Smad4 (SMAD family member 4) - Rat Genome Database

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Gene: Smad4 (SMAD family member 4) Mus musculus
Analyze
Symbol: Smad4
Name: SMAD family member 4
RGD ID: 69092
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; collagen binding activity; and identical protein binding activity. Involved in several processes, including cell surface receptor signaling pathway; heart development; and positive regulation of protein modification process. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and positive regulation of gonadotropin secretion. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; immune system; and respiratory system. Used to study juvenile polyposis syndrome and osteogenesis imperfecta. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Orthologous to human SMAD4 (SMAD family member 4); PARTICIPATES IN altered transforming growth factor-beta Smad dependent signaling pathway; Bone morphogenetic proteins signaling pathway; colorectal cancer pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW743858; D18Wsu70; D18Wsu70e; deletion target in pancreatic carcinoma 4 homolog; DPC; DPC4; expressed sequence AW743858; MAD homolog 4; Madh; Madh4; mothers against decapentaplegic homolog 4; mothers against DPP homolog 4; Smad 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391873,767,861 - 73,836,862 (-)NCBIGRCm39mm39
GRCm39 Ensembl1873,772,080 - 73,836,851 (-)Ensembl
GRCm381873,634,790 - 73,703,791 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1873,639,009 - 73,703,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv371873,798,667 - 73,863,395 (-)NCBIGRCm37mm9NCBIm37
MGSCv361873,764,382 - 73,829,110 (-)NCBImm8
Celera1874,884,056 - 74,923,073 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1849.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acro-Osteolysis  (ISO)
aortic disease  (ISO)
brachydactyly  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
cervical cancer  (ISO)
cholangiocarcinoma  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cicatrix  (ISO)
cognitive disorder  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal adenoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Craniofacial Abnormalities  (ISO)
Cronkhite-Canada syndrome  (ISO)
Deafness  (ISO)
endometrial carcinoma  (ISO)
esophageal carcinoma  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Colitis  (IMP)
Experimental Liver Cirrhosis  (ISO)
gallbladder cancer  (ISO)
Gallstones  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal system cancer  (ISO)
genetic disease  (ISO)
Growth Mental Deficiency Syndrome of Myhre  (ISO)
head and neck squamous cell carcinoma  (IMP,ISO)
hemorrhagic disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary hemorrhagic telangiectasia  (ISO)
Hereditary Hemorrhagic Telangiectasia, Type 1  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Heterotopic Ossification  (ISO)
Human Viral Hepatitis  (ISO)
Hypoglossal Nerve Injuries  (ISO)
intellectual disability  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
invasive ductal carcinoma  (ISO)
juvenile polyposis syndrome  (IEA,ISO)
juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome  (ISO)
Laryngotracheal Stenosis, Progressive, with Short Stature and Arthropathy  (ISO)
Liver Metastasis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lymphatic Metastasis  (ISO)
Lynch syndrome  (ISO)
Microphthalmia, Cataracts, and Iris Abnormalities  (IMP)
muscular disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
non-alcoholic steatohepatitis  (IMP,ISO)
Odontogenic Cysts  (IMP)
osteogenesis imperfecta  (IEA)
ovarian cancer  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO,ISS)
pancreatic ductal carcinoma  (ISO)
Parasitic Liver Diseases  (ISO)
pre-malignant neoplasm  (ISO)
Primary Pulmonary Hypertension, 1  (ISO)
prostate adenocarcinoma  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
seminoma  (ISO)
Stomach Neoplasms  (ISO)
thoracic aortic aneurysm  (ISO)
thrombocytopenia  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2,2-tetramine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-methoxyethanol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetaldehyde  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Candesartan cilexetil  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chlordecone  (EXP)
chromium atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
Deguelin  (ISO)
dexamethasone  (EXP)
dibenziodolium  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
doxazosin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
farrerol  (ISO)
fenofibrate  (ISO)
folic acid  (EXP)
galangin  (ISO)
