Smad3 (SMAD family member 3) - Rat Genome Database

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Gene: Smad3 (SMAD family member 3) Chinchilla lanigera
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Symbol: Smad3
Name: SMAD family member 3
RGD ID: 8810186
Description: ENCODES a protein that exhibits beta-catenin binding (ortholog); bHLH transcription factor binding (ortholog); chromatin binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (ortholog); activin receptor signaling pathway (ortholog); PARTICIPATES IN activin signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; ASSOCIATED WITH alcoholic liver cirrhosis (ortholog); Aneurysm (ortholog); aortic aneurysm (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: mothers against decapentaplegic homolog 3
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554508,747,651 - 8,842,136 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554508,747,651 - 8,842,003 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
activin receptor signaling pathway  (ISO)
adrenal gland development  (ISO)
cell-cell junction organization  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to virus  (ISO)
developmental growth  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic foregut morphogenesis  (ISO)
embryonic pattern specification  (ISO)
endoderm development  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
gastrulation  (ISO)
heart looping  (ISO)
immune response  (ISO)
immune system development  (ISO)
in utero embryonic development  (ISO)
JNK cascade  (ISO)
lens fiber cell differentiation  (ISO)
liver development  (ISO)
MAPK cascade  (ISO)
mesoderm formation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle hypertrophy in response to stress  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of lung blood pressure  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of osteoblast proliferation  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of wound healing  (ISO)
nodal signaling pathway  (ISO)
osteoblast development  (ISO)
osteoblast differentiation  (ISO)
paraxial mesoderm morphogenesis  (ISO)
pericardium development  (ISO)
positive regulation of alkaline phosphatase activity  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of chondrocyte differentiation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of extracellular matrix assembly  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of positive chemotaxis  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of transforming growth factor beta3 production  (ISO)
protein stabilization  (ISO)
regulation of binding  (ISO)
regulation of cell cycle  (ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of immune response  (ISO)
regulation of striated muscle tissue development  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulation of transforming growth factor beta2 production  (ISO)
response to hypoxia  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
skeletal system development  (ISO)
SMAD protein complex assembly  (ISO)
SMAD protein signal transduction  (ISO)
somitogenesis  (ISO)
T cell activation  (ISO)
thyroid gland development  (ISO)
transdifferentiation  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
ureteric bud development  (ISO)

Cellular Component

Molecular Function
beta-catenin binding  (ISO)
bHLH transcription factor binding  (ISO)
chromatin binding  (ISO)
chromatin DNA binding  (ISO)
cis-regulatory region sequence-specific DNA binding  (ISO)
co-SMAD binding  (ISO)
collagen binding  (ISO)
DEAD/H-box RNA helicase binding  (ISO)
DNA binding  (ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific  (ISO)
DNA-binding transcription factor activity  (ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific  (ISO)
DNA-binding transcription repressor activity  (ISO)
double-stranded DNA binding  (ISO)
enzyme binding  (ISO)
glucocorticoid receptor binding  (ISO)
identical protein binding  (ISO)
mineralocorticoid receptor binding  (ISO)
phosphatase binding  (ISO)
promoter-specific chromatin binding  (ISO)
protein binding  (ISO)
protein homodimerization activity  (ISO)
protein kinase binding  (ISO)
R-SMAD binding  (ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (ISO)
RNA polymerase II transcription regulatory region sequence-specific DNA binding  (ISO)
RNA polymerase II-specific DNA-binding transcription factor binding  (ISO)
sequence-specific DNA binding  (ISO)
SMAD binding  (ISO)
sterol response element binding  (ISO)
transcription cis-regulatory region binding  (ISO)
transcription coactivator binding  (ISO)
transcription factor binding  (ISO)
transforming growth factor beta receptor binding  (ISO)
ubiquitin binding  (ISO)
ubiquitin protein ligase binding  (ISO)
zinc ion binding  (ISO)

