RGD Reference Report - Negative immune factors might predominate local tumor immune status and promote carcinogenesis in cervical carcinoma. - Rat Genome Database

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Negative immune factors might predominate local tumor immune status and promote carcinogenesis in cervical carcinoma.

Authors: Zhao, Minyi  Li, Yang  Wei, Xing  Zhang, Qian  Jia, Hongran  Quan, Shimin  Cao, Di  Wang, Li  Yang, Ting  Zhao, Juan  Pei, Meili  Tian, Sijuan  Yu, Yang  Guo, Yanping  Yang, Xiaofeng 
Citation: Zhao M, etal., Virol J. 2017 Jan 13;14(1):5. doi: 10.1186/s12985-016-0670-8.
RGD ID: 38455996
Pubmed: PMID:28086903   (View Abstract at PubMed)
PMCID: PMC5237320   (View Article at PubMed Central)
DOI: DOI:10.1186/s12985-016-0670-8   (Journal Full-text)


BACKGROUND: The disequilibrium of local immune microenvironment is an essential element during tumorigenesis.
METHOD: By conducting real-time polymerase chain reaction, we identified the mRNA level of immune factors, FoxP3 (forkhead box protein P3), CCL22/CCR4 (chemokine (C-C motif) ligand 22/CC chemokine receptor 4), OX40L/OX40 (tumor necrosis factor superfamily member 4/tumor necrosis factor receptor superfamily member 4) and Smad3 (SMAD family member 3) in neoplastic foci and its periphery tissues from 30 cases of squamous cervical carcinoma and 20 cases of normal cervix.
RESULT: The FoxP3, CCL22 and CCR4 mRNA level in local immune microenvironment of normal cervix was lower than that in cervical cancer. While OX40L, OX40 and Smad3 mRNA level profile in normal cervix was higher than that in cervical cancer. Beyond individual effect, the pairwise positive correlations were demonstrated among the mRNA level of FoxP3, CCL22 and CCR4. The mRNA level of OX40 negatively correlated with CCL22, but positively correlated with Smad3. Moreover, the mRNA level of FoxP3 and CCL22 was increased while Smad3 was decreased in cervical tissue with HPV (human papilloma virus) infection.
CONCLUSION: Our data yields insight into the roles of these immune factors in cervical carcinogenesis. It may therefore be that, in microenvironment of cervical squamous cell carcinoma, along with the context of HPV infection, negative immune regulators FoxP3, CCL22 and CCR4 might overwhelm positive immune factors OX40L, OX40 and Smad3, giving rise to an immunosuppressive status and promote the progression of cervical carcinogenesis.
TRIAL REGISTRATION: Not applicable.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  

Objects Annotated

Genes (Rattus norvegicus)
Ccl22  (C-C motif chemokine ligand 22)
Ccr4  (C-C motif chemokine receptor 4)
Foxp3  (forkhead box P3)
Smad3  (SMAD family member 3)
Tnfrsf4  (TNF receptor superfamily member 4)
Tnfsf4  (TNF superfamily member 4)

Genes (Mus musculus)
Ccl22  (C-C motif chemokine ligand 22)
Ccr4  (C-C motif chemokine receptor 4)
Foxp3  (forkhead box P3)
Smad3  (SMAD family member 3)
Tnfrsf4  (tumor necrosis factor receptor superfamily, member 4)
Tnfsf4  (tumor necrosis factor (ligand) superfamily, member 4)

Genes (Homo sapiens)
CCL22  (C-C motif chemokine ligand 22)
CCR4  (C-C motif chemokine receptor 4)
FOXP3  (forkhead box P3)
SMAD3  (SMAD family member 3)
TNFRSF4  (TNF receptor superfamily member 4)
TNFSF4  (TNF superfamily member 4)


Additional Information