1-(5-isoquinolinesulfonyl)-2-methylpiperazine multiple interactions EXP 6480464 [1-5-Isoquinolinesulfonyl-2-Methylpiperazine co-treated with Doxorubicin] results in increased expression of EP300 protein CTD PMID:15767673 1-(5-isoquinolinesulfonyl)-2-methylpiperazine increases expression EXP 6480464 1-5-Isoquinolinesulfonyl-2-Methylpiperazine results in increased expression of EP300 protein CTD PMID:15767673 11-deoxycorticosterone multiple interactions EXP 6480464 Desoxycorticosterone promotes the reaction [EP300 protein binds to SULT1A1 promoter], Desoxycorticosterone promotes the reaction [EP300 protein binds to TAT promoter] CTD PMID:22465009 17beta-estradiol multiple interactions ISO RGD:1348463 6480464 Estradiol inhibits the reaction [EP300 protein binds to COMT promoter] more ... CTD PMID:16489025 more ... 17beta-estradiol decreases expression ISO RGD:1348463 6480464 Estradiol results in decreased expression of EP300 mRNA CTD PMID:30684530 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactions ISO RGD:1348463 6480464 [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to EP300 protein modified form] CTD PMID:28751236 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO RGD:1348463 6480464 Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]] more ... CTD PMID:18487222 more ... 2,3,4,7,8-Pentachlorodibenzofuran multiple interactions ISO RGD:1348463 6480464 2 more ... CTD PMID:21703235 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1552027 6480464 Tetrachlorodibenzodioxin affects the expression of EP300 mRNA CTD PMID:21570461 , PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1348463 6480464 EP300 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] more ... CTD PMID:16489025 more ... 2,3,7,8-Tetrachlorodibenzofuran multiple interactions ISO RGD:1348463 6480464 2 more ... CTD PMID:21703235 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of EP300 mRNA CTD PMID:21346803 2-hydroxypropanoic acid increases expression ISO RGD:1348463 6480464 Lactic Acid results in increased expression of EP300 mRNA CTD PMID:30851411 3-aminobenzamide multiple interactions EXP 6480464 3-aminobenzamide inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA] CTD PMID:22228707 5-(2-chloroethyl)-4-methylthiazole multiple interactions ISO RGD:1552027 6480464 Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of EP300 protein] CTD PMID:24892905 5-(2-methylpiperazine-1-sulfonyl)isoquinoline multiple interactions EXP 6480464 [1-5-Isoquinolinesulfonyl-2-Methylpiperazine co-treated with Doxorubicin] results in increased expression of EP300 protein CTD PMID:15767673 5-(2-methylpiperazine-1-sulfonyl)isoquinoline increases expression EXP 6480464 1-5-Isoquinolinesulfonyl-2-Methylpiperazine results in increased expression of EP300 protein CTD PMID:15767673 5-aza-2'-deoxycytidine affects methylation ISO RGD:1348463 6480464 Decitabine affects the methylation of EP300 promoter CTD PMID:17965222 5-aza-2'-deoxycytidine decreases expression ISO RGD:1552027 6480464 Decitabine results in decreased expression of EP300 mRNA CTD PMID:27915011 5-aza-2'-deoxycytidine multiple interactions ISO RGD:1348463 6480464 Decitabine promotes the reaction [EP300 protein binds to TP53 protein] CTD PMID:17977830 5-fluorouracil multiple interactions ISO RGD:1348463 6480464 Fluorouracil promotes the reaction [EP300 protein binds to UBE2C promoter] CTD PMID:27129209 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole multiple interactions ISO RGD:1348463 6480464 Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter], Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter] CTD PMID:21703235 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions ISO RGD:1552027 6480464 6-chloro-2 more ... CTD PMID:25665036 8-Br-cAMP decreases expression ISO RGD:1348463 6480464 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of EP300 mRNA CTD PMID:22079614 aconitine affects expression ISO RGD:1348463 6480464 Aconitine affects the expression of EP300 protein CTD PMID:32234357 aconitine multiple interactions ISO RGD:1348463 