gallic acid  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glycerol 2-phosphate  (EXP)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
icariin  (EXP)
Isoangustone A  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
leptomycin B  (EXP)
Methylazoxymethanol acetate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
monosodium L-glutamate  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
osthole  (ISO)
ouabain  (ISO)
paracetamol  (EXP,ISO)
pentacarbonyliron  (EXP)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
platycodin D  (ISO)
progesterone  (EXP)
quercetin  (EXP,ISO)
resveratrol  (EXP,ISO)
rutin  (ISO)
SB 431542  (EXP,ISO)
sodium arsenite  (ISO)
streptozocin  (EXP,ISO)
tamibarotene  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
theobromine  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
aging  (ISO)
anatomical structure morphogenesis  (IBA,IMP)
anterior/posterior pattern specification  (IMP)
atrioventricular canal development  (IGI)
atrioventricular valve formation  (IGI)
axon guidance  (IMP)
BMP signaling pathway  (IBA,IMP,ISO)
brainstem development  (IMP)
branching involved in ureteric bud morphogenesis  (IGI)
cardiac septum development  (IGI)
cell differentiation  (IBA,IMP)
cell population proliferation  (IMP)
cellular iron ion homeostasis  (IMP)
cellular response to glucose stimulus  (ISO)
developmental growth  (IMP)
embryonic digit morphogenesis  (IMP)
endocardial cell differentiation  (IMP)
endoderm development  (IMP)
endothelial cell activation  (IMP)
epithelial to mesenchymal transition involved in endocardial cushion formation  (IMP)
ERK1 and ERK2 cascade  (ISO)
female gonad development  (IGI)
female gonad morphogenesis  (IMP)
formation of anatomical boundary  (IMP)
gastrulation  (IMP)
gastrulation with mouth forming second  (IMP)
in utero embryonic development  (IMP)
interleukin-6-mediated signaling pathway  (IDA)
intracellular signal transduction  (ISO)
kidney development  (IMP)
left ventricular cardiac muscle tissue morphogenesis  (IMP)
male gonad development  (IMP)
mesendoderm development  (IMP)
mesoderm development  (IMP)
metanephric mesenchyme morphogenesis  (IMP)
negative regulation of cardiac muscle hypertrophy  (IMP)
negative regulation of cardiac myofibril assembly  (IMP)
negative regulation of cell death  (IMP)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (IGI)
negative regulation of ERK1 and ERK2 cascade  (IMP)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP)
negative regulation of transcription, DNA-templated  (ISO)
nephrogenic mesenchyme morphogenesis  (IMP)
neural crest cell differentiation  (IMP)
neuron fate commitment  (IMP)
osteoblast differentiation  (ISO)
outflow tract septum morphogenesis  (IGI)
ovarian follicle development  (IGI,IMP,ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell proliferation involved in heart valve morphogenesis  (IMP)
positive regulation of epithelial to mesenchymal transition  (IMP)
positive regulation of follicle-stimulating hormone secretion  (IGI,IMP)
positive regulation of histone H3-K4 methylation  (IMP)
positive regulation of histone H3-K9 acetylation  (IMP)
positive regulation of luteinizing hormone secretion  (IGI,IMP)
positive regulation of pathway-restricted SMAD protein phosphorylation  (IMP)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IMP)
positive regulation of SMAD protein signal transduction  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of transcription, DNA-templated  (IDA,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulation of binding  (IDA)
regulation of cell population proliferation  (IGI,IMP)
regulation of hair follicle development  (IMP)
regulation of transcription by RNA polymerase II  (IBA,IDA)
regulation of transcription, DNA-templated  (IEA)
regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulation of transforming growth factor beta2 production  (ISO)
response to hypoxia  (ISO)
response to transforming growth factor beta  (ISO)
sebaceous gland development  (IMP)
secondary palate development  (IMP)
seminiferous tubule development  (IMP)
single fertilization  (IGI)
SMAD protein complex assembly  (ISO)
SMAD protein signal transduction  (IBA,ISO)
somite rostral/caudal axis specification  (IMP)
spermatogenesis  (IMP)
tissue morphogenesis  (IMP)
transforming growth factor beta receptor signaling pathway  (IBA,IGI,IMP,ISO)
uterus development  (IGI)
ventricular septum morphogenesis  (IMP)
wound healing  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal bile duct morphology  (IAGP)
abnormal bone collagen fibril morphology  (IAGP)
abnormal cecum morphology  (IAGP)
abnormal cerebellar molecular layer  (IAGP)
abnormal compact bone lamellar structure  (IAGP)
abnormal cumulus expansion  (IAGP)
abnormal dorsal-ventral axis patterning  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal ectoderm development  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic epiblast morphology  (IAGP)
abnormal embryonic hematopoiesis  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal embryonic-extraembryonic boundary morphology  (IAGP)
abnormal enamel morphology  (IAGP)
abnormal endoderm development  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal granulosa cell morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle regression  (IAGP)
abnormal hair growth  (IAGP)
abnormal heart right ventricle morphology  (IAGP)
abnormal heart ventricle outflow tract morphology  (IAGP)
abnormal hindbrain development  (IAGP)
abnormal hypodermis morphology  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal keratinocyte physiology  (IAGP)
abnormal kidney development  (IAGP)
abnormal large intestine morphology  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal male meiosis  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteocyte morphology  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal pancreatic duct morphology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal proximal-distal axis patterning  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal rhombomere morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal secondary ovarian follicle morphology  (IAGP)
abnormal skin appearance  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal stomach glandular epithelium morphology  (IAGP)
abnormal thymus physiology  (IAGP)
abnormal tibia morphology  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal trabecula carnea morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent anterior visceral endoderm  (IAGP)
absent atrioventricular cushions  (IAGP)
absent cumulus expansion  (IAGP)
absent egg cylinders  (IAGP)
absent foregut  (IAGP)
absent hindgut  (IAGP)
absent mesoderm  (IAGP)
absent primordial germ cells  (IAGP)
alopecia  (IAGP)
anemia  (IAGP)
chronic pancreas inflammation  (IAGP)
clavicle hypoplasia  (IAGP)
colon polyps  (IAGP)
decreased body size  (IAGP)
decreased bone mineral density  (IAGP)
decreased cell proliferation  (IAGP)
decreased compact bone thickness  (IAGP)
decreased diameter of tibia  (IAGP)
decreased embryo size  (IAGP)
decreased embryonic epiblast cell proliferation  (IAGP)
decreased inner cell mass proliferation  (IAGP)
decreased kidney collecting duct number  (IAGP)
decreased litter size  (IAGP)
decreased mature ovarian follicle number  (IAGP)
decreased oocyte number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased ovulation rate  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased tumor growth/size  (IAGP)
decreased tumor incidence  (IAGP)
decreased tumor latency  (IAGP)
delayed bone ossification  (IAGP)
dilated pancreatic duct  (IAGP)
disorganized extraembryonic tissue  (IAGP)
disorganized stomach mucosa  (IAGP)
double outlet right ventricle  (IAGP)
duodenum polyps  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality between implantation and somite formation, incomplete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning, incomplete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged hair follicles  (IAGP)
enlarged liver  (IAGP)
enlarged pancreas  (IAGP)
enlarged sebaceous gland  (IAGP)
enlarged spleen  (IAGP)
epidermal cyst  (IAGP)
epithelioid cysts  (IAGP)
failure of primitive streak formation  (IAGP)
failure to gastrulate  (IAGP)
fused somites  (IAGP)
gastric polyps  (IAGP)
hair follicle degeneration  (IAGP)
hepatic steatosis  (IAGP)
hydroureter  (IAGP)
hyperkeratosis  (IAGP)
increased adenoma incidence  (IAGP)
increased carcinoma incidence  (IAGP)
increased cholangiocarcinoma incidence  (IAGP)
increased circulating progesterone level  (IAGP)
increased compact bone thickness  (IAGP)
increased duodenum adenocarcinoma incidence  (IAGP)
increased gastric adenocarcinoma incidence  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased hair follicle cell proliferation  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased intestinal adenoma incidence  (IAGP)
increased keratinocyte proliferation  (IAGP)
increased liver weight  (IAGP)
increased lung tumor incidence  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased metastatic potential  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pancreatic ductal adenocarcinoma incidence  (IAGP)
increased pancreatic intraepithelial neoplasia incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased prostate gland adenocarcinoma incidence  (IAGP)
increased Reichert's membrane thickness  (IAGP)
