Flna (filamin A) - Rat Genome Database
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Gene: Flna (filamin A) Rattus norvegicus
Analyze
Symbol: Flna
Name: filamin A
RGD ID: 1560614
Description: Exhibits SMAD binding activity and mu-type opioid receptor binding activity. Involved in several processes, including animal organ development; mRNA transcription by RNA polymerase II; and protein localization to bicellular tight junction. Localizes to several cellular components, including cytoskeleton; dendrite; and glutamatergic synapse. Used to study periventricular nodular heterotopia. Human ortholog(s) of this gene implicated in X-linked recessive disease (multiple); bone development disease (multiple); heart valve disease (multiple); periventricular nodular heterotopia; and terminal osseous dysplasia. Orthologous to human FLNA (filamin A); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; integrin mediated signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: actin binding protein 280; Endothelial actin-binding protein 280); filamin A, alpha; filamin, alpha; filamin-A; LOC293860; RGD1560614; similar to Filamin A (Alpha-filamin) (Filamin 1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin); similar to Filamin A (Alpha-filamin, Endothelial actin-binding protein 280)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X152,007,758 - 152,034,266 (-)NCBI
Rnor_6.0 EnsemblX156,463,953 - 156,487,245 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X156,460,785 - 156,487,245 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01152,200,936 - 152,227,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,362,334 - 160,385,626 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1135,865,679 - 135,888,971 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenoleukodystrophy  (ISO)
Aneurysm  (ISO)
aortic aneurysm  (ISO)
Arterial Thrombosis  (ISO)
arterial tortuosity syndrome  (ISO)
autistic disorder  (ISO)
Breast Neoplasms  (ISO)
colitis  (ISO)
connective tissue disease  (ISO)
craniosynostosis  (ISO)
Dwarfism  (ISO)
Ehlers-Danlos syndrome  (ISO)
Ehlers-Danlos syndrome classic type 1  (ISO)
epilepsy  (ISO)
Experimental Liver Cirrhosis  (ISO)
Familial Thoracic Aortic Aneurysm 2  (ISO)
FG syndrome  (ISO)
FG Syndrome 2  (ISO)
frontometaphyseal dysplasia  (ISO)
frontometaphyseal dysplasia 1  (ISO)
genetic disease  (ISO)
hemorrhagic disease  (ISO)
hydronephrosis  (ISO)
intellectual disability  (ISO)
Juberg Hayward Syndrome  (ISO)
Malformations of Cortical Development, Group II  (ISO)
Marfan syndrome  (ISO)
Melnick-Needles syndrome  (ISO)
microcephaly  (ISO)
mitral valve prolapse  (ISO)
osteochondrodysplasia  (ISO)
otopalatodigital syndrome spectrum disorder  (ISO)
otopalatodigital syndrome type 1  (ISO)
otopalatodigital syndrome type 2  (ISO)
periventricular nodular heterotopia  (IMP,ISO)
Periventricular Nodular Heterotopia 4  (ISO)
Phyllodes Tumor  (ISO)
prune belly syndrome  (ISO)
scoliosis  (ISO)
severe congenital encephalopathy due to MECP2 mutation  (ISO)
terminal osseous dysplasia  (ISO)
thrombocytopenia  (ISO)
tuberous sclerosis  (ISO)
visual epilepsy  (ISO)
Wolff-Parkinson-White syndrome  (ISO)
X-linked cardiac valvular dysplasia  (ISO)
X-linked chronic idiopathic intestinal pseudo-obstruction  (ISO)
X-linked Emery-Dreifuss muscular dystrophy 1  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
artesunate  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dihydroartemisinin  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
genistein  (ISO)
glafenine  (EXP)
glyphosate  (ISO)
graphite  (ISO)
hydrogen peroxide  (ISO)
isotretinoin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
levofloxacin  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel sulfate  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