6480464 crenigacestat affects the reaction [Aconitine affects the expression of EP300 protein] CTD PMID:32234357 aldehydo-D-glucose multiple interactions ISO RGD:1348463 6480464 [cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein] more ... CTD PMID:22228707 , PMID:25192544 aldehydo-D-glucose increases expression ISO RGD:1348463 6480464 Glucose results in increased expression of EP300 mRNA CTD PMID:22228707 , PMID:26045780 all-trans-retinoic acid multiple interactions ISO RGD:1552027 6480464 Tretinoin inhibits the reaction [EP300 protein binds to RETN promoter] CTD PMID:15047602 all-trans-retinoic acid increases expression ISO RGD:1348463 6480464 Tretinoin results in increased expression of EP300 mRNA CTD PMID:28053092 all-trans-retinoic acid multiple interactions ISO RGD:1348463 6480464 [GABPA protein binds to EP300 protein] promotes the reaction [Tretinoin results in increased expression of ITGB2 mRNA], EP300 protein promotes the reaction [Tretinoin results in increased expression of ITGB2 mRNA] CTD PMID:16581781 all-trans-retinyl palmitate multiple interactions EXP 6480464 retinol palmitate promotes the reaction [EP300 protein binds to MMP9 protein] CTD PMID:17164434 allethrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of EP300 mRNA CTD PMID:33051911 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of EP300 mRNA CTD PMID:16483693 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of EP300 mRNA CTD PMID:30779732 amphotericin B multiple interactions ISO RGD:1348463 6480464 Amphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:16189267 Anacardic acid decreases expression ISO RGD:1552027 6480464 anacardic acid results in decreased expression of EP300 protein CTD PMID:23297412 Anacardic acid affects activity ISO RGD:1348463 6480464 anacardic acid affects the activity of EP300 protein CTD PMID:18349320 Anacardic acid multiple interactions EXP 6480464 anacardic acid inhibits the reaction [Phenylephrine results in increased expression of EP300 protein] CTD PMID:23297412 apigenin multiple interactions ISO RGD:1348463 6480464 Apigenin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 apocynin multiple interactions ISO RGD:1348463 6480464 acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] CTD PMID:19281832 arsenous acid increases expression ISO RGD:1348463 6480464 Arsenic Trioxide results in increased expression of EP300 mRNA CTD PMID:20458559 arsenous acid multiple interactions ISO RGD:1348463 6480464 Arsenic Trioxide promotes the reaction [EP300 protein binds to and results in increased acetylation of TP73 protein] CTD PMID:15031205 arsenous acid increases activity ISO RGD:1348463 6480464 Arsenic Trioxide results in increased activity of EP300 protein CTD PMID:15031205 berberine increases expression ISO RGD:1348463 6480464 Berberine results in increased expression of EP300 mRNA CTD PMID:27311644 bis(2-chloroethyl) sulfide decreases expression ISO RGD:1552027 6480464 Mustard Gas results in decreased expression of EP300 mRNA CTD PMID:18955075 bisphenol A multiple interactions ISO RGD:1348463 6480464 [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to EP300 protein modified form] more ... CTD PMID:24533973 more ... bisphenol A affects methylation ISO RGD:1552027 6480464 bisphenol A affects the methylation of EP300 promoter CTD PMID:27334623 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of EP300 mRNA CTD PMID:25181051 butanal decreases expression ISO RGD:1348463 6480464 butyraldehyde results in decreased expression of EP300 mRNA CTD PMID:26079696 butyric acid increases expression ISO RGD:1348463 6480464 Butyric Acid results in increased expression of EP300 mRNA CTD PMID:23524101 cadmium atom multiple interactions ISO RGD:1552027 6480464 Cadmium promotes the reaction [MTF1 protein binds to EP300 protein] CTD PMID:18458062 calcitriol affects localization ISO RGD:1552027 6480464 Calcitriol affects the localization of EP300 protein CTD PMID:15647825 calcitriol multiple interactions ISO RGD:1552027 6480464 Calcitriol promotes the reaction [EP300 protein