(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1343311 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD3 mRNA CTD PMID:22079256 (S)-nicotine multiple interactions ISO RGD:735647 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SMAD3 mRNA; more ... CTD PMID:20230807 (S)-nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of SMAD3 mRNA CTD PMID:29660438 (S)-nicotine multiple interactions EXP 6480464 Nicotine results in increased expression of and results in increased phosphorylation of SMAD3 protein CTD PMID:22691361 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression ISO RGD:735647 6480464 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO RGD:735647 6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD3 mRNA; more ... CTD PMID:20230807 1-O-oleoyl-sn-glycero-3-phosphocholine decreases abundance ISO RGD:735647 6480464 SMAD3 protein results in decreased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:23034213 17alpha-ethynylestradiol decreases expression ISO RGD:735647 6480464 Ethinyl Estradiol results in decreased expression of SMAD3 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:735647 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNA CTD PMID:17942748 17beta-estradiol decreases expression ISO RGD:1343311 6480464 Estradiol results in decreased expression of SMAD3 mRNA CTD PMID:19167446 PMID:24758408 17beta-estradiol decreases phosphorylation ISO RGD:1343311 6480464 Estradiol results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 PMID:26407941 17beta-estradiol affects expression ISO RGD:1343311 6480464 Estradiol affects the expression of SMAD3 mRNA CTD PMID:14699072 PMID:22574217 17beta-estradiol multiple interactions ISO RGD:1343311 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of SMAD3 mRNA; more ... CTD PMID:20660070 more ... 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:1343311 6480464 Dihydrotestosterone results in increased expression of SMAD3 mRNA CTD PMID:16597033 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:735647 6480464 Tetrachlorodibenzodioxin results in increased expression of SMAD3 mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:735647 6480464 Tetrachlorodibenzodioxin affects the expression of SMAD3 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:735647 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SMAD3 mRNA; more ... CTD PMID:17942748 PMID:25975270 2-acetamidofluorene multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein; more ... CTD PMID:15368444 2-amino-2-deoxy-D-galactopyranose multiple interactions EXP 6480464 Genistein inhibits the reaction [Galactosamine results in increased phosphorylation of SMAD3 protein] CTD PMID:27876602 2-amino-2-deoxy-D-galactopyranose increases phosphorylation EXP 6480464 Galactosamine results in increased phosphorylation of SMAD3 protein CTD PMID:27876602 3,4-dihydroxybenzaldehyde multiple interactions ISO RGD:1343311 6480464 protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein]; more ... CTD PMID:17597607 3,4-methylenedioxymethamphetamine increases expression ISO RGD:735647 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SMAD3 mRNA CTD PMID:20188158 4-hydroxyphenyl retinamide increases expression ISO RGD:735647 6480464 Fenretinide results in increased expression of SMAD3 mRNA CTD PMID:28973697 4-nonylphenol multiple interactions ISO RGD:1343311 6480464 fulvestrant inhibits the reaction [4-nonylphenol results in decreased phosphorylation of SMAD3 protein] CTD PMID:24308608 4-nonylphenol decreases phosphorylation ISO RGD:1343311 6480464 4-nonylphenol results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 4-vinylcyclohexene dioxide affects expression ISO RGD:735647 6480464 4-vinyl-1-cyclohexene dioxide affects the expression of SMAD3 mRNA CTD PMID:20829426 acetaldehyde multiple interactions ISO RGD:1343311 6480464 SMAD3 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] CTD PMID:16025520 acetaldehyde increases phosphorylation ISO RGD:1343311 6480464 Acetaldehyde results in increased phosphorylation of SMAD3 protein CTD PMID:16025520 aflatoxin B1 increases expression ISO RGD:1343311 6480464 Aflatoxin B1 results in increased expression of SMAD3 mRNA CTD PMID:21641981 PMID:22100608 aldehydo-D-glucose multiple interactions ISO RGD:1343311 6480464 C646 compound inhibits the reaction [Glucose results in increased phosphorylation of SMAD3 protein]; more ... CTD PMID:17597607 PMID:26045780 aldehydo-D-glucose increases phosphorylation ISO RGD:1343311 6480464 Glucose results in increased phosphorylation of SMAD3 protein CTD PMID:26045780 all-trans-retinoic acid multiple interactions ISO RGD:1343311 6480464 SMAD3 protein inhibits the reaction [Tretinoin results in decreased expression of FBN2]; more ... CTD PMID:17098229 PMID:24374174 all-trans-retinoic acid increases expression ISO RGD:1343311 6480464 Tretinoin results in increased expression of SMAD3 mRNA CTD PMID:16012519 more ... all-trans-retinoic acid decreases phosphorylation ISO RGD:1343311 6480464 Tretinoin results in decreased phosphorylation of SMAD3 protein CTD PMID:24374174 all-trans-retinoic acid decreases phosphorylation ISO RGD:735647 6480464 Tretinoin results in decreased phosphorylation of SMAD3 protein CTD PMID:16410076 all-trans-retinoic acid increases phosphorylation ISO RGD:1343311 6480464 Tretinoin results in increased phosphorylation of SMAD3 protein CTD PMID:17098229 alpha-naphthoflavone multiple interactions ISO RGD:1343311 6480464 alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein] CTD PMID:27519288 Ammothamnine multiple interactions ISO RGD:735647 6480464 oxymatrine inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:18395914 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [Diethylnitrosamine affects the phosphorylation of SMAD3 protein] CTD PMID:19418558 antirheumatic drug decreases expression ISO RGD:1343311 6480464 Antirheumatic Agents results in decreased expression of SMAD3 mRNA CTD PMID:24449571 arsane multiple interactions EXP 6480464 Grape Seed Extract inhibits the reaction [Arsenic results in increased expression of SMAD3 protein modified form] CTD PMID:24348802 arsane increases expression EXP 6480464 Arsenic results in increased expression of SMAD3 protein modified form CTD PMID:24348802 arsenic atom multiple interactions EXP 6480464 Grape Seed Extract inhibits the reaction [Arsenic results in increased expression of SMAD3 protein modified form] CTD PMID:24348802 arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of SMAD3 protein modified form CTD PMID:24348802 arsenic(3+) increases expression EXP 6480464 Arsenic results in increased expression of SMAD3 protein modified form CTD PMID:24348802 arsenic(3+) multiple interactions EXP 6480464 Grape Seed Extract inhibits the reaction [Arsenic results in increased expression of SMAD3 protein modified form] CTD PMID:24348802 arsenite(3-) multiple interactions ISO RGD:735647 6480464 arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]; more ... CTD PMID:25145660 PMID:26354774 asbestos multiple interactions ISO RGD:1343311 6480464 [Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in decreased expression of and results in increased phosphorylation of SMAD3 protein; more ... CTD PMID:25358858 benazepril affects expression EXP 6480464 benazepril affects the expression of SMAD3 mRNA; more ... CTD PMID:16635409 benazepril multiple interactions EXP 6480464 [benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein; more ... CTD PMID:16635409 PMID:19487956 benzene increases expression ISO RGD:1343311 6480464 Benzene results in increased expression of SMAD3 mRNA CTD PMID:19162166 benzo[a]pyrene increases expression ISO RGD:735647 6480464 Benzo(a)pyrene results in increased expression of SMAD3 mRNA CTD PMID:22228805 benzo[a]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SMAD3 mRNA; more ... CTD PMID:18711122 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1343311 