Smad3 (SMAD family member 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Smad3 (SMAD family member 3) Mus musculus
Analyze
Symbol: Smad3
Name: SMAD family member 3
RGD ID: 735647
MGI Page MGI
Description: Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and promoter-specific chromatin binding activity. Involved in several processes, including JNK cascade; negative regulation of osteoblast proliferation; and positive regulation of chondrocyte differentiation. Acts upstream of or within several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; embryonic morphogenesis; and regulation of DNA-templated transcription. Located in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and limb. Used to study osteoarthritis. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Orthologous to human SMAD3 (SMAD family member 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AU022421; MAD homolog 3; mad3; Madh; Madh3; mMad3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; Smad 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39963,554,048 - 63,665,276 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl963,554,049 - 63,665,276 (-)EnsemblGRCm39 Ensembl
GRCm38963,646,766 - 63,757,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,646,767 - 63,757,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv37963,494,574 - 63,605,801 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36963,444,773 - 63,556,000 (-)NCBIMGSCv36mm8
Celera960,869,117 - 60,980,879 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-O-oleoyl-sn-glycero-3-phosphocholine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
20-HETE  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-Methoxynobiletin  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nonylphenol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
9-cis-retinoic acid  (EXP)
acetaldehyde  (ISO)
aconitic acid  (EXP,ISO)
acteoside  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-naphthoflavone  (ISO)
AM-251  (ISO)
Ammothamnine  (EXP)
amphetamine  (ISO)
andrographolide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
azithromycin  (ISO)
azoxystrobin  (ISO)
bellidifolin  (EXP,ISO)
benazepril  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
benzophenone  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
candesartan  (ISO)
Candesartan cilexetil  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbofuran  (ISO)
casticin  (ISO)
celastrol  (ISO)
ceruletide  (EXP)
CGP 52608  (ISO)
CGS-21680  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
chrysin  (EXP)
cisplatin  (EXP,ISO)
cocaine  (ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
corosolic acid  (EXP)
corticosterone  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cytochalasin D  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fenthion  (EXP)
ferulic acid  (ISO)
fipronil  (ISO)
fluoranthene  (EXP,ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
galangin  (ISO)
gallic acid  (ISO)
Ganoderic acid A  (EXP)
genistein  (ISO)
geraniol  (ISO)
glucose  (ISO)
glyphosate  (ISO)
heptachlor  (ISO)
hexachlorobenzene  (EXP,ISO)
Honokiol  (EXP,ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
irbesartan  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
isorhamnetin  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lactucin  (EXP,ISO)
lead diacetate  (ISO)
leptomycin B  (EXP)
linoleic acid  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP)
lithocholic acid  (EXP)
LY-2157299  (ISO)
lycopene  (ISO)
melphalan  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
Methylazoxymethanol acetate  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
mirtazapine  (EXP)
monocrotaline  (ISO)
Muraglitazar  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
niclosamide  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
Nonylphenol  (ISO)
ochratoxin A  (EXP,ISO)
oridonin  (ISO)
osthole  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
perfluorohexanesulfonic acid  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
Phyllanthin  (EXP)
picoxystrobin  (ISO)
picrotoxin  (ISO)
pinostrobin  (ISO)
pirinixic acid  (EXP)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salvianolic acid B  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
SCH 23390  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sorafenib  (EXP)
sphingosine 1-phosphate  (ISO)
streptozocin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tauro-beta-muricholic acid  (EXP)
taurochenodeoxycholic acid  (EXP)
taurolithocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP,ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (EXP)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vitamin D  (EXP,ISO)
vitamin E  (ISO)
zearalenone  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
ziram  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA,ISO)
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
activin receptor signaling pathway  (IBA,ISO,NAS)
adrenal gland development  (IEA,ISO)
anatomical structure morphogenesis  (IBA)
apoptotic process  (IMP)
cell differentiation  (IBA)
cell population proliferation  (IGI)
cell-cell junction organization  (ISO)
cellular response to glucose stimulus  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to virus  (IDA)
developmental growth  (IGI)
embryonic cranial skeleton morphogenesis  (IGI)
embryonic foregut morphogenesis  (IGI)
