Smad3 (SMAD family member 3) - Rat Genome Database

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Gene: Smad3 (SMAD family member 3) Mus musculus
Analyze
Symbol: Smad3
Name: SMAD family member 3
RGD ID: 735647
MGI Page MGI
Description: Exhibits several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and identical protein binding activity. Involved in several processes, including animal organ development; regulation of transcription by RNA polymerase II; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; limb; and nervous system. Used to study osteoarthritis. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Orthologous to human SMAD3 (SMAD family member 3); PARTICIPATES IN activin signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; INTERACTS WITH (S)-nicotine; 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU022421; MAD homolog 3; mad3; Madh; Madh3; mMad3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; Smad 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39963,554,048 - 63,665,276 (-)NCBIGRCm39mm39
GRCm39 Ensembl963,554,049 - 63,665,276 (-)Ensembl
GRCm38963,646,766 - 63,757,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,646,767 - 63,757,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv37963,494,574 - 63,605,801 (-)NCBIGRCm37mm9NCBIm37
MGSCv36963,444,773 - 63,556,000 (-)NCBImm8
Celera960,869,117 - 60,980,879 (-)NCBICelera
Cytogenetic Map9CNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
1-O-oleoyl-sn-glycero-3-phosphocholine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-nonylphenol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
9-cis-retinoic acid  (EXP)
acetaldehyde  (ISO)
acteoside  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-naphthoflavone  (ISO)
AM-251  (ISO)
Ammothamnine  (EXP)
amphetamine  (ISO)
andrographolide  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
asbestos  (ISO)
benazepril  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
benzophenone  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
candesartan  (ISO)
Candesartan cilexetil  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbofuran  (ISO)
casticin  (ISO)
celastrol  (ISO)
CGS-21680  (ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
chrysin  (EXP)
cisplatin  (EXP,ISO)
cocaine  (ISO)
coenzyme Q10  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP,ISO)
corosolic acid  (EXP)
corticosterone  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cytochalasin D  (ISO)
D-glucose  (ISO)
Deguelin  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
diminazene diaceturate  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
ebselen  (ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
ferulic acid  (ISO)
fipronil  (ISO)
fluoranthene  (EXP,ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
galangin  (ISO)
gallic acid  (ISO)
genistein  (ISO)
geraniol  (ISO)
glucose  (ISO)
glyphosate  (ISO)
heptachlor  (ISO)
hexachlorobenzene  (EXP,ISO)
Honokiol  (EXP,ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
irbesartan  (ISO)
irinotecan  (ISO)
isorhamnetin  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
leptomycin B  (EXP)
linoleic acid  (EXP)
lipopolysaccharide  (EXP)
lithocholic acid  (EXP)
LY 364947  (EXP)
lycopene  (ISO)
melphalan  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
Methylazoxymethanol acetate  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
mirtazapine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
naringin  (ISO)
niclosamide  (EXP,ISO)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
Nonylphenol  (ISO)
ochratoxin A  (EXP,ISO)
oridonin  (ISO)
osthole  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perindopril  (ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
picrotoxin  (ISO)
pirinixic acid  (EXP)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
SCH 23390  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sorafenib  (EXP)
streptozocin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tauro-beta-muricholic acid  (EXP)
taurochenodeoxycholic acid  (EXP)
taurolithocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tungsten  (EXP)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vitamin D  (EXP,ISO)
vitamin E  (ISO)
zearalenone  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
ziram  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
activin receptor signaling pathway  (ISO)
adrenal gland development  (ISO)
anatomical structure morphogenesis  (IBA)
BMP signaling pathway  (IBA)
cell differentiation  (IBA)
cell-cell junction organization  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to virus  (IDA)
developmental growth  (IGI)
embryonic cranial skeleton morphogenesis  (IGI)
embryonic foregut morphogenesis  (IGI)
embryonic pattern specification  (IGI)
endoderm development  (IGI)
extrinsic apoptotic signaling pathway  (ISO)
gastrulation  (IGI)
heart looping  (IGI)
immune response  (ISO)
immune system development  (IGI)