6480464 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SMAD3 mRNA CTD PMID:19150397 PMID:20018196 benzo[b]fluoranthene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of SMAD3 mRNA CTD PMID:18711122 benzophenone decreases phosphorylation ISO RGD:1343311 6480464 benzophenone results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 benzophenone multiple interactions ISO RGD:1343311 6480464 fulvestrant inhibits the reaction [benzophenone results in decreased phosphorylation of SMAD3 protein] CTD PMID:24308608 betulin multiple interactions EXP 6480464 betulin inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 betulinic acid multiple interactions EXP 6480464 betulinic acid inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein] CTD PMID:21172400 bis(2-chloroethyl) sulfide decreases expression ISO RGD:735647 6480464 Mustard Gas results in decreased expression of SMAD3 mRNA CTD PMID:15674843 bisphenol A decreases phosphorylation ISO RGD:1343311 6480464 bisphenol A results in decreased phosphorylation of SMAD3 protein CTD PMID:24308608 PMID:26407941 bisphenol A increases methylation ISO RGD:1343311 6480464 bisphenol A results in increased methylation of SMAD3 promoter CTD PMID:27271280 bisphenol A affects methylation ISO RGD:735647 6480464 bisphenol A affects the methylation of SMAD3 promoter CTD PMID:27334623 bisphenol A multiple interactions ISO RGD:1343311 6480464 fulvestrant inhibits the reaction [bisphenol A results in decreased phosphorylation of SMAD3 protein]; more ... CTD PMID:24308608 PMID:26407941 bleomycin A2 multiple interactions ISO RGD:735647 6480464 2-((dimethylamino)methyl)-9-hydroxythieno(2,3-c)isoquinolin-5(4H)-one inhibits the reaction [Bleomycin results in increased phosphorylation of SMAD3 protein] CTD PMID:27704718 bleomycin A2 increases expression EXP 6480464 Bleomycin results in increased expression of SMAD3 mRNA CTD PMID:26093215 bleomycin A2 multiple interactions EXP 6480464 Phytochemicals inhibits the reaction [Bleomycin results in increased expression of SMAD3 mRNA] CTD PMID:26093215 bleomycin A2 increases phosphorylation ISO RGD:735647 6480464 Bleomycin results in increased phosphorylation of SMAD3 protein CTD PMID:27704718 butan-1-ol multiple interactions ISO RGD:1343311 6480464 [[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SMAD3 mRNA CTD PMID:29432896 butanal decreases expression ISO RGD:1343311 6480464 butyraldehyde results in decreased expression of SMAD3 mRNA CTD PMID:26079696 cadmium atom multiple interactions ISO RGD:1343311 6480464 [Acetylcysteine co-treated with Cadmium] results in decreased expression of SMAD3 mRNA CTD PMID:29408318 cadmium dichloride multiple interactions ISO RGD:1343311 6480464 [Acetylcysteine co-treated with Cadmium Chloride co-treated with sodium arsenite] results in decreased expression of SMAD3 mRNA CTD PMID:29408318 caffeine multiple interactions ISO RGD:735647 6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD3 mRNA; more ... CTD PMID:20230807 candesartan multiple interactions EXP 6480464 [benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein CTD PMID:19487956 Candesartan cilexetil multiple interactions EXP 6480464 candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD3 protein modified form] CTD PMID:27889505 carbamazepine affects expression ISO RGD:1343311 6480464 Carbamazepine affects the expression of SMAD3 mRNA CTD PMID:25979313 carbofuran increases expression EXP 6480464 Carbofuran results in increased expression of SMAD3 mRNA CTD PMID:28982980 carbofuran multiple interactions EXP 6480464 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD3 protein] CTD PMID:28982980 carbofuran increases phosphorylation EXP 6480464 Carbofuran results in increased phosphorylation of SMAD3 protein CTD PMID:28982980 casticin increases expression ISO RGD:1343311 6480464 casticin results in increased expression of SMAD3 mRNA CTD PMID:27862857 CGS-21680 multiple interactions EXP 6480464 8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of SMAD3 protein] CTD PMID:22063920 cholesterol multiple interactions ISO RGD:735647 6480464 [Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of SMAD3 mRNA CTD PMID:22129739 choline multiple interactions ISO RGD:735647 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene; more ... CTD PMID:20938992 PMID:22915297 chrysin multiple interactions ISO RGD:735647 6480464 chrysin inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA] CTD PMID:26297989 cisplatin decreases expression ISO RGD:735647 6480464 Cisplatin results in decreased expression of SMAD3 protein CTD PMID:23628706 cisplatin increases expression ISO RGD:1343311 6480464 Cisplatin results in increased expression of SMAD3 mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:1343311 6480464 Cisplatin results in decreased expression of SMAD3 mRNA CTD PMID:19561079 cisplatin multiple interactions ISO RGD:1343311 6480464 [Cisplatin co-treated with Paclitaxel] results in decreased expression of SMAD3 mRNA CTD PMID:20705681 cocaine multiple interactions EXP 6480464 Cocaine deficiency promotes the reaction [SMARCA4 protein binds to SMAD3 protein] CTD PMID:27422367 coenzyme Q10 multiple interactions EXP 6480464 coenzyme Q10 inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] CTD PMID:27174133 copper atom multiple interactions ISO RGD:1343311 6480464 [Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA CTD PMID:24690739 copper(0) multiple interactions ISO RGD:1343311 6480464 [Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA CTD PMID:24690739 copper(2+) multiple interactions ISO RGD:1343311 6480464 [Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA CTD PMID:24690739 copper(II) sulfate increases expression ISO RGD:1343311 6480464 Copper Sulfate results in increased expression of SMAD3 mRNA CTD PMID:19549813 corticosterone decreases expression EXP 6480464 Corticosterone results in decreased expression of SMAD3 mRNA CTD PMID:29660438 coumestrol decreases expression ISO RGD:1343311 6480464 Coumestrol results in decreased expression of SMAD3 mRNA CTD PMID:19167446 coumestrol multiple interactions ISO RGD:1343311 6480464 [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD3 mRNA CTD PMID:19167446 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [[SMAD4 protein binds to SMAD3 protein] which binds to PPARG promoter] CTD PMID:16959952 cyclosporin A increases expression ISO RGD:1343311 6480464 Cyclosporine results in increased expression of SMAD3 mRNA CTD PMID:25562108 cyclosporin A increases methylation ISO RGD:1343311 6480464 Cyclosporine results in increased methylation of SMAD3 promoter CTD PMID:27989131 cytochalasin D affects localization ISO RGD:1343311 6480464 Cytochalasin D affects the localization of SMAD3 protein CTD PMID:25756282 D-glucose multiple interactions ISO RGD:1343311 6480464 C646 compound inhibits the reaction [Glucose results in increased phosphorylation of SMAD3 protein]; more ... CTD PMID:17597607 PMID:26045780 D-glucose increases phosphorylation ISO RGD:1343311 6480464 Glucose results in increased phosphorylation of SMAD3 protein CTD PMID:26045780 Deguelin decreases phosphorylation ISO RGD:1343311 6480464 deguelin results in decreased phosphorylation of SMAD3 protein CTD PMID:22986522 dexamethasone affects expression ISO RGD:735647 6480464 Dexamethasone affects the expression of SMAD3 mRNA CTD PMID:21277400 dexamethasone decreases expression ISO RGD:735647 6480464 Dexamethasone results in decreased expression of SMAD3 mRNA CTD PMID:29329878 dibenz[a,h]anthracene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of SMAD3 mRNA CTD PMID:18711122 dibenzo[a,l]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] affects the expression of SMAD3 mRNA CTD PMID:18711122 dibutyl phthalate increases expression ISO RGD:735647 6480464 Dibutyl Phthalate results in increased expression of SMAD3 mRNA CTD PMID:21266533 dioxygen increases expression ISO RGD:735647 6480464 Oxygen