embryonic pattern specification  (IGI)
endoderm development  (IGI)
extrinsic apoptotic signaling pathway  (IEA,ISO)
gastrulation  (IGI)
heart looping  (IGI)
immune response  (IEA,ISO)
immune system development  (IGI)
in utero embryonic development  (IGI)
JNK cascade  (IMP)
lens fiber cell differentiation  (IMP)
liver development  (IGI)
MAPK cascade  (IMP)
mesoderm formation  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle hypertrophy in response to stress  (IEA,ISO)
negative regulation of cell growth  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytosolic calcium ion concentration  (IEA,ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of inflammatory response  (IMP)
negative regulation of lung blood pressure  (IEA,ISO)
negative regulation of miRNA transcription  (IEA,ISO)
negative regulation of osteoblast differentiation  (IGI)
negative regulation of osteoblast proliferation  (IMP)
negative regulation of protein catabolic process  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of wound healing  (IMP)
nodal signaling pathway  (ISO)
osteoblast development  (IGI)
osteoblast differentiation  (IMP)
paraxial mesoderm morphogenesis  (IMP)
pericardium development  (IGI)
positive regulation of alkaline phosphatase activity  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of chondrocyte differentiation  (IMP)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of epithelial to mesenchymal transition  (IEA,ISO)
positive regulation of extracellular matrix assembly  (IEA,ISO)
positive regulation of focal adhesion assembly  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of positive chemotaxis  (IEA,ISO)
positive regulation of stress fiber assembly  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IGI,IMP,ISO)
positive regulation of transforming growth factor beta3 production  (IEA,ISO)
protein stabilization  (IEA,ISO)
regulation of DNA-templated transcription  (ISO,NAS)
regulation of epithelial cell proliferation  (IMP)
regulation of immune response  (IMP)
regulation of striated muscle tissue development  (IDA)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transforming growth factor beta receptor signaling pathway  (IDA,ISO)
regulation of transforming growth factor beta2 production  (IEA,ISO)
response to angiotensin  (ISO)
response to hypoxia  (ISO)
response to transforming growth factor beta  (IGI)
signal transduction involved in regulation of gene expression  (ISO)
skeletal system development  (IGI)
SMAD protein signal transduction  (IBA,IGI,ISO)
somitogenesis  (IMP)
T cell activation  (IMP)
thyroid gland development  (IGI)
transdifferentiation  (IEA,ISO)
transforming growth factor beta receptor signaling pathway  (IBA,IDA,IMP,ISO,NAS)
ureteric bud development  (IEP)

Cellular Component

Molecular Function
beta-catenin binding  (ISO)
bHLH transcription factor binding  (ISO)
chromatin binding  (IDA)
chromatin DNA binding  (IDA)
cis-regulatory region sequence-specific DNA binding  (ISO,ISS)
co-SMAD binding  (ISO)
collagen binding  (IPI)
DEAD/H-box RNA helicase binding  (IEA,ISO)
DNA binding  (IDA,ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific  (IPI,ISO)
DNA-binding transcription factor activity  (IDA,ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific  (IBA,ISO)
DNA-binding transcription factor binding  (ISO)
DNA-binding transcription repressor activity  (IEA,ISO)
double-stranded DNA binding  (IDA)
enzyme binding  (ISO)
I-SMAD binding  (IBA)
identical protein binding  (IPI,ISO)
metal ion binding  (IEA)
nuclear glucocorticoid receptor binding  (IEA,ISO)
nuclear mineralocorticoid receptor binding  (IEA,ISO)
nuclear receptor binding  (ISO)
phosphatase binding  (IEA,ISO)
promoter-specific chromatin binding  (IDA)
protein binding  (IPI)
protein homodimerization activity  (IEA,ISO)
protein kinase binding  (IEA,ISO)
R-SMAD binding  (ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (IBA,ISO)
RNA polymerase II transcription regulatory region sequence-specific DNA binding  (IDA,ISO)
RNA polymerase II-specific DNA-binding transcription factor binding  (IPI,ISO)
sequence-specific DNA binding  (ISO)
sterol response element binding  (IEA,ISO)
transcription cis-regulatory region binding  (ISO)
transcription coactivator binding  (IEA,ISO)
transcription corepressor binding  (IEA,ISO)
transcription factor binding  (ISO)
transforming growth factor beta receptor binding  (ISO)
ubiquitin binding  (IEA,ISO)
ubiquitin protein ligase binding  (IEA,ISO)
zinc ion binding  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior definitive endoderm morphology  (IAGP)
abnormal articular cartilage morphology  (IAGP)
abnormal B cell proliferation  (IAGP)
abnormal carpal bone morphology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal CD4-positive T cell differentiation  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cell proliferation  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal circulating interleukin-6 level  (IAGP)
abnormal colon morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cumulus expansion  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endoderm development  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal heart development  (IAGP)
abnormal heart looping  (IAGP)
abnormal hepatic cord morphology  (IAGP)
abnormal hepatoblast migration  (IAGP)
abnormal hepatocyte physiology  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal joint morphology  (IAGP)
