1-(5-isoquinolinesulfonyl)-2-methylpiperazine multiple interactions EXP 6480464 [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with Doxorubicin] results in increased expression of EP300 protein CTD PMID:15767673 1-(5-isoquinolinesulfonyl)-2-methylpiperazine increases expression EXP 6480464 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in increased expression of EP300 protein CTD PMID:15767673 11-deoxycorticosterone multiple interactions EXP 6480464 Desoxycorticosterone promotes the reaction [EP300 protein binds to SULT1A1 promoter], Desoxycorticosterone promotes the reaction [EP300 protein binds to TAT promoter] CTD PMID:22465009 17beta-estradiol multiple interactions ISO RGD:1348463 6480464 Estradiol inhibits the reaction [EP300 protein binds to COMT promoter] more ... CTD PMID:16489025 more ... 17beta-estradiol decreases expression ISO RGD:1348463 6480464 Estradiol results in decreased expression of EP300 mRNA CTD PMID:30684530 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactions ISO RGD:1348463 6480464 [Metribolone binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to EP300 protein modified form] CTD PMID:28751236 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO RGD:1348463 6480464 Curcumin inhibits the reaction [Dihydrotestosterone promotes the reaction [EP300 protein binds to KLK3 enhancer]] more ... CTD PMID:18487222 more ... 2,3,4,7,8-Pentachlorodibenzofuran multiple interactions ISO RGD:1348463 6480464 2 more ... CTD PMID:21703235 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1552027 6480464 Tetrachlorodibenzodioxin affects the expression of EP300 mRNA CTD PMID:21570461 , PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1348463 6480464 EP300 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] more ... CTD PMID:16489025 more ... 2,3,7,8-Tetrachlorodibenzofuran multiple interactions ISO RGD:1348463 6480464 2 more ... CTD PMID:21703235 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of EP300 mRNA CTD PMID:21346803 2-hydroxypropanoic acid increases expression ISO RGD:1348463 6480464 Lactic Acid results in increased expression of EP300 mRNA CTD PMID:30851411 3-aminobenzamide multiple interactions EXP 6480464 3-aminobenzamide inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA] CTD PMID:22228707 5-(2-chloroethyl)-4-methylthiazole multiple interactions ISO RGD:1552027 6480464 Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of EP300 protein] CTD PMID:24892905 5-(2-methylpiperazine-1-sulfonyl)isoquinoline multiple interactions EXP 6480464 [1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine co-treated with Doxorubicin] results in increased expression of EP300 protein CTD PMID:15767673 5-(2-methylpiperazine-1-sulfonyl)isoquinoline increases expression EXP 6480464 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine results in increased expression of EP300 protein CTD PMID:15767673 5-aza-2'-deoxycytidine affects methylation ISO RGD:1348463 6480464 Decitabine affects the methylation of EP300 promoter CTD PMID:17965222 5-aza-2'-deoxycytidine decreases expression ISO RGD:1552027 6480464 Decitabine results in decreased expression of EP300 mRNA CTD PMID:27915011 5-aza-2'-deoxycytidine multiple interactions ISO RGD:1348463 6480464 Decitabine promotes the reaction [EP300 protein binds to TP53 protein] CTD PMID:17977830 5-fluorouracil multiple interactions ISO RGD:1348463 6480464 Fluorouracil promotes the reaction [EP300 protein binds to UBE2C promoter] CTD PMID:27129209 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole multiple interactions ISO RGD:1348463 6480464 Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter], Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter] CTD PMID:21703235 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactions ISO RGD:1552027 6480464 6-chloro-2 more ... CTD PMID:25665036 8-Br-cAMP decreases expression ISO RGD:1348463 6480464 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of EP300 mRNA CTD PMID:22079614 aldehydo-D-glucose multiple interactions ISO RGD:1348463 6480464 [cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein] more ... CTD PMID:22228707 , PMID:25192544 aldehydo-D-glucose increases expression ISO RGD:1348463 6480464 Glucose results in increased expression of EP300 mRNA CTD PMID:22228707 , PMID:26045780 all-trans-retinoic acid multiple interactions ISO RGD:1552027 6480464 Tretinoin inhibits the reaction [EP300 protein binds to RETN promoter] CTD PMID:15047602 all-trans-retinoic acid increases expression ISO RGD:1348463 6480464 Tretinoin results in increased expression of EP300 mRNA CTD PMID:28053092 all-trans-retinoic acid multiple interactions ISO RGD:1348463 6480464 [GABPA protein binds to EP300 protein] promotes the reaction [Tretinoin results in increased expression of ITGB2 mRNA], EP300 protein promotes the reaction [Tretinoin results in increased expression of ITGB2 mRNA] CTD PMID:16581781 all-trans-retinyl palmitate multiple interactions EXP 6480464 retinol palmitate promotes the reaction [EP300 protein binds to MMP9 protein] CTD PMID:17164434 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of EP300 mRNA CTD PMID:16483693 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of EP300 mRNA CTD PMID:30779732 amphotericin B multiple interactions ISO RGD:1348463 6480464 Amphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:16189267 Anacardic acid decreases expression ISO RGD:1552027 6480464 anacardic acid results in decreased expression of EP300 protein CTD PMID:23297412 Anacardic acid affects activity ISO RGD:1348463 6480464 anacardic acid affects the activity of EP300 protein CTD PMID:18349320 Anacardic acid multiple interactions EXP 6480464 anacardic acid inhibits the reaction [Phenylephrine results in increased expression of EP300 protein] CTD PMID:23297412 apigenin multiple interactions ISO RGD:1348463 6480464 Apigenin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 apocynin multiple interactions ISO RGD:1348463 6480464 acetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] CTD PMID:19281832 arsenous acid increases expression ISO RGD:1348463 6480464 Arsenic Trioxide results in increased expression of EP300 mRNA CTD