increased skin papilloma incidence  (IAGP)
increased skin squamous cell carcinoma incidence  (IAGP)
increased skin tumor incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased stomach tumor incidence  (IAGP)
increased trichoepithelioma incidence  (IAGP)
increased tumor incidence  (IAGP)
increased vertical activity  (IAGP)
infertility  (IAGP)
intestine polyps  (IAGP)
kidney cysts  (IAGP)
malocclusion  (IAGP)
no abnormal phenotype detected  (IAGP)
pancreas cysts  (IAGP)
pancreas fibrosis  (IAGP)
pancreatic acinar-to-ductal metaplasia  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
rib fractures  (IAGP)
rostral body truncation  (IAGP)
short tibia  (IAGP)
small ectoplacental cone  (IAGP)
small incisors  (IAGP)
small kidney  (IAGP)
small thoracic cavity  (IAGP)
small thymus  (IAGP)
stomach epithelial hyperplasia  (IAGP)
thick epidermis  (IAGP)
thick epidermis stratum basale  (IAGP)
thick hair follicle outer root sheath  (IAGP)
thick skin  (IAGP)
thin ventricle myocardium compact layer  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
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Additional References at PubMed
PMID:9166592   PMID:9288972   PMID:9328171   PMID:9393997   PMID:9420335   PMID:9506519   PMID:9520423   PMID:9529255   PMID:9702197   PMID:10030593   PMID:10341708   PMID:10349617  
PMID:10349636   PMID:10376010   PMID:10400677   PMID:10511616   PMID:10626800   PMID:10636910   PMID:10708952   PMID:10708962   PMID:10725249   PMID:10773876   PMID:10922068   PMID:11042159  
PMID:11076861   PMID:11106407   PMID:11163184   PMID:11169847   PMID:11195460   PMID:11197776   PMID:11231077   PMID:11788714   PMID:11809702   PMID:11850197   PMID:11857783   PMID:12096346  
PMID:12145309   PMID:12270938   PMID:12374795   PMID:12414519   PMID:12421925   PMID:12426318   PMID:12432092   PMID:12477932   PMID:12520002   PMID:12524424   PMID:12543979   PMID:12557227  
PMID:12584607   PMID:12588798   PMID:12672795   PMID:12753287   PMID:12782414   PMID:12842913   PMID:12857787   PMID:12861029   PMID:12896967   PMID:12943993   PMID:14502566   PMID:14551209  
PMID:14559231   PMID:14570593   PMID:14597578   PMID:14610273   PMID:14633973   PMID:14635047   PMID:14651998   PMID:14656760   PMID:14662776   PMID:14691138   PMID:14760387   PMID:14764653  
PMID:15135236   PMID:15215210   PMID:15226823   PMID:15260977   PMID:15282343   PMID:15292219   PMID:15342483   PMID:15459107   PMID:15464984   PMID:15525990   PMID:15610403   PMID:15618518  
PMID:15657445   PMID:15737733   PMID:15741177   PMID:15830383   PMID:15883213   PMID:15899814   PMID:15923624   PMID:15925496   PMID:15963972   PMID:16023633   PMID:16115198   PMID:16123376  
PMID:16141072   PMID:16141073   PMID:16151019   PMID:16170355   PMID:16195406   PMID:16201233   PMID:16204035   PMID:16288217   PMID:16288220   PMID:16330325   PMID:16477644   PMID:16513794  
PMID:16518688   PMID:16556916   PMID:16602821   PMID:16650383   PMID:16735447   PMID:16767220   PMID:16791201   PMID:16849541   PMID:16869739   PMID:16887829   PMID:16890162   PMID:17059883  
PMID:17072319   PMID:17114584   PMID:17142805   PMID:17151782   PMID:17159989   PMID:17168649   PMID:17177285   PMID:17182123   PMID:17213286   PMID:17226765   PMID:17300215   PMID:17339028  
PMID:17349581   PMID:17353364   PMID:17369830   PMID:17429065   PMID:17452626   PMID:17467076   PMID:17493607   PMID:17550966   PMID:17568773   PMID:17585069   PMID:17596282   PMID:17628518  
PMID:17638848   PMID:17698011   PMID:17724086   PMID:17804724   PMID:17823941   PMID:17869237   PMID:17916348   PMID:17964566   PMID:17997817   PMID:18024957   PMID:18045816   PMID:18069690  
PMID:18079204   PMID:18087045   PMID:18089935   PMID:18095342   PMID:18171930   PMID:18184786   PMID:18212064   PMID:18268325   PMID:18287559   PMID:18315922   PMID:18334251   PMID:18353861  
PMID:18385792   PMID:18446800   PMID:18539898   PMID:18566469   PMID:18585065   PMID:18602626   PMID:18618014   PMID:18692037   PMID:18694570   PMID:18695001   PMID:18783722   PMID:18794355  
PMID:18799693   PMID:18804071   PMID:18974875   PMID:18981480   PMID:18986983   PMID:18988856   PMID:19002110   PMID:19073883   PMID:19170762   PMID:19204324   PMID:19224984   PMID:19251704  
PMID:19361496   PMID:19366691   PMID:19369394   PMID:19385047   PMID:19401440   PMID:19451264   PMID:19521500   PMID:19556507   PMID:19578404   PMID:19580641   PMID:19582869   PMID:19597490  
PMID:19603510   PMID:19661464   PMID:19733164   PMID:19737861   PMID:19793887   PMID:19793892   PMID:19796622   PMID:19834456   PMID:19836350   PMID:19837676   PMID:19849841   PMID:19865483  
PMID:19888897   PMID:19901970   PMID:19926752   PMID:19959815   PMID:20019187   PMID:20059953   PMID:20196951   PMID:20211142   PMID:20231279   PMID:20238004   PMID:20371653   PMID:20412781  
PMID:20427661   PMID:20454682   PMID:20498064   PMID:20573697   PMID:20621052   PMID:20689554   PMID:20727852   PMID:20852387   PMID:20877696   PMID:20889504   PMID:20933217   PMID:20941375  
PMID:20969946   PMID:21089072   PMID:21145499   PMID:21194568   PMID:21267068   PMID:21273545   PMID:21289624   PMID:21300867   PMID:21330551   PMID:21368882   PMID:21376704   PMID:21397841  
PMID:21471525   PMID:21490069   PMID:21493862   PMID:21571225   PMID:21596989   PMID:21677750   PMID:21721476   PMID:21724602   PMID:21728174   PMID:21731673   PMID:21822279   PMID:21873635  
PMID:21881210   PMID:21900682   PMID:22036565   PMID:22045334   PMID:22046433   PMID:22048127   PMID:22115830   PMID:22121131   PMID:22208613   PMID:22282597   PMID:22341455   PMID:22366399  
PMID:22370000   PMID:22371886   PMID:22418736   PMID:22438570   PMID:22442258   PMID:22469842   PMID:22498737   PMID:22542937   PMID:22560297   PMID:22644379   PMID:22689943   PMID:22772757  
PMID:22888807   PMID:22932243   PMID:22945649   PMID:23034633   PMID:23103586   PMID:23201680   PMID:23221368   PMID:23406900   PMID:23426367   PMID:23459943   PMID:23497137   PMID:23592428  
PMID:23595735   PMID:23603491   PMID:23610450   PMID:23610558   PMID:23620745   PMID:23648546   PMID:23765158   PMID:23816882   PMID:23818325   PMID:23830984   PMID:23863096   PMID:23973329  
PMID:23999427   PMID:24006258   PMID:24048844   PMID:24076600   PMID:24095903   PMID:24101723   PMID:24108699   PMID:24127404   PMID:24223846   PMID:24257627   PMID:24307592   PMID:24334458  
PMID:24384683   PMID:24501173   PMID:24553180   PMID:24625091   PMID:24739304   PMID:24784840   PMID:24837432   PMID:24899714   PMID:24952961   PMID:24982181   PMID:25029242   PMID:25070948  
PMID:25127126   PMID:25190145   PMID:25236771   PMID:25243859   PMID:25274628   PMID:25322725   PMID:25428125   PMID:25502579   PMID:25523394   PMID:25547285   PMID:25559195   PMID:25577439  
PMID:25605784   PMID:25637015   PMID:25641697   PMID:25680269   PMID:25752506   PMID:25753424   PMID:25770424   PMID:25803032   PMID:25865348   PMID:25893305   PMID:26002469   PMID:26004068  
PMID:26022109   PMID:26113728   PMID:26215566   PMID:26303528   PMID:26420484   PMID:26444546   PMID:26491026   PMID:26494787   PMID:26583325   PMID:26657771   PMID:26699655   PMID:26701088  
PMID:26876150   PMID:26918315   PMID:27006499   PMID:27068110   PMID:27156386   PMID:27164167   PMID:27194944   PMID:27224923   PMID:27265621   PMID:27271228   PMID:27300434   PMID:27335065  
PMID:27398409   PMID:27494603   PMID:27585718   PMID:27599295   PMID:27606421   PMID:27650609   PMID:27686408   PMID:27708166   PMID:27731422   PMID:27750112   PMID:27855784   PMID:27880731  
PMID:27920253   PMID:27922669   PMID:27994055   PMID:28059064   PMID:28167493   PMID:28287406   PMID:28321130   PMID:28468752   PMID:28487943   PMID:28572510   PMID:28607111   PMID:28622298  
PMID:28655168   PMID:28663280   PMID:28669622   PMID:28713933   PMID:28759002   PMID:28759045   PMID:28922976   PMID:29069290   PMID:29072299   PMID:29150241   PMID:29247325   PMID:29281831  
PMID:29352019   PMID:29437830   PMID:29460088   PMID:29463648   PMID:29483830   PMID:29507213   PMID:29528141   PMID:29663368   PMID:29735531   PMID:29800110   PMID:29930104   PMID:29934328  
PMID:29958137   PMID:29976569   PMID:29986996   PMID:30109253   PMID:30183689   PMID:30188869   PMID:30352686   PMID:30444564   PMID:30530919   PMID:30548566   PMID:30550785   PMID:30571376  
PMID:30576242   PMID:30630826   PMID:30659096   PMID:30692543   PMID:30718277   PMID:30787001   PMID:30842446   PMID:30940539   PMID:30988513   PMID:31039140   PMID:31089135   PMID:31160676  
PMID:31209059   PMID:31248101   PMID:31398665   PMID:31587991   PMID:31770533   PMID:31845891   PMID:31857584   PMID:31862386   PMID:31916354   PMID:32155285   PMID:32191302   PMID:32325033  
PMID:32341026   PMID:32358507   PMID:32369449   PMID:32385075   PMID:32434004   PMID:32457763   PMID:32470079   PMID:32473314   PMID:32620760   PMID:32929850   PMID:32968282   PMID:33248111  
PMID:33329939   PMID:34381046  


Genomics

Comparative Map Data
Smad4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391873,767,861 - 73,836,862 (-)NCBIGRCm39mm39
GRCm39 Ensembl1873,772,080 - 73,836,851 (-)Ensembl
GRCm381873,634,790 - 73,703,791 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1873,639,009 - 73,703,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv371873,798,667 - 73,863,395 (-)NCBIGRCm37mm9NCBIm37
MGSCv361873,764,382 - 73,829,110 (-)NCBImm8
Celera1874,884,056 - 74,923,073 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1849.51NCBI