abnormal keratinocyte physiology  (IAGP)
abnormal kidney epithelium morphology  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal mesangial matrix morphology  (IAGP)
abnormal mesendoderm development  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal pericardial cavity morphology  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal posture  (IAGP)
abnormal prechordal plate morphology  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal rectum morphology  (IAGP)
abnormal renal glomerulus basement membrane thickness  (IAGP)
abnormal rib morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal somite development  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal synovial joint capsule morphology  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell proliferation  (IAGP)
abnormal talus morphology  (IAGP)
abnormal tarsal bone morphology  (IAGP)
abnormal thoracic cage morphology  (IAGP)
abnormal thymus involution  (IAGP)
abnormal vascular wound healing  (IAGP)
absent foregut  (IAGP)
calcified joint  (IAGP)
colitis  (IAGP)
colon polyps  (IAGP)
cyclopia  (IAGP)
decreased apoptosis  (IAGP)
decreased B cell apoptosis  (IAGP)
decreased blood urea nitrogen level  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral density  (IAGP)
decreased circulating alkaline phosphatase level  (IEA)
decreased circulating creatinine level  (IAGP)
decreased hepatocyte proliferation  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased kidney weight  (IAGP)
decreased litter size  (IAGP)
decreased oocyte number  (IAGP)
decreased primary ovarian follicle number  (IAGP)
decreased renal tubule apoptosis  (IAGP)
decreased secondary ovarian follicle number  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to kidney reperfusion injury  (IAGP)
decreased tertiary ovarian follicle number  (IAGP)
delayed hepatic development  (IAGP)
dilated liver sinusoidal space  (IAGP)
distended abdomen  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enhanced wound healing  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
extramedullary hematopoiesis  (IAGP)
fused somites  (IAGP)
holoprosencephaly  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased adenoma incidence  (IAGP)
increased adrenal gland tumor incidence  (IAGP)
increased atretic ovarian follicle number  (IAGP)
increased body weight  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased colon adenocarcinoma incidence  (IAGP)
increased erythrocyte cell number  (IAGP)
increased fetal size  (IAGP)
increased inflammatory response  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased metastatic potential  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased ovary tumor incidence  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased primordial ovarian follicle number  (IAGP)
increased Sertoli cell number  (IAGP)
increased susceptibility to kidney reperfusion injury  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
intestinal obstruction  (IAGP)
kyphoscoliosis  (IAGP)
kyphosis  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethargy  (IAGP)
liver hypoplasia  (IAGP)
osteoarthritis  (IAGP)
pancreas inflammation  (IAGP)
premature death  (IAGP)
premature ovarian failure  (IAGP)
preweaning lethality, complete penetrance  (IEA)
rectal prolapse  (IAGP)
reduced female fertility  (IAGP)
renal interstitial fibrosis  (IAGP)
renal tubular necrosis  (IAGP)
rostral body truncation  (IAGP)
ruffled hair  (IAGP)
small intestinal inflammation  (IAGP)
small liver  (IAGP)
small spleen  (IAGP)
small thyroid gland  (IAGP)
spleen hypoplasia  (IAGP)
stomach inflammation  (IAGP)
thymus hypoplasia  (IAGP)
tubulointerstitial nephritis  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
2. Ovarian follicle populations of the rat express TGF-beta signalling pathways. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
3. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
4. Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model. Hara S, etal., Exp Toxicol Pathol. 2014 Aug;66(5-6):225-34. doi: 10.1016/j.etp.2014.02.002. Epub 2014 Mar 26.
5. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
6. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
7. Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways. Li CY, etal., J Cardiovasc Transl Res. 2021 Aug;14(4):636-646. doi: 10.1007/s12265-020-10089-2. Epub 2021 Jan 6.
8. Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion. Liu G, etal., J Biol Chem. 2006 Oct 6;281(40):29479-90. Epub 2006 Aug 4.
9. cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Liu X, etal., Mol Pharmacol. 2006 Dec;70(6):1992-2003. Epub 2006 Sep 7.
10. Smad3 is overexpressed in advanced human prostate cancer and necessary for progressive growth of prostate cancer cells in nude mice. Lu S, etal., Clin Cancer Res. 2007 Oct 1;13(19):5692-702.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. MGD IEA MGD IEA
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. Altered expression of Smad family members in injured motor neurons of rat. Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Expression and intracellular localization of Smad proteins in human endometrial cancer. Piestrzeniewicz-Ulanska D, etal., Oncol Rep. 2003 Sep-Oct;10(5):1539-44.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal. Roth S, etal., J Med Genet. 2000 Apr;37(4):298-300.
