MAPK3 (mitogen-activated protein kinase 3) - Rat Genome Database

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Gene: MAPK3 (mitogen-activated protein kinase 3) Sus scrofa
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Symbol: MAPK3
Name: mitogen-activated protein kinase 3
RGD ID: 13887126
Description: ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase activity (ortholog); protein kinase activity (ortholog); INVOLVED IN aging (ortholog); animal organ morphogenesis (ortholog); arachidonic acid metabolic process (ortholog); PARTICIPATES IN ceramide signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH 16p11.2 Deletion Syndrome (ortholog); Aberrant Crypt Foci (ortholog); Alzheimer's disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH (S)-nicotine; 3,3',4,4',5-pentachlorobiphenyl; 3,3',4,4'-tetrachlorobiphenyl
Type: protein-coding
RefSeq Status: MODEL
Also known as: ERK1; extracellular signal-regulated kinase-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,291,445 - 18,299,567 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,291,444 - 18,299,410 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
16p11.2 Deletion Syndrome  (ISO)
Aberrant Crypt Foci  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
Atrophy  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
brain ischemia  (ISO)
cardiomyopathy  (ISO)
Cocaine-Related Disorders  (ISO)
colon adenocarcinoma  (ISO)
colorectal adenocarcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Coronavirus infectious disease  (ISO)
coronin-1A deficiency  (ISO)
Developmental Disabilities  (ISO)
Diabetic Cardiomyopathies  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
episodic kinesigenic dyskinesia 1  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
Female Infertility  (ISO)
gastric ulcer  (ISO)
Gliosis  (ISO)
Glycogen Storage Disease XII  (ISO)
Head and Neck Neoplasms  (ISO)
high grade glioma  (ISO)
Hyperalgesia  (ISO)
Hypertrophy  (ISO)
Insulin Resistance  (ISO)
Kidney Neoplasms  (ISO)
Lung Neoplasms  (ISO)
Mammary Neoplasms, Experimental  (ISO)
middle cerebral artery infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
Neurodevelopmental Disorders  (ISO)
neuronal ceroid lipofuscinosis 6  (ISO)
obesity  (ISO)
Osteoarthritis, Experimental  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic ductal carcinoma  (ISO)
Pneumococcal Pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries, Experimental  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Shock  (ISO)
Spondylocostal Dysostosis 5  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Testis Reperfusion Injury  (ISO)
trigeminal neuralgia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
animal organ morphogenesis  (ISO)
arachidonic acid metabolic process  (ISO)
Bergmann glial cell differentiation  (IEA,ISO)
BMP signaling pathway  (IEA)
cardiac neural crest cell development involved in heart development  (IEA,ISO)
cartilage development  (IEA,ISO)
caveolin-mediated endocytosis  (IEA)
cell surface receptor signaling pathway  (IBA)
cellular response to amino acid starvation  (IEA)
cellular response to cadmium ion  (IEA)
cellular response to DNA damage stimulus  (ISO)
cellular response to dopamine  (IEA)
cellular response to mechanical stimulus  (IEA)
cellular response to reactive oxygen species  (IEA)
cellular response to tumor necrosis factor  (IEA,ISO)
decidualization  (ISO)
DNA damage induced protein phosphorylation  (IEA)
ERK1 and ERK2 cascade  (IEA,ISO)
face development  (IEA,ISO)
interleukin-1-mediated signaling pathway  (IEA)
intracellular signal transduction  (IBA,ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
MAPK cascade  (IEA,ISO)
negative regulation of apolipoprotein binding  (IEA)
neural crest cell development  (ISO)
outer ear morphogenesis  (IEA,ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-tyrosine autophosphorylation  (IEA)
phosphorylation  (ISO)
positive regulation of cellular protein metabolic process  (IEA)
positive regulation of cyclase activity  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of histone acetylation  (IEA)
positive regulation of histone phosphorylation  (IEA)
positive regulation of macrophage chemotaxis  (IEA,ISO)
positive regulation of macrophage proliferation  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of telomerase activity  (IEA)
positive regulation of telomere capping  (IEA)
positive regulation of telomere maintenance via telomerase  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of translation  (ISO)
positive regulation of xenophagy  (IEA,ISO)
protein phosphorylation  (IEA,ISO)
protein-containing complex assembly  (ISO)
regulation of cellular pH  (IEA,ISO)
regulation of cytoskeleton organization  (IEA)
regulation of DNA-binding transcription factor activity  (IEA)
regulation of early endosome to late endosome transport  (IEA)
regulation of Golgi inheritance  (IEA)
regulation of ossification  (IEA,ISO)
regulation of stress-activated MAPK cascade  (IEA)
response to epidermal growth factor  (IEA)
response to exogenous dsRNA  (IEA,ISO)
response to lipopolysaccharide  (ISO)
response to toxic substance  (ISO)
sensory perception of pain  (IEA)
stress-activated MAPK cascade  (IEA)
thymus development  (IEA,ISO)
thyroid gland development  (IEA,ISO)
trachea formation  (IEA,ISO)
transcription, DNA-templated  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:12943991   PMID:16310170   PMID:18694803   PMID:19038864   PMID:19215954   PMID:19570883   PMID:19786114   PMID:19955189   PMID:20300568   PMID:21215800   PMID:21483702   PMID:22279582  
PMID:22915817   PMID:23403092   PMID:24096891   PMID:24520418   PMID:25473050   PMID:26115165   PMID:26721325   PMID:27618100  


