoe , Casp3 , Casp9 , Il1b , Lpl
HyperemiaIl1b
hyperglycemiaCasp8 , Il1b
hyperhomocysteinemiaApoe , Grin2a , Grin2b , Il1b , Tnf
hyperinsulinismTnf
hyperkalemic periodic paralysisErn1
Hyperlipemia with Familial Hypercholesterolemic XanthomatosisApoe
Hyperlipoproteinemia Type IIApoe , Lpl
hyperlipoproteinemia type IIIApoe
Hypermetabolism due to Defect in MitochondriaAtp5f1b
HYPERMETABOLISM DUE TO UNCOUPLED MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION 2Atp5f1b
HyperoxiaFadd , Fas , Tnf , Tnfrsf1a
Hyperphosphatemic Familial Tumoral Calcinosis 1Cacna1c , Gapdh , Ndufa9 , Tnfrsf1a
hypersplenismFas
hypertensionApoe , App , Atp2a3 , Atp5f1a , Bad , Cacna1c , Casp3 , Casp8 , Casp9 , Cox5b , Fadd , Gsk3b , Il1b , Lpl , Mme , Nos1 , Tnf
HypertriglyceridemiaApoe , Lpl , Ndufb6
hypertrophic cardiomyopathyAph1b , Cacna1c , Capn2 , Casp3 , Ndufs1 , Ndufs2 , Uqcrc1
hypertrophic cardiomyopathy 1Cacna1c
hypertrophic pyloric stenosisNos1
HypertrophyMapk1 , Mapk3
hyperuricemiaApoe
HypoalbuminemiaA2m
hypochromic microcytic anemiaTnf
Hypoglossal Nerve InjuriesMme
hypoglycemiaCacna1c , Grin2b , Il1b , Tnf
hypokalemic periodic paralysisCacna1s
Hypokalemic Periodic Paralysis, Type 1Cacna1s
hypolipoproteinemiaIl1b
hypoparathyroidism-deafness-renal disease syndromeAtp5f1c , Calml3 , Calml5
hypoplastic left heart syndromeCapn2
HypotensionGrin2b , Il1b , Tnf
HypothermiaFas , Tnf
hypothyroidismApoe , Atp2a2 , Atp5po , Bad , Cdk5r1
HypoxiaAtp5f1a , Atp5f1b , Casp3 , Gapdh , Grin2b , Itpr1 , Mme , Nos1
idiopathic generalized epilepsyNdufb10 , Ube2i
idiopathic pulmonary fibrosisFas , Sdha , Tnf
IgA glomerulonephritisAdam10 , Fas , Il1b , Tnf , Tnfrsf1a
immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndromeCacna1f , Ndufb11
immunodeficiency 17Bace1
immunodeficiency 18Bace1
immunodeficiency 19Bace1
immunodeficiency 42Aph1a
immunodeficiency 51Bid
impotenceBad , Casp3 , Nos1 , Tnf
inclusion body myopathy with Paget disease of bone and frontotemporal dementiaTnf
inclusion body myositisFas
infantile histiocytoid cardiomyopathyNdufb11
Infantile Hypertrophic Pyloric Stenosis 1Nos1
infectious mononucleosisFas
InflammationA2m , Cdk5 , Il1b , Tnf
inflammatory bowel diseaseTnf
inflammatory bowel disease 28Bace1
inherited metabolic disorderNdufs1 , Ndufs2 , Uqcrb
Insulin ResistanceBad , Casp3 , Casp8 , Fas , Il1b , Lpl , Mapk3 , Tnf , Tnfrsf1a
intellectual disabilityAtp5f1a , Bace1 , Bad , Cacna1c , Cacna1d , Capn1 , Casp12 , Cox8a , Fadd , Grin1 , Grin2a , Grin2b , Grin2d , Itpr1 , Itpr2 , Mapk1 , Mapt , Ndufa10 , Ndufa6 , Ndufc2 , Ndufs3 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2 , Plcb3 , Ppp3r2 , Psen1 , Sdhd
intermediate uveitisTnf
intermittent claudicationBad , Casp3
interstitial cystitisTnf
Intervertebral Disc DisplacementTnf
Intestinal Carcinoid TumorsSdhd
intestinal diseaseCasp3
Intestinal NeoplasmsGsk3b
intestinal perforationNos1
Intestinal Reperfusion InjuryAtp5f1d , Casp3 , Casp9 , Tnf
Intimal HyperplasiaMapk1
intracranial aneurysmNos1 , Tnf
Intracranial HemorrhagesPsen1 , Tnf
intrahepatic cholangiocarcinomaFas
intrahepatic cholestasis of pregnancyTnf
Intraventricular HemorrhageBace1
invasive ductal carcinomaCacna1c
Invasive Pulmonary AspergillosisIl1b
iron deficiency anemiaApp , Tnf
Iron OverloadAtp2a2 , Mapt
ischemiaCycs , Tnfrsf1a
Islet Cell Tumor SyndromeSdhb , Sdhc , Sdhd
isolated anhidrosis with normal sweat glandsItpr2
isolated microphthalmia 5Bace1
Joint InstabilityCacna1c
Joubert syndrome 1Grin1
juvenile rheumatoid arthritisMapk1
Kashin-Beck DiseaseFas
Kawasaki diseaseIl1b , Tnf
Kearns-Sayre syndromeIl1b
keratoconjunctivitis siccaTnf
keratoconusIl1b , Ppp3cc
keratosis follicularisAtp2a2
keratosis pilaris atrophicansLrp1
kidney diseaseCasp3 , Casp8 , Casp9 , Mapk1 , Ppp3ca , Tnf , Tnfrsf1a