deficiency results in increased expression of SMAD3 mRNA CTD PMID:24205000 dioxygen multiple interactions ISO RGD:1343311 6480464 Oxygen affects the reaction [AHR protein results in decreased expression of SMAD3 mRNA] CTD PMID:27103661 disodium selenite increases expression ISO RGD:1343311 6480464 Sodium Selenite results in increased expression of SMAD3 mRNA CTD PMID:18175754 disulfiram multiple interactions ISO RGD:1343311 6480464 [Disulfiram binds to Copper] which results in increased expression of SMAD3 mRNA CTD PMID:24690739 doxorubicin multiple interactions ISO RGD:1343311 6480464 Doxorubicin inhibits the reaction [TGFB1 protein results in increased localization of SMAD3 protein] CTD PMID:18606404 doxorubicin decreases expression ISO RGD:1343311 6480464 Doxorubicin results in decreased expression of SMAD3 mRNA; more ... CTD PMID:18606404 PMID:29803840 ebselen multiple interactions ISO RGD:1343311 6480464 ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21131394 Enterolactone decreases expression ISO RGD:1343311 6480464 2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of SMAD3 mRNA CTD PMID:19167446 Enterolactone multiple interactions ISO RGD:1343311 6480464 [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SMAD3 mRNA CTD PMID:19167446 ethanol multiple interactions EXP 6480464 8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide inhibits the reaction [Ethanol results in increased phosphorylation of SMAD3 protein]; more ... CTD PMID:21172400 more ... ethanol increases expression ISO RGD:1343311 6480464 Ethanol results in increased expression of SMAD3 mRNA CTD PMID:23378141 ethanol increases expression EXP 6480464 Ethanol results in increased expression of SMAD3 protein CTD PMID:23274713 ethanol increases phosphorylation EXP 6480464 Ethanol results in increased phosphorylation of SMAD3 protein CTD PMID:21172400 PMID:22063920 ethyl methanesulfonate increases expression ISO RGD:1343311 6480464 Ethyl Methanesulfonate results in increased expression of SMAD3 mRNA CTD PMID:23649840 fenofibrate multiple interactions ISO RGD:1343311 6480464 Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]; more ... CTD PMID:19593819 fipronil decreases expression EXP 6480464 fipronil results in decreased expression of SMAD3 mRNA CTD PMID:23962444 fluoranthene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of SMAD3 mRNA CTD PMID:18711122 fluoranthene multiple interactions ISO RGD:735647 6480464 [1-methylanthracene co-treated with fluoranthene] results in increased expression of SMAD3 mRNA CTD PMID:28329830 folic acid multiple interactions ISO RGD:735647 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene CTD PMID:20938992 formaldehyde increases expression ISO RGD:1343311 6480464 Formaldehyde results in increased expression of SMAD3 mRNA CTD PMID:23649840 fulvestrant multiple interactions ISO RGD:1343311 6480464 fulvestrant inhibits the reaction [4-nonylphenol results in decreased phosphorylation of SMAD3 protein]; more ... CTD PMID:24308608 PMID:26407941 galangin multiple interactions ISO RGD:1343311 6480464 LY2109761 inhibits the reaction [galangin results in increased phosphorylation of SMAD3 protein] CTD PMID:25268046 galangin increases phosphorylation ISO RGD:1343311 6480464 galangin results in increased phosphorylation of SMAD3 protein CTD PMID:25268046 galangin increases expression ISO RGD:1343311 6480464 galangin results in increased expression of SMAD3 mRNA CTD PMID:25268046 genistein multiple interactions EXP 6480464 Genistein inhibits the reaction [Ethanol results in increased expression of SMAD3 protein]; more ... CTD PMID:23274713 PMID:27876602 genistein multiple interactions ISO RGD:1343311 6480464 Genistein inhibits the reaction [bisphenol A results in decreased phosphorylation of SMAD3 protein]; more ... CTD PMID:26407941 genistein affects response to substance ISO RGD:1343311 6480464 SMAD3 protein affects the susceptibility to Genistein CTD PMID:22228119 genistein decreases expression ISO RGD:1343311 6480464 Genistein results in decreased expression of SMAD3 mRNA; more ... CTD PMID:22228119 glucose multiple interactions ISO RGD:1343311 6480464 C646 compound inhibits the reaction [Glucose results in increased phosphorylation of SMAD3 protein]; more ... CTD PMID:17597607 PMID:26045780 glucose increases phosphorylation ISO RGD:1343311 6480464 Glucose results in increased phosphorylation of SMAD3 protein CTD PMID:26045780 hexachlorobenzene increases phosphorylation ISO RGD:735647 6480464 Hexachlorobenzene results in increased phosphorylation of SMAD3 protein CTD PMID:28923513 hexachlorobenzene multiple interactions ISO RGD:1343311 6480464 AG 1879 inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]; more ... CTD PMID:27519288 Honokiol multiple interactions EXP 6480464 honokiol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21265825 hyaluronic acid multiple interactions ISO RGD:1343311 6480464 [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [FSHB protein results in increased chemical synthesis of Hyaluronic Acid]; more ... CTD PMID:21520325 hydrogen peroxide increases secretion ISO RGD:735647 6480464 Hydrogen Peroxide results in increased secretion of SMAD3 mRNA CTD PMID:21179422 hydrogen peroxide increases phosphorylation ISO RGD:1343311 6480464 Hydrogen Peroxide results in increased phosphorylation of SMAD3 protein CTD PMID:15147944 PMID:24762191 hydrogen peroxide multiple interactions ISO RGD:1343311 6480464 Arsenic Trioxide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of SMAD3 protein]; more ... CTD PMID:24762191 irbesartan multiple interactions EXP 6480464 [benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA; more ... CTD PMID:16635409 irbesartan affects expression EXP 6480464 irbesartan affects the expression of SMAD3 mRNA; more ... CTD PMID:16635409 irinotecan decreases expression ISO RGD:1343311 6480464 Irinotecan analog results in decreased expression of SMAD3 mRNA CTD PMID:18927307 isorhamnetin multiple interactions ISO RGD:1343311 6480464 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; more ... CTD PMID:27151496 L-methionine multiple interactions ISO RGD:735647 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SMAD3 gene; more ... CTD PMID:20938992 PMID:22915297 lead diacetate increases methylation EXP 6480464 lead acetate results in increased methylation of SMAD3 gene CTD PMID:29571894 leptomycin B multiple interactions ISO RGD:735647 6480464 leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; more ... CTD PMID:26354774 linoleic acid decreases abundance ISO RGD:735647 6480464 SMAD3 protein results in decreased abundance of Linoleic Acid CTD PMID:23034213 lipopolysaccharide multiple interactions ISO RGD:735647 6480464 [Lipopolysaccharides results in increased phosphorylation of SMAD3 protein] promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]; more ... CTD PMID:21295571 lipopolysaccharide increases response to substance ISO RGD:735647 6480464 SMAD3 protein results in increased susceptibility to Lipopolysaccharides CTD PMID:21131441 lipopolysaccharide increases phosphorylation ISO RGD:735647 6480464 Lipopolysaccharides results in increased phosphorylation of SMAD3 protein CTD PMID:21295571 lithocholic acid multiple interactions ISO RGD:735647 6480464 SMAD3 protein promotes the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]; more ... CTD PMID:23034213 lithocholic acid increases response to substance ISO RGD:735647 6480464 SMAD3 protein results in increased susceptibility to Lithocholic Acid CTD PMID:23034213 LY 364947 multiple interactions ISO RGD:735647 6480464 Ly-364947 inhibits the reaction [TGFB3 protein results in increased expression of SMAD3 protein modified form] CTD PMID:25566828 lycopene increases expression ISO RGD:1343311 6480464 lycopene results in increased expression of SMAD3 mRNA CTD PMID:16886892 melphalan decreases expression ISO RGD:1343311 6480464 Melphalan results in decreased