(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1343311 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD3 mRNA CTD PMID:22079256 (S)-nicotine multiple interactions ISO RGD:735647 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 (S)-nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of SMAD3 mRNA CTD PMID:29660438 (S)-nicotine multiple interactions EXP 6480464 Nicotine results in increased expression of and results in increased phosphorylation of SMAD3 protein CTD PMID:22691361 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression ISO RGD:735647 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO RGD:735647 6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 1-O-oleoyl-sn-glycero-3-phosphocholine decreases abundance ISO RGD:735647 6480464 SMAD3 protein results in decreased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:23034213 17alpha-ethynylestradiol decreases expression ISO RGD:735647 6480464 Ethinyl Estradiol results in decreased expression of SMAD3 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:735647 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNA CTD PMID:17942748 17beta-estradiol decreases expression ISO RGD:1343311 6480464 Estradiol results in decreased expression of SMAD3 mRNA CTD PMID:19167446 , PMID:24758408 17beta-estradiol decreases phosphorylation ISO RGD:1343311 6480464 Estradiol results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 , PMID:26407941 17beta-estradiol affects expression ISO RGD:1343311 6480464 Estradiol affects the expression of SMAD3 mRNA CTD PMID:14699072 , PMID:22574217 17beta-estradiol multiple interactions ISO RGD:1343311 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of SMAD3 mRNA more ... CTD PMID:20660070 more ... 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:1343311 6480464 Dihydrotestosterone results in increased expression of SMAD3 mRNA CTD PMID:16597033 2,3',4,4',5-Pentachlorobiphenyl affects expression ISO RGD:735647 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:735647 6480464 Tetrachlorodibenzodioxin results in increased expression of SMAD3 mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine affects phosphorylation ISO RGD:1343311 6480464 Tetrachlorodibenzodioxin affects the phosphorylation of SMAD3 protein CTD PMID:31887333 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1343311 6480464 AHR protein affects the reaction [Tetrachlorodibenzodioxin affects the phosphorylation of SMAD3 protein] CTD PMID:31887333 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:735647 6480464 Tetrachlorodibenzodioxin affects the expression of SMAD3 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:735647 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SMAD3 mRNA CTD PMID:17942748 , PMID:25975270 2-acetamidofluorene multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein, IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein] CTD PMID:15368444 2-amino-2-deoxy-D-galactopyranose multiple interactions EXP 6480464 Genistein inhibits the reaction [Galactosamine results in increased phosphorylation of SMAD3 protein] CTD PMID:27876602 2-amino-2-deoxy-D-galactopyranose increases phosphorylation EXP 6480464 Galactosamine results in increased phosphorylation of SMAD3 protein CTD PMID:27876602 2-hydroxypropanoic acid increases expression ISO RGD:1343311 6480464 Lactic Acid results in increased expression of SMAD3 mRNA CTD PMID:30851411 3,4-dihydroxybenzaldehyde multiple interactions ISO RGD:1343311 6480464 protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein], protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:17597607 3,4-methylenedioxymethamphetamine increases expression ISO RGD:735647 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of SMAD3 mRNA CTD PMID:20188158 4-hydroxyphenyl retinamide increases expression ISO RGD:735647 6480464 Fenretinide results in increased expression of SMAD3 mRNA CTD PMID:28973697 4-nonylphenol multiple interactions ISO RGD:1343311 6480464 fulvestrant inhibits the reaction [4-nonylphenol results in decreased phosphorylation of SMAD3 protein] CTD PMID:24308608 4-nonylphenol decreases phosphorylation ISO RGD:1343311 6480464 4-nonylphenol results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 4-vinylcyclohexene dioxide affects expression ISO RGD:735647 6480464 4-vinyl-1-cyclohexene dioxide affects the expression of SMAD3 mRNA CTD PMID:20829426 5-aza-2'-deoxycytidine increases expression ISO RGD:735647 6480464 Decitabine results in increased expression of SMAD3 mRNA CTD PMID:27915011 5-aza-2'-deoxycytidine multiple interactions EXP 6480464 Decitabine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:24211420 9-cis-retinoic acid multiple interactions ISO RGD:735647 6480464 [TO-901317 co-treated with Alitretinoin] results in increased expression of SMAD3 protein CTD PMID:17194744 acetaldehyde multiple interactions ISO RGD:1343311 6480464 SMAD3 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] CTD PMID:16025520 acetaldehyde increases phosphorylation ISO RGD:1343311 6480464 Acetaldehyde results in increased phosphorylation of SMAD3 protein CTD PMID:16025520 acteoside increases phosphorylation ISO RGD:1343311 6480464 acteoside results in increased phosphorylation of SMAD3 protein CTD PMID:17634406 aflatoxin B1 increases expression ISO RGD:1343311 6480464 Aflatoxin B1 results in increased expression of SMAD3 mRNA CTD PMID:21641981 , PMID:22100608 aldehydo-D-glucose multiple interactions ISO RGD:1343311 6480464 C646 compound inhibits the reaction [Glucose results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:17597607 , PMID:26045780 aldehydo-D-glucose increases phosphorylation ISO RGD:1343311 6480464 Glucose results in increased phosphorylation of SMAD3 protein CTD PMID:26045780 all-trans-retinoic acid multiple interactions ISO RGD:1343311 6480464 SMAD3 protein inhibits the reaction [Tretinoin results in decreased expression of FBN2] more ... CTD PMID:17098229 , PMID:24374174 all-trans-retinoic acid increases expression ISO RGD:1343311 6480464 Tretinoin results in increased expression of SMAD3 mRNA CTD PMID:16012519 more ... all-trans-retinoic acid decreases phosphorylation ISO RGD:1343311 6480464 Tretinoin results in decreased phosphorylation of SMAD3 protein CTD PMID:24374174 all-trans-retinoic acid decreases phosphorylation ISO RGD:735647 6480464 Tretinoin results in decreased phosphorylation of SMAD3 protein CTD PMID:16410076 all-trans-retinoic acid increases phosphorylation ISO RGD:1343311 6480464 Tretinoin results in increased phosphorylation of SMAD3 protein CTD PMID:17098229 alpha-naphthoflavone multiple interactions ISO RGD:1343311 6480464 alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein] CTD PMID:27519288 Ammothamnine multiple interactions ISO RGD:735647 6480464 oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:18395914 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of SMAD3 mRNA CTD PMID:30779732 andrographolide multiple interactions ISO RGD:735647 6480464 andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31706003 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [Diethylnitrosamine affects the phosphorylation of SMAD3 protein] CTD PMID:19418558 antirheumatic drug decreases expression ISO RGD:1343311 6480464 Antirheumatic Agents results in decreased expression of SMAD3 mRNA CTD PMID:24449571 aripiprazole multiple interactions ISO RGD:1343311 6480464 [Aripiprazole co-treated with Ozone] results in increased expression of SMAD3 mRNA CTD PMID:31476115 arsane multiple interactions EXP 6480464 Grape Seed Extract inhibits the reaction [Arsenic results in increased expression of SMAD3 protein modified form] CTD PMID:24348802 arsane increases expression EXP 6480464 Arsenic results in increased expression of SMAD3 protein modified form CTD PMID:24348802 arsenic atom multiple interactions EXP 6480464 Grape Seed Extract inhibits the reaction [Arsenic results in increased expression of SMAD3 protein modified form] CTD PMID:24348802 arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of SMAD3 protein modified form CTD PMID:24348802 arsenite(3-) multiple interactions ISO RGD:735647 6480464 arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein] more ... CTD PMID:25145660 , PMID:26354774 arsenous acid decreases expression ISO RGD:1343311 6480464 Arsenic Trioxide results in decreased