PMID:20458559 arsenous acid multiple interactions ISO RGD:1348463 6480464 Arsenic Trioxide promotes the reaction [EP300 protein binds to and results in increased acetylation of TP73 protein] CTD PMID:15031205 arsenous acid increases activity ISO RGD:1348463 6480464 Arsenic Trioxide results in increased activity of EP300 protein CTD PMID:15031205 berberine increases expression ISO RGD:1348463 6480464 Berberine results in increased expression of EP300 mRNA CTD PMID:27311644 bis(2-chloroethyl) sulfide decreases expression ISO RGD:1552027 6480464 Mustard Gas results in decreased expression of EP300 mRNA CTD PMID:18955075 bisphenol A multiple interactions ISO RGD:1348463 6480464 [bisphenol A binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to EP300 protein modified form] more ... CTD PMID:24533973 more ... bisphenol A affects methylation ISO RGD:1552027 6480464 bisphenol A affects the methylation of EP300 promoter CTD PMID:27334623 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of EP300 mRNA CTD PMID:25181051 butanal decreases expression ISO RGD:1348463 6480464 butyraldehyde results in decreased expression of EP300 mRNA CTD PMID:26079696 butyric acid increases expression ISO RGD:1348463 6480464 Butyric Acid results in increased expression of EP300 mRNA CTD PMID:23524101 cadmium atom multiple interactions ISO RGD:1552027 6480464 Cadmium promotes the reaction [MTF1 protein binds to EP300 protein] CTD PMID:18458062 calcitriol affects localization ISO RGD:1552027 6480464 Calcitriol affects the localization of EP300 protein CTD PMID:15647825 calcitriol multiple interactions ISO RGD:1552027 6480464 Calcitriol promotes the reaction [EP300 protein binds to CYP24A1 promoter], Calcitriol promotes the reaction [EP300 protein binds to SPP1 promoter] CTD PMID:15647825 camptothecin decreases expression ISO RGD:1348463 6480464 Camptothecin results in decreased expression of EP300 mRNA, Camptothecin results in decreased expression of EP300 protein CTD PMID:10344722 carbon nanotube decreases expression ISO RGD:1552027 6480464 Nanotubes, Carbon results in decreased expression of EP300 mRNA CTD PMID:25554681 casticin decreases expression ISO RGD:1348463 6480464 casticin results in decreased expression of EP300 mRNA CTD PMID:27862857 chromium atom increases activity ISO RGD:1552027 6480464 Chromium results in increased activity of EP300 protein CTD PMID:21467744 chromium(6+) multiple interactions ISO RGD:1552027 6480464 chromium hexavalent ion inhibits the reaction [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]], EP300 protein inhibits the reaction [chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT1 mRNA]] CTD PMID:18605988 , PMID:21467744 cilostazol affects expression ISO RGD:1552027 6480464 cilostazol affects the expression of EP300 protein CTD PMID:24254769 cilostazol multiple interactions ISO RGD:1552027 6480464 (E)-3-(2 more ... CTD PMID:24254769 cisplatin multiple interactions ISO RGD:1348463 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of EP300 mRNA more ... CTD PMID:20856196 , PMID:27392435 cisplatin increases expression ISO RGD:1552027 6480464 Cisplatin results in increased expression of EP300 protein CTD PMID:21310163 cisplatin multiple interactions ISO RGD:1552027 6480464 [PIWIL2 protein co-treated with Cisplatin] results in decreased expression of EP300 protein CTD PMID:21310163 cisplatin decreases expression ISO RGD:1348463 6480464 Cisplatin results in decreased expression of EP300 protein CTD PMID:17498666 clobetasol decreases expression ISO RGD:1552027 6480464 Clobetasol results in decreased expression of EP300 mRNA CTD PMID:27462272 cobalt dichloride multiple interactions ISO RGD:1348463 6480464 [cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein], scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:25192544 copper atom multiple interactions EXP 6480464 [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein], [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein CTD PMID:22276220 copper(0) multiple interactions EXP 6480464 [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein], [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein CTD PMID:22276220 copper(II) sulfate increases expression ISO RGD:1348463 6480464 Copper Sulfate results in increased expression of EP300 mRNA CTD PMID:19549813 curcumin multiple interactions ISO RGD:1348463 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein] more ... CTD PMID:17927689 , PMID:22258452 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [AGT protein modified form promotes the reaction [TP53 protein binds to EP300 protein]] more ... CTD PMID:22228707 , PMID:26612707 curcumin decreases activity EXP 6480464 Curcumin results in decreased activity of EP300 protein CTD PMID:26612707 curcumin decreases expression ISO RGD:1348463 6480464 Curcumin results in decreased expression of EP300 mRNA, Curcumin results in decreased expression of EP300 protein CTD PMID:17927689 curcumin affects localization ISO RGD:1348463 6480464 Curcumin affects the localization of EP300 protein CTD PMID:17927689 cyproconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of EP300 mRNA CTD PMID:29038839 cyproterone acetate multiple interactions ISO RGD:1348463 6480464 [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to EP300 protein modified form] CTD PMID:28751236 D-glucose multiple interactions ISO RGD:1348463 6480464 [cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein] more ... CTD PMID:22228707 , PMID:25192544 D-glucose increases expression ISO RGD:1348463 6480464 Glucose results in increased expression of EP300 mRNA CTD PMID:22228707 , PMID:26045780 deoxynivalenol multiple interactions ISO RGD:1348463 6480464 EP300 protein affects the reaction [deoxynivalenol results in increased expression of ATF3 protein alternative form] CTD PMID:30286430 deoxynivalenol increases expression ISO RGD:1348463 6480464 deoxynivalenol results in increased expression of EP300 protein CTD PMID:30286430 dexamethasone multiple interactions EXP 6480464 Dexamethasone promotes the reaction [EP300 protein binds to SULT1A1 promoter] more ... CTD PMID:17884810 , PMID:22465009 dexamethasone multiple interactions ISO RGD:1552027 