expression of SMAD3 mRNA CTD PMID:22363485 menadione affects expression ISO RGD:1343311 6480464 Vitamin K 3 affects the expression of SMAD3 mRNA CTD PMID:20044591 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of SMAD3 mRNA CTD PMID:19564919 methamphetamine multiple interactions EXP 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of SMAD3 mRNA CTD PMID:19564919 Methylazoxymethanol acetate increases expression EXP 6480464 Methylazoxymethanol Acetate results in increased expression of SMAD3 mRNA CTD PMID:28349193 methylmercury chloride increases expression ISO RGD:735647 6480464 methylmercuric chloride results in increased expression of SMAD3 mRNA CTD PMID:20061341 methylmercury chloride decreases expression ISO RGD:1343311 6480464 methylmercuric chloride results in decreased expression of SMAD3 mRNA CTD PMID:28001369 mirtazapine multiple interactions ISO RGD:735647 6480464 mirtazapine inhibits the reaction [Thioacetamide results in increased expression of SMAD3 protein modified form] CTD PMID:28623179 N-acetyl-L-cysteine multiple interactions ISO RGD:1343311 6480464 [Acetylcysteine co-treated with Cadmium Chloride co-treated with sodium arsenite] results in decreased expression of SMAD3 mRNA; more ... CTD PMID:21131394 PMID:29408318 N-nitrosodiethylamine multiple interactions EXP 6480464 [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased phosphorylation of SMAD3 protein; more ... CTD PMID:15368444 PMID:19418558 N-nitrosodiethylamine affects phosphorylation EXP 6480464 Diethylnitrosamine affects the phosphorylation of SMAD3 protein CTD PMID:19418558 naringin multiple interactions EXP 6480464 naringin inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA] CTD PMID:27174133 nicotine multiple interactions ISO RGD:735647 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SMAD3 mRNA; more ... CTD PMID:20230807 nicotine multiple interactions EXP 6480464 Nicotine results in increased expression of and results in increased phosphorylation of SMAD3 protein CTD PMID:22691361 nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of SMAD3 mRNA CTD PMID:29660438 nitric oxide multiple interactions EXP 6480464 [SMAD4 protein co-treated with SMAD3 protein] affects the susceptibility to Nitric Oxide; more ... CTD PMID:15949472 nitrofen decreases expression ISO RGD:735647 6480464 nitrofen results in decreased expression of SMAD3 mRNA CTD PMID:12149686 Nonylphenol decreases phosphorylation ISO RGD:1343311 6480464 nonylphenol results in decreased phosphorylation of SMAD3 protein CTD PMID:26407941 Nonylphenol multiple interactions ISO RGD:1343311 6480464 fulvestrant inhibits the reaction [nonylphenol results in decreased phosphorylation of SMAD3 protein]; more ... CTD PMID:26407941 paclitaxel multiple interactions ISO RGD:1343311 6480464 [Cisplatin co-treated with Paclitaxel] results in decreased expression of SMAD3 mRNA CTD PMID:20705681 paracetamol increases expression ISO RGD:735647 6480464 Acetaminophen results in increased expression of SMAD3 mRNA CTD PMID:11752693 paracetamol increases expression ISO RGD:1343311 6480464 Acetaminophen results in increased expression of SMAD3 mRNA CTD PMID:22230336 paracetamol decreases expression ISO RGD:1343311 6480464 Acetaminophen results in decreased expression of SMAD3 mRNA CTD PMID:21420995 paracetamol affects expression ISO RGD:735647 6480464 Acetaminophen affects the expression of SMAD3 mRNA CTD PMID:17562736 paraquat increases response to substance ISO RGD:735647 6480464 SMAD3 protein results in increased susceptibility to Paraquat CTD PMID:22581813 paraquat increases expression ISO RGD:1343311 6480464 Paraquat results in increased expression of SMAD3 protein modified form CTD PMID:27682480 paraquat multiple interactions ISO RGD:1343311 6480464 TGFB1 protein promotes the reaction [Paraquat results in increased expression of SMAD3 protein modified form] CTD PMID:27682480 perindopril multiple interactions EXP 6480464 Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] CTD PMID:16872305 perindopril decreases expression EXP 6480464 Perindopril results in decreased expression of SMAD3 protein CTD PMID:15619341 phloroglucinol multiple interactions ISO RGD:1343311 6480464 Phloroglucinol analog inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:26054450 picrotoxin increases expression EXP 6480464 Picrotoxin results in increased expression of SMAD3 mRNA CTD PMID:15170462 pirinixic acid decreases expression ISO RGD:735647 6480464 pirinixic acid results in decreased expression of SMAD3 mRNA CTD PMID:20813756 potassium chromate multiple interactions ISO RGD:1343311 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SMAD3 mRNA CTD PMID:22079256 potassium chromate decreases expression ISO RGD:1343311 6480464 potassium chromate(VI) results in decreased expression of SMAD3 mRNA CTD PMID:22079256 PMID:22714537 progesterone multiple interactions ISO RGD:1343311 6480464 [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] promotes the reaction [FSHB protein results in increased chemical synthesis of Progesterone]; more ... CTD PMID:20660070 PMID:21520325 progesterone decreases expression ISO RGD:1343311 6480464 Progesterone results in decreased expression of SMAD3 mRNA CTD PMID:20864642 quercetin multiple interactions ISO RGD:1343311 6480464 Quercetin inhibits the reaction [SMAD2 protein modified form binds to SMAD3 protein modified form binds to SMAD4 protein] CTD PMID:15580028 quercetin multiple interactions ISO RGD:735647 6480464 Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SMAD3 mRNA]; more ... CTD PMID:21216973 PMID:22915297 quercetin decreases expression ISO RGD:1343311 6480464 Quercetin results in decreased expression of SMAD3 protein; more ... CTD PMID:15580028 quercitrin increases expression ISO RGD:1343311 6480464 quercitrin results in increased expression of SMAD3 mRNA CTD PMID:25193878 reactive oxygen species affects expression ISO RGD:1343311 6480464 Reactive Oxygen Species affects the expression of SMAD3 mRNA CTD PMID:25800948 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD3 protein] CTD PMID:21300041 resveratrol multiple interactions ISO RGD:1343311 6480464 resveratrol inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:27345520 resveratrol multiple interactions ISO RGD:735647 6480464 resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of SMAD3 protein] CTD PMID:25234611 resveratrol decreases expression ISO RGD:1343311 6480464 resveratrol results in decreased expression of SMAD3 mRNA; more ... CTD PMID:18089832 PMID:25721869 resveratrol decreases acetylation EXP 6480464 resveratrol results in decreased acetylation of SMAD3 protein CTD PMID:20651248 resveratrol decreases acetylation ISO RGD:735647 6480464 resveratrol results in decreased acetylation of SMAD3 protein CTD PMID:20651248 resveratrol decreases phosphorylation ISO RGD:735647 6480464 resveratrol results in decreased phosphorylation of SMAD3 protein CTD PMID:21679764 SB 203580 multiple interactions ISO RGD:1343311 6480464 SB 203580 inhibits the reaction [TGFB2 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:18253093 SB 431542 decreases phosphorylation EXP 6480464 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased phosphorylation of SMAD3 protein CTD PMID:28982980 SB 431542 multiple interactions ISO RGD:735647 6480464 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Sodium Fluoride results in increased expression of SMAD3 mRNA]; more ... CTD PMID:21586554 PMID:29127033 SB 431542 multiple interactions ISO RGD:1343311 6480464 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; more ... CTD PMID:21520325 PMID:28871336 SB 431542 decreases phosphorylation ISO RGD:735647 6480464 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased phosphorylation of SMAD3 protein CTD PMID:29127033 SB 431542 multiple interactions EXP 6480464 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Carbofuran results in increased phosphorylation of SMAD3 