in utero embryonic development  (IGI)
JNK cascade  (IMP)
lens fiber cell differentiation  (IMP)
liver development  (IGI)
MAPK cascade  (IMP)
mesoderm formation  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle hypertrophy in response to stress  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of inflammatory response  (IMP)
negative regulation of lung blood pressure  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of osteoblast differentiation  (IGI)
negative regulation of osteoblast proliferation  (IMP)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of wound healing  (IMP)
nodal signaling pathway  (ISO)
osteoblast development  (IGI)
osteoblast differentiation  (IMP)
paraxial mesoderm morphogenesis  (IMP)
pericardium development  (IGI)
positive regulation of alkaline phosphatase activity  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of chondrocyte differentiation  (IMP)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of extracellular matrix assembly  (ISO)
positive regulation of focal adhesion assembly  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of positive chemotaxis  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of transcription, DNA-templated  (IDA,ISO)
positive regulation of transforming growth factor beta3 production  (ISO)
protein stabilization  (ISO)
regulation of binding  (IDA)
regulation of cell cycle  (ISO)
regulation of epithelial cell proliferation  (IMP)
regulation of immune response  (IMP)
regulation of striated muscle tissue development  (IDA)
regulation of transcription by RNA polymerase II  (IBA,ISO)
regulation of transcription, DNA-templated  (IEA)
regulation of transforming growth factor beta receptor signaling pathway  (IDA,ISO)
regulation of transforming growth factor beta2 production  (ISO)
response to hypoxia  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
skeletal system development  (IGI)
SMAD protein complex assembly  (ISO)
SMAD protein signal transduction  (IBA,IGI)
somitogenesis  (IMP)
T cell activation  (IMP)
thyroid gland development  (IGI)
transcription by RNA polymerase II  (TAS)
transdifferentiation  (ISO)
transforming growth factor beta receptor signaling pathway  (IBA,IDA,IMP,ISO)
ureteric bud development  (IEP)

Cellular Component

Molecular Function
beta-catenin binding  (ISO)
bHLH transcription factor binding  (ISO)
chromatin binding  (IDA)
chromatin DNA binding  (IDA)
cis-regulatory region sequence-specific DNA binding  (ISO)
co-SMAD binding  (ISO)
collagen binding  (IPI)
DEAD/H-box RNA helicase binding  (ISO)
DNA binding  (ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific  (IPI,ISO)
DNA-binding transcription factor activity  (IDA,ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific  (IBA,ISO)
DNA-binding transcription repressor activity  (ISO)
double-stranded DNA binding  (IDA)
enzyme binding  (ISO)
glucocorticoid receptor binding  (ISO)
I-SMAD binding  (IBA)
identical protein binding  (IPI,ISO)
metal ion binding  (IEA)
mineralocorticoid receptor binding  (ISO)
phosphatase binding  (ISO)
promoter-specific chromatin binding  (IDA)
protein binding  (IPI,ISO)
protein homodimerization activity  (ISO)
protein kinase binding  (ISO)
R-SMAD binding  (ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (IBA,ISO)
RNA polymerase II transcription regulatory region sequence-specific DNA binding  (IDA)
RNA polymerase II-specific DNA-binding transcription factor binding  (ISO)
sequence-specific DNA binding  (ISO)
SMAD binding  (ISO)
transcription cis-regulatory region binding  (ISO)
transcription coactivator binding  (ISO)
transcription factor binding  (ISO)
transforming growth factor beta receptor binding  (ISO)
ubiquitin binding  (ISO)
ubiquitin protein ligase binding  (ISO)
zinc ion binding  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior definitive endoderm morphology  (IAGP)
abnormal articular cartilage morphology  (IAGP)
abnormal B cell proliferation  (IAGP)
abnormal carpal bone morphology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal CD4-positive T cell differentiation  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cell proliferation  (IAGP)
abnormal chondrocyte morphology  (IAGP)
abnormal circulating interleukin-6 level  (IAGP)
abnormal colon morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cumulus expansion  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endoderm development  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal heart development  (IAGP)
abnormal heart looping  (IAGP)
abnormal hepatic cord morphology  (IAGP)
abnormal hepatoblast migration  (IAGP)
abnormal hepatocyte physiology  (IAGP)
abnormal immune system morphology  (IAGP)
abnormal joint morphology  (IAGP)
abnormal keratinocyte physiology  (IAGP)
abnormal kidney epithelium morphology  (IAGP)
abnormal leukocyte physiology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal mesangial matrix morphology  (IAGP)