24. FOSL2 positively regulates TGF-beta1 signalling in non-small cell lung cancer. Wang J, etal., PLoS One. 2014 Nov 6;9(11):e112150. doi: 10.1371/journal.pone.0112150. eCollection 2014.
25. Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats. Wei XH, etal., Microcirculation. 2013 Jan;20(1):17-29. doi: 10.1111/micc.12002.
26. TGF-beta signaling alterations and susceptibility to colorectal cancer. Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
27. Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway. Zhang L, etal., J Mol Histol. 2020 Feb;51(1):77-87. doi: 10.1007/s10735-020-09859-8. Epub 2020 Feb 17.
28. Negative immune factors might predominate local tumor immune status and promote carcinogenesis in cervical carcinoma. Zhao M, etal., Virol J. 2017 Jan 13;14(1):5. doi: 10.1186/s12985-016-0670-8.
Additional References at PubMed
PMID:8774881   PMID:9501027   PMID:9702197   PMID:9753318   PMID:9759503   PMID:9858566   PMID:10064594   PMID:10082515   PMID:10331191   PMID:10341708   PMID:10349636   PMID:10376010  
PMID:10511616   PMID:10559937   PMID:10647776   PMID:10681527   PMID:10708948   PMID:10708949   PMID:10708952   PMID:10708960   PMID:10823886   PMID:10862745   PMID:10922068   PMID:11042159  
PMID:11076861   PMID:11094085   PMID:11106407   PMID:11160896   PMID:11169847   PMID:11217851   PMID:11226283   PMID:11231077   PMID:11285272   PMID:11404094   PMID:11418665   PMID:11431738  
PMID:11438667   PMID:11585338   PMID:11711431   PMID:11839555   PMID:11850197   PMID:11891202   PMID:11906909   PMID:11937490   PMID:11959813   PMID:11984875   PMID:12069494   PMID:12086850  
PMID:12119348   PMID:12130649   PMID:12145309   PMID:12426318   PMID:12477932   PMID:12524424   PMID:12543979   PMID:12637528   PMID:12650946   PMID:12672795   PMID:12763048   PMID:12767930  
PMID:12782414   PMID:12814934   PMID:12815042   PMID:12815624   PMID:12839562   PMID:12839923   PMID:12842913   PMID:12845704   PMID:12880367   PMID:12943993   PMID:14502566   PMID:14517210  
PMID:14559231   PMID:14580334   PMID:14610273   PMID:14617288   PMID:14617750   PMID:14633599   PMID:14635047   PMID:14636827   PMID:14651998   PMID:14656760   PMID:14662776   PMID:14701940  
PMID:14742269   PMID:14752027   PMID:14755691   PMID:14764653   PMID:14963116   PMID:15004187   PMID:15034041   PMID:15047135   PMID:15059931   PMID:15063768   PMID:15084457   PMID:15133179  
PMID:15150273   PMID:15150278   PMID:15183723   PMID:15192076   PMID:15195967   PMID:15215176   PMID:15225210   PMID:15225218   PMID:15239668   PMID:15241418   PMID:15247277   PMID:15253712  
PMID:15254903   PMID:15260977   PMID:15265946   PMID:15273699   PMID:15277382   PMID:15282343   PMID:15292219   PMID:15295048   PMID:15356151   PMID:15464984   PMID:15470497   PMID:15489334  
PMID:15496141   PMID:15520189   PMID:15521071   PMID:15566516   PMID:15591413   PMID:15618518   PMID:15629128   PMID:15629866   PMID:15630024   PMID:15699137   PMID:15708854   PMID:15728487  
PMID:15730859   PMID:15761153   PMID:15778380   PMID:15782199   PMID:15790953   PMID:15800576   PMID:15845540   PMID:15963767   PMID:15969059   PMID:15972691   PMID:15986223   PMID:15990875  
PMID:16007227   PMID:16018191   PMID:16021625   PMID:16041381   PMID:16141072   PMID:16141073   PMID:16210645   PMID:16224064   PMID:16227596   PMID:16290023   PMID:16317010   PMID:16322555  
PMID:16354202   PMID:16354837   PMID:16355269   PMID:16382155   PMID:16403009   PMID:16423881   PMID:16424015   PMID:16435884   PMID:16477644   PMID:16484320   PMID:16581977   PMID:16601693  
PMID:16602821   PMID:16619037   PMID:16672340   PMID:16690606   PMID:16754864   PMID:16766264   PMID:16790475   PMID:16796722   PMID:16807527   PMID:16824956   PMID:16839529   PMID:16877415  