pentanal  (ISO)
phenethyl isothiocyanate  (EXP)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
tebuconazole  (ISO)
tetrachloromethane  (ISO)
toluene  (ISO)
tributylstannane  (ISO)
triphenylstannane  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
wortmannin  (ISO)
xylitol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin crosslink formation  (ISO)
actin cytoskeleton organization  (ISO)
actin cytoskeleton reorganization  (ISO)
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (ISO)
angiogenesis  (ISO)
blood vessel remodeling  (ISO)
cell-cell junction organization  (ISO)
cerebral cortex development  (IEP)
cilium assembly  (ISO)
cytoplasmic sequestering of protein  (ISO)
early endosome to late endosome transport  (ISO)
epithelial to mesenchymal transition  (ISO)
establishment of protein localization  (ISO)
establishment of Sertoli cell barrier  (IMP)
formation of radial glial scaffolds  (IMP)
heart morphogenesis  (ISO)
mitotic spindle assembly  (ISO)
mRNA transcription by RNA polymerase II  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by RNA polymerase I  (ISO)
platelet aggregation  (ISO)
positive regulation of actin filament bundle assembly  (IMP)
positive regulation of axon regeneration  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of integrin-mediated signaling pathway  (ISO)
positive regulation of neural precursor cell proliferation  (IMP)
positive regulation of neuron migration  (IMP)
positive regulation of potassium ion transmembrane transport  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
protein localization to bicellular tight junction  (IMP)
protein localization to cell surface  (ISO)
protein localization to plasma membrane  (ISO)
protein stabilization  (ISO)
receptor clustering  (ISO)
regulation of actin filament bundle assembly  (ISO)
regulation of cell migration  (ISO)
regulation of membrane repolarization during cardiac muscle cell action potential  (ISO)
semaphorin-plexin signaling pathway  (ISO)
synapse organization  (ISO)
tubulin deacetylation  (ISO)
wound healing, spreading of cells  (ISO)

Cellular Component

References

References - curated
1. Aalberts JJ, etal., Am J Med Genet A. 2014 Jan;164A(1):113-9. doi: 10.1002/ajmg.a.36211. Epub 2013 Nov 15.
2. Abrass CK and Hansen KM, J Biol Chem. 2010 Apr 23;285(17):12925-34. doi: 10.1074/jbc.M109.061754. Epub 2010 Feb 18.
3. Bouvard D, etal., Nat Rev Mol Cell Biol. 2013 Jul;14(7):430-42. doi: 10.1038/nrm3599. Epub 2013 May 30.
4. Carabalona A, etal., Hum Mol Genet. 2012 Mar 1;21(5):1004-17. doi: 10.1093/hmg/ddr531. Epub 2011 Nov 10.
5. Fennell N, etal., Eur J Hum Genet. 2015 Dec;23(12):1684-8. doi: 10.1038/ejhg.2015.31. Epub 2015 Apr 15.
6. Fox JW, etal., Neuron. 1998 Dec;21(6):1315-25.
7. Hazrati LN, etal., J Neuropathol Exp Neurol. 2008 Jul;67(7):669-76. doi: 10.1097/NEN.0b013e31817d7a06.
8. Kyndt F, etal., Circulation. 2007 Jan 2;115(1):40-9. Epub 2006 Dec 26.
9. Lesourne R, etal., J Immunol. 2005 Feb 1;174(3):1365-73.
10. Nakamura F, etal., Nat Commun. 2014 Oct 31;5:5325. doi: 10.1038/ncomms6325.
11. Noam Y, etal., J Comp Neurol. 2012 Sep 1;520(13):3013-34. doi: 10.1002/cne.23106.
12. Oegema R, etal., Am J Med Genet A. 2013 Sep;161A(9):2376-84. doi: 10.1002/ajmg.a.36109. Epub 2013 Jul 19.
13. OMIM Disease Annotation Pipeline
14. Parrini E, etal., J Med Genet. 2015 Jun;52(6):405-12. doi: 10.1136/jmedgenet-2014-102959. Epub 2015 Mar 9.
15. Pi M, etal., Endocrinology. 2002 Oct;143(10):3830-8.
16. Pipeline to import KEGG annotations from KEGG into RGD
17. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. Ramakrishnan NA, etal., J Biol Chem. 2012 Nov 2;287(45):37628-46. doi: 10.1074/jbc.M112.375832. Epub 2012 Sep 4.
19. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. RGD automated import pipeline for gene-chemical interactions
21. RGD comprehensive gene curation
22. Robertson SP, etal., Am J Med Genet A. 2006 Aug 15;140(16):1726-36.
23. Robertson SP, etal., Nat Genet. 2003 Apr;33(4):487-91. Epub 2003 Mar 3.
24. Segura I, etal., Cell Rep. 2016 Mar 22;14(11):2653-67. doi: 10.1016/j.celrep.2016.02.047. Epub 2016 Mar 10.
25. Sheen VL, etal., Hum Mol Genet. 2001 Aug 15;10(17):1775-83.
26. Stefanova M, etal., Am J Med Genet A. 2005 Feb 1;132A(4):386-90.
27. Su W, etal., Endocrinology. 2012 Oct;153(10):5023-35. Epub 2012 Aug 7.
28. Torrado M, etal., Invest Ophthalmol Vis Sci 2004 Nov;45(11):3955-63.
29. Wang HY and Burns LH, PLoS One. 2009;4(1):e4282. doi: 10.1371/journal.pone.0004282. Epub 2009 Jan 27.
30. Zhang L, etal., Neuron. 2014 Oct 1;84(1):78-91. doi: 10.1016/j.neuron.2014.09.009.
Additional References at PubMed
PMID:1833070   PMID:2391361   PMID:3138234   PMID:4044584   PMID:9412467   PMID:10051605   PMID:10692483   PMID:11909861   PMID:12704190   PMID:12761501   PMID:15509752   PMID:15632090  
PMID:15684392   PMID:16291724   PMID:17172441   PMID:17536008   PMID:18177638   PMID:18253501   PMID:18322202   PMID:18548008   PMID:18555800   PMID:19056867   PMID:19946888   PMID:20458337  
PMID:20713593   PMID:21362503   PMID:21423176   PMID:21478251   PMID:21507248   PMID:21709252   PMID:21914078   PMID:22114352   PMID:22121117   PMID:22307607   PMID:22658674   PMID:22681889  
PMID:23106098   PMID:23376485   PMID:23382103   PMID:23533145   PMID:23979707   PMID:24403084   PMID:24436304   PMID:24828612   PMID:24951510   PMID:25468996   PMID:26157139   PMID:26460884  


Genomics

Comparative Map Data
Flna
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X152,007,758 - 152,034,266 (-)NCBI
Rnor_6.0 EnsemblX156,463,953 - 156,487,245 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X156,460,785 - 156,487,245 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01152,200,936 - 152,227,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,362,334 - 160,385,626 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1135,865,679 - 135,888,971 (+)NCBICelera
Cytogenetic MapXq37NCBI
FLNA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX154,348,524 - 154,374,634 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 EnsemblX154,348,524 - 154,374,638 (-)EnsemblGRCh38hg38GRCh38
GRCh38X154,348,531 - 154,374,634 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,576,899 - 153,603,002 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,230,091 - 153,252,845 (-)NCBINCBI36hg18NCBI36
Build 34X153,097,811 - 153,123,776NCBI
CeleraX153,737,962 - 153,764,068 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX142,154,186 - 142,180,218 (-)NCBIHuRef
CHM1_1X153,488,516 - 153,514,622 (-)NCBICHM1_1
Flna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,267,067 - 73,293,787 (-)NCBIGRCm39mm39
GRCm39 EnsemblX73,267,067 - 73,293,426 (-)Ensembl
GRCm38X74,223,461 - 74,249,854 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,223,461 - 74,249,820 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,468,800 - 71,491,873 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X71,468,800 - 71,491,873 (-)NCBImm8
CeleraX65,477,570 - 65,500,684 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.89NCBI
Flna
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580874,233 - 895,232 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955580874,233 - 895,172 (+)NCBIChiLan1.0ChiLan1.0
FLNA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v0X143,799,088 - 143,825,282 (+)NCBIMhudiblu_PPA_v0panPan3
FLNA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX122,061,455 - 122,083,203 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X122,058,303 - 122,083,467 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Flna