binds to CYP24A1 promoter], Calcitriol promotes the reaction [EP300 protein binds to SPP1 promoter] CTD PMID:15647825 camptothecin decreases expression ISO RGD:1348463 6480464 Camptothecin results in decreased expression of EP300 mRNA, Camptothecin results in decreased expression of EP300 protein CTD PMID:10344722 carbon nanotube decreases expression ISO RGD:1552027 6480464 Nanotubes, Carbon results in decreased expression of EP300 mRNA CTD PMID:25554681 casticin decreases expression ISO RGD:1348463 6480464 casticin results in decreased expression of EP300 mRNA CTD PMID:27862857 chromium atom increases activity ISO RGD:1552027 6480464 Chromium results in increased activity of EP300 protein CTD PMID:21467744 chromium(6+) multiple interactions ISO RGD:1552027 6480464 chromium hexavalent ion inhibits the reaction [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]], EP300 protein inhibits the reaction [chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1 mRNA]] CTD PMID:18605988 , PMID:21467744 cilostazol affects expression ISO RGD:1552027 6480464 cilostazol affects the expression of EP300 protein CTD PMID:24254769 cilostazol multiple interactions ISO RGD:1552027 6480464 E-3-2 more ... CTD PMID:24254769 cisplatin multiple interactions ISO RGD:1348463 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of EP300 mRNA more ... CTD PMID:20856196 , PMID:27392435 cisplatin increases expression ISO RGD:1552027 6480464 Cisplatin results in increased expression of EP300 protein CTD PMID:21310163 cisplatin multiple interactions ISO RGD:1552027 6480464 [PIWIL2 protein co-treated with Cisplatin] results in decreased expression of EP300 protein CTD PMID:21310163 cisplatin decreases expression ISO RGD:1348463 6480464 Cisplatin results in decreased expression of EP300 protein CTD PMID:17498666 clobetasol decreases expression ISO RGD:1552027 6480464 Clobetasol results in decreased expression of EP300 mRNA CTD PMID:27462272 cobalt dichloride multiple interactions ISO RGD:1348463 6480464 [cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein], scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:25192544 copper atom multiple interactions EXP 6480464 [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein], [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein CTD PMID:22276220 copper atom multiple interactions ISO RGD:1348463 6480464 [Chelating Agents binds to Copper] which results in increased expression of EP300 mRNA CTD PMID:30911355 copper(0) multiple interactions EXP 6480464 [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein], [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein CTD PMID:22276220 copper(0) multiple interactions ISO RGD:1348463 6480464 [Chelating Agents binds to Copper] which results in increased expression of EP300 mRNA CTD PMID:30911355 copper(II) sulfate increases expression ISO RGD:1348463 6480464 Copper Sulfate results in increased expression of EP300 mRNA CTD PMID:19549813 crocidolite asbestos decreases expression ISO RGD:1552027 6480464 Asbestos, Crocidolite results in decreased expression of EP300 mRNA CTD PMID:29279043 curcumin multiple interactions ISO RGD:1348463 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein] more ... CTD PMID:17927689 , PMID:22258452 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]] more ... CTD PMID:22228707 , PMID:26612707 curcumin decreases activity EXP 6480464 Curcumin results in decreased activity of EP300 protein CTD PMID:26612707 curcumin decreases expression ISO RGD:1348463 6480464 Curcumin results in decreased expression of EP300 mRNA, Curcumin results in decreased expression of EP300 protein CTD PMID:17927689 curcumin affects localization ISO RGD:1348463 6480464 Curcumin affects the localization of EP300 protein CTD PMID:17927689 cyhalothrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of EP300 mRNA CTD PMID:33051911 cypermethrin multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of EP300 mRNA CTD PMID:33051911 cyproconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of EP300 