PMID:16890162   PMID:16919269   PMID:16943282   PMID:16951153   PMID:16959237   PMID:16996058   PMID:17013388   PMID:17015622   PMID:17053163   PMID:17074756   PMID:17074765   PMID:17091762  
PMID:17098824   PMID:17111301   PMID:17142805   PMID:17159989   PMID:17168649   PMID:17192514   PMID:17215516   PMID:17226765   PMID:17264540   PMID:17314307   PMID:17389684   PMID:17426249  
PMID:17429065   PMID:17429443   PMID:17460146   PMID:17467076   PMID:17485510   PMID:17513781   PMID:17585069   PMID:17592132   PMID:17595316   PMID:17606870   PMID:17624738   PMID:17628518  
PMID:17638910   PMID:17641300   PMID:17652186   PMID:17657819   PMID:17670744   PMID:17682064   PMID:17690314   PMID:17707214   PMID:17804483   PMID:17804598   PMID:17920684   PMID:17936489  
PMID:17951260   PMID:17952112   PMID:17967775   PMID:17991884   PMID:18005957   PMID:18024957   PMID:18039968   PMID:18071588   PMID:18078810   PMID:18079204   PMID:18089935   PMID:18095342  
PMID:18157133   PMID:18172167   PMID:18184649   PMID:18184786   PMID:18210139   PMID:18245174   PMID:18263591   PMID:18268325   PMID:18276785   PMID:18287559   PMID:18296617   PMID:18321991  
PMID:18329379   PMID:18335503   PMID:18353861   PMID:18353867   PMID:18395096   PMID:18434384   PMID:18453534   PMID:18462697   PMID:18474630   PMID:18497983   PMID:18502822   PMID:18506886  
PMID:18516051   PMID:18552838   PMID:18602626   PMID:18653563   PMID:18704116   PMID:18711354   PMID:18725385   PMID:18768831   PMID:18772333   PMID:18799693   PMID:18802055   PMID:18809571  
PMID:18821706   PMID:18922473   PMID:18942075   PMID:18950738   PMID:18952608   PMID:19058853   PMID:19088845   PMID:19106105   PMID:19119184   PMID:19172185   PMID:19200168   PMID:19218245  
PMID:19265200   PMID:19344627   PMID:19357234   PMID:19375497   PMID:19388084   PMID:19401440   PMID:19422482   PMID:19448624   PMID:19473993   PMID:19478656   PMID:19479035   PMID:19488034  
PMID:19498055   PMID:19505891   PMID:19517569   PMID:19535790   PMID:19553668   PMID:19580641   PMID:19587446   PMID:19597490   PMID:19609088   PMID:19646988   PMID:19671686   PMID:19679673  
PMID:19701891   PMID:19737861   PMID:19752570   PMID:19757385   PMID:19822523   PMID:19837676   PMID:19841536   PMID:19887374   PMID:19917253   PMID:19919989   PMID:19956083   PMID:19959709  
PMID:20019329   PMID:20059953   PMID:20060825   PMID:20071455   PMID:20082218   PMID:20089076   PMID:20089673   PMID:20147383   PMID:20147459   PMID:20155334   PMID:20177825   PMID:20179325  
PMID:20197623   PMID:20200042   PMID:20211142   PMID:20231525   PMID:20304828   PMID:20308569   PMID:20346939   PMID:20360068   PMID:20382892   PMID:20404343   PMID:20412781   PMID:20463050  
PMID:20488955   PMID:20508035   PMID:20522804   PMID:20548029   PMID:20581097   PMID:20595680   PMID:20599664   PMID:20607716   PMID:20682692   PMID:20709799   PMID:20798218   PMID:20842701  
PMID:20870174   PMID:20935647   PMID:21035443   PMID:21041365   PMID:21119112   PMID:21145499   PMID:21229365   PMID:21252157   PMID:21267068   PMID:21270259   PMID:21276420   PMID:21295571  
PMID:21297643   PMID:21305609   PMID:21356196   PMID:21362339   PMID:21385936   PMID:21402709   PMID:21466802   PMID:21496353   PMID:21502976   PMID:21514423   PMID:21525133   PMID:21533152  
PMID:21538804   PMID:21555266   PMID:21600798   PMID:21612856   PMID:21664424   PMID:21723505   PMID:21724602   PMID:21732483   PMID:21743024   PMID:21780244   PMID:21784902   PMID:21792478  
PMID:21798735   PMID:21852586   PMID:21856951   PMID:21868450   PMID:21873635   PMID:21937600   PMID:21939397   PMID:21990365   PMID:21995845   PMID:22036565   PMID:22045334   PMID:22048127  
PMID:22219364   PMID: