SMAD4 (SMAD family member 4) - Rat Genome Database

Name: SMAD4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: SMAD4 (SMAD family member 4) Homo sapiens

Analyze

Symbol:

SMAD4

Name:

SMAD family member 4

RGD ID:

1352527

HGNC Page

HGNC:6770

Description:

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; SMAD binding activity; and protein homodimerization activity. Contributes to DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; regulation of gene expression; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in several cellular components, including centrosome; chromatin; and nucleus. Part of SMAD protein complex and activin responsive factor complex. Implicated in several diseases, including female reproductive organ cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Biomarker of several diseases, including carcinoma (multiple); colorectal adenoma; female reproductive organ cancer (multiple); non-alcoholic steatohepatitis; and prostate carcinoma in situ.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; DPC4; hSMAD4; JIP; MAD homolog 4; MAD, mothers against decapentaplegic homolog 4; MADH4; mothers against decapentaplegic homolog 4; mothers against decapentaplegic, Drosophila, homolog of, 4; mothers against DPP homolog 4; MYHRS; SMAD 4; SMAD, mothers against DPP homolog 4; smad, mothers against dpp homolog 4 (drosophila)

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Smad4 (SMAD family member 4)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Smad4 (SMAD family member 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Chinchilla lanigera (long-tailed chinchilla):	Smad4 (SMAD family member 4)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	SMAD4 (SMAD family member 4)	NCBI	Ortholog
Canis lupus familiaris (dog):	SMAD4 (SMAD family member 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Smad4 (SMAD family member 4)	NCBI	Ortholog
Sus scrofa (pig):	SMAD4 (SMAD family member 4)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	SMAD4 (SMAD family member 4)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Smad4 (SMAD family member 4)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Smad4 (SMAD family member 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Smad4 (SMAD family member 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	smad4b (SMAD family member 4b)	Alliance	DIOPT (OrthoFinder\|PhylomeDB\|ZFIN)
Danio rerio (zebrafish):	smad4a (SMAD family member 4a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	Med	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sma-4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	51,030,213 - 51,085,042 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	18	51,028,394 - 51,085,045 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	48,556,583 - 48,611,412 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	46,810,611 - 46,860,145 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	18	46,810,610 - 46,860,144	NCBI
Celera	18	45,413,367 - 45,468,195 (+)	NCBI
Cytogenetic Map	18	q21.2	NCBI
HuRef	18	45,411,927 - 45,466,923 (+)	NCBI		HuRef
CHM1_1	18	48,551,997 - 48,606,836 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	51,231,926 - 51,286,759 (+)	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar