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Gene: Smad1 (SMAD family member 1) Rattus norvegicus
Symbol: Smad1
Name: SMAD family member 1
RGD ID: 3030
Description: Predicted to have several functions, including SMAD binding activity; enzyme binding activity; and nucleic acid binding activity. Involved in several processes, including MAPK cascade; negative regulation of muscle cell apoptotic process; and positive regulation of dendrite morphogenesis. Localizes to cytoplasm and nucleus. Used to study pulmonary hypertension. Biomarker of glomerulonephritis; male infertility; nephrotic syndrome; and pulmonary hypertension. Orthologous to human SMAD1 (SMAD family member 1); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; acrylamide.
Type: protein-coding
Also known as: MAD (mothers against decapentaplegic Drosophila) homolog 1; MAD (mothers against decapentaplegic, Drosophila) homolog 1; MAD homolog 1; MAD homolog 1 (Drosophila); MAD homolog1 (mothers against decapentaplegic Drosophila); MAD homolog1 (mothers against decapentaplegic, Drosophila); Madh1; mothers against decapentaplegic homolog 1; mothers against DPP homolog 1; SMAD 1; SMAD, mothers against DPP homolog 1; SMAD, mothers against DPP homolog 1 (Drosophila)
Homo sapiens (human) : SMAD1 (SMAD family member 1)  HGNC  Alliance
Mus musculus (house mouse) : Smad1 (SMAD family member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smad1 (SMAD family member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SMAD1 (SMAD family member 1)
Canis lupus familiaris (dog) : SMAD1 (SMAD family member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smad1 (SMAD family member 1)
Sus scrofa (pig) : SMAD1 (SMAD family member 1)
Chlorocebus sabaeus (African green monkey) : SMAD1 (SMAD family member 1)
Heterocephalus glaber (naked mole-rat) : Smad1 (SMAD family member 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01932,182,942 - 32,248,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1932,188,267 - 32,248,684 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01943,079,695 - 43,145,300 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41930,348,886 - 30,409,345 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11930,353,711 - 30,414,170 (+)NCBI
Celera1928,023,055 - 28,083,575 (+)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Smad1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3030
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.