6480464 Dexamethasone promotes the reaction [EP300 protein binds to FOXO3 gene] CTD PMID:26758684 dexamethasone multiple interactions ISO RGD:1348463 6480464 [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form] more ... CTD PMID:18188457 dextran sulfate multiple interactions ISO RGD:1552027 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of EP300 mRNA CTD PMID:29950665 diarsenic trioxide increases expression ISO RGD:1348463 6480464 Arsenic Trioxide results in increased expression of EP300 mRNA CTD PMID:20458559 diarsenic trioxide multiple interactions ISO RGD:1348463 6480464 Arsenic Trioxide promotes the reaction [EP300 protein binds to and results in increased acetylation of TP73 protein] CTD PMID:15031205 diarsenic trioxide increases activity ISO RGD:1348463 6480464 Arsenic Trioxide results in increased activity of EP300 protein CTD PMID:15031205 dibenziodolium multiple interactions ISO RGD:1348463 6480464 diphenyleneiodonium inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] CTD PMID:19281832 dicrotophos increases expression ISO RGD:1348463 6480464 dicrotophos results in increased expression of EP300 mRNA CTD PMID:28302478 diethylstilbestrol decreases expression ISO RGD:1552027 6480464 Diethylstilbestrol results in decreased expression of EP300 protein CTD PMID:15019724 diethylstilbestrol multiple interactions ISO RGD:1348463 6480464 Diethylstilbestrol promotes the reaction [EP300 protein binds to EZH2 promoter] more ... CTD PMID:24533973 , PMID:25088689 dinophysistoxin 1 affects expression ISO RGD:1348463 6480464 dinophysistoxin 1 affects the expression of EP300 mRNA CTD PMID:28939011 dioxygen multiple interactions ISO RGD:1348463 6480464 Amphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] more ... CTD PMID:16189267 , PMID:20153296 disodium selenite decreases expression ISO RGD:1348463 6480464 Sodium Selenite results in decreased expression of EP300 mRNA, Sodium Selenite results in decreased expression of EP300 protein CTD PMID:10344722 doxorubicin multiple interactions EXP 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in decreased expression of EP300 protein] more ... CTD PMID:11073966 , PMID:15767673 doxorubicin increases expression ISO RGD:1552027 6480464 Doxorubicin results in increased expression of EP300 protein CTD PMID:25665036 doxorubicin multiple interactions ISO RGD:1552027 6480464 6-chloro-2 more ... CTD PMID:25665036 doxorubicin multiple interactions ISO RGD:1348463 6480464 [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] more ... CTD PMID:19047049 doxorubicin decreases expression ISO RGD:1348463 6480464 Doxorubicin results in decreased expression of EP300 mRNA, Doxorubicin results in decreased expression of EP300 protein CTD PMID:10344722 , PMID:17498666 doxorubicin increases degradation EXP 6480464 Doxorubicin results in increased degradation of EP300 protein CTD PMID:11073966 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of EP300 mRNA, Doxorubicin results in decreased expression of EP300 protein CTD PMID:11073966 more ... doxorubicin decreases response to substance ISO RGD:1552027 6480464 EP300 protein results in decreased susceptibility to Doxorubicin CTD PMID:14975762 doxorubicin decreases expression ISO RGD:1552027 6480464 Doxorubicin results in decreased expression of EP300 protein CTD PMID:14975762 ellagic acid increases expression ISO RGD:1348463 6480464 Ellagic Acid results in increased expression of EP300 mRNA CTD PMID:12002526 entinostat multiple interactions ISO RGD:1348463 6480464 entinostat promotes the reaction [EP300 protein binds to RELA protein] CTD PMID:20421217 epoxiconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of EP300 mRNA CTD PMID:29038839 ethanol decreases expression ISO RGD:1552027 6480464 Ethanol results in decreased expression of EP300 protein CTD PMID:24892905 ethanol multiple interactions ISO RGD:1552027 6480464 Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of EP300 protein] CTD PMID:24892905 etoposide multiple interactions ISO RGD:1348463 6480464 [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein] more ... CTD PMID:19047049 fisetin multiple interactions ISO RGD:1348463 6480464 fisetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 flavone multiple interactions ISO RGD:1348463 6480464 flavone inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 furan decreases expression EXP 6480464 furan results in decreased expression of EP300 mRNA CTD PMID:24614236 galangin multiple interactions ISO RGD:1348463 6480464 galangin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 gallic acid multiple interactions ISO RGD:1348463 6480464 [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein] more ... CTD PMID:27634460 Garcinol multiple interactions ISO RGD:1348463 6480464 garcinol inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] CTD PMID:19281832 genistein multiple interactions ISO RGD:1348463 6480464 EP300 promotes the reaction [Genistein promotes the reaction [trichostatin A results in increased expression of TP53 mRNA]] more ... CTD PMID:26768552 , PMID:30684530 genistein decreases expression ISO RGD:1348463 6480464 Genistein results in decreased expression of EP300 mRNA CTD PMID:30684530 genistein increases expression ISO RGD:1348463 6480464 Genistein results in increased expression of EP300 protein CTD PMID:26768552 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of EP300 mRNA CTD PMID:22061828 glucose multiple interactions ISO RGD:1348463 6480464 [cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein] more ... CTD PMID:22228707 , PMID:25192544 glucose increases expression ISO RGD:1348463 6480464 Glucose results in increased expression of EP300 mRNA CTD PMID:22228707 , PMID:26045780 gold atom multiple interactions ISO RGD:1348463 6480464 [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein] more ... CTD PMID:27634460 , PMID:28433809 gold(0) multiple interactions ISO RGD:1348463 6480464 [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein] more ... CTD PMID:27634460 , PMID:28433809 hyaluronic acid multiple interactions ISO RGD:1348463 6480464 [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] more ... CTD PMID:19047049 irinotecan