expression of SMAD3 mRNA, Arsenic Trioxide results in decreased expression of SMAD3 protein CTD PMID:25196641 , PMID:25304214 arsenous acid increases expression ISO RGD:1343311 6480464 Arsenic Trioxide results in increased expression of SMAD3 mRNA CTD PMID:29633893 arsenous acid decreases response to substance ISO RGD:1343311 6480464 SMAD3 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 arsenous acid multiple interactions ISO RGD:1343311 6480464 [Arsenic Trioxide results in increased expression of MIR491 mRNA] which results in decreased expression of SMAD3 mRNA more ... CTD PMID:21649584 more ... asbestos multiple interactions ISO RGD:1343311 6480464 [Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in decreased expression of and results in increased phosphorylation of SMAD3 protein, [Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in decreased expression of SMAD3 mRNA CTD PMID:25358858 benazepril affects expression EXP 6480464 benazepril affects the expression of SMAD3 mRNA, benazepril affects the expression of SMAD3 protein CTD PMID:16635409 benazepril multiple interactions EXP 6480464 [benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein more ... CTD PMID:16635409 , PMID:19487956 benzene increases expression ISO RGD:1343311 6480464 Benzene results in increased expression of SMAD3 mRNA CTD PMID:19162166 benzo[a]pyrene increases expression ISO RGD:735647 6480464 Benzo(a)pyrene results in increased expression of SMAD3 mRNA CTD PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:1343311 6480464 Benzo(a)pyrene affects the methylation of SMAD3 promoter CTD PMID:30157460 benzo[a]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:18711122 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1343311 6480464 7 more ... CTD PMID:19150397 , PMID:20018196 benzo[b]fluoranthene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SMAD3 mRNA CTD PMID:18711122 benzo[e]pyrene increases methylation ISO RGD:1343311 6480464 benzo(e)pyrene results in increased methylation of SMAD3 intron CTD PMID:30157460 benzophenone decreases phosphorylation ISO RGD:1343311 6480464 benzophenone results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 benzophenone multiple interactions ISO RGD:1343311 6480464 fulvestrant inhibits the reaction [benzophenone results in decreased phosphorylation of SMAD3 protein] CTD PMID:24308608 betulin multiple interactions EXP 6480464 betulin inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 betulinic acid multiple interactions EXP 6480464 betulinic acid inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 bis(2-chloroethyl) sulfide decreases expression ISO RGD:735647 6480464 Mustard Gas results in decreased expression of SMAD3 mRNA CTD PMID:15674843 bisphenol A decreases phosphorylation ISO RGD:1343311 6480464 bisphenol A results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 , PMID:26407941 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SMAD3 mRNA CTD PMID:30816183 bisphenol A increases methylation ISO RGD:1343311 6480464 bisphenol A results in increased methylation of SMAD3 promoter CTD PMID:27271280 bisphenol A affects methylation ISO RGD:735647 6480464 bisphenol A affects the methylation of SMAD3 promoter CTD PMID:27334623 bisphenol A multiple interactions ISO RGD:1343311 6480464 fulvestrant inhibits the reaction [bisphenol A results in decreased phosphorylation of SMAD3 protein], Genistein inhibits the reaction [bisphenol A results in decreased phosphorylation of SMAD3 protein] CTD PMID:24308608 , PMID:26407941 bleomycin A2 multiple interactions ISO RGD:735647 6480464 2-((dimethylamino)methyl)-9-hydroxythieno(2, 3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] CTD PMID:27704718 bleomycin A2 increases expression EXP 6480464 Bleomycin results in increased expression of SMAD3 mRNA CTD PMID:26093215 bleomycin A2 multiple interactions EXP 6480464 Phytochemicals inhibits the reaction [Bleomycin results in increased expression of SMAD3 mRNA] CTD PMID:26093215 bleomycin A2 increases phosphorylation ISO RGD:735647 6480464 Bleomycin results in increased phosphorylation of SMAD3 protein CTD PMID:27704718 butan-1-ol multiple interactions ISO RGD:1343311 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SMAD3 mRNA CTD PMID:29432896 butanal decreases expression ISO RGD:1343311 6480464 butyraldehyde results in decreased expression of SMAD3 mRNA CTD PMID:26079696 cadmium atom multiple interactions ISO RGD:1343311 6480464 [Acetylcysteine co-treated with Cadmium] results in decreased expression of SMAD3 mRNA CTD PMID:29408318 cadmium dichloride multiple interactions ISO RGD:1343311 6480464 [Acetylcysteine co-treated with Cadmium Chloride co-treated with sodium arsenite] results in decreased expression of SMAD3 mRNA CTD PMID:29408318 caffeine multiple interactions ISO RGD:735647 6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 candesartan multiple interactions EXP 6480464 [benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein CTD PMID:19487956 Candesartan cilexetil multiple interactions EXP 6480464 candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD3 protein modified form] CTD PMID:27889505 cantharidin multiple interactions ISO RGD:1343311 6480464 Cantharidin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 carbamazepine affects expression ISO RGD:1343311 6480464 Carbamazepine affects the expression of SMAD3 mRNA CTD PMID:25979313 carbofuran increases expression EXP 6480464 Carbofuran results in increased expression of SMAD3 mRNA CTD PMID:28982980 carbofuran multiple interactions EXP 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD3 protein] CTD PMID:28982980 carbofuran increases phosphorylation EXP 6480464 Carbofuran results in increased phosphorylation of SMAD3 protein CTD PMID:28982980 casticin increases expression ISO RGD:1343311 6480464 casticin results in increased expression of SMAD3 mRNA CTD PMID:27862857 CGS-21680 multiple interactions EXP 6480464 8-(4-methoxyphenyl)-4-oxo-4 more ... CTD PMID:22063920 cholesterol multiple interactions ISO RGD:735647 6480464 [Cholesterol co-treated with 1, 2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of SMAD3 mRNA CTD PMID:22129739 choline multiple interactions ISO RGD:735647 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene more ... CTD PMID:20938992 , PMID:22915297 chromium(6+) decreases expression ISO RGD:1343311 6480464 chromium hexavalent ion results in decreased expression of SMAD3 mRNA CTD PMID:30690063 chrysin multiple interactions ISO RGD:735647 6480464 chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:26297989 cisplatin decreases expression ISO RGD:735647 6480464 Cisplatin results in decreased expression of SMAD3 protein CTD PMID:23628706 cisplatin increases expression ISO RGD:1343311 6480464 Cisplatin results in increased expression of SMAD3 mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:1343311 6480464 Cisplatin results in decreased expression of SMAD3 mRNA CTD PMID:19561079 cisplatin multiple interactions ISO RGD:1343311 6480464 [Cisplatin co-treated with Paclitaxel] results in decreased expression of SMAD3 mRNA CTD PMID:20705681 cocaine multiple interactions EXP 6480464 Cocaine deficiency promotes the reaction [SMARCA4 protein binds to SMAD3 protein] CTD PMID:27422367 coenzyme Q10 multiple interactions EXP 6480464 coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] CTD PMID:27174133 copper atom multiple interactions ISO RGD:1343311 6480464 [Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA CTD PMID:24690739 copper(0) multiple interactions ISO RGD:1343311 6480464 [Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA CTD PMID:24690739 copper(II) sulfate increases expression ISO RGD:1343311 6480464 Copper Sulfate results in increased expression of SMAD3 mRNA CTD PMID:19549813 corosolic acid multiple interactions ISO RGD:735647 6480464 corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of SMAD3 gene] CTD PMID:32135139 corticosterone decreases expression EXP 6480464 Corticosterone results in decreased expression of SMAD3 mRNA CTD PMID:29660438 coumestrol decreases expression ISO RGD:1343311 6480464 Coumestrol results in decreased expression of SMAD3 mRNA CTD PMID:19167446 coumestrol multiple interactions ISO RGD:1343311 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD3 mRNA CTD PMID:19167446 