SMAD4 (SMAD family member 4) - Rat Genome Database

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Gene: SMAD4 (SMAD family member 4) Canis lupus familiaris
Analyze
Symbol: SMAD4
Name: SMAD family member 4
RGD ID: 12260602
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); filamin binding (ortholog); INVOLVED IN adrenal gland development (ortholog); anatomical structure morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN altered transforming growth factor-beta Smad dependent signaling pathway; Bone morphogenetic proteins signaling pathway; colorectal cancer pathway; ASSOCIATED WITH Acro-Osteolysis (ortholog); aortic disease (ortholog); brachydactyly (ortholog); FOUND IN heteromeric SMAD protein complex (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MADH4; mothers against decapentaplegic homolog 4; mothers against decapentaplegic-like 4; SMAD, mothers against DPP homolog 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,875,989 - 23,930,027 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,882,139 - 23,969,405 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha124,868,005 - 24,956,178 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,767,402 - 23,821,366 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,772,519 - 23,821,180 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1123,833,038 - 23,921,205 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,719,264 - 23,807,404 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,987,158 - 24,041,139 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acro-Osteolysis  (ISO)
aortic disease  (ISO)
brachydactyly  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
cervical cancer  (ISO)
cholangiocarcinoma  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cicatrix  (ISO)
cognitive disorder  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal adenoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Craniofacial Abnormalities  (ISO)
Cronkhite-Canada syndrome  (ISO)
Deafness  (ISO)
endometrial carcinoma  (ISO)
esophageal carcinoma  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Colitis  (ISO)
Experimental Liver Cirrhosis  (ISO)
gallbladder cancer  (ISO)
Gallstones  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal system cancer  (ISO)
genetic disease  (ISO)
Growth Mental Deficiency Syndrome of Myhre  (ISO)
head and neck squamous cell carcinoma  (ISO)
hemorrhagic disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
hereditary hemorrhagic telangiectasia  (ISO)
Hereditary Hemorrhagic Telangiectasia, Type 1  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Heterotopic Ossification  (ISO)
Human Viral Hepatitis  (ISO)
Hypoglossal Nerve Injuries  (ISO)
intellectual disability  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
invasive ductal carcinoma  (ISO)
juvenile polyposis syndrome  (ISO)
juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome  (ISO)
Liver Metastasis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lymphatic Metastasis  (ISO)
Lynch syndrome  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
Microphthalmia, Cataracts, and Iris Abnormalities  (ISO)
muscular disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
Odontogenic Cysts  (ISO)
osteogenesis imperfecta  (ISO)
ovarian cancer  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
Parasitic Liver Diseases  (ISO)
pre-malignant neoplasm  (ISO)
Primary Pulmonary Hypertension, 1  (ISO)
prostate adenocarcinoma  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
seminoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
thoracic aortic aneurysm  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
anatomical structure morphogenesis  (IEA,ISO)
anterior/posterior pattern specification  (IEA,ISO)
atrioventricular canal development  (IEA)
atrioventricular valve formation  (IEA)
axon guidance  (IEA,ISO)
BMP signaling pathway  (IEA)
brainstem development  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac septum development  (IEA)
cell differentiation  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cellular response to glucose stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (IEA)
developmental growth  (IEA,ISO)
DNA-templated transcription  (IEA)
embryonic digit morphogenesis  (IEA)
endocardial cell differentiation  (IEA)
endoderm development  (IEA,ISO)
endothelial cell activation  (IEA)
epithelial cell migration  (IEA)
epithelial to mesenchymal transition  (IEA)
epithelial to mesenchymal transition involved in endocardial cushion formation  (IEA)
ERK1 and ERK2 cascade  (ISO)
extrinsic apoptotic signaling pathway  (IEA)
female gonad development  (IEA,ISO)
female gonad morphogenesis  (IEA,ISO)
formation of anatomical boundary  (IEA,ISO)
gastrulation  (IEA,ISO)
gastrulation with mouth forming second  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
interleukin-6-mediated signaling pathway  (IEA)
intracellular iron ion homeostasis  (IEA)
intracellular signal transduction  (IEA)
kidney development  (IEA,ISO)
left ventricular cardiac muscle tissue morphogenesis  (IEA)