protein] CTD PMID:28982980 SCH 23390 increases expression EXP 6480464 SCH 23390 results in increased expression of SMAD3 mRNA CTD PMID:19564919 SCH 23390 multiple interactions EXP 6480464 [Methamphetamine co-treated with SCH 23390] results in increased expression of SMAD3 mRNA CTD PMID:19564919 serpentine asbestos multiple interactions ISO RGD:1343311 6480464 [Asbestos, Serpentine results in decreased susceptibility to Asbestos] which results in decreased expression of and results in increased phosphorylation of SMAD3 protein; more ... CTD PMID:25358858 sevoflurane multiple interactions ISO RGD:735647 6480464 TGFB1 protein affects the reaction [sevoflurane affects the localization of SMAD3 protein] CTD PMID:18434384 sevoflurane affects response to substance ISO RGD:735647 6480464 SMAD3 protein affects the susceptibility to sevoflurane CTD PMID:18434384 silver atom increases expression ISO RGD:1343311 6480464 Silver results in increased expression of SMAD3 mRNA CTD PMID:28959546 silver(0) increases expression ISO RGD:1343311 6480464 Silver results in increased expression of SMAD3 mRNA CTD PMID:28959546 silver(1+) increases expression ISO RGD:1343311 6480464 Silver results in increased expression of SMAD3 mRNA CTD PMID:28959546 silver(1+) nitrate decreases expression ISO RGD:1343311 6480464 Silver Nitrate analog results in decreased expression of SMAD3 mRNA CTD PMID:22831968 silver(1+) nitrate increases expression ISO RGD:1343311 6480464 Silver Nitrate results in increased expression of SMAD3 mRNA CTD PMID:22831968 simvastatin increases expression ISO RGD:735647 6480464 Simvastatin results in increased expression of SMAD3 mRNA CTD PMID:18310456 simvastatin decreases phosphorylation EXP 6480464 Simvastatin results in decreased phosphorylation of SMAD3 protein CTD PMID:19659652 sodium arsenate increases expression ISO RGD:735647 6480464 sodium arsenate results in increased expression of SMAD3 mRNA CTD PMID:21795629 sodium arsenite multiple interactions ISO RGD:735647 6480464 IFNG protein inhibits the reaction [sodium arsenite results in increased expression of and results in increased phosphorylation of SMAD3 protein]; more ... CTD PMID:17003472 PMID:23732083 sodium arsenite multiple interactions ISO RGD:1343311 6480464 [Acetylcysteine co-treated with Cadmium Chloride co-treated with sodium arsenite] results in decreased expression of SMAD3 mRNA CTD PMID:29408318 sodium arsenite increases phosphorylation EXP 6480464 sodium arsenite results in increased phosphorylation of SMAD3 protein CTD PMID:21605584 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of SMAD3 mRNA; more ... CTD PMID:27174133 PMID:27889505 sodium arsenite multiple interactions EXP 6480464 candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD3 protein modified form]; more ... CTD PMID:21605584 more ... sodium arsenite decreases phosphorylation ISO RGD:735647 6480464 sodium arsenite results in decreased phosphorylation of SMAD3 protein CTD PMID:23732083 sodium fluoride increases expression ISO RGD:735647 6480464 Sodium Fluoride results in increased expression of SMAD3 mRNA CTD PMID:29127033 sodium fluoride multiple interactions ISO RGD:735647 6480464 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Sodium Fluoride results in increased expression of SMAD3 mRNA]; more ... CTD PMID:29127033 sorafenib affects localization ISO RGD:735647 6480464 sorafenib affects the localization of SMAD3 protein CTD PMID:21360571 sorafenib multiple interactions ISO RGD:735647 6480464 sorafenib inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein] CTD PMID:21360571 streptozocin multiple interactions EXP 6480464 resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD3 protein] CTD PMID:21300041 streptozocin increases phosphorylation EXP 6480464 Streptozocin results in increased phosphorylation of SMAD3 protein CTD PMID:21300041 tamoxifen multiple interactions ISO RGD:1343311 6480464 Tamoxifen promotes the reaction [Tretinoin results in increased phosphorylation of SMAD3 protein] CTD PMID:17098229 tamoxifen increases phosphorylation ISO RGD:1343311 6480464 Tamoxifen results in increased phosphorylation of SMAD3 protein CTD PMID:17098229 tauro-beta-muricholic acid increases abundance ISO RGD:735647 6480464 SMAD3 protein results in increased abundance of tauromuricholic acid CTD PMID:23034213 taurochenodeoxycholic acid increases abundance ISO RGD:735647 6480464 SMAD3 protein results in increased abundance of Taurochenodeoxycholic Acid CTD PMID:23034213 taurolithocholic acid increases abundance ISO RGD:735647 6480464 SMAD3 protein results in increased abundance of Taurolithocholic Acid CTD PMID:23034213 tauroursodeoxycholic acid increases abundance ISO RGD:735647 6480464 SMAD3 protein results in increased abundance of tauroursodeoxycholic acid CTD PMID:23034213 tert-butyl hydroperoxide increases expression ISO RGD:1343311 6480464 tert-Butylhydroperoxide results in increased expression of SMAD3 mRNA CTD PMID:27509014 tert-butyl hydroperoxide increases methylation ISO RGD:1343311 6480464 tert-Butylhydroperoxide results in increased methylation of SMAD3 gene CTD PMID:27509014 Tesaglitazar decreases expression EXP 6480464 tesaglitazar results in decreased expression of SMAD3 mRNA CTD PMID:21515302 testosterone increases expression ISO RGD:735647 6480464 Testosterone results in increased expression of SMAD3 mRNA CTD PMID:22138414 tetrachloromethane increases phosphorylation EXP 6480464 Carbon Tetrachloride results in increased phosphorylation of SMAD3 protein CTD PMID:24211420 PMID:25150141 tetrachloromethane increases expression ISO RGD:735647 6480464 Carbon Tetrachloride results in increased expression of SMAD3 mRNA CTD PMID:18395914 PMID:26297989 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of SMAD3 mRNA; more ... CTD PMID:15818738 more ... tetrachloromethane multiple interactions EXP 6480464 Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 mRNA]; more ... CTD PMID:15818738 more ... tetrachloromethane increases activity EXP 6480464 Carbon Tetrachloride results in increased activity of SMAD3 protein CTD PMID:17009398 tetrachloromethane affects response to substance ISO RGD:735647 6480464 SMAD3 protein affects the susceptibility to Carbon Tetrachloride CTD PMID:16382155 tetrachloromethane multiple interactions ISO RGD:735647 6480464 Carbon Tetrachloride inhibits the reaction [HGF protein affects the localization of SMAD3 protein]; more ... CTD PMID:18395096 more ... thioacetamide multiple interactions ISO RGD:735647 6480464 mirtazapine inhibits the reaction [Thioacetamide results in increased expression of SMAD3 protein modified form] CTD PMID:28623179 thioacetamide increases expression ISO RGD:735647 6480464 Thioacetamide results in increased expression of SMAD3 protein modified form CTD PMID:28623179 trichostatin A affects expression ISO RGD:1343311 6480464 trichostatin A affects the expression of SMAD3 mRNA CTD PMID:28542535 troglitazone multiple interactions ISO RGD:1343311 6480464 troglitazone inhibits the reaction [TGFB2 protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:18253093 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of SMAD3 mRNA CTD PMID:21515302 ursodeoxycholic acid decreases expression EXP 6480464 Ursodeoxycholic Acid results in decreased expression of SMAD3 mRNA; more ... CTD PMID:19493473 valproic acid increases methylation ISO RGD:1343311 6480464 Valproic Acid results in increased methylation of SMAD3 gene CTD PMID:28853863 more ... valproic acid decreases expression ISO RGD:1343311 6480464 Valproic Acid results in decreased expression of SMAD3 mRNA; more ... CTD PMID:29501571 valsartan multiple interactions EXP 6480464 Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein] CTD PMID:16872305 valsartan decreases expression EXP 6480464 Valsartan results in decreased expression of SMAD3 protein CTD PMID:15619341 Verbascoside increases phosphorylation ISO RGD:1343311 6480464 acteoside