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter] CTD PMID:16959952 cyclosporin A increases expression ISO RGD:1343311 6480464 Cyclosporine results in increased expression of SMAD3 mRNA CTD PMID:25562108 cyclosporin A increases methylation ISO RGD:1343311 6480464 Cyclosporine results in increased methylation of SMAD3 promoter CTD PMID:27989131 cytochalasin D affects localization ISO RGD:1343311 6480464 Cytochalasin D affects the localization of SMAD3 protein CTD PMID:25756282 D-glucose multiple interactions ISO RGD:1343311 6480464 C646 compound inhibits the reaction [Glucose results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:17597607 , PMID:26045780 D-glucose increases phosphorylation ISO RGD:1343311 6480464 Glucose results in increased phosphorylation of SMAD3 protein CTD PMID:26045780 Deguelin decreases phosphorylation ISO RGD:1343311 6480464 deguelin results in decreased phosphorylation of SMAD3 protein CTD PMID:22986522 dexamethasone affects expression ISO RGD:735647 6480464 Dexamethasone affects the expression of SMAD3 mRNA CTD PMID:21277400 dexamethasone decreases expression ISO RGD:735647 6480464 Dexamethasone results in decreased expression of SMAD3 mRNA CTD PMID:29329878 diarsenic trioxide multiple interactions ISO RGD:1343311 6480464 [Arsenic Trioxide results in increased expression of MIR491 mRNA] which results in decreased expression of SMAD3 mRNA more ... CTD PMID:21649584 more ... diarsenic trioxide decreases response to substance ISO RGD:1343311 6480464 SMAD3 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 diarsenic trioxide increases expression ISO RGD:1343311 6480464 Arsenic Trioxide results in increased expression of SMAD3 mRNA CTD PMID:29633893 diarsenic trioxide decreases expression ISO RGD:1343311 6480464 Arsenic Trioxide results in decreased expression of SMAD3 mRNA, Arsenic Trioxide results in decreased expression of SMAD3 protein CTD PMID:25196641 , PMID:25304214 dibenz[a,h]anthracene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:18711122 dibenzo[a,l]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with dibenzo(a, l)pyrene] affects the expression of SMAD3 mRNA CTD PMID:18711122 dibutyl phthalate increases expression ISO RGD:735647 6480464 Dibutyl Phthalate results in increased expression of SMAD3 mRNA CTD PMID:21266533 diminazene diaceturate decreases phosphorylation ISO RGD:1343311 6480464 diminazene aceturate results in decreased phosphorylation of SMAD3 protein CTD PMID:29977014 dioxygen increases expression ISO RGD:735647 6480464 Oxygen deficiency results in increased expression of SMAD3 mRNA CTD PMID:24205000 dioxygen multiple interactions ISO RGD:1343311 6480464 Oxygen affects the reaction [AHR protein results in decreased expression of SMAD3 mRNA] CTD PMID:27103661 disodium selenite increases expression ISO RGD:1343311 6480464 Sodium Selenite results in increased expression of SMAD3 mRNA CTD PMID:18175754 disulfiram multiple interactions ISO RGD:1343311 6480464 [Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA CTD PMID:24690739 doxorubicin multiple interactions ISO RGD:1343311 6480464 Doxorubicin inhibits the reaction [TGFB1 protein results in increased localization of SMAD3 protein] CTD PMID:18606404 doxorubicin multiple interactions ISO RGD:735647 6480464 Niclosamide inhibits the reaction [Doxorubicin results in increased phosphorylation of SMAD3 protein] CTD PMID:28318631 doxorubicin increases phosphorylation ISO RGD:735647 6480464 Doxorubicin results in increased phosphorylation of SMAD3 protein CTD PMID:28318631 doxorubicin decreases expression ISO RGD:1343311 6480464 Doxorubicin results in decreased expression of SMAD3 mRNA, Doxorubicin results in decreased expression of SMAD3 protein CTD PMID:18606404 , PMID:29803840 ebselen multiple interactions ISO RGD:1343311 6480464 ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21131394 Enterolactone decreases expression ISO RGD:1343311 6480464 2, 3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of SMAD3 mRNA CTD PMID:19167446 Enterolactone multiple interactions ISO RGD:1343311 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD3 mRNA CTD PMID:19167446 ethanol multiple interactions EXP 6480464 8-(4-methoxyphenyl)-4-oxo-4 more ... CTD PMID:21172400 more ... ethanol affects splicing ISO RGD:735647 6480464 Ethanol affects the splicing of SMAD3 mRNA CTD PMID:30319688 ethanol increases expression ISO RGD:1343311 6480464 Ethanol results in increased expression of SMAD3 mRNA CTD PMID:23378141 ethanol increases expression EXP 6480464 Ethanol results in increased expression of SMAD3 protein CTD PMID:23274713 ethanol increases phosphorylation EXP 6480464 Ethanol results in increased phosphorylation of SMAD3 protein CTD PMID:21172400 , PMID:22063920 ethyl methanesulfonate increases expression ISO RGD:1343311 6480464 Ethyl Methanesulfonate results in increased expression of SMAD3 mRNA CTD PMID:23649840 fenofibrate multiple interactions ISO RGD:1343311 6480464 Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]] CTD PMID:19593819 ferulic acid multiple interactions EXP 6480464 ferulic acid inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein] CTD PMID:32278740 fipronil decreases expression EXP 6480464 fipronil results in decreased expression of SMAD3 mRNA CTD PMID:23962444 fluoranthene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of SMAD3 mRNA CTD PMID:18711122 fluoranthene multiple interactions ISO RGD:735647 6480464 [1-methylanthracene co-treated with fluoranthene] results in increased expression of SMAD3 mRNA CTD PMID:28329830 folic acid multiple interactions ISO RGD:735647 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene CTD PMID:20938992 formaldehyde increases expression ISO RGD:1343311 6480464 Formaldehyde results in increased expression of SMAD3 mRNA CTD PMID:23649840 fulvestrant multiple interactions ISO RGD:1343311 6480464 fulvestrant inhibits the reaction [4-nonylphenol results in decreased phosphorylation of SMAD3 protein] more ... CTD PMID:24308608 , PMID:26407941 galangin multiple interactions ISO RGD:1343311 6480464 LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD3 protein] CTD PMID:25268046 galangin increases phosphorylation ISO RGD:1343311 6480464 galangin results in increased phosphorylation of SMAD3 protein CTD PMID:25268046 galangin increases expression ISO RGD:1343311 6480464 galangin results in increased expression of SMAD3 mRNA CTD PMID:25268046 gallic acid multiple interactions EXP 6480464 Gallic Acid inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein] CTD PMID:32278740 genistein multiple interactions EXP 6480464 Genistein inhibits the reaction [Ethanol results in increased expression of SMAD3 protein], Genistein inhibits the reaction [Galactosamine results in increased phosphorylation of SMAD3 protein] CTD PMID:23274713 , PMID:27876602 genistein multiple interactions ISO RGD:1343311 6480464 Genistein inhibits the reaction [bisphenol A results in decreased phosphorylation of SMAD3 protein] more ... CTD PMID:26407941 genistein affects response to substance ISO RGD:1343311 6480464 SMAD3 protein affects the susceptibility to Genistein CTD PMID:22228119 genistein decreases expression ISO RGD:1343311 6480464 Genistein results in decreased expression of SMAD3 mRNA, Genistein results in decreased expression of SMAD3 protein CTD PMID:22228119 geraniol decreases expression ISO RGD:1343311 6480464 geraniol results in decreased expression of SMAD3 mRNA CTD PMID:27683099 glucose multiple interactions ISO RGD:1343311 6480464 C646 compound inhibits the reaction [Glucose results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:17597607 , PMID:26045780 glucose increases phosphorylation ISO RGD:1343311 6480464 Glucose results in increased phosphorylation of SMAD3 protein CTD PMID:26045780 hexachlorobenzene increases phosphorylation ISO RGD:735647 6480464 Hexachlorobenzene results in increased phosphorylation of SMAD3 protein CTD PMID:28923513 hexachlorobenzene multiple interactions ISO RGD:1343311 6480464 AG 1879 inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:27519288 Honokiol multiple interactions EXP 6480464 honokiol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21265825 hyaluronic acid multiple interactions ISO RGD:1343311 6480464 [4-(5-benzo(1 more ... CTD PMID:21520325 hydrogen peroxide increases secretion ISO RGD:735647 6480464 Hydrogen Peroxide