GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Smad3 | decreases expression | ISO | SMAD3 (Homo sapiens) | 6480464 | CTD | Cadmium results in decreased expression of SMAD3 mRNA | PMID:33559965 | Smad3 | multiple interactions | ISO | SMAD3 (Homo sapiens) | 6480464 | CTD | [Acetylcysteine co-treated with Cadmium] results in decreased expression of SMAD3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SMAD3 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of SMAD3 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of SMAD3 protein] | PMID:29408318 PMID:34687772 PMID:35301059 | | ||||||||||||||||||||||
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