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Gene: Mapk1 (mitogen activated protein kinase 1) Rattus norvegicus
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Symbol: Mapk1
Name: mitogen activated protein kinase 1
Description: Exhibits several functions, including ATP binding activity; MAP kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including decidualization; positive regulation of gene expression; and protein phosphorylation. Localizes to several cellular components, including the caveola; dendrite cytoplasm; and perikaryon. Used to study coronary artery disease (multiple); gastric ulcer; middle cerebral artery infarction; type 2 diabetes mellitus; and ureteral obstruction. Biomarker of renal fibrosis and urethral obstruction. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; adenosine signaling pathway; Bone morphogenetic proteins signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-catechin; (+)-dihydromyricetin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ERK-2; Erk2; ERT1; extracellular signal-regulated kinase 2; extracellular-signal-regulated kinase 1; extracellular-signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAPK 1; MAPK 2; mitogen-activated protein kinase 1; mitogen-activated protein kinase 2; p42-MAPK
Orthologs:
Homo sapiens (human) : MAPK1 (mitogen-activated protein kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Mapk1 (mitogen-activated protein kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mapk1 (mitogen-activated protein kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MAPK1 (mitogen-activated protein kinase 1)
Canis lupus familiaris (dog) : MAPK1 (mitogen-activated protein kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mapk1 (mitogen-activated protein kinase 1)
Sus scrofa (pig) : MAPK1 (mitogen-activated protein kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01188,203,863 - 88,273,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,211,599 - 88,273,254 (-)Ensembl
Rnor_5.01191,260,412 - 91,325,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,968,732 - 86,030,387 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,009,328 - 86,070,984 (-)NCBI
Celera1182,713,470 - 82,779,260 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model