results in increased phosphorylation of SMAD3 protein CTD PMID:17634406 vitamin E increases expression ISO RGD:1343311 6480464 Vitamin E results in increased expression of SMAD3 mRNA CTD PMID:19244175 zinc atom multiple interactions ISO RGD:735647 6480464 Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; more ... CTD PMID:22228435 PMID:26354774 zinc(0) multiple interactions ISO RGD:735647 6480464 Zinc inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; more ... CTD PMID:22228435 PMID:26354774 zoledronic acid increases expression ISO RGD:1343311 6480464 zoledronic acid results in increased expression of SMAD3 mRNA CTD PMID:24714768 zoledronic acid increases phosphorylation ISO RGD:1343311 6480464 zoledronic acid results in increased phosphorylation of SMAD3 protein CTD PMID:28871336 zoledronic acid increases phosphorylation ISO RGD:735647 6480464 zoledronic acid results in increased phosphorylation of SMAD3 protein CTD PMID:28871336 zoledronic acid multiple interactions ISO RGD:1343311 6480464 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [zoledronic acid results in increased phosphorylation of SMAD3 protein] CTD PMID:28871336 zoledronic acid increases phosphorylation EXP 6480464 zoledronic acid results in increased phosphorylation of SMAD3 protein CTD PMID:28871336
Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process ISO RGD:1343311 1624291 RGD PMID:15107418 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP 2301029 TGF-beta1-induced cleavage of BAD to its more active 15 kD form RGD activin receptor signaling pathway ISO RGD:1343311 1624291 RGD PMID:15150278 adrenal gland development IDA 728125 RGD cell cycle arrest ISO RGD:1343311 1624291 RGD PMID:14555988 cell cycle arrest IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cell-cell junction organization ISO RGD:1343311 1624291 RGD PMID:18505915 cell-cell junction organization IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to transforming growth factor beta stimulus ISO RGD:1343311 1624291 RGD PMID:12902338 developmental growth ISO RGD:735647 1624291 MGI:MGI:108051 RGD MGI:MGI:3618021 PMID:15183723 developmental growth IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic cranial skeleton morphogenesis ISO RGD:735647 1624291 MGI:MGI:108051 RGD MGI:MGI:3618021 PMID:15183723 embryonic cranial skeleton morphogenesis IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic foregut morphogenesis ISO RGD:735647 1624291 MGI:MGI:108051 RGD MGI:MGI:3618021 PMID:15183723 embryonic foregut morphogenesis IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 embryonic pattern specification ISO RGD:735647 1624291 MGI:MGI:108051 RGD MGI:MGI:3618021 PMID:15183723 embryonic pattern specification IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 endoderm development ISO RGD:735647 1624291 MGI:MGI:108051 RGD MGI:MGI:3618021 PMID:15183723 endoderm development IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 evasion or tolerance of host defenses by virus ISO RGD:1343311 1624291 RGD PMID:15334054 evasion or tolerance of host defenses by virus IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 extrinsic apoptotic signaling pathway ISO RGD:1343311 1624291 RGD PMID:15334054 extrinsic apoptotic signaling pathway IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 gastrulation ISO RGD:735647 1624291 MGI:MGI:108051 RGD MGI:MGI:3618021 PMID:15183723 heart looping ISO RGD:735647 1624291 MGI:MGI:108051 RGD MGI:MGI:3618021 PMID:15183723 heart looping IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 immune response ISO RGD:1343311 1624291 RGD PMID:16886151 immune response IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 immune system development ISO RGD:735647 1624291 MGI:MGI:108051 RGD MGI:MGI:3618021 PMID:15183723 immune system development IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 in utero embryonic development ISO RGD:735647 1624291 MGI:MGI:108051 RGD MGI:MGI:3618021 PMID:15183723 in utero embryonic development IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 lens fiber cell differentiation ISO RGD:735647 1624291 RGD MGI:MGI:3720408 PMID:17215516 lens fiber cell differentiation IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 liver development ISO RGD:735647 1624291 MGI:MGI:108051 RGD MGI:MGI:3618021 PMID:15183723 liver development IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 mesoderm formation ISO RGD:735647 1624291 MGI:MGI:1857696 RGD MGI:MGI:3039049 PMID:15084457 mesoderm formation IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of apoptotic process IDA 2300426 osteoblastic UMR-106 cells RGD negative regulation of cardiac muscle hypertrophy in response to stress IGI RNAcentral:URS0000554A4F_10116 11535100 PMID:27038547 BHF-UCL negative regulation of cell growth ISO RGD:1343311 1624291 RGD PMID:8774881 negative regulation of cell growth IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cell population proliferation IDA 2300418 RGD negative regulation of cytosolic calcium ion concentration ISO RGD:1343311 1624291 RGD PMID:27038547 negative regulation of cytosolic calcium ion concentration IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of fat cell differentiation ISO RGD:1343311 1624291 RGD PMID:19816956 negative regulation of fat cell differentiation IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of inflammatory response ISO RGD:735647 1624291 RGD MGI:MGI:1352043 PMID:10559937 negative regulation of inflammatory response IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of lung blood pressure IGI RNAcentral:URS0000554A4F_10116 11535100 PMID:27038547 BHF-UCL negative regulation of mitotic cell cycle ISO RGD:1343311 1624291 RGD PMID:14555988 negative regulation of mitotic cell cycle IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of osteoblast differentiation ISO RGD:735647 1624291 MGI:MGI:1316736 RGD MGI:MGI:3056877 PMID:15150273 negative regulation of osteoblast differentiation IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of osteoblast proliferation ISO RGD:735647 1624291 RGD MGI:MGI:5285145 PMID:21035443 negative regulation of osteoblast proliferation IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of protein catabolic process IMP 11079190 PMID:20097766 BHF-UCL negative regulation of transcription by RNA polymerase II IMP 2300406 rat Tert gene RGD negative regulation of transcription by RNA polymerase II ISO RGD:735647 1624291 RGD MGI:MGI:1276222 more ... negative regulation of transcription by RNA polymerase II ISO RGD:1343311 1624291 RGD PMID:14555988 PMID:8774881 negative regulation of wound healing ISO RGD:735647 1624291 RGD MGI:MGI:1352043 more ... negative regulation of wound healing IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 nodal signaling pathway ISO RGD:1343311 1624291 RGD PMID:15150278 nodal signaling pathway IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 osteoblast development ISO RGD:735647 1624291 MGI:MGI:1316736 RGD MGI:MGI:3056877 PMID:15150273 osteoblast development IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 osteoblast differentiation ISO RGD:735647 1624291 RGD MGI:MGI:3654245 PMID:11585338 paraxial mesoderm morphogenesis ISO RGD:735647 1624291 MGI:MGI:1857696 RGD MGI:MGI:3039049 PMID:15084457 paraxial mesoderm morphogenesis IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 pericardium development ISO RGD:735647 1624291 MGI:MGI:108051 RGD MGI:MGI:3618021 PMID:15183723 pericardium development IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of alkaline phosphatase activity IDA 727387 rat gene expressed in mouse osteoblastic cell line MC3T3-E1; more ... RGD positive regulation of bone mineralization IDA 727387 rat gene expressed in mouse osteoblastic cell line MC3T3-E1; more ... RGD positive regulation of canonical Wnt signaling pathway IMP 11079190 PMID:20097766 BHF-UCL positive regulation of cell migration IMP 2300403 transformed cells in culture RGD