mRNA CTD PMID:29038839 cyproterone acetate multiple interactions ISO RGD:1348463 6480464 [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to EP300 protein modified form] CTD PMID:28751236 D-glucose multiple interactions ISO RGD:1348463 6480464 [cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein] more ... CTD PMID:22228707 , PMID:25192544 D-glucose increases expression ISO RGD:1348463 6480464 Glucose results in increased expression of EP300 mRNA CTD PMID:22228707 , PMID:26045780 deoxynivalenol multiple interactions ISO RGD:1348463 6480464 EP300 protein affects the reaction [deoxynivalenol results in increased expression of ATF3 protein alternative form] CTD PMID:30286430 deoxynivalenol increases expression ISO RGD:1348463 6480464 deoxynivalenol results in increased expression of EP300 protein CTD PMID:30286430 dexamethasone multiple interactions EXP 6480464 Dexamethasone promotes the reaction [EP300 protein binds to SULT1A1 promoter] more ... CTD PMID:17884810 more ... dexamethasone multiple interactions ISO RGD:1552027 6480464 Dexamethasone promotes the reaction [EP300 protein binds to FOXO3 gene] CTD PMID:26758684 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of EP300 mRNA CTD PMID:32494933 dexamethasone multiple interactions ISO RGD:1348463 6480464 [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form] more ... CTD PMID:18188457 dextran sulfate multiple interactions ISO RGD:1552027 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of EP300 mRNA CTD PMID:29950665 diarsenic trioxide increases expression ISO RGD:1348463 6480464 Arsenic Trioxide results in increased expression of EP300 mRNA CTD PMID:20458559 diarsenic trioxide multiple interactions ISO RGD:1348463 6480464 Arsenic Trioxide promotes the reaction [EP300 protein binds to and results in increased acetylation of TP73 protein] CTD PMID:15031205 diarsenic trioxide increases activity ISO RGD:1348463 6480464 Arsenic Trioxide results in increased activity of EP300 protein CTD PMID:15031205 dibenziodolium multiple interactions ISO RGD:1348463 6480464 diphenyleneiodonium inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] CTD PMID:19281832 dicrotophos increases expression ISO RGD:1348463 6480464 dicrotophos results in increased expression of EP300 mRNA CTD PMID:28302478 diethylstilbestrol decreases expression ISO RGD:1552027 6480464 Diethylstilbestrol results in decreased expression of EP300 protein CTD PMID:15019724 diethylstilbestrol multiple interactions ISO RGD:1348463 6480464 Diethylstilbestrol promotes the reaction [EP300 protein binds to EZH2 promoter] more ... CTD PMID:24533973 , PMID:25088689 dinophysistoxin 1 affects expression ISO RGD:1348463 6480464 dinophysistoxin 1 affects the expression of EP300 mRNA CTD PMID:28939011 dioxygen multiple interactions ISO RGD:1348463 6480464 Amphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] more ... CTD PMID:16189267 , PMID:20153296 disodium selenite decreases expression ISO RGD:1348463 6480464 Sodium Selenite results in decreased expression of EP300 mRNA, Sodium Selenite results in decreased expression of EP300 protein CTD PMID:10344722 doxorubicin multiple interactions EXP 6480464 4-4-fluorophenyl-2-4-hydroxyphenyl-5-4-pyridylimidazole inhibits the reaction [Doxorubicin results in decreased expression of EP300 protein] more ... CTD PMID:11073966 , PMID:15767673 doxorubicin increases expression ISO RGD:1552027 6480464 Doxorubicin results in increased expression of EP300 protein CTD PMID:25665036 doxorubicin multiple interactions ISO RGD:1552027 6480464 6-chloro-2 more ... CTD PMID:25665036 doxorubicin multiple interactions ISO RGD:1348463 6480464 [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] more ... CTD PMID:19047049 doxorubicin decreases expression ISO RGD:1348463 6480464 Doxorubicin results in decreased expression of EP300 mRNA, Doxorubicin results in decreased expression of EP300 protein CTD PMID:10344722 , PMID:17498666 doxorubicin increases degradation EXP 6480464 Doxorubicin results in increased degradation of EP300 protein CTD