MIR146B (microRNA 146b) - Rat Genome Database
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Gene: MIR146B (microRNA 146b) Homo sapiens
Analyze
Symbol: MIR146B
Name: microRNA 146b
RGD ID: 1603775
HGNC Page HGNC
Description: Predicted to be involved in several processes, including cellular response to lipopolysaccharide; cellular response to tumor necrosis factor; and sensory perception of sound. Biomarker of type 2 diabetes mellitus.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-146b; MIRN146B; miRNA146B
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10102,436,512 - 102,436,584 (+)EnsemblGRCh38hg38GRCh38
GRCh3810102,436,512 - 102,436,584 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710104,196,269 - 104,196,341 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,186,258 - 104,186,330 (+)NCBINCBI36hg18NCBI36
Celera1097,937,172 - 97,937,244 (+)NCBI
Cytogenetic Map10q24.32NCBI
HuRef1097,829,357 - 97,829,429 (+)NCBIHuRef
CHM1_110104,479,721 - 104,479,793 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

Additional References at PubMed
PMID:15965474   PMID:16381832   PMID:16885212   PMID:17604727   PMID:18504431   PMID:19190326   PMID:19265686   PMID:19584273   PMID:20406109   PMID:20874002   PMID:21037258   PMID:21472990  
PMID:21537871   PMID:21789255   PMID:21823013   PMID:21874046   PMID:22393448   PMID:22728346   PMID:23264400   PMID:23535732   PMID:23592910   PMID:23733368   PMID:23796692   PMID:23798430  
PMID:24133439   PMID:24163379   PMID:24301304   PMID:24428800   PMID:24473196   PMID:24589738   PMID:24631480   PMID:24643689   PMID:24931464   PMID:24946010   PMID:24982425   PMID:25261470  
PMID:25456009   PMID:25524940   PMID:25544772   PMID:25547151   PMID:25572123   PMID:25617731   PMID:25753878   PMID:25760482   PMID:25771986   PMID:25819770   PMID:25824148   PMID:25960292  
PMID:26116595   PMID:26178670   PMID:26282166   PMID:26320176   PMID:26338965   PMID:26406414   PMID:26418898   PMID:26549292   PMID:26631297   PMID:26646931   PMID:26785832   PMID:27011326  
PMID:27166258   PMID:27273955   PMID:27485827   PMID:27497395   PMID:27533309   PMID:27550837   PMID:27997912   PMID:28404923   PMID:28427206   PMID:28436462   PMID:28466779   PMID:28473658  
PMID:28623542   PMID:28662100   PMID:28727754   PMID:29048680   PMID:29048684   PMID:29353884   PMID:29402794   PMID:29443743   PMID:29685895   PMID:29953617   PMID:30145833   PMID:30333561  
PMID:30362152   PMID:30409964   PMID:30452118   PMID:30454026   PMID:30503553   PMID:30504757   PMID:30643010   PMID:30734320   PMID:31099048   PMID:31122533   PMID:31156641   PMID:31223622  
PMID:31311940   PMID:31441000   PMID:31527804   PMID:31583932   PMID:31599663   PMID:31935378   PMID:32037949   PMID:32481361  


Genomics

Comparative Map Data
MIR146B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10102,436,512 - 102,436,584 (+)EnsemblGRCh38hg38GRCh38
GRCh3810102,436,512 - 102,436,584 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710104,196,269 - 104,196,341 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,186,258 - 104,186,330 (+)NCBINCBI36hg18NCBI36
Celera1097,937,172 - 97,937,244 (+)NCBI
Cytogenetic Map10q24.32NCBI
HuRef1097,829,357 - 97,829,429 (+)NCBIHuRef
CHM1_110104,479,721 - 104,479,793 (+)NCBICHM1_1
Mir146b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,331,201 - 46,331,309 (+)NCBIGRCm39mm39
GRCm381946,342,762 - 46,342,870 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,342,762 - 46,342,870 (+)EnsemblGRCm38mm10GRCm38
MGSCv371946,417,252 - 46,417,360 (+)NCBIGRCm37mm9NCBIm37
Celera1947,106,096 - 47,106,204 (+)NCBICelera
Cytogenetic Map19C3NCBI
Mir146b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01266,089,488 - 266,089,575 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,089,488 - 266,089,575 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01273,520,429 - 273,520,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41251,558,047 - 251,558,134 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1240,986,212 - 240,986,299 (+)NCBICelera
Cytogenetic Map1q54NCBI
MIR146B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2814,940,550 - 14,940,610 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12814,940,550 - 14,940,610 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
MIR146B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.114113,446,854 - 113,446,952 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214123,301,752 - 123,301,850 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
PDGFBhsa-miR-146b-3pMirtarbaseexternal_infoELISA//Immunoblot//Microarray//qRT-PCRFunctional MTI (Weak)21266476
NFKB1hsa-miR-146b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18504431
CDKN1Ahsa-miR-146b-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI20101223
MMP16hsa-miR-146b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19265686
KIThsa-miR-146b-5pMirtarbaseexternal_infoNorthern blot//qRT-PCR//Western blotFunctional MTI16365291
CARD10hsa-miR-146b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI21305051
SCUBE2hsa-miR-146b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRNon-Functional MTI21305051
TRAF6hsa-miR-146b-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Northern blFunctional MTI16885212
PTGS1hsa-miR-146b-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
EGFRhsa-miR-146b-5pTarbaseexternal_infoWesternblitPOSITIVE
SMAD4hsa-miR-146b-5pOncomiRDBexternal_infoNANA21874046
BRCA1hsa-miR-146b-5pOncomiRDBexternal_infoNANA21472990
EGFRhsa-miR-146b-5pOncomiRDBexternal_infoNANA20874002
MMP16hsa-miR-146b-5pOncomiRDBexternal_infoNANA19265686
ROCK1hsa-miR-146b-5pOncomiRDBexternal_infoNANA18174313

