SMAD4 (SMAD family member 4) - Rat Genome Database

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Gene: SMAD4 (SMAD family member 4) Homo sapiens
Symbol: SMAD4
Name: SMAD family member 4
RGD ID: 1352527
HGNC Page HGNC:6770
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; SMAD binding activity; and transcription coregulator binding activity. Contributes to DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including positive regulation of transforming growth factor beta receptor signaling pathway; regulation of gene expression; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within negative regulation of canonical Wnt signaling pathway. Located in centrosome; cytosol; and nucleus. Part of SMAD protein complex; activin responsive factor complex; and chromatin. Implicated in several diseases, including female reproductive organ cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Biomarker of several diseases, including carcinoma (multiple); colorectal adenoma; female reproductive organ cancer (multiple); metabolic dysfunction-associated steatohepatitis; and prostate carcinoma in situ.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; DPC4; hSMAD4; JIP; MAD homolog 4; MAD, mothers against decapentaplegic homolog 4; MADH4; mothers against decapentaplegic homolog 4; mothers against decapentaplegic, Drosophila, homolog of, 4; mothers against DPP homolog 4; MYHRS; SMAD 4; SMAD, mothers against DPP homolog 4; smad, mothers against dpp homolog 4 (drosophila)
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381851,030,213 - 51,085,042 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1851,028,528 - 51,085,045 (+)EnsemblGRCh38hg38GRCh38
GRCh371848,556,583 - 48,611,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361846,810,611 - 46,860,145 (+)NCBINCBI36Build 36hg18NCBI36
Build 341846,810,610 - 46,860,144NCBI
Celera1845,413,367 - 45,468,195 (+)NCBICelera
Cytogenetic Map18q21.2NCBI
HuRef1845,411,927 - 45,466,923 (+)NCBIHuRef
CHM1_11848,551,997 - 48,606,836 (+)NCBICHM1_1
T2T-CHM13v2.01851,231,926 - 51,286,759 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)