Genomics

Comparative Map Data
MAPK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,291,445 - 18,299,567 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,291,444 - 18,299,410 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAPK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1630,114,105 - 30,123,506 (-)EnsemblGRCh38hg38GRCh38
GRCh381630,114,105 - 30,123,309 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371630,125,426 - 30,134,541 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,032,927 - 30,042,131 (-)NCBINCBI36hg18NCBI36
Build 341630,032,927 - 30,042,039NCBI
Celera1672,661,419 - 72,670,625 (+)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1627,786,557 - 27,795,763 (-)NCBIHuRef
CHM1_11631,341,181 - 31,350,385 (-)NCBICHM1_1
Mapk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,358,798 - 126,364,988 (+)NCBIGRCm39mm39
GRCm39 Ensembl7126,358,773 - 126,364,991 (+)Ensembl
GRCm387126,759,626 - 126,765,816 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,759,601 - 126,765,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv377133,903,140 - 133,909,330 (+)NCBIGRCm37mm9NCBIm37
MGSCv367126,550,780 - 126,556,964 (+)NCBImm8
Celera7126,607,166 - 126,613,154 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.25NCBI
Mapk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21181,366,646 - 181,372,863 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1181,366,637 - 181,372,863 (+)Ensembl
Rnor_6.01198,192,773 - 198,198,975 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,192,773 - 198,198,975 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,172,641 - 205,178,843 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,935,044 - 185,941,245 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,084,924 - 186,091,127 (+)NCBI
Celera1179,022,318 - 179,028,386 (+)NCBICelera
Cytogenetic Map1q36NCBI
Mapk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,869,668 - 6,879,152 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,870,699 - 6,876,836 (+)NCBIChiLan1.0ChiLan1.0
MAPK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11630,489,362 - 30,498,026 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1630,489,362 - 30,498,017 (-)Ensemblpanpan1.1panPan2
MAPK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,109,184 - 18,115,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,109,222 - 18,114,425 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,687,831 - 19,694,273 (-)NCBI
ROS_Cfam_1.0618,245,190 - 18,251,639 (-)NCBI
UMICH_Zoey_3.1618,044,145 - 18,050,587 (-)NCBI
UNSW_CanFamBas_1.0617,959,533 - 17,965,981 (-)NCBI
UU_Cfam_GSD_1.0618,275,160 - 18,281,602 (-)NCBI
Mapk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,287,605 - 124,292,797 (+)NCBI
SpeTri2.0NW_00493650112,342,670 - 12,390,650 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,536,471 - 26,545,666 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl526,536,532 - 26,546,461 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660682,993,354 - 3,002,555 (-)NCBIVero_WHO_p1.0
Mapk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478213,150,824 - 13,158,327 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 1 14 1 2
Low 2 4 3 4 2 9 2 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000053446   ⟹   ENSSSCP00000044198
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl318,291,450 - 18,299,402 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000060796   ⟹   ENSSSCP00000057520
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl318,291,445 - 18,299,567 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000079208   ⟹   ENSSSCP00000062461
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl318,291,445 - 18,299,401 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000083095   ⟹   ENSSSCP00000065068
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl318,291,447 - 18,299,418 (-)Ensembl
RefSeq Acc Id: XM_021088019   ⟹   XP_020943678
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1318,291,444 - 18,299,410 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020943678 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ADK92149 (Get FASTA)   NCBI Sequence Viewer  
  JAA74217 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020943678   ⟸   XM_021088019
- Sequence:
RefSeq Acc Id: ENSSSCP00000065068   ⟸   ENSSSCT00000083095
RefSeq Acc Id: ENSSSCP00000057520   ⟸   ENSSSCT00000060796
RefSeq Acc Id: ENSSSCP00000062461   ⟸   ENSSSCT00000079208
RefSeq Acc Id: ENSSSCP00000044198   ⟸   ENSSSCT00000053446
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000040682 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000044198 UniProtKB/TrEMBL
  ENSSSCP00000057520 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000062461 UniProtKB/TrEMBL
  ENSSSCP00000065068 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000053446 UniProtKB/TrEMBL
  ENSSSCT00000060796 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000079208 UniProtKB/TrEMBL
  ENSSSCT00000083095 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  MAPK_ERK1/2 UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene MAPK3 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PRINTS ERK1ERK2MAPK UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287AJK9_PIG UniProtKB/TrEMBL
  A0A287BLM6_PIG UniProtKB/TrEMBL
  A0A5G2QCY4_PIG UniProtKB/TrEMBL
  A0A5G2QKL2_PIG UniProtKB/TrEMBL
  M3V839_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90003 ENTREZGENE