SMAD4 (SMAD family member 4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: SMAD4 (SMAD family member 4) Homo sapiens
Analyze
Symbol: SMAD4
Name: SMAD family member 4
RGD ID: 1352527
HGNC Page HGNC:6770
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; SMAD binding activity; and protein homodimerization activity. Contributes to DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; regulation of gene expression; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in several cellular components, including centrosome; chromatin; and nucleus. Part of SMAD protein complex and activin responsive factor complex. Implicated in several diseases, including female reproductive organ cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Biomarker of several diseases, including carcinoma (multiple); colorectal adenoma; female reproductive organ cancer (multiple); non-alcoholic steatohepatitis; and prostate carcinoma in situ.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; DPC4; hSMAD4; JIP; MAD homolog 4; MAD, mothers against decapentaplegic homolog 4; MADH4; mothers against decapentaplegic homolog 4; mothers against decapentaplegic, Drosophila, homolog of, 4; mothers against DPP homolog 4; MYHRS; SMAD 4; SMAD, mothers against DPP homolog 4; smad, mothers against dpp homolog 4 (drosophila)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381851,030,213 - 51,085,042 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1851,028,394 - 51,085,045 (+)EnsemblGRCh38hg38GRCh38
GRCh371848,556,583 - 48,611,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361846,810,611 - 46,860,145 (+)NCBINCBI36hg18NCBI36
Build 341846,810,610 - 46,860,144NCBI
Celera1845,413,367 - 45,468,195 (+)NCBI
Cytogenetic Map18q21.2NCBI
HuRef1845,411,927 - 45,466,923 (+)NCBIHuRef
CHM1_11848,551,997 - 48,606,836 (+)NCBICHM1_1
T2T-CHM13v2.01851,231,926 - 51,286,759 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model