RGD Reference Report - Altered expression of Smad family members in injured motor neurons of rat. - Rat Genome Database

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Altered expression of Smad family members in injured motor neurons of rat.

Authors: Okuyama, N  Kiryu-Seo, S  Kiyama, H 
Citation: Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
RGD ID: 1643227
Pubmed: PMID:17166487   (View Abstract at PubMed)
DOI: DOI:10.1016/j.brainres.2006.11.019   (Journal Full-text)

We examined changes in the expression of Smad family members, which transduce signals from TGF-beta superfamily ligands, following hypoglossal nerve injury. RT-PCR and in situ hybridization revealed that Smad1, 2, 3 and 4 mRNAs were significantly up-regulated in injured side, whereas Smad8 mRNA was down-regulated. Immunohistochemistry and Western blotting analysis confirmed the alterations of Smad1, 2 and 4 in injured neurons. These results suggest that the Smad signaling may be important for nerve regeneration.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SMAD1HumanHypoglossal Nerve Injuries  ISOSmad1 (Rattus norvegicus)mRNA:increased expression:hypoglossal nucleusRGD 
SMAD2HumanHypoglossal Nerve Injuries  ISOSmad2 (Rattus norvegicus)mRNA:increased expression:hypoglossal nucleusRGD 
SMAD3HumanHypoglossal Nerve Injuries  ISOSmad3 (Rattus norvegicus)mRNA:increased expression:hypoglossal nucleusRGD 
SMAD4HumanHypoglossal Nerve Injuries  ISOSmad4 (Rattus norvegicus)mRNA:increased expression:hypoglossal nucleusRGD 
SMAD7HumanHypoglossal Nerve Injuries  ISOSmad7 (Rattus norvegicus)mRNA:increased expression:hypoglossal nucleusRGD 
SMAD9HumanHypoglossal Nerve Injuries  ISOSmad9 (Rattus norvegicus)mRNA:decreased expression:hypoglossal nucleusRGD 
Smad1RatHypoglossal Nerve Injuries  IEP mRNA:increased expression:hypoglossal nucleusRGD 
Smad1MouseHypoglossal Nerve Injuries  ISOSmad1 (Rattus norvegicus)mRNA:increased expression:hypoglossal nucleusRGD 
Smad2RatHypoglossal Nerve Injuries  IEP mRNA:increased expression:hypoglossal nucleusRGD 
Smad2MouseHypoglossal Nerve Injuries  ISOSmad2 (Rattus norvegicus)mRNA:increased expression:hypoglossal nucleusRGD 
Smad3RatHypoglossal Nerve Injuries  IEP mRNA:increased expression:hypoglossal nucleusRGD 
Smad3MouseHypoglossal Nerve Injuries  ISOSmad3 (Rattus norvegicus)mRNA:increased expression:hypoglossal nucleusRGD 
Smad4RatHypoglossal Nerve Injuries  IEP mRNA:increased expression:hypoglossal nucleusRGD 
Smad4MouseHypoglossal Nerve Injuries  ISOSmad4 (Rattus norvegicus)mRNA:increased expression:hypoglossal nucleusRGD 
Smad7MouseHypoglossal Nerve Injuries  ISOSmad7 (Rattus norvegicus)mRNA:increased expression:hypoglossal nucleusRGD 
Smad7RatHypoglossal Nerve Injuries  IEP mRNA:increased expression:hypoglossal nucleusRGD 
Smad9RatHypoglossal Nerve Injuries  IEP mRNA:decreased expression:hypoglossal nucleusRGD 
Smad9MouseHypoglossal Nerve Injuries  ISOSmad9 (Rattus norvegicus)mRNA:decreased expression:hypoglossal nucleusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Smad1  (SMAD family member 1)
Smad2  (SMAD family member 2)
Smad3  (SMAD family member 3)
Smad4  (SMAD family member 4)
Smad7  (SMAD family member 7)
Smad9  (SMAD family member 9)

Genes (Mus musculus)
Smad1  (SMAD family member 1)
Smad2  (SMAD family member 2)
Smad3  (SMAD family member 3)
Smad4  (SMAD family member 4)
Smad7  (SMAD family member 7)
Smad9  (SMAD family member 9)

Genes (Homo sapiens)
SMAD1  (SMAD family member 1)
SMAD2  (SMAD family member 2)
SMAD3  (SMAD family member 3)
SMAD4  (SMAD family member 4)
SMAD7  (SMAD family member 7)
SMAD9  (SMAD family member 9)


Additional Information