male gonad development  (IEA,ISO)
mesendoderm development  (IEA,ISO)
mesoderm development  (IEA,ISO)
metanephric mesenchyme morphogenesis  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cardiac muscle hypertrophy  (IEA)
negative regulation of cardiac myofibril assembly  (IEA)
negative regulation of cell growth  (IEA)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of ERK1 and ERK2 cascade  (IEA)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
nephrogenic mesenchyme morphogenesis  (IEA)
neural crest cell differentiation  (IEA,ISO)
neuron fate commitment  (IEA,ISO)
neuron fate specification  (IEA)
osteoblast differentiation  (ISO)
outflow tract septum morphogenesis  (IEA)
ovarian follicle development  (IEA,ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell proliferation involved in heart valve morphogenesis  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of extracellular matrix assembly  (IEA)
positive regulation of follicle-stimulating hormone secretion  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of luteinizing hormone secretion  (IEA,ISO)
positive regulation of miRNA transcription  (IEA)
positive regulation of SMAD protein signal transduction  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (IEA)
regulation of cell population proliferation  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of hair follicle development  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of transforming growth factor beta receptor signaling pathway  (IEA)
regulation of transforming growth factor beta2 production  (IEA)
response to hypoxia  (IEA)
response to transforming growth factor beta  (IEA)
sebaceous gland development  (IEA,ISO)
secondary palate development  (IEA)
seminiferous tubule development  (IEA,ISO)
single fertilization  (IEA,ISO)
SMAD protein signal transduction  (IEA,ISO)
somite rostral/caudal axis specification  (IEA,ISO)
spermatogenesis  (IEA,ISO)
tissue morphogenesis  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
transforming growth factor beta receptor signaling pathway  (IEA,ISO)
uterus development  (IEA,ISO)
ventricular septum morphogenesis  (IEA)

References
Additional References at PubMed
PMID:21486406   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SMAD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,875,989 - 23,930,027 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,882,139 - 23,969,405 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha124,868,005 - 24,956,178 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,767,402 - 23,821,366 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,772,519 - 23,821,180 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1123,833,038 - 23,921,205 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,719,264 - 23,807,404 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,987,158 - 24,041,139 (-)NCBIUU_Cfam_GSD_1.0
SMAD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381851,030,213 - 51,085,042 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1851,028,528 - 51,085,045 (+)EnsemblGRCh38hg38GRCh38
GRCh371848,556,583 - 48,611,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361846,810,611 - 46,860,145 (+)NCBINCBI36Build 36hg18NCBI36
Build 341846,810,610 - 46,860,144NCBI
Celera1845,413,367 - 45,468,195 (+)NCBICelera
Cytogenetic Map18q21.2NCBI
HuRef1845,411,927 - 45,466,923 (+)NCBIHuRef
CHM1_11848,551,997 - 48,606,836 (+)NCBICHM1_1
T2T-CHM13v2.01851,231,926 - 51,286,759 (+)NCBIT2T-CHM13v2.0
Smad4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391873,767,861 - 73,836,862 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1873,772,080 - 73,836,851 (-)EnsemblGRCm39 Ensembl
GRCm381873,634,790 - 73,703,791 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1873,639,009 - 73,703,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv371873,798,667 - 73,863,395 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361873,764,382 - 73,829,110 (-)NCBIMGSCv36mm8
Celera1874,884,056 - 74,923,073 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1849.51NCBI
Smad4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81869,518,988 - 69,549,684 (-)NCBIGRCr8
mRatBN7.21867,243,742 - 67,274,438 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1867,243,742 - 67,274,438 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1869,351,818 - 69,382,528 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01870,026,538 - 70,057,217 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01867,891,801 - 67,922,479 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01869,626,682 - 69,657,373 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1869,627,757 - 69,671,199 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01868,773,326 - 68,802,354 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41870,432,705 - 70,461,541 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11870,504,785 - 70,534,814 (-)NCBI
Celera1865,246,042 - 65,276,480 (-)NCBICelera
Cytogenetic Map18q12.2NCBI
