RGD Reference Report - Mechanisms of TGF-beta signaling from cell membrane to the nucleus. - Rat Genome Database

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus.

Authors: Shi, Y  Massague, J 
Citation: Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
RGD ID: 2298922
Pubmed: PMID:12809600   (View Abstract at PubMed)

TGF-beta signaling controls a plethora of cellular responses and figures prominently in animal development. Recent cellular, biochemical, and structural studies have revealed significant insight into the mechanisms of the activation of TGF-beta receptors through ligand binding, the activation of Smad proteins through phosphorylation, the transcriptional regulation of target gene expression, and the control of Smad protein activity and degradation. This article reviews these latest advances and presents our current understanding on the mechanisms of TGF-beta signaling from cell membrane to the nucleus.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
A2MHumantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
A2mRattransforming growth factor-beta Smad dependent signaling pathway   IMPA2M (Homo sapiens) RGD 
A2mMousetransforming growth factor-beta Smad dependent signaling pathway   IMPA2M (Homo sapiens) RGD 
DCNHumantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
DcnRattransforming growth factor-beta Smad dependent signaling pathway   ISODCN (Homo sapiens) RGD 
DcnMousetransforming growth factor-beta Smad dependent signaling pathway   ISODCN (Homo sapiens) RGD 
FKBP1AHumantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
Fkbp1aRattransforming growth factor-beta Smad dependent signaling pathway   ISOFKBP1A (Homo sapiens) RGD 
Fkbp1aMousetransforming growth factor-beta Smad dependent signaling pathway   ISOFKBP1A (Homo sapiens) RGD 
SMAD2Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
SMAD3Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
SMAD4Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
SMAD7Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
SMURF1Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
SMURF2Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
Smad2Rattransforming growth factor-beta Smad dependent signaling pathway   ISOSMAD2 (Homo sapiens) RGD 
Smad2Mousetransforming growth factor-beta Smad dependent signaling pathway   ISOSMAD2 (Homo sapiens) RGD 
Smad2Mousetransforming growth factor-beta Smad dependent signaling pathway   ISOSMAD3 (Homo sapiens) RGD 
Smad3Rattransforming growth factor-beta Smad dependent signaling pathway   ISOSMAD3 (Homo sapiens) RGD 
Smad4Rattransforming growth factor-beta Smad dependent signaling pathway   ISOSMAD4 (Homo sapiens) RGD 
Smad4Mousetransforming growth factor-beta Smad dependent signaling pathway   ISOSMAD4 (Homo sapiens) RGD 
Smad7Mousetransforming growth factor-beta Smad dependent signaling pathway   ISOSMAD7 (Homo sapiens) RGD 
Smad7Rattransforming growth factor-beta Smad dependent signaling pathway   ISOSMAD7 (Homo sapiens) RGD 
Smurf1Mousetransforming growth factor-beta Smad dependent signaling pathway   ISOSMURF1 (Homo sapiens) RGD 
Smurf1Rattransforming growth factor-beta Smad dependent signaling pathway   ISOSMURF1 (Homo sapiens) RGD 
Smurf2Rattransforming growth factor-beta Smad dependent signaling pathway   ISOSMURF2 (Homo sapiens) RGD 
Smurf2Mousetransforming growth factor-beta Smad dependent signaling pathway   ISOSMURF2 (Homo sapiens) RGD 
TGFB3Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
TGFBR1Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
TGFBR2Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
TGFBR3Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
Tgfb3Rattransforming growth factor-beta Smad dependent signaling pathway   ISOTGFB3 (Homo sapiens) RGD 
Tgfb3Mousetransforming growth factor-beta Smad dependent signaling pathway   ISOTGFB3 (Homo sapiens) RGD 
Tgfbr1Rattransforming growth factor-beta Smad dependent signaling pathway   ISOTGFBR1 (Homo sapiens) RGD 
Tgfbr1Mousetransforming growth factor-beta Smad dependent signaling pathway   ISOTGFBR1 (Homo sapiens) RGD 
Tgfbr3Rattransforming growth factor-beta Smad dependent signaling pathway   ISOTGFBR3 (Homo sapiens) RGD 
Tgfbr3Mousetransforming growth factor-beta Smad dependent signaling pathway   ISOTGFBR3 (Homo sapiens) RGD 
ZFYVE9Humantransforming growth factor-beta Smad dependent signaling pathway   TAS  RGD 
Zfyve9Rattransforming growth factor-beta Smad dependent signaling pathway   ISOZFYVE9 (Homo sapiens) RGD 
Zfyve9Mousetransforming growth factor-beta Smad dependent signaling pathway   ISOZFYVE9 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
A2m  (alpha-2-macroglobulin)
Dcn  (decorin)
Fkbp1a  (FKBP prolyl isomerase 1A)
Smad2  (SMAD family member 2)
Smad3  (SMAD family member 3)
Smad4  (SMAD family member 4)
Smad7  (SMAD family member 7)
Smurf1  (SMAD specific E3 ubiquitin protein ligase 1)
Smurf2  (SMAD specific E3 ubiquitin protein ligase 2)
Tgfb3  (transforming growth factor, beta 3)
Tgfbr1  (transforming growth factor, beta receptor 1)
Tgfbr3  (transforming growth factor beta receptor 3)
Zfyve9  (zinc finger FYVE-type containing 9)

Genes (Mus musculus)
A2m  (alpha-2-macroglobulin)
Dcn  (decorin)
Fkbp1a  (FK506 binding protein 1a)
Smad2  (SMAD family member 2)
Smad4  (SMAD family member 4)
Smad7  (SMAD family member 7)
Smurf1  (SMAD specific E3 ubiquitin protein ligase 1)
Smurf2  (SMAD specific E3 ubiquitin protein ligase 2)
Tgfb3  (transforming growth factor, beta 3)
Tgfbr1  (transforming growth factor, beta receptor I)
Tgfbr3  (transforming growth factor, beta receptor III)
Zfyve9  (zinc finger, FYVE domain containing 9)

Genes (Homo sapiens)
A2M  (alpha-2-macroglobulin)
DCN  (decorin)
FKBP1A  (FKBP prolyl isomerase 1A)
SMAD2  (SMAD family member 2)
SMAD3  (SMAD family member 3)
SMAD4  (SMAD family member 4)
SMAD7  (SMAD family member 7)
SMURF1  (SMAD specific E3 ubiquitin protein ligase 1)
SMURF2  (SMAD specific E3 ubiquitin protein ligase 2)
TGFB3  (transforming growth factor beta 3)
TGFBR1  (transforming growth factor beta receptor 1)
TGFBR2  (transforming growth factor beta receptor 2)
TGFBR3  (transforming growth factor beta receptor 3)
ZFYVE9  (zinc finger FYVE-type containing 9)


Additional Information