abnormal mesendoderm development  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal pericardial cavity morphology  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal posture  (IAGP)
abnormal prechordal plate morphology  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal rectum morphology  (IAGP)
abnormal renal glomerulus basement membrane thickness  (IAGP)
abnormal rib morphology  (IAGP)
abnormal secondary ovarian follicle morphology  (IAGP)
abnormal Sertoli cell morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal somite development  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal synovial joint capsule morphology  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell proliferation  (IAGP)
abnormal talus morphology  (IAGP)
abnormal tarsal bone morphology  (IAGP)
abnormal thoracic cage morphology  (IAGP)
abnormal thymus involution  (IAGP)
abnormal vascular wound healing  (IAGP)
absent foregut  (IAGP)
calcified joint  (IAGP)
colitis  (IAGP)
colon polyps  (IAGP)
cyclopia  (IAGP)
decreased apoptosis  (IAGP)
decreased B cell apoptosis  (IAGP)
decreased blood urea nitrogen level  (IAGP)
decreased body size  (IAGP)
decreased bone mineral density  (IAGP)
decreased circulating creatinine level  (IAGP)
decreased hepatocyte proliferation  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased kidney weight  (IAGP)
decreased litter size  (IAGP)
decreased oocyte number  (IAGP)
decreased renal tubule apoptosis  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased susceptibility to kidney reperfusion injury  (IAGP)
delayed hepatic development  (IAGP)
dilated liver sinusoidal spaces  (IAGP)
distended abdomen  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enhanced wound healing  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
extramedullary hematopoiesis  (IAGP)
fused somites  (IAGP)
holoprosencephaly  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
increased adenoma incidence  (IAGP)
increased adrenal gland tumor incidence  (IAGP)
increased body weight  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased colon adenocarcinoma incidence  (IAGP)
increased erythrocyte cell number  (IAGP)
increased fetal size  (IAGP)
increased inflammatory response  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased metastatic potential  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased ovary tumor incidence  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased susceptibility to kidney reperfusion injury  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
intestinal obstruction  (IAGP)
kyphoscoliosis  (IAGP)
kyphosis  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethargy  (IAGP)
liver hypoplasia  (IAGP)
osteoarthritis  (IAGP)
pancreas inflammation  (IAGP)
premature death  (IAGP)
premature ovarian failure  (IAGP)
rectal prolapse  (IAGP)
reduced female fertility  (IAGP)
renal interstitial fibrosis  (IAGP)
renal tubular necrosis  (IAGP)
rostral body truncation  (IAGP)
ruffled hair  (IAGP)
small intestinal inflammation  (IAGP)
small liver  (IAGP)
small spleen  (IAGP)
small thyroid gland  (IAGP)
spleen hypoplasia  (IAGP)
stomach inflammation  (IAGP)
thymus hypoplasia  (IAGP)
tubulointerstitial nephritis  (IAGP)
References

References - curated
1. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
2. Hara S, etal., Exp Toxicol Pathol. 2014 Aug;66(5-6):225-34. doi: 10.1016/j.etp.2014.02.002. Epub 2014 Mar 26.
3. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
4. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
5. Liu G, etal., J Biol Chem. 2006 Oct 6;281(40):29479-90. Epub 2006 Aug 4.
6. Liu X, etal., Mol Pharmacol. 2006 Dec;70(6):1992-2003. Epub 2006 Sep 7.
7. Lu S, etal., Clin Cancer Res. 2007 Oct 1;13(19):5692-702.
8. MGD and Homologene mouse data transfer
9. MGD data from the GO Consortium
10. MGD IEA
11. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
12. Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
13. OMIM Disease Annotation Pipeline
14. Piestrzeniewicz-Ulanska D, etal., Oncol Rep. 2003 Sep-Oct;10(5):1539-44.
15. Pipeline to import KEGG annotations from KEGG into RGD
16. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. RGD automated import pipeline
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. Roth S, etal., J Med Genet. 2000 Apr;37(4):298-300.
21. Wei XH, etal., Microcirculation. 2013 Jan;20(1):17-29. doi: 10.1111/micc.12002.
22. Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
23. Zhao M, etal., Virol J. 2017 Jan 13;14(1):5. doi: 10.1186/s12985-016-0670-8.
Additional References at PubMed
PMID:8774881   PMID:9501027   PMID:9702197   PMID:9753318   PMID:9759503   PMID:9858566   PMID:10064594   PMID:10082515   PMID:10331191   PMID:10341708   PMID:10349636   PMID:10376010  
PMID:10511616   PMID:10559937   PMID:10647776   PMID:10681527   PMID:10708948   PMID:10708949   PMID:10708952   PMID:10708960   PMID:10823886   PMID:10862745   PMID:10922068   PMID:11042159  
