(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1343311 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD3 mRNA CTD PMID:22079256 (-)-epigallocatechin 3-gallate decreases expression ISO RGD:735647 6480464 epigallocatechin gallate results in decreased expression of SMAD3 protein CTD PMID:34600025 (R)-lipoic acid multiple interactions ISO RGD:735647 6480464 Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] CTD PMID:35187969 (S)-nicotine multiple interactions ISO RGD:735647 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 (S)-nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of SMAD3 mRNA CTD PMID:29660438 (S)-nicotine multiple interactions EXP 6480464 Nicotine results in increased expression of and results in increased phosphorylation of SMAD3 protein CTD PMID:22691361 1,2-dimethylhydrazine increases expression ISO RGD:735647 6480464 1, 2-Dimethylhydrazine results in increased expression of SMAD3 mRNA CTD PMID:22206623 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression ISO RGD:735647 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO RGD:735647 6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 1-O-oleoyl-sn-glycero-3-phosphocholine decreases abundance ISO RGD:735647 6480464 SMAD3 protein results in decreased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:23034213 17alpha-ethynylestradiol decreases expression ISO RGD:735647 6480464 Ethinyl Estradiol results in decreased expression of SMAD3 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:735647 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNA CTD PMID:17942748 17beta-estradiol decreases expression ISO RGD:1343311 6480464 Estradiol results in decreased expression of SMAD3 mRNA CTD PMID:19167446 , PMID:24758408 17beta-estradiol decreases phosphorylation ISO RGD:1343311 6480464 Estradiol results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 , PMID:26407941 17beta-estradiol affects expression ISO RGD:1343311 6480464 Estradiol affects the expression of SMAD3 mRNA CTD PMID:14699072 , PMID:22574217 17beta-estradiol multiple interactions ISO RGD:1343311 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of SMAD3 mRNA more ... CTD PMID:20660070 more ... 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:1343311 6480464 Dihydrotestosterone results in increased expression of SMAD3 mRNA CTD PMID:16597033 2,3',4,4',5-Pentachlorobiphenyl affects expression ISO RGD:735647 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:735647 6480464 Tetrachlorodibenzodioxin results in increased expression of SMAD3 mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SMAD3 mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine affects phosphorylation ISO RGD:1343311 6480464 Tetrachlorodibenzodioxin affects the phosphorylation of SMAD3 protein CTD PMID:31887333 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1343311 6480464 AHR protein affects the reaction [Tetrachlorodibenzodioxin affects the phosphorylation of SMAD3 protein] CTD PMID:31887333 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:735647 6480464 Tetrachlorodibenzodioxin affects the expression of SMAD3 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:735647 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SMAD3 mRNA CTD PMID:17942748 , PMID:25975270 2-acetamidofluorene multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein, IFNA2 protein promotes the reaction [[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein] CTD PMID:15368444 2-amino-2-deoxy-D-galactopyranose multiple interactions EXP 6480464 Genistein inhibits the reaction [Galactosamine results in increased phosphorylation of SMAD3 protein] CTD PMID:27876602 2-amino-2-deoxy-D-galactopyranose increases phosphorylation EXP 6480464 Galactosamine results in increased phosphorylation of SMAD3 protein CTD PMID:27876602 2-hydroxypropanoic acid increases expression ISO RGD:1343311 6480464 Lactic Acid results in increased expression of SMAD3 mRNA CTD PMID:30851411 3,4-dihydroxybenzaldehyde multiple interactions ISO RGD:1343311 6480464 protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein], protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:17597607 3,4-methylenedioxymethamphetamine increases expression ISO RGD:735647 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of SMAD3 mRNA CTD PMID:20188158 4-hydroxyphenyl retinamide increases expression ISO RGD:735647 6480464 Fenretinide results in increased expression of SMAD3 mRNA CTD PMID:28973697 4-nonylphenol multiple interactions ISO RGD:1343311 6480464 fulvestrant inhibits the reaction [4-nonylphenol results in decreased phosphorylation of SMAD3 protein] CTD PMID:24308608 4-nonylphenol decreases phosphorylation ISO RGD:1343311 6480464 4-nonylphenol results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 4-vinylcyclohexene dioxide affects expression ISO RGD:735647 6480464 4-vinyl-1-cyclohexene dioxide affects the expression of SMAD3 mRNA CTD PMID:20829426 5-aza-2'-deoxycytidine increases expression ISO RGD:735647 6480464 Decitabine results in increased expression of SMAD3 mRNA CTD PMID:27915011 5-aza-2'-deoxycytidine multiple interactions EXP 6480464 Decitabine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:24211420 9-cis-retinoic acid multiple interactions ISO RGD:735647 6480464 [T0901317 co-treated with Alitretinoin] results in increased expression of SMAD3 protein CTD PMID:17194744 acetaldehyde multiple interactions ISO RGD:1343311 6480464 SMAD3 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] CTD PMID:16025520 acetaldehyde increases phosphorylation ISO RGD:1343311 6480464 Acetaldehyde results in increased phosphorylation of SMAD3 protein CTD PMID:16025520 acteoside increases phosphorylation ISO RGD:1343311 6480464 acteoside results in increased phosphorylation of SMAD3 protein CTD PMID:17634406 aflatoxin B1 increases expression ISO RGD:1343311 6480464 Aflatoxin B1 results in increased expression of SMAD3 mRNA CTD PMID:21641981 , PMID:22100608 aldehydo-D-glucose multiple interactions ISO RGD:1343311 6480464 4-(4-((5-(4 more ... CTD PMID:17597607 , PMID:26045780 aldehydo-D-glucose increases phosphorylation ISO RGD:1343311 6480464 Glucose results in increased phosphorylation of SMAD3 protein CTD PMID:26045780 all-trans-retinoic acid multiple interactions ISO RGD:1343311 6480464 SMAD3 protein inhibits the reaction [Tretinoin results in decreased expression of FBN2] more ... CTD PMID:17098229 , PMID:24374174 all-trans-retinoic acid increases expression ISO RGD:1343311 6480464 Tretinoin results in increased expression of SMAD3 mRNA CTD PMID:16012519 more ... all-trans-retinoic acid decreases phosphorylation ISO RGD:1343311 6480464 Tretinoin results in decreased phosphorylation of SMAD3 protein CTD PMID:24374174 all-trans-retinoic acid decreases phosphorylation ISO RGD:735647 6480464 Tretinoin results in decreased phosphorylation of SMAD3 protein CTD PMID:16410076 all-trans-retinoic acid increases phosphorylation ISO RGD:1343311 6480464 Tretinoin results in increased phosphorylation of SMAD3 protein CTD PMID:17098229 alpha-naphthoflavone multiple interactions ISO RGD:1343311 6480464 alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein] CTD PMID:27519288 AM-251 multiple interactions ISO RGD:1343311 6480464 AM 251 