SMAD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1851,028,394 - 51,085,045 (+)EnsemblGRCh38hg38GRCh38
GRCh381851,030,213 - 51,085,042 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371848,556,583 - 48,611,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361846,810,611 - 46,860,145 (+)NCBINCBI36hg18NCBI36
Build 341846,810,610 - 46,860,144NCBI
Celera1845,413,367 - 45,468,195 (+)NCBI
Cytogenetic Map18q21.2NCBI
HuRef1845,411,927 - 45,466,923 (+)NCBIHuRef
CHM1_11848,551,997 - 48,606,836 (+)NCBICHM1_1
Smad4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21867,243,742 - 67,274,438 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1867,243,742 - 67,274,438 (-)Ensembl
Rnor_6.01869,626,682 - 69,657,373 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1869,627,757 - 69,671,199 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01868,773,326 - 68,802,354 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41870,432,705 - 70,461,541 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11870,504,785 - 70,534,814 (-)NCBI
Celera1865,246,042 - 65,276,480 (-)NCBICelera
Cytogenetic Map18q12.2NCBI
Smad4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540235,961,165 - 35,994,538 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540235,956,080 - 36,001,746 (+)NCBIChiLan1.0ChiLan1.0
SMAD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11847,692,311 - 47,802,530 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1847,764,568 - 47,797,359 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01844,402,112 - 44,456,779 (+)NCBIMhudiblu_PPA_v0panPan3
SMAD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,875,989 - 23,930,027 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,882,139 - 23,969,405 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha124,868,005 - 24,956,178 (-)NCBI
ROS_Cfam_1.0123,767,402 - 23,821,366 (-)NCBI
UMICH_Zoey_3.1123,833,038 - 23,921,205 (-)NCBI
UNSW_CanFamBas_1.0123,719,264 - 23,807,404 (-)NCBI
UU_Cfam_GSD_1.0123,987,158 - 24,041,139 (-)NCBI
Smad4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494437,008,523 - 37,038,961 (-)NCBI
SpeTri2.0NW_00493649712,242,869 - 12,278,012 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1100,514,791 - 100,628,029 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11100,521,843 - 100,633,501 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21110,456,997 - 110,568,659 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11829,894,157 - 29,951,445 (-)NCBI
ChlSab1.1 Ensembl1829,897,621 - 29,934,478 (-)Ensembl
Vero_WHO_p1.0NW_0236660504,018,900 - 4,079,370 (-)NCBI
Smad4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477814,570,025 - 14,629,950 (+)NCBI

Position Markers
Smad4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
UniSTS:224921  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,667,710 - 73,667,893UniSTSGRCm38
MGSCv371873,827,364 - 73,827,547UniSTSGRCm37
Celera1874,912,742 - 74,912,925UniSTS
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
PMC316400P5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,650,984 - 73,651,604UniSTSGRCm38
MGSCv371873,810,638 - 73,811,258UniSTSGRCm37
Celera1874,896,042 - 74,896,662UniSTS
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
PMC316400P4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,650,984 - 73,651,695UniSTSGRCm38
MGSCv371873,810,638 - 73,811,349UniSTSGRCm37
Celera1874,896,042 - 74,896,753UniSTS
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
PMC316400P6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,651,123 - 73,651,604UniSTSGRCm38
MGSCv371873,810,777 - 73,811,258UniSTSGRCm37
Celera1874,896,181 - 74,896,662UniSTS
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
AF010230  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,649,730 - 73,649,898UniSTSGRCm38
MGSCv371873,809,384 - 73,809,552UniSTSGRCm37
Celera1874,894,788 - 74,894,956UniSTS
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
PMC86557P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,658,594 - 73,658,875UniSTSGRCm38
MGSCv371873,818,248 - 73,818,529UniSTSGRCm37
Celera1874,903,644 - 74,903,925UniSTS
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
D18Dev1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,649,252 - 73,649,515UniSTSGRCm38
MGSCv371873,808,906 - 73,809,169UniSTSGRCm37
Celera1874,894,310 - 74,894,573UniSTS
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
D18Wsu70e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,639,070 - 73,639,319UniSTSGRCm38
MGSCv371873,798,724 - 73,798,973UniSTSGRCm37
Celera1874,884,113 - 74,884,362UniSTS
Cytogenetic Map18E2UniSTS
cM Map1847.0UniSTS