results in increased secretion of SMAD3 mRNA CTD PMID:21179422 hydrogen peroxide increases phosphorylation ISO RGD:1343311 6480464 Hydrogen Peroxide results in increased phosphorylation of SMAD3 protein CTD PMID:15147944 , PMID:24762191 hydrogen peroxide multiple interactions ISO RGD:1343311 6480464 Arsenic Trioxide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:24762191 irbesartan multiple interactions EXP 6480464 [benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA, [benazepril co-treated with irbesartan] affects the expression of SMAD3 protein CTD PMID:16635409 irbesartan affects expression EXP 6480464 irbesartan affects the expression of SMAD3 mRNA, irbesartan affects the expression of SMAD3 protein CTD PMID:16635409 irinotecan decreases expression ISO RGD:1343311 6480464 Irinotecan analog results in decreased expression of SMAD3 mRNA CTD PMID:18927307 isorhamnetin multiple interactions ISO RGD:1343311 6480464 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein], NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] CTD PMID:27151496 L-methionine multiple interactions ISO RGD:735647 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene more ... CTD PMID:20938992 , PMID:22915297 lead diacetate increases methylation EXP 6480464 lead acetate results in increased methylation of SMAD3 gene CTD PMID:29571894 leptomycin B multiple interactions ISO RGD:735647 6480464 leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]] more ... CTD PMID:26354774 linoleic acid decreases abundance ISO RGD:735647 6480464 SMAD3 protein results in decreased abundance of Linoleic Acid CTD PMID:23034213 lipopolysaccharide multiple interactions ISO RGD:735647 6480464 [Lipopolysaccharides results in increased phosphorylation of SMAD3 protein] promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]] more ... CTD PMID:21295571 lipopolysaccharide increases response to substance ISO RGD:735647 6480464 SMAD3 protein results in increased susceptibility to Lipopolysaccharides CTD PMID:21131441 lipopolysaccharide increases phosphorylation ISO RGD:735647 6480464 Lipopolysaccharides results in increased phosphorylation of SMAD3 protein CTD PMID:21295571 lithocholic acid multiple interactions ISO RGD:735647 6480464 SMAD3 protein promotes the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA] more ... CTD PMID:23034213 lithocholic acid increases response to substance ISO RGD:735647 6480464 SMAD3 protein results in increased susceptibility to Lithocholic Acid CTD PMID:23034213 LY 364947 multiple interactions ISO RGD:735647 6480464 Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD3 protein modified form] CTD PMID:25566828 lycopene increases expression ISO RGD:1343311 6480464 lycopene results in increased expression of SMAD3 mRNA CTD PMID:16886892 melphalan decreases expression ISO RGD:1343311 6480464 Melphalan results in decreased expression of SMAD3 mRNA CTD PMID:22363485 menadione affects expression ISO RGD:1343311 6480464 Vitamin K 3 affects the expression of SMAD3 mRNA CTD PMID:20044591 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of SMAD3 mRNA CTD PMID:19564919 methamphetamine multiple interactions EXP 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of SMAD3 mRNA CTD PMID:19564919 methapyrilene increases methylation ISO RGD:1343311 6480464 Methapyrilene results in increased methylation of SMAD3 intron CTD PMID:30157460 Methylazoxymethanol acetate increases expression EXP 6480464 Methylazoxymethanol Acetate results in increased expression of SMAD3 mRNA CTD PMID:28349193 methylmercury chloride increases expression ISO RGD:735647 6480464 methylmercuric chloride results in increased expression of SMAD3 mRNA CTD PMID:20061341 methylmercury chloride decreases expression ISO RGD:1343311 6480464 methylmercuric chloride results in decreased expression of SMAD3 mRNA CTD PMID:28001369 methylparaben decreases expression ISO RGD:1343311 6480464 methylparaben results in decreased expression of SMAD3 mRNA CTD PMID:31745603 mirtazapine multiple interactions ISO RGD:735647 6480464 mirtazapine inhibits the reaction [Thioacetamide results in increased expression of SMAD3 protein modified form] CTD PMID:28623179 N-acetyl-L-cysteine multiple interactions ISO RGD:1343311 6480464 [Acetylcysteine co-treated with Cadmium Chloride co-treated with sodium arsenite] results in decreased expression of SMAD3 mRNA more ... CTD PMID:21131394 more ... N-nitrosodiethylamine multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein more ... CTD PMID:15368444 , PMID:19418558 N-nitrosodiethylamine affects phosphorylation EXP 6480464 Diethylnitrosamine affects the phosphorylation of SMAD3 protein CTD PMID:19418558 naringin multiple interactions EXP 6480464 naringin inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] CTD PMID:27174133 Niclosamide multiple interactions EXP 6480464 Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:28318631 Niclosamide multiple interactions ISO RGD:735647 6480464 Niclosamide inhibits the reaction [Doxorubicin results in increased phosphorylation of SMAD3 protein] CTD PMID:28318631 Niclosamide multiple interactions ISO RGD:1343311 6480464 HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] more ... CTD PMID:28318631 nicotine multiple interactions ISO RGD:735647 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 nicotine multiple interactions EXP 6480464 Nicotine results in increased expression of and results in increased phosphorylation of SMAD3 protein CTD PMID:22691361 nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of SMAD3 mRNA CTD PMID:29660438 nitric oxide multiple interactions EXP 6480464 [SMAD4 protein co-treated with SMAD3 protein] affects the susceptibility to Nitric Oxide, Nitric Oxide results in increased activity of [SMAD4 protein binds to SMAD3 protein] CTD PMID:15949472 nitrofen decreases expression ISO RGD:735647 6480464 nitrofen results in decreased expression of SMAD3 mRNA CTD PMID:12149686 Nonylphenol decreases phosphorylation ISO RGD:1343311 6480464 nonylphenol results in decreased phosphorylation of SMAD3 protein CTD PMID:26407941 Nonylphenol multiple interactions ISO RGD:1343311 6480464 fulvestrant inhibits the reaction [nonylphenol results in decreased phosphorylation of SMAD3 protein], Genistein inhibits the reaction [nonylphenol results in decreased phosphorylation of SMAD3 protein] CTD PMID:26407941 oridonin multiple interactions ISO RGD:1343311 6480464 oridonin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:30243739 osthole multiple interactions ISO RGD:1343311 6480464 [platycodin D co-treated with osthol] inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:23603464 ozone multiple interactions ISO RGD:1343311 6480464 [Aripiprazole co-treated with Ozone] results in increased expression of SMAD3 mRNA CTD PMID:31476115 ozone increases expression ISO RGD:1343311 6480464 Ozone results in increased expression of SMAD3 mRNA CTD PMID:31476115 paclitaxel multiple interactions ISO RGD:1343311 6480464 [Cisplatin co-treated with Paclitaxel] results in decreased expression of SMAD3 mRNA CTD PMID:20705681 paracetamol increases expression ISO RGD:735647 6480464 Acetaminophen results in increased expression of SMAD3 mRNA CTD PMID:11752693 paracetamol multiple interactions ISO RGD:735647 6480464 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide inhibits the reaction [Acetaminophen results in increased phosphorylation of SMAD3 protein] CTD PMID:31132129 paracetamol increases phosphorylation ISO RGD:735647 6480464 Acetaminophen results in increased phosphorylation of SMAD3 protein CTD PMID:31132129 paracetamol increases expression ISO RGD:1343311 6480464 Acetaminophen results in increased expression of SMAD3 mRNA CTD PMID:22230336 paracetamol decreases expression ISO RGD:1343311 6480464 Acetaminophen results in decreased expression of SMAD3 mRNA CTD PMID:21420995 paracetamol affects expression ISO RGD:735647 6480464 Acetaminophen affects the expression of SMAD3 mRNA CTD PMID:17562736 paraquat increases response to substance ISO RGD:735647 6480464 SMAD3 protein results in increased susceptibility to Paraquat CTD PMID:22581813 paraquat increases expression ISO RGD:1343311 6480464 Paraquat results in increased expression of SMAD3 protein modified form CTD PMID:27682480 paraquat multiple interactions ISO RGD:1343311 6480464 TGFB1 protein promotes