PMID:11073966 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of EP300 mRNA, Doxorubicin results in decreased expression of EP300 protein CTD PMID:11073966 more ... doxorubicin decreases response to substance ISO RGD:1552027 6480464 EP300 protein results in decreased susceptibility to Doxorubicin CTD PMID:14975762 doxorubicin decreases expression ISO RGD:1552027 6480464 Doxorubicin results in decreased expression of EP300 protein CTD PMID:14975762 ellagic acid increases expression ISO RGD:1348463 6480464 Ellagic Acid results in increased expression of EP300 mRNA CTD PMID:12002526 entinostat multiple interactions ISO RGD:1348463 6480464 entinostat promotes the reaction [EP300 protein binds to RELA protein] CTD PMID:20421217 epoxiconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of EP300 mRNA CTD PMID:29038839 ethanol decreases expression ISO RGD:1552027 6480464 Ethanol results in decreased expression of EP300 protein CTD PMID:24892905 ethanol affects localization EXP 6480464 Ethanol affects the localization of EP300 protein CTD PMID:31887396 ethanol increases expression EXP 6480464 Ethanol results in increased expression of EP300 mRNA CTD PMID:31887396 ethanol multiple interactions ISO RGD:1552027 6480464 Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of EP300 protein] CTD PMID:24892905 etoposide multiple interactions ISO RGD:1348463 6480464 [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein] more ... CTD PMID:19047049 fenvalerate multiple interactions EXP 6480464 [Allethrins co-treated with cyhalothrin co-treated with cypermethrin co-treated with decamethrin co-treated with fenvalerate] affects the expression of EP300 mRNA CTD PMID:33051911 fisetin multiple interactions ISO RGD:1348463 6480464 fisetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 flavone multiple interactions ISO RGD:1348463 6480464 flavone inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 folic acid decreases expression ISO RGD:1552027 6480464 Folic Acid results in decreased expression of EP300 mRNA CTD PMID:25629700 furan decreases expression EXP 6480464 furan results in decreased expression of EP300 mRNA CTD PMID:24614236 galangin multiple interactions ISO RGD:1348463 6480464 galangin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 gallic acid multiple interactions ISO RGD:1348463 6480464 [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein] more ... CTD PMID:27634460 Garcinol multiple interactions ISO RGD:1348463 6480464 garcinol inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] CTD PMID:19281832 genistein multiple interactions ISO RGD:1348463 6480464 EP300 promotes the reaction [Genistein promotes the reaction [trichostatin A results in increased expression of TP53 mRNA]] more ... CTD PMID:26768552 , PMID:30684530 genistein decreases expression ISO RGD:1348463 6480464 Genistein results in decreased expression of EP300 mRNA CTD PMID:30684530 genistein increases expression ISO RGD:1348463 6480464 Genistein results in increased expression of EP300 protein CTD PMID:26768552 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of EP300 mRNA CTD PMID:22061828 glucose multiple interactions ISO RGD:1348463 6480464 [cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein] more ... CTD PMID:22228707 , PMID:25192544 glucose increases expression ISO RGD:1348463 6480464 Glucose results in increased expression of EP300 mRNA CTD PMID:22228707 , PMID:26045780 glyphosate decreases expression ISO RGD:1348463 6480464 glyphosate results in decreased expression of EP300 mRNA CTD PMID:31295307 gold atom multiple interactions ISO RGD:1348463 6480464 [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein] more ... CTD PMID:27634460 , PMID:28433809 gold(0) multiple interactions ISO RGD:1348463 6480464 [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein] more ... CTD PMID:27634460 , PMID:28433809 hyaluronic acid multiple interactions ISO RGD:1348463 6480464 [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] more ... CTD PMID:19047049 irinotecan decreases expression ISO