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:27936102 Ammothamnine multiple interactions ISO RGD:735647 6480464 oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:18395914 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of SMAD3 mRNA CTD PMID:30779732 andrographolide multiple interactions ISO RGD:735647 6480464 andrographolide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31706003 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [Diethylnitrosamine affects the phosphorylation of SMAD3 protein] CTD PMID:19418558 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:735647 6480464 [pyrazolanthrone co-treated with 6 more ... CTD PMID:31447676 antirheumatic drug decreases expression ISO RGD:1343311 6480464 Antirheumatic Agents results in decreased expression of SMAD3 mRNA CTD PMID:24449571 aripiprazole multiple interactions ISO RGD:1343311 6480464 [Aripiprazole co-treated with Ozone] results in increased expression of SMAD3 mRNA CTD PMID:31476115 arsane multiple interactions EXP 6480464 Grape Seed Extract inhibits the reaction [Arsenic results in increased expression of SMAD3 protein modified form] CTD PMID:24348802 arsane increases expression EXP 6480464 Arsenic results in increased expression of SMAD3 protein modified form CTD PMID:24348802 arsenic atom multiple interactions EXP 6480464 Grape Seed Extract inhibits the reaction [Arsenic results in increased expression of SMAD3 protein modified form] CTD PMID:24348802 arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of SMAD3 protein modified form CTD PMID:24348802 arsenite(3-) multiple interactions ISO RGD:735647 6480464 arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein] more ... CTD PMID:25145660 , PMID:26354774 arsenous acid decreases expression ISO RGD:1343311 6480464 Arsenic Trioxide results in decreased expression of SMAD3 mRNA, Arsenic Trioxide results in decreased expression of SMAD3 protein CTD PMID:25196641 , PMID:25304214 arsenous acid increases expression ISO RGD:1343311 6480464 Arsenic Trioxide results in increased expression of SMAD3 mRNA CTD PMID:29633893 arsenous acid decreases response to substance ISO RGD:1343311 6480464 SMAD3 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 arsenous acid multiple interactions ISO RGD:1343311 6480464 [Arsenic Trioxide results in increased expression of MIR491 mRNA] which results in decreased expression of SMAD3 mRNA more ... CTD PMID:21649584 more ... asbestos multiple interactions ISO RGD:1343311 6480464 [Asbestos more ... CTD PMID:25358858 azoxystrobin decreases expression ISO RGD:1343311 6480464 azoxystrobin results in decreased expression of SMAD3 mRNA CTD PMID:33512557 benazepril affects expression EXP 6480464 benazepril affects the expression of SMAD3 mRNA, benazepril affects the expression of SMAD3 protein CTD PMID:16635409 benazepril multiple interactions EXP 6480464 [benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein more ... CTD PMID:16635409 , PMID:19487956 benzene increases expression ISO RGD:1343311 6480464 Benzene results in increased expression of SMAD3 mRNA CTD PMID:19162166 benzo[a]pyrene increases expression ISO RGD:735647 6480464 Benzo(a)pyrene results in increased expression of SMAD3 mRNA CTD PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:1343311 6480464 Benzo(a)pyrene affects the methylation of SMAD3 promoter CTD PMID:27901495 , PMID:30157460 benzo[a]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:18711122 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1343311 6480464 7 more ... CTD PMID:19150397 , PMID:20018196 benzo[b]fluoranthene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SMAD3 mRNA CTD PMID:18711122 benzo[e]pyrene increases methylation ISO RGD:1343311 6480464 benzo(e)pyrene results in increased methylation of SMAD3 intron CTD PMID:30157460 benzophenone decreases phosphorylation ISO RGD:1343311 6480464 benzophenone results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 benzophenone multiple interactions ISO RGD:1343311 6480464 fulvestrant inhibits the reaction [benzophenone results in decreased phosphorylation of SMAD3 protein] CTD PMID:24308608 betulin multiple interactions EXP 6480464 betulin inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 bis(2-chloroethyl) sulfide decreases expression ISO RGD:735647 6480464 Mustard Gas results in decreased expression of SMAD3 mRNA CTD PMID:15674843 bisphenol A decreases phosphorylation ISO RGD:1343311 6480464 bisphenol A results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 , PMID:26407941 bisphenol A decreases expression ISO RGD:1343311 6480464 bisphenol A analog results in decreased expression of SMAD3 mRNA CTD PMID:32387340 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SMAD3 mRNA CTD PMID:30816183 , PMID:34097993 bisphenol A increases methylation ISO RGD:1343311 6480464 bisphenol A results in increased methylation of SMAD3 promoter CTD PMID:27271280 bisphenol A affects methylation ISO RGD:735647 6480464 bisphenol A affects the methylation of SMAD3 promoter CTD PMID:27334623 bisphenol A multiple interactions ISO RGD:1343311 6480464 [bisphenol A co-treated with Fulvestrant] affects the methylation of SMAD3 gene more ... CTD PMID:24308608 more ... bleomycin A2 multiple interactions ISO RGD:735647 6480464 2-((dimethylamino)methyl)-9-hydroxythieno(2 more ... CTD PMID:27704718 more ... bleomycin A2 increases expression EXP 6480464 Bleomycin results in increased expression of SMAD3 mRNA CTD PMID:26093215 bleomycin A2 multiple interactions EXP 6480464 Phytochemicals inhibits the reaction [Bleomycin results in increased expression of SMAD3 mRNA] CTD PMID:26093215 bleomycin A2 increases phosphorylation ISO RGD:735647 6480464 Bleomycin results in increased phosphorylation of SMAD3 protein CTD PMID:27704718 more ... butan-1-ol multiple interactions ISO RGD:1343311 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SMAD3 mRNA CTD PMID:29432896 butanal decreases expression ISO RGD:1343311 6480464 butyraldehyde results in decreased expression of SMAD3 mRNA CTD PMID:26079696 cadmium atom decreases expression ISO RGD:1343311 6480464 Cadmium results in decreased expression of SMAD3 mRNA CTD PMID:33559965 cadmium atom multiple interactions ISO RGD:1343311 6480464 [Acetylcysteine co-treated with Cadmium] results in decreased expression of SMAD3 mRNA more ... CTD PMID:29408318 more ... cadmium dichloride multiple interactions ISO RGD:1343311 6480464 [Acetylcysteine co-treated with Cadmium Chloride co-treated with sodium arsenite] results in decreased expression of SMAD3 mRNA more ... CTD PMID:29408318 more ... caffeine decreases expression EXP 6480464 Caffeine results in decreased expression of SMAD3 mRNA CTD PMID:32663519 caffeine multiple interactions ISO RGD:735647 6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 candesartan multiple interactions EXP 6480464 [benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein CTD PMID:19487956 Candesartan cilexetil multiple interactions EXP 6480464 candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD3 protein modified form] CTD PMID:27889505 cantharidin multiple interactions ISO RGD:1343311 6480464 Cantharidin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 carbamazepine affects expression ISO RGD:1343311 6480464 Carbamazepine affects the