kidney failureAdam10 , Apoe , Il1b , Mme
Kidney NeoplasmsMapk1 , Mapk3 , Sdhb
Kidney Reperfusion InjuryAdam17 , Apaf1 , Casp3 , Casp7 , Fas , Il1b , Ndufb8 , Tnf , Tnfrsf1a
Klebsiella InfectionsApoe
Kleefstra syndrome 1Grin1
Klippel-Feil syndrome 1Uqcrb
Klippel-Trenaunay syndromeGnaq
Koolen de Vries syndromeMapt
Kuhnt-Junius degenerationApoe
labyrinthitisTnf
lactic acidosisAtp5f1a , Ndufs4 , Uqcrfs1
Landau-Kleffner syndromeGrin2a , Grin2b
Language Development DisordersCacna1c , Grin1 , Grin2a
late onset Parkinson's diseaseMapt
learning disabilityApp , Il1b , Mapt , Psen1
Leber hereditary optic neuropathyIl1b , Ndufs2
Leber Hereditary Optic Neuropathy, Autosomal Recessive 2Ndufs2
Left Ventricular HypertrophyAdam17 , Atp5f1d , Atp5pf , Mapk1 , Ppp3ca , Ppp3cb , Ppp3r1
Legionnaires' diseaseTnfrsf1a
Leigh diseaseAtp5po , Grin1 , Ndufa10 , Ndufa12 , Ndufa2 , Ndufa9 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs7 , Ndufs8 , Ndufv1 , Sdha , Sdhc
leishmaniasisTnf
leprosyTnf
leptospirosisIl1b
lethal congenital glycogen storage disease of heartCdk5
LethargyIl1b
leukemiaBad , Fadd
leukocyte adhesion deficiency 3Bad , Capn1 , Cox8a , Plcb3
LeukocytosisIl1b
Lewy body dementiaApoe , Snca
limited sclerodermaFas
linear skin defects with multiple congenital anomalies 1Cox7b , Ndufb11
linear skin defects with multiple congenital anomalies 2Cox7b
linear skin defects with multiple congenital anomalies 3Ndufb11
Lipoprotein GlomerulopathyApoe
lissencephaly 7 with cerebellar hypoplasiaCdk5
listeriosisTnf
liver cirrhosisA2m , Casp3 , Casp8 , Casp9 , Il1b , Tnf
liver diseaseFas , Tnf
Liver InjuryAtp5f1a , Atp5f1b , Atp5pf , Fas
Liver NeoplasmsTnf
Liver Reperfusion InjuryAtf6 , Bad , Casp12 , Casp3 , Casp8 , Casp9 , Eif2ak3 , Fadd , Fas , Gsk3b , Il1b , Tnf , Tnfrsf1a
localized sclerodermaTnf
long QT syndromeCacna1c , Cacna1s , Calm2 , Calm3 , Cdk5 , Plcb4
long QT syndrome 1Cacna1c , Calm2 , Calm3
long QT syndrome 14Calm1
long QT syndrome 15Calm2
long QT syndrome 16Calm3
long QT syndrome 8Cacna1c
low tension glaucomaApoe , Tnf
lung adenocarcinomaAtp5pd , Fas , Gapdh , Hsd17b10 , Ppp3ca
lung cancerCasp8 , Fas
lung carcinomaApoe
lung diseaseA2m , Il1b , Tnf
Lung InjuryMme , Tnf , Tnfrsf1a
Lung NeoplasmsA2m , Apoe , Calml3 , Casp7 , Casp8 , Fas , Il1b , Mapk1 , Mapk3 , Tnf
lung non-small cell carcinomaApaf1 , Bad , Casp3 , Casp7 , Casp8 , Casp9 , Cycs , Gnaq , Il1b , Sdha , Sdhc , Tnf , Tnfrsf1a
Lung Reperfusion InjuryCasp3 , Il1b , Tnf
lung squamous cell carcinomaCycs
lupus nephritisFas , Il1b , Tnf , Tnfrsf1a
Lyme NeuroborreliosisIl1b
lymphangioleiomyomatosisGapdh
Lymphatic MetastasisCasp9 , Cycs , Fas
Lymphomatoid PapulosisFas
lymphopeniaIl1b , Tnf
lymphoproliferative syndromeFas
lymphoproliferative syndrome 2Gapdh , Ndufa9 , Tnfrsf1a
Lynch syndromeCalm2 , Cox7a2l
MacrocephalyGrin1
macular degenerationApoe , Atf6 , Bad , Cacna1f , Fas
major depressive disorderCacna1c , Calm2 , Nos1
malariaApoe , Tnf
male infertilityFas
Malignant FeverCacna1s
malignant hyperthermiaCacna1s
Manganese PoisoningIl1b , Snca , Tnf
mantle cell lymphomaGsk3b
megacolonA2m , Ndufs1 , Tnf
melanomaCapn1 , Casp8 , Fas , Gnaq , Grin2a , Mapk1 , Plcb4 , Sdhd , Tnf
MELAS syndromeIl1b , Ndufs1
membranoproliferative glomerulonephritisIl1b
membranous glomerulonephritisA2m , Apoe , Il1b , Mme
Memory DisordersApoe , App , Cacna1d , Il1b , Mapk1 , Mapk3 , Mapt , Nos1 , Psen1
Meningeal TuberculosisTnf
Menkes diseaseCox7b , Eif2ak3
Mercury PoisoningApoe
MERRF SyndromeIl1b
Metabolic Brain DiseasesFas
Metabolic Brain Diseases, InbornNdufs4
metabolic dysfunction-associated steatohepatitisIl1b , Tnf
metabolic dysfunction-associated steatotic liver diseaseApoe , Atp5f1a , Atp5f1b , Fas , Ide , Il1b , Lpl , Tnf
Metabolic SyndromeFadd , Fas , Tnf , Tnfrsf1a
methylmalonic acidemiaCycs