Smad4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540235,961,165 - 35,994,538 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540235,956,080 - 36,001,746 (+)NCBIChiLan1.0ChiLan1.0
SMAD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21768,549,261 - 68,603,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11854,241,866 - 54,296,559 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01844,402,112 - 44,456,779 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11847,692,311 - 47,802,530 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1847,764,568 - 47,797,359 (+)Ensemblpanpan1.1panPan2
Smad4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494437,008,523 - 37,038,961 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649712,249,140 - 12,278,123 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649712,242,869 - 12,278,012 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1100,589,850 - 100,628,029 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11100,521,843 - 100,633,501 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21110,456,997 - 110,568,659 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11829,894,157 - 29,951,445 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1829,897,621 - 29,934,478 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660504,018,900 - 4,079,370 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477814,570,348 - 14,630,325 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477814,570,025 - 14,629,950 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SMAD4
474 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 16 6 6 6 10 4
Low 1 5 6 6 6 6 6 8 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022416896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022416897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022416898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022416900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022416902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022416903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022416905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038465372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038465373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038465374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038465375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038465376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038487178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038487242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038487377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038487434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038525980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038525981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038525982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038525983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038525984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038590286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038590287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038590288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038590289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038590290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038654107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038654108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038654109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002625111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005319814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005331279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005353474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005388056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY514735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000000266   ⟹   ENSCAFP00000000241
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl123,883,546 - 23,914,318 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000061940   ⟹   ENSCAFP00000053098
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl123,882,139 - 23,969,405 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000082853   ⟹   ENSCAFP00000052646
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl123,882,139 - 23,969,405 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845005687   ⟹   ENSCAFP00845004513
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl123,772,519 - 23,821,180 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845005696   ⟹   ENSCAFP00845004518
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl123,772,544 - 23,821,180 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845005706   ⟹   ENSCAFP00845004525
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl123,774,988 - 23,821,180 (-)Ensembl
RefSeq Acc Id: XM_022416898   ⟹   XP_022272606
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1123,875,989 - 23,914,318 (-)NCBI
Dog10K_Boxer_Tasha124,868,005 - 24,916,852 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038465372   ⟹   XP_038321300