RGD:1348463 6480464 Irinotecan metabolite results in decreased expression of EP300 mRNA, Irinotecan results in decreased expression of EP300 mRNA CTD PMID:15956246 kaempferol multiple interactions ISO RGD:1348463 6480464 kaempferol promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 kojic acid increases expression ISO RGD:1348463 6480464 kojic acid results in increased expression of EP300 mRNA CTD PMID:16595896 KT 5720 multiple interactions ISO RGD:1552027 6480464 KT 5720 inhibits the reaction [cilostazol affects the expression of EP300 protein] CTD PMID:24254769 lead(0) increases expression EXP 6480464 Lead results in increased expression of EP300 mRNA CTD PMID:24291742 lead(2+) increases expression EXP 6480464 Lead results in increased expression of EP300 mRNA CTD PMID:24291742 LY294002 multiple interactions EXP 6480464 2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SIRT6 protein affects the phosphorylation of EP300 protein] CTD PMID:27094368 menadione decreases expression ISO RGD:1348463 6480464 Vitamin K 3 results in decreased expression of EP300 protein CTD PMID:31238027 miconazole decreases expression EXP 6480464 Miconazole results in decreased expression of EP300 mRNA CTD PMID:22262564 miconazole decreases expression ISO RGD:1552027 6480464 Miconazole results in decreased expression of EP300 mRNA CTD PMID:27462272 mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Dexamethasone results in increased expression of EP300 mRNA] CTD PMID:32494933 mono(2-ethylhexyl) phthalate multiple interactions ISO RGD:1348463 6480464 mono-2-ethylhexylphthalate promotes the reaction [PPARA protein binds to EP300 protein] CTD PMID:20123618 myricetin multiple interactions ISO RGD:1348463 6480464 myricetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 N-acetyl-L-cysteine multiple interactions ISO RGD:1348463 6480464 Acetylcysteine inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] CTD PMID:19281832 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1348463 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein] more ... CTD PMID:17927689 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased degradation of EP300 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SIRT6 protein results in decreased expression of EP300 protein] CTD PMID:15767673 , PMID:27094368 niclosamide increases expression ISO RGD:1348463 6480464 Niclosamide results in increased expression of EP300 mRNA CTD PMID:22576131 nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of EP300 mRNA, nitrofen results in decreased expression of EP300 protein CTD PMID:24488106 ochratoxin A decreases expression ISO RGD:1348463 6480464 ochratoxin A results in decreased expression of EP300 mRNA CTD PMID:30763683 okadaic acid decreases expression ISO RGD:1348463 6480464 Okadaic Acid results in decreased expression of EP300 mRNA CTD PMID:28939011 omeprazole multiple interactions ISO RGD:1348463 6480464 Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter], Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter] CTD PMID:21703235 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of EP300 mRNA CTD PMID:25729387 p-menthan-3-ol decreases expression ISO RGD:1348463 6480464 Menthol results in decreased expression of EP300 mRNA CTD PMID:26760959 phenylephrine multiple interactions EXP 6480464 2-2-amino-3-methoxyphenyl-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of EP300 mRNA] more ... CTD PMID:11705990 more ... phenylephrine increases response to substance EXP 6480464 EP300 protein results in increased susceptibility to Phenylephrine CTD PMID:12477714 phenylephrine multiple interactions ISO RGD:1348463 6480464 EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA] CTD PMID:12724418 phenylephrine increases expression EXP 6480464 Phenylephrine results in increased expression of EP300 mRNA, Phenylephrine results in increased expression of EP300 protein CTD PMID:11705990 more ... phlorizin decreases expression ISO RGD:1552027 6480464 Phlorhizin results in decreased expression of EP300 mRNA CTD PMID:22538082 