PMID:11076861   PMID:11094085   PMID:11106407   PMID:11160896   PMID:11169847   PMID:11217851   PMID:11226283   PMID:11231077   PMID:11285272   PMID:11404094   PMID:11418665   PMID:11431738  
PMID:11438667   PMID:11585338   PMID:11711431   PMID:11839555   PMID:11850197   PMID:11891202   PMID:11906909   PMID:11937490   PMID:11959813   PMID:11984875   PMID:12069494   PMID:12086850  
PMID:12119348   PMID:12130649   PMID:12145309   PMID:12426318   PMID:12477932   PMID:12524424   PMID:12543979   PMID:12637528   PMID:12650946   PMID:12672795   PMID:12763048   PMID:12767930  
PMID:12782414   PMID:12814934   PMID:12815042   PMID:12815624   PMID:12839562   PMID:12839923   PMID:12842913   PMID:12845704   PMID:12880367   PMID:12943993   PMID:14502566   PMID:14517210  
PMID:14559231   PMID:14580334   PMID:14610273   PMID:14617288   PMID:14617750   PMID:14633599   PMID:14635047   PMID:14636827   PMID:14651998   PMID:14656760   PMID:14662776   PMID:14701940  
PMID:14742269   PMID:14752027   PMID:14755691   PMID:14764653   PMID:14963116   PMID:15004187   PMID:15034041   PMID:15047135   PMID:15059931   PMID:15063768   PMID:15084457   PMID:15133179  
PMID:15150273   PMID:15183723   PMID:15192076   PMID:15195967   PMID:15215176   PMID:15225210   PMID:15225218   PMID:15239668   PMID:15241418   PMID:15247277   PMID:15253712   PMID:15254903  
PMID:15260977   PMID:15265946   PMID:15273699   PMID:15277382   PMID:15282343   PMID:15292219   PMID:15295048   PMID:15356151   PMID:15464984   PMID:15470497   PMID:15489334   PMID:15496141  
PMID:15520189   PMID:15521071   PMID:15566516   PMID:15591413   PMID:15618518   PMID:15629128   PMID:15629866   PMID:15630024   PMID:15699137   PMID:15708854   PMID:15728487   PMID:15730859  
PMID:15761153   PMID:15778380   PMID:15782199   PMID:15790953   PMID:15800576   PMID:15845540   PMID:15963767   PMID:15969059   PMID:15972691   PMID:15986223   PMID:15990875   PMID:16007227  
PMID:16018191   PMID:16021625   PMID:16041381   PMID:16141072   PMID:16141073   PMID:16210645   PMID:16224064   PMID:16227596   PMID:16290023   PMID:16317010   PMID:16354202   PMID:16354837  
PMID:16355269   PMID:16382155   PMID:16403009   PMID:16423881   PMID:16424015   PMID:16435884   PMID:16477644   PMID:16484320   PMID:16581977   PMID:16601693   PMID:16602821   PMID:16619037  
PMID:16672340   PMID:16690606   PMID:16754864   PMID:16766264   PMID:16790475   PMID:16796722   PMID:16807527   PMID:16824956   PMID:16839529   PMID:16877415   PMID:16890162   PMID:16919269  
PMID:16943282   PMID:16951153   PMID:16959237   PMID:16996058   PMID:17013388   PMID:17015622   PMID:17053163   PMID:17074756   PMID:17074765   PMID:17091762   PMID:17098824   PMID:17111301  
PMID:17142805   PMID:17159989   PMID:17168649   PMID:17192514   PMID:17215516   PMID:17226765   PMID:17264540   PMID:17314307   PMID:17389684   PMID:17426249   PMID:17429065   PMID:17429443  
PMID:17460146   PMID:17467076   PMID:17485510   PMID:17513781   PMID:17585069   PMID:17592132   PMID:17595316   PMID:17606870   PMID:17624738   PMID:17628518   PMID:17638910   PMID:17641300  
PMID:17652186   PMID:17657819   PMID:17670744   PMID:17682064   PMID:17690314   PMID:17707214   PMID:17804483   PMID:17804598   PMID:17920684   PMID:17936489   PMID:17951260   PMID:17952112  
PMID:17967775   PMID:17991884   PMID:18005957   PMID:18024957   PMID:18039968   PMID:18071588   PMID:18078810   PMID:18079204   PMID:18089935   PMID:18095342   PMID:18157133   PMID:18172167  
PMID:18184649   PMID:18184786   PMID:18210139   PMID:18245174   PMID:18263591   PMID:18268325   PMID:18276785   PMID:18287559   PMID:18296617   PMID:18321991   PMID:18329379   PMID:18335503  
PMID:18353861   PMID:18353867   PMID:18395096   PMID:18434384   PMID:18453534   PMID:18462697   PMID:18474630   PMID:18497983   PMID:18502822   PMID:18506886   PMID:18516051   PMID:18552838  
PMID:18602626   PMID:18653563   PMID:18704116   PMID:18711354   PMID:18725385   PMID:18768831   PMID:18772333   PMID:18799693   PMID:18802055   PMID:18809571   PMID:18821706   PMID:18922473  
PMID:18942075   PMID:18950738   PMID:18952608   PMID:19058853   PMID:19088845   PMID:19106105   PMID:19119184   PMID:19172185   PMID:19200168   PMID:19218245   PMID:19265200   PMID:19344627  
PMID:19357234   PMID:19375497   PMID:19388084   PMID:19401440   PMID:19422482   PMID:19448624   PMID:19473993   PMID:19478656   PMID:19479035   PMID:19488034   PMID:19498055   PMID:19505891  
PMID:19517569   PMID:19535790   PMID:19553668   PMID:19580641   PMID:19587446   PMID:19597490   PMID:19609088   PMID:19646988   PMID:19671686   PMID:19679673   PMID:19701891   PMID:19737861  
PMID:19752570   PMID:19757385   PMID:19822523   PMID:19837676   PMID:19841536   PMID:19887374   PMID:19917253   PMID:19919989   PMID:19956083   PMID:19959709   PMID:20019329   PMID:20059953  
PMID:20060825   PMID:20071455   PMID:20082218   PMID:20089076   PMID:20089673   PMID:20147383   PMID:20147459   PMID:20155334   PMID:20177825   PMID:20179325   PMID:20197623   PMID:20200042  