decreases expression ISO RGD:1348463 6480464 Irinotecan metabolite results in decreased expression of EP300 mRNA, Irinotecan results in decreased expression of EP300 mRNA CTD PMID:15956246 kaempferol multiple interactions ISO RGD:1348463 6480464 kaempferol promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 kojic acid increases expression ISO RGD:1348463 6480464 kojic acid results in increased expression of EP300 mRNA CTD PMID:16595896 KT 5720 multiple interactions ISO RGD:1552027 6480464 KT 5720 inhibits the reaction [cilostazol affects the expression of EP300 protein] CTD PMID:24254769 lead(0) increases expression EXP 6480464 Lead results in increased expression of EP300 mRNA CTD PMID:24291742 lead(2+) increases expression EXP 6480464 Lead results in increased expression of EP300 mRNA CTD PMID:24291742 LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SIRT6 protein affects the phosphorylation of EP300 protein] CTD PMID:27094368 menadione decreases expression ISO RGD:1348463 6480464 Vitamin K 3 results in decreased expression of EP300 protein CTD PMID:31238027 miconazole decreases expression EXP 6480464 Miconazole results in decreased expression of EP300 mRNA CTD PMID:22262564 miconazole decreases expression ISO RGD:1552027 6480464 Miconazole results in decreased expression of EP300 mRNA CTD PMID:27462272 mono(2-ethylhexyl) phthalate multiple interactions ISO RGD:1348463 6480464 mono-(2-ethylhexyl)phthalate promotes the reaction [PPARA protein binds to EP300 protein] CTD PMID:20123618 myricetin multiple interactions ISO RGD:1348463 6480464 myricetin promotes the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 N-acetyl-L-cysteine multiple interactions ISO RGD:1348463 6480464 Acetylcysteine inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] CTD PMID:19281832 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:1348463 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Curcumin affects the localization of EP300 protein] more ... CTD PMID:17927689 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased degradation of EP300 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SIRT6 protein results in decreased expression of EP300 protein] CTD PMID:15767673 , PMID:27094368 Niclosamide increases expression ISO RGD:1348463 6480464 Niclosamide results in increased expression of EP300 mRNA CTD PMID:22576131 nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of EP300 mRNA, nitrofen results in decreased expression of EP300 protein CTD PMID:24488106 ochratoxin A decreases expression ISO RGD:1348463 6480464 ochratoxin A results in decreased expression of EP300 mRNA CTD PMID:30763683 okadaic acid decreases expression ISO RGD:1348463 6480464 Okadaic Acid results in decreased expression of EP300 mRNA CTD PMID:28939011 omeprazole multiple interactions ISO RGD:1348463 6480464 Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter], Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter] CTD PMID:21703235 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of EP300 mRNA CTD PMID:25729387 p-menthan-3-ol decreases expression ISO RGD:1348463 6480464 Menthol results in decreased expression of EP300 mRNA CTD PMID:26760959 phenylephrine multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased expression of EP300 mRNA] more ... CTD PMID:11705990 more ... phenylephrine increases response to substance EXP 6480464 EP300 protein results in increased susceptibility to Phenylephrine CTD PMID:12477714 phenylephrine multiple interactions ISO RGD:1348463 6480464 EP300 protein promotes the reaction [[Phenylephrine results in increased activity of GATA4 protein] which results in increased expression of EDN1 mRNA] CTD PMID:12724418 phenylephrine increases expression EXP 6480464 Phenylephrine results in increased expression of EP300 mRNA, Phenylephrine results in increased expression of EP300 protein CTD PMID:11705990 more ... phlorizin decreases expression ISO RGD:1552027 6480464 Phlorhizin results in decreased expression of EP300 mRNA CTD PMID:22538082 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1348463 6480464 Arsenicals promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [NFE2L2 protein binds to EP300 protein]], Tetradecanoylphorbol Acetate promotes the reaction [NFE2L2 protein binds to EP300 protein] CTD PMID:24632381 pirinixic acid multiple interactions ISO RGD:1552027 6480464 pirinixic acid promotes the reaction [PPARA protein binds to EP300 protein] CTD PMID:20123618 pirinixic acid multiple interactions ISO RGD:1348463 6480464 pirinixic acid promotes the reaction [PPARA protein binds to EP300 protein] CTD PMID:20123618 prochloraz multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of EP300 mRNA CTD PMID:29038839 prostaglandin E2 multiple interactions ISO RGD:1348463 6480464 Dinoprostone promotes the reaction [EP300 protein binds to CYP19A1 promoter] more ... CTD PMID:30409902 prostaglandin J2 decreases activity ISO RGD:1348463 6480464 9-deoxy-delta-9-prostaglandin D2 results in decreased activity of EP300 protein CTD PMID:22141352 pyrazinecarboxamide decreases expression EXP 6480464 Pyrazinamide results in decreased expression of EP300 mRNA CTD PMID:22431067 quercetin decreases expression ISO RGD:1348463 6480464 Quercetin results in decreased expression of EP300 protein CTD PMID:15580028 quercetin multiple interactions ISO RGD:1348463 6480464 [trichostatin A co-treated with Quercetin] results in increased expression of EP300 protein more ... CTD PMID:20153296 more ... rac-lactic acid increases expression ISO RGD:1348463 6480464 Lactic Acid results in increased expression of EP300 mRNA CTD PMID:30851411 resveratrol decreases expression ISO RGD:1552027 6480464 resveratrol results in decreased expression of EP300 protein CTD PMID:23297412 resveratrol decreases expression ISO RGD:1348463 6480464 resveratrol results in decreased expression of EP300 mRNA, resveratrol results in decreased expression of EP300 protein CTD PMID:25707573 resveratrol increases expression ISO RGD:1348463 6480464 resveratrol results in increased expression of EP300 mRNA CTD PMID:12002526 , PMID:12569576 resveratrol multiple interactions ISO RGD:1552027 6480464 6-chloro-2 more ... CTD