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1348463 6480464 Arsenicals promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [NFE2L2 protein binds to EP300 protein]], Tetradecanoylphorbol Acetate promotes the reaction [NFE2L2 protein binds to EP300 protein] CTD PMID:24632381 pirinixic acid multiple interactions ISO RGD:1552027 6480464 pirinixic acid promotes the reaction [PPARA protein binds to EP300 protein] CTD PMID:20123618 pirinixic acid multiple interactions ISO RGD:1348463 6480464 pirinixic acid promotes the reaction [PPARA protein binds to EP300 protein] CTD PMID:20123618 prochloraz multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of EP300 mRNA CTD PMID:29038839 prostaglandin E2 multiple interactions ISO RGD:1348463 6480464 Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter] more ... CTD PMID:30409902 prostaglandin J2 decreases activity ISO RGD:1348463 6480464 9-deoxy-delta-9-prostaglandin D2 results in decreased activity of EP300 protein CTD PMID:22141352 pyrazinecarboxamide decreases expression EXP 6480464 Pyrazinamide results in decreased expression of EP300 mRNA CTD PMID:22431067 quercetin decreases expression ISO RGD:1348463 6480464 Quercetin results in decreased expression of EP300 protein CTD PMID:15580028 quercetin multiple interactions ISO RGD:1348463 6480464 [trichostatin A co-treated with Quercetin] results in increased expression of EP300 protein more ... CTD PMID:20153296 more ... rac-lactic acid increases expression ISO RGD:1348463 6480464 Lactic Acid results in increased expression of EP300 mRNA CTD PMID:30851411 resveratrol decreases expression ISO RGD:1552027 6480464 resveratrol results in decreased expression of EP300 protein CTD PMID:23297412 resveratrol decreases expression ISO RGD:1348463 6480464 resveratrol results in decreased expression of EP300 mRNA, resveratrol results in decreased expression of EP300 protein CTD PMID:25707573 resveratrol increases expression ISO RGD:1348463 6480464 resveratrol results in increased expression of EP300 mRNA CTD PMID:12002526 , PMID:12569576 resveratrol multiple interactions ISO RGD:1552027 6480464 6-chloro-2 more ... CTD PMID:23297412 , PMID:25665036 resveratrol affects expression ISO RGD:1552027 6480464 resveratrol affects the expression of EP300 protein CTD PMID:24254769 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]], resveratrol inhibits the reaction [Phenylephrine results in increased expression of EP300 protein] CTD PMID:23297412 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of EP300 mRNA, resveratrol results in decreased expression of EP300 protein CTD PMID:23297412 , PMID:25905778 resveratrol multiple interactions ISO RGD:1348463 6480464 2-2-amino-3-methoxyphenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol promotes the reaction [PTGS2 protein binds to EP300 protein]] more ... CTD PMID:16928824 more ... SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [Doxorubicin results in decreased expression of EP300 protein], SB 203580 inhibits the reaction [MAP2K6 protein results in decreased expression of EP300 protein] CTD PMID:15767673 scutellarin multiple interactions ISO RGD:1348463 6480464 scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:25192544 Se-methyl-L-selenocysteine multiple interactions ISO RGD:1348463 6480464 selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter] CTD PMID:25321483 Se-methylselenocysteine multiple interactions ISO RGD:1348463 6480464 selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter] CTD PMID:25321483 silicon dioxide decreases expression ISO RGD:1348463 6480464 Silicon Dioxide results in decreased expression of EP300 mRNA CTD PMID:23623845 sirtinol multiple interactions ISO RGD:1552027 6480464 sirtinol inhibits the reaction [cilostazol affects the expression of EP300 protein], sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]] CTD PMID:24254769 , PMID:25665036 sodium arsenite multiple interactions ISO RGD:1348463 6480464 sodium arsenite inhibits the reaction [EP300 protein binds to IVL promoter] CTD PMID:20006635 