positive regulation of chondrocyte differentiation ISO RGD:735647 1624291 RGD MGI:MGI:5285145 PMID:21035443 positive regulation of chondrocyte differentiation IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of epithelial to mesenchymal transition ISO RGD:1343311 1624291 RGD PMID:18505915 PMID:21307346 positive regulation of epithelial to mesenchymal transition IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of extracellular matrix assembly ISO RGD:1343311 1624291 RGD PMID:21307346 positive regulation of extracellular matrix assembly IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of focal adhesion assembly IDA 2300418 RGD positive regulation of gene expression ISO RGD:1343311 1624291 RGD PMID:21307346 positive regulation of interleukin-1 beta production IMP 2300404 TGFbeta-1 dependent, in pancreatic stellate cells RGD positive regulation of nitric oxide biosynthetic process IGI RNAcentral:URS0000554A4F_10116 11535100 PMID:27038547 BHF-UCL positive regulation of nitric oxide biosynthetic process ISO RGD:1343311 1624291 RGD PMID:27038547 positive regulation of positive chemotaxis IDA 2300418 Hepatic stellate cells; more ... RGD positive regulation of pri-miRNA transcription by RNA polymerase II ISO RGD:1343311 1624291 RGD PMID:26311719 positive regulation of pri-miRNA transcription by RNA polymerase II IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of stress fiber assembly IDA 2300418 during transdifferentiation RGD positive regulation of transcription by RNA polymerase II IDA 1299323 alpha-smooth muscle actin in lung fibroblasts RGD positive regulation of transcription by RNA polymerase II ISO RGD:735647 1624291 MGI:MGI:106658|MGI:MGI:108051|MGI:MGI:1314872|MGI:MGI:1316736|MGI:MGI:1344313|MGI:MGI:894293|MGI:MGI:98727 RGD MGI:MGI:2675699 more ... positive regulation of transcription by RNA polymerase II ISO RGD:1343311 1624291 RGD PMID:14555988 more ... positive regulation of transcription by RNA polymerase II IMP 8554355 PMID:22073128 BHF-UCL positive regulation of transcription by RNA polymerase II IMP 1625706 RGD positive regulation of transcription, DNA-templated ISO RGD:735647 1624291 RGD MGI:MGI:3056014 more ... positive regulation of transcription, DNA-templated ISO RGD:1343311 1624291 RGD PMID:9111321 more ... positive regulation of transforming growth factor beta3 production IMP 1625706 RGD protein stabilization IMP 11079190 PMID:20097766 BHF-UCL regulation of binding ISO RGD:735647 1624291 RGD MGI:MGI:3513643 PMID:15282343 regulation of binding IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of epithelial cell proliferation ISO RGD:735647 1624291 MGI:MGI:1857695 RGD MGI:MGI:3617027 PMID:12845704 regulation of epithelial cell proliferation IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of immune response ISO RGD:735647 1624291 RGD MGI:MGI:1332876 PMID:10064594 regulation of immune response IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of striated muscle tissue development ISO RGD:735647 1624291 RGD MGI:MGI:2153314 PMID:11711431 regulation of striated muscle tissue development IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of transcription by RNA polymerase II ISO RGD:1343311 1624291 RGD PMID:21947082 regulation of transforming growth factor beta receptor signaling pathway ISO RGD:735647 1624291 RGD MGI:MGI:2153314 PMID:11711431 regulation of transforming growth factor beta receptor signaling pathway IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of transforming growth factor beta receptor signaling pathway IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of transforming growth factor beta receptor signaling pathway ISO RGD:1343311 1624291 RGD PMID:8774881 regulation of transforming growth factor beta2 production ISO RGD:1343311 1624291 RGD PMID:12411310 regulation of transforming growth factor beta2 production IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to hypoxia ISO RGD:1343311 1624291 RGD PMID:12411310 response to hypoxia IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 signal transduction involved in regulation of gene expression IMP 8554355 PMID:22073128 BHF-UCL skeletal system development ISO RGD:735647 1624291 MGI:MGI:108051 RGD MGI:MGI:3618021 PMID:15183723 SMAD protein complex assembly IPI RGD:3033 RGD:2401 1599906 RGD SMAD protein complex assembly ISO RGD:1343311 1624291 RGD PMID:10823886 PMID:9111321 SMAD protein signal transduction ISO RGD:735647 1624291 MGI:MGI:108051 RGD MGI:MGI:5486383 PMID:23390484 SMAD protein signal transduction IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 somitogenesis ISO RGD:735647 1624291 MGI:MGI:108051 RGD MGI:MGI:3618021 PMID:15183723 somitogenesis IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 T cell activation ISO RGD:735647 1624291 RGD MGI:MGI:1332876 PMID:10064594 T cell activation IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 thyroid gland development ISO RGD:735647 1624291 MGI:MGI:108051 RGD MGI:MGI:3618021 PMID:15183723 thyroid gland development IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 transdifferentiation IDA 2300418 quiescent hepatic stellate cells to myofibroblasts RGD transforming growth factor beta receptor signaling pathway IMP 1625706 RGD transforming growth factor beta receptor signaling pathway ISO RGD:1343311 1624291 RGD PMID:18548003 more ... transforming growth factor beta receptor signaling pathway ISO RGD:735647 1624291 RGD MGI:MGI:3505646 more ... transforming growth factor beta receptor signaling pathway IMP 8554355 PMID:22073128 BHF-UCL transforming growth factor beta receptor signaling pathway IMP 2300404 TGFbeta-1 dependent, in pancreatic stellate cells RGD ureteric bud development ISO RGD:735647 1624291 RGD PMID:14656760 ureteric bud development IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component cytoplasm IDA 2300403 RGD cytoplasm ISO RGD:735647 1624291 RGD MGI:MGI:5009194 PMID:11160896 cytoplasm ISO RGD:1343311 1624291 RGD PMID:12446380 more ... cytosol IEA UniProtKB:A0A024R5Z3|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:1343311 1624291 RGD GO_REF:0000052 cytosol IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 heteromeric SMAD protein complex ISO RGD:1343311 1624291 RGD PMID:21828274 heteromeric SMAD protein complex IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 nuclear chromatin ISO RGD:1343311 1624291 RGD PMID:21828274 nuclear chromatin IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 nuclear inner membrane ISO RGD:1343311 1624291 RGD PMID:15647271 nuclear inner membrane IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm ISO RGD:1343311 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm IEA UniProtKB:A0A024R5Z3|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus IDA 1599906 RGD nucleus ISO RGD:735647 1624291 RGD MGI:MGI:2675699 more ... nucleus ISO RGD:1343311 1624291 RGD PMID:12446380 more ... nucleus IDA 8554355 PMID:22073128 BHF-UCL nucleus IDA 2300403 RGD plasma membrane ISO RGD:735647 1624291 RGD MGI:MGI:2449899 PMID:12543979 plasma membrane IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein-containing complex IDA 1599906 RGD receptor complex ISO RGD:1343311 1624291 RGD PMID:8774881 receptor complex IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 SMAD protein complex ISO RGD:1343311 1624291 RGD PMID:18832382 PMID:21947082 SMAD protein complex ISS UniProtKB:P84022 1600115 GO_REF:0000024 UniProt GO_REF:0000024 transcription factor complex IDA 1625706 RGD transcription factor complex ISO RGD:1343311 1624291 RGD PMID:21947082 Molecular Function beta-catenin binding IDA 11079190 PMID:20097766 BHF-UCL bHLH transcription factor binding ISO RGD:1343311 1624291 UniProtKB:Q99081 RGD PMID:21828274 bHLH transcription factor binding IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 chromatin binding ISO RGD:735647 1624291 RGD MGI:MGI:3690196 PMID:16619037 chromatin DNA binding ISO RGD:735647 1624291 RGD MGI:MGI:3696631 