PMID:23297412 , PMID:25665036 resveratrol affects expression ISO RGD:1552027 6480464 resveratrol affects the expression of EP300 protein CTD PMID:24254769 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [Phenylephrine promotes the reaction [EP300 protein binds to NPPA promoter]], resveratrol inhibits the reaction [Phenylephrine results in increased expression of EP300 protein] CTD PMID:23297412 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of EP300 mRNA, resveratrol results in decreased expression of EP300 protein CTD PMID:23297412 , PMID:25905778 resveratrol multiple interactions ISO RGD:1348463 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [resveratrol promotes the reaction [PTGS2 protein binds to EP300 protein]] more ... CTD PMID:16928824 more ... SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [Doxorubicin results in decreased expression of EP300 protein], SB 203580 inhibits the reaction [MAP2K6 protein results in decreased expression of EP300 protein] CTD PMID:15767673 scutellarin multiple interactions ISO RGD:1348463 6480464 scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:25192544 Se-methyl-L-selenocysteine multiple interactions ISO RGD:1348463 6480464 selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter] CTD PMID:25321483 Se-methylselenocysteine multiple interactions ISO RGD:1348463 6480464 selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter] CTD PMID:25321483 silicon dioxide decreases expression ISO RGD:1348463 6480464 Silicon Dioxide results in decreased expression of EP300 mRNA CTD PMID:23623845 sirtinol multiple interactions ISO RGD:1552027 6480464 sirtinol inhibits the reaction [cilostazol affects the expression of EP300 protein], sirtinol inhibits the reaction [resveratrol inhibits the reaction [Doxorubicin results in increased expression of EP300 protein]] CTD PMID:24254769 , PMID:25665036 sodium arsenite multiple interactions ISO RGD:1348463 6480464 sodium arsenite inhibits the reaction [EP300 protein binds to IVL promoter] CTD PMID:20006635 sodium arsenite decreases expression ISO RGD:1552027 6480464 sodium arsenite results in decreased expression of EP300 mRNA, sodium arsenite results in decreased expression of EP300 protein CTD PMID:30130555 sodium fluoride decreases expression ISO RGD:1552027 6480464 Sodium Fluoride results in decreased expression of EP300 mRNA CTD PMID:27862939 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of EP300 mRNA CTD PMID:22228707 streptozocin multiple interactions EXP 6480464 3-aminobenzamide inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA], Curcumin inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA] CTD PMID:22228707 sulforaphane multiple interactions ISO RGD:1348463 6480464 sulforafan inhibits the reaction [EP300 protein binds to COMT promoter] CTD PMID:30684530 sunitinib increases expression ISO RGD:1348463 6480464 Sunitinib results in increased expression of EP300 mRNA CTD PMID:31533062 superoxide decreases abundance ISO RGD:1348463 6480464 EP300 protein results in decreased abundance of Superoxides CTD PMID:25440059 tamoxifen multiple interactions ISO RGD:1348463 6480464 Tamoxifen inhibits the reaction [ESR1 protein binds to EP300 protein] CTD PMID:23665804 tetrathiomolybdate(2-) multiple interactions EXP 6480464 [Copper deficiency co-treated with tetrathiomolybdate] inhibits the reaction [EP300 protein binds to HIF1A protein], [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of EP300 protein CTD PMID:22276220 titanium dioxide decreases expression ISO RGD:1552027 6480464 titanium dioxide results in decreased expression of EP300 mRNA CTD PMID:29264374 titanium dioxide multiple interactions ISO RGD:1552027 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of EP300 mRNA CTD PMID:29950665 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of EP300 mRNA CTD PMID:25729387 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of EP300 mRNA CTD PMID:25729387 trichostatin A affects localization ISO RGD:1348463 6480464 trichostatin A affects the localization of EP300 protein CTD PMID:15647279 trichostatin A affects expression ISO RGD:1348463 6480464 trichostatin A affects the expression of EP300 mRNA CTD PMID:28542535 trichostatin A increases response to substance EXP 6480464 EP300 protein results in increased susceptibility to trichostatin A CTD PMID:12477714 trichostatin A multiple interactions ISO RGD:1348463 6480464 [trichostatin A co-treated with Quercetin] results in increased expression of EP300 protein more ... CTD PMID:15647279 more ... tungsten decreases expression ISO RGD:1552027 6480464 Tungsten results in decreased expression of EP300 mRNA CTD PMID:30912803 urethane increases expression ISO RGD:1348463 6480464 Urethane results in increased expression of EP300 mRNA CTD PMID:28818685 ursodeoxycholic acid multiple interactions ISO RGD:1348463 6480464 [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form] more ... CTD PMID:18188457 valproic acid affects expression ISO RGD:1348463 6480464 Valproic Acid affects the expression of EP300 mRNA CTD PMID:25979313 valproic acid decreases methylation ISO RGD:1348463 6480464 Valproic Acid results in decreased methylation of EP300 gene CTD PMID:28853863 , PMID:29201983 vorinostat multiple interactions ISO RGD:1348463 6480464 [Vorinostat co-treated with Quercetin] results in increased expression of EP300 protein more ... CTD PMID:20421217 , PMID:30958996 zinc atom affects expression ISO RGD:1348463 6480464 Zinc affects the expression of EP300 protein CTD PMID:16636310 zinc atom multiple interactions ISO RGD:1552027 6480464 [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]] which results in increased expression of MT1 mRNA more ... CTD PMID:18458062 more ... zinc(0) affects expression ISO RGD:1348463 6480464 Zinc affects the expression of EP300 protein CTD PMID:16636310 zinc(0) multiple interactions ISO RGD:1552027 6480464 [Zinc promotes the reaction [MTF1 protein binds to EP300 protein]] which results in increased expression of MT1 mRNA more ... CTD PMID:18458062 more ...