References


Genomics

Comparative Map Data
Smad3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554508,747,651 - 8,842,136 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554508,747,651 - 8,842,003 (-)NCBIChiLan1.0ChiLan1.0
SMAD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1567,063,763 - 67,195,173 (+)EnsemblGRCh38hg38GRCh38
GRCh381567,065,602 - 67,195,195 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371567,357,940 - 67,487,507 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361565,145,249 - 65,274,587 (+)NCBINCBI36hg18NCBI36
Build 341565,145,248 - 65,274,586NCBI
Celera1544,246,635 - 44,375,039 (+)NCBI
Cytogenetic Map15q22.33NCBI
HuRef1544,193,465 - 44,321,904 (+)NCBIHuRef
CHM1_11567,476,260 - 67,605,488 (+)NCBICHM1_1
Smad3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39963,554,048 - 63,665,276 (-)NCBIGRCm39mm39
GRCm39 Ensembl963,554,049 - 63,665,276 (-)Ensembl
GRCm38963,646,766 - 63,757,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,646,767 - 63,757,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv37963,494,574 - 63,605,801 (-)NCBIGRCm37mm9NCBIm37
MGSCv36963,444,773 - 63,556,000 (-)NCBImm8
Celera960,869,117 - 60,980,879 (-)NCBICelera
Cytogenetic Map9CNCBI
Smad3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2864,126,829 - 64,236,960 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl864,110,039 - 64,236,960 (-)Ensembl
Rnor_6.0868,569,530 - 68,678,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,569,530 - 68,678,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0868,290,927 - 68,397,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,803,909 - 67,952,056 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1867,822,964 - 67,971,110 (-)NCBI
Celera863,537,497 - 63,647,062 (-)NCBICelera
Cytogenetic Map8q24NCBI
SMAD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11564,284,949 - 64,414,185 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1564,284,949 - 64,414,185 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01546,013,764 - 46,143,126 (+)NCBIMhudiblu_PPA_v0panPan3
SMAD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13031,246,313 - 31,360,098 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3031,245,657 - 31,363,337 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3031,175,971 - 31,289,442 (+)NCBI
ROS_Cfam_1.03031,444,224 - 31,557,937 (+)NCBI
UMICH_Zoey_3.13031,371,657 - 31,485,227 (+)NCBI
UNSW_CanFamBas_1.03031,431,846 - 31,545,247 (+)NCBI
UU_Cfam_GSD_1.03031,673,713 - 31,787,293 (+)NCBI
Smad3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640109,232,767 - 109,341,735 (+)NCBI
SpeTri2.0NW_00493647127,080,662 - 27,185,861 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1164,998,083 - 165,124,454 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11164,998,457 - 165,124,455 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21182,902,348 - 182,926,370 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12616,319,959 - 16,446,472 (-)NCBI
ChlSab1.1 Ensembl2616,320,933 - 16,446,527 (-)Ensembl
Vero_WHO_p1.0NW_023666048125,021,354 - 125,151,320 (+)NCBI
Smad3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247815,795,652 - 5,890,047 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000007259   ⟹   ENSCLAP00000007147
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554508,747,651 - 8,842,136 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000007260   ⟹   ENSCLAP00000007148
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554508,747,651 - 8,778,900 (-)Ensembl
RefSeq Acc Id: XM_005393692   ⟹   XP_005393749
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554508,747,651 - 8,842,003 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005393694   ⟹   XP_005393751
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554508,751,751 - 8,784,169 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013518932   ⟹   XP_013374386
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554508,751,751 - 8,841,103 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005393749 (Get FASTA)   NCBI Sequence Viewer  
  XP_005393751 (Get FASTA)   NCBI Sequence Viewer  
  XP_013374386 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005393749   ⟸   XM_005393692
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005393751   ⟸   XM_005393694
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013374386   ⟸   XM_013518932
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000007148   ⟸   ENSCLAT00000007260
RefSeq Acc Id: ENSCLAP00000007147   ⟸   ENSCLAT00000007259


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005027 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000007147 ENTREZGENE
Ensembl Transcript ENSCLAT00000007259 ENTREZGENE
NCBI Gene Smad3 ENTREZGENE