mevalonic aciduriaTnf
MHC class II deficiencyAph1a , Grin2a
microcephalyGrin2a , Sdhd
Microcephaly, Epilepsy, and Diabetes SyndromeAtp5f1a
Micronuclei, Chromosome-DefectiveTnf
middle cerebral artery infarctionApaf1 , Apoe , App , Bad , Casp3 , Casp9 , Cdk5 , Fadd , Gapdh , Grin1 , Gsk3b , Il1b , Mapk1 , Mapk3 , Mapt , Nae1 , Tnf , Tnfrsf1a
Middle East respiratory syndromeIl1b , Tnf
migraineLrp1 , Tnf
migraine without auraLrp1 , Tnf
mitochondrial complex I deficiencyNdufa1 , Ndufa10 , Ndufa11 , Ndufa2 , Ndufb10 , Ndufb11 , Ndufb3 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2
mitochondrial complex II deficiencySdha , Sdhb , Sdhd
Mitochondrial Complex II Deficiency Nuclear Type 1Sdha , Sdhb , Sdhd
Mitochondrial Complex II Deficiency Nuclear Type 3Sdhd
Mitochondrial Complex II Deficiency Nuclear Type 4Sdhb
mitochondrial complex III deficiency nuclear type 1Cyc1 , Uqcrb , Uqcrc2 , Uqcrq
Mitochondrial Complex III Deficiency Nuclear Type 10Uqcrfs1
Mitochondrial Complex III Deficiency Nuclear Type 11Uqcrh
mitochondrial complex III deficiency nuclear type 3Uqcrb
mitochondrial complex III deficiency nuclear type 4Uqcrq
mitochondrial complex III deficiency nuclear type 5Uqcrc2
mitochondrial complex III deficiency nuclear type 6Cyc1
mitochondrial complex IV deficiency nuclear type 1Cox6b1
mitochondrial complex IV deficiency nuclear type 15Cox8a
mitochondrial complex IV deficiency nuclear type 16Cox4i1
mitochondrial complex IV deficiency nuclear type 18Cox6a2
mitochondrial complex IV deficiency nuclear type 20Cox5a
mitochondrial complex IV deficiency nuclear type 21Ndufa4
mitochondrial complex IV deficiency nuclear type 7Cox6b1
mitochondrial complex V (ATP synthase) deficiency nuclear type 3Atp5f1d , Atp5f1e
mitochondrial complex V (ATP synthase) deficiency nuclear type 4Atp5f1a
mitochondrial complex V (ATP synthase) deficiency nuclear type 4AAtp5f1a
mitochondrial complex V (ATP synthase) deficiency nuclear type 4BAtp5f1a
mitochondrial complex V (ATP synthase) deficiency nuclear type 5Atp5f1d
mitochondrial complex V (ATP synthase) deficiency nuclear type 7Atp5po
mitochondrial encephalomyopathyNdufs2 , Ndufv2
mitochondrial metabolism diseaseAtp5f1a , Atp5f1d , Casp8 , Ndufa6 , Ndufb7 , Ndufc2 , Uqcrfs1
mitochondrial myopathyIl1b , Tnf
mixed connective tissue diseaseFas , Tnf
MLS syndromeNdufb11
Moebius syndromePlcb2
Monomelic AmyotrophyRyr3
morphine dependenceFadd , Grin2a , Mapk1 , Mapk3 , Nos1
motor neuron diseaseNos1
Mouth NeoplasmsGapdh
movement diseaseItpr1
Moyamoya diseaseFas
mucocutaneous leishmaniasisTnf
mucolipidosis type IVNdufa7
mucopolysaccharidosis VITnf
mucositisIl1b
mucosulfatidosisItpr1
Multi-Infarct DementiaApp
Multiple AbnormalitiesGsk3b
multiple endocrine neoplasia type 2ASdha
multiple intestinal atresiaCalm2
multiple myelomaApoe , Il1b , Tnf
Multiple Organ FailureIl1b , Mapk1 , Tnf
multiple sclerosisA2m , Apoe , Ern1 , Fas , Il1b , Ndufs2 , Tnf , Tnfrsf1a
multiple system atrophyFas , Mapt , Snca
Multiple System Atrophy (MSA) with Orthostatic HypotensionMapt
Multisystemic Smooth Muscle Dysfunction SyndromeFas
Muscle WeaknessTnfrsf1a
muscular atrophyApaf1 , Cacna1s , Gsk3b , Tnf
muscular diseaseIl1b , Lpl , Sdha
muscular dystrophyTnf
myasthenia gravisFas
Mycobacterium avium complex diseaseTnf
Mycoplasma InfectionsCasp3
Mycoplasma pneumoniae pneumoniaTnf
myelodysplastic syndromeFas , Il1b , Plcb1 , Tnf
myeloid leukemiaSnca
myocardial infarctionApoe , Atp5f1d , Atp5po , Casp3 , Gsk3b , Il1b , Lpl , Lrp1 , Mapk1 , Ndufb5 , Plcb1 , Plcb3 , Tnf , Tnfrsf1a
Myocardial IschemiaApoe , Cox5b , Eif2ak3 , Il1b , Ppp3r1 , Tnf , Uqcrfs1
Myocardial Reperfusion InjuryAtp2a1 , Atp2a2 , Atp5f1d , Bad , Bid , Casp12 , Casp3 , Casp7 , Casp8 , Casp9 , Fadd , Fas , Gapdh , Gsk3b , Il1b , Mapk1 , Mapk3 , Ndufs1 , Tnf