Predicted Targets
Summary Value
Count of predictions:50622
Count of gene targets:18365
Count of transcripts:42967
Interacting mature miRNAs:hsa-miR-146b-3p, hsa-miR-146b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 4 9 4
Low 37 8 50 30 112 33 34 24 31 35 74 68 2 3 8
Below cutoff 21 10 1 16 3 20 15 26 6 19 33 1 3 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000365699
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl10102,436,512 - 102,436,584 (+)Ensembl
RefSeq Acc Id: NR_030169
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810102,436,512 - 102,436,584 (+)NCBI
GRCh3710104,196,269 - 104,196,341 (+)RGD
Celera1097,937,172 - 97,937,244 (+)RGD
HuRef1097,829,357 - 97,829,429 (+)ENTREZGENE
CHM1_110104,479,721 - 104,479,793 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q23.33-25.3(chr10:95112607-116776637)x3 copy number gain See cases [RCV000050747] Chr10:95112607..116776637 [GRCh38]
Chr10:96872364..118383651 [GRCh37]
Chr10:96862354..118526138 [NCBI36]
Chr10:10q23.33-25.3
pathogenic
GRCh38/hg38 10q24.32-24.33(chr10:102243341-103929730)x1 copy number loss See cases [RCV000052568] Chr10:102243341..103929730 [GRCh38]
Chr10:104003098..105689488 [GRCh37]
Chr10:103993088..105679478 [NCBI36]
Chr10:10q24.32-24.33
pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3
pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100194215-132432797)x3 copy number gain See cases [RCV000053564] Chr10:100194215..132432797 [GRCh38]
Chr10:101953972..134246301 [GRCh37]
Chr10:101943962..134096291 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100600492-133622588)x3 copy number gain See cases [RCV000137747] Chr10:100600492..133622588 [GRCh38]
Chr10:102360249..135436092 [GRCh37]
Chr10:102350239..135286082 [NCBI36]
Chr10:10q24.31-26.3
pathogenic
GRCh37/hg19 10q24.32-26.3(chr10:103288313-135512075)x3 copy number gain See cases [RCV000240457] Chr10:103288313..135512075 [GRCh37]
Chr10:10q24.32-26.3
pathogenic
GRCh37/hg19 10q24.2-26.3(chr10:100780957-135427143)x3 copy number gain See cases [RCV000446733] Chr10:100780957..135427143 [GRCh37]
Chr10:10q24.2-26.3
pathogenic
GRCh37/hg19 10q23.1-25.1(chr10:85557432-105804295)x1 copy number loss PARP Inhibitor response [RCV000431909] Chr10:85557432..105804295 [GRCh37]
Chr10:10q23.1-25.1
pathogenic|drug response
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q24.32-25.3(chr10:104030479-115410590)x1 copy number loss See cases [RCV000448581] Chr10:104030479..115410590 [GRCh37]
Chr10:10q24.32-25.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss PARP Inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3
drug response
GRCh37/hg19 10q23.33-26.3(chr10:94346520-135427143)x3 copy number gain not provided [RCV000683291] Chr10:94346520..135427143 [GRCh37]
Chr10:10q23.33-26.3
pathogenic
GRCh37/hg19 10q24.32-24.33(chr10:103891057-105339973)x1 copy number loss not provided [RCV000683260] Chr10:103891057..105339973 [GRCh37]
Chr10:10q24.32-24.33
likely pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:32079 AgrOrtholog
COSMIC MIR146B COSMIC
Ensembl Genes ENSG00000202569 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000365699 ENTREZGENE
GTEx ENSG00000202569 GTEx
HGNC ID HGNC:32079 ENTREZGENE
Human Proteome Map MIR146B Human Proteome Map
miRBase MI0003129 ENTREZGENE
NCBI Gene 574447 ENTREZGENE
OMIM 610567 OMIM
PharmGKB PA164722498 PharmGKB
RNAcentral URS000075C2A0 RNACentral
  URS000075DF95 RNACentral
  URS0000D52743 RNACentral