PMID:20211142   PMID:20231525   PMID:20304828   PMID:20308569   PMID:20346939   PMID:20360068   PMID:20382892   PMID:20404343   PMID:20412781   PMID:20463050   PMID:20488955   PMID:20508035  
PMID:20522804   PMID:20548029   PMID:20581097   PMID:20595680   PMID:20599664   PMID:20607716   PMID:20682692   PMID:20709799   PMID:20798218   PMID:20842701   PMID:20870174   PMID:20935647  
PMID:21035443   PMID:21041365   PMID:21119112   PMID:21145499   PMID:21229365   PMID:21252157   PMID:21267068   PMID:21270259   PMID:21276420   PMID:21295571   PMID:21297643   PMID:21305609  
PMID:21356196   PMID:21362339   PMID:21385936   PMID:21402709   PMID:21466802   PMID:21496353   PMID:21502976   PMID:21514423   PMID:21525133   PMID:21533152   PMID:21538804   PMID:21555266  
PMID:21600798   PMID:21612856   PMID:21664424   PMID:21723505   PMID:21724602   PMID:21732483   PMID:21743024   PMID:21780244   PMID:21784902   PMID:21792478   PMID:21798735   PMID:21852586  
PMID:21856951   PMID:21868450   PMID:21873635   PMID:21937600   PMID:21939397   PMID:21990365   PMID:21995845   PMID:22036565   PMID:22045334   PMID:22048127   PMID:22200784   PMID:22219364  
PMID:22237801   PMID:22291941   PMID:22294749   PMID:22331441   PMID:22378822   PMID:22382019   PMID:22398790   PMID:22411066   PMID:22418736   PMID:22427664   PMID:22437318   PMID:22438570  
PMID:22438993   PMID:22442258   PMID:22498737   PMID:22503540   PMID:22534961   PMID:22535746   PMID:22542937   PMID:22544933   PMID:22560297   PMID:22574112   PMID:22581813   PMID:22610349  
PMID:22613712   PMID:22644778   PMID:22674505   PMID:22710166   PMID:22711699   PMID:22767605   PMID:22778267   PMID:22782721   PMID:22878587   PMID:22899851   PMID:22908322   PMID:22918885  
PMID:22927430   PMID:22995554   PMID:23011393   PMID:23022526   PMID:23034213   PMID:23041440   PMID:23045614   PMID:23056222   PMID:23203799   PMID:23243069   PMID:23261458   PMID:23303459  
PMID:23326536   PMID:23328844   PMID:23375543   PMID:23390484   PMID:23439432   PMID:23497137   PMID:23537899   PMID:23546880   PMID:23584254   PMID:23585475   PMID:23603491   PMID:23620745  
PMID:23653374   PMID:23694929   PMID:23704950   PMID:23736539   PMID:23742838   PMID:23744273   PMID:23770987   PMID:23776616   PMID:23779087   PMID:23794057   PMID:23804438   PMID:23868013  
PMID:23895934   PMID:23906810   PMID:23913959   PMID:23933588   PMID:23946498   PMID:24002653   PMID:24016758   PMID:24071738   PMID:24080014   PMID:24086574   PMID:24095903   PMID:24095924  
PMID:24120438   PMID:24184030   PMID:24244446   PMID:24257627   PMID:24259511   PMID:24262754   PMID:24304543   PMID:24308975   PMID:24330661   PMID:24332550   PMID:24347165   PMID:24373743  
PMID:24391884   PMID:24412616   PMID:24438338   PMID:24449835   PMID:24478388   PMID:24485922   PMID:24498167   PMID:24519742   PMID:24569834   PMID:24594795   PMID:24606313   PMID:24614197  
PMID:24622514   PMID:24635177   PMID:24649805   PMID:24737245   PMID:24811173   PMID:24816837   PMID:24835278   PMID:24899714   PMID:24917498   PMID:24925688   PMID:24932701   PMID:24938764  
PMID:24952961   PMID:24964035   PMID:24996922   PMID:25065622   PMID:25141865   PMID:25150830   PMID:25155999   PMID:25185661   PMID:25229402   PMID:25274628   PMID:25303897   PMID:25406396  
PMID:25428587   PMID:25431176   PMID:25526531   PMID:25535343   PMID:25562158   PMID:25569105   PMID:25605784   PMID:25648888   PMID:25762570   PMID:25810340   PMID:25818617   PMID:25908723  
PMID:25942106   PMID:25985281   PMID:25985794   PMID:26053644   PMID:26120030   PMID:26151572   PMID:26194464   PMID:26219259   PMID:26272361   PMID:26284554   PMID:26321200   PMID:26322481  
PMID:26354774   PMID:26367869   PMID:26377087   PMID:26420484   PMID:26487518   PMID:26496610   PMID:26552887   PMID:26586223   PMID:26632601   PMID:26678830   PMID:26695440   PMID:26784546  
PMID:26816051   PMID:26821812   PMID:26826552   PMID:26878215   PMID:26919280   PMID:26950486   PMID:27012147   PMID:27019229   PMID:27067480   PMID:27129272   PMID:27164167   PMID:27180663  
PMID:27221338   PMID:27224286   PMID:27224923   PMID:27256716   PMID:27318131   PMID:27328306   PMID:27336669   PMID:27340942   PMID:27358050   PMID:27398409   PMID:27456065   PMID:27462873  
PMID:27466203   PMID:27470679   PMID:27503806   PMID:27506999   PMID:27513632   PMID:27588495   PMID:27614871   PMID:27653694   PMID:27688095   PMID:27720610   PMID:27741240   PMID:27748907  
PMID:27770432   PMID:27909724   PMID:27939132   PMID:27941310   PMID:27988204   PMID:27994055   PMID:28009292   PMID:28011632   PMID:28030827   PMID:28077597   PMID:28090691   PMID:28091697  
PMID:28099259   PMID:28114290   PMID:28115699   PMID:28130754   PMID:28216630   PMID:28262747   PMID:28324027   PMID:28327634   PMID:28390311   PMID:28423340   PMID:28495857   PMID:28515224  
PMID:28524854   PMID:28530637   PMID:28535372   PMID:28598443   PMID:28623179   PMID:28637791   PMID:28659340   PMID:28666967   PMID:28684544   PMID:28694203   PMID:28721450   PMID:28739802  