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049368091,097,288 - 1,123,206 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLNA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,890,142 - 124,917,171 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,889,934 - 124,915,000 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FLNA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,657,580 - 128,683,812 (-)NCBI
ChlSab1.1 EnsemblX128,657,393 - 128,680,531 (-)Ensembl
Flna
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624946812,278 - 836,307 (+)NCBI

Position Markers
RH134438  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X156,487,025 - 156,487,209NCBIRnor6.0
Rnor_5.01152,227,171 - 152,227,355UniSTSRnor5.0
RGSC_v3.4X160,385,406 - 160,385,590UniSTSRGSC3.4
Celera1135,888,751 - 135,888,935UniSTS
Cytogenetic MapXq37UniSTS
REN89263  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X156,484,142 - 156,484,381NCBIRnor6.0
Rnor_5.01152,224,288 - 152,224,527UniSTSRnor5.0
RGSC_v3.4X160,382,523 - 160,382,762UniSTSRGSC3.4
Celera1135,885,868 - 135,886,107UniSTS
Cytogenetic MapXq37UniSTS
REN89262  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X156,484,361 - 156,484,613NCBIRnor6.0
Rnor_5.01152,224,507 - 152,224,759UniSTSRnor5.0
RGSC_v3.4X160,382,742 - 160,382,994UniSTSRGSC3.4
Celera1135,886,087 - 135,886,339UniSTS
Cytogenetic MapXq37UniSTS
REN89288  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X156,477,991 - 156,478,281NCBIRnor6.0
Rnor_5.01152,218,137 - 152,218,427UniSTSRnor5.0
RGSC_v3.4X160,376,372 - 160,376,662UniSTSRGSC3.4
Celera1135,879,717 - 135,880,007UniSTS
Cytogenetic MapXq37UniSTS
REN89289  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X156,477,784 - 156,478,011NCBIRnor6.0
Rnor_5.01152,217,930 - 152,218,157UniSTSRnor5.0
RGSC_v3.4X160,376,165 - 160,376,392UniSTSRGSC3.4
Celera1135,879,510 - 135,879,737UniSTS
Cytogenetic MapXq37UniSTS
REN89318  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X156,471,293 - 156,471,545NCBIRnor6.0
Rnor_5.01152,211,439 - 152,211,691UniSTSRnor5.0
RGSC_v3.4X160,369,674 - 160,369,926UniSTSRGSC3.4
Celera1135,873,019 - 135,873,271UniSTS
Cytogenetic MapXq37UniSTS
REN89349  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X156,464,109 - 156,464,336NCBIRnor6.0
Rnor_5.01152,204,255 - 152,204,482UniSTSRnor5.0
RGSC_v3.4X160,362,490 - 160,362,717UniSTSRGSC3.4
Celera1135,865,835 - 135,866,062UniSTS
Cytogenetic MapXq37UniSTS
ECD00293  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X156,467,713 - 156,468,778NCBIRnor6.0
Rnor_5.01152,207,859 - 152,208,924UniSTSRnor5.0
RGSC_v3.4X160,366,094 - 160,367,159UniSTSRGSC3.4
Celera1135,869,439 - 135,870,504UniSTS
Cytogenetic MapXq37UniSTS
ECD01291  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X156,469,813 - 156,470,649NCBIRnor6.0
Rnor_5.01152,209,959 - 152,210,795UniSTSRnor5.0
RGSC_v3.4X160,368,194 - 160,369,030UniSTSRGSC3.4
Celera1135,871,539 - 135,872,375UniSTS
Cytogenetic MapXq37UniSTS
ECD02527  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X156,480,784 - 156,481,944NCBIRnor6.0
Rnor_5.01152,220,930 - 152,222,090UniSTSRnor5.0
RGSC_v3.4X160,379,165 - 160,380,325UniSTSRGSC3.4
Celera1135,882,510 - 135,883,670UniSTS
Cytogenetic MapXq37UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X44320616158345622Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118715462159970021Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X134627816159970021Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:52
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000068489
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3
Medium 3 43 50 34 19 34 8 11 74 35 37 11 8
Low 7 7 7 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000079889   ⟹   ENSRNOP00000070703
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX156,463,953 - 156,487,245 (+)Ensembl
RefSeq Acc Id: NM_001134599   ⟹   NP_001128071
