Mapk1 (mitogen activated protein kinase 1) - Rat Genome Database

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Gene: Mapk1 (mitogen activated protein kinase 1) Rattus norvegicus
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Symbol: Mapk1
Name: mitogen activated protein kinase 1
RGD ID: 70500
Description: Exhibits several functions, including ATP binding activity; MAP kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including ERK1 and ERK2 cascade; decidualization; and positive regulation of macromolecule biosynthetic process. Localizes to several cellular components, including caveola; dendrite cytoplasm; and perikaryon. Used to study coronary artery disease (multiple); gastric ulcer; middle cerebral artery infarction; type 2 diabetes mellitus; and ureteral obstruction. Biomarker of renal fibrosis and urethral obstruction. Human ortholog(s) of this gene implicated in Noonan syndrome 13; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; adenosine signaling pathway; Bone morphogenetic proteins signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-catechin; (+)-dihydromyricetin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ERK-2; Erk2; ERT1; extracellular signal-regulated kinase 2; extracellular-signal-regulated kinase 1; extracellular-signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAPK 1; MAPK 2; mitogen-activated protein kinase 1; mitogen-activated protein kinase 2; p42-MAPK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21183,957,813 - 84,023,629 (-)NCBI
Rnor_6.0 Ensembl1188,211,599 - 88,273,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01188,203,863 - 88,273,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01191,260,412 - 91,325,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,968,732 - 86,030,387 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,009,328 - 86,070,984 (-)NCBI
Celera1182,713,470 - 82,779,260 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model