Biological Process animal organ morphogenesis ISO RGD:1552027 1624291 MGI:MGI:2679374 (MGI:MGI:2677590 , PMID:14517255) RGD MGI:MGI:2677590 , PMID:14517255 apoptotic process ISO RGD:1348463 1624291 (PMID:9194565) RGD PMID:9194565 B cell differentiation ISO RGD:1552027 1624291 MGI:MGI:3813243 (MGI:MGI:3812266 , PMID:18684867) RGD MGI:MGI:3812266 , PMID:18684867 behavioral defense response ISO RGD:1552027 1624291 (MGI:MGI:4421646, PMID:19822209) RGD MGI:MGI:4421646 , PMID:19822209 cellular response to antibiotic IEP 7327216 RGD cellular response to cAMP IEP 5688346 RGD cellular response to dexamethasone stimulus IEP 7327218 RGD cellular response to drug IEP 7364728 valproic acid RGD cellular response to glucose stimulus IEP 7327187 RGD cellular response to hydrogen peroxide IEP 2289910 RGD cellular response to mineralocorticoid stimulus IEP 7327218 11-deoxycorticosterone RGD cellular response to nerve growth factor stimulus IEP 7364749 RGD cellular response to organic cyclic compound IEP 7327143 curcumin RGD cellular response to retinoic acid IEP 7364732 RGD cellular response to trichostatin A IEP 7364756 RGD cellular response to UV ISO RGD:1348463 1624291 (PMID:24939902) RGD PMID:24939902 circadian rhythm ISO RGD:1552027 1624291 (MGI:MGI:5559671, PMID:14645221) RGD MGI:MGI:5559671 , PMID:14645221 digestive tract development IEP 2312267 RGD face morphogenesis ISO RGD:1552027 1624291 (MGI:MGI:4421646, PMID:19822209) RGD MGI:MGI:4421646 , PMID:19822209 fat cell differentiation ISO RGD:1552027 1624291 (MGI:MGI:5688824, PMID:24216764) RGD MGI:MGI:5688824 , PMID:24216764 heart development ISO RGD:1552027 1624291 MGI:MGI:2679374 (MGI:MGI:2677590 , PMID:14517255) RGD MGI:MGI:2677590 , PMID:14517255 histone acetylation IMP 2312266 RGD histone acetylation ISO RGD:1348463 1624291 (PMID:25818647), (PMID:27256286) RGD PMID:25818647 , PMID:27256286 histone acetylation IEA GO:0004402 1600115 GO_REF:0000108 GOC GO_REF:0000108 histone acetylation ISO RGD:1552027 1624291 (MGI:MGI:5908770, PMID:27105113) RGD MGI:MGI:5908770 , PMID:27105113 histone H2B acetylation ISO RGD:1348463 1624291 (PMID:23415232) RGD PMID:23415232 histone H3 acetylation IMP 7327209 RGD histone H4 acetylation ISO RGD:1348463 1624291 (PMID:16325578) RGD PMID:16325578 internal peptidyl-lysine acetylation ISO RGD:1348463 1624291 (PMID:17403783) RGD PMID:17403783 internal peptidyl-lysine acetylation IMP 7349318 Rela RGD internal protein amino acid acetylation ISO RGD:1348463 1624291 (PMID:18722353) RGD PMID:18722353 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO RGD:1348463 1624291 (PMID:17403783) RGD PMID:17403783 learning or memory ISO RGD:1552027 1624291 (MGI:MGI:4421646, PMID:19822209) RGD MGI:MGI:4421646 , PMID:19822209 liver development IEP 1581923 RGD lung development ISO RGD:1552027 1624291 MGI:MGI:2679374 (MGI:MGI:2677590 , PMID:14517255) RGD MGI:MGI:2677590 , PMID:14517255 macrophage derived foam cell differentiation ISO RGD:1348463 1624291 (PMID:26504087) RGD PMID:26504087 megakaryocyte development ISO RGD:1552027 1624291 MGI:MGI:3813243 (MGI:MGI:3812266 , PMID:18684867) RGD MGI:MGI:3812266 , PMID:18684867 memory IEP 9588306 RGD multicellular organism growth ISO RGD:1552027 1624291 (MGI:MGI:4421646, PMID:19822209) RGD MGI:MGI:4421646 , PMID:19822209 N-terminal peptidyl-lysine acetylation ISO RGD:1348463 1624291 (PMID:12435739) RGD PMID:12435739 negative regulation of cell death IMP 7327216 cardiac myocytes RGD negative regulation of cellular metabolic process IMP 2311718 in CoCl2-treated PC12 cells RGD negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP 7327216 cardiac myocytes RGD negative regulation of gluconeogenesis ISO RGD:1348463 1624291 (PMID:30193097) RGD PMID:30193097 negative regulation of miRNA metabolic process IMP 7349314 RGD negative regulation of protein-containing complex assembly ISO RGD:1348463 1624291 (PMID:23962722) RGD PMID:23962722 negative regulation of transcription by RNA polymerase II ISO RGD:1348463 1624291 (PMID:10733570) RGD PMID:10733570 peptidyl-lysine acetylation IMP 2312280 RGD peptidyl-lysine acetylation ISO RGD:1348463 1624291 (PMID:23811396), (PMID:23962722) RGD PMID:23811396 , PMID:23962722 peptidyl-lysine butyrylation ISO RGD:1348463 1624291 (PMID:17267393), (PMID:29775581) RGD PMID:17267393 , PMID:29775581 peptidyl-lysine butyrylation ISO RGD:1552027 1624291 (MGI:MGI:5908770, PMID:27105113) RGD MGI:MGI:5908770 , PMID:27105113 peptidyl-lysine crotonylation ISO RGD:1348463 1624291 (PMID:25818647) RGD PMID:25818647 peptidyl-lysine propionylation ISO RGD:1348463 1624291 (PMID:17267393) RGD PMID:17267393 platelet formation ISO RGD:1552027 1624291 MGI:MGI:3813243 more ... RGD MGI:MGI:3812266 , PMID:18684867 positive regulation by host of viral transcription ISO RGD:1348463 1624291 (PMID:16687403) RGD PMID:16687403 positive regulation of axon extension IMP 2308917 RGD positive regulation of cell death IMP 7327146 RGD positive regulation of cell growth IMP 2289918 RGD positive regulation of cell growth involved in cardiac muscle cell development IMP 2312280 RGD positive regulation of cell size IMP 7327187 cardiomyocyte RGD positive regulation of cellular metabolic process IMP 2311713 in hypoxia-treated PC12 cells RGD positive regulation of collagen biosynthetic process IMP 2312266 RGD positive regulation of DNA binding IMP 2311715 RGD positive regulation of DNA-binding transcription factor activity IMP 2311715 RGD positive regulation of DNA-binding transcription factor activity ISO RGD:1348463 1624291 (PMID:10518217), (PMID:25818647) RGD PMID:10518217 , PMID:25818647 positive regulation of DNA-binding transcription factor activity ISO RGD:1552027 1624291 (MGI:MGI:5571645, PMID:24565863) RGD MGI:MGI:5571645 , PMID:24565863 positive regulation of gene expression IDA 2312262 RGD positive regulation of gene expression ISO RGD:1552027 1624291 MGI:MGI:1098280 (MGI:MGI:5441401 , PMID:22523253) RGD MGI:MGI:5441401 , PMID:22523253 positive regulation of gene expression IMP 7327210 Mmp9 RGD positive regulation of gene expression, epigenetic ISO RGD:1348463 1624291 (PMID:25818647) RGD PMID:25818647 positive regulation of glycoprotein biosynthetic process IMP 2312275 fibronectin RGD positive regulation of histone acetylation IMP 9588307 RGD positive regulation of muscle atrophy IMP 7349318 RGD positive regulation of