cM Map1848.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182476282478296340Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183948686184620653Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184317804877178271Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184629021680290216Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184674183280741971Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184674183280741971Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185091908584919240Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185091908584919240Mouse
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185153522985535397Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185153522985535397Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185267220586672345Mouse
4142443Pgis1_mproteoglycan induced spondylitis 1 (mouse)Not determined185315795076826598Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185484280185496018Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185630000090300000Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185630000090300000Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185730000090702639Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185742926790702639Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5745748782586603Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5785721090702639Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185904702190702639Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185904702190702639Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185904702190702639Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185982648990702639Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185984762690702639Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186000000080000000Mouse
4142239Idd21.2_minsulin dependent diabetes susceptibility 21.2 (mouse)Not determined186113937674429343Mouse
1558803W3q16_mweight 3 weeks QTL 16 (mouse)Not determined186113937681448616Mouse
1558782Orgwq9_morgan weight QTL 9 (mouse)Not determined186113937682586603Mouse
11039518Ltpr8_mLeishmania tropica response 8 (mouse)186374183276047170Mouse
1301798Hdlq31_mHDL QTL 31 (mouse)Not determined186712626490702639Mouse
10401904Sicd4_mseizure-induced cell death 4 (mouse)Not determined186967220585496018Mouse
1301368Par2_mpulmonary adenoma resistance 2 (mouse)Not determined187022926276619461Mouse
15014786Mvlq2_mmacrovesicular liver lesion QTL 2 (mouse)187155126490702639Mouse
1302183Pas7_mpulmonary adenoma susceptibility 7 (mouse)Not determined187261252384126470Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir301mmu-miR-301a-3pOncomiRDBexternal_infoNANA23393589
Mir199a-1mmu-miR-199a-5pOncomiRDBexternal_infoNANA22821565
Mir483mmu-miR-483-3pOncomiRDBexternal_infoNANA21112326
Mir421mmu-miR-421-3pOncomiRDBexternal_infoNANA21352803
Mir146mmu-miR-146a-5pOncomiRDBexternal_infoNANA22020746
Mir146mmu-miR-146a-5pOncomiRDBexternal_infoNANA20577838
Mir130ammu-miR-130a-3pOncomiRDBexternal_infoNANA23393589
Mir146bmmu-miR-146b-5pOncomiRDBexternal_infoNANA21874046

Predicted Target Of
Summary Value
Count of predictions:853
Count of miRNA genes:421
Interacting mature miRNAs:484
Transcripts:ENSMUST00000025393, ENSMUST00000114939, ENSMUST00000129326, ENSMUST00000131339, ENSMUST00000142672, ENSMUST00000147315
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001364967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001364968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_157374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011246855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB221585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC134447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY119788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY493561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY742922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU072917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU072918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU072919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU072920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U79748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000025393   ⟹   ENSMUSP00000025393
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1873,772,080 - 73,836,851 (-)Ensembl
GRCm38.p6 Ensembl1873,639,009 - 73,703,780 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114939   ⟹   ENSMUSP00000110589
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1873,773,072 - 73,811,302 (-)Ensembl
GRCm38.p6 Ensembl1873,640,001 - 73,678,231 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129326