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X152,007,758 - 152,031,052 (-)NCBI
Rnor_6.0X156,463,953 - 156,487,245 (+)NCBI
Rnor_5.01152,200,936 - 152,227,391 (+)NCBI
RGSC_v3.4X160,362,334 - 160,385,626 (+)RGD
Celera1135,865,679 - 135,888,971 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229569   ⟹   XP_006229631
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X152,007,769 - 152,034,266 (-)NCBI
Rnor_6.0X156,460,785 - 156,487,240 (+)NCBI
Rnor_5.01152,200,936 - 152,227,391 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229570   ⟹   XP_006229632
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X152,007,769 - 152,034,266 (-)NCBI
Rnor_6.0X156,460,785 - 156,487,240 (+)NCBI
Rnor_5.01152,200,936 - 152,227,391 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099535   ⟹   XP_038955463
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X152,007,769 - 152,031,003 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001128071   ⟸   NM_001134599
- UniProtKB: C0JPT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229631   ⟸   XM_006229569
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006229632   ⟸   XM_006229570
- Peptide Label: isoform X2
- UniProtKB: C0JPT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070703   ⟸   ENSRNOT00000079889
RefSeq Acc Id: XP_038955463   ⟸   XM_039099535
- Peptide Label: isoform X1
Protein Domains
Calponin-homology (CH)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702049
Promoter ID:EPDNEW_R12573
Type:multiple initiation site
Name:Flna_1
Description:filamin A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X156,464,013 - 156,464,073EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 152222597 152222598 A G snv LEC/Tj (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560614 AgrOrtholog
Ensembl Genes ENSRNOG00000054890 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070703 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079889 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  Calponin-like_dom_sf UniProtKB/TrEMBL
  Calponin_act-bd UniProtKB/TrEMBL
  Filamin UniProtKB/TrEMBL
  Filamin/ABP280_repeat-like UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
KEGG Report rno:293860 UniProtKB/TrEMBL
NCBI Gene 293860 ENTREZGENE
Pfam Filamin UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
PharmGKB FLNA RGD
PhenoGen Flna PhenoGen
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  FILAMIN_REPEAT UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
SMART IG_FLMN UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
Superfamily-SCOP Calponin-homology UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
UniProt C0JPT7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-11 Flna  filamin A  Flna  filamin A, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-24 Flna  filamin A, alpha  Flna  filamin, alpha   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Flna  filamin, alpha   Flna_predicted  filamin, alpha (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Flna_predicted  filamin, alpha (predicted)  RGD1560614_predicted  similar to Filamin A (Alpha-filamin; Endothelial actin-binding protein 280) (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-10 RGD1560614_predicted  similar to Filamin A (Alpha-filamin; Endothelial actin-binding protein 280) (predicted)    similar to Filamin A (Alpha-filamin) (Filamin 1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1560614_predicted  similar to Filamin A (Alpha-filamin) (Filamin 1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin) (predicted)  LOC293860  similar to Filamin A (Alpha-filamin) (Filamin 1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC293860  similar to Filamin A (Alpha-filamin) (Filamin 1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin)      Symbol and Name status set to provisional 70820 PROVISIONAL