expression of SMAD3 mRNA CTD PMID:25979313 carbofuran increases expression EXP 6480464 Carbofuran results in increased expression of SMAD3 mRNA CTD PMID:28982980 carbofuran multiple interactions EXP 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD3 protein] CTD PMID:28982980 carbofuran increases phosphorylation EXP 6480464 Carbofuran results in increased phosphorylation of SMAD3 protein CTD PMID:28982980 casticin increases expression ISO RGD:1343311 6480464 casticin results in increased expression of SMAD3 mRNA CTD PMID:27862857 celastrol multiple interactions ISO RGD:1343311 6480464 celastrol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:29789558 CGP 52608 multiple interactions ISO RGD:1343311 6480464 CGP 52608 promotes the reaction [RORA protein binds to SMAD3 gene] CTD PMID:28238834 CGS-21680 multiple interactions EXP 6480464 8-(4-methoxyphenyl)-4-oxo-4 more ... CTD PMID:22063920 chlorpyrifos increases phosphorylation ISO RGD:1343311 6480464 Chlorpyrifos results in increased phosphorylation of SMAD3 protein CTD PMID:32156659 cholesterol multiple interactions ISO RGD:735647 6480464 [Cholesterol co-treated with 1, 2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of SMAD3 mRNA CTD PMID:22129739 choline multiple interactions ISO RGD:735647 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene more ... CTD PMID:20938992 , PMID:22915297 chromium(6+) decreases expression ISO RGD:1343311 6480464 chromium hexavalent ion results in decreased expression of SMAD3 mRNA CTD PMID:30690063 chrysin multiple interactions ISO RGD:735647 6480464 chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:26297989 cisplatin decreases expression ISO RGD:735647 6480464 Cisplatin results in decreased expression of SMAD3 protein CTD PMID:23628706 cisplatin increases expression ISO RGD:1343311 6480464 Cisplatin results in increased expression of SMAD3 mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:1343311 6480464 Cisplatin results in decreased expression of SMAD3 mRNA CTD PMID:19561079 cisplatin multiple interactions ISO RGD:1343311 6480464 [Cisplatin co-treated with Paclitaxel] results in decreased expression of SMAD3 mRNA CTD PMID:20705681 cocaine multiple interactions EXP 6480464 Cocaine deficiency promotes the reaction [SMARCA4 protein binds to SMAD3 protein] CTD PMID:27422367 coenzyme Q10 multiple interactions EXP 6480464 coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] CTD PMID:27174133 copper atom multiple interactions ISO RGD:1343311 6480464 [Chelating Agents binds to Copper] which results in increased expression of SMAD3 mRNA, [Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA CTD PMID:24690739 , PMID:30911355 copper(0) multiple interactions ISO RGD:1343311 6480464 [Chelating Agents binds to Copper] which results in increased expression of SMAD3 mRNA, [Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA CTD PMID:24690739 , PMID:30911355 copper(II) sulfate increases expression ISO RGD:1343311 6480464 Copper Sulfate results in increased expression of SMAD3 mRNA CTD PMID:19549813 copper(II) sulfate increases phosphorylation ISO RGD:735647 6480464 Copper Sulfate results in increased phosphorylation of SMAD3 protein CTD PMID:33744278 corosolic acid multiple interactions ISO RGD:735647 6480464 corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of SMAD3 gene] CTD PMID:32135139 corticosterone decreases expression EXP 6480464 Corticosterone results in decreased expression of SMAD3 mRNA CTD PMID:29660438 , PMID:32663519 coumestrol decreases expression ISO RGD:1343311 6480464 Coumestrol results in decreased expression of SMAD3 mRNA CTD PMID:19167446 coumestrol multiple interactions ISO RGD:1343311 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD3 mRNA CTD PMID:19167446 crocidolite asbestos decreases expression ISO RGD:735647 6480464 Asbestos, Crocidolite results in decreased expression of SMAD3 mRNA CTD PMID:29279043 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter], Curcumin inhibits the reaction [AGT protein results in increased phosphorylation of SMAD3 protein] CTD PMID:16959952 , PMID:26648693 cyclosporin A increases expression ISO RGD:1343311 6480464 Cyclosporine results in increased expression of SMAD3 mRNA CTD PMID:25562108 cyclosporin A increases methylation ISO RGD:1343311 6480464 Cyclosporine results in increased methylation of SMAD3 promoter CTD PMID:27989131 cytochalasin D affects localization ISO RGD:1343311 6480464 Cytochalasin D affects the localization of SMAD3 protein CTD PMID:25756282 D-glucose multiple interactions ISO RGD:1343311 6480464 4-(4-((5-(4 more ... CTD PMID:17597607 , PMID:26045780 D-glucose increases phosphorylation ISO RGD:1343311 6480464 Glucose results in increased phosphorylation of SMAD3 protein CTD PMID:26045780 deguelin decreases phosphorylation ISO RGD:1343311 6480464 deguelin results in decreased phosphorylation of SMAD3 protein CTD PMID:22986522 dexamethasone affects expression ISO RGD:735647 6480464 Dexamethasone affects the expression of SMAD3 mRNA CTD PMID:21277400 dexamethasone decreases expression ISO RGD:735647 6480464 Dexamethasone results in decreased expression of SMAD3 mRNA CTD PMID:29329878 diarsenic trioxide multiple interactions ISO RGD:1343311 6480464 [Arsenic Trioxide results in increased expression of MIR491 mRNA] which results in decreased expression of SMAD3 mRNA more ... CTD PMID:21649584 more ... diarsenic trioxide decreases response to substance ISO RGD:1343311 6480464 SMAD3 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 diarsenic trioxide increases expression ISO RGD:1343311 6480464 Arsenic Trioxide results in increased expression of SMAD3 mRNA CTD PMID:29633893 diarsenic trioxide decreases expression ISO RGD:1343311 6480464 Arsenic Trioxide results in decreased expression of SMAD3 mRNA, Arsenic Trioxide results in decreased expression of SMAD3 protein CTD PMID:25196641 , PMID:25304214 dibenz[a,h]anthracene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:18711122 dibenzo[a,l]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with dibenzo(a, l)pyrene] affects the expression of SMAD3 mRNA CTD PMID:18711122 dibutyl phthalate increases expression ISO RGD:735647 6480464 Dibutyl Phthalate results in increased expression of SMAD3 mRNA CTD PMID:21266533 diminazene diaceturate decreases phosphorylation ISO RGD:1343311 6480464 diminazene aceturate results in decreased phosphorylation of SMAD3 protein CTD PMID:29977014 dioxygen increases expression ISO RGD:735647 6480464 Oxygen deficiency results in increased expression of SMAD3 mRNA CTD PMID:24205000 dioxygen multiple interactions ISO RGD:1343311 6480464 Oxygen affects the reaction [AHR protein results in decreased expression of SMAD3 mRNA] CTD PMID:27103661 disodium selenite increases expression ISO RGD:1343311 6480464 Sodium Selenite results in increased expression of SMAD3 mRNA CTD PMID:18175754 disodium selenite multiple interactions ISO RGD:735647 6480464 [Folic Acid co-treated with INS protein co-treated with TF protein co-treated with Sodium Selenite] results in increased expression of SMAD3 mRNA CTD PMID:32324263 disulfiram multiple interactions ISO RGD:1343311 6480464 [Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA CTD PMID:24690739 doxorubicin multiple interactions ISO RGD:1343311 