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Gene: Smad3 (SMAD family member 3) Mus musculus
Symbol: Smad3
Name: SMAD family member 3
Description: Exhibits several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and protein homodimerization activity. Involved in several processes, including animal organ development; chordate embryonic development; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to the cytoplasm; nucleus; and plasma membrane. Used to study osteoarthritis. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; limb; and nervous system. Orthologous to human SMAD3 (SMAD family member 3); PARTICIPATES IN activin signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; INTERACTS WITH (S)-nicotine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-O-oleoyl-sn-glycero-3-phosphocholine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU022421; MAD homolog 3; mad3; Madh3; mMad3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; Smad 3
Homo sapiens (human) : SMAD3 (SMAD family member 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Smad3 (SMAD family member 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smad3 (SMAD family member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SMAD3 (SMAD family member 3)
Canis lupus familiaris (dog) : SMAD3 (SMAD family member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smad3 (SMAD family member 3)
Sus scrofa (pig) : SMAD3 (SMAD family member 3)
Chlorocebus sabaeus (African green monkey) : SMAD3 (SMAD family member 3)
Heterocephalus glaber (naked mole-rat) : Smad3 (SMAD family member 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl963,646,767 - 63,757,994 (-)Ensembl
GRCm38963,646,766 - 63,757,994 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37963,494,574 - 63,605,801 (-)NCBIGRCm37mm9NCBIm37
MGSCv36963,444,773 - 63,556,000 (-)NCBImm8
Celera960,869,117 - 60,980,879 (-)NCBICelera
Cytogenetic Map9 CNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Smad3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735647
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.