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1123,833,038 - 23,881,884 (-)NCBI
RefSeq Acc Id: XM_038465373   ⟹   XP_038321301
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1123,833,038 - 23,879,823 (-)NCBI
RefSeq Acc Id: XM_038465374   ⟹   XP_038321302
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1123,833,038 - 23,921,205 (-)NCBI
RefSeq Acc Id: XM_038465375   ⟹   XP_038321303
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1123,835,439 - 23,881,884 (-)NCBI
RefSeq Acc Id: XM_038465376   ⟹   XP_038321304
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1123,843,329 - 23,881,884 (-)NCBI
RefSeq Acc Id: XM_038487178   ⟹   XP_038343106
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha124,868,005 - 24,914,790 (-)NCBI
RefSeq Acc Id: XM_038487242   ⟹   XP_038343170
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha124,868,005 - 24,956,178 (-)NCBI
RefSeq Acc Id: XM_038487377   ⟹   XP_038343305
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha124,870,406 - 24,916,852 (-)NCBI
RefSeq Acc Id: XM_038487434   ⟹   XP_038343362
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha124,878,296 - 24,916,852 (-)NCBI
RefSeq Acc Id: XM_038525980   ⟹   XP_038381908
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0123,987,158 - 24,041,139 (-)NCBI
RefSeq Acc Id: XM_038525981   ⟹   XP_038381909
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0123,987,158 - 24,039,082 (-)NCBI
RefSeq Acc Id: XM_038525982   ⟹   XP_038381910
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0123,987,158 - 24,041,139 (-)NCBI
RefSeq Acc Id: XM_038525983   ⟹   XP_038381911
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0123,994,692 - 24,041,139 (-)NCBI
RefSeq Acc Id: XM_038525984   ⟹   XP_038381912
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0124,002,573 - 24,041,139 (-)NCBI
RefSeq Acc Id: XM_038590286   ⟹   XP_038446214
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0123,719,264 - 23,768,119 (-)NCBI
RefSeq Acc Id: XM_038590287   ⟹   XP_038446215
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0123,719,264 - 23,766,043 (-)NCBI
RefSeq Acc Id: XM_038590288   ⟹   XP_038446216
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0123,719,264 - 23,807,404 (-)NCBI
RefSeq Acc Id: XM_038590289   ⟹   XP_038446217
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0123,721,665 - 23,768,119 (-)NCBI
RefSeq Acc Id: XM_038590290   ⟹   XP_038446218
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0123,729,555 - 23,768,119 (-)NCBI
RefSeq Acc Id: XM_038654107   ⟹   XP_038510035
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0123,767,402 - 23,821,366 (-)NCBI
RefSeq Acc Id: XM_038654108   ⟹   XP_038510036
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0123,767,402 - 23,819,312 (-)NCBI
RefSeq Acc Id: XM_038654109   ⟹   XP_038510037
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0123,767,402 - 23,805,657 (-)NCBI
RefSeq Acc Id: XR_005319814
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1123,834,423 - 23,881,884 (-)NCBI
RefSeq Acc Id: XR_005331279
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha124,869,390 - 24,916,852 (-)NCBI
RefSeq Acc Id: XR_005353474
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0123,993,676 - 24,041,139 (-)NCBI
RefSeq Acc Id: XR_005388056
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0123,720,649 - 23,768,119 (-)NCBI
Protein Sequences
Protein RefSeqs XP_022272606 (Get FASTA)   NCBI Sequence Viewer  
  XP_038321300 (Get FASTA)   NCBI Sequence Viewer  
  XP_038321301 (Get FASTA)   NCBI Sequence Viewer  
  XP_038321302 (Get FASTA)   NCBI Sequence Viewer  
  XP_038321303 (Get FASTA)   NCBI Sequence Viewer  
  XP_038321304 (Get FASTA)   NCBI Sequence Viewer  
  XP_038343106 (Get FASTA)   NCBI Sequence Viewer  
  XP_038343170 (Get FASTA)   NCBI Sequence Viewer  
  XP_038343305 (Get FASTA)   NCBI Sequence Viewer  
  XP_038343362 (Get FASTA)   NCBI Sequence Viewer  
  XP_038381908 (Get FASTA)   NCBI Sequence Viewer  
  XP_038381909 (Get FASTA)   NCBI Sequence Viewer  
  XP_038381910 (Get FASTA)   NCBI Sequence Viewer  
  XP_038381911 (Get FASTA)   NCBI Sequence Viewer  
  XP_038381912 (Get FASTA)   NCBI Sequence Viewer  
  XP_038446214 (Get FASTA)   NCBI Sequence Viewer  
  XP_038446215 (Get FASTA)   NCBI Sequence Viewer  
  XP_038446216 (Get FASTA)   NCBI Sequence Viewer  
  XP_038446217 (Get FASTA)   NCBI Sequence Viewer  
  XP_038446218 (Get FASTA)   NCBI Sequence Viewer  
  XP_038510035 (Get FASTA)   NCBI Sequence Viewer  
  XP_038510036 (Get FASTA)   NCBI Sequence Viewer  
  XP_038510037 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT44570 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000000241.4
  ENSCAFP00000052646.2
  ENSCAFP00000053098.1
  ENSCAFP00030006820.1
  ENSCAFP00030006902.1
  ENSCAFP00030006928.1
  ENSCAFP00040019821.1
  ENSCAFP00040019988.1
  ENSCAFP00040019992.1
  ENSCAFP00845004513
  ENSCAFP00845004513.1
  ENSCAFP00845004518.1
  ENSCAFP00845004525.1
RefSeq Acc Id: XP_022272606   ⟸   XM_022416898