6480464 Doxorubicin inhibits the reaction [TGFB1 protein results in increased localization of SMAD3 protein] CTD PMID:18606404 doxorubicin multiple interactions ISO RGD:735647 6480464 Niclosamide inhibits the reaction [Doxorubicin results in increased phosphorylation of SMAD3 protein] CTD PMID:28318631 doxorubicin increases phosphorylation ISO RGD:735647 6480464 Doxorubicin results in increased phosphorylation of SMAD3 protein CTD PMID:28318631 doxorubicin decreases expression ISO RGD:1343311 6480464 Doxorubicin results in decreased expression of SMAD3 mRNA, Doxorubicin results in decreased expression of SMAD3 protein CTD PMID:18606404 , PMID:29803840 ebselen multiple interactions ISO RGD:1343311 6480464 ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21131394 Enterolactone decreases expression ISO RGD:1343311 6480464 2, 3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of SMAD3 mRNA CTD PMID:19167446 Enterolactone multiple interactions ISO RGD:1343311 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD3 mRNA CTD PMID:19167446 ethanol multiple interactions EXP 6480464 8-(4-methoxyphenyl)-4-oxo-4 more ... CTD PMID:21172400 more ... ethanol affects splicing ISO RGD:735647 6480464 Ethanol affects the splicing of SMAD3 mRNA CTD PMID:30319688 ethanol increases expression ISO RGD:1343311 6480464 Ethanol results in increased expression of SMAD3 mRNA CTD PMID:23378141 ethanol increases expression EXP 6480464 Ethanol results in increased expression of SMAD3 protein CTD PMID:23274713 ethanol increases phosphorylation EXP 6480464 Ethanol results in increased phosphorylation of SMAD3 protein CTD PMID:21172400 , PMID:22063920 ethyl methanesulfonate increases expression ISO RGD:1343311 6480464 Ethyl Methanesulfonate results in increased expression of SMAD3 mRNA CTD PMID:23649840 fenofibrate multiple interactions ISO RGD:1343311 6480464 Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]] CTD PMID:19593819 fenthion decreases expression ISO RGD:735647 6480464 Fenthion results in decreased expression of SMAD3 mRNA CTD PMID:34813904 ferulic acid multiple interactions EXP 6480464 ferulic acid inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein] CTD PMID:32278740 fipronil decreases expression EXP 6480464 fipronil results in decreased expression of SMAD3 mRNA CTD PMID:23962444 fluoranthene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of SMAD3 mRNA CTD PMID:18711122 fluoranthene multiple interactions ISO RGD:735647 6480464 [1-methylanthracene co-treated with fluoranthene] results in increased expression of SMAD3 mRNA CTD PMID:28329830 folic acid multiple interactions ISO RGD:735647 6480464 6 more ... CTD PMID:20938992 more ... folic acid multiple interactions ISO RGD:1343311 6480464 Folic Acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:29380373 folic acid increases phosphorylation ISO RGD:735647 6480464 Folic Acid results in increased phosphorylation of SMAD3 protein CTD PMID:31447676 formaldehyde increases expression ISO RGD:1343311 6480464 Formaldehyde results in increased expression of SMAD3 mRNA CTD PMID:23649840 fulvestrant multiple interactions ISO RGD:1343311 6480464 [bisphenol A co-treated with Fulvestrant] affects the methylation of SMAD3 gene more ... CTD PMID:24308608 more ... fulvestrant increases methylation ISO RGD:1343311 6480464 Fulvestrant results in increased methylation of SMAD3 gene CTD PMID:31601247 galangin multiple interactions ISO RGD:1343311 6480464 LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD3 protein] CTD PMID:25268046 galangin increases phosphorylation ISO RGD:1343311 6480464 galangin results in increased phosphorylation of SMAD3 protein CTD PMID:25268046 galangin increases expression ISO RGD:1343311 6480464 galangin results in increased expression of SMAD3 mRNA CTD PMID:25268046 gallic acid multiple interactions EXP 6480464 Gallic Acid inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein] CTD PMID:32278740 Ganoderic acid A multiple interactions ISO RGD:735647 6480464 ganoderic acid A inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of SMAD3 protein] CTD PMID:34029542 genistein multiple interactions EXP 6480464 Genistein inhibits the reaction [Ethanol results in increased expression of SMAD3 protein], Genistein inhibits the reaction [Galactosamine results in increased phosphorylation of SMAD3 protein] CTD PMID:23274713 , PMID:27876602 genistein multiple interactions ISO RGD:1343311 6480464 Genistein inhibits the reaction [bisphenol A results in decreased phosphorylation of SMAD3 protein] more ... CTD PMID:26407941 genistein affects response to substance ISO RGD:1343311 6480464 SMAD3 protein affects the susceptibility to Genistein CTD PMID:22228119 genistein decreases expression ISO RGD:1343311 6480464 Genistein results in decreased expression of SMAD3 mRNA, Genistein results in decreased expression of SMAD3 protein CTD PMID:22228119 geraniol decreases expression ISO RGD:1343311 6480464 geraniol results in decreased expression of SMAD3 mRNA CTD PMID:27683099 glucose multiple interactions ISO RGD:1343311 6480464 4-(4-((5-(4 more ... CTD PMID:17597607 , PMID:26045780 glucose increases phosphorylation ISO RGD:1343311 6480464 Glucose results in increased phosphorylation of SMAD3 protein CTD PMID:26045780 glyphosate decreases expression ISO RGD:1343311 6480464 glyphosate results in decreased expression of SMAD3 mRNA CTD PMID:31295307 heptachlor increases expression ISO RGD:1343311 6480464 Heptachlor results in increased expression of SMAD3 mRNA, Heptachlor results in increased expression of SMAD3 protein modified form CTD PMID:30719927 hexachlorobenzene increases phosphorylation ISO RGD:735647 6480464 Hexachlorobenzene results in increased phosphorylation of SMAD3 protein CTD PMID:28923513 hexachlorobenzene multiple interactions ISO RGD:1343311 6480464 AG 1879 inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:27519288 Honokiol multiple interactions ISO RGD:1343311 6480464 honokiol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:32032644 Honokiol multiple interactions EXP 6480464 honokiol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21265825 Honokiol multiple interactions ISO RGD:735647 6480464 honokiol inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] CTD PMID:32032644 hyaluronic acid multiple interactions ISO RGD:1343311 6480464 [4-(5-benzo(1 more ... CTD PMID:21520325 hydrogen peroxide increases secretion ISO RGD:735647 6480464 Hydrogen Peroxide results in increased secretion of SMAD3 mRNA CTD PMID:21179422 hydrogen peroxide increases phosphorylation ISO RGD:1343311 6480464 Hydrogen Peroxide results in increased phosphorylation of SMAD3 protein CTD PMID:15147944 , PMID:24762191 hydrogen peroxide multiple interactions ISO RGD:1343311 6480464 Arsenic Trioxide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:24762191 irbesartan multiple interactions EXP 6480464 [benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA, [benazepril co-treated with irbesartan] affects the expression of SMAD3 protein CTD PMID:16635409 irbesartan affects expression EXP 6480464 irbesartan affects the expression of SMAD3 mRNA, irbesartan affects the expression of SMAD3 protein CTD PMID:16635409 irinotecan decreases expression ISO RGD:1343311 6480464 Irinotecan analog results in decreased expression of SMAD3 mRNA CTD PMID:18927307 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of SMAD3 mRNA CTD PMID:35014750 isorhamnetin multiple interactions ISO RGD:1343311 6480464 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein], NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] CTD PMID:27151496 L-methionine multiple interactions ISO RGD:735647 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene more ... CTD PMID:20938992 , PMID:22915297 lead diacetate increases methylation EXP 6480464 lead acetate results in increased methylation of SMAD3 gene CTD PMID:29571894 leptomycin B multiple interactions ISO RGD:735647 6480464 leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]] more ... CTD PMID:26354774 linoleic acid decreases abundance ISO RGD:735647 6480464 SMAD3 protein results in decreased abundance of Linoleic Acid CTD PMID:23034213 lipoic acid multiple interactions ISO RGD:735647 6480464 Thioctic Acid inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] CTD PMID:35187969 lipopolysaccharide multiple interactions ISO RGD:735647 6480464 [Lipopolysaccharides results in increased phosphorylation of SMAD3 protein] promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]] more ... CTD PMID:21295571 lipopolysaccharide increases response to substance ISO RGD:735647 6480464 SMAD3 protein results in increased susceptibility to Lipopolysaccharides CTD PMID:21131441 lipopolysaccharide increases phosphorylation ISO RGD:735647 6480464 Lipopolysaccharides results in increased phosphorylation of SMAD3 protein CTD PMID:21295571 lithocholic acid multiple interactions ISO RGD:735647 6480464 SMAD3 protein promotes the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA] more ... CTD PMID:23034213 lithocholic acid increases response to substance ISO RGD:735647 6480464 SMAD3 protein results in increased susceptibility to Lithocholic Acid CTD PMID:23034213 LY-2157299 multiple interactions EXP 6480464 LY-2157299 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:35122773 LY-2157299 multiple interactions ISO RGD:1343311 6480464 LY-2157299 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:35122773 lycopene increases expression ISO RGD:1343311 6480464 lycopene results in increased expression of SMAD3 mRNA CTD PMID:16886892 melphalan decreases expression ISO RGD:1343311 6480464 Melphalan results in decreased expression of SMAD3 mRNA CTD PMID:22363485 menadione affects expression ISO RGD:1343311 6480464 Vitamin K 3 affects the expression of SMAD3 mRNA CTD PMID:20044591 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of SMAD3 mRNA CTD PMID:19564919 methamphetamine multiple interactions EXP 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of SMAD3 mRNA CTD PMID:19564919 methapyrilene increases methylation ISO RGD:1343311 6480464 Methapyrilene results in increased methylation of SMAD3 intron CTD PMID:30157460 Methylazoxymethanol acetate increases expression EXP 6480464 Methylazoxymethanol Acetate results in increased expression of SMAD3 mRNA CTD PMID:28349193 methylmercury chloride increases expression ISO RGD:735647 6480464 methylmercuric chloride results in increased expression of SMAD3 mRNA CTD PMID:20061341 methylmercury chloride decreases expression ISO RGD:1343311 6480464 methylmercuric chloride results in decreased expression of SMAD3 mRNA CTD PMID:28001369 methylparaben decreases expression ISO RGD:1343311 6480464 methylparaben results in decreased expression of SMAD3 mRNA CTD PMID:31745603 mirtazapine multiple interactions ISO RGD:735647 6480464 mirtazapine inhibits the reaction [Thioacetamide results in increased expression of SMAD3 protein modified form] CTD PMID:28623179 Muraglitazar decreases expression EXP 6480464 muraglitazar results in decreased expression of SMAD3 mRNA CTD PMID:21515302 N-acetyl-L-cysteine multiple interactions ISO RGD:1343311 6480464 [Acetylcysteine co-treated with Cadmium Chloride co-treated with sodium arsenite] results in decreased expression of SMAD3 mRNA more ... CTD PMID:21131394 more ... N-acetyl-L-cysteine decreases phosphorylation ISO RGD:1343311 6480464 Acetylcysteine results in decreased phosphorylation of SMAD3 protein CTD PMID:34687772 N-nitrosodiethylamine multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein more ... CTD PMID:15368444 , PMID:19418558 N-nitrosodiethylamine multiple interactions ISO RGD:735647 6480464 salvianolic acid B affects the reaction [Diethylnitrosamine results in decreased expression of SMAD3 protein modified form] more ... CTD PMID:33290806 N-nitrosodiethylamine decreases expression ISO RGD:735647 6480464 Diethylnitrosamine results in decreased expression of SMAD3 protein modified form CTD PMID:33290806 N-nitrosodiethylamine increases phosphorylation ISO RGD:735647 6480464 Diethylnitrosamine results in increased phosphorylation of SMAD3 protein CTD PMID:33290806 N-nitrosodiethylamine affects phosphorylation EXP 6480464 Diethylnitrosamine affects the phosphorylation of SMAD3 protein CTD PMID:19418558 naringin multiple interactions EXP 6480464 naringin inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] CTD PMID:27174133 niclosamide multiple interactions EXP 6480464 Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:28318631 niclosamide multiple interactions ISO RGD:735647 6480464 Niclosamide inhibits the reaction [Doxorubicin results in increased phosphorylation of SMAD3 protein] CTD PMID:28318631 niclosamide multiple interactions ISO RGD:1343311 6480464 HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] more ... CTD PMID:28318631 nicotine multiple interactions ISO RGD:735647 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 nicotine multiple interactions EXP 6480464 Nicotine results in increased expression of and results in increased phosphorylation of SMAD3 protein CTD PMID:22691361 nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of SMAD3 mRNA CTD PMID:29660438 nitric oxide multiple interactions EXP 6480464 [SMAD4 protein co-treated with SMAD3 protein] affects the susceptibility to Nitric Oxide, Nitric Oxide results in increased activity of [SMAD4 protein binds to SMAD3 protein] CTD PMID:15949472 nitrofen decreases expression ISO RGD:735647 6480464 nitrofen results in decreased expression of SMAD3 mRNA CTD PMID:12149686 Nonylphenol decreases phosphorylation ISO RGD:1343311 6480464 nonylphenol results in decreased phosphorylation of SMAD3 protein CTD PMID:26407941 Nonylphenol multiple interactions ISO RGD:1343311 6480464 fulvestrant inhibits the reaction [nonylphenol results in decreased phosphorylation of SMAD3 protein], Genistein inhibits the reaction [nonylphenol results in decreased phosphorylation of SMAD3 protein] CTD PMID:26407941 ochratoxin A multiple interactions ISO RGD:1343311 6480464 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide inhibits the reaction [ochratoxin A results in increased expression of SMAD3 mRNA] CTD PMID:32617660 ochratoxin A increases expression ISO RGD:735647 6480464 ochratoxin A results in increased expression of SMAD3 mRNA CTD PMID:32617660 ochratoxin A increases expression ISO RGD:1343311 6480464 ochratoxin A results in increased expression of SMAD3 mRNA CTD PMID:32617660 oridonin multiple interactions ISO RGD:1343311 6480464 oridonin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:30243739 osthole multiple interactions ISO RGD:1343311 6480464 [platycodin D co-treated with osthol] inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:23603464 ozone multiple interactions ISO RGD:1343311 6480464 [Aripiprazole co-treated with Ozone] results in increased expression of SMAD3 mRNA CTD PMID:31476115 ozone increases expression ISO RGD:1343311 6480464 Ozone results in increased expression of SMAD3 mRNA CTD PMID:31476115 paclitaxel multiple interactions ISO RGD:1343311 6480464 [Cisplatin co-treated with Paclitaxel] results in decreased expression of SMAD3 mRNA CTD PMID:20705681 paracetamol increases expression ISO RGD:735647 6480464 Acetaminophen results in increased expression of SMAD3 mRNA CTD PMID:11752693 paracetamol multiple interactions ISO RGD:735647 6480464 4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide inhibits the reaction [Acetaminophen results in increased phosphorylation of SMAD3 protein] CTD PMID:31132129 paracetamol increases phosphorylation ISO RGD:735647 6480464 Acetaminophen results in increased phosphorylation of SMAD3 protein CTD PMID:31132129 paracetamol increases expression ISO RGD:1343311 6480464 Acetaminophen results in increased expression of SMAD3 mRNA CTD PMID:22230336 paracetamol decreases expression ISO RGD:1343311 6480464 Acetaminophen results in decreased expression of SMAD3 mRNA CTD PMID:21420995 paracetamol affects expression ISO RGD:735647 6480464 Acetaminophen affects the expression of SMAD3 mRNA CTD PMID:17562736 paraquat increases response to substance ISO RGD:735647 6480464 SMAD3 protein results in increased susceptibility to Paraquat CTD PMID:22581813 paraquat increases phosphorylation ISO RGD:735647 6480464 Paraquat results in increased phosphorylation of SMAD3 protein CTD PMID:32462952 paraquat increases expression ISO RGD:735647 6480464 Paraquat results in increased expression of SMAD3 mRNA CTD PMID:32462952 paraquat multiple interactions ISO RGD:735647 6480464 Xuebijing inhibits the reaction [Paraquat results in increased expression of SMAD3 mRNA], Xuebijing inhibits the reaction [Paraquat results in increased phosphorylation of SMAD3 protein] CTD PMID:32462952 paraquat increases expression EXP 6480464 Paraquat results in increased expression of SMAD3 mRNA CTD PMID:33000210 paraquat multiple interactions EXP 6480464 LY2109761 inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of SMAD3 protein] more ... CTD PMID:33000210 paraquat increases expression ISO RGD:1343311 6480464 Paraquat results in increased expression of SMAD3 protein modified form CTD PMID:27682480 paraquat multiple interactions ISO RGD:1343311 6480464 TGFB1 protein promotes the reaction [Paraquat results in increased expression of SMAD3 protein modified form] CTD PMID:27682480 patulin increases phosphorylation EXP 6480464 Patulin results in increased phosphorylation of SMAD3 protein CTD PMID:34896196 perfluorohexanesulfonic acid decreases expression ISO RGD:1343311 6480464 perfluorohexanesulfonic acid results in decreased expression of SMAD3 mRNA CTD PMID:25812627 perfluorononanoic acid decreases expression ISO RGD:1343311 6480464 perfluoro-n-nonanoic acid results in decreased expression of SMAD3 mRNA CTD PMID:25812627 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:1343311 6480464 perfluorooctane sulfonic acid results in decreased expression of SMAD3 mRNA CTD PMID:25812627 perfluorooctanoic acid decreases expression ISO RGD:1343311 6480464 perfluorooctanoic acid results in decreased expression of SMAD3 mRNA CTD PMID:25812627 perindopril multiple interactions EXP 6480464 Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] CTD PMID:16872305 perindopril decreases expression EXP 6480464 Perindopril results in decreased expression of SMAD3 protein CTD PMID:15619341 phenylarsine oxide multiple interactions ISO RGD:1343311 6480464 oxophenylarsine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 phenylmercury acetate multiple interactions ISO RGD:1343311 6480464 Phenylmercuric Acetate inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 phloroglucinol multiple interactions ISO RGD:1343311 6480464 Phloroglucinol analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:26054450 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:735647 6480464 corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased methylation of SMAD3 gene] CTD PMID:32135139 phorbol 13-acetate 12-myristate increases methylation ISO RGD:735647 6480464 Tetradecanoylphorbol Acetate results in increased methylation of SMAD3 gene CTD PMID:32135139 picoxystrobin decreases expression ISO RGD:1343311 6480464 picoxystrobin results in decreased expression of SMAD3 mRNA CTD PMID:33512557 picrotoxin increases expression EXP 6480464 Picrotoxin results in increased expression of SMAD3 mRNA CTD PMID:15170462 pirinixic acid decreases expression ISO RGD:735647 6480464 pirinixic acid results in decreased expression of SMAD3 mRNA CTD PMID:20813756 platycodin D multiple interactions ISO RGD:1343311 6480464 [platycodin D co-treated with osthol] inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:23603464 potassium chromate multiple interactions ISO RGD:1343311 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD3 mRNA CTD PMID:22079256 potassium chromate decreases expression ISO RGD:1343311 6480464 potassium chromate(VI) results in decreased expression of SMAD3 mRNA CTD PMID:22079256 , PMID:22714537 progesterone multiple interactions ISO RGD:1343311 6480464 [4-(5-benzo(1 more ... CTD PMID:20660070 , PMID:21520325 progesterone decreases expression ISO RGD:1343311 6480464 Progesterone results in decreased expression of SMAD3 mRNA CTD PMID:20864642 quercetin multiple interactions ISO RGD:1343311 6480464 Quercetin inhibits the reaction [SMAD2 protein modified form binds to SMAD3 protein modified form binds to SMAD4 protein], SHH protein inhibits the reaction [Quercetin results in decreased phosphorylation of SMAD3 protein] CTD PMID:15580028 , PMID:33070227 quercetin multiple interactions ISO RGD:735647 6480464 Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SMAD3 mRNA], Quercetin promotes the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21216973 , PMID:22915297 quercetin decreases phosphorylation ISO RGD:1343311 6480464 Quercetin results in decreased phosphorylation of SMAD3 protein CTD PMID:33070227 quercetin decreases expression ISO RGD:1343311 6480464 Quercetin results in decreased expression of SMAD3 protein, Quercetin results in decreased expression of SMAD3 protein modified form CTD PMID:15580028 quercitrin increases expression ISO RGD:1343311 6480464 quercitrin results in increased expression of SMAD3 mRNA CTD PMID:25193878 rac-lactic acid increases expression ISO RGD:1343311 6480464 Lactic Acid results in increased expression of SMAD3 mRNA CTD PMID:30851411 reactive oxygen species affects expression ISO RGD:1343311 6480464 Reactive Oxygen Species affects the expression of SMAD3 mRNA CTD PMID:25800948 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD3 protein] CTD PMID:21300041 resveratrol multiple interactions ISO RGD:1343311 6480464 resveratrol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:27345520 resveratrol multiple interactions ISO RGD:735647 6480464 resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of SMAD3 protein] CTD PMID:25234611 resveratrol decreases expression ISO RGD:1343311 6480464 resveratrol results in decreased expression of SMAD3 mRNA, resveratrol results in decreased expression of SMAD3 protein CTD PMID:18089832 , PMID:25721869 resveratrol decreases acetylation EXP 6480464 resveratrol results in decreased acetylation of SMAD3 protein CTD PMID:20651248 resveratrol decreases acetylation ISO RGD:735647 6480464 resveratrol results in decreased acetylation of SMAD3 protein CTD PMID:20651248 resveratrol decreases phosphorylation ISO RGD:735647 6480464 resveratrol results in decreased phosphorylation of SMAD3 protein CTD PMID:21679764 rotenone decreases expression ISO RGD:1343311 6480464 Rotenone results in decreased expression of SMAD3 mRNA CTD PMID:33512557 S-(1,2-dichlorovinyl)-L-cysteine decreases expression ISO RGD:1343311 6480464 S-(1, 2-dichlorovinyl)cysteine results in decreased expression of SMAD3 mRNA CTD PMID:33725128 , PMID:35811015 salvianolic acid B multiple interactions ISO RGD:1343311 6480464 salvianolic acid B affects the reaction [TGFB1 protein affects the reaction [SMAD3 protein mutant form affects the expression of CDKN1A protein]] CTD PMID:33290806 salvianolic acid B multiple interactions ISO RGD:735647 6480464 salvianolic acid B affects the reaction [Diethylnitrosamine results in decreased expression of SMAD3 protein modified form] more ... CTD PMID:33290806 salvianolic acid B affects response to substance ISO RGD:735647 6480464 SMAD3 protein modified form affects the susceptibility to salvianolic acid B CTD PMID:33290806 SB 203580 multiple interactions ISO RGD:1343311 6480464 SB 203580 inhibits the reaction [TGFB2 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:18253093 SB 431542 decreases phosphorylation EXP 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased phosphorylation of SMAD3 protein CTD PMID:28982980 SB 431542 multiple interactions ISO RGD:735647 6480464 4-(5-benzo(1 more ... CTD PMID:21586554 , PMID:29127033 SB 431542 multiple interactions ISO RGD:1343311 6480464 4-(5-benzo(1 more ... CTD PMID:21520325 , PMID:28871336 SB 431542 decreases phosphorylation ISO RGD:735647 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased phosphorylation of SMAD3 protein CTD PMID:29127033 SB 431542 multiple interactions EXP 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD3 protein] CTD PMID:28982980 SCH 23390 increases expression EXP 6480464 SCH 23390 results in increased expression of SMAD3 mRNA CTD PMID:19564919 SCH 23390 multiple interactions EXP 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of SMAD3 mRNA CTD PMID:19564919 serpentine asbestos multiple interactions ISO RGD:1343311 6480464 [Asbestos more ... CTD PMID:25358858 sevoflurane multiple interactions ISO RGD:735647 6480464 TGFB1 protein affects the reaction [sevoflurane affects the localization of SMAD3 protein] CTD PMID:18434384 sevoflurane affects response to substance ISO RGD:735647 6480464 SMAD3 protein affects the susceptibility to sevoflurane CTD PMID:18434384 silicon dioxide multiple interactions ISO RGD:1343311 6480464 NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]], tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein] CTD PMID:32097614 silicon dioxide increases phosphorylation ISO RGD:1343311 6480464 Silicon Dioxide results in increased phosphorylation of SMAD3 protein CTD PMID:32097614 silver atom increases expression ISO RGD:1343311 6480464 Silver results in increased expression of SMAD3 mRNA CTD PMID:28959546 silver(0) increases expression ISO RGD:1343311 6480464 Silver results in increased expression of SMAD3 mRNA CTD PMID:28959546 silver(1+) nitrate decreases expression ISO RGD:1343311 6480464 Silver Nitrate analog results in decreased expression of SMAD3 mRNA CTD PMID:22831968 silver(1+) nitrate increases expression ISO RGD:1343311 6480464 Silver Nitrate results in increased expression of SMAD3 mRNA CTD PMID:22831968 simvastatin increases expression ISO RGD:735647 6480464 Simvastatin results in increased expression of SMAD3 mRNA CTD PMID:18310456 simvastatin increases phosphorylation ISO RGD:735647 6480464 Simvastatin results in increased phosphorylation of SMAD3 protein CTD PMID:33034787 simvastatin multiple interactions ISO RGD:735647 6480464 FST protein inhibits the reaction [Simvastatin results in increased phosphorylation of SMAD3 protein] CTD PMID:33034787 simvastatin decreases phosphorylation EXP 6480464 Simvastatin results in decreased phosphorylation of SMAD3 protein CTD PMID:19659652 sodium arsenate increases expression ISO RGD:735647 6480464 sodium arsenate results in increased expression of SMAD3 mRNA CTD PMID:21795629 sodium arsenite multiple interactions ISO RGD:735647 6480464 IFNG protein inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:17003472 , PMID:23732083 sodium arsenite multiple interactions ISO RGD:1343311 6480464 [Acetylcysteine co-treated with Cadmium Chloride co-treated with sodium arsenite] results in decreased expression of SMAD3 mRNA CTD PMID:29408318 sodium arsenite increases phosphorylation EXP 6480464 sodium arsenite results in increased phosphorylation of SMAD3 protein CTD PMID:21605584 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of SMAD3 mRNA, sodium arsenite results in increased expression of SMAD3 protein modified form CTD PMID:27174133 more ... sodium arsenite multiple interactions EXP 6480464 candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD3 protein modified form] more ... CTD PMID:21605584 more ... sodium arsenite decreases phosphorylation ISO RGD:735647 6480464 sodium arsenite results in decreased phosphorylation of SMAD3 protein CTD PMID:23732083 sodium fluoride increases expression ISO RGD:735647 6480464 Sodium Fluoride results in increased expression of SMAD3 mRNA CTD PMID:29127033 sodium fluoride multiple interactions ISO RGD:735647 6480464 4-(5-benzo(1 more ... CTD PMID:29127033 sorafenib affects localization ISO RGD:735647 6480464 sorafenib affects the localization of SMAD3 protein CTD PMID:21360571 sorafenib multiple interactions ISO RGD:735647 6480464 sorafenib inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21360571 streptozocin multiple interactions EXP 6480464 resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD3 protein] CTD PMID:21300041 streptozocin multiple interactions ISO RGD:735647 6480464 [fatostatin co-treated with Streptozocin] results in increased phosphorylation of SMAD3 protein CTD PMID:29420703 streptozocin increases phosphorylation ISO RGD:735647 6480464 Streptozocin results in increased phosphorylation of SMAD3 protein CTD PMID:29420703 streptozocin increases phosphorylation EXP 6480464 Streptozocin results in increased phosphorylation of SMAD3 protein CTD PMID:21300041 tacrolimus hydrate multiple interactions EXP 6480464 Tacrolimus inhibits the reaction [Paraquat results in increased expression of and results in increased secretion of SMAD3 protein], Tacrolimus inhibits the reaction [Paraquat results in increased expression of SMAD3 mRNA] CTD PMID:33000210 tamoxifen multiple interactions ISO RGD:1343311 6480464 Tamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD3 protein] CTD PMID:17098229 tamoxifen multiple interactions ISO RGD:735647 6480464 [Tamoxifen co-treated with Zearalenone] results in increased expression of SMAD3 mRNA CTD PMID:30138655 tamoxifen increases phosphorylation ISO RGD:1343311 6480464 Tamoxifen results in increased phosphorylation of SMAD3 protein CTD PMID:17098229 Tanshinone I multiple interactions ISO RGD:1343311 6480464 NFE2L2 protein promotes the reaction [tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein]], tanshinone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SMAD3 protein] CTD PMID:32097614 tauro-beta-muricholic acid increases abundance ISO RGD:735647 6480464 SMAD3 protein results in increased abundance of tauromuricholic acid CTD PMID:23034213 taurochenodeoxycholic acid increases abundance ISO RGD:735647 6480464 SMAD3 protein results in increased abundance of Taurochenodeoxycholic Acid CTD PMID:23034213 taurolithocholic acid increases abundance ISO RGD:735647 6480464 SMAD3 protein results in increased abundance of Taurolithocholic Acid CTD PMID:23034213 tauroursodeoxycholic acid increases abundance ISO RGD:735647 6480464 SMAD3 protein results in increased abundance of ursodoxicoltaurine CTD PMID:23034213 temozolomide increases expression ISO RGD:1343311 6480464 Temozolomide results in increased expression of SMAD3 mRNA CTD PMID:31758290 tert-butyl hydroperoxide increases expression ISO RGD:1343311 6480464 tert-Butylhydroperoxide results in increased expression of SMAD3 mRNA CTD PMID:27509014 tert-butyl hydroperoxide increases methylation ISO RGD:1343311 6480464 tert-Butylhydroperoxide results in increased methylation of SMAD3 gene CTD PMID:27509014 Tesaglitazar decreases expression EXP 6480464 tesaglitazar results in decreased expression of SMAD3 mRNA CTD PMID:21515302 testosterone increases expression ISO RGD:735647 6480464 Testosterone results in increased expression of SMAD3 mRNA CTD PMID:22138414 tetrachloromethane increases phosphorylation EXP 6480464 Carbon Tetrachloride results in increased phosphorylation of SMAD3 protein CTD PMID:24211420 , PMID:25150141 tetrachloromethane increases phosphorylation ISO RGD:735647 6480464 Carbon Tetrachloride results in increased phosphorylation of SMAD3 protein CTD PMID:34029542 tetrachloromethane increases expression ISO RGD:735647 6480464 Carbon Tetrachloride results in increased expression of SMAD3 mRNA, Carbon Tetrachloride results in increased expression of SMAD3 protein CTD PMID:18395914 more ... tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of SMAD3 mRNA, Carbon Tetrachloride results in increased expression of SMAD3 protein CTD PMID:15818738 more ... tetrachloromethane multiple interactions EXP 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased phosphorylation of SMAD3 protein more ... CTD PMID:15818738 more ... tetrachloromethane increases activity EXP 6480464 Carbon Tetrachloride results in increased activity of SMAD3 protein CTD PMID:17009398 tetrachloromethane affects response to substance ISO RGD:735647 6480464 SMAD3 protein affects the susceptibility to Carbon Tetrachloride CTD PMID:16382155 tetrachloromethane multiple interactions ISO RGD:735647 6480464 Carbon Tetrachloride inhibits the reaction [HGF protein affects the localization of SMAD3 protein] more ... CTD PMID:18395096 more ... thioacetamide multiple interactions ISO RGD:735647 6480464 mirtazapine inhibits the reaction [Thioacetamide results in increased expression of SMAD3 protein modified form] CTD PMID:28623179 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of SMAD3 mRNA CTD PMID:34492290 thioacetamide increases phosphorylation EXP 6480464 Thioacetamide results in increased phosphorylation of SMAD3 protein CTD PMID:32278740 thioacetamide multiple interactions EXP 6480464 ferulic acid inhibits the reaction [Thioacetamide results in increased phosphorylation of SMAD3 protein] more ... CTD PMID:32278740 thioacetamide increases expression ISO RGD:735647 6480464 Thioacetamide results in increased expression of SMAD3 protein modified form CTD PMID:28623179 trichostatin A affects expression ISO RGD:1343311 6480464 trichostatin A affects the expression of SMAD3 mRNA CTD PMID:28542535 troglitazone multiple interactions ISO RGD:1343311 6480464 troglitazone inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:18253093 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of SMAD3 mRNA CTD PMID:21515302 tungsten decreases expression ISO RGD:735647 6480464 Tungsten results in decreased expression of SMAD3 mRNA CTD PMID:30912803 ursodeoxycholic acid decreases expression EXP 6480464 Ursodeoxycholic Acid results in decreased expression of SMAD3 mRNA, Ursodeoxycholic Acid results in decreased expression of SMAD3 protein CTD PMID:19493473 valproic acid increases methylation ISO RGD:1343311 6480464 Valproic Acid results in increased methylation of SMAD3 gene CTD PMID:28853863 more ... valproic acid decreases expression ISO RGD:1343311 6480464 Valproic Acid results in decreased expression of SMAD3 mRNA, Valproic Acid results in decreased expression of SMAD3 protein CTD PMID:29501571 valsartan multiple interactions EXP 6480464 Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] CTD PMID:16872305 valsartan decreases expression EXP 6480464 Valsartan results in decreased expression of SMAD3 protein CTD PMID:15619341 vitamin D multiple interactions ISO RGD:1343311 6480464 HRC protein inhibits the reaction [Vitamin D inhibits the reaction [TGFB1 protein results in increased expression of SMAD3 protein]] more ... CTD PMID:33309619 vitamin D multiple interactions ISO RGD:735647 6480464 Vitamin D inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA], Vitamin D inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] CTD PMID:33309619 vitamin E increases expression ISO RGD:1343311 6480464 Vitamin E results in increased expression of SMAD3 mRNA CTD PMID:19244175 zearalenone multiple interactions ISO RGD:735647 6480464 [Tamoxifen co-treated with Zearalenone] results in increased expression of SMAD3 mRNA CTD PMID:30138655 zearalenone increases expression ISO RGD:735647 6480464 Zearalenone results in increased expression of SMAD3 mRNA CTD PMID:30138655 zinc atom multiple interactions ISO RGD:735647 6480464 Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]] more ... CTD PMID:22228435 , PMID:26354774 zinc(0) multiple interactions ISO RGD:735647 6480464 Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]] more ... CTD PMID:22228435 , PMID:26354774 ziram multiple interactions ISO RGD:1343311 6480464 Ziram inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:31652400 zoledronic acid increases expression ISO RGD:1343311 6480464 zoledronic acid results in increased expression of SMAD3 mRNA CTD PMID:24714768 zoledronic acid increases phosphorylation ISO RGD:1343311 6480464 zoledronic acid results in increased phosphorylation of SMAD3 protein CTD PMID:28871336 zoledronic acid increases phosphorylation ISO RGD:735647 6480464 zoledronic acid results in increased phosphorylation of SMAD3 protein CTD PMID:28871336 zoledronic acid multiple interactions ISO RGD:1343311 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [zoledronic acid results in increased phosphorylation of SMAD3 protein] CTD PMID:28871336 zoledronic acid increases phosphorylation EXP 6480464 zoledronic acid results in increased phosphorylation of SMAD3 protein CTD PMID:28871336
