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Gene: SMAD1 (SMAD family member 1) Homo sapiens
Symbol: SMAD1
Name: SMAD family member 1
Description: Exhibits several functions, including SMAD binding activity; enzyme binding activity; and nucleic acid binding activity. Involved in positive regulation of sprouting angiogenesis; positive regulation of transcription by RNA polymerase II; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to cytoplasm; nuclear inner membrane; and protein-containing complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BSP-1; BSP1; hSMAD1; JV4-1; JV41; MAD homolog 1; MAD, mothers against decapentaplegic homolog 1; Mad-related protein 1; MADH1; MADR1; mothers against decapentaplegic homolog 1; mothers against DPP homolog 1; SMAD 1; SMAD, mothers against DPP homolog 1; smad, mothers against dpp homolog 1 (drosophila); TGF-beta signaling protein 1; transforming growth factor-beta signaling protein 1; transforming growth factor-beta-signaling protein 1
Mus musculus (house mouse) : Smad1 (SMAD family member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Smad1 (SMAD family member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smad1 (SMAD family member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SMAD1 (SMAD family member 1)
Canis lupus familiaris (dog) : SMAD1 (SMAD family member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smad1 (SMAD family member 1)
Sus scrofa (pig) : SMAD1 (SMAD family member 1)
Chlorocebus sabaeus (African green monkey) : SMAD1 (SMAD family member 1)
Heterocephalus glaber (naked mole-rat) : Smad1 (SMAD family member 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl4145,481,194 - 145,559,176 (+)EnsemblGRCh38hg38GRCh38
GRCh384145,481,306 - 145,559,176 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374146,402,951 - 146,480,328 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364146,622,401 - 146,699,778 (+)NCBINCBI36hg18NCBI36
Build 344146,760,555 - 146,837,928NCBI
Celera4143,730,483 - 143,807,862 (+)NCBI
Cytogenetic Map4q31.21NCBI
HuRef4142,134,622 - 142,210,284 (+)NCBIHuRef
CHM1_14146,379,527 - 146,456,909 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SMAD1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353457
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.