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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad3
Name: SMAD family member 3
Acc ID: CHEBI:137064
Term: LY-2157299
Definition: A pyrrolopyrazole that is 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole which is substituted at positions 2 and 3 by 6-methylpyridin-2-yl and 6-(aminocarbonyl)quinolin-4-yl groups, respectively. A Transforming growth factor-betaRI (TGF-betaRI) kinase inhibitor, it blocks TGF-beta-mediated tumor growth in glioblastoma.
Chemical ID: MESH:C557799
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad3multiple interactionsEXP 6480464CTDLY-2157299 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]PMID:35122773
Smad3multiple interactionsISOSMAD3 (Homo sapiens)6480464CTDLY-2157299 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]PMID:35122773
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