neuron projection development ISO RGD:1348463 1624291 (PMID:27256286) RGD PMID:27256286 positive regulation of NIK/NF-kappaB signaling ISO RGD:1348463 1624291 (PMID:23811396) RGD PMID:23811396 positive regulation of nucleic acid-templated transcription IEA GO:0003713 1600115 GO_REF:0000108 GOC GO_REF:0000108 positive regulation of protein acetylation IMP 7327214 Stat3 RGD positive regulation of protein binding ISO RGD:1552027 1624291 (MGI:MGI:3690196, PMID:16619037) RGD MGI:MGI:3690196 , PMID:16619037 positive regulation of protein import into nucleus IMP 2312266 Smad-2/3/4 RGD positive regulation of protein phosphorylation IMP 2312266 Smad-2 RGD positive regulation of protein phosphorylation IMP 7327214 Stat3 RGD positive regulation of protein secretion IMP 1298794 atrial natriuretic protein RGD positive regulation of proteolysis IMP 2289912 RGD positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding ISO RGD:1348463 1624291 (PMID:23811396) RGD PMID:23811396 positive regulation of sarcomere organization IMP 2312280 RGD positive regulation of transcription by RNA polymerase II IMP 1581923 RGD positive regulation of transcription by RNA polymerase II ISO RGD:1348463 1624291 (PMID:12586840), (PMID:16325578), (PMID:18722353), (PMID:23811396) RGD PMID:12586840 more ... positive regulation of transcription by RNA polymerase II ISO RGD:1552027 1624291 MGI:MGI:103302 more ... RGD MGI:MGI:3053497 more ... positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response ISO RGD:1552027 1624291 (MGI:MGI:5607229, PMID:20955178) RGD MGI:MGI:5607229 , PMID:20955178 positive regulation of transcription, DNA-templated ISO RGD:1552027 1624291 (MGI:MGI:3041015 more ... RGD MGI:MGI:3041015 more ... positive regulation of transforming growth factor beta receptor signaling pathway ISO RGD:1348463 1624291 (PMID:25514493) RGD PMID:25514493 positive regulation of translation IMP 1298794 increase in protein:DNA ratio RGD protein acetylation ISO RGD:1348463 1624291 (PMID:21030595), (PMID:24939902) RGD PMID:21030595 , PMID:24939902 protein acetylation ISO RGD:1552027 1624291 (MGI:MGI:5607229 more ... RGD MGI:MGI:5607229 more ... protein destabilization ISO RGD:1348463 1624291 (PMID:24939902) RGD PMID:24939902 protein kinase B signaling IDA 2312264 RGD protein stabilization ISO RGD:1552027 1624291 (MGI:MGI:5607229, PMID:20955178) RGD MGI:MGI:5607229 , PMID:20955178 protein-DNA complex assembly IDA 2312285 p53, CBP, p21/WAF1 promoter RGD regulation of androgen receptor signaling pathway ISO RGD:1348463 1624291 (PMID:18487222) RGD PMID:18487222 regulation of angiotensin metabolic process IDA 2312269 RGD regulation of glycolytic process ISO RGD:1348463 1624291 (PMID:29775581) RGD PMID:29775581 regulation of mitochondrion organization ISO RGD:1552027 1624291 (MGI:MGI:6287163, PMID:25200183) RGD MGI:MGI:6287163 , PMID:25200183 regulation of transcription by RNA polymerase II ISO RGD:1552027 1624291 (MGI:MGI:2154675 more ... RGD MGI:MGI:2154675 more ... regulation of transcription, DNA-templated ISO RGD:1348463 1624291 (PMID:15261140) RGD PMID:15261140 regulation of transcription, DNA-templated IEA InterPro:IPR000197 more ... 1600115 GO_REF:0000002 InterPro GO_REF:0000002 regulation of tubulin deacetylation ISO RGD:1348463 1624291 (PMID:18722353) RGD PMID:18722353 response to calcium ion IMP 2289914 RGD response to cobalt ion IEP 2311718 CoCl2 (hypoxia mimic) RGD response to dexamethasone IMP 2289912 RGD response to drug IMP 2289918 RGD response to estrogen IEP 2312276 RGD response to estrogen ISO RGD:1348463 1624291 (PMID:11581164) RGD PMID:11581164 response to ethanol IEP 2289911 RGD response to fatty acid IEP 2312267 RGD response to glucose IMP 2312263 RGD response to hydrogen peroxide IEP 2289910 RGD response to hypoxia IEP 2311713 ; 2289914 RGD response to hypoxia ISO RGD:1348463 1624291 (PMID:15261140), (PMID:9887100) RGD PMID:15261140 , PMID:9887100 response to organic cyclic compound IEP 2312265 alpha1-adrenergic agonist phenylephrine RGD response to retinoic acid IEP 1642048 RGD response to tumor necrosis factor IEP 2312262 RGD skeletal muscle tissue development ISO RGD:1552027 1624291 MGI:MGI:2679374 (MGI:MGI:2677591 , PMID:14517256) RGD MGI:MGI:2677591 , PMID:14517256 somitogenesis ISO RGD:1552027 1624291 MGI:MGI:1343101 (MGI:MGI:3583034 , PMID:15937931) RGD MGI:MGI:3583034 , PMID:15937931 swimming ISO RGD:1552027 1624291 (MGI:MGI:4421646, PMID:19822209) RGD MGI:MGI:4421646 , PMID:19822209 thigmotaxis ISO RGD:1552027 1624291 (MGI:MGI:4421646, PMID:19822209) RGD MGI:MGI:4421646 , PMID:19822209 Cellular Component chromatin IDA 5128544 RGD cytoplasm IDA 2311713 RGD cytosol ISO RGD:1348463 1624291 RGD GO_REF:0000052 histone acetyltransferase complex ISO RGD:1552027 1624291 (MGI:MGI:1344193, PMID:9742083) RGD MGI:MGI:1344193 , PMID:9742083 host cell nucleus IEA InterPro:IPR000197 1600115 GO_REF:0000002 InterPro GO_REF:0000002 nucleoplasm ISO RGD:1348463 1624291 RGD GO_REF:0000052 nucleoplasm TAS 1600115 Reactome:R-RNO-9622586 Reactome Reactome:R-RNO-9622586 nucleoplasm TAS 1600115 Reactome:R-RNO-9622571 Reactome Reactome:R-RNO-9622571 nucleus IDA 2289909 ; 9588306 ; 2312280 RGD nucleus ISO RGD:1348463 1624291 (PMID:12929931), (PMID:14645221), (PMID:9194565) RGD PMID:12929931 more ... protein-containing complex ISO RGD:1552027 1624291 (MGI:MGI:3613433, PMID:15616592) RGD MGI:MGI:3613433 , PMID:15616592 protein-DNA complex IDA 2316171 RGD protein-DNA complex IPI UniProtKB:A0A0G2K5M1 , UniProtKB:Q01714 13506263 PMID:10362258 ARUK-UCL transcription regulator complex IC GO:0008134 1581923 RGD transcription regulator complex ISO RGD:1552027 1624291 (MGI:MGI:2446944 more ... RGD MGI:MGI:2446944 more ... Molecular Function acetyltransferase activity ISO RGD:1552027 1624291 (MGI:MGI:5571645 more ... RGD MGI:MGI:5571645 more ... acetyltransferase activity ISO RGD:1348463 1624291 (PMID:12435739), (PMID:12456660), (PMID:16135789), (PMID:18722353), (PMID:20228809), (PMID:23811396), (PMID:24939902) RGD PMID:12435739 more ... activating transcription factor binding IPI RGD:2041 1581923 RGD activating transcription factor binding ISO RGD:1348463 1624291 UniProtKB:Q02078 (PMID:20590529) RGD PMID:20590529 activating