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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad3
Name: SMAD family member 3
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad3decreases phosphorylationISOSMAD3 (Homo sapiens)6480464CTDAcetylcysteine results in decreased phosphorylation of SMAD3 proteinPMID:34687772
Smad3multiple interactionsISOSMAD3 (Homo sapiens)6480464CTD[Acetylcysteine co-treated with Cadmium Chloride co-treated with sodium arsenite] results in decreased expression of SMAD3 mRNA; [Acetylcysteine co-treated with Cadmium] results in decreased expression of SMAD3 mRNA; [Acetylcysteine co-treated with Water Pollutants, Chemical] results in decreased expression of SMAD3 mRNA; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of SMAD3 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]PMID:21131394 PMID:29408318 PMID:30317545 PMID:34687772
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