myocardial stunningAtp2a2 , Tnf
myocarditisTnf
myopathySdha
myopiaCacna1f
myositisTnf
Nasal PolypsFas , Tnf , Tnfrsf1a
nasal type extranodal NK/T-cell lymphomaFas
nasopharynx carcinomaGrin2a
NauseaTnf
NecrosisApp , Fas , Gapdh , Il1b , Lpl , Tnf
nemaline myopathy 6Aph1b
Nematode InfectionsTnfrsf1a
NeointimaAtp2a2
neonatal abstinence syndromeGrin2a
Neonatal Inflammatory Skin and Bowel Disease 1Adam17
Neoplasm InvasivenessIl1b , Mapk1 , Mapk3 , Tnf
Neoplasm MetastasisApoe , Calml3 , Casp3 , Fadd , Fas , Mapk1 , Mapk3 , Tnf
Neoplasm MicrometastasisCycs
Neoplastic Cell TransformationGsk3b
nephritisCasp8 , Fas
nephronophthisis 15Bace1
nephrosisIl1b
nephrotic syndromeA2m , Apoe , Il1b , Nos1
nephrotoxicityCacna1s , Itpr1
Nerve DegenerationApoe , App , Casp3 , Cdk5r1 , Grin2d , Mapk1 , Mapk3 , Nos1 , Psen1 , Snca , Tnf
nervous system diseaseCasp3 , Casp9 , Nos1 , Tnf
Nervous System MalformationsPsen1
Nervous System TraumaGrin2b , Nos1
Neu-Laxova syndrome 2Gnaq
neural tube defectApaf1
NeuralgiaCdk5 , Grin2a , Nos1 , Tnf
neurilemmomaSnca
Neurobehavioral ManifestationsApoe , Nos1 , Snca
neuroblastomaIl1b , Sdhc , Tnf
Neurodegeneration with Ataxia and Late-Onset Optic AtrophySdha
neurodegeneration with brain iron accumulation 5Cacna1f , Ndufb11
neurodegenerative diseaseApp , Itpr1 , Mapt , Psen1 , Snca
neurodevelopmental disorder with dysmorphic facies and distal limb anomaliesCacna1c
NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND ISCHIOPUBIC HYPOPLASIANae1
neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizuresCacna1c
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIESGrin2a
Neurodevelopmental Disorder with or without Hyperkinetic Movements and Seizures, Autosomal RecessiveGrin1
Neurodevelopmental DisordersApp , Atp5mc2 , Atp5pf , Bace2 , Bid , Cacna1c , Casp8 , Cox7c , Grin1 , Grin2a , Grin2b , Itpr1 , Mapk3 , Ndufa2 , Ndufb11 , Ndufb3 , Ndufs1 , Ndufs4 , Uqcrq
Neurogenic InflammationApp , Tnf , Tnfrsf1a
neuronal ceroid lipofuscinosisApbb1 , Atp2a1
neuronal ceroid lipofuscinosis 6AGsk3b , Mapk1 , Mapk3
neuropathyCox6a1 , Mme
neutropeniaIl1b , Tnf
Neutropenic EnterocolitisIl1b
nicotine dependenceGrin2b
Niemann-Pick disease type AApbb1 , Itpr1
Niemann-Pick disease type BApbb1
Nijmegen breakage syndromeSdhb
non-syndromic X-linked intellectual disability 1Hsd17b10
nonphotosensitive trichothiodystrophy 5Ndufa1
Noonan syndromeApaf1
Noonan syndrome 13Mapk1
NSAID-EnteropathyCasp9
nuclear type mitochondrial complex I deficiency 1Ndufa10 , Ndufa11 , Ndufa2 , Ndufb11 , Ndufs1 , Ndufs2 , Ndufs3 , Ndufs4 , Ndufs7 , Ndufs8 , Ndufv1 , Ndufv2
nuclear type mitochondrial complex I deficiency 12Ndufa1
nuclear type mitochondrial complex I deficiency 13Ndufa2
nuclear type mitochondrial complex I deficiency 14Ndufa11
nuclear type mitochondrial complex I deficiency 2Ndufs8
nuclear type mitochondrial complex I deficiency 22Ndufa10
nuclear type mitochondrial complex I deficiency 23Ndufa12
nuclear type mitochondrial complex I deficiency 24Ndufb9
nuclear type mitochondrial complex I deficiency 25Ndufb3
nuclear type mitochondrial complex I deficiency 26Ndufa9
nuclear type mitochondrial complex I deficiency 3Ndufs7
nuclear type mitochondrial complex I deficiency 30Ndufb11
nuclear type mitochondrial complex I deficiency 32Ndufb8
nuclear type mitochondrial complex I deficiency 33Ndufa6
nuclear type mitochondrial complex I deficiency 35Ndufb10
Nuclear Type Mitochondrial Complex I Deficiency 36Ndufc2
Nuclear Type Mitochondrial Complex I Deficiency 37Ndufa8
Nuclear Type Mitochondrial Complex I Deficiency 39Ndufb7
nuclear type mitochondrial complex I deficiency 4Ndufv1
nuclear type mitochondrial complex I deficiency 5Ndufs1
nuclear type mitochondrial complex I deficiency 6Ndufs2
nuclear type mitochondrial complex I deficiency 7Ndufv2