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SDJ3 (UniProtKB/TrEMBL),   A0A8C0LBT9 (UniProtKB/TrEMBL),   A0A8I3RR80 (UniProtKB/TrEMBL),   A0A8P0T534 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000241   ⟸   ENSCAFT00000000266
RefSeq Acc Id: ENSCAFP00000052646   ⟸   ENSCAFT00000082853
RefSeq Acc Id: ENSCAFP00000053098   ⟸   ENSCAFT00000061940
RefSeq Acc Id: XP_038321302   ⟸   XM_038465374
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038321300   ⟸   XM_038465372
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038321301   ⟸   XM_038465373
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038321303   ⟸   XM_038465375
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038321304   ⟸   XM_038465376
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038446216   ⟸   XM_038590288
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038446214   ⟸   XM_038590286
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038446215   ⟸   XM_038590287
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038446217   ⟸   XM_038590289
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038446218   ⟸   XM_038590290
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038510035   ⟸   XM_038654107
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RR80 (UniProtKB/TrEMBL),   A0A8P0T534 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038510036   ⟸   XM_038654108
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RR80 (UniProtKB/TrEMBL),   A0A8P0T534 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038510037   ⟸   XM_038654109
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SDJ3 (UniProtKB/TrEMBL),   A0A8C0LBT9 (UniProtKB/TrEMBL),   A0A8I3RR80 (UniProtKB/TrEMBL),   A0A8P0T534 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038343170   ⟸   XM_038487242
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SDJ3 (UniProtKB/TrEMBL),   A0A8C0LBT9 (UniProtKB/TrEMBL),   A0A8I3RR80 (UniProtKB/TrEMBL),   A0A8P0T534 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038343106   ⟸   XM_038487178
- Peptide Label: isoform X2
- UniProtKB: A0A8C0SDJ3 (UniProtKB/TrEMBL),   A0A8C0LBT9 (UniProtKB/TrEMBL),   A0A8I3RR80 (UniProtKB/TrEMBL),   A0A8P0T534 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038343305   ⟸   XM_038487377
- Peptide Label: isoform X9
- UniProtKB: A0A8I3RR80 (UniProtKB/TrEMBL),   A0A8P0T534 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038343362   ⟸   XM_038487434
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038381910   ⟸   XM_038525982
- Peptide Label: isoform X2
- UniProtKB: A0A8C0LBT9 (UniProtKB/TrEMBL),   A0A8C0SDJ3 (UniProtKB/TrEMBL),   A0A8I3RR80 (UniProtKB/TrEMBL),   A0A8P0T534 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038381908   ⟸   XM_038525980
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RR80 (UniProtKB/TrEMBL),   A0A8P0T534 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038381909   ⟸   XM_038525981
- Peptide Label: isoform X1
- UniProtKB: A0A8I3RR80 (UniProtKB/TrEMBL),   A0A8P0T534 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038381911   ⟸   XM_038525983
- Peptide Label: isoform X7
- UniProtKB: A0A8I3RR80 (UniProtKB/TrEMBL),   A0A8P0T534 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038381912   ⟸   XM_038525984
- Peptide Label: isoform X8
RefSeq Acc Id: ENSCAFP00845004518   ⟸   ENSCAFT00845005696
RefSeq Acc Id: ENSCAFP00845004513   ⟸   ENSCAFT00845005687
RefSeq Acc Id: ENSCAFP00845004525   ⟸   ENSCAFT00845005706
Protein Domains
MH1   MH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000164 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004094 UniProtKB/TrEMBL
  ENSCAFG00040012385 UniProtKB/TrEMBL
  ENSCAFG00845003229 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000266.5 UniProtKB/TrEMBL
  ENSCAFT00000061940.2 UniProtKB/TrEMBL
  ENSCAFT00000082853.2 UniProtKB/TrEMBL
  ENSCAFT00030007774.1 UniProtKB/TrEMBL
  ENSCAFT00030007867.1 UniProtKB/TrEMBL
  ENSCAFT00030007898.1 UniProtKB/TrEMBL
  ENSCAFT00040022875.1 UniProtKB/TrEMBL
  ENSCAFT00040023060.1 UniProtKB/TrEMBL
  ENSCAFT00040023066.1 UniProtKB/TrEMBL
  ENSCAFT00845005687 ENTREZGENE
  ENSCAFT00845005687.1 UniProtKB/TrEMBL
  ENSCAFT00845005696.1 UniProtKB/TrEMBL
  ENSCAFT00845005706.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.10 UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/TrEMBL
NCBI Gene SMAD4 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG UniProtKB/TrEMBL
  MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4 UniProtKB/TrEMBL
  PTHR13703 UniProtKB/TrEMBL
Pfam MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
PROSITE MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
SMART DWA UniProtKB/TrEMBL
  DWB UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/TrEMBL
  SSF56366 UniProtKB/TrEMBL
UniProt A0A8C0LBT9 ENTREZGENE
  A0A8C0MGZ7_CANLF UniProtKB/TrEMBL
  A0A8C0SDJ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SEM5_CANLF UniProtKB/TrEMBL
  A0A8I3MN58_CANLF UniProtKB/TrEMBL
  A0A8I3RR80 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RR81_CANLF UniProtKB/TrEMBL
  A0A8P0T534 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46521 ENTREZGENE