the reaction [Paraquat results in increased expression of SMAD3 protein modified form] CTD PMID:27682480 perindopril multiple interactions EXP 6480464 Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] CTD PMID:16872305 perindopril decreases expression EXP 6480464 Perindopril results in decreased expression of SMAD3 protein CTD PMID:15619341 phenylarsine oxide multiple interactions ISO RGD:1343311 6480464 oxophenylarsine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 phenylmercury acetate multiple interactions ISO RGD:1343311 6480464 Phenylmercuric Acetate inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 phloroglucinol multiple interactions ISO RGD:1343311 6480464 Phloroglucinol analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:26054450 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:735647 6480464 corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of SMAD3 gene] CTD PMID:32135139 phorbol 13-acetate 12-myristate increases methylation ISO RGD:735647 6480464 Tetradecanoylphorbol Acetate results in increased methylation of SMAD3 gene CTD PMID:32135139 picrotoxin increases expression EXP 6480464 Picrotoxin results in increased expression of SMAD3 mRNA CTD PMID:15170462 pirinixic acid decreases expression ISO RGD:735647 6480464 pirinixic acid results in decreased expression of SMAD3 mRNA CTD PMID:20813756 platycodin D multiple interactions ISO RGD:1343311 6480464 [platycodin D co-treated with osthol] inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:23603464 potassium chromate multiple interactions ISO RGD:1343311 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD3 mRNA CTD PMID:22079256 potassium chromate decreases expression ISO RGD:1343311 6480464 potassium chromate(VI) results in decreased expression of SMAD3 mRNA CTD PMID:22079256 , PMID:22714537 progesterone multiple interactions ISO RGD:1343311 6480464 [4-(5-benzo(1 more ... CTD PMID:20660070 , PMID:21520325 progesterone decreases expression ISO RGD:1343311 6480464 Progesterone results in decreased expression of SMAD3 mRNA CTD PMID:20864642 quercetin multiple interactions ISO RGD:1343311 6480464 Quercetin inhibits the reaction [SMAD2 protein modified form binds to SMAD3 protein modified form binds to SMAD4 protein] CTD PMID:15580028 quercetin multiple interactions ISO RGD:735647 6480464 Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SMAD3 mRNA], Quercetin promotes the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21216973 , PMID:22915297 quercetin decreases expression ISO RGD:1343311 6480464 Quercetin results in decreased expression of SMAD3 protein, Quercetin results in decreased expression of SMAD3 protein modified form CTD PMID:15580028 quercitrin increases expression ISO RGD:1343311 6480464 quercitrin results in increased expression of SMAD3 mRNA CTD PMID:25193878 rac-lactic acid increases expression ISO RGD:1343311 6480464 Lactic Acid results in increased expression of SMAD3 mRNA CTD PMID:30851411 reactive oxygen species affects expression ISO RGD:1343311 6480464 Reactive Oxygen Species affects the expression of SMAD3 mRNA CTD PMID:25800948 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD3 protein] CTD PMID:21300041 resveratrol multiple interactions ISO RGD:1343311 6480464 resveratrol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:27345520 resveratrol multiple interactions ISO RGD:735647 6480464 resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of SMAD3 protein] CTD PMID:25234611 resveratrol decreases expression ISO RGD:1343311 6480464 resveratrol results in decreased expression of SMAD3 mRNA, resveratrol results in decreased expression of SMAD3 protein CTD PMID:18089832 , PMID:25721869 resveratrol decreases acetylation EXP 6480464 resveratrol results in decreased acetylation of SMAD3 protein CTD PMID:20651248 resveratrol decreases acetylation ISO RGD:735647 6480464 resveratrol results in decreased acetylation of SMAD3 protein CTD PMID:20651248 resveratrol decreases phosphorylation ISO RGD:735647 6480464 resveratrol results in decreased phosphorylation of SMAD3 protein CTD PMID:21679764 SB 203580 multiple interactions ISO RGD:1343311 6480464 SB 203580 inhibits the reaction [TGFB2 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:18253093 SB 431542 decreases phosphorylation EXP 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased phosphorylation of SMAD3 protein CTD PMID:28982980 SB 431542 multiple interactions ISO RGD:735647 6480464 4-(5-benzo(1 more ... CTD PMID:21586554 , PMID:29127033 SB 431542 multiple interactions ISO RGD:1343311 6480464 4-(5-benzo(1 more ... CTD PMID:21520325 , PMID:28871336 SB 431542 decreases phosphorylation ISO RGD:735647 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased phosphorylation of SMAD3 protein CTD PMID:29127033 SB 431542 multiple interactions EXP 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD3 protein] CTD PMID:28982980 SCH 23390 increases expression EXP 6480464 SCH 23390 results in increased expression of SMAD3 mRNA CTD PMID:19564919 SCH 23390 multiple interactions EXP 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of SMAD3 mRNA CTD PMID:19564919 serpentine asbestos multiple interactions ISO RGD:1343311 6480464 [Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in decreased expression of and results in increased phosphorylation of SMAD3 protein, [Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in decreased expression of SMAD3 mRNA CTD PMID:25358858 sevoflurane multiple interactions ISO RGD:735647 6480464 TGFB1 protein affects the reaction [sevoflurane affects the localization of SMAD3 protein] CTD PMID:18434384 sevoflurane affects response to substance ISO RGD:735647 6480464 SMAD3 protein affects the susceptibility to sevoflurane CTD PMID:18434384 silicon dioxide multiple interactions ISO RGD:1343311 6480464 NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]], tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein] CTD PMID:32097614 silicon dioxide increases phosphorylation ISO RGD:1343311 6480464 Silicon Dioxide results in increased phosphorylation of SMAD3 protein CTD PMID:32097614 silver atom increases expression ISO RGD:1343311 6480464 Silver results in increased expression of SMAD3 mRNA CTD PMID:28959546 silver(0) increases expression ISO RGD:1343311 6480464 Silver results in increased expression of SMAD3 mRNA CTD PMID:28959546 silver(1+) nitrate decreases expression ISO RGD:1343311 6480464 Silver Nitrate analog results in decreased expression of SMAD3 mRNA CTD PMID:22831968 silver(1+) nitrate increases expression ISO RGD:1343311 6480464 Silver Nitrate results in increased expression of SMAD3 mRNA CTD PMID:22831968 simvastatin increases expression ISO RGD:735647 6480464 Simvastatin results in increased expression of SMAD3 mRNA CTD PMID:18310456 simvastatin decreases phosphorylation EXP 6480464 Simvastatin results in decreased phosphorylation of SMAD3 protein CTD PMID:19659652 sodium arsenate increases expression ISO RGD:735647 6480464 sodium arsenate results in increased expression of SMAD3 mRNA CTD PMID:21795629 sodium arsenite multiple interactions ISO RGD:735647 6480464 IFNG protein inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:17003472 , PMID:23732083 sodium arsenite multiple interactions ISO RGD:1343311 6480464 [Acetylcysteine co-treated with Cadmium Chloride co-treated with sodium arsenite] results in decreased expression of SMAD3 mRNA CTD PMID:29408318 sodium arsenite increases phosphorylation EXP 6480464 sodium arsenite results in increased phosphorylation of SMAD3 protein CTD PMID:21605584 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of SMAD3 mRNA, sodium arsenite results in increased expression of SMAD3 protein modified form CTD PMID:27174133 , PMID:27889505 sodium arsenite multiple interactions EXP 6480464 candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD3 protein modified form] more ... CTD PMID:21605584 more ... sodium arsenite decreases phosphorylation ISO RGD:735647 6480464 sodium arsenite results in decreased phosphorylation of SMAD3 protein CTD PMID:23732083 sodium fluoride increases expression ISO RGD:735647 6480464 Sodium Fluoride results in increased expression of SMAD3 mRNA CTD PMID:29127033 sodium fluoride multiple interactions ISO RGD:735647 6480464 4-(5-benzo(1 more ... CTD PMID:29127033 sorafenib affects localization ISO RGD:735647 