nuclear type mitochondrial complex I deficiency 8Ndufs3
obesityApoe , App , Atp5f1b , Atp5f1c , Atp5f1d , Atp5mc2 , Bad , Cox7c , Cox8b , Cycs , Fadd , Gapdh , Il1b , Lpl , Mapk1 , Mapk3 , Mapt , Ndufb6 , Nos1 , Tnf , Tnfrsf1a , Uqcrc2
obstructive lung diseaseA2m
obstructive sleep apneaIl1b , Tnf , Tnfrsf1a
occupational asthmaTnf
ocular hypertensionFas
oculoauricular syndromeFadd
omphaloceleLrp1
open-angle glaucomaApoe , Tnf
opioid abuseGrin1 , Grin2a , Grin2b
Opsoclonus-Myoclonus SyndromeSdha
optic atrophyNdufs3
Optic Nerve InjuriesTnfrsf1a
optic neuritisCapn1
oral squamous cell carcinomaGapdh , Gsk3b , Il1b , Tnf
oral submucous fibrosisTnf
oropharynx cancerErn1
osteoarthritisBad , Casp3 , Casp9 , Gapdh , Il1b , Ndufs8 , Ndufv1 , Sdha
Osteoarthritis, ExperimentalCasp3 , Casp7 , Casp8 , Mapk3
Osteoarthritis, HipMapt
OsteolysisTnf
osteopetrosisNdufs8
osteoporosisGapdh , Il1b
osteosarcomaHsd17b10
otitis mediaA2m , Il1b , Tnf
Otitis Media with EffusionA2m , Il1b , Tnf
ovarian cancerFas , Sdhb , Sdhc , Tnf , Tnfrsf1a , Ube2i
ovarian carcinomaPpp3ca
Ovarian NeoplasmsGsk3b , Mapk1 , Mapk3
Oxygen-Induced RetinopathyCasp3 , Fas , Il1b , Tnf
PainGrin1 , Plcb1 , Tnf , Tnfrsf1a
Painful NeuropathyTnf
pancreatic adenocarcinomaMapk1
pancreatic cancerApaf1 , Apoe , Bad , Bid , Casp8 , Casp9 , Cycs , Il1b , Tnf
Pancreatic CystIl1b
pancreatic ductal carcinomaMapk3
pancreatitisCasp12 , Casp3 , Il1b , Lpl , Ppp3ca
pantothenate kinase-associated neurodegenerationSnca
PAPA syndromeIl1b
papillomavirus infectious diseaseCasp8
paracoccidioidomycosisIl1b , Tnf
paragangliomaSdha , Sdhb , Sdhc , Sdhd
Paragangliomas 1Sdhd
Paragangliomas 3Sdhb , Sdhc , Sdhd
Paragangliomas 4Sdhb , Sdhd
Paragangliomas 5Sdha
Paragangliomas with Sensorineural Hearing LossSdhd
ParalysisApp
paraplegiaHsd17b10
parathyroid carcinomaAph1a , Atf6 , Cacna1s , Capn2 , Ncstn , Ndufs2 , Psen2 , Sdhc
Parkinson's diseaseA2m , Apaf1 , Apoe , Casp3 , Casp9 , Fas , Gsk3b , Il1b , Mapk1 , Mapk3 , Mapt , Ndufb8 , Ndufs1 , Ndufs4 , Ndufv2 , Nos1 , Sdha , Snca , Tnf
Parkinson's disease 1Snca
Parkinson's disease 20Atp5po
Parkinson's disease 4Snca
Parkinson's Disease, MitochondrialNdufv2
ParkinsonismApaf1 , Bad , Casp3 , Casp9 , Gapdh , Il1b , Mapt , Ndufs3 , Nos1 , Snca , Tnf
PARKINSONISM WITH POLYNEUROPATHYUqcrc1
Pediatric Crohn's DiseaseTnf
Penetrating WoundsTnf
peptic esophagitisTnf
peptic ulcer diseaseIl1b
perinatal necrotizing enterocolitisIl1b , Tnf
periodontitisApp , Il1b , Mme , Tnf
Peripheral Nerve InjuriesApoe , Capn2 , Il1b , Tnf
peripheral nervous system diseaseCasp9 , Cox6a1 , Mme
peripheral vascular diseaseFas
Peritoneal AdhesionsSdha
Peritoneal FibrosisErn1
peritonitisA2m , Gsk3b , Tnf
periventricular leukomalaciaTnf
peroxisome biogenesis disorder 12ANcstn
peroxisome biogenesis disorder 2BGapdh , Tnfrsf1a
persistent fetal circulation syndromeCox4i1
phencyclidine abuseCalm1 , Calm2
phenylketonuriaGrin2b
pheochromocytomaHsd17b10 , Sdha , Sdhb , Sdhc , Sdhd
PhotophobiaAtf6
Pick's diseaseMapt , Psen1 , Snca
Picornaviridae InfectionsTnf
pilocytic astrocytomaSdha
placenta diseaseTnf
placental insufficiencyGrin1 , Grin2a , Grin2b
plagueIl1b
Plaque, AtheroscleroticApoe , Tnf
plasmacytomaTnf
Plasmodium falciparum malariaFas , Tnf
pleomorphic xanthoastrocytomaCycs , Ndufa5 , Ndufb2 , Ube2d2b
Pleural EffusionTnf
pleural tuberculosisIl1b
pleurisyIl1b , Tnf
pleuropulmonary blastomaCox8c
Pneumococcal MeningitisAdam17 , Tnf
Pneumococcal PneumoniaMapk1 , Mapk3 , Tnf
pneumoniaIl1b , Tnf , Tnfrsf1a
PoisoningGsk3b
Polyarteritis Nodosa, Childhood-OnsetBid
polycystic ovary syndromeAtp5f1b
polymyositisIl1b , Tnf , Tnfrsf1a
polyneuropathyIl1b
Port-Wine StainGnaq
portal hypertensionIl1b , Mapk1 , Nos1 , Tnf
post-traumatic stress disorderCacna1c , Casp12 , Casp9 , Grin2a
Postmenopausal OsteoporosisIl1b , Tnf
