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Gene: Ep300 (E1A binding protein p300) Rattus norvegicus
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Symbol: Ep300
Name: E1A binding protein p300
Description: Exhibits several functions, including DNA binding activity; DNA-binding transcription factor binding activity; and p53 binding activity. Involved in several processes, including cellular response to organic cyclic compound; positive regulation of cell development; and regulation of protein metabolic process. Localizes to several cellular components, including chromatin; nucleus; and protein-DNA complex. Used to study diabetic retinopathy and membranoproliferative glomerulonephritis. Biomarker of congenital diaphragmatic hernia; heart disease; hepatocellular carcinoma; hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Orthologous to human EP300 (E1A binding protein p300); PARTICIPATES IN androgen signaling pathway; cortisol signaling pathway; estrogen signaling pathway; INTERACTS WITH 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 11-deoxycorticosterone; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: MODEL
Also known as: histone acetyltransferase p300
Orthologs:
Homo sapiens (human) : EP300 (E1A binding protein p300)  HGNC  Alliance
Mus musculus (house mouse) : Ep300 (E1A binding protein p300)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ep300 (E1A binding protein p300)
Pan paniscus (bonobo/pygmy chimpanzee) : EP300 (E1A binding protein p300)
Canis lupus familiaris (dog) : ZC3H7B (zinc finger CCCH-type containing 7B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ep300 (E1A binding protein p300)
Sus scrofa (pig) : EP300 (E1A binding protein p300)
Chlorocebus sabaeus (African green monkey) : EP300 (E1A binding protein p300)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07122,818,194 - 122,889,055 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,818,975 - 122,861,296 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07122,792,742 - 122,863,551 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47119,938,507 - 120,008,886 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17119,972,736 - 120,000,026 (+)NCBI
Celera7109,426,729 - 109,497,522 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ep300
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620036
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.