RGD Reference Report - Altered expression of Smad family members in injured motor neurons of rat. - Rat Genome Database

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Altered expression of Smad family members in injured motor neurons of rat.

Authors: Okuyama, N  Kiryu-Seo, S  Kiyama, H 
Citation: Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
RGD ID: 1643227
Pubmed: (View Article at PubMed) PMID:17166487
DOI: Full-text: DOI:10.1016/j.brainres.2006.11.019

We examined changes in the expression of Smad family members, which transduce signals from TGF-beta superfamily ligands, following hypoglossal nerve injury. RT-PCR and in situ hybridization revealed that Smad1, 2, 3 and 4 mRNAs were significantly up-regulated in injured side, whereas Smad8 mRNA was down-regulated. Immunohistochemistry and Western blotting analysis confirmed the alterations of Smad1, 2 and 4 in injured neurons. These results suggest that the Smad signaling may be important for nerve regeneration.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Smad1  (SMAD family member 1)
Smad2  (SMAD family member 2)
Smad3  (SMAD family member 3)
Smad4  (SMAD family member 4)
Smad7  (SMAD family member 7)
Smad9  (SMAD family member 9)

Genes (Mus musculus)
Smad1  (SMAD family member 1)
Smad2  (SMAD family member 2)
Smad3  (SMAD family member 3)
Smad4  (SMAD family member 4)
Smad7  (SMAD family member 7)
Smad9  (SMAD family member 9)

Genes (Homo sapiens)
SMAD1  (SMAD family member 1)
SMAD2  (SMAD family member 2)
SMAD3  (SMAD family member 3)
SMAD4  (SMAD family member 4)
SMAD7  (SMAD family member 7)
SMAD9  (SMAD family member 9)


Additional Information