Postoperative Cognitive DysfunctionIl1b , Mapk1 , Mapk3 , Tnf
pre-eclampsiaFas , Itpr1 , Itpr2 , Itpr3 , Ryr3 , Tnf
pre-malignant neoplasmAtp5f1b , Bid , Casp3 , Casp8 , Casp9 , Fas
Pregnancy Complications, InfectiousApoe
Pregnancy in DiabeticsGapdh
Pregnancy-Induced HypertensionTnf
PrehypertensionNos1
Premature AgingApp , Mapt
Premature BirthTnf
Prenatal Exposure Delayed EffectsAdam10 , Nos1
PresbycusisCacna1d
Presenile and Senile DementiaApoe , App , Il1b , Psen2
Primary Aldosteronism, Seizures, and Neurologic AbnormalitiesCacna1d
Primary Autosomal Recessive Microcephaly 21Gapdh
primary biliary cholangitisFas , Tnf , Tnfrsf1a
primary ciliary dyskinesiaNdufb6 , Ndufv3
primary coenzyme Q10 deficiency 7Grin1
primary cutaneous amyloidosisApoe
primary cutaneous T-cell non-Hodgkin lymphomaFas
Primary Graft DysfunctionTnf
primary hyperaldosteronismCacna1d
primary hyperoxaluria type 1Ndufa10
primary immunodeficiency diseaseCacna1c , Casp8 , Fas
Primary Lymphedema with MyelodysplasiaNdufb4
primary open angle glaucomaApoe , Tnf
primary ovarian insufficiencyRyr3
primary pulmonary hypertensionNdufs1
Primary Pulmonary Hypertension, 1Casp8 , Ndufb3
primary sclerosing cholangitisTnf
Progressive Microcephaly with Seizures and Cerebral and Cerebellar AtrophyUqcrc1
progressive myoclonus epilepsyNdufv3
progressive supranuclear palsyEif2ak3 , Mapt
Progressive Supranuclear Palsy AtypicalMapt
propionic acidemiaUqcrfs1
prostate adenocarcinomaMapk1
prostate cancerCacna1d , Casp3 , Fas , Grin1 , Lrp1 , Mapt , Plcb4 , Tnf
prostate carcinomaBad
prostate carcinoma in situLrp1
prostatic hypertrophyBad , Fadd
Prostatic NeoplasmsBad , Casp3 , Casp9 , Fas , Gsk3b , Itpr1 , Lpl , Mapk3 , Mme , Ppp3ca
proteasome-associated autoinflammatory syndrome 1Itpr3 , Tnf
protein-energy malnutritionCox4i1
proteinuriaApoe , Fas
Pseudomonas Aeruginosa KeratitisIl1b
Pseudomonas InfectionsIl1b , Tnf , Tnfrsf1a
psoriasisApoe , Il1b , Tnf , Tnfrsf1a
psoriatic arthritisTnf
Psychomotor AgitationCacna1c , Mapt
psychotic disorderGrin1
PTEN hamartoma tumor syndromeSdhb
Pulmonary Arterial HypertensionCasp8 , Ndufb3
Pulmonary AtresiaSdha
pulmonary edemaIl1b , Tnf
pulmonary emphysemaTnf
pulmonary fibrosisBad , Il1b , Psen2 , Tnf
Pulmonary HemorrhagePsen2
pulmonary hypertensionAtp2a2 , Atp5f1a , Atp5pf , Il1b , Mapk1 , Mapk3 , Ryr3 , Tnf
pulmonary sarcoidosisTnf
pulmonary tuberculosisIl1b , Tnf
pulmonary valve stenosisCacna1c
pulmonary venoocclusive diseaseEif2ak3
Puromycin Aminonucleoside NephrosisApoe , Fas
pustulosis of palm and soleTnf
pyridoxine-dependent epilepsyGrin2a
Pyruvate Dehydrogenase E2 DeficiencySdhd
Radiation PneumonitisTnf , Tnfrsf1a
radiculopathyTnf
Rafiq syndromeGrin1
RASopathyBace1 , Ndufb2
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsCapn1 , Fadd , Ndufs8 , Ndufv1
Refractory AnemiaTnf
relapsing polychondritisTnf
relapsing-remitting multiple sclerosisApoe , Fas
renal cell carcinomaApaf1 , Atp5mc2 , Bad , Casp3 , Fas , Mapk1 , Sdhb , Sdhd , Tnf , Tnfrsf1a
Renal Cell Carcinoma 1Sdhb
renal coloboma syndromeNdufb8
renal fibrosisAdam17 , Lrp1 , Mapk1 , Tnfrsf1a
renal hypertensionTnf
Renal IschemiaApaf1
renovascular hypertensionNos1
Reperfusion InjuryApaf1 , Bad , Bid , Casp12 , Casp3 , Casp8 , Casp9 , Eif2ak3 , Fas , Grin2a , Grin2b , Il1b , Nos1 , Ppp3ca , Ppp3cb , Tnf , Tnfrsf1a
respiratory allergyIl1b , Tnf
respiratory failureCacna1s , Mapt
respiratory syncytial virus infectious diseaseTnf
respiratory system diseaseTnf
Respiratory Tract InfectionsTnf
restrictive cardiomyopathyCacna1c
reticulate acropigmentation of KitamuraAdam10
Retina Reperfusion InjuryApaf1 , Bad , Casp7 , Il1b , Tnf
retinal artery occlusionTnf
retinal detachmentApaf1 , Casp3 , Casp8 , Casp9 , Fas , Tnf , Tnfrsf1a
retinal diseaseApoe , Casp3 , Tnf
Retinal NeovascularizationLrp1
