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Gene: Flna (filamin A) Rattus norvegicus
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Symbol: Flna
Name: filamin A
Description: Exhibits SMAD binding activity and mu-type opioid receptor binding activity. Involved in several processes, including establishment of Sertoli cell barrier; mRNA transcription by RNA polymerase II; and nervous system development. Localizes to several cellular components, including the cytoskeleton; dendrite; and glutamatergic synapse. Used to study periventricular nodular heterotopia. Human ortholog(s) of this gene implicated in FG syndrome; craniosynostosis; mitral valve prolapse; osteochondrodysplasia; and periventricular nodular heterotopia. Orthologous to human FLNA (filamin A); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; integrin mediated signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 4,4'-diaminodiphenylmethane; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: actin binding protein 280; Endothelial actin-binding protein 280); filamin A, alpha; filamin, alpha; filamin-A; LOC293860; RGD1560614; similar to Filamin A (Alpha-filamin) (Filamin 1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin); similar to Filamin A (Alpha-filamin, Endothelial actin-binding protein 280)
Orthologs:
Homo sapiens (human) : FLNA (filamin A)  HGNC  Alliance
Mus musculus (house mouse) : Flna (filamin, alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flna (filamin A)
Pan paniscus (bonobo/pygmy chimpanzee) : FLNA (filamin A)
Canis lupus familiaris (dog) : FLNA (filamin A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flna (filamin A)
Sus scrofa (pig) : FLNA (filamin A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X156,460,785 - 156,487,245 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,463,953 - 156,487,245 (+)Ensembl
Rnor_5.01152,200,936 - 152,227,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,362,334 - 160,385,626 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1135,865,679 - 135,888,971 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Flna
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1560614
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.