6480464 sorafenib affects the localization of SMAD3 protein CTD PMID:21360571 sorafenib multiple interactions ISO RGD:735647 6480464 sorafenib inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21360571 streptozocin multiple interactions EXP 6480464 resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD3 protein] CTD PMID:21300041 streptozocin multiple interactions ISO RGD:735647 6480464 [fatostatin co-treated with Streptozocin] results in increased phosphorylation of SMAD3 protein CTD PMID:29420703 streptozocin increases phosphorylation ISO RGD:735647 6480464 Streptozocin results in increased phosphorylation of SMAD3 protein CTD PMID:29420703 streptozocin increases phosphorylation EXP 6480464 Streptozocin results in increased phosphorylation of SMAD3 protein CTD PMID:21300041 tamoxifen multiple interactions ISO RGD:1343311 6480464 Tamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD3 protein] CTD PMID:17098229 tamoxifen multiple interactions ISO RGD:735647 6480464 [Tamoxifen co-treated with Zearalenone] results in increased expression of SMAD3 mRNA CTD PMID:30138655 tamoxifen increases phosphorylation ISO RGD:1343311 6480464 Tamoxifen results in increased phosphorylation of SMAD3 protein CTD PMID:17098229 Tanshinone I multiple interactions ISO RGD:1343311 6480464 NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]], tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein] CTD PMID:32097614 tauro-beta-muricholic acid increases abundance ISO RGD:735647 6480464 SMAD3 protein results in increased abundance of tauromuricholic acid CTD PMID:23034213 taurochenodeoxycholic acid increases abundance ISO RGD:735647 6480464 SMAD3 protein results in increased abundance of Taurochenodeoxycholic Acid CTD PMID:23034213 taurolithocholic acid increases abundance ISO RGD:735647 6480464 SMAD3 protein results in increased abundance of Taurolithocholic Acid CTD PMID:23034213 tauroursodeoxycholic acid increases abundance ISO RGD:735647 6480464 SMAD3 protein results in increased abundance of tauroursodeoxycholic acid CTD PMID:23034213 tert-butyl hydroperoxide increases expression ISO RGD:1343311 6480464 tert-Butylhydroperoxide results in increased expression of SMAD3 mRNA CTD PMID:27509014 tert-butyl hydroperoxide increases methylation ISO RGD:1343311 6480464 tert-Butylhydroperoxide results in increased methylation of SMAD3 gene CTD PMID:27509014 Tesaglitazar decreases expression EXP 6480464 tesaglitazar results in decreased expression of SMAD3 mRNA CTD PMID:21515302 testosterone increases expression ISO RGD:735647 6480464 Testosterone results in increased expression of SMAD3 mRNA CTD PMID:22138414 tetrachloromethane increases phosphorylation EXP 6480464 Carbon Tetrachloride results in increased phosphorylation of SMAD3 protein CTD PMID:24211420 , PMID:25150141 tetrachloromethane increases expression ISO RGD:735647 6480464 Carbon Tetrachloride results in increased expression of SMAD3 mRNA CTD PMID:18395914 , PMID:26297989 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of SMAD3 mRNA, Carbon Tetrachloride results in increased expression of SMAD3 protein CTD PMID:15818738 more ... tetrachloromethane multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased phosphorylation of SMAD3 protein more ... CTD PMID:15818738 more ... tetrachloromethane increases activity EXP 6480464 Carbon Tetrachloride results in increased activity of SMAD3 protein CTD PMID:17009398 tetrachloromethane affects response to substance ISO RGD:735647 6480464 SMAD3 protein affects the susceptibility to Carbon Tetrachloride CTD PMID:16382155 tetrachloromethane multiple interactions ISO RGD:735647 6480464 Carbon Tetrachloride inhibits the reaction [HGF protein affects the localization of SMAD3 protein] more ... CTD PMID:18395096 more ... thioacetamide multiple interactions ISO RGD:735647 6480464 mirtazapine inhibits the reaction [Thioacetamide results in increased expression of SMAD3 protein modified form] CTD PMID:28623179 thioacetamide increases phosphorylation EXP 6480464 Thioacetamide results in increased phosphorylation of SMAD3 protein CTD PMID:32278740 thioacetamide multiple interactions EXP 6480464 ferulic acid inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:32278740 thioacetamide increases expression ISO RGD:735647 6480464 Thioacetamide results in increased expression of SMAD3 protein modified form CTD PMID:28623179 trichostatin A affects expression ISO RGD:1343311 6480464 trichostatin A affects the expression of SMAD3 mRNA CTD PMID:28542535 troglitazone multiple interactions ISO RGD:1343311 6480464 troglitazone inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:18253093 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of SMAD3 mRNA CTD PMID:21515302 tungsten decreases expression ISO RGD:735647 6480464 Tungsten results in decreased expression of SMAD3 mRNA CTD PMID:30912803 ursodeoxycholic acid decreases expression EXP 6480464 Ursodeoxycholic Acid results in decreased expression of SMAD3 mRNA, Ursodeoxycholic Acid results in decreased expression of SMAD3 protein CTD PMID:19493473 valproic acid increases methylation ISO RGD:1343311 6480464 Valproic Acid results in increased methylation of SMAD3 gene CTD PMID:28853863 more ... valproic acid decreases expression ISO RGD:1343311 6480464 Valproic Acid results in decreased expression of SMAD3 mRNA, Valproic Acid results in decreased expression of SMAD3 protein CTD PMID:29501571 valsartan multiple interactions EXP 6480464 Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] CTD PMID:16872305 valsartan decreases expression EXP 6480464 Valsartan results in decreased expression of SMAD3 protein CTD PMID:15619341 vitamin E increases expression ISO RGD:1343311 6480464 Vitamin E results in increased expression of SMAD3 mRNA CTD PMID:19244175 zearalenone multiple interactions ISO RGD:735647 6480464 [Tamoxifen co-treated with Zearalenone] results in increased expression of SMAD3 mRNA CTD PMID:30138655 zearalenone increases expression ISO RGD:735647 6480464 Zearalenone results in increased expression of SMAD3 mRNA CTD PMID:30138655 zinc atom multiple interactions ISO RGD:735647 6480464 Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]] more ... CTD PMID:22228435 , PMID:26354774 zinc(0) multiple interactions ISO RGD:735647 6480464 Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]] more ... CTD PMID:22228435 , PMID:26354774 ziram multiple interactions ISO RGD:1343311 6480464 Ziram inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 zoledronic acid increases expression ISO RGD:1343311 6480464 zoledronic acid results in increased expression of SMAD3 mRNA CTD PMID:24714768 zoledronic acid increases phosphorylation ISO RGD:1343311 6480464 zoledronic acid results in increased phosphorylation of SMAD3 protein CTD PMID:28871336 zoledronic acid increases phosphorylation ISO RGD:735647 6480464 zoledronic acid results in increased phosphorylation of SMAD3 protein CTD PMID:28871336 zoledronic acid multiple interactions ISO RGD:1343311 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [zoledronic acid results in increased phosphorylation of SMAD3 protein] CTD PMID:28871336 zoledronic acid increases phosphorylation EXP 6480464 zoledronic acid results in increased phosphorylation of SMAD3 protein CTD PMID:28871336
Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process ISO RGD:1343311 1624291 (PMID:15107418) RGD PMID:15107418 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP 2301029 TGF-beta1-induced cleavage of BAD to its more active 15 kD form RGD activin receptor signaling pathway ISO RGD:1343311 1624291 (PMID:15150278) RGD PMID:15150278 adrenal gland development IDA 728125 RGD cell cycle arrest ISO RGD:1343311 1624291 (PMID:14555988) RGD PMID:14555988 cell-cell junction organization ISO RGD:1343311 1624291 (PMID:18505915) RGD PMID:18505915 cellular response to transforming growth factor beta stimulus ISO RGD:1343311 1624291 (PMID:12902338) RGD PMID:12902338 developmental growth ISO RGD:735647 1624291 MGI:MGI:108051 (MGI:MGI:3618021 , PMID:15183723) RGD MGI:MGI:3618021 , PMID:15183723 embryonic cranial skeleton morphogenesis ISO RGD:735647 1624291 MGI:MGI:108051 (MGI:MGI:3618021 , PMID:15183723) RGD MGI:MGI:3618021 , PMID:15183723 embryonic foregut morphogenesis ISO RGD:735647 1624291 MGI:MGI:108051 (MGI:MGI:3618021 , PMID:15183723) RGD MGI:MGI:3618021 , PMID:15183723 embryonic pattern specification ISO RGD:735647 1624291 MGI:MGI:108051 (MGI:MGI:3618021 , PMID:15183723) RGD MGI:MGI:3618021 , PMID:15183723 endoderm development ISO RGD:735647 1624291 MGI:MGI:108051 (MGI:MGI:3618021 , PMID:15183723) RGD MGI:MGI:3618021 , PMID:15183723 extrinsic apoptotic signaling pathway ISO RGD:1343311 1624291 (PMID:15334054) RGD PMID:15334054 gastrulation ISO RGD:735647 1624291 MGI:MGI:108051 (MGI:MGI:3618021 , PMID:15183723) RGD MGI:MGI:3618021 , PMID:15183723 heart looping ISO RGD:735647 1624291 MGI:MGI:108051 (MGI:MGI:3618021 , PMID:15183723) RGD MGI:MGI:3618021 , PMID:15183723 immune response ISO RGD:1343311 1624291 (PMID:16886151) RGD PMID:16886151 immune system development ISO RGD:735647 1624291 MGI:MGI:108051 (MGI:MGI:3618021 , PMID:15183723) RGD MGI:MGI:3618021 , PMID:15183723 in utero embryonic development ISO RGD:735647 1624291 MGI:MGI:108051 (MGI:MGI:3618021 , PMID:15183723) RGD MGI:MGI:3618021 , PMID:15183723 lens fiber cell differentiation ISO RGD:735647 1624291 (MGI:MGI:3720408, PMID:17215516) RGD MGI:MGI:3720408 , PMID:17215516 liver development ISO RGD:735647 1624291 MGI:MGI:108051 (MGI:MGI:3618021 , PMID:15183723) RGD MGI:MGI:3618021 , PMID:15183723 mesoderm formation ISO RGD:735647 1624291 MGI:MGI:1857696 (MGI:MGI:3039049 , PMID:15084457) RGD MGI:MGI:3039049 , PMID:15084457 negative regulation of apoptotic process IDA 2300426 osteoblastic UMR-106 cells RGD negative regulation of cardiac muscle hypertrophy in response to stress IGI RNAcentral:URS0000554A4F_10116 11535100 PMID:27038547 BHF-UCL negative regulation of cell growth ISO RGD:1343311 1624291 (PMID:8774881) RGD PMID:8774881 negative regulation of cell population proliferation IDA 2300418 RGD negative regulation of cytosolic calcium ion concentration ISO RGD:1343311 1624291 (PMID:27038547) RGD PMID:27038547 negative regulation of fat cell differentiation ISO RGD:1343311 1624291 (PMID:19816956) RGD PMID:19816956 negative regulation of inflammatory response ISO RGD:735647 1624291 (MGI:MGI:1352043, PMID:10559937) RGD MGI:MGI:1352043 , PMID:10559937 negative regulation of lung blood pressure IGI RNAcentral:URS0000554A4F_10116 11535100 PMID:27038547 BHF-UCL negative regulation of mitotic cell cycle ISO RGD:1343311 1624291 (PMID:14555988) RGD PMID:14555988 negative regulation of osteoblast differentiation ISO RGD:735647 1624291 MGI:MGI:1316736 (MGI:MGI:3056877 , PMID:15150273) RGD MGI:MGI:3056877 , PMID:15150273 negative regulation of osteoblast proliferation ISO RGD:735647 1624291 (MGI:MGI:5285145, PMID:21035443) RGD MGI:MGI:5285145 , PMID:21035443 negative regulation of protein catabolic process IMP 11079190 PMID:20097766 BHF-UCL negative regulation of protein catabolic process IDA 15023472 PMID:16690606 CACAO negative regulation of transcription by RNA polymerase II IMP 2300406 rat Tert gene RGD negative regulation of transcription by RNA polymerase II ISO RGD:735647 1624291 (MGI:MGI:1276222 more ... RGD MGI:MGI:1276222 more ... negative regulation of transcription by RNA polymerase II ISO RGD:1343311 1624291 (PMID:14555988), (PMID:8774881) RGD PMID:14555988 , PMID:8774881 negative regulation of wound healing ISO RGD:735647 1624291 (MGI:MGI:1352043 more ... RGD MGI:MGI:1352043 more ... nodal signaling pathway ISO RGD:1343311 1624291 (PMID:15150278) RGD PMID:15150278 osteoblast development ISO RGD:735647 1624291 MGI:MGI:1316736 (MGI:MGI:3056877 , PMID:15150273) RGD MGI:MGI:3056877 , PMID:15150273 osteoblast differentiation ISO RGD:735647 1624291 (MGI:MGI:3654245, PMID:11585338) RGD MGI:MGI:3654245 , PMID:11585338 paraxial mesoderm morphogenesis ISO RGD:735647 1624291 MGI:MGI:1857696 (MGI:MGI:3039049 , PMID:15084457) RGD MGI:MGI:3039049 , PMID:15084457 pericardium development ISO RGD:735647 1624291 MGI:MGI:108051 (MGI:MGI:3618021 , PMID:15183723) RGD MGI:MGI:3618021 , PMID:15183723 positive regulation of alkaline phosphatase activity IDA 727387 rat gene expressed in mouse osteoblastic cell line MC3T3-E1, TGF-beta down-regulates this activity RGD positive regulation of bone mineralization IDA 727387 rat gene expressed in mouse osteoblastic cell line MC3T3-E1, TGF-beta down-regulates this activity RGD positive regulation of canonical Wnt signaling pathway IMP 11079190 PMID:20097766 BHF-UCL positive regulation of cell migration IMP 2300403 transformed cells in culture RGD positive regulation of chondrocyte differentiation ISO RGD:735647 1624291 (MGI:MGI:5285145, PMID:21035443) RGD MGI:MGI:5285145 , PMID:21035443 positive regulation of epithelial to mesenchymal transition ISO RGD:1343311 1624291 (PMID:18505915), (PMID:21307346) RGD PMID:18505915 , PMID:21307346 positive regulation of extracellular matrix assembly ISO RGD:1343311 1624291 (PMID:21307346) RGD PMID:21307346 positive regulation of focal adhesion assembly IDA 2300418 RGD positive regulation of gene expression ISO RGD:1343311 1624291 (PMID:21307346) RGD PMID:21307346 positive regulation of interleukin-1 beta production IMP 2300404 TGFbeta-1 dependent, in pancreatic stellate cells RGD positive regulation of nitric oxide biosynthetic process IGI RNAcentral:URS0000554A4F_10116 11535100 PMID:27038547 BHF-UCL positive regulation of nitric oxide biosynthetic process ISO RGD:1343311 1624291 (PMID:27038547) RGD PMID:27038547 positive regulation of positive chemotaxis IDA 2300418 Hepatic stellate cells, toward serum and type I collagen RGD positive regulation of pri-miRNA transcription by RNA polymerase II ISO RGD:1343311 1624291 (PMID:26311719) RGD PMID:26311719 positive regulation of stress fiber assembly IDA 2300418 during transdifferentiation RGD positive regulation of transcription by RNA polymerase II IDA 1299323 alpha-smooth muscle actin in lung fibroblasts RGD positive regulation of transcription by RNA polymerase II ISO RGD:735647 1624291 MGI:MGI:106658 more ... RGD MGI:MGI:2675699 more ... positive regulation of transcription by RNA polymerase II ISO RGD:1343311 1624291 (PMID:14555988), (PMID:18832382), (PMID:8774881) RGD PMID:14555988 more ... positive regulation of transcription by RNA polymerase II IMP 8554355 PMID:22073128 BHF-UCL positive regulation of transcription by RNA polymerase II IMP 1625706 RGD positive regulation of transcription, DNA-templated ISO RGD:735647 1624291 (MGI:MGI:3056014 more ... RGD MGI:MGI:3056014 more ... positive regulation of transcription, DNA-templated ISO RGD:1343311 1624291 (PMID:9111321), (PMID:9311995), (PMID:9732876) RGD PMID:9111321 more ... positive regulation of transforming growth factor beta3 production IMP 1625706 RGD protein stabilization IMP 11079190 PMID:20097766 BHF-UCL regulation of binding ISO RGD:735647 1624291 (MGI:MGI:3513643, PMID:15282343) RGD MGI:MGI:3513643 , PMID:15282343 regulation of epithelial cell proliferation ISO RGD:735647 1624291 MGI:MGI:1857695 (MGI:MGI:3617027 , PMID:12845704) RGD MGI:MGI:3617027 , PMID:12845704 regulation of immune response ISO RGD:735647 1624291 (MGI:MGI:1332876, PMID:10064594) RGD MGI:MGI:1332876 , PMID:10064594 regulation of striated muscle tissue development ISO RGD:735647 1624291 (MGI:MGI:2153314, PMID:11711431) RGD MGI:MGI:2153314 , PMID:11711431 regulation of transcription by RNA polymerase II ISO RGD:1343311 1624291 (PMID:21947082) RGD PMID:21947082 regulation of transforming growth factor beta receptor signaling pathway ISO RGD:735647 1624291 (MGI:MGI:2153314, PMID:11711431) RGD MGI:MGI:2153314 , PMID:11711431 regulation of transforming growth factor beta receptor signaling pathway ISO RGD:1343311 1624291 (PMID:8774881) RGD PMID:8774881 regulation of transforming growth factor beta2 production ISO RGD:1343311 1624291 (PMID:12411310) RGD PMID:12411310 response to hypoxia ISO RGD:1343311 1624291 (PMID:12411310) RGD PMID:12411310 signal transduction involved in regulation of gene expression IMP 8554355 PMID:22073128 BHF-UCL skeletal system development ISO RGD:735647 1624291 MGI:MGI:108051 (MGI:MGI:3618021 , PMID:15183723) RGD MGI:MGI:3618021 , PMID:15183723 SMAD protein complex assembly IPI RGD:3033 , RGD:2401 1599906 RGD SMAD protein complex assembly ISO RGD:1343311 1624291 (PMID:10823886), (PMID:9111321) RGD PMID:10823886 , PMID:9111321 SMAD protein signal transduction ISO RGD:735647 1624291 MGI:MGI:108051 (MGI:MGI:5486383 , PMID:23390484) RGD MGI:MGI:5486383 , PMID:23390484 somitogenesis ISO RGD:735647 1624291 MGI:MGI:108051 (MGI:MGI:3618021 , PMID:15183723) RGD MGI:MGI:3618021 , PMID:15183723 T cell activation ISO RGD:735647 1624291 (MGI:MGI:1332876, PMID:10064594) RGD MGI:MGI:1332876 , PMID:10064594 thyroid gland development ISO RGD:735647 1624291 MGI:MGI:108051 (MGI:MGI:3618021 , PMID:15183723) RGD MGI:MGI:3618021 , PMID:15183723 transdifferentiation IDA 2300418 quiescent hepatic stellate cells to myofibroblasts RGD transforming growth factor beta receptor signaling pathway IMP 1625706 RGD transforming growth factor beta receptor signaling pathway ISO RGD:1343311 1624291 (PMID:18548003), (PMID:21947082), (PMID:9732876) RGD PMID:18548003 more ... transforming growth factor beta receptor signaling pathway ISO RGD:735647 1624291 (MGI:MGI:3505646 more ... RGD MGI:MGI:3505646 more ... transforming growth factor beta receptor signaling pathway IMP 8554355 PMID:22073128 BHF-UCL transforming growth factor beta receptor signaling pathway IMP 2300404 TGFbeta-1 dependent, in pancreatic stellate cells RGD ureteric bud development ISO RGD:735647 1624291 (PMID:14656760) RGD PMID:14656760 Cellular Component cytoplasm IDA 2300403 RGD cytoplasm ISO RGD:735647 1624291 (MGI:MGI:5009194, PMID:11160896) RGD MGI:MGI:5009194 , PMID:11160896 cytoplasm ISO RGD:1343311 1624291 (PMID:12446380), (PMID:21947082), (PMID:9311995) RGD PMID:12446380 more ... cytosol IEA UniProtKB:A0A024R5Z3 , ensembl:ENSP000003329731600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:1343311 1624291 RGD GO_REF:0000052 cytosol IEA UniProtKB:P84022 , ensembl:ENSP000003329731600115 GO_REF:0000107 Ensembl GO_REF:0000107 heteromeric SMAD protein complex ISO RGD:1343311 1624291 (PMID:21828274) RGD PMID:21828274 nuclear chromatin ISO RGD:1343311 1624291 (PMID:21828274) RGD PMID:21828274 nuclear inner membrane ISO RGD:1343311 1624291 (PMID:15647271) RGD PMID:15647271 nucleoplasm ISO RGD:1343311 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:P84022 , ensembl:ENSP000003329731600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm IEA UniProtKB:A0A024R5Z3 , ensembl:ENSP000003329731600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus IDA 1599906 ; 2300403 RGD nucleus IDA 15023472 PMID:16690606 CACAO nucleus IDA 11079190 PMID:20097766 CACAO nucleus ISO RGD:735647 1624291 (MGI:MGI:2675699 more ... RGD MGI:MGI:2675699 more ... nucleus ISO RGD:1343311 1624291 (PMID:12446380), (PMID:16007207), (PMID:21947082), (PMID:25893292), (PMID:9311995) RGD PMID:12446380 more ... nucleus IDA 8554355 PMID:22073128 BHF-UCL plasma membrane ISO RGD:735647 1624291 (MGI:MGI:2449899, PMID:12543979) RGD MGI:MGI:2449899 , PMID:12543979 protein-containing complex IDA 1599906 RGD receptor complex ISO RGD:1343311 1624291 (PMID:8774881) RGD PMID:8774881 SMAD protein complex ISO RGD:1343311 1624291 (PMID:18832382), (PMID:21947082) RGD PMID:18832382 , PMID:21947082 SMAD protein complex ISS UniProtKB:P84022 1600115 GO_REF:0000024 UniProt GO_REF:0000024 transcription regulator complex IDA 1625706 RGD transcription regulator complex ISO RGD:1343311 1624291 (PMID:21947082) RGD PMID:21947082 Molecular Function beta-catenin binding IDA 11079190 PMID:20097766 BHF-UCL bHLH transcription factor binding ISO RGD:1343311 1624291 UniProtKB:Q99081 (PMID:21828274) RGD PMID:21828274 chromatin binding ISO RGD:735647 1624291 (MGI:MGI:3690196, PMID:16619037) RGD MGI:MGI:3690196 , PMID:16619037 chromatin DNA binding ISO RGD:735647 1624291 (MGI:MGI:3696631, PMID:16224064) RGD MGI:MGI:3696631 , PMID:16224064 cis-regulatory region sequence-specific DNA binding ISO RGD:1343311 1624291 (PMID:21947082) RGD PMID:21947082 cis-regulatory region sequence-specific DNA binding ISS UniProtKB:P84022 1600115 GO_REF:0000024 UniProt GO_REF:0000024 co-SMAD binding ISO RGD:1343311 1624291 UniProtKB:Q13485 (PMID:8774881), (PMID:9111321), (PMID:9311995), (PMID:9732876) RGD PMID:8774881 more ... collagen binding ISO RGD:735647 1624291 PR:P08121 more ... RGD MGI:MGI:2679769 , PMID:14559231 DEAD/H-box RNA helicase binding ISO RGD:1343311 1624291 UniProtKB:P17844 (PMID:18548003) RGD PMID:18548003 DNA binding IDA 1599906 RGD DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:1343311 1624291 (PMID:26311719) RGD PMID:26311719 DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:735647 1624291 ENSEMBL_GeneID:ENSG00000127445 (MGI:MGI:6158712, PMID:24964035) RGD MGI:MGI:6158712 , PMID:24964035 DNA-binding transcription factor activity IDA 1299323 RGD DNA-binding transcription factor activity ISO RGD:1343311 1624291 (PMID:10823886), (PMID:21947082), (PMID:9732876) RGD PMID:10823886 more ... DNA-binding transcription factor activity contributes_to ISO RGD:1343311 1624291 (PMID:9111321) RGD PMID:9111321 DNA-binding transcription factor activity ISO RGD:735647 1624291 (MGI:MGI:2675699, PMID:12943993) RGD MGI:MGI:2675699 , PMID:12943993 DNA-binding transcription factor activity, RNA polymerase II-specific ISO RGD:1343311 1624291 (PMID:21947082) RGD PMID:21947082 double-stranded DNA binding ISO RGD:735647 1624291 (MGI:MGI:3513643, PMID:15282343) RGD MGI:MGI:3513643 , PMID:15282343 enzyme binding IPI RGD:2053 8554355 RGD enzyme binding IPI UniProtKB:P27008 8554355 PMID:22073128 BHF-UCL glucocorticoid receptor binding ISO RGD:1343311 1624291 UniProtKB:P04150 (PMID:12902338) RGD PMID:12902338 identical protein binding ISO RGD:1343311 1624291 UniProtKB:P84022 (PMID:18729074), (PMID:22045334) RGD PMID:18729074 , PMID:22045334 identical protein binding ISO RGD:735647 1624291 (MGI:MGI:5317378, PMID:21724602) RGD MGI:MGI:5317378 , PMID:21724602 mineralocorticoid receptor binding ISO RGD:1343311 1624291 UniProtKB:P22199 (PMID:12902338) RGD PMID:12902338 phosphatase binding ISO RGD:1343311 1624291 UniProtKB:P35813 (PMID:16751101) RGD PMID:16751101 protein binding IPI RGD:2401 1599906 RGD protein binding ISO RGD:735647 1624291 MGI:MGI:98388 more ... RGD MGI:MGI:2153314 more ... protein binding ISO RGD:1343311 1624291 UniProtKB:E9PSE9 more ... RGD PMID:10681527 more ... protein binding IPI UniProtKB:P47196 8553856 PMID:16362038 IntAct protein binding IPI UniProtKB:O35740 8554622 PMID:16619037 UniProt protein homodimerization activity ISO RGD:1343311 1624291 UniProtKB:P84022 (PMID:8774881) RGD PMID:8774881 protein kinase binding ISO RGD:1343311 1624291 UniProtKB:Q9H2X6 (PMID:12874272) RGD PMID:12874272 R-SMAD binding ISO RGD:1343311 1624291 UniProtKB:P84022 , UniProtKB:Q15796 (PMID:20129061), (PMID:9311995) RGD PMID:20129061 , PMID:9311995 RNA polymerase II activating transcription factor binding ISO RGD:1343311 1624291 UniProtKB:P26367 (PMID:17251190) RGD PMID:17251190 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:1343311 1624291 (PMID:18832382), (PMID:21947082), (PMID:31582430) RGD PMID:18832382 more ... RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO RGD:735647 1624291 (MGI:MGI:5688819, PMID:25065622) RGD MGI:MGI:5688819 , PMID:25065622 sequence-specific DNA binding IDA 1299323 Smad binding elements SBE1 and SBE2 in alpha-smooth muscle actin promoter RGD sequence-specific DNA binding ISO RGD:1343311 1624291 (PMID:10823886) RGD PMID:10823886 sequence-specific DNA binding IDA 8554355 PMID:22073128 BHF-UCL sequence-specific DNA binding IDA 2300406 Smad binding element (SBE) in the rat Tert gene promoter RGD sequence-specific DNA binding IDA 1625706 RGD SMAD binding IPI RGD:3033 1599906 RGD transcription coactivator binding ISO RGD:1343311 1624291 UniProtKB:Q9ULJ6 (PMID:16777850) RGD PMID:16777850 transcription factor binding IPI RGD:620036 2301880 RGD transcription factor binding ISO RGD:735647 1624291 UniProtKB:B7ZQJ9 (MGI:MGI:4399035 , PMID:11937490) RGD MGI:MGI:4399035 , PMID:11937490 transcription factor binding ISO RGD:1343311 1624291 UniProtKB:O75593 more ... RGD PMID:21828274 , PMID:9732876 transcription factor binding IDA 2300420 recombinant Klf4, unknown species RGD transcription regulatory region sequence-specific DNA binding ISO RGD:1343311 1624291 (PMID:9732876) RGD PMID:9732876 transforming growth factor beta receptor binding ISO RGD:1343311 1624291 UniProtKB:P36897 (PMID:9311995) RGD PMID:9311995 ubiquitin binding ISO RGD:1343311 1624291 (PMID:18794808) RGD PMID:18794808 ubiquitin protein ligase binding ISO RGD:1343311 1624291 UniProtKB:Q9HAU4 , UniProtKB:Q9HCE7 (PMID:11278251), (PMID:19122240) RGD PMID:11278251 , PMID:19122240 zinc ion binding ISO RGD:1343311 1624291 (PMID:12686552) RGD PMID:12686552
Gene-Chemical Interaction Annotations