PMID:28747678   PMID:28759052   PMID:28763805   PMID:28770956   PMID:28781074   PMID:28825193   PMID:28849477   PMID:28852052   PMID:28877884   PMID:28891814   PMID:28912269   PMID:29073282  
PMID:29215829   PMID:29222368   PMID:29229611   PMID:29247325   PMID:29358274   PMID:29438503   PMID:29438662   PMID:29456135   PMID:29505748   PMID:29519942   PMID:29577879   PMID:29606356  
PMID:29637597   PMID:29689292   PMID:29743238   PMID:29945868   PMID:29986157   PMID:30002389   PMID:30037996   PMID:30042129   PMID:30059597   PMID:30111581   PMID:30132832   PMID:30134160  
PMID:30196744   PMID:30280598   PMID:30305733   PMID:30315770   PMID:30367168   PMID:30372567   PMID:30470612   PMID:30566624   PMID:30651315   PMID:30718289   PMID:31015579   PMID:31048367  
PMID:31092129   PMID:31119954   PMID:31141397   PMID:31150422   PMID:31311865   PMID:31334687   PMID:31400749   PMID:31424120   PMID:31496319   PMID:31623832   PMID:31649032   PMID:31677501  
PMID:31734275   PMID:31770533   PMID:31813251   PMID:31845233   PMID:31845891   PMID:31924815   PMID:31982134   PMID:32179057   PMID:32252341   PMID:32306814   PMID:32369453   PMID:32374674  
PMID:32406200   PMID:32464258   PMID:32662771   PMID:32894555   PMID:32987910   PMID:33159885   PMID:33244088   PMID:33248111   PMID:33484640   PMID:33510480   PMID:33669690  


Genomics

Comparative Map Data
Smad3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39963,554,048 - 63,665,276 (-)NCBIGRCm39mm39
GRCm39 Ensembl963,554,049 - 63,665,276 (-)Ensembl
GRCm38963,646,766 - 63,757,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,646,767 - 63,757,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv37963,494,574 - 63,605,801 (-)NCBIGRCm37mm9NCBIm37
MGSCv36963,444,773 - 63,556,000 (-)NCBImm8
Celera960,869,117 - 60,980,879 (-)NCBICelera
Cytogenetic Map9CNCBI
SMAD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1567,063,763 - 67,195,173 (+)EnsemblGRCh38hg38GRCh38
GRCh381567,065,602 - 67,195,195 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371567,357,940 - 67,487,507 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361565,145,249 - 65,274,587 (+)NCBINCBI36hg18NCBI36
Build 341565,145,248 - 65,274,586NCBI
Celera1544,246,635 - 44,375,039 (+)NCBI
Cytogenetic Map15q22.33NCBI
HuRef1544,193,465 - 44,321,904 (+)NCBIHuRef
CHM1_11567,476,260 - 67,605,488 (+)NCBICHM1_1
Smad3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2864,126,829 - 64,236,960 (-)NCBI
Rnor_6.0 Ensembl868,569,530 - 68,678,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0868,569,530 - 68,678,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0868,290,927 - 68,397,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,803,909 - 67,952,056 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1867,822,964 - 67,971,110 (-)NCBI
Celera863,537,497 - 63,647,062 (-)NCBICelera
Cytogenetic Map8q24NCBI
Smad3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554508,747,651 - 8,842,136 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554508,747,651 - 8,842,003 (-)NCBIChiLan1.0ChiLan1.0
SMAD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11564,284,949 - 64,414,185 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1564,284,949 - 64,414,185 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01546,013,764 - 46,143,126 (+)NCBIMhudiblu_PPA_v0panPan3
SMAD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13031,246,313 - 31,360,098 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3031,245,657 - 31,363,337 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3031,175,971 - 31,289,442 (+)NCBI
ROS_Cfam_1.03031,444,224 - 31,557,937 (+)NCBI
UMICH_Zoey_3.13031,371,657 - 31,485,227 (+)NCBI
UNSW_CanFamBas_1.03031,431,846 - 31,545,247 (+)NCBI
UU_Cfam_GSD_1.03031,673,713 - 31,787,293 (+)NCBI
Smad3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640109,232,767 - 109,341,735 (+)NCBI
SpeTri2.0NW_00493647127,080,662 - 27,185,861 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1164,998,083 - 165,124,454 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11164,998,457 - 165,124,455 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21182,902,348 - 182,926,370 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12616,319,959 - 16,446,472 (-)NCBI
ChlSab1.1 Ensembl2616,320,933 - 16,446,527 (-)Ensembl
Vero_WHO_p1.0NW_023666048125,021,354 - 125,151,320 (+)NCBI
Smad3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247815,795,652 - 5,890,047 (-)NCBI

Position Markers
Smad3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
AU022421  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38963,646,923 - 63,647,074UniSTSGRCm38
MGSCv37963,494,730 - 63,494,881UniSTSGRCm37
Celera960,869,273 - 60,869,424UniSTS
Cytogenetic Map9DUniSTS
Whitehead/MRC_RH9632.25UniSTS
RH138729  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38963,646,814 - 63,646,950UniSTSGRCm38
MGSCv37963,494,621 - 63,494,757UniSTSGRCm37
Celera960,869,164 - 60,869,300UniSTS
Cytogenetic Map9DUniSTS