transcription factor binding IPI RGD:621445 7364714 RGD activating transcription factor binding IPI RGD:3828 1581923 RGD androgen receptor binding ISO RGD:1348463 1624291 UniProtKB:P10275 (PMID:18487222) RGD PMID:18487222 antigen binding IDA 2312283 adenovirus E1A RGD beta-catenin binding ISO RGD:1348463 1624291 UniProtKB:Q02248 (PMID:12408825) RGD PMID:12408825 bHLH transcription factor binding IPI RGD:620914 , RGD:620218 2312273 RGD chromatin binding IDA 7327140 RGD chromatin binding ISO RGD:1552027 1624291 (MGI:MGI:5442240 more ... RGD MGI:MGI:5442240 more ... chromatin binding ISO RGD:1348463 1624291 (PMID:17641689), (PMID:24939902), (PMID:25818647) RGD PMID:17641689 more ... chromatin DNA binding ISO RGD:1552027 1624291 (MGI:MGI:3796777, PMID:18458156) RGD MGI:MGI:3796777 , PMID:18458156 chromatin DNA binding IDA 5128544 RGD cis-regulatory region sequence-specific DNA binding IDA 2311715 RGD damaged DNA binding ISO RGD:1348463 1624291 (PMID:24939902) RGD PMID:24939902 DNA binding ISO RGD:1552027 1624291 (MGI:MGI:3525928 more ... RGD MGI:MGI:3525928 more ... DNA binding ISO RGD:1348463 1624291 (PMID:9194565) RGD PMID:9194565 glucocorticoid receptor binding IDA 2312268 RGD histone acetyltransferase activity IDA 7364713 RGD histone acetyltransferase activity IEA InterPro:IPR000197 1600115 GO_REF:0000002 InterPro GO_REF:0000002 histone acetyltransferase activity ISO RGD:1552027 1624291 (MGI:MGI:5908770, PMID:27105113) RGD MGI:MGI:5908770 , PMID:27105113 histone acetyltransferase activity ISO RGD:1348463 1624291 (PMID:12040021), (PMID:14645221), (PMID:23415232), (PMID:25818647) RGD PMID:12040021 more ... histone butyryltransferase activity ISO RGD:1552027 1624291 (MGI:MGI:5908770, PMID:27105113) RGD MGI:MGI:5908770 , PMID:27105113 histone crotonyltransferase activity ISO RGD:1348463 1624291 (PMID:25818647) RGD PMID:25818647 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO RGD:1348463 1624291 (PMID:20019387) RGD PMID:20019387 mitogen-activated protein kinase binding IPI RGD:70500 2312282 RGD NF-kappaB binding IPI RGD:727889 2312270 RGD NF-kappaB binding ISO RGD:1348463 1624291 UniProtKB:P19838:PRO_0000030311 , UniProtKB:Q04206 (PMID:23811396) RGD PMID:23811396 nuclear hormone receptor binding ISO RGD:1348463 1624291 UniProtKB:P35398 (PMID:9862959) RGD PMID:9862959 p53 binding IPI RGD:3889 7349387 RGD p53 binding ISO RGD:1552027 1624291 PR:P02340 (MGI:MGI:3720993, PMID:17591690) RGD MGI:MGI:3720993 , PMID:17591690 peptide butyryltransferase activity ISO RGD:1348463 1624291 (PMID:17267393), (PMID:29775581) RGD PMID:17267393 , PMID:29775581 peptide-lysine-N-acetyltransferase activity ISO RGD:1552027 1624291 (MGI:MGI:6287163, PMID:25200183) RGD MGI:MGI:6287163 , PMID:25200183 peroxisome proliferator activated receptor binding IDA 632678 RGD pre-mRNA intronic binding ISO RGD:1552027 1624291 (MGI:MGI:5500979, PMID:23752591) RGD MGI:MGI:5500979 , PMID:23752591 promoter-specific chromatin binding IDA 7364713 RGD protein antigen binding IPI UniProtKB:P03070 2312284 RGD protein binding IPI RGD:2583 7257571 RGD protein binding ISO RGD:1552027 1624291 PR:P06876 more ... RGD MGI:MGI:1344193 more ... protein binding ISO RGD:1348463 1624291 UniProtKB:K4P3M7 more ... RGD PMID:10049825 more ... protein binding IPI RGD:70976 7364726 RGD protein binding IPI RGD:2327 2312276 LAP and LIP isoforms RGD protein binding IPI UniProtKB:P03129 2312279 RGD protein binding IPI RGD:1305902 9590266 RGD protein binding IPI RGD:1309196 7349318 Foxo3 RGD protein binding IPI RGD:620520 2289909 RGD protein binding IPI RGD:2319357 7327214 RGD protein C-terminus binding ISO RGD:1348463 1624291 (PMID:17150957) RGD PMID:17150957 protein kinase binding IPI RGD:1359638 9698419 RGD protein propionyltransferase activity ISO RGD:1348463 1624291 (PMID:17267393) RGD PMID:17267393 protein-containing complex binding IDA 2312281 C complex, E-CRE complex RGD protein-containing complex binding IPI RGD:2126 , RGD:61928 2312278 RGD RNA polymerase II activating transcription factor binding ISO RGD:1552027 1624291 PR:Q07243 (MGI:MGI:3820854, PMID:18605988) RGD MGI:MGI:3820854 , PMID:18605988 RNA polymerase II activating transcription factor binding ISO RGD:1348463 1624291 UniProtKB:P18146 more ... RGD PMID:20018936 , PMID:23811396 RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 1581923 ; 5128544 RGD RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:1552027 1624291 (MGI:MGI:5500979, PMID:23752591) RGD MGI:MGI:5500979 , PMID:23752591 RNA polymerase II transcription factor binding ISO RGD:1552027 1624291 PR:Q07243 (MGI:MGI:3820854, PMID:18605988) RGD MGI:MGI:3820854 , PMID:18605988 RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO RGD:1348463 1624291 (PMID:23811396) RGD PMID:23811396 SMAD binding IPI RGD:3031 , RGD:3032 2301880 RGD STAT family protein binding ISO RGD:1348463 1624291 UniProtKB:P42224 (PMID:26479788) RGD PMID:26479788 transcription coactivator activity ISO RGD:1348463 1624291 UniProtKB:P19838:PRO_0000030311 , UniProtKB:Q04206 (PMID:11940591), (PMID:12435739), (PMID:12586840), (PMID:12929931), (PMID:16687403), (PMID:17641689), (PMID:18487222), (PMID:23811396) RGD PMID:11940591 more ... transcription coactivator activity IGI UniProtKB:A0A0G2K5M1 , UniProtKB:Q01714 13506263 PMID:10362258 ARUK-UCL transcription coactivator activity ISO RGD:1552027 1624291 (MGI:MGI:5297783, PMID:17641689) RGD MGI:MGI:5297783 , PMID:17641689 transcription factor binding IPI RGD:620218 7257571 RGD transcription factor binding IPI UniProtKB:Q01714 13506263 PMID:10362258 ARUK-UCL transcription factor binding ISO RGD:1348463 1624291 UniProtKB:P40763 more ... RGD PMID:11349124 more ... transcription factor binding ISO RGD:1552027 1624291 UniProtKB:P28033 more ... RGD MGI:MGI:5297783 more ... transcription factor binding IPI RGD:3738 2316171 RGD transcription factor binding IPI RGD:2665 2312265 RGD transcription factor binding IDA 2312277 NFATc1 RGD transcription factor binding IPI RGD:3772 2306467 RGD transferase activity, transferring acyl groups ISO RGD:1348463 1624291 (PMID:17403783) RGD PMID:17403783 zinc ion binding IEA InterPro:IPR000197 1600115 GO_REF:0000002 InterPro GO_REF:0000002
Gene-Chemical Interaction Annotations