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1873,791,850 - 73,808,189 (-)Ensembl
GRCm38.p6 Ensembl1873,658,779 - 73,675,118 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131339
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1873,773,229 - 73,775,634 (-)Ensembl
GRCm38.p6 Ensembl1873,640,158 - 73,642,563 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142672
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1873,773,294 - 73,795,846 (-)Ensembl
GRCm38.p6 Ensembl1873,640,223 - 73,662,775 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147315
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1873,773,283 - 73,782,890 (-)Ensembl
GRCm38.p6 Ensembl1873,640,212 - 73,649,819 (-)Ensembl
RefSeq Acc Id: NM_001364967   ⟹   NP_001351896
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391873,767,861 - 73,836,862 (-)NCBI
GRCm381873,634,790 - 73,703,791 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001364968   ⟹   NP_001351897
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391873,767,861 - 73,836,862 (-)NCBI
GRCm381873,634,790 - 73,703,791 (-)NCBI
Sequence:
RefSeq Acc Id: NM_008540   ⟹   NP_032566
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391873,767,861 - 73,836,862 (-)NCBI
GRCm381873,634,790 - 73,703,791 (-)NCBI
MGSCv371873,798,667 - 73,863,395 (-)RGD
Celera1874,884,056 - 74,923,073 (-)RGD
cM Map18 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_157374
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391873,767,861 - 73,836,862 (-)NCBI
GRCm381873,634,790 - 73,703,791 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006525701   ⟹   XP_006525764
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391873,769,251 - 73,836,640 (-)NCBI
GRCm381873,634,858 - 73,703,512 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011246855   ⟹   XP_011245157
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391873,769,251 - 73,836,831 (-)NCBI
GRCm381873,634,858 - 73,703,512 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032566   ⟸   NM_008540
- Peptide Label: isoform 1
- UniProtKB: P97471 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006525764   ⟸   XM_006525701
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011245157   ⟸   XM_011246855
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001351897   ⟸   NM_001364968
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001351896   ⟸   NM_001364967
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000110589   ⟸   ENSMUST00000114939
RefSeq Acc Id: ENSMUSP00000025393   ⟸   ENSMUST00000025393
Protein Domains
MH1   MH2

Promoters
RGD ID:13678136
Promoter ID:EPDNEW_M23217
Type:single initiation site
Name:Smad4_2
Description:Mus musculus SMAD family member 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23218  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381873,701,755 - 73,701,815EPDNEW
RGD ID:13678138
Promoter ID:EPDNEW_M23218
Type:initiation region
Name:Smad4_1
Description:Mus musculus SMAD family member 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23217  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381873,703,791 - 73,703,851EPDNEW
RGD ID:6829544
Promoter ID:MM_KWN:25663
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000049900
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361873,801,686 - 73,802,186 (-)MPROMDB
RGD ID:6829543
Promoter ID:MM_KWN:25666
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000049899
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361873,835,466 - 73,835,966 (-)MPROMDB
RGD ID:6828987
Promoter ID:MM_KWN:25668
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK028578_4930578L24RIK,   OTTMUST00000049897
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361873,863,301 - 73,863,801 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:894293 AgrOrtholog
Ensembl Genes ENSMUSG00000024515 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000025393 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000110589 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025393 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000114939 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17128 UniProtKB/Swiss-Prot
MGD MGI:894293 ENTREZGENE
NCBI Gene 17128 ENTREZGENE
PANTHER PTHR13703 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Smad4 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DWB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E3SRG7_MOUSE UniProtKB/TrEMBL
  E3SRG8_MOUSE UniProtKB/TrEMBL
  E3SRG9_MOUSE UniProtKB/TrEMBL
  E3SRH0_MOUSE UniProtKB/TrEMBL
  P97471 ENTREZGENE
  Q811W8_MOUSE UniProtKB/TrEMBL
  SMAD4_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q6GTP6 UniProtKB/Swiss-Prot
  Q9CW56 UniProtKB/Swiss-Prot