Madh3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
cM MapUN UniSTS
Madh3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
cM MapUN UniSTS
Madh3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38963,667,786 - 63,667,916UniSTSGRCm38
MGSCv37963,515,593 - 63,515,723UniSTSGRCm37
Celera960,890,136 - 60,890,266UniSTS
Cytogenetic Map9DUniSTS
cM MapUN UniSTS
Madh3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38963,757,484 - 63,757,678UniSTSGRCm38
MGSCv37963,605,291 - 63,605,485UniSTSGRCm37
Celera960,980,370 - 60,980,564UniSTS
Cytogenetic Map9DUniSTS
Cytogenetic Map9CUniSTS
cM MapUN UniSTS
cM Map9 UniSTS
Madh3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS
cM MapUN UniSTS
cM Map9 UniSTS
Smad3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9DUniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208563Bmiq8_mbody mass index QTL 8 (mouse)92500000069000000Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93014186664141979Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93082861764828723Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93252326366523557Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93254112166541246Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93259987266600121Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93297840266978536Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93319972567199840Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93406754473531973Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93512317869123299Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93512317869123299Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93512317869123299Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93791224471912244Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93819229172192291Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93819229172192291Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93819229172192291Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93949260173492601Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94050829874700643Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94089776474897921Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94357343177573577Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94357343177573577Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94452089278520980Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4668637365923895Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94892377482923895Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94892377482923895Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94950899867244166Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
14746993Manh66_mmandible shape 66 (mouse)94990676683906766Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95024403884244166Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
13525008Hrtiq1_mheart rate time index, QTL 1 (mouse)95251479868648726Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95465267888652678Mouse
10043877Adip21_madiposity 21 (mouse)Not determined95653182690531973Mouse
1301965Vmbic5_mventral midbrain iron content 5 (mouse)Not determined95768420965923895Mouse
1301549Bbaa9_mB.burgdorferi-associated arthritis 9 (mouse)Not determined95789776471574472Mouse
4141676Neogq1_mneonatal growth QTL 1 (mouse)Not determined95789776486239920Mouse
13525007Lfhrvq1_mlow frequency time index heart rate varaiblity, QTL 1 (mouse)95887703568648726Mouse
1301172Fembrs6_mfemur breaking strength 6 (mouse)Not determined95911710593117252Mouse
1301803Stheal9_msoft tissue heal 9 (mouse)Not determined95911710593117252Mouse
5491195Mobq8_mmultigenic obesity QTL 8 (mouse)Not determined95946266493462846Mouse
1300848Skull13_mskull morphology 13 (mouse)Not determined95946266493462846Mouse
1301456Adip5_madiposity 5 (mouse)Not determined95946266493462846Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1301611Lrnx3_mlearning contextual 3 (mouse)Not determined96224248596242599Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir23bmmu-miR-23b-5pMirecordsexternal_infoNANA19582816
Mir34bmmu-miR-34b-5pOncomiRDBexternal_infoNANA23305226
Mir24-2mmu-miR-24-3pMirtarbaseexternal_infoIn situ hybridization//Luciferase reporter assay//Functional MTI19582816
Mir24-2mmu-miR-24-3pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)19536157
Mir24-1mmu-miR-24-3pMirtarbaseexternal_infoIn situ hybridization//Luciferase reporter assay//Functional MTI19582816
Mir24-1mmu-miR-24-3pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)19536157
Mir27bmmu-miR-27b-3pMirtarbaseexternal_infoIn situ hybridization//Luciferase reporter assay//Functional MTI19582816
Mir27bmmu-miR-27b-5pMirecordsexternal_infoNANA19582816
Mir140mmu-miR-140-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20071455
Mir140mmu-miR-140-3pMirecordsexternal_info{unchanged}NA20071455

Predicted Target Of
Summary Value
Count of predictions:2427
Count of miRNA genes:822
Interacting mature miRNAs:1111