retinal vein occlusionIl1b
retinitisIl1b
retinitis pigmentosaAtf6 , Cacna1f , Casp7 , Grin2b
retinoblastomaFas
retinopathy of prematurityIl1b , Nos1
RhabdomyolysisCacna1s
rhabdomyosarcomaSdha , Sdhc
rheumatic heart diseaseGapdh
rheumatoid arthritisA2m , Casp7 , Fas , Il1b , Tnf , Tnfrsf1a
rhinitisIl1b , Tnf
RhinosinusitisIl1b , Tnf
Right Ventricular HypertrophyNos1 , Ppp3ca , Ppp3cb , Tnf
RNASET2-deficient cystic leukoencephalopathyNdufa2
Romano-Ward SyndromeCacna1c
root resorptionTnf , Tnfrsf1a
salivary gland diseaseCasp3
SAPHO syndromeTnf
sarcomaTnf
SarcopeniaAtp5f1a
schizophreniaApoe , Atp2a1 , Atp5f1c , Bace1 , Cacna1c , Calml3 , Calml5 , Cox5a , Grin1 , Grin2a , Grin2b , Grin2d , Gsk3b , Il1b , Lrp1 , Mapk3 , Ncstn , Ndufa10 , Ndufv2 , Nos1 , Plcb1 , Ppp3ca , Ppp3cb , Ppp3cc , Ppp3r1 , Snca , Tnf , Uqcrc2
sciatic neuropathyApoe , Cacna1d , Capn1 , Capn2 , Casp12 , Casp3 , Casp7 , Casp8 , Fas , Grin1 , Grin2b , Gsk3b , Il1b , Lrp1 , Tnf , Tnfrsf1a
scleritisTnf
scrapieAtf6 , Casp3 , Casp9
sea-blue histiocytosisApoe
secondary Parkinson diseaseSnca
seminomaFas
sensorineural hearing lossApoe , Fadd , Tnf
sensory peripheral neuropathyBace1
SepsisA2m , Atp2a1 , Bad , Cacna1s , Casp3 , Casp8 , Casp9 , Fas , Grin2a , Gsk3b , Il1b , Mapk1 , Mapk3 , Ndufb8 , Nos1 , Tnf
septic arthritisTnf
severe acute respiratory syndromeCasp3 , Casp9 , Il1b , Mapk1 , Mapk3 , Tnf
severe congenital neutropenia 3Aph1a
severe congenital neutropenia 5Aph1a
Sezary's diseaseMapk1
shigellosisIl1b
ShockMapk1 , Mapk3 , Tnf
short QT syndromeCacna1c
short-rib thoracic dysplasia 9 with or without polydactylyNdufb10 , Ube2i
Shy-Drager SyndromeMapt
sick sinus syndromeCacna1d
sickle cell anemiaTnf
silicosisIl1b , Tnf , Tnfrsf1a
Sinoatrial Node Dysfunction and DeafnessCacna1d
sinusitisIl1b
Sjogren's syndromeApoe , Fas , Tnf
Skin AbnormalitiesApaf1
skin diseaseIl1b , Ndufb8 , Tnf
Skin NeoplasmsCasp8
sleep apneaApoe
Sleep DeprivationBace1 , Grin2b
sleep disorderIl1b
small cell carcinomaTnf
Small-For-Size SyndromeBad , Il1b
Soft Tissue NeoplasmsTnf
spastic ataxiaItpr1
Spastic Ataxia 9, Autosomal RecessiveChp1
speech disorderGrin2a
spermatic cord torsionCasp3
Spinal Cord CompressionFas , Tnf , Tnfrsf1a
spinal cord diseaseApp
Spinal Cord InjuriesApaf1 , Apoe , Atp2a1 , Atp2a2 , Capn1 , Casp12 , Casp3 , Casp9 , Fadd , Fas , Gapdh , Il1b , Lrp1 , Mapt , Nos1 , Tnf , Tnfrsf1a
Spinal Cord Reperfusion InjuryBad , Cdk5 , Cdk5r1 , Gapdh
Spine OsteoarthritisTnf
spinocerebellar ataxia type 15Itpr1
spinocerebellar ataxia type 17Atp5f1b
spinocerebellar ataxia type 29Itpr1
Spinocerebellar AtaxiasCapn1 , Casp7 , Itpr1 , Mme
SplenomegalyApoe , App , Fas , Mapt , Psen1
split hand-foot malformation 5Atp5mc3
spondyloarthropathyTnf
spondylocostal dysostosis 5Mapk3
spondylometaphyseal dysplasia with corneal dystrophyPlcb3
Spontaneous AbortionsApoe , Il1b
Sporadic Creutzfeldt-Jakob DiseaseMapt
squamous cell carcinomaFas , Gapdh , Mapk1 , Mapk3 , Tnfrsf1a
ST Elevation Myocardial InfarctionAtp5mc2
Stable AnginaTnf
Staphylococcal PneumoniaIl1b
status asthmaticusIl1b
status epilepticusAdam10 , Atp2a2 , Casp3 , Casp8 , Eif2ak3 , Grin1 , Grin2a , Gsk3b , Il1b , Nos1 , Tnf
steatotic liver diseaseApoe , Atf6 , Cycs , Eif2ak3 , Ern1 , Il1b , Tnf
Stevens-Johnson syndromeTnf
stomach cancerCasp3 , Casp9 , Il1b
Stomach NeoplasmsBid , Casp8 , Il1b , Mapk1 , Mapk3 , Ndufa2 , Ndufs1 , Ndufv1 , Tnf
Stomatognathic DiseasesFadd
Streptococcal InfectionsTnf
Streptococcus pneumoniaTnf
StrokeApoe , Casp3 , Il1b , Ndufc2 , Nos1 , Tnf
Sturge-Weber syndromeGnaq
Subacute Necrotizing Encephalopathy of Leigh, InfantileAtp5po , Ndufa10 , Ndufa12 , Ndufs1 , Ndufs3 , Ndufs4 , Ndufs7 , Ndufs8 , Ndufv1 , Sdha
Subarachnoid HemorrhageApoe , Casp3 , Casp9 , Ern1 , Gsk3b , Il1b , Tnf
substance-induced psychosisSnca
substance-related disorderGsk3b
Sudden Cardiac DeathCacna1c
Sudden DeathCacna1c
Sudden Hearing LossTnf
sudden infant death syndromeCalm2
Sudden Unexpected Nocturnal Death SyndromeCacna1c
suppurative otitis mediaA2m
Supraventricular TachycardiaCacna1d
syndromic intellectual disabilityMapt
syndromic microphthalmia 3Ndufb5
syndromic microphthalmia 5Adam17
syndromic X-linked intellectual disability 14Ndufa1
syndromic X-linked intellectual disability Cabezas typeNdufa1
syndromic X-linked intellectual disability Lubs typeCacna1f , Cox7b , Hsd17b10 , Ndufa1 , Ndufb11
syndromic X-linked intellectual disability type 10Hsd17b10
synucleinopathySnca
Systemic CandidiasisTnf
Systemic Inflammatory Response SyndromeIl1b
systemic lupus erythematosusFas , Il1b , Tnf , Tnfrsf1a
systemic sclerodermaIl1b
TachycardiaGsk3b , Tnf
Taste DisordersFas
tauopathyCdk5 , Gsk3b , Mapt
temporal lobe epilepsyGrin2b , Mapt , Nos1
Temporomandibular Joint DisordersTnf
Temporomandibular Joint OsteoarthritisAtf6 , Casp12 , Eif2ak3 , Ern1 , Fas
Temtamy syndromeGapdh , Tnfrsf1a
testicular diseasePpp3ca
Testicular InjuryFas
Testis Reperfusion InjuryApaf1 , Casp3 , Casp9 , Mapk1 , Mapk3
thalassemiaIl1b , Tnf
thoracic aortic aneurysmAdam10 , Adam17 , Fas
thrombocytopeniaCycs , Il1b , Plcb2 , Tnf
Thrombocytopenia 4Cycs
thrombocytosisIl1b
thrombosisTnf
thyroid cancerMapk1
Thyroid NeoplasmsIl1b , Mapk1 , Tnf
Thyrotoxic Periodic ParalysisCacna1s
Timothy syndromeCacna1c
TinnitusGrin2a , Tnf
Tobacco Use DisorderApbb1
Tongue NeoplasmsTnf
toxic encephalopathyCasp3
toxic shock syndromeA2m , Il1b , Tnf
trachomaTnf
transient cerebral ischemiaApoe , Atp5f1b , Bace1 , Bad , Casp3 , Casp7 , Casp8 , Casp9 , Cdk5 , Cycs , Fadd , Fas , Grin2a , Grin2b , Il1b , Itpr1 , Nos1 , Tnf , Tnfrsf1a
transitional cell carcinomaApaf1 , Casp3 , Fas , Mapk1 , Tnf
Transplant RejectionErn1 , Il1b , Tnf
traumatic brain injuryAdam10 , App , Bad , Capn1 , Capn2 , Casp3 , Il1b , Mapt , Ncstn , Ppp3r1 , Ppp3r2 , Psen1 , Tnf
TremorCacna1c
trichinosisTnf
trichodontoosseous syndromeAtp5mc1
trichorhinophalangeal syndrome type INdufb9
tricuspid atresiaLrp1
trigeminal neuralgiaCdk5 , Cdk5r1 , Grin1 , Il1b , Mapk1 , Mapk3 , Tnf
trypanosomiasisA2m
tuberculosisTnf
tuberous sclerosis 1Grin1
tuberous sclerosis 2Ndufb10 , Ube2i
type 1 diabetes mellitusApoe , Casp12 , Casp3 , Casp8 , Casp9 , Eif2ak3 , Fas , Il1b , Itpr3 , Nos1 , Tnf
type 2 diabetes mellitusAdam17 , Apoe , Atp2a1 , Atp2a2 , Atp2a3 , Atp5f1b , Bace2 , Bad , Cacna1d , Calm1 , Casp12 , Casp3 , Casp7 , Casp8 , Casp9 , Fas , Gapdh , Gsk3b , Ide , Il1b , Lpl , Mapk1 , Mapk3 , Nos1 , Sdhb , Tnf , Tnfrsf1a
typhoid feverTnf
ulcerative colitisCasp3 , Fas , Il1b , Tnf
ureteral obstructionAdam10 , Adam17 , Casp12 , Casp3 , Casp7 , Casp9 , Il1b , Mapk1 , Mapk3 , Tnf , Tnfrsf1a
urethral obstructionMapk1 , Nos1
urinary bladder cancerAtp5f1d , Atp5mc2 , Casp3 , Casp9 , Fas , Gsk3b , Il1b , Ncstn , Ppp3cc , Tnf , Ube2i
Urinary IncontinenceMapk1
urinary tract infectionIl1b
Urination DisordersNos1
urticariaIl1b , Tnf
Uterine Cervical NeoplasmsCasp8 , Mapk1
uveal melanomaGnaq , Plcb4
uveitisIl1b , Tnf , Tnfrsf1a
varicoceleCasp9 , Fas , Il1b
vascular dementiaApp , Atp5f1a , Cdk5 , Grin1 , Grin2a , Grin2b , Gsk3b , Il1b , Mapk1 , Mapt , Psen2 , Snca , Tnf
vascular diseaseTnf
Vascular System InjuriesApoe , Tnf
velocardiofacial syndromeMapk1
Venous ThromboembolismTnf
Venous ThrombosisApoe , Il1b
Ventilator-Induced Lung InjuryIl1b
Ventricular DysfunctionTnf
Ventricular Dysfunction, LeftApoe , Atp2a2 , Fas
Ventricular Fibrillation, Paroxysmal Familial, 1Cacna1c
Ventricular RemodelingCasp3 , Nos1
Ventricular TachycardiaAtp2a2 , Cacna1c , Ppp3ca
Vici syndromeAtp5f1a
Viral BronchiolitisFas , Gapdh , Tnf
Viral MyocarditisCasp3 , Casp8
viral pneumoniaIl1b , Tnf