sodium arsenite decreases expression ISO RGD:1552027 6480464 sodium arsenite results in decreased expression of EP300 mRNA, sodium arsenite results in decreased expression of EP300 protein CTD PMID:30130555 sodium fluoride decreases expression ISO RGD:1552027 6480464 Sodium Fluoride results in decreased expression of EP300 mRNA CTD PMID:27862939 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of EP300 mRNA CTD PMID:22228707 streptozocin multiple interactions EXP 6480464 3-aminobenzamide inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA], Curcumin inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA] CTD PMID:22228707 sulforaphane multiple interactions ISO RGD:1348463 6480464 sulforaphane inhibits the reaction [EP300 protein binds to COMT promoter] CTD PMID:30684530 sunitinib increases expression ISO RGD:1348463 6480464 Sunitinib results in increased expression of EP300 mRNA CTD PMID:31533062 superoxide decreases abundance ISO RGD:1348463 6480464 EP300 protein results in decreased abundance of Superoxides CTD PMID:25440059 tamoxifen multiple interactions ISO RGD:1348463 6480464 Tamoxifen inhibits the reaction [ESR1 protein binds to EP300 protein] CTD PMID:23665804 tetrathiomolybdate(2-) multiple interactions EXP 6480464 [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein], [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein CTD PMID:22276220 titanium dioxide decreases expression ISO RGD:1552027 6480464 titanium dioxide results in decreased expression of EP300 mRNA CTD PMID:29264374 titanium dioxide multiple interactions ISO RGD:1552027 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of EP300 mRNA CTD PMID:29950665 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of EP300 mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of EP300 mRNA CTD PMID:25729387 trichostatin A affects localization ISO RGD:1348463 6480464 trichostatin A affects the localization of EP300 protein CTD PMID:15647279 trichostatin A affects expression ISO RGD:1348463 6480464 trichostatin A affects the expression of EP300 mRNA CTD PMID:28542535 trichostatin A increases response to substance EXP 6480464 EP300 protein results in increased susceptibility to trichostatin A CTD PMID:12477714 trichostatin A multiple interactions ISO RGD:1348463 6480464 [trichostatin A co-treated with Quercetin] results in increased expression of EP300 protein more ... CTD PMID:15647279 more ... tungsten decreases expression ISO RGD:1552027 6480464 Tungsten results in decreased expression of EP300 mRNA CTD PMID:30912803 urethane increases expression ISO RGD:1348463 6480464 Urethane results in increased expression of EP300 mRNA CTD PMID:28818685 ursodeoxycholic acid multiple interactions ISO RGD:1348463 6480464 [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form] more ... CTD PMID:18188457 valproic acid affects expression ISO RGD:1348463 6480464 Valproic Acid affects the expression of EP300 mRNA CTD PMID:25979313 valproic acid decreases expression ISO RGD:1552027 6480464 Valproic Acid results in decreased expression of EP300 mRNA CTD PMID:32445665 valproic acid decreases methylation ISO RGD:1348463 6480464 Valproic Acid results in decreased methylation of EP300 gene CTD PMID:28853863 , PMID:29201983 vorinostat multiple interactions ISO RGD:1348463 6480464 [Vorinostat co-treated with Quercetin] results in increased expression of EP300 protein more ... CTD PMID:20421217 , PMID:30958996 zinc atom affects expression ISO RGD:1348463 6480464 Zinc affects the expression of EP300 protein CTD PMID:16636310 zinc atom multiple interactions ISO RGD:1552027 6480464 [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]] which results in increased expression of MT1 mRNA more ... CTD PMID:18458062 more ... zinc(0) affects expression ISO RGD:1348463 6480464 Zinc affects the expression of EP300 protein CTD PMID:16636310 zinc(0) multiple interactions ISO RGD:1552027 6480464 [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]] which results in increased expression of MT1 mRNA more ... CTD PMID:18458062 more ...