RGD Reference Report - The ERK signaling cascade--views from different subcellular compartments. - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

The ERK signaling cascade--views from different subcellular compartments.

Authors: Yao, Z  Seger, R 
Citation: Yao Z and Seger R, Biofactors. 2009 Sep-Oct;35(5):407-16. doi: 10.1002/biof.52.
RGD ID: 8553538
Pubmed: (View Article at PubMed) PMID:19565474
DOI: Full-text: DOI:10.1002/biof.52

The extracellular signal-regulated kinase cascade is a central signaling pathway that is stimulated by various extracellular stimuli. The signals of these stimuli are then transferred by the cascade's components to a large number of targets at distinct subcellular compartments, which in turn induce and regulate a large number of cellular processes. To achieve these functions, the cascade exhibits versatile and dynamic subcellular distribution that allows proper temporal and spatial modulation of the appropriate processes. In this review, we discuss the intracellular localizations of different components of the ERK cascade, and the impact of these localizations on their activation and specificity.

Gene Ontology Annotations    

Cellular Component

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Map2k1  (mitogen activated protein kinase kinase 1)
Map2k2  (mitogen activated protein kinase kinase 2)
Mapk1  (mitogen activated protein kinase 1)
Mapk3  (mitogen activated protein kinase 3)

Additional Information