Transcripts:ENSMUST00000034973, ENSMUST00000133108, ENSMUST00000137065, ENSMUST00000137713, ENSMUST00000154323
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_016769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB008192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF016189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034973   ⟹   ENSMUSP00000034973
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl963,646,767 - 63,757,994 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133108   ⟹   ENSMUSP00000122217
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl963,666,148 - 63,751,077 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137065
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl963,667,813 - 63,743,265 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137713   ⟹   ENSMUSP00000121671
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl963,654,771 - 63,666,547 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154323   ⟹   ENSMUSP00000116790
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl963,654,799 - 63,711,969 (-)Ensembl
RefSeq Acc Id: NM_016769   ⟹   NP_058049
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39963,554,049 - 63,665,276 (-)NCBI
GRCm38963,646,767 - 63,757,994 (-)NCBI
MGSCv37963,494,574 - 63,605,801 (-)RGD
Celera960,869,117 - 60,980,879 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006510819   ⟹   XP_006510882
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39963,554,048 - 63,619,505 (-)NCBI
GRCm38963,646,766 - 63,712,259 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006510821   ⟹   XP_006510884
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39963,554,048 - 63,574,172 (-)NCBI
GRCm38963,646,766 - 63,666,900 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058049   ⟸   NM_016769
- UniProtKB: Q8BUN5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006510882   ⟸   XM_006510819
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006510884   ⟸   XM_006510821
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000122217   ⟸   ENSMUST00000133108
RefSeq Acc Id: ENSMUSP00000034973   ⟸   ENSMUST00000034973
RefSeq Acc Id: ENSMUSP00000116790   ⟸   ENSMUST00000154323
RefSeq Acc Id: ENSMUSP00000121671   ⟸   ENSMUST00000137713
Protein Domains
MH1   MH2

Promoters
RGD ID:6848475
Promoter ID:MM_ACW:50896
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Kidney
Transcripts:SMAD3.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36963,498,751 - 63,499,251 (-)MPROMDB
RGD ID:6845178
Promoter ID:MM_KWN:57710
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:OTTMUST00000050964
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36963,514,076 - 63,514,927 (-)MPROMDB
RGD ID:6845175
Promoter ID:MM_KWN:57711
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:OTTMUST00000050961
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36963,559,521 - 63,560,277 (-)MPROMDB
RGD ID:6845177
Promoter ID:MM_KWN:57712
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   Lung
Transcripts:OTTMUST00000050962
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36963,590,811 - 63,591,717 (-)MPROMDB
RGD ID:6844142
Promoter ID:MM_KWN:57714
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_016769,   UC009QBJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36963,605,681 - 63,606,202 (-)MPROMDB
RGD ID:8669928
Promoter ID:EPDNEW_M12994
Type:multiple initiation site
Name:Smad3_1
Description:Mus musculus SMAD family member 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38963,757,944 - 63,758,004EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1201674 AgrOrtholog
Ensembl Genes ENSMUSG00000032402 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034973 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000116790 UniProtKB/TrEMBL
  ENSMUSP00000121671 UniProtKB/TrEMBL
  ENSMUSP00000122217 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034973 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000133108 UniProtKB/TrEMBL
  ENSMUST00000137713 UniProtKB/TrEMBL
  ENSMUST00000154323 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17127 UniProtKB/Swiss-Prot
MGD MGI:1201674 ENTREZGENE
NCBI Gene 17127 ENTREZGENE
PANTHER PTHR13703 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Smad3 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DWB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2CG44_MOUSE UniProtKB/TrEMBL
  A2CG45_MOUSE UniProtKB/TrEMBL
  F7BUP2_MOUSE UniProtKB/TrEMBL
  Q05CN3_MOUSE UniProtKB/TrEMBL
  Q3V3E0_MOUSE UniProtKB/TrEMBL
  Q8BUN5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O09064 UniProtKB/Swiss-Prot
  O09144 UniProtKB/Swiss-Prot
  O14510 UniProtKB/Swiss-Prot
  O35273 UniProtKB/Swiss-Prot
  Q8BX84 UniProtKB/Swiss-Prot
  Q92940 UniProtKB/Swiss-Prot
  Q93002 UniProtKB/Swiss-Prot
  Q9GKR4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-10 Smad3  SMAD family member 3  Smad3  MAD homolog 3 (Drosophila)  Symbol and/or name change 5135510 APPROVED