PMID:16224064 chromatin DNA binding IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 co-SMAD binding ISO RGD:1343311 1624291 UniProtKB:Q13485 RGD PMID:8774881 more ... co-SMAD binding IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 collagen binding ISO RGD:735647 1624291 UniProtKB:P08121|UniProtKB:Q01149|UniProtKB:Q3U962 RGD MGI:MGI:2679769 PMID:14559231 collagen binding IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 DEAD/H-box RNA helicase binding ISO RGD:1343311 1624291 UniProtKB:P17844 RGD PMID:18548003 DEAD/H-box RNA helicase binding IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA binding IDA 1599906 RGD DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:1343311 1624291 RGD PMID:26311719 DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:735647 1624291 ENSEMBL_GeneID:ENSG00000127445 RGD MGI:MGI:6158712 PMID:24964035 DNA-binding transcription activator activity, RNA polymerase II-specific IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA-binding transcription activator activity, RNA polymerase II-specific IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA-binding transcription factor activity IDA 1299323 RGD DNA-binding transcription factor activity ISO RGD:1343311 1624291 RGD PMID:10823886 more ... DNA-binding transcription factor activity contributes_to ISO RGD:1343311 1624291 RGD PMID:9111321 DNA-binding transcription factor activity ISO RGD:735647 1624291 RGD MGI:MGI:2675699 PMID:12943993 DNA-binding transcription factor activity, RNA polymerase II-specific ISO RGD:1343311 1624291 RGD PMID:21947082 double-stranded DNA binding ISO RGD:735647 1624291 RGD MGI:MGI:3513643 PMID:15282343 enzyme binding IPI RGD:2053 8554355 RGD enzyme binding IPI UniProtKB:P27008 8554355 PMID:22073128 BHF-UCL glucocorticoid receptor binding ISO RGD:1343311 1624291 UniProtKB:P04150 RGD PMID:12902338 glucocorticoid receptor binding IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 identical protein binding ISO RGD:1343311 1624291 UniProtKB:P84022 RGD PMID:18729074 PMID:22045334 mineralocorticoid receptor binding ISO RGD:1343311 1624291 UniProtKB:P22199 RGD PMID:12902338 mineralocorticoid receptor binding IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 phosphatase binding ISO RGD:1343311 1624291 UniProtKB:P35813 RGD PMID:16751101 phosphatase binding IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 primary miRNA binding ISO RGD:1343311 1624291 RNAcentral:URS000018AA08_9606 RGD PMID:18548003 primary miRNA binding IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding IPI RGD:2401 1599906 RGD protein binding IPI UniProtKB:P47196 8553856 PMID:16362038 IntAct protein binding ISO RGD:735647 1624291 RefSeq:NP_081780|UniProtKB:A7M7C7|UniProtKB:O35295|UniProtKB:O35625|UniProtKB:O70477|UniProtKB:O88559|UniProtKB:O95551|UniProtKB:P10085|UniProtKB:P20263|UniProtKB:P41778|UniProtKB:P42669|UniProtKB:P70435|UniProtKB:P97471|UniProtKB:Q08775|UniProtKB:Q15327|UniProtKB:Q61656|UniProtKB:Q6NZM9|UniProtKB:Q6PGA9|UniProtKB:Q8VIM5|UniProtKB:Q9DBX1|UniProtKB:Q9Z2V6 RGD MGI:MGI:2153314 more ... protein binding IPI UniProtKB:O35740 8554622 PMID:16619037 UniProt protein binding ISO RGD:1343311 1624291 UniProtKB:O00255|UniProtKB:O00308|UniProtKB:O15165|UniProtKB:O43186|UniProtKB:O43524|UniProtKB:O75593|UniProtKB:O92972:PRO_0000278742|UniProtKB:O95405|UniProtKB:P08238|UniProtKB:P0DMV8|UniProtKB:P0DOE7|UniProtKB:P10070|UniProtKB:P12755|UniProtKB:P12757-1|UniProtKB:P17844|UniProtKB:P36896|UniProtKB:P50222|UniProtKB:P52926|UniProtKB:P84022|UniProtKB:P84550|UniProtKB:P98082|UniProtKB:Q03112-1|UniProtKB:Q08117|UniProtKB:Q08117-2|UniProtKB:Q09472|UniProtKB:Q13485|UniProtKB:Q13501|UniProtKB:Q13526|UniProtKB:Q13547|UniProtKB:Q13573|UniProtKB:Q15796|UniProtKB:Q16665|UniProtKB:Q16822|UniProtKB:Q2VWA4|UniProtKB:Q5D1E8|UniProtKB:Q64729|UniProtKB:Q8IXK0|UniProtKB:Q8IXK0-5|UniProtKB:Q8N684|UniProtKB:Q8N684-3|UniProtKB:Q8N6I1|UniProtKB:Q8WW24|UniProtKB:Q93009|UniProtKB:Q93062|UniProtKB:Q96EP0|UniProtKB:Q99814|UniProtKB:Q99836|UniProtKB:Q9BYW2|UniProtKB:Q9BZ29|UniProtKB:Q9BZL4|UniProtKB:Q9GZV5|UniProtKB:Q9H0M0|UniProtKB:Q9H2G9|UniProtKB:Q9H2X0|UniProtKB:Q9H4X1|UniProtKB:Q9H6Z4|UniProtKB:Q9HAU4|UniProtKB:Q9HAZ2|UniProtKB:Q9NRR4|UniProtKB:Q9NYA4|UniProtKB:Q9UNE7|UniProtKB:Q9WVQ1|UniProtKB:Q9Y2U8|UniProtKB:Q9Y3Q8|UniProtKB:Q9Y4E8 RGD PMID:10681527 more ... protein heterodimerization activity ISO RGD:735647 1624291 RGD MGI:MGI:5317378 PMID:21724602 protein heterodimerization activity IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein homodimerization activity ISO RGD:735647 1624291 RGD MGI:MGI:5317378 PMID:21724602 protein homodimerization activity IEA UniProtKB:Q8BUN5|ensembl:ENSMUSP00000034973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein homodimerization activity IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein homodimerization activity ISO RGD:1343311 1624291 UniProtKB:P84022 RGD PMID:8774881 protein kinase binding ISO RGD:1343311 1624291 UniProtKB:Q9H2X6 RGD PMID:12874272 protein kinase binding IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 proximal promoter sequence-specific DNA binding ISO RGD:1343311 1624291 RGD PMID:18832382 PMID:21947082 proximal promoter sequence-specific DNA binding ISS UniProtKB:P84022 1600115 GO_REF:0000024 UniProt GO_REF:0000024 R-SMAD binding ISO RGD:1343311 1624291 UniProtKB:P84022|UniProtKB:Q15796 RGD PMID:20129061 PMID:9311995 R-SMAD binding IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 RNA polymerase II activating transcription factor binding ISO RGD:1343311 1624291 UniProtKB:P26367 RGD PMID:17251190 RNA polymerase II activating transcription factor binding IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 RNA polymerase II proximal promoter sequence-specific DNA binding ISO RGD:1343311 1624291 RGD PMID:21947082 RNA polymerase II proximal promoter sequence-specific DNA binding IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 RNA polymerase II regulatory region sequence-specific DNA binding ISO RGD:735647 1624291 RGD MGI:MGI:5688819 PMID:25065622 sequence-specific DNA binding IDA 1299323 Smad binding elements SBE1 and SBE2 in alpha-smooth muscle actin promoter RGD sequence-specific DNA binding ISO RGD:1343311 1624291 RGD PMID:10823886 sequence-specific DNA binding IDA 8554355 PMID:22073128 BHF-UCL sequence-specific DNA binding IDA 2300406 Smad binding element (SBE) in the rat Tert gene promoter RGD sequence-specific DNA binding IDA 1625706 RGD SMAD binding IPI RGD:3033 1599906 RGD transcription coregulator activity IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription coregulator activity ISO RGD:1343311 1624291 RGD PMID:18832382 transcription factor binding IPI RGD:620036 2301880 RGD transcription factor binding ISO RGD:735647 1624291 UniProtKB:B7ZQJ9 RGD MGI:MGI:4399035 PMID:11937490 transcription factor binding ISO RGD:1343311 1624291 UniProtKB:O75593|UniProtKB:P01100|UniProtKB:P05412 RGD PMID:21828274 PMID:9732876 transcription factor binding IDA 2300420 recombinant Klf4, unknown species RGD transcription regulatory region DNA binding ISO RGD:1343311 1624291 RGD PMID:9732876 transforming growth factor beta receptor binding ISO RGD:1343311 1624291 UniProtKB:P36897 RGD PMID:9311995 transforming growth factor beta receptor binding IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ISO RGD:1343311 1624291 RGD PMID:9111321 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ubiquitin binding ISO RGD:1343311 1624291 RGD PMID:18794808 ubiquitin binding IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 ubiquitin protein ligase binding ISO RGD:1343311 1624291 UniProtKB:Q9HAU4|UniProtKB:Q9HCE7 RGD PMID:11278251 PMID:19122240 ubiquitin protein ligase binding IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 zinc ion binding ISO RGD:1343311 1624291 RGD PMID:12686552 